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https://www.readbyqxmd.com/read/29445618/comparative-oncology-integrating-human-and-veterinary-medicine
#1
REVIEW
Faheem Sultan, Bilal Ahmad Ganaie
Cancer constitutes the major health problem both in human and veterinary medicine. Comparative oncology as an integrative approach offers to learn more about naturally occurring cancers across different species. Canine models have many advantages as they experience spontaneous disease, have many genes similar to human genes, five to seven-fold accelerated ageing compared to humans, respond to treatments similarly as humans do and health care levels second only to humans. Also, the clinical trials in canines could generate more robust data, as their spontaneous nature mimics real-life situations and could be translated to humans...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29440173/canine-research-to-benefit-humans-and-dogs-alike
#2
(no author information available yet)
The Jackson Laboratory recently launched the Tallwood Canine Cancer Research Initiative, in which tumor samples from dogs will be collected to create patient-derived xenografts in mice. These models, and their accompanying genome sequences, can then be shared with researchers around the world. The initiative's goal is to learn more about the biology of human cancers through comparative genomic analyses.
February 13, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29438432/cross-detection-for-odor-of-metabolic-waste-between-breast-and-colorectal-cancer-using-canine-olfaction
#3
In-Seok Seo, Hwan-Gon Lee, Bonkon Koo, Chin Su Koh, Hae-Yong Park, Changkyun Im, Hyung-Cheul Shin
Although several studies have been performed to detect cancer using canine olfaction, none have investigated whether canine olfaction trained to the specific odor of one cancer is able to detect odor related to other unfamiliar cancers. To resolve this issue, we employed breast and colorectal cancer in vitro, and investigated whether trained dogs to odor related to metabolic waste from breast cancer are able to detect it from colorectal cancer, and vice versa. The culture liquid samples used in the cultivation of cancerous cells (4T1 and CT26) were employed as an experimental group...
2018: PloS One
https://www.readbyqxmd.com/read/29429487/dynamic-changes-in-dna-methylation-patterns-in-canine-lymphoma-cell-lines-demonstrated-by-genome-wide-quantitative-dna-methylation-analysis
#4
J Yamazaki, J Jelinek, S Hisamoto, A Tsukamoto, M Inaba
DNA methylation is the conversion of cytosine to 5-methylcytosine, leading to changes in the interactions between DNA and proteins. Methylation of cytosine-guanine (CpG) islands (CGIs) is associated with gene expression silencing of the involved promoter. Although studies focussing on global changes or a few single loci in DNA methylation have been performed in dogs with certain diseases, genome-wide analysis of DNA methylation is required to prospectively identify specific regions with DNA methylation change...
January 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29428540/in-vitro-assessment-of-the-interactions-of-dopamine-%C3%AE-hydroxylase-inhibitors-with-human-p-glycoprotein-and-breast-cancer-resistance-protein
#5
Joana Bicker, Gilberto Alves, Ana Fortuna, Patrício Soares-da-Silva, Amílcar Falcão
Inhibition of the biosynthesis of noradrenaline is a currently explored strategy for the treatment of hypertension, congestive heart failure and pulmonary arterial hypertension. While some dopamine β-hydroxylase (DBH) inhibitors cross the blood-brain barrier (BBB) and cause central as well as peripheral effects (nepicastat), others have limited access to the brain (etamicastat, zamicastat). In this context, peripheral selectivity is clinically advantageous, in order to prevent alterations of noradrenaline levels in the CNS and the occurrence of adverse central effects...
February 8, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29422309/diagnostic-utility-of-cytokeratin-5-for-the-identification-of-proliferative-inflammatory-atrophy-in-the-canine-prostate
#6
C Palmieri, M Story, F Z X Lean, S H Akter, V Grieco, A M De Marzo
Proliferative inflammatory atrophy (PIA), which is comprised of highly proliferative but atrophic prostate epithelial cells in association with chronic inflammation, is considered a risk lesion for prostate cancer in men, while its role in canine prostate carcinogenesis is still unknown. We evaluated the value of immunohistochemical labelling for the basal cell marker cytokeratin-5 (CK5) in identifying PIA lesions in 87 samples of formalin-fixed and paraffin wax-embedded canine prostate. Canine PIA showed cytological features identical to the human counterpart and in most cases was associated with chronic lymphoplasmacytic inflammation...
January 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29415922/increased-expression-of-the-stromal-fibroblast-secreted-periostin-in-canine-squamous-cell-carcinomas
#7
Takayuki Mineshige, Kikumi Ogihara, Junichi Kamiie, Go Sugahara, James Ken Chambers, Kazuyuki Uchida, Hiroo Madarame, Kinji Shirota
Canine squamous cell carcinoma (SCC) shows highly invasive and locally destructive growth. In animal models and human cancer cases, periostin plays a critical role in the enhancement of cancer growth; however, the mechanism of involvement in canine cancers remains unknown. The aim of this study was to examine the involvement of periostin in the pathophysiology of SCC in dogs. We examined the localization of periostin and periostin-producing cells in 20 SCC and three squamous papilloma specimens. Furthermore, we focused on transforming growth factor (TGF)-β1, which was assumed to be an inducing factor of periostin, using culture cells...
February 6, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29408871/association-of-cancer-related-mortality-age-and-gonadectomy-in-golden-retriever-dogs-at-a-veterinary-academic-center-1989-2016
#8
Michael S Kent, Jenna H Burton, Gillian Dank, Danika L Bannasch, Robert B Rebhun
Golden retriever dogs have been reported to have an increased prevalence of cancer compared to other breeds. There is also controversy over the effect spay or neuter status might have on longevity and the risk for developing cancer. The electronic medical records system at an academic center was searched for all dogs who had a necropsy exam from 1989-2016. 9,677 canine necropsy examinations were completed of which 655 were golden retrievers. Age was known for 652 with a median age of death 9.15 years. 424 of the 652 (65...
2018: PloS One
https://www.readbyqxmd.com/read/29408808/pain-control-through-selective-chemo-axotomy-of-centrally-projecting-trpv1-sensory-neurons
#9
Matthew R Sapio, John K Neubert, Danielle M LaPaglia, Dragan Maric, Jason M Keller, Stephen J Raithel, Eric L Rohrs, Ethan M Anderson, John A Butman, Robert M Caudle, Dorothy C Brown, John D Heiss, Andrew J Mannes, Michael J Iadarola
Transient vanilloid potential 1 (TRPV1) agonists are emerging as highly efficacious non-opioid analgesics in preclinical studies. These drugs selectively lesion TRPV1+ primary sensory afferents, which are responsible for the transmission of many noxious stimulus modalities. Resiniferatoxin (RTX) is a very potent and selective TRPV1 agonist and is a promising candidate for treating many types of pain. Recent work establishing intrathecal application of RTX for the treatment of pain resulting from advanced cancer has demonstrated profound analgesia in client-owned dogs with osteosarcoma...
February 6, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29393972/evaluation-of-microrna-stability-in-feces-from-healthy-dogs
#10
Susanna Cirera, Line M Willumsen, Thea T Johansen, Lise N Nielsen
BACKGROUND: Gastrointestinal cancer accounts for approximately 8% of all canine malignancies. Early detection of cancer may have a tremendous impact on both treatment options and prognosis. MicroRNAs (miRNAs), a class of noncoding RNAs that can be found stably expressed in body fluids and feces, have been suggested as valuable human cancer biomarkers. OBJECTIVES: The purpose of the study was to investigate the feasibility of detecting miRNAs in canine feces and to determine the miRNA stability in fecal samples stored at different temperatures for different duration...
February 2, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29385676/naturally-occurring-canine-melanoma-as-a-predictive-comparative-oncology-model-for-human-mucosal-and-other-triple-wild-type-melanomas
#11
REVIEW
Belen Hernandez, Hibret A Adissu, Bih-Rong Wei, Helen T Michael, Glenn Merlino, R Mark Simpson
Melanoma remains mostly an untreatable fatal disease despite advances in decoding cancer genomics and developing new therapeutic modalities. Progress in patient care would benefit from additional predictive models germane for human disease mechanisms, tumor heterogeneity, and therapeutic responses. Toward this aim, this review documents comparative aspects of human and naturally occurring canine melanomas. Clinical presentation, pathology, therapies, and genetic alterations are highlighted in the context of current basic and translational research in comparative oncology...
January 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29378221/canine-sarcomas-as-a-surrogate-for-the-human-disease
#12
REVIEW
Daniel L Gustafson, Dawn L Duval, Daniel P Regan, Douglas H Thamm
Pet dogs are becoming increasingly recognized as a population with the potential to inform medical research through their treatment for a variety of maladies by veterinary health professionals. This is the basis of the One Health initiative, supporting the idea of collaboration between human and animal health researchers and clinicians to study spontaneous disease processes and treatment in animals to inform human health. Cancer is a major health burden in pet dogs, accounting for approximately 30% of deaths across breeds...
January 26, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29377654/peptide-mediated-targeting-mesoporous-silica-nanoparticles-a-novel-tool-for-fighting-bladder-cancer
#13
Sean K Sweeney, Yi Luo, Michael A O'Donnell, Jose G Assouline
Transitional cell carcinoma of the bladder is particularly devastating due to its high rate of recurrence and difficulty in retention of treatments within the bladder. Current cystoscopic approaches to detect and stage the tumor are limited by the penetrative depth of the cystoscope light source, and intravesical dyes that highlight tumors for surgical resection are non-specific. To address the needs for improved specificity in tumor detection and follow-up, we report on a novel technology relying on the engineered core of mesoporous silica (MSN) with surface modifications that generate contrast in fluorescence and magnetic resonance imaging (MRI)...
February 2017: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29360854/diagnostic-efficacy-of-smear-cytology-and-robinson-s-cytological-grading-of-canine-mammary-tumors-with-respect-to-histopathology-cytomorphometry-metastases-and-overall-survival
#14
Izabella Dolka, Michał Czopowicz, Anna Gruk-Jurka, Agata Wojtkowska, Rafał Sapierzyński, Piotr Jurka
Cytology is a simple, rapid, and inexpensive method used for pre-operative diagnosis of canine mammary tumors (CMTs) in veterinary practice. Studies related to human breast cancer showed the Robinson's grading system-established for invasive ductal carcinoma, not otherwise specified (IDC, NOS) and used on cytological material-to not only closely correspond to the histopathological grading but also be helpful in assessing prognosis and selecting most suitable treatments before surgery. The objectives of this study were: to evaluate the accuracy of cytological diagnosis and cytological Robinson's grading system compared to the histopathological examination of CMTs; to compare of cytological features and cytomorphometric parameters with tumor behavior, as well as cytological and histological grading; and to determine an association of the Robinson's grading system and cytological background details with metastases, and patients' survival...
2018: PloS One
https://www.readbyqxmd.com/read/29314561/biodistribution-and-tolerance-of-intravenous-iodine-131-labelled-hypericin-in-healthy-dogs
#15
E Abma, K Peremans, F De Vos, T Bosmans, A M Kitshoff, S Daminet, Y Ni, R Dockx, H de Rooster
Hypericin (Hyp) is a necrosis-avid compound that can be efficiently labelled with radioiodine for both diagnostic and therapeutic purposes. Before 131 I-Hyp can be considered as a clinically useful drug in a combination therapy for canine cancer patients, evaluation of its toxicity is necessary. The aim of this study was to investigate the biodistribution and tolerance of a single dose administration of 131 I-Hyp. Three healthy dogs were included. 131 I-Hyp at a dose of 0.2 mg/kg and an activity of 185 MBq was intravenously injected...
January 4, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29305964/in-vitro-and-in-vivo-characterization-of-stem-like-cells-from-canine-osteosarcoma-and-assessment-of-drug-sensitivity
#16
Monica Gatti, Agnese Solari, Alessandra Pattarozzi, Chiara Campanella, Stefano Thellung, Lorella Maniscalco, Raffaella De Maria, Roberto Würth, Alessandro Corsaro, Adriana Bajetto, Alessandra Ratto, Angelo Ferrari, Antonio Daga, Federica Barbieri, Tullio Florio
CSC self-renewing and drug resistance cause treatment failure and tumor recurrence. Osteosarcoma is an aggressive bone tumor characterized by biological and molecular heterogeneity, possibly dependent on cancer stem cells (CSCs). CSC identification in osteosarcoma and their efficient targeting are still open questions. Spontaneous canine osteosarcoma shares clinical and biological features with the human tumors, representing a model for translational studies. We characterized three CSC-enriched canine osteosarcoma cultures...
January 3, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29235249/anticancer-effects-of-resveratrol-in-canine-hemangiosarcoma-cell-lines
#17
A Carlson, K S Alderete, M K O Grant, D M Seelig, L C Sharkey, B N M Zordoky
Hemangiosarcoma (HSA) is a highly malignant tumour with aggressive biological behaviour. HSAs are more common in dogs than other domestic animals. The median survival time of dogs with HSA remains short, even with chemotherapy and surgery. Therefore, there is a critical need to improve the adjuvant chemotherapeutic regimens to improve clinical outcomes in dogs with HSA. Resveratrol has been shown to possess strong anti-proliferative and/or pro-apoptotic properties in human cancer cell lines. Nevertheless, the potential anticancer effects of resveratrol have not been reported in canine HSAs...
December 13, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29226073/cloning-of-canine-ku80-and-its-localization-and-accumulation-at-dna-damage-sites
#18
Manabu Koike, Yasutomo Yutoku, Aki Koike
Molecularly targeted therapies have high specificity and significant cancer-killing effect. However, their antitumor effect might be greatly diminished by variation in even a single amino acid in the target site, as it occurs, for example, as a consequence of SNPs. Increasing evidence suggests that the DNA repair protein Ku80 is an attractive target molecule for the development of next-generation radiosensitizers for human cancers. However, the localization, post-translational modifications (PTMs), and complex formation of Ku80 have not been elucidated in canines...
December 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29215573/the-use-of-liposomes-and-nanoparticles-as-drug-delivery-systems-to-improve-cancer-treatment-in-dogs-and-cats
#19
REVIEW
Katarzyna Zabielska-Koczywąs, Roman Lechowski
BACKGROUND: Cancer remains a leading cause of death in companion animals. In human medicine, liposomes and nanoparticles have been extensively investigated as drug delivery systems (DDS) for anticancer agents due to their ability to target cancerous cells and reduce the negative side effects of free cytostatic drugs. In this review, the authors discuss the results of clinical trials using liposomes and polymer-based nanoparticles as DDS to improve cancer treatment in dogs and cats, indicating which ones seem worth further evaluation...
December 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29207991/investigation-of-c-kit-and-ki67-expression-in-normal-preneoplastic-and-neoplastic-canine-prostate
#20
Carlos Eduardo Fonseca-Alves, Priscilla Emiko Kobayashi, Chiara Palmieri, Renée Laufer-Amorim
BACKGROUND: c-KIT expression has been related to bone metastasis in human prostate cancer, but whether c-KIT expression can be similarly classified in canine prostatic tissue is unknown. This study assessed c-KIT and Ki67 expression in canine prostate cancer (PC). c-KIT gene and protein expression and Ki67 expression were evaluated in forty-four canine prostatic tissues by immunohistochemistry, RT-qPCR and western blot. Additionally, we have investigated c-KIT protein expression by immunoblotting in two primary canine prostate cancer cell lines...
December 6, 2017: BMC Veterinary Research
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