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https://www.readbyqxmd.com/read/28434689/early-childhood-transmission-of-hepatitis-b-prior-to-the-first-hepatitis-b-vaccine-dose-is-rare-among-babies-born-to-hiv-infected-and-non-hiv-infected-mothers-in-gulu-uganda
#1
E Seremba, J P Van Geertruyden, R Ssenyonga, C K Opio, J M Kaducu, J B Sempa, R Colebunders, P Ocama
BACKGROUND: Hepatitis B (HBV) in sub-Saharan Africa is believed to be horizontally acquired. However, because of the high HBV prevalence in northern Uganda, no hepatitis B vaccination at birth and no access to HBV immunoglobulin, we hypothesize that vertical transmission also could also play an important role. We therefore investigated the incidence of HBV among babies presenting for their first HBV vaccine dose in Gulu, Uganda. METHODS: We recruited mothers and their babies (at least 6-week old) presenting for their postnatal care and first HBV vaccine dose respectively...
May 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28402554/does-how-the-patient-feels-matter-a-prospective-observational-study-of-the-outcome-of-acutely-ill-medical-patients-who-feel-their-condition-has-improved-on-their-first-re-assessment-after-admission-to-hospital
#2
Martin Otyek Opio, George Mutiibwa, John Kellett, Mikkel Brabrand
Background: although asking how a patient feels is the first enquiry most clinicians make the value of the answer has never been examined in acutely ill patients. Methods: prospective observational study that compared the predictive value of how well acutely ill medical patients felt after admission to a resource poor sub-Saharan hospital with their mental alertness, mobility, and vital signs. Results: : 403 patients were studied. Patients who felt better when re-assessed 18...
April 11, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28318241/mitigating-greenhouse-gas-and-ammonia-emissions-from-swine-manure-management-a-system-analysis
#3
Yue Wang, Hongmin Dong, Zhiping Zhu, Pierre J Gerber, Hongwei Xin, Pete Smith, Carolyn Opio, Henning Steinfeld, Dave Chadwick
Gaseous emissions from animal manure are considerable contributor to global ammonia (NH3) and agriculture greenhouse gas (GHG) emissions. Given the demand to promote mitigation of GHGs while fostering sustainable development of the Paris Agreement, an improvement of management systems is urgently needed to help mitigate climate change and to improve atmospheric air quality. This study presents a meta-analysis and an integrated assessment of gaseous emissions and mitigation potentials for NH3, methane (CH4), and nitrous oxide (N2O) (direct and indirect) losses from four typical swine manure management systems (MMSs)...
March 29, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28235461/how-well-are-pulses-measured-practice-based-evidence-from-an-observational-study-of-acutely-ill-medical-patients-during-their-hospital-admission
#4
Martin Otyek Opio, John Kellett
INTRODUCTION: although taking a radial pulse is considered to be an essential clinical skill there have been few reports on how well it is measured in clinical practice, and how its accuracy and precision are influenced by rate, rhythm and blood pressure. METHODS: this study is a retrospective quality audit carried out as part of a larger ongoing prospective observational trial. The radial pulse rates recorded by two research nurses were compared with the ECG heart rates measured on acutely ill medical patients during their admission to a resource poor hospital in sub-Saharan Africa...
February 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28200031/combatting-global-infectious-diseases-a-network-effect-of-specimen-referral-systems
#5
Peter N Fonjungo, George A Alemnji, Yenew Kebede, Alex Opio, Christina Mwangi, Thomas J Spira, R Suzanne Beard, John N Nkengasong
No abstract text is available yet for this article.
February 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28046081/correction-modeling-the-impact-of-uganda-s-safe-male-circumcision-program-implications-for-age-and-regional-targeting
#6
Katharine Kripke, Andrea Vazzano, William Kirungi, Joshua Musinguzi, Alex Opio, Rhobbinah Ssempebwa, Susan Nakawunde, Sheila Kyobutungi, Juliet N Akao, Fred Magala, George Mwidu, Delivette Castor, Emmanuel Njeuhmeli
[This corrects the article DOI: 10.1371/journal.pone.0158693.].
2017: PloS One
https://www.readbyqxmd.com/read/27958281/evolution-after-anti-tnf-discontinuation-in-patients-with-inflammatory-bowel-disease-a-multicenter-long-term-follow-up-study
#7
M J Casanova, M Chaparro, V García-Sánchez, O Nantes, E Leo, M Rojas-Feria, A Jauregui-Amezaga, S García-López, J M Huguet, F Arguelles-Arias, M Aicart, I Marín-Jiménez, M Gómez-García, F Muñoz, M Esteve, L Bujanda, X Cortés, J Tosca, J R Pineda, M Mañosa, J Llaó, J Guardiola, I Pérez-Martínez, C Muñoz, Y González-Lama, J Hinojosa, J M Vázquez, M P Martinez-Montiel, G E Rodríguez, R Pajares, M F García-Sepulcre, A Hernández-Martínez, J L Pérez-Calle, B Beltrán, D Busquets, L Ramos, F Bermejo, J Barrio, M Barreiro-de Acosta, O Roncedo, X Calvet, D Hervías, F Gomollón, M Domínguez-Antonaya, G Alcaín, B Sicilia, C Dueñas, A Gutiérrez, R Lorente-Poyatos, M Domínguez, S Khorrami, C Muñoz, C Taxonera, A Rodríguez-Pérez, A Ponferrada, M Van Domselaar, M L Arias-Rivera, O Merino, E Castro, J M Marrero, M Martín-Arranz, B Botella, L Fernández-Salazar, D Monfort, V Opio, A García-Herola, M Menacho, P Ramírez-de la Piscina, D Ceballos, P Almela, M Navarro-Llavat, V Robles-Alonso, A B Vega-López, I Moraleja, M T Novella, C Castaño-Milla, A Sánchez-Torres, J M Benítez, C Rodríguez, L Castro, E Garrido, E Domènech, E García-Planella, J P Gisbert
OBJECTIVES: The aims of this study were to assess the risk of relapse after discontinuation of anti-tumor necrosis factor (anti-TNF) drugs in patients with inflammatory bowel disease (IBD), to identify the factors associated with relapse, and to evaluate the overcome after retreatment with the same anti-TNF in those who relapsed. METHODS: This was a retrospective, observational, multicenter study. IBD patients who had been treated with anti-TNFs and in whom these drugs were discontinued after clinical remission was achieved were included...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27931922/qualitative-analysis-of-the-risks-and-practices-associated-with-the-spread-of-african-swine-fever-within-the-smallholder-pig-value-chains-in-uganda
#8
Michel Dione, Emily Ouma, Felix Opio, Brian Kawuma, Danilo Pezo
A study was undertaken between September 2014 and December 2014 to assess the perceptions of smallholder pig value chain actors of the risks and practices associated with the spread of African swine fever (ASF) disease within the pig value chains. Data was collected from 136 value chain actors and 36 key informants through 17 group discussions and two key informant interview (KII) sessions respectively using Participatory Rural Appraisal (PRA) tools. Results from this study revealed that according to value chain actors and stakeholders, the transporting, slaughtering, and collecting/bulking nodes represent the highest risk, followed by the inputs and services (feeds and drugs) supply nodes...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27862720/antitumor-activity-of-opiorphin-sialorphin-and-their-conjugates-with-a-peptide-klaklakklaklak
#9
Elżbieta Kamysz, Ryszard Smolarczyk, Tomasz Cichoń, Magdalena Jarosz-Biej, Emilia Sikorska, Małgorzata Sobocińska, Maciej Jaśkiewicz, Wojciech Kamysz
This is the study on the effect of opiorphin, sialorphin and their analogs on antitumor activity. We demonstrated that conjugation of opiorphin and sialorphin with a proapoptotic, antimicrobial peptide klak (klaklakklaklak) led to compounds (opio-klak and sialo-klak) that were cytotoxic against cancer cells (LN18, PC3, A549, HCT116 and B10-F16) in the MTT test. The conjugated analogs were designed to increase the effectiveness of the peptide. The opio-klak derivative was the most effective in the in vitro assays and led to a decrease in viability of cancer cells over time as compared with that of untreated controls...
November 2016: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/27859220/farmland-biodiversity-and-agricultural-management-on-237-farms-in-13-european-and-two-african-regions
#10
Gisela Lüscher, Youssef Ammari, Aljona Andriets, Siyka Angelova, Michaela Arndorfer, Debra Bailey, Katalin Balázs, Marion Bogers, Robert G H Bunce, Jean-Philippe Choisis, Peter Dennis, Mario Díaz, Tetyana Dyman, Sebastian Eiter, Wendy Fjellstad, Mariecia Fraser, Jürgen K Friedel, Salah Garchi, Ilse R Geijzendorffer, Tiziano Gomiero, Guillermo González-Bornay, Yana Guteva, Felix Herzog, Philippe Jeanneret, Rob H G Jongman, Max Kainz, Norman Kwikiriza, María Lourdes López Díaz, Gerardo Moreno, Pip Nicholas-Davies, Charles Nkwiine, Julius Opio, Maurizio G Paoletti, László Podmaniczky, Philippe Pointereau, Fernando Pulido, Jean-Pierre Sarthou, Manuel K Schneider, Tahar Sghaier, Norman Siebrecht, Siyka Stoyanova, Sebastian Wolfrum, Sergiy Yashchenko, Harald Albrecht, András Báldi, Márta Belényesi, Jacinto Benhadi-Marin, Theo Blick, Serge Buholzer, Csaba Centeri, Norma Choisis, Gérard Cuendet, Hendrika J De Lange, Sylvain Déjean, Christo Deltshev, Darío J Díaz Cosín, Wenche Dramstad, Zoltán Elek, Gunnar Engan, Konstantin Evtushenko, Eszter Falusi, Oliver-D Finch, Thomas Frank, Federico Gavinelli, David Genoud, Phillipa K Gillingham, Viktor Grónás, Mónica Gutiérrez, Werner Häusler, Xaver Heer, Thomas Hübner, Marco Isaia, Gergely Jerkovich, Juan B Jesus, Esezah Kakudidi, Eszter Kelemen, Nóra Koncz, Eszter Kovacs, Anikó Kovács-Hostyánszki, Luisa Last, Toshko Ljubomirov, Klaus Mandery, Josef Mayr, Atle Mjelde, Christoph Muster, Juri Nascimbene, Johann Neumayer, Frode Ødegaard, Francisco Javier Ortiz Sánchez, Marie-Louise Oschatz, Susanne Papaja-Hülsbergen, Mauro Paschetta, Mark Pavett, Céline Pelosi, Károly Penksza, Reidun Pommeresche, Victor Popov, Volodymyr Radchenko, Nina Richner, Susanne Riedel, John Scullion, Daniele Sommaggio, Ottó Szalkovszki, Erich Szerencsits, Dolores Trigo, Jim Vale, Ruud van Kats, Angel Vasilev, Andrew E Whittington, Jerylee Wilkes-Allemann, Tommaso Zanetti
Farmland is a major land cover type in Europe and Africa and provides habitat for numerous species. The severe decline in farmland biodiversity of the last decades has been attributed to changes in farming practices, and organic and low-input farming are assumed to mitigate detrimental effects of agricultural intensification on biodiversity. Since the farm enterprise is the primary unit of agricultural decision making, management-related effects at the field scale need to be assessed at the farm level. Therefore, in this study, data were collected on habitat characteristics, vascular plant, earthworm, spider, and bee communities and on the corresponding agricultural management in 237 farms in 13 European and two African regions...
June 2016: Ecology
https://www.readbyqxmd.com/read/27761581/evaluation-of-an-overlapping-pubic-and-ischiatic-osteotomy-for-the-improvement-of-acetabular-ventroversion-in-dogs-an-ex-vivo-study
#11
Julie A Gervais, James K Roush, David S Biller
OBJECTIVES: To assess the potential of a new single-session surgical procedure, the overlapping pubic and ischiatic osteotomy (OPIO) for modification of bilateral hip conformation. We hypothesized that OPIO would be simple to perform with currently available surgical equipment, through a single surgical approach, with minimal potential morbidity, and that it would allow adequate simultaneous bilateral improvement of coxofemoral joint conformation in patients at risk of canine hip dysplasia...
November 23, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27518562/astrocytic-insulin-signaling-couples-brain-glucose-uptake-with-nutrient-availability
#12
Cristina García-Cáceres, Carmelo Quarta, Luis Varela, Yuanqing Gao, Tim Gruber, Beata Legutko, Martin Jastroch, Pia Johansson, Jovica Ninkovic, Chun-Xia Yi, Ophelia Le Thuc, Klara Szigeti-Buck, Weikang Cai, Carola W Meyer, Paul T Pfluger, Ana M Fernandez, Serge Luquet, Stephen C Woods, Ignacio Torres-Alemán, C Ronald Kahn, Magdalena Götz, Tamas L Horvath, Matthias H Tschöp
We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic glucose metabolism. Postnatal ablation of insulin receptors (IRs) in glial fibrillary acidic protein (GFAP)-expressing cells affects hypothalamic astrocyte morphology, mitochondrial function, and circuit connectivity. Accordingly, astrocytic IR ablation reduces glucose-induced activation of hypothalamic pro-opio-melanocortin (POMC) neurons and impairs physiological responses to changes in glucose availability...
August 11, 2016: Cell
https://www.readbyqxmd.com/read/27470028/estimates-of-global-regional-and-national-incidence-prevalence-and-mortality-of-hiv-1980-2015-the-global-burden-of-disease-study-2015
#13
Haidong Wang, Tim M Wolock, Austin Carter, Grant Nguyen, Hmwe Hmwe Kyu, Emmanuela Gakidou, Simon I Hay, Edward J Mills, Adam Trickey, William Msemburi, Matthew M Coates, Meghan D Mooney, Maya S Fraser, Amber Sligar, Joshua Salomon, Heidi J Larson, Joseph Friedman, Amanuel Alemu Abajobir, Kalkidan Hassen Abate, Kaja M Abbas, Mohamed Magdy Abd El Razek, Foad Abd-Allah, Abdishakur M Abdulle, Semaw Ferede Abera, Ibrahim Abubakar, Laith J Abu-Raddad, Niveen M E Abu-Rmeileh, Gebre Yitayih Abyu, Akindele Olupelumi Adebiyi, Isaac Akinkunmi Adedeji, Ademola Lukman Adelekan, Koranteng Adofo, Arsène Kouablan Adou, Oluremi N Ajala, Tomi F Akinyemiju, Nadia Akseer, Faris Hasan Al Lami, Ziyad Al-Aly, Khurshid Alam, Noore K M Alam, Deena Alasfoor, Saleh Fahed S Aldhahri, Robert William Aldridge, Miguel Angel Alegretti, Alicia V Aleman, Zewdie Aderaw Alemu, Rafael Alfonso-Cristancho, Raghib Ali, Ala'a Alkerwi, François Alla, Rajaa Mohammad, Salem Al-Raddadi, Ubai Alsharif, Elena Alvarez, Nelson Alvis-Guzman, Azmeraw T Amare, Alemayehu Amberbir, Adeladza Kofi Amegah, Walid Ammar, Stephen Marc Amrock, Carl Abelardo T Antonio, Palwasha Anwari, Johan Ärnlöv, Al Artaman, Hamid Asayesh, Rana Jawad Asghar, Reza Assadi, Suleman Atique, Lydia S Atkins, Euripide Frinel G Arthur Avokpaho, Ashish Awasthi, Beatriz Paulina Ayala Quintanilla, Umar Bacha, Alaa Badawi, Aleksandra Barac, Till Bärnighausen, Arindam Basu, Tigist Assefa Bayou, Yibeltal Tebekaw Bayou, Shahrzad Bazargan-Hejazi, Justin Beardsley, Neeraj Bedi, Derrick A Bennett, Isabela M Bensenor, Balem Demtsu Betsu, Addisu Shunu Beyene, Eesh Bhatia, Zulfiqar A Bhutta, Sibhatu Biadgilign, Boris Bikbov, Sait Mentes Birlik, Donal Bisanzio, Michael Brainin, Alexandra Brazinova, Nicholas J K Breitborde, Alexandria Brown, Michael Burch, Zahid A Butt, Julio Cesar Campuzano, Rosario Cárdenas, Juan Jesus Carrero, Carlos A Castañeda-Orjuela, Jacqueline Castillo Rivas, Ferrán Catalá-López, Hsing-Yi Chang, Jung-Chen Chang, Laxmikant Chavan, Wanqing Chen, Peggy Pei-Chia Chiang, Mirriam Chibalabala, Vesper Hichilombwe Chisumpa, Jee-Young Jasmine Choi, Devasahayam Jesudas Christopher, Liliana G Ciobanu, Cyrus Cooper, Tukur Dahiru, Solomon Abreha Damtew, Lalit Dandona, Rakhi Dandona, José das Neves, Pieter de Jager, Diego De Leo, Louisa Degenhardt, Robert P Dellavalle, Kebede Deribe, Amare Deribew, Don C Des Jarlais, Samath D Dharmaratne, Eric L Ding, Pratik Pinal Doshi, Tim R Driscoll, Manisha Dubey, Yousef Mohamed Elshrek, Iqbal Elyazar, Aman Yesuf Endries, Sergey Petrovich Ermakov, Babak Eshrati, Alireza Esteghamati, Imad D A Faghmous, Carla Sofia E Sa Farinha, Andre Faro, Maryam S Farvid, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Joao C Fernandes, Florian Fischer, Joseph Robert Ander Fitchett, Nataliya Foigt, Nancy Fullman, Thomas Fürst, Fortuné Gbètoho Gankpé, Teshome Gebre, Amanuel Tesfay Gebremedhin, Alemseged Aregay Gebru, Johanna M Geleijnse, Bradford D Gessner, Peter W Gething, Tsegaye Tewelde Ghiwot, Maurice Giroud, Melkamu Dedefo Gishu, Elizabeth Glaser, Shifalika Goenka, Amador Goodridge, Sameer Vali Gopalani, Atsushi Goto, Harish Chander Gugnani, Mark D C Guimaraes, Rahul Gupta, Rajeev Gupta, Vipin Gupta, Juanita Haagsma, Nima Hafezi-Nejad, Holly Hagan, Gessessew Bugssa Hailu, Randah Ribhi Hamadeh, Samer Hamidi, Mouhanad Hammami, Graeme J Hankey, Yuantao Hao, Hilda L Harb, Sivadasanpillai Harikrishnan, Josep Maria Haro, Kimani M Harun, Rasmus Havmoeller, Mohammad T Hedayati, Ileana Beatriz Heredia-Pi, Hans W Hoek, Masako Horino, Nobuyuki Horita, H Dean Hosgood, Damian G Hoy, Mohamed Hsairi, Guoqing Hu, Hsiang Huang, John J Huang, Kim Moesgaard Iburg, Bulat T Idrisov, Kaire Innos, Veena J Iyer, Kathryn H Jacobsen, Nader Jahanmehr, Mihajlo B Jakovljevic, Mehdi Javanbakht, Achala Upendra Jayatilleke, Panniyammakal Jeemon, Vivekanand Jha, Guohong Jiang, Ying Jiang, Tariku Jibat, Jost B Jonas, Zubair Kabir, Ritul Kamal, Haidong Kan, André Karch, Corine Kakizi Karema, Dimitris Karletsos, Amir Kasaeian, Anil Kaul, Norito Kawakami, Jeanne Françoise Kayibanda, Peter Njenga Keiyoro, Andrew Haddon Kemp, Andre Pascal Kengne, Chandrasekharan Nair Kesavachandran, Yousef Saleh Khader, Ibrahim Khalil, Abdur Rahman Khan, Ejaz Ahmad Khan, Young-Ho Khang, Jagdish Khubchandani, Yun Jin Kim, Yohannes Kinfu, Miia Kivipelto, Yoshihiro Kokubo, Soewarta Kosen, Parvaiz A Koul, Ai Koyanagi, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Veena S Kulkarni, G Anil Kumar, Dharmesh Kumar Lal, Hilton Lam, Jennifer O Lam, Sinead M Langan, Van C Lansingh, Anders Larsson, James Leigh, Ricky Leung, Yongmei Li, Stephen S Lim, Steven E Lipshultz, Shiwei Liu, Belinda K Lloyd, Giancarlo Logroscino, Paulo A Lotufo, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Mahdi Mahdavi, Marek Majdan, Azeem Majeed, Carla Makhlouf, Reza Malekzadeh, Chabila C Mapoma, Wagner Marcenes, Jose Martinez-Raga, Melvin Barrientos Marzan, Felix Masiye, Amanda J Mason-Jones, Bongani M Mayosi, Martin McKee, Peter A Meaney, Man Mohan Mehndiratta, Alemayehu B Mekonnen, Yohannes Adama Melaku, Peter Memiah, Ziad A Memish, Walter Mendoza, Atte Meretoja, Tuomo J Meretoja, Francis Apolinary Mhimbira, Ted R Miller, Joseph Mikesell, Mojde Mirarefin, Karzan Abdulmuhsin Mohammad, Shafiu Mohammed, Ali H Mokdad, Lorenzo Monasta, Maziar Moradi-Lakeh, Rintaro Mori, Ulrich O Mueller, Brighton Murimira, Gudlavalleti Venkata Satyanarayana Murthy, Aliya Naheed, Luigi Naldi, Vinay Nangia, Denis Nash, Haseeb Nawaz, Chakib Nejjari, Frida Namnyak Ngalesoni, Jean de Dieu Ngirabega, Quyen Le Nguyen, Muhammad Imran Nisar, Ole F Norheim, Rosana E Norman, Luke Nyakarahuka, Felix Akpojene Ogbo, In-Hwan Oh, Foluke Adetola Ojelabi, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, John Nelson Opio, Eyal Oren, Erika Ota, Mahesh Anand Padukudru, Hye-Youn Park, Jae-Hyun Park, Snehal T Patil, Scott B Patten, Vinod K Paul, Katherine Pearson, Emmanuel Kwame Peprah, Claudia C Pereira, Norberto Perico, Konrad Pesudovs, Max Petzold, Michael Robert Phillips, Julian David Pillay, Dietrich Plass, Suzanne Polinder, Farshad Pourmalek, David M Prokop, Mostafa Qorbani, Anwar Rafay, Kazem Rahimi, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, Sajjad Ur Rahman, Rajesh Kumar Rai, Sasa Rajsic, Usha Ram, Saleem M Rana, Paturi Vishnupriya Rao, Giuseppe Remuzzi, David Rojas-Rueda, Luca Ronfani, Gholamreza Roshandel, Ambuj Roy, George Mugambage Ruhago, Mohammad Yahya Saeedi, Rajesh Sagar, Muhammad Muhammad Saleh, Juan R Sanabria, Itamar S Santos, Rodrigo Sarmiento-Suarez, Benn Sartorius, Monika Sawhney, Aletta E Schutte, David C Schwebel, Soraya Seedat, Sadaf G Sepanlou, Edson E Servan-Mori, Masood Ali Shaikh, Rajesh Sharma, Jun She, Sara Sheikhbahaei, Jiabin Shen, Kenji Shibuya, Hwashin Hyun Shin, Inga Dora Sigfusdottir, Naris Silpakit, Diego Augusto Santos Silva, Dayane Gabriele Alves Silveira, Edgar P Simard, Shireen Sindi, Jasvinder A Singh, Om Prakash Singh, Prashant Kumar Singh, Vegard Skirbekk, Karen Sliwa, Samir Soneji, Reed J D Sorensen, Joan B Soriano, David O Soti, Chandrashekhar T Sreeramareddy, Vasiliki Stathopoulou, Nicholas Steel, Bruno F Sunguya, Soumya Swaminathan, Bryan L Sykes, Rafael Tabarés-Seisdedos, Roberto Tchio Talongwa, Mohammad Tavakkoli, Bineyam Taye, Bemnet Amare Tedla, Tesfaye Tekle, Girma Temam Shifa, Awoke Misganaw Temesgen, Abdullah Sulieman Terkawi, Fisaha Haile Tesfay, Gizachew Assefa Tessema, Kiran Thapa, Alan J Thomson, Andrew L Thorne-Lyman, Ruoyan Tobe-Gai, Roman Topor-Madry, Jeffrey Allen Towbin, Bach Xuan Tran, Zacharie Tsala Dimbuene, Nikolaos Tsilimparis, Abera Kenay Tura, Kingsley Nnanna Ukwaja, Chigozie Jesse Uneke, Olalekan A Uthman, N Venketasubramanian, Sergey K Vladimirov, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Linhong Wang, Elisabete Weiderpass, Robert G Weintraub, Andrea Werdecker, Ronny Westerman, Tissa Wijeratne, James D Wilkinson, Charles Shey Wiysonge, Charles D A Wolfe, Sungho Won, John Q Wong, Gelin Xu, Ajit Kumar Yadav, Bereket Yakob, Ayalnesh Zemene Yalew, Yuichiro Yano, Mehdi Yaseri, Henock Gebremedhin Yebyo, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Chuanhua Yu, Shicheng Yu, Zoubida Zaidi, Maysaa El Sayed Zaki, Hajo Zeeb, Hao Zhang, Yong Zhao, Sanjay Zodpey, Leo Zoeckler, Liesl Joanna Zuhlke, Alan D Lopez, Christopher J L Murray
BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. METHODS: For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes...
August 2016: Lancet HIV
https://www.readbyqxmd.com/read/27411834/effect-of-maternal-helicobacter-pylori-infection-on-birth-weight-in-an-urban-community-in-uganda
#14
Ronald Wanyama, Mike N Kagawa, Kenneth C Opio, Rhona K Baingana
BACKGROUND: Helicobacter pylori, a widespread infection particularly in developing countries has been associated with many adverse effects during pregnancy including hyperemesis gravidarum, neural tube defects in newborns, intrauterine fetal growth restriction and miscarriage. We sought to document the effects of H. pylori infection on birth weight in a low-income setting in Kampala, Uganda. METHODS: This was a prospective cohort study conducted in Kampala between May 2012 and May 2013...
2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27410234/modeling-the-impact-of-uganda-s-safe-male-circumcision-program-implications-for-age-and-regional-targeting
#15
Katharine Kripke, Andrea Vazzano, William Kirungi, Joshua Musinguzi, Alex Opio, Rhobbinah Ssempebwa, Susan Nakawunde, Sheila Kyobutungi, Juliet N Akao, Fred Magala, George Mwidu, Delivette Castor, Emmanuel Njeuhmeli
BACKGROUND: Uganda aims to provide safe male circumcision (SMC) to 80% of men ages 15-49 by 2016. To date, only 2 million men have received SMC of the 4.2 million men required. In response to age and regional trends in SMC uptake, the country sought to re-examine its targets with respect to age and subnational region, to assess the program's progress, and to refine the implementation approach. METHODS AND FINDINGS: The Decision Makers' Program Planning Tool, Version 2...
2016: PloS One
https://www.readbyqxmd.com/read/27350934/the-burden-of-tetanus-in-uganda
#16
Barbara Nanteza, Moses Galukande, Jane Aceng, Joshua Musinguzi, Alex Opio, Anthony K Mbonye, Eddie Mukooyo, Prosper Behumize, Fredrick Makumbi
BACKGROUND: The successful scale-up of safe male circumcision (SMC) in Uganda has been hinged on client's safety and quality of services. However, after the recent three tetanus deaths after circumcision a review of all tetanus cases in one of the hospitals where the cases occurred was initiated. This was to ascertain the potential for an association between tetanus infection and circumcision. Routinely collected national data were also reviewed to determine the burden of tetanus in Uganda and contextualize these incidents...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27185416/reducing-emissions-from-agriculture-to-meet-the-2%C3%A2-%C3%A2-c-target
#17
Eva Wollenberg, Meryl Richards, Pete Smith, Petr Havlík, Michael Obersteiner, Francesco N Tubiello, Martin Herold, Pierre Gerber, Sarah Carter, Andrew Reisinger, Detlef P van Vuuren, Amy Dickie, Henry Neufeldt, Björn O Sander, Reiner Wassmann, Rolf Sommer, James E Amonette, Alessandra Falcucci, Mario Herrero, Carolyn Opio, Rosa Maria Roman-Cuesta, Elke Stehfest, Henk Westhoek, Ivan Ortiz-Monasterio, Tek Sapkota, Mariana C Rufino, Philip K Thornton, Louis Verchot, Paul C West, Jean-François Soussana, Tobias Baedeker, Marc Sadler, Sonja Vermeulen, Bruce M Campbell
More than 100 countries pledged to reduce agricultural greenhouse gas (GHG) emissions in the 2015 Paris Agreement of the United Nations Framework Convention on Climate Change. Yet technical information about how much mitigation is needed in the sector vs. how much is feasible remains poor. We identify a preliminary global target for reducing emissions from agriculture of ~1 GtCO2 e yr(-1) by 2030 to limit warming in 2100 to 2 °C above pre-industrial levels. Yet plausible agricultural development pathways with mitigation cobenefits deliver only 21-40% of needed mitigation...
December 2016: Global Change Biology
https://www.readbyqxmd.com/read/26777607/the-alertness-gait-and-mortality-of-severely-ill-patients-at-two-months-after-admission-to-a-resource-poor-sub-saharan-hospital-why-is-post-discharge-surveillance-not-routine-everywhere
#18
Barbara Nabayigga, John Kellett, Martin Otyek Opio
BACKGROUND: Mortality, the first level of the first tier of the Outcomes Measures Hierarchy used to assess the value of health care, is the only hospital outcome usually measured. Gait and alertness after discharge are important to patients; they capture much of the second level of the first tier of the hierarchy, and are required to more fully assess the benefits, value and quality of care. AIM: To assess the alertness, gait and mortality of severely ill patients at two months after admission to a resource poor sub-Saharan hospital...
March 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/26762158/60-years-of-pomc-from-the-prohormone-theory-to-pro-opiomelanocortin-and-to-proprotein-convertases-pcsk1-to-pcsk9
#19
REVIEW
Michel Chrétien, Majambu Mbikay
Pro-opiomelanocortin (POMC), is a polyprotein expressed in the pituitary and the brain where it is proteolytically processed into peptide hormones and neuropeptides with distinct biological activities. It is the prototype of multipotent prohormones. The prohormone theory was first suggested in 1967 when Chrétien and Li discovered γ-lipotropin and observed that (i) it was part of β-lipotropin (β-LPH), a larger polypeptide characterized 2 years earlier and (ii) its C-terminus was β-melanocyte-stimulating hormone (β-MSH)...
May 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/26680237/the-mortality-of-acutely-ill-medical-patients-for-up-to-60days-after-admission-to-a-resource-poor-hospital-in-sub-saharan-africa-compared-with-patients-of-similar-illness-severity-admitted-to-a-danish-regional-teaching-hospital-an-exploratory-observational
#20
COMPARATIVE STUDY
Barbara Nabayigga, John Kellett, Mikkel Brabrand, Martin Otyek Opio
BACKGROUND: The outcomes of patients with the same severity of illness in the developed and developing countries have not been compared. Illness severity can now be measured anywhere by the National Early Warning Score (NEWS). METHODS: An exploratory observational study that compared the 7, 30 and 60 days mortality of 195 Ugandan and 588 Danish acutely ill medical patients that had a NEWS >6 at the time of their admission to the hospital. The association of vital sign changes, alertness and mobility at admission on subsequent outcome was explored...
January 2016: European Journal of Internal Medicine
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