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https://www.readbyqxmd.com/read/29786731/regioselective-and-diastereoselective-synthesis-of-two-functionalized-1-5-methanoindeno-1-2-d-azocines-via-a-three-component-reaction
#1
Jun Cao, Jing Sun, Chao-Guo Yan
The morpholine promoted three-component reaction of N-alkylpiperidinone, indane-1,3-dione and 2-arylideneindane-1,3-dione in ethanol at room temperature resulted in the (1H-1,5-methanoindeno[1,2-d]azocin-12-ylidene)-1H-indene-1,3(2H)-dione derivatives in good yields and with exo-configuration. Under similar conditions, the reaction of N-alkylpiperidinone with 2-arylideneindane-1,3-dione afforded 7H-1,5-methanoindeno[1,2-d]azocine-7,12-diones with endo-configuration. The domino reaction is believed to proceed with domino Knoevenagel condensation, Michael addition and aldol condensation reaction...
May 22, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29785268/impact-of-fullerene-derivative-isomeric-purity-on-the-performance-of-inverted-planar-perovskite-solar-cells
#2
Edison Castro, Gerardo Zavala, Sairaman Seetharaman, Francis D'Souza, Luis Echegoyen
The effect of utilizing a pure cis -α-dimethoxy carbonyl fulleropyrrolidine C70 (DMEC70 ) isomer as the electron transporting material (ETM) in inverted perovskite solar cells (PSCs) was evaluated. The as-prepared C70 mono-adduct products are mixtures of regioisomers and the interest was to evaluate them independently as ETMs. Three different cis -DMEC70 isomers (α, β- endo and β- exo ) (mix-DMEC70 ) were synthesized and purified by HPLC. It was found that PSCs based on the pure α-DMEC70 exhibit a substantially enhanced maximum power conversion efficiency (PCE) of 18...
September 28, 2017: Journal of Materials Chemistry. A, Materials for Energy and Sustainability
https://www.readbyqxmd.com/read/29784380/fluorescence-activation-imaging-of-localization-distribution-and-level-of-mirna-in-various-organelles-inside-cells
#3
Chuanli Wu, Xiaoyan Liu, Yiyi Zheng, Wenjing He, Guancao Yang, Ping Wu, Chenxin Cai
This work reports an approach for imaging the localization, distribution, and level of miRNA in different organelles based on an activated fluorescence signal triggered by an alteration of the specific binding-induced conformation of the designed activatable probe. We selected miR-150 as an miRNA example to image its localization, distribution, and level in human cervical cancer cells (HeLa cells). The results indicate that miR-150 is localized and distributed in different subcellular organelles (mainly in mitochondria and lysosomes) and that its levels (actually its concentrations) in lysosomes are higher than those in mitochondria in both HeLa and MCF-7 cells...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783031/a-unique-all-payer-rate-setting-system-controls-the-cost-but-not-the-racial-disparity-in-lower-extremity-revascularization-procedures
#4
Besma Nejim, Robert J Beaulieu, Husain Alshaikh, Mohammed Hamouda, Joseph Canner, Mahmoud B Malas
BACKGROUND: Patients with peripheral arterial disease (PAD) often have high comorbidity burden that may complicate post-interventional course and drive increased healthcare expenditures. Racial disparity had been observed in lower extremity revascularization (LER) patterns and outcomes. In 2014, Maryland adopted an all-payer rate setting system to limit the rising hospitalization costs. This resulted in an aggregate payment system in which hospital compensation takes place as an overall per capita expenditure for hospital services...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29782844/evaluation-of-the-serum-ionic-fluoride-concentration-as-a-biomarker-of-bone-metabolism-post-spinal-fusion-surgery
#5
Ryosuke Oikawa, Yuji Fujita, Hideki Murakami, Hirooki Endo, Daisuke Yamabe, Yusuke Chiba, Yuichiro Abe, Minoru Doita
BACKGROUND: Bone union after spinal fusion surgery with instrumentation has been determined only with imaging studies. We evaluated the usefulness of the serum ionic fluoride (SIF) concentration as a biomarker of the bone union status. METHODS: We enrolled 25 patients who underwent spinal surgery in our institution, and we divided patients into three groups with and without instrumentation (G1, G2, and G3). We collected the fasting serum level preoperatively and on day 1 (D1), week 1 (D7), week 2 (D14), month 1 (D30), month 3 (D90), and month 6 (D180) postoperatively, and measured SIF concentrations using the flow injection method with an ion-selective electrode...
May 18, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29780981/detailed-investigation-on-how-the-protein-corona-modulates-the-physicochemical-properties-and-gene-delivery-of-polyethylenimine-pei-polyplexes
#6
Dingcheng Zhu, Huijie Yan, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Raimo Hartmann, Wolfgang J Parak, Neus Feliu, Youqing Shen
Given the various cationic polymers developed as non-viral gene delivery vectors, polyethylenimine (PEI) has been/is frequently used in in vitro transfection. However, the primary drawback limiting its in vivo applications is the sharp decrease in transfection efficiency in the presence of serum. Here, we investigated the influences of serum proteins or bovine serum albumin (BSA) on the physicochemical properties of PEI/DNA complexes (polyplexes), including hydrodynamic diameters and agglomeration behavior, zeta potentials, morphologies, and sensitivity to the presence of salt...
May 21, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29780715/endovascular-treatment-of-acute-type-a-aortic-dissection-the-endo-bentall-approach
#7
Maximilian Kreibich, Bartosz Rylski, Stoyan Kondov, Julia Morlock, Johannes Scheumann, Fabian A Kari, Holger Schröfel, Matthias Siepe, Friedhelm Beyersdorf, Martin Czerny
Outcome after classical surgical repair of acute Type A aortic dissection has steadily improved over the years and several modifications in cannulation and perfusion added to this achievement. However, subgroups remain where results of classical surgical repair still have room for improvement, particularly patients with severe preoperative malperfusion as well as elderly patients with a limited physiological reserve. So far, only small case series or case reports have been published on the endovascular treatment of dissected ascending aortas...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29780145/reversible-cognitive-dysfunction-in-elderly-onset-systemic-lupus-erythematosus-successfully-treated-with-aggressive-immunosuppressive-therapy
#8
Yuya Fujita, Shoichi Fukui, Midori Ishida, Yushiro Endo, Sosuke Tsuji, Ayuko Takatani, Takashi Igawa, Toshimasa Shimizu, Masataka Umeda, Remi Sumiyoshi, Ayako Nishino, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Atsushi Kawakami
A 70-year-old Japanese woman presented to our hospital with gait disturbance and cognitive dysfunction. Since she had arthritis, leukocytopenia, thrombocytopenia, hypocomplementemia, and anti-nuclear and anti-double-stranded DNA antibodies, she was diagnosed with systemic lupus erythematosus (SLE). T2-weighted magnetic resonance imaging revealed bilateral hyperintensities in the putamen. Based on her cognitive impairment, muscle rigidity, and high levels of interleukin-6 in the cerebrospinal fluid, we believed she had developed a complication of a neuropsychiatric disease and administered corticosteroids and intravenous cyclophosphamide therapy...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29780143/improvement-of-the-left-ventricular-function-after-tricuspid-valve-plasty-for-traumatic-tricuspid-regurgitation
#9
Taiji Okada, Kaori Mogi, Akihiro Endo, Hiroyuki Yoshitomi, Teiji Oda, Kazuaki Tanabe
Traumatic tricuspid regurgitation (TR) is a rare cardiovascular complication in chest trauma. Changes in the left ventricle (LV) function after operation are unclear. A 61-year-old woman who had been involved in a traffic accident 1 month earlier presented with exertional dyspnea. Transthoracic echocardiography (TTE) showed severe tricuspid regurgitation (TR) accompanied by LV dysfunction due to anterior leaflet prolapse with papillary muscle rupture. After tricuspid plasty, the LV function improved, as evidenced by TTE and speckle tracking echocardiography...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29780051/-recent-review-articles-in-radiological-physics-and-technology
#10
Shigeru Sanada, Rie Tanaka, Yoshie Kodera, Junji Shiraishi, Fujio Araki, Kosuke Matsubara, Masahiro Endo
No abstract text is available yet for this article.
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29778502/hematopoietic-stem-cell-transplantation-for-progressive-combined-immunodeficiency-and-lymphoproliferation-in-activated-pi3k-delta-syndrome-type-1
#11
Tsubasa Okano, Kohsuke Imai, Yuki Tsujita, Noriko Mitsuiki, Kenichi Yoshida, Chikako Kamae, Kenichi Honma, Kanako Mitsui-Sekinaka, Yujin Sekinaka, Tamaki Kato, Katsuyuki Hanabusa, Eri Endo, Takehiro Takashima, Haruka Hiroki, Tzu-Wen Yeh, Keisuke Tanaka, Masakazu Nagahori, Ikuya Tsuge, Yuki Bando, Fuminori Iwasaki, Yoshiaki Shikama, Masami Inoue, Tomiko Kimoto, Naohiko Moriguchi, Yuki Yuza, Takashi Kaneko, Kyoko Suzuki, Tomoyo Matsubara, Yoshihiro Maruo, Tomoaki Kunitsu, Tomoko Waragai, Hideki Sano, Yuko Hashimoto, Kazuhiro Tasaki, Osamu Suzuki, Toshihiko Shirakawa, Motohiro Kato, Toru Uchiyama, Masataka Ishimura, Tetsuzo Tauchi, Hiroshi Yagasaki, Shiann-Tarng Jou, Hsin-Hui Yu, Hirokazu Kanegane, Sven Kracker, Anne Durandy, Daiei Kojima, Hideki Muramatsu, Taizo Wada, Yuzaburo Inoue, Hidetoshi Takada, Seiji Kojima, Seishi Ogawa, Osamu Ohara, Shigeaki Nonoyama, Tomohiro Morio
BACKGROUND: Activated phosphatidylinositol-3-OH kinase-delta (PI3Kδ) syndrome type 1 (APDS1) is a recently described primary immunodeficiency syndrome characterized by recurrent respiratory infections, lymphoid hyperplasia, and herpesviridae infections due to germline gain-of-function mutations of PIK3CD. Hematopoietic stem cell transplantation (HSCT) may be considered to ameliorate progressive immunodeficiency and associated malignancy, but appropriate indications, method, and outcomes of HSCT for APDS1 remain undefined...
May 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29777191/eradication-of-hepatitis-c-virus-is-associated-with-the-attenuation-of-steatosis-as-evaluated-using-a-controlled-attenuation-parameter
#12
Kohei Shimizu, Yoko Soroida, Masaya Sato, Hiromi Hikita, Tamaki Kobayashi, Momoe Endo, Mamiko Sato, Hiroaki Gotoh, Tomomi Iwai, Ryosuke Tateishi, Kazuhiko Koike, Yutaka Yatomi, Hitoshi Ikeda
Chronic hepatitis C virus (HCV) infection was shown to cause hepatic steatosis or suppression of serum lipid levels. However, little is known about the changes in hepatic steatosis following HCV eradication. We aimed to evaluate this issue using the controlled attenuation parameter (CAP), which was recently shown to provide a standardized non-invasive measure of hepatic steatosis. We enrolled 70 patients with chronic HCV infections and steatosis (CAP of over 248 dB/m) who had achieved a sustained viral response at 12 weeks after discontinuation of antiviral treatment using direct-acting antivirals (DAA)...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29775719/the-characteristics-and-antioxidation-of-oudemansiella-radicata-selenium-polysaccharides-on-lipopolysaccharide-induced-endo-toxemic-mice
#13
Zheng Gao, Chen Zhang, Hui Liu, Yongfa Zhu, Zhenzhen Ren, Huijuan Jing, Shangshang Li, Jianjun Zhang, Xingtian Liu, Le Jia
The selenium polysaccharides (SPS) by Oudemansiella radicata were isolated, and two hydrolysates (enzymatic-SPS (ESPS) and acidic-SPS (ASPS)) were obtained by enzymolysis and acidolysis. The endo-toxemic-induced lung and kidney damages were successfully established by the lipopolysaccharides (LPS) injection (5 mg/kg/d). The in vivo mice experiments indicated that the ESPS showed superior antioxidant and protective effects against the LPS-toxicities by increasing the antioxidant activities, reducing lipid peroxidation, improving the inflammatory response and elevating the kidney and lung functions than SPS and ASPS...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775699/relationship-between-intraprostatic-urethral-sphincter-status-and-prostate-volume-as-revealed-by-magnetic-resonance-imaging
#14
Fumiyasu Endo, Kazuhiro Ohwaki, Masaki Shimbo, Kazunori Hattori
OBJECTIVES: To evaluate the relationship between the lengths of two regions of the intraprostatic urethral sphincter, the distal region (from the apex to the adenoma; AA) and the proximal region (from the adenoma to the verumontanum; AV) and prostate volume (PV) in patients with clinical benign prostate hyperplasia. METHODS: A total of 110 patients who underwent magnetic resonance imaging (MRI) prior to holmium laser enucleation of the prostate were enrolled. The lengths of two distinct intraprostatic urethral regions were measured on MRI, and we used multiple regression analysis to explore the association between these lengths and PV...
May 15, 2018: Urology
https://www.readbyqxmd.com/read/29774620/cellulose-degradation-in-gastrophysa-viridula-coleoptera-chrysomelidae-functional-characterization-of-two-cazymes-belonging-to-glycoside-hydrolase-family-45-reveals-a-novel-enzymatic-activity
#15
André Busch, Grit Kunert, Natalie Wielsch, Yannick Pauchet
Cellulose is a major component of the primary and secondary cell walls in plants. Cellulose is considered to be the most abundant biopolymer on Earth and represents a large potential source of metabolic energy. Yet, cellulose degradation is rare and mostly restricted to cellulolytic microorganisms. Recently, various metazoans, including leaf beetles, have been found to encode their own cellulases, giving them the ability to degrade cellulose independently of cellulolytic symbionts. Here, we analyzed the cellulosic capacity of the leaf beetle Gastrophysa viridula, which typically feeds on Rumex plants...
May 17, 2018: Insect Molecular Biology
https://www.readbyqxmd.com/read/29772482/baseline-serum-sitosterol-level-as-predictor-of-adverse-clinical-events-in-acute-coronary-syndrome-patients-with-dyslipidaemia-a-sub-analysis-of-hij-proper
#16
Junichi Yamaguchi, Erisa Kawada-Watanabe, Ryo Koyanagi, Hiroyuki Arashi, Haruki Sekiguchi, Koichi Nakao, Tetsuya Tobaru, Hiroyuki Tanaka, Toshiaki Oka, Yasuhiro Endo, Katsumi Saito, Tatsuro Uchida, Kunihiko Matsui, Hiroshi Ogawa, Nobuhisa Hagiwara
BACKGROUND AND AIMS: We aimed to examine the effect of serum sitosterol, a cholesterol absorption marker, on clinical outcomes in acute coronary syndrome patients with dyslipidaemia. METHODS: This is a sub-analysis of the HIJ-PROPER trial that assesses the effect of aggressive low-density lipoprotein cholesterol (LDL-C) lowering treatment with pitavastatin + ezetimibe in 1734 acute coronary syndrome (ACS) patients with dyslipidaemia. Patients were divided into two groups based on sitosterol level at enrolment (cut-off value was 2...
May 5, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29771521/gold-iii-catalyzed-selective-cyclization-of-alkynyl-quinazolinone-tethered-pyrroles-synthesis-of-fused-quinazolinone-scaffolds
#17
Lin-Su Wei, Guo-Xue He, Xiang-Fei Kong, Cheng-Xue Pan, Dong-Liang Mo, Gui-Fa Su
A series of 1,2- and 2,3-fused quinazolinones have been synthesized in good to excellent yields through gold-catalyzed selective hydroarylations of alkynyl quinazolinone-tethered pyrroles. The studies revealed that 1,2-fused quinazolinones were obtained through a 1,3-rearrangement and sequential 6-exo-trig cyclization of N1-alkynyl quinazolinone-tethered pyrroles while N3-alkynyl quinazolinone-tethered pyrroles went through 6-exo-dig or 7-endo-dig cyclizations directly to afford 2,3-fused quinazolinones. The fused quinazolinones could be prepared at gram scale in three steps from commercial ortho-aminobenzamide...
May 17, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29768818/hybrid-lead-halide-layered-perovskites-with-silsesquioxane-interlayers
#18
Sho Kataoka, Wako Kaburagi, Hiroyuki Mochizuki, Yoshihiro Kamimura, Kazuhiko Sato, Akira Endo
Hybrid organic-lead halide perovskites exhibit remarkable properties as semiconductors and light absorbers. Here, we report the formation of silsesquioxane-lead halide hybrid layered perovskites. We prepared silsesquioxane with a cubic cage-like structure and fabricated hybrid silsesquioxane-lead halide layered perovskites in a self-assembled manner. It is demonstrated that the silsesquioxane maintain their cage-like structure between lead halide perovskite layers. The silsesquioxane-lead halide perovskites also show excitonic absorption and emission in the visible light region similar to typical lead halide layered perovskites...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768722/genoprotective-effect-of-phyllanthus-orbicularis-extract-against-uva-uvb-and-solar-radiation
#19
Marioly Vernhes Tamayo, André Passaglia Schuch, Teiti Yagura, Luis Baly Gil, Carlos Frederico Martins Menck, Angel Sánchez-Lamar
One approach to protect the human skin against harmful effects of solar ultraviolet (UV) radiation is to use natural products as photoprotectors. In this work, the extract from specie Phyllanthus orbicularis K was evaluated as a protective agent against the photodamage by UVB, UVA artificial lamps and environmental sunlight exposure. The plasmid DNA solutions were exposed to radiations using the DNA-dosimeter system in presence of plant extract. The DNA repair enzymes, E. coli Formamidopyrimidine-DNA glycosylase (Fpg) and T4 bacteriophage endonuclease V (T4-endo V), were employed to discriminate oxidized DNA damage and cyclobutane pyrimidine dimers (CPD) respectively...
May 16, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29765811/comparative-genome-analysis-of-bacillus-velezensis-reveals-a-potential-for-degrading-lignocellulosic-biomass
#20
Long Chen, Wei Gu, Hai-Yan Xu, Gui-Lian Yang, Xiao-Feng Shan, Guang Chen, Yuan-Huan Kang, Chun-Feng Wang, Ai-Dong Qian
Genomes of 24 sequenced Bacillus velezensis strains were characterized to identity shared and unique genes of lignocellulolytic enzymes and predict potential to degrade lignocellulose. All 24 strains had genes that encoded lignocellulolytic enzymes, with potential to degrade cellulose and hemicelluloses. Several lignocellulosic genes related to cellulose degradation were universally present, including one GH5 (endo-1,4-β-glucanase), one GH30 (glucan endo-1,6-β-glucosidase), two GH4 (6-phospho-β-glucosidase, 6-phospho-α-glucosidase), one GH1 (6-phospho-β-galactosidase), one GH16 (β-glucanase) and three GH32 (two sucrose-6-phosphate hydrolase and levanase)...
May 2018: 3 Biotech
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