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https://www.readbyqxmd.com/read/29679590/phase-i-ii-pharmacokinetic-and-pharmacodynamic-evaluation-of-two-levonorgestrel-only-contraceptive-patches-in-a-multicenter-randomized-trial
#1
Carolyn L Westhoff, Beatrice A Chen, Jeffrey T Jensen, Kurt Barnhart, Michael Thomas, Stephanie Teal, Diana Blithe
OBJECTIVES: To evaluate the pharmacokinetic and pharmacodynamic effects of two novel levonorgestrel (LNG)-only contraceptive patches. STUDY DESIGN: This multi-center Phase I/II trial randomized participants to use a 7-day transdermal patch designed to deliver a 40 mcg or 75 mcg daily LNG dose for 11 consecutive weeks; randomization was stratified by body mass index (BMI) <32 or 32-40kg/m2 . Evaluations occurred twice weekly for 5weeks, then once weekly with supplemental visits for participants reporting a urinary LH surge...
April 18, 2018: Contraception
https://www.readbyqxmd.com/read/29678280/the-kisspeptin-receptor-a-key-g-protein-coupled-receptor-in-the-control-of-the-reproductive-axis
#2
REVIEW
Delphine Franssen, Manuel Tena-Sempere
The kisspeptin receptor, Kiss1R, also known as Gpr54, is a G protein-coupled receptor (GPCR), deorphanized in 2001, when it was recognized as canonical receptor for the Kiss1-derived peptides, kisspeptins. In 2003, inactivating mutations of Kiss1R gene were first associated to lack of pubertal maturation and hypogonadotropic hypogonadism in humans and rodents. These seminal findings pointed out the previously unsuspected, essential role of Kiss1R and its ligands in control of reproductive maturation and function...
April 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29676585/modified-hmg-stimulated-an-effective-option-in-endometrial-preparation-for-frozen-thawed-embryo-transfer-in-patients-with-normal-menstrual-cycles
#3
Pinxiu Huang, Lihong Wei, Xinlin Li, Zhong Lin
To evaluate the clinical efficacy of modified human menopausal gonadotropin (hMG) stimulated, hormone replacement therapy (HRT), natural cycling and letrozole ovulation induction during endometrial preparation for frozen-thawed embryo transfer (FET) in patients with normal menstrual cycles. This retrospective analysis included a total of 5070 cycles of patients with normal menstrual patterns who underwent FET between October 2009 and September 2015. The patients were divided into four groups according to the method of endometrial preparation for FET: 1838 cycles were natural, 1666 underwent HRT, 340 underwent letrozole ovulation induction and 1226 underwent modified hMG stimulated...
April 20, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29675034/relationship-between-the-estimated-breeding-values-for-litter-traits-at-birth-and-ovarian-and-embryonic-traits-and-their-additive-genetic-variance-in-gilts-at-35-days-of-pregnancy
#4
Carolina L A Da Silva, Han A Mulder, Marleen L W J Broekhuijse, Bas Kemp, Nicoline M Soede, Egbert F Knol
We investigated (1) the relationship between the estimated breeding values (EBVs) for litter traits at birth and ovulation rate (OR), average corpora luteal weight, uterine length and embryonic survival and development traits in gilts at 35 days of pregnancy by linear regression, (2) the genetic variance of OR, average corpora lutea (CL) weight, uterine length and embryonic survival and development traits at 35 days of pregnancy, and (3) the genetic correlations between these traits. Landrace ( n = 86) and Yorkshire × Landrace ( n = 304) gilts were inseminated and slaughtered at 35 days of pregnancy...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29674785/effects-of-prolonged-immunocontraception-on-the-breeding-behavior-of-american-bison
#5
Calvin L Duncan, Julie L King, Paul Stapp
In late 2009, the Catalina Island Conservancy began using fertility control to replace periodic removals to manage an introduced population of American bison ( Bison bison ) on the island. Through the application of the immunocontraceptive vaccine porcine zona pellucida (PZP), population growth was slowed within 1 year, and halted over time. In response to lingering questions about the use of PZP to manage large, free-ranging wildlife populations, we sought to determine the reversibility of PZP by ceasing the annual application to a subset of 15 bison cows and monitoring for subsequent calf arrival, and to document changes in the timing and length of the breeding season in response to PZP by monitoring breeding behavior and assessing fecal progesterone (FP) levels for all 60 resident cows over a 13-month period...
October 3, 2017: Journal of Mammalogy
https://www.readbyqxmd.com/read/29673662/the-influence-of-ovarian-hyperstimulation-drugs-on-morphometry-and-morphology-of-human-oocytes-in-icsi-program
#6
Fatemeh Taheri, Arezoo Alemzadeh Mehrizi, Mohammad Ali Khalili, Iman Halvaei
OBJECTIVE: To compare the influences of controlled ovarian hyperstimulation (COH) drugs using recombinant follicular stimulating hormone (rFSH) versus human menopausal gonadotropins (hMG) on morphometry and morphology of MII oocytes in ICSI cycles. MATERIALS AND METHODS: In this prospective study, 363 MII oocytes from 50 ICSI cycles with male factor infertility were evaluated. The patients were divided into two groups according to the protocols of COH: I- rFSH and II- hMG...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673000/effect-of-insemination-timing-on-pregnancy-outcome-in-association-with-female-age-sperm-motility-sperm-morphology-and-sperm-concentration-in-intrauterine-insemination
#7
Jisun Lee, Suna Hwang, Jaehun Lee, Junghyun Yoo, Dongmin Jang, Kyungjoo Hwang, Miran Kim
AIM: We investigated the effect of insemination timing on pregnancy outcomes in intrauterine insemination (IUI) cycles. METHODS: This is a retrospective study of 411 IUI cycles performed with a diagnosis of unexplained infertility and male factor infertility. The cycles were divided according to the interval between insemination and ovulation: ≤36 h, 36-37 h, 37-38 h and >38 h. The overall pregnancy rate, chemical pregnancy rate and clinical pregnancy rate were compared...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29672673/effects-of-preovulatory-estradiol-on-uterine-environment-and-conceptus-survival-from-fertilization-to-maternal-recognition-of-pregnancy
#8
Emmalee J Northrop, Jerica J J Rich, Robert A Cushman, Anthony K McNeel, Émerson M Soares, Kelsey Brooks, Thomas E Spencer, George A Perry
Preovulatory estradiol is known to impact embryo quality and survival. The objective of this study was to determine the effects of preovulatory estradiol on the uterine environment and conceptus survival through maternal recognition of pregnancy. Beef cows/heifers were AIed following induced ovulation. Cows were grouped into high and low preovulatory estradiol. Conceptuses were collected on d 16 nonsurgically (Rep 1; n = 20), or following slaughter (Rep 2; n = 29). Blood was collected to determine plasma glucose concentrations, and uterine luminal fluid (ULF) was analyzed for protein, glucose, and interferon tau concentrations...
April 17, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29668885/follicle-capacitation-a-meta-analysis-to-investigate-the-transcriptome-dynamics-following-fsh-decline-in-bovine-granulosa-cells
#9
David A Landry, Marc-André Sirard
In recent years, exciting progress was made to improve the embryo outcome after ovarian stimulation in domestic animals. The practice of follicle-stimulating hormone (FSH) withdrawal, which is defined as the period of time between the last injection of FSH and oocyte retrieval, resulted in embryo yields significantly superior. Since then, specific changes in the transcriptome of granulosa cells were associated with the increase and also the decline in oocyte developmental competence following the FSH decline...
April 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29667544/proteomic-markers-in-cervical-mucus
#10
Yolanda Fernandez-Hermida, Giuseppe Grande, Micaela Menarguez, Anna Laura Astorri, Rafael Azagra
Cervical Mucus (CM) is a viscous fluid produced by the cervical glands. It plays a key role in the transport and capacitation of sperm through the female genital tract. The CM undergoes modifications that make it have different biophysical and biochemical characteristics throughout the cycle, becoming an important element for the identification of ovulation. Since CM is rich in secreted proteins, it may represent moreover a source of putative biomarkers for female reproductive tract diseases. This review is an attempt to collect relevant knowledge about the physicochemical properties and functions of the cervical mucus, including its important role as a clinical marker of female fertility, and draws attention to CM as a source of potential proteomic biomarkers...
April 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29666788/plausibility-of-menstrual-cycle-apps-claiming-to-support-conception
#11
Alexander Freis, Tanja Freundl-Schütt, Lisa-Maria Wallwiener, Sigfried Baur, Thomas Strowitzki, Günter Freundl, Petra Frank-Herrmann
The interval of peak fertility during the menstrual cycle is of limited duration, and the day of ovulation varies, even in women with fairly regular cycles. Therefore, menstrual cycle apps identifying the "fertile window" for women trying to conceive must be quite precise. A deviation of a few days may lead the couple to focus on less- or non-fertile days for sexual intercourse and thus may be worse than random intercourse. The aim of the present investigation was to develop a scoring system for rating available apps for determining the fertile window and secondarily pilot test 12 apps currently available in both German and English (consisting of 6 calendar-based apps: Clue Menstruations- und Zykluskalender, Flo Menstruationskalender, Maya-Mein Periodentracker, Menstruationskalender Pro, Period Tracker Deluxe, and WomanLog-Pro-Kalender; 2 calculothermal apps: Ovy and Natural Cycles; and 4 symptothermal apps: myNFP, Lady Cycle, Lily, and OvuView)...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29662904/identification-of-differentially-expressed-genes-in-porcine-ovaries-at-proestrus-and-estrus-stages-using-rna-seq-technique
#12
Songbai Yang, Xiaolong Zhou, Yue Pei, Han Wang, Ke He, Ayong Zhao
Estrus is an important factor for the fecundity of sows, and it is involved in ovulation and hormone secretion in ovaries. To better understand the molecular mechanisms of porcine estrus, the expression patterns of ovarian mRNA at proestrus and estrus stages were analyzed using RNA sequencing technology. A total of 2,167 differentially expressed genes (DEGs) were identified ( P ≤ 0.05, |log2   Ratio| ≥ 1), of which 784 were upregulated and 1,383 were downregulated in the estrus compared with the proestrus group...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29662710/natural-cycle-versus-artificial-cycle-in-frozen-thawed-embryo-transfer-a-randomized-prospective-trial
#13
Marzieh Agha-Hosseini, Leila Hashemi, Ashraf Aleyasin, Marzieh Ghasemi, Fatemeh Sarvi, Maryam Shabani Nashtaei, Mahshad Khodarahmian
Objective: To investigate whether there was a difference in pregnancy outcomes between modified natural cycle frozen-thawed embryo transfer (NC-FET) cycles and artificial cycles (AC)-FET in women who all had regular menstrual cycles. Materials and Methods: One hundred seventy patients who met the inclusion criteria and had at least two cryopreserved embryos were included in a prospective randomized controlled trial. Eighty-five patients were randomized based on Bernoulli distribution into the following two groups: 1) Modified NC-FET using human chorionic gonadotropin for ovulation induction and 2) AC-FET, in which endometrial timing was programmed with estrogen and progesterone...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29661236/clinical-analysis-of-50-patients-with-heterotopic-pregnancy-after-ovulation-induction-or-embryo-transfer
#14
Zaigui Wu, Xinmei Zhang, Ping Xu, Xiufeng Huang
OBJECTIVES: The purpose of this study was to evaluate the clinical characteristics, prenatal diagnosis, and management of patients with heterotopic pregnancy after ovulation induction or embryo transfer. METHODS: This was a retrospective study of fifty cases with heterotopic pregnancy, in which the fertilization way, type and number of embryo transferred, gestational age, clinical presentation and outcome of intrauterine, ultrasound presentation and site of ectopic pregnancy, bilateral fallopian tube and treatment were evaluated...
April 16, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29661099/mir-125b-contributes-to-ovarian-granulosa-cell-apoptosis-through-targeting-bmpr1b-a-major-gene-for-sheep-prolificacy
#15
Yilong Yao, Anwaier Reheman, Yefei Xu, Qifa Li
Bone morphogenetic protein receptor 1B (BMPR1B) is a major gene for ovine ovulation rate and litter size, which plays a crucial role in follicle development. However, its role and regulation in the ovine granulosa cells (GCs) are unclear. Here, we showed that silencing of BMPR1B enhanced cell apoptosis, whereas overexpression of BMPR1B inhibited cell apoptosis in the ovine GCs. Luciferase reporter assays revealed that BMPR1B is a target of miR-125b, and miR-125b reduced BMPR1B messenger RNA and protein levels in the ovine GCs by directly binding to the 3' untranslated region of the ovine BMPR1B gene...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29659847/follicle-growth-and-endocrine-dynamics-in-women-with-spontaneous-luteinized-unruptured-follicles-versus-ovulation
#16
S T Bashir, A R Baerwald, M O Gastal, R A Pierson, E L Gastal
STUDY QUESTION: Do growth patterns and endocrine profiles differ between ovulatory follicles (OvFs) and luteinized unruptured follicles (LUFs) in women? SUMMARY ANSWER: Growth rates, diameters and associated endocrine profiles differed between OvFs and LUFs in unstimulated cycles. WHAT IS KNOWN ALREADY: Two-three waves of antral follicles develop during the menstrual cycle in ovulatory women of reproductive age, with the second or third wave terminating in ovulation...
April 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659700/sex-steroids-drive-the-remodeling-of-oviductal-extracellular-matrix-in-cattle
#17
Angela Maria Gonella-Diaza, Fernando Silveira Mesquita, Everton Lopes, Kauê Ribeiro da Silva, Bruno Cogliati, Ricardo De Francisco Strefezzi, Mario Binelli
The extracellular matrix (ECM) is a group of molecules that offer structural and biochemical support to cells and interact with them to regulate their function. Also, growth factors (GFs) stored in the ECM can be locally released during the ECM remodeling process. Here, we hypothesize that the balance between ECM components and remodelers is regulated according to the ovarian steroid milieu to which the oviduct is exposed during the periovulatory period. Follicular growth was manipulated to generate cows that ovulated small follicles (SF-SCL; n = 20) or large follicles (LF-LCL; n = 21) and possess corresponding Estradiol (E2) and Progesterone (P4) plasmatic concentrations...
April 5, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29656770/assisted-reproduction-in-the-female-cat
#18
REVIEW
Aime K Johnson
Assisted reproduction in the queen can range from simple ovulation induction to more advanced techniques such as in vitro fertilization. This article describes techniques available and the success associated with each.
April 12, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29656519/character-evolution-and-missing-morphological-data-across-asteridae
#19
Gregory W Stull, Melanie Schori, Douglas E Soltis, Pamela S Soltis
PREMISE OF THE STUDY: Our current understanding of flowering plant phylogeny provides an excellent framework for exploring various aspects of character evolution through comparative analyses. However, attempts to synthesize this phylogenetic framework with extensive morphological data sets have been surprisingly rare. Here, we explore character evolution in Asteridae (asterids), a major angiosperm clade, using an extensive morphological data set and a well-resolved phylogeny. METHODS: We scored 15 phenotypic characters (spanning chemistry, vegetative anatomy, and floral, fruit, and seed features) across 248 species for ancestral state reconstruction using a phylogenetic framework based on 73 plastid genes and the same 248 species...
April 14, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29656071/-natural-cycle-for-frozen-thawed-embryo-transfer-spontaneous-ovulation-or-triggering-by-hcg
#20
S Huberlant, M Vaast, T Anahory, M L Tailland, N Rougier, N Ranisavljevic, S Hamamah
OBJECTIVE: To compare frozen-thawed embryo transfer (FET) outcomes in natural cycles according to ovulation induction: spontaneous versus recombinant human chorionic gonadotrophin (r-hCG) triggering. METHODS: This retrospective study included all patients monitored for natural cycle FET during one year. When serial monitoring were performed until spontaneous LH rise, patients were included in group A (n=38) whereas those receiving r-hCG for ovulation triggering formed group B (n=43)...
April 11, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
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