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salivary neoplasm

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https://www.readbyqxmd.com/read/29290822/mir-31-5p-acox1-axis-enhances-tumorigenic-fitness-in-oral-squamous-cell-carcinoma-via-the-promigratory-prostaglandin-e2
#1
Yi-Hsuan Lai, Hsuan Liu, Wei-Fan Chiang, Ting-Wen Chen, Lichieh Julie Chu, Jau-Song Yu, Shu-Jen Chen, Hua-Chien Chen, Bertrand Chin-Ming Tan
During neoplastic development, a multitude of changes in genome-encoded information are progressively selected to confer growth and survival advantages to tumor cells. microRNAs-mRNAs regulatory networks, given their role as a critical layer of robust gene expression control, are frequently altered in neoplasm. However, whether and how these gene perturbations impact metabolic homeostasis remains largely unresolved. Methods: Through targeted miRNA expression screening, we uncovered an oral squamous cell carcinoma (OSCC)-associated miRNAome, among which miR-31-5p was identified based on extent of up-regulation, functional impact on OSCC cell migration and invasion, and direct regulation of the rate-limiting enzyme in peroxisomal β-oxidation, ACOX1...
2018: Theranostics
https://www.readbyqxmd.com/read/29284907/pleomorphic-adenoma-of-minor-salivary-glands-in-child
#2
Jehona Reçica Ahmedi, Enis Ahmedi, Ferjall Perjuci, Resmije Ademi, Ali Gashi, Zana Agani, Fisnik Kurshumliu, Bylbyl Reçica
Introduction: Tumors of salivary glands are very rare in children overall, and rarely in minor salivary glands. Among them pleoomorphic adenoma (PA) is the most common benign tumor of salivary glands in children and it acounts 60% of all salivary neoplasms, frequently found in major salivary glands (85 %) and rarely in minor salivary glands (10-15%). PA appears as painless oval mass, elastic consistency and smooth surface. It characterized by slow evolution of growing. The diagnosis can be confirmed only by histopathological features, after total excision of the lesion...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29274041/intraoral-pigmented-low-grade-adenocarcinoma-not-otherwise-specified-case-report-and-immunohistochemical-study
#3
Jessica Luana Dos Santos, Albina Messias de Almeida Milani Altemani, Alexandre Elias Trivellato, Cássio Edvard Sverzut, Luciana Yamamoto Almeida, Lucas Ribeiro Teixeira, Alfredo Ribeiro-Silva, Jorge Esquiche León
Salivary adenocarcinoma, not otherwise specified (AdCaNOS) is a rare malignant tumor with potential diagnostic challenge, which mainly affects the parotid glands; however, the minor salivary glands can also be involved by AdCaNOS. This paper reports a case of a 45-year-old Afro-descendant woman complaining of a slow-growing mass with 6 months of evolution in the left superior vestibular fornix. Microscopic examination revealed an infiltrative epithelial neoplasm composed of predominantly solid growth pattern, arranged in a lobular configuration, admixed with glandular or ductal structures...
December 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29251639/mammary-analog-secretory-carcinoma-with-etv6-rearrangement-arising-in-the-conjunctiva-and-eyelid
#4
Yongyang Bao, Jiang Li, Yanbo Zhu
Mammary analog secretory carcinoma (MASC) of salivary gland is a recently described neoplasm that morphologically and immunohistochemically resembles secretory carcinoma of the breast. Genetically, both of them harbor ETV-6-NTRK-3 fusion rearrangement. One case of primary MASCs arising from the eyelid is reported. The patient was a 52-year-old man. Microscopically, the tumor exhibited nodular aggregation of solid, tubular, and microcystic/macrocystic structures. Characteristic "colloid-like" eosinophilic secretory material was present within intraluminal spaces...
November 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29238382/a-case-of-central-mucoepidermoid-carcinoma-associated-with-dentigerous-cyst
#5
Sayed Mohammad Razavi, Roya Yahyaabadi, Saeedeh Khalesi
Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland neoplasm. Central MEC (CMEC) is a rare primary intraosseous bony lesion with an incidence of 2%-4.3% of all MECs reported. In this article, we present a rare case of a CMEC in the anterior region of maxilla at a 43-year-old female patient that was arising from a dentigerous cyst. CMECs are extremely rare tumor. They are usually low-grade lesions with favorable prognosis. Odontogenic cysts are one of the origins of this lesion. Treatment of impacted tooth is necessary in the early stage for prevention of this neoplasm...
November 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29237344/epithelial-myoepithelial-carcinoma-of-the-nasal-cavity-clinical-histopathological-and-immunohistochemical-distinction-of-a-case-report
#6
Sally Nguyen, Marjorie Perron, Sylvie Nadeau, Alexandre Nakao Odashiro, Marie-Noëlle Corriveau
BACKGROUND: Epithelial myoepithelial carcinomas (EMCs) are rare low-grade salivary gland tumors. Here, we report the case of a 75-year-old man presenting with an oncocytic variant of EMC of the nasal cavity, initially diagnosed as an oncocytoma. METHODS: Our patient underwent functional sinus surgery in 2012. On pathology, an oncocytic neoplasm was found in the right nasal cavity, characterized by fragments of uniform bland oncocytic cells with bilayered arrangement of nuclei...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29224720/ctnnb1-mutations-in-basal-cell-adenoma-of-the-salivary-gland
#7
Yi-Hsuan Lee, Wen-Chih Huang, Min-Shu Hsieh
BACKGROUND/PURPOSE: Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) are uncommon salivary gland tumors comprising proliferation of basaloid cells. Nuclear β-catenin expression and mutations in its encoding gene (CTNNB1) are reported to be specific to BCA. PIK3CA mutations are only found in BCAC not in BCA. However, in previous studies the number of cases was relatively small. The present study analyzed 44 cases of basal cell neoplasms to identify the CTNNB1 and PIK3CA mutation profiles in this rare salivary gland tumor...
December 7, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29217083/hyalinizing-clear-cell-carcinoma-of-salivary-gland-origin-in-the-head-and-neck-clinical-and-histopathological-analysis
#8
X-H Yang, L Liu, Y-Y Shi, Y-J Hu, Q-G Hu, P Zhang
Hyalinizing clear cell carcinoma (HCCC) is an extremely rare neoplasm of salivary gland origin with a low-grade indolent nature. It is difficult to distinguish from other malignant salivary gland tumours. Clinical outcomes following surgery are generally reported as good. The aim of this study was to further determine the features of HCCC. This study was approved by Medical ethics review of affiliated hospital of jiangsu university. Fourteen new cases of HCCC are reported. The clinical and histopathological data of these 14 cases were analysed alongside those of 141 cases identified in a systematic review of the literature (up to 2016)...
December 4, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29200960/solitary-fibrous-tumor-occurring-in-the-parotid-gland-a-case-report
#9
Meryem Rais, Amine Kessab, Zahra Sayad, Sanae El Mourabit, Redallah Zrarqi, Salma Benazzou, Malik Boulaadas, Nadia Cherradi
Background: Solitary fibrous tumor is an uncommon spindle cell neoplasm of unknown origin. It has been reported in many anatomic sites, with a rare occurrence in the head and neck region. Solitary fibrous tumors of the parotid gland are exceptional; their clinical and radiologic features are non specific, often mimicking more common salivary gland tumors. Pathologic examination and immunohistochemistry are required to make the correct diagnosis. The prognosis is favorable, with most tumors being benign, and complete surgical resection is the treatment of choice...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29193882/giant-cell-tumor-of-temporomandibular-joint-presenting-as-a-parotid-tumor-challenges-in-the-accurate-subclassification-of-giant-cell-tumors-in-an-unusual-location
#10
Rongqin Ren, Sandra Mueller, Adele O Kraft, Celeste N Powers
Fine needle aspiration is frequently used as the initial diagnostic procedure in the work-up of head and neck lesions, including soft tissue masses and salivary gland neoplasms. Giant cell tumors (GCTs), both osseous and extraosseous, are benign tumors that occur, albeit rarely, in the head and neck region. Extraosseous GCTs may be further classified based on their tissue of origin and specific anatomic location. Regardless of location, giant cell tumors are morphologically similar and share cytologic and histologic diagnostic criteria...
November 30, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29184122/bacterial-alterations-in-salivary-microbiota-and-their-association-in-oral-cancer
#11
Wei-Hsiang Lee, Hui-Mei Chen, Shun-Fa Yang, Chao Liang, Chih-Yu Peng, Feng-Mao Lin, Lo-Lin Tsai, Buor-Chang Wu, Chung-Han Hsin, Chun-Yi Chuang, Ting Yang, Tzu-Ling Yang, Shinn-Ying Ho, Wen-Liang Chen, Kwo-Chang Ueng, Hsien-Da Huang, Chien-Ning Huang, Yuh-Jyh Jong
Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity and the fourth leading malignancy and cause of cancer-related death in the male population of Taiwan. Most cases are detected at advanced stages, resulting in poor prognosis. Therefore, improved detection of early oral health disorders is indispensable. The involvement of oral bacteria in inflammation and their association with OSCC progression provide a feasible target for diagnosis. Due to the nature of oral neoplasms, the diagnosis of epithelial precursor lesions is relatively easy compared with that of other types of cancer...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29178364/fine-needle-aspiration-cytology-for-parotid-lesions-can-we-avoid-surgery
#12
Yotam Shkedy, Uri Alkan, Aviram Mizrahi, Tzippy Shochat, Orr Dimitstein, Sara Morgenstern, Thomas Shpitzer, Gideon Bachar
OBJECTIVE: Salivary gland neoplasms are rare tumors, with most arising in the parotid gland. Fine-needle aspiration cytology (FNAC) is a common method for pre-operative evaluation of parotid masses, although its usefulness is controversial. This study was designed to evaluate the accuracy of FNAC in a large cohort of patients, with emphasis on diagnosis of benign tumors and especially Warthin tumor which can be managed conservatively. STUDY DESIGN: Retrospective case series with chart review...
November 27, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29174934/primary-lesions-that-may-imitate-metastatic-tumors-histologically-a-selective-review
#13
REVIEW
Mark R Wick
Several primary pathologic entities in diverse anatomic locations have the potential to simulate metastatic neoplasms histologically. Their misinterpretation as such may result in needless and extensive clinical evaluations that are intended to detect a presumed malignancy at another site. More importantly, mistakes of this type can deprive patients of surgical excisions that could be curative. This presentation considers a review of selected primary lesions that can simulate metastases. They include hemangioblastoma, glioblastoma and meningioma with epithelial metaplasia, choroid plexus carcinomas, primary neuroendocrine carcinomas in unusual locations, special forms of sinonasal and salivary glandular adenocarcinoma, clear-cell thyroid carcinomas, unusual microscopic subtypes of pulmonary adenocarcinoma, epithelioid myomelanocytomas ("sugar tumors"), mesotheliomas, primary thymic carcinomas, endodermal choristomas of the interatrial myocardium, peripheral cholangiocarcinoma, adrenocortical carcinoma, adenocarcinomas of the urinary bladder, mucinous and "rhabdoid" tumors of the ovaries, rete testis adenocarcinomas, interdigitating dendritic-cell sarcoma of lymph nodes, selected sweat gland carcinomas, cutaneous Merkel cell carcinoma, primary dermal and subcutaneous melanoma, mucosal and visceral melanomas, epithelioid sarcoma, clear-cell sarcoma, and adamantinoma of long bones...
November 17, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29135517/myb-translocation-status-in-salivary-gland-epithelial-myoepithelial-carcinoma-evaluation-of-classic-variant-and-hybrid-forms
#14
Justin A Bishop, William H Westra
Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. Adenoid cystic carcinoma (AdCC) is also a biphasic tumor comprised of ductal and myoepithelial cells, but these components tend to be arranged in a more cribriform pattern. The occurrence of "hybrid carcinomas" that show mixed patterns of EMC and AdCC raises questions about the relationship of these morphologically overlapping but clinically distinct tumors...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29131559/diagnostic-challenges-and-problem-cases-in-salivary-gland-cytology-a-20-year-experience
#15
Sajad Salehi, Zahra Maleki
BACKGROUND: Fine-needle aspiration (FNA) is routinely performed to evaluate salivary gland lesions, and provides valuable information regarding the cytomorphologic features of the lesions. Occasionally, there are overlaps between benign and malignant conditions due to heterogeneity of the cell types, metaplastic changes, and sampling issues. Herein, the authors present a retrospective study of diagnostic pitfalls in salivary gland cytology and the simulating conditions. METHODS: A 20-year retrospective review (1995-2015) of medical records was performed searching for the cytology reports of patients who underwent FNA of the salivary gland with the words "amendment" or "revision...
November 13, 2017: Cancer
https://www.readbyqxmd.com/read/29116049/pleomorphic-adenoma-the-results-of-a-retrospective-analysis-of-104-patients-treated-at-the-clinical-department-of-cranio-maxillofacial-surgery-clinic-of-otolaryngology-and-laryngologic-oncology-of-the-military-institute-of-medicine
#16
Michał Korba, Aldona Chloupek, Jarosław Dąbrowski, Tomasz Piętka, Wojciech Domański, Barbara Biernacka, Wojciech Leśniak
Pleomorphic adenoma, also known as tumor mixtus, is one of the most common types of benign neoplasm of the salivary gland, which presents as a slow growing, painless tumor. Major salivary glands are the typical localization of this neoplasm. It rarely undergoes malignant transformation, however may recur locally post resection. In this study, we present the results of a retrospective analysis of 104 patients treated at the Clinical Department of Cranio-Maxillofacial Surgery, Clinic of Otolaryngology and Laryngologic Oncology of the Military Institute of Medicine between 2004 and 2015 due to pleomorphic adenoma...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29076877/the-role-of-molecular-testing-in-the-differential-diagnosis-of-salivary-gland-carcinomas
#17
Alena Skálová, Göran Stenman, Roderick H W Simpson, Henrik Hellquist, David Slouka, Tomas Svoboda, Justin A Bishop, Jennifer L Hunt, Ken-Ichi Nibu, Alessandra Rinaldo, Vincent Vander Poorten, Kenneth O Devaney, Petr Steiner, Alfio Ferlito
Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of salivary gland carcinomas with a focus on their distinctive genomic characteristics. Mammary analog secretory carcinoma is a recently described entity characterized by a t(12;15)(p13;q25) translocation resulting in an ETV6-NTRK3 fusion...
February 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29076874/clear-cell-carcinoma-of-salivary-glands-is-frequently-p16-positive-a-pitfall-in-the-interpretation-of-oropharyngeal-biopsies
#18
Justin A Bishop, Lisa M Rooper, Simion I Chiosea, William H Westra
Clear cell carcinoma (CCC) is a low-grade malignancy that commonly arises in minor salivary glands of the oropharynx and other sites. EWSR1-ATF1 gene fusions seem to be specific for this salivary neoplasm. Testing for EWSR1-ATF1 has expanded the histologic spectrum of CCC. As one important example, many CCCs have a predominantly squamous phenotype with few clear cells, a finding that can cause confusion with squamous cell carcinoma (SqCC). P16 immunohistochemical staining to determine human papillomavirus (HPV) status has become standard practice for all oropharyngeal carcinomas showing squamous differentiation...
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29053216/-suspicious-salivary-gland-fna-risk-of-malignancy-and-interinstitutional-variability
#19
Zahra Maleki, James Adam Miller, Seyedeh Elham Arab, Guido Fadda, Ping Bo, Olga Wise, Esther Diana Rossi, Nirag Jhala, Chandra Ashish, Syed Z Ali, He Wang
BACKGROUND: Fine-needle aspiration (FNA) cytology is well accepted as a safe, reliable, minimally invasive, and cost-effective method for the diagnosis of salivary gland lesions. Salivary gland neoplasms are often difficult to diagnose because of morphologic heterogeneity and a variety of epithelial metaplastic changes. Hence, a number of salivary gland FNA specimens yield indeterminate results. For indeterminate FNA specimens, the suspicious-for-malignancy (SFM) category is used when a specific neoplasm falls short in quantity or quality for the criteria for malignancy...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29042745/immunoexpression-of-ki-67-and-endoglin-corroborating-hamartomatous-nature-of-sialoangiolipoma
#20
Swagatika Panda, Ipsita Mohanty, Alkananda Sahoo, Neeta Mohanty, Santosh Subudhi
Mesenchymal neoplasms of salivary gland including adipocytes are relatively uncommon entity classified as monophasic and biphasic. Sialolipoma, a biphasic mesenchymal salivary gland neoplasm, with a prominent vascularity designated as sialoangiolipoma (SAL) is a recently discussed entity with debates on the hamartomatous nature of the lesion. We have endorsed the hamartomatous nature through evaluating the immunoexpression of Ki-67 and endoglin in SAL in hard palate of a 60-year-old patient. To the best of our knowledge, this would be the second case of SAL in hard palate in a global platform...
July 2017: Contemporary Clinical Dentistry
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