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https://www.readbyqxmd.com/read/28324064/bmp7-induces-uterine-receptivity-and-blastocyst-attachment
#1
Diana Monsivais, Caterina Clementi, Jia Peng, Paul T Fullerton, Renata Prunskaite-Hyyryläinen, Seppo Vainio, Martin M Matzuk
In women, the window of implantation is limited to a brief two- to three- day period characterized by optimal levels of circulating ovarian hormones and a receptive endometrium. Although the window of implantation is assumed to occur 8-10 days after ovulation in women, molecular markers of endometrial receptivity are necessary to determine optimal timing prior to embryo transfer. Previous studies showed that members of the bone morphogenetic protein (BMP) family are expressed in the uterus necessary for female fertility; however, the role of BMP7 during implantation and in late gestation is not known...
January 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323945/coordinated-regulation-among-progesterone-prostaglandins-and-egf-like-factors-in-human-ovulatory-follicles
#2
Yohan Choi, Kalin Wilson, Patrick R Hannon, Katherine L Rosewell, Mats Brännström, James W Akin, Thomas E Curry, Misung Jo
CONTEXT: In animal models, the LH surge increases progesterone (P4)/its receptor (PGR), prostaglandins (PTGs), and epidermal growth factor (EGF)-like factors that play essential roles in ovulation. However, little is known about the expression, regulation, and function of these key ovulatory mediators in humans. OBJECTIVES: To determine when and how these key ovulatory mediators are induced after the luteinizing hormone surge in human ovaries. DESIGN AND PARTICIPANTS: Timed periovulatory follicles were obtained from cycling women...
March 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323862/is-floral-structure-a-reliable-indicator-of-breeding-system-in-the-brassicaceae
#3
Phillip A Salisbury, Yvonne J Fripp, Allison M Gurung, Warren M Williams
This study investigated the usefulness of floral characters as a potential indicator of breeding system in the Brassicaceae. Initially, pod set, seed set and pollen tube growth experiments were carried out to confirm the breeding systems of 53 lines representing 25 different cultivated and weedy species from the Brassicaceae. The results of the pod set tests clearly differentiated between self-compatible and self-incompatible species. Floral characters were then evaluated on one or more lines of each of the 25 species...
2017: PloS One
https://www.readbyqxmd.com/read/28319576/microscopic-heterotopic-extraovarian-sex-cord-stromal-proliferations-expanding-the-histologic-spectrum
#4
Aisling Longworth, Raji Ganesan, Adrian K H Yoong, Lynn Hirschowitz
Microscopic, heterotopic extraovarian sex cord-stromal proliferations have only recently been reported in the literature. We describe the largest series to date, of 30 cases of microscopic, incidentally detected, heterotopic extraovarian sex cord-stromal proliferation, in women aged 25-79 yr who had undergone surgery for a range of benign and malignant gynecologic conditions. In 14 patients the foci of proliferation comprised ovarian cortical stroma, in some cases with an ovarian fibroma-like appearance. Ten cases of adenofibroma and cystadenofibroma were also identified, including 1 Brenner adenofibroma; 2 cases comprised both ovarian cortical stroma and serous cystadenofibroma; 4 cases showed sex cord proliferation resembling microscopic adult granulosa cell tumors...
March 17, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28317066/er%C3%AE-and-gnrh-co-localize-in-the-hypothalamic-neurons-of-the-south-american-plains-vizcacha-lagostomus-maximus-rodentia-caviomorpha
#5
Pablo Ignacio Felipe Inserra, Santiago Elías Charif, Noelia Paula Di Giorgio, Lucía Saucedo, Alejandro Raúl Schmidt, Nicolas Fraunhoffer, Julia Halperin, María Constanza Gariboldi, Noelia Paola Leopardo, Victoria Lux-Lantos, Candela Rocío Gonzalez, Alfredo Daniel Vitullo, Verónica Berta Dorfman
Gonadotropin-releasing hormone (GnRH) is the key regulator of the hypothalamic-pituitary-gonadal axis. Estradiol (E2) affects GnRH synthesis and delivery. Hypothalamic estrogen receptors (ER) modulate GnRH expression acting as transcription factors. The South American plains vizcacha, Lagostomus maximus, is able to ovulate up to 800 oocytes per reproductive cycle, and shows continuous folliculogenesis with pre-ovulatory follicle formation and an ovulatory event at mid-gestation. The aim of this work was to analyze the hypothalamic expression of ER in the vizcacha at different gestational time-points, and its relationship with GnRH expression, serum luteinizing hormone (LH) and E2...
March 19, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28315411/extrauterine-choriocarcinoma-in-the-fallopian-tube-following-infertility-treatment-implications-for-the-management-of-early-detected-ectopic-pregnancies
#6
Seung Chik Jwa, Shigeru Kamiyama, Hisako Takayama, Yoshimitsu Tokunaga, Tetsuro Sakumoto, Masahiro Higashi
Extrauterine choriocarcinoma in the fallopian tube is highly rare and is often diagnosed and treated as an ectopic tubal pregnancy. A 34-year old woman who initially became pregnant after infertility treatment using ovulation induction with clomiphene citrate and intrauterine insemination was later diagnosed as having an extrauterine choriocarcinoma in the left fallopian tube. Because of a suspicion of left ectopic tubal pregnancy by ultrasonographic findings and high levels of beta human chorionic gonadotropin (β-hCG; 7054...
March 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28306560/growth-hormone-in-ivf-cycles-any-hope
#7
Roger J Hart, Luk Rombauts, Robert J Norman
PURPOSE OF REVIEW: Growth hormone (GH) has been used as an adjunct in ovulation induction and IVF for 25 years, particularly as an adjunct to ovarian stimulation for women who had a previous poor response to stimulation in an IVF cycle. It does not have US Food and Drug Administration approval for this use. Unfortunately, due to the problems inherent with recruiting women who have undergone unsuccessful IVF treatment cycles and their inevitable low live birth rate per initiated cycle, many studies performed to date have been underpowered...
March 16, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28303993/predictive-factors-for-pregnancy-outcome-following-controlled-ovarian-stimulation-and-intrauterine-insemination
#8
Goncayetkin Yildirim, Lale Susan Turkgeldi, Nadiye Koroglu
OBJECTIVE: To establish predictive factors for positive pregnancy outcome in cases of controlled ovarian stimulation and intrauterine insemination. METHODS: The retrospective study was conducted at Kanuni Sultan Suleyman Training and Research Hospital and comprised subjects having undergone ovulation induction cycles and intrauterine insemination between June 2010 and June 2015. Data was analysed in terms of various parameters affecting clinical pregnancy rates...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28303339/evidence-for-post-zygotic-self-incompatibility-in-handroanthus-impetiginosus-bignoniaceae
#9
Nelson Sabino Bittencourt Júnior
Late-acting self-incompatibility (LSI) has been defined as a genetically controlled self-sterility mechanism that prevents seed set by selfing, despite normal pollen tube growth and ovule penetration in self-pollinated pistils. In species of the Bignoniaceae with LSI, such as Handroanthus impetiginosus, the selfed pistils are characterized by a marked delay in ovule penetration, fertilization, and endosperm initiation, followed by uniform pistil abscission. This highlights the contentious possibility of a post-zygotic self-incompatibility system...
March 16, 2017: Plant Reproduction
https://www.readbyqxmd.com/read/28302175/prolonged-hypothyroidism-severely-reduces-ovarian-follicular-reserve-in-adult-rats
#10
Li Meng, Eddy Rijntjes, Hans J M Swarts, Jaap Keijer, Katja J Teerds
BACKGROUND: There is substantial evidence both in humans and in animals that a prolonged reduction in plasma thyroid hormone concentration leads to reproductive problems, including disturbed folliculogenesis, impaired ovulation and fertilization rates, miscarriage and pregnancy complications. The objective of the present study is to examine the consequences of chronic hypothyroidism, induced in adulthood, for the size of the ovarian follicle pool. In order to investigate this, adult female rats were provided either a control or an iodide deficient diet in combination with perchlorate supplementation to inhibit iodide uptake by the thyroid...
March 16, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28297660/progesterone-prevents-high-grade-serous-ovarian-cancer-by-inducing-necroptosis-of-p53-defective-fallopian-tube-epithelial-cells
#11
Na-Yiyuan Wu, Hsuan-Shun Huang, Tung Hui Chao, Hsien Ming Chou, Chao Fang, Chong-Zhen Qin, Chueh-Yu Lin, Tang-Yuan Chu, Hong Hao Zhou
High-grade serous ovarian carcinoma (HGSOC) originates mainly from the fallopian tube (FT) epithelium and always carries early TP53 mutations. We previously reported that tumors initiate in the FT fimbria epithelium because of apoptotic failure and the expansion of cells with DNA double-strand breaks (DSB) caused by bathing of the FT epithelial cells in reactive oxygen species (ROSs) and hemoglobin-rich follicular fluid (FF) after ovulation. Because ovulation is frequent and HGSOC is rare, we hypothesized that luteal-phase progesterone (P4) could eliminate p53-defective FT cells...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28295469/assessing-new-peptides-that-may-be-involved-in-the-physiological-regulation-of-the-gonadal-axis-in-humans-gonadotropin-inhibitory-hormone
#12
Peter Y Liu
The hypothalamo-pituitary-testicular (HPT) and hypothalamo-pituitary-ovarian (HPO) axes are integrated networks that regulate androgenization or estrogenization (including embryonic, infantile, pubertal and adult sexual maturation), male or female sexual behavior, and spermatogenesis or ovulation, respectively. Dysregulation of the HPT axis, for example, results in pubertal delay, eunuchism, impaired spermatogenesis, and reduced systemic androgen exposure; and may also contribute to some of the features of male aging, impair recovery from protracted critical illness, and induce visceral adiposity, sarcopenia, osteopenia, and insulin resistance...
March 13, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28288197/dog-cloning-with-in-vivo-matured-oocytes-obtained-using-electric-chemiluminescence-immunoassay-predicted-ovulation-method
#13
Seunghoon Lee, Minghui Zhao, Jingu No, Yoonseok Nam, Gi-Sun Im, Tai-Young Hur
Radioactive immunoassay (RIA) is a traditional serum hormone assay method, but the application of the method in reproductive studies is limited by the associated radioactivity. The aim of present study was to evaluate the reliability of RIA and to compare its canine serum progesterone concentration determination accuracy to that of the electric chemiluminescence immunoassay (ECLI). In vivo matured oocytes were utilized for canine somatic cell nuclear transfer (SCNT), and serum progesterone levels were assessed to accurately determine ovulation and oocyte maturation...
2017: PloS One
https://www.readbyqxmd.com/read/28285882/effect-of-altering-the-intervals-between-consecutive-superovulatory-doses-of-porcine-follicle-stimulating-hormone-on-ovarian-responses-and-embryo-yields-in-anestrous-ewes
#14
P M Bartlewski, M Murawski, T Schwarz, M E F Oliveira
The effect of varying intervals between successive gonadotropin injections on the superovulatory outcomes in anestrous Rideau Arcott ewes superstimulated for ovarian follicular development with multiple doses of porcine FSH (pFSH) was evaluated in a single study. Twenty-five animals received six (1×2.5ml and 5×1.25ml) injections of Folltropin(®)-V given at 0800 and 1600h or at 0800 and 2000h in Group 1 (n=9) or Group 2 (n=16), respectively. An i.m. injection of 500 IU of equine chorionic gonadotropin (eCG; Folligon(®)) was given concurrently with the first pFSH dose...
March 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28285615/consensus-on-the-integrated-traditional-chinese-and-western-medicine-criteria-of-diagnostic-classification-in-polycystic-ovary-syndrome-draft
#15
Jin Yu, Chao-Qin Yu, Qi Cao, Li Wang, Wen-Jun Wang, Li-Rong Zhou, Jing Li, Qiao-Hong Qian
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder of women, with complex pathogenesis and heterogeneous manifestations. Professor Jin Yu recently wrote an article entitled "Proposal of Diagnosis and Diagnostic Classification of PCOS in Integrated Traditional Chinese and Western Medicine."From this, the Obstetrics and Gynecology branches of the Chinese Association of Integrative Medicine and the China Association of Chinese Medicine collaborated with the Gynecology branch of the Chinese Association for Research and Advancement of Chinese Medicine to draft a report on the consensus of criteria for the diagnosis and classification of PCOS in integrated traditional Chinese and Western medicine...
March 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28285614/effectiveness-of-co-treatment-with-traditional-chinese-medicine-and-letrozole-for-polycystic-ovary-syndrome-a-meta-analysis
#16
Qian-Wen Ma, Yong Tan
BACKGROUND: Polycystic ovary syndrome (PCOS) is an endocrine disease that affects gynecological health. Treatment of PCOS remains a big challenge for clinicians. OBJECTIVE: This meta-analysis was developed to compare the efficacy of co-treatment with traditional Chinese medicine (TCM) and letrozole against letrozole monotherapy in the treatment of PCOS. SEARCH STRATEGY: Randomized controlled trials (RCTs) were electronically retrieved from PubMed, Cochrane Library, China Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang Data; related papers that were not available electronically were manually checked...
March 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28283264/uterine-contractility-and-elastography-as-prognostic-factors%C3%A2-for-pregnancy-after-intrauterine-insemination
#17
Nelly Swierkowski-Blanchard, Florence Boitrelle, Laura Alter, Jacqueline Selva, Thibaud Quibel, Antoine Torre
OBJECTIVE: To determine the impact of the frequency and intensity of uterine contractions (UCs) at the time of IUI on subsequent fertility. DESIGN: Observational pilot study. SETTING: University hospital. PATIENT(S): One hundred volunteer women scheduled for IUI between April 2011 and July 2013, in whom UCs were assessed during the ultrasound before IUI. INTERVENTION(S): A two-dimensional sagittal uterus elastography was recorded for 5 minutes...
March 7, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28282768/potential-autofertility-in-true-hermaphrodites
#18
Zeki Bayraktar
This article examines the studies on the pregnancies of true hermaphrodites and self-fertilization in hermaphrodite mammals that have been published in the last 40 years. The number of hermaphrodite pregnants reported in the literature since 1975 was 14, the number of pregnancies was 26 and the number of healthy born babies was 20. All of the babies that were born were male. The pregnancy developed following gonadectomy in seven cases (nine pregnancies). In some cases, either gonadectomy was not performed at all or it was performed after pregnancy (eight cases, 17 pregnancies)...
February 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28280800/clomiphene-citrate-versus-letrozole-with-gonadotropins-in-intrauterine-insemination-cycles-a-randomized-trial
#19
Leila Pourali, Sedigheh Ayati, Shirin Tavakolizadeh, Hourieh Soleimani, Fatemeh Teimouri Sani
BACKGROUND: Clomiphene citrate is one of the effective drugs for infertility treatment due to oligo-ovulation or anovulation. Intrauterine insemination (IUI) is one of more adherent methods for treatment of infertile cases which is followed by controlled ovarian hyperstimulation (COH). OBJECTIVE: the aim of this study was to evaluate Clomiphene citrate versus letrozole with gonadotropins in IUI cycles. MATERIALS AND METHODS: In this prospective randomized trial, 180 infertile women who were referred to Milad Hospital were selected...
January 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28277799/missed-pills-frequency-reasons-consequences-and-solutions
#20
Nathalie Chabbert-Buffet, Christian Jamin, Iñaki Lete, Paloma Lobo, Rossella E Nappi, Axelle Pintiaux, Günther Häusler, Christian Fiala
OBJECTIVES: Oral hormonal contraception is an effective contraceptive method as long as regular daily intake is maintained. However, a daily routine is a constraint for many women and can lead to missed pills, pill discontinuation and/or unintended pregnancy. This article describes the frequency of inconsistent use, the consequences, the risk factors and the possible solutions. METHODS: The article comprises a narrative review of the literature. RESULTS: Forgetting one to three pills per cycle is a frequent problem among 15-51% of users, generally adolescents...
March 9, 2017: European Journal of Contraception & Reproductive Health Care
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