Linhai Wang, Shu Tian, Sisi Ruan, Jingjing Wei, Sijia Wei, Weiwei Chen, Hangcui Hu, Weiwei Qin, Yan Li, Hang Yuan, Jian Mao, Yan Xu, Jianping Xie
Parkinson's disease (PD) is a prevalent progressive and multifactorial neurodegenerative disorder. Cordycepin is known to exhibit antitumor, anti-inflammatory, antioxidative stress, and neuroprotective effects; however, few studies have explored the neuroprotective mechanism of cordycepin in PD. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we investigated the impact of cordycepin on PD and its underlying molecular mechanisms. The findings indicated that cordycepin significantly mitigated MPTP-induced motor dysfunction and neuroapoptosis, diminished the loss of dopaminergic neurons in the striatum-substantia nigra pathway, elevated striatal monoamine levels and its metabolites, and increased the levels of striatal monoamine and its metabolites, and inhibited the polarization of microglia and the expression of pro-inflammatory factors...
March 11, 2024: Free Radical Biology & Medicine