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https://www.readbyqxmd.com/read/29161043/gold-i-catalyzed-cyclization-carbonylation-cascade-reaction-of-1-6-diynes-an-access-to-%C3%AE-%C3%AE-unsaturated-ketones
#1
Ming Bao, Wei Lu, Yanping Cai, Lihua Qiu, Xinfang Xu
A gold-catalyzed cyclization/carbonylation cascade reaction of 1,6-diynes is reported. The reaction goes through 6-exo-dig and 6-endo-dig cyclizations in sequence, and followed by hydration to provide the β,γ-unsaturated ketones with moderate to high yields under mild reaction conditions. This is the first example of intercepting the postulated 1,3-oxazine vinylgold intermediate with another pendant alkyne, which not only verifies the proposed mechanism, but also provides the ketone products with cyclized 1,2,3,6-tetrahydropyridine or 3,6-dihydro-2H-pyran frameworks from corresponding diynes...
November 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29160879/molten-bacn2-for-the-sintering-and-crystal-growth-of-dielectric-oxynitride-perovskites-sr1-xbaxtao2n-x-0-04-0-23
#2
Akira Hosono, Yuji Masubuchi, Takashi Endo, Shinichi Kikkawa
Solid phase sintering of dielectric oxynitride perovskites above 1000 °C is accompanied by their decomposition. Post-ammonolysis is required to recover their stoichiometric nitrogen content and dielectric properties. In the present work, the oxynitride perovskite SrTaO2N was sintered with a BaCN2 flux at approximately 900 °C avoiding its thermal decomposition. The resulting solid product with a relative density of 68.9% showed relative dielectric constants in the range from 68 to 90 with loss values less than 0...
November 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29160405/dosimetry-in-cbct-with-different-protocols-emphasis-on-small-fovs-including-exams-for-tmj
#3
Helena Aguiar Ribeiro Nascimento, Marcos Ely Almeida Andrade, Marco Antonio Gomes Frazão, Eduarda Helena Leandro Nascimento, Flavia Maria Moraes Ramos-Perez, Deborah Queiroz Freitas
This study aimed to estimate the absorbed dose in cone beam computed tomography (CBCT) exams according to different exposure parameters and size and position of the field of view (FOV). In addition was compared the absorbed dose of two smaller FOV scans with that of a larger FOV scan for evaluation of temporomandibular joint (TMJ), as it is a bilateral structure. CBCT scans were obtained on OP300 Maxio unit varying scanning mode (standard, high and endo) as well as size (5x5, 6x8 and 8x15 cm) and positioning of FOV...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29158820/ph-sensitive-nano-complexes-overcome-drug-resistance-and-inhibit-metastasis-of-breast-cancer-by-silencing-akt-expression
#4
Jieying Yin, Tianqun Lang, Dongmei Cun, Zhong Zheng, Yan Huang, Qi Yin, Haijun Yu, Yaping Li
The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX and a siRNA, siAkt, directed at silencing the Akt expression. Methods: The pH-sensitive amphiphilic polymer, poly [(1,4-butanediol)-diacrylate-β-N, N-diisopropylethylenediamine]-polyethyleneimine (BDP) was synthesized...
2017: Theranostics
https://www.readbyqxmd.com/read/29158804/heparanase-contributes-to-trans-endothelial-migration-of-hepatocellular-carcinoma-cells
#5
Xiaopeng Chen, Wen Jiang, Chaofu Yue, Wenjun Zhang, Chaogang Tong, Dafei Dai, Bin Cheng, Chen Huang, Linming Lu
The overall outcome of patients with hepatocellular carcinoma (HCC) is still very poor due to its high metastasis and recurrence rate. During metastasis, trans-endothelial migration (TEM) of HCC cells is a key step. Heparanase (HPSE) is an endo-beta-glucuronidase and exerts prometastatic properties for normal and tumor-derived cells. However, it is remains unclear that HPSE contributes to TEM of HCC cells. In this study, human umbilical vein endothelial cells-C (HUVEC-C) was used to simulate vascular endothelial cells (VECs), and the HCCLM3 cells with high HPSE expression were chosen and used for in vitro TEM assay and in vivo experiment...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29158081/streptococcus-pyogenes-nuclease-a-spna-mediated-virulence-does-not-exclusively-depend-on-nuclease-activity
#6
Callum Chalmers, Adrina Hema J Khemlani, Chae Ryeong Sohn, Jacelyn Mei San Loh, Catherine Jia-Yun Tsai, Thomas Proft
BACKGROUND: Streptococcus pyogenes, or Group A Streptococcus (GAS), is a human pathogen that causes a wide range of diseases, including pharyngitis, necrotizing fasciitis and toxic shock syndrome. The bacterium produces a large arsenal of virulence factors, including the cell wall-anchored Streptococcus pyogenes nuclease A (SpnA), which facilitates immune evasion by degrading the DNA backbone of neutrophil extracellular traps. SpnA consists of a C-terminal endo/exonuclease domain and a N-terminal domain of unknown function...
November 13, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29155274/polysaccharides-from-the-south-african-medicinal-plant-artemisia-afra-structure-and-activity-studies
#7
Paula Marie Braünlich, Kari Tvete Inngjerdingen, Marit Inngjerdingen, Quinton Johnson, Berit Smestad Paulsen, Wilfred Mabusela
Artemisia afra (Jacq. Ex. Willd), is an indigenous plant in South Africa and other parts of the African continent, where it is used as traditional medicine mostly for respiratory conditions. The objective of this study was to investigate the structural features of the polysaccharides from the leaves of this plant, as well as the biological activities of the polysaccharide fractions against the complement assay. Leaves of Artemisia afra were extracted sequentially with organic solvents (dichloromethane and methanol), 50% aqueous ethanol, and water at 50 and 100°C respectively...
November 15, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29154782/neutrophil-depletion-protects-against-zomepirac-induced-acute-kidney-injury-in-mice
#8
Shohei Yamashita, Shingo Oda, Hideko Endo, Koichi Tsuneyama, Tsuyoshi Yokoi
Acyl glucuronide (AG) metabolites of carboxylic acid-containing drugs have been implicated in drug toxicity. Zomepirac (ZP) is a non-steroidal anti-inflammatory drug that was withdrawn from the market because of anaphylactic reactions and renal injury. We recently established a novel mouse model of ZP-induced kidney injury by increasing zomepirac acyl-glucuronide (ZP-AG) concentration via pretreatment with tri-O-tolyl phosphate, a nonselective esterase inhibitor, and l-buthionine-(S,R)-sulfoximine, a glutathione synthesis inhibitor...
November 14, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29154755/ribosome-surface-properties-may-impose-limits-on-the-nature-of-the-cytoplasmic-proteome
#9
Paul E Schavemaker, Wojciech M Śmigiel, Bert Poolman
Much of the molecular motion in the cytoplasm is diffusive, which possibly limits the tempo of processes. We studied the dependence of protein mobility on protein surface properties and ionic strength. We used surface-modified fluorescent proteins (FPs) and determined their translational diffusion coefficients (D) in the cytoplasm of Escherichia coli, Lactococcus lactis and Haloferax volcanii. We find that in E. coliD depends on the net charge and its distribution over the protein, with positive proteins diffusing up to 100-fold slower than negative ones...
November 20, 2017: ELife
https://www.readbyqxmd.com/read/29152357/crystal-structure-of-1r-5s-endo-8-methyl-8-azoniabi-cyclo-3-2-1-oct-3-yl-ammonium-aqua-tri-chlorido-nitratocopper-ii
#10
Sergey N Britvin, Andrey M Rumyantsev
The structure of a salt of diprotonated endo-3-amino-tropane crystallized with a copper(II) anionic cluster is reported, viz. (C8H18N2)[CuCl3(NO3)(H2O)]. Neither ion in the salt has been structurally characterized previously. In the crystal, the ions pack together to form a three-dimensional structure held together by a network of inter-molecular N-H⋯O, O-H⋯Cl and N-H⋯Cl hydrogen-bonding inter-actions. Selective crystallization of the title compound can be considered as a simple method for the separation of the exo and endo isomers of 3-amino-tropane...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29151532/association-of-admission-glucose-level-and-improvement-in-pulmonary-artery-pressure-in-patients-with-submassive-type-acute-pulmonary-embolism
#11
Masaomi Gohbara, Keigo Hayakawa, Azusa Hayakawa, Yusuke Akazawa, Yukihiro Yamaguchi, Shuta Furihata, Ai Kondo, Yusuke Fukushima, Sakie Tomari, Takayuki Mitsuhashi, Tsutomu Endo, Kazuo Kimura
Objective The admission glucose level is a predictor of mortality even in patients with acute pulmonary embolism (APE). However, whether or not the admission glucose level is associated with the severity of APE itself or the underlying disease of APE is unclear. Methods This study was a retrospective observational study. A pulmonary artery (PA) catheter was used to accurately evaluate the severity of APE. The percentage changes in the mean PA pressure (PAPm) upon placement and removal of the inferior vena cava filter (IVCF) were evaluated...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29151467/-preface-to-the-special-issue-on-3d-gel-dosimeters
#12
Masahiro Endo
No abstract text is available yet for this article.
2017: Japanese Journal of Medical Physics
https://www.readbyqxmd.com/read/29151129/one-novel-and-two-uncommon-mefv-mutations-in-japanese-patients-with-familial-mediterranean-fever-a-clinicogenetic-study
#13
Dai Kishida, Masahide Yazaki, Akinori Nakamura, Fumio Nomura, Takeshi Kondo, Takanori Uehara, Masatomi Ikusaka, Akira Ohya, Norihiko Watanabe, Ryuta Endo, Satoshi Kawaai, Yasuhiro Shimojima, Yoshiki Sekijima
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene and characterized by recurrent episodes of fever and polyserositis. To date, over 317 MEFV mutations have been reported, only nine of which account for almost all Japanese patients with FMF. Therefore, the prevalence of rare MEFV variants and their clinical characteristics remains unclear. This study identified MEFV mutations previously unreported in the Japanese population and described their clinical features...
November 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29150978/mice-lacking-a-functional-nmda-receptor-exhibit-social-subordination-in-a-group-housed-environment
#14
Waka Ujita, Ayako Kohyama-Koganeya, Nozomi Endo, Toki Saito, Hiroshi Oyama
Social dominance, in which an individual asserts control over others or benefits most after social conflict, has an influence on social behaviour. However, the mechanisms mediating social dominance remain unclear. Social dominance within social groups determines the distribution of rewards such as food and access to mating partners, which can act as reinforcers. In this study, we used the water competition test to determine whether mice were dominant or subordinate. We have previously reported that mice heterozygous for a missense mutation in Grin1 (Grin1(Rgsc174) ) showed altered social behaviour, with increased locomotor activity, novelty-seeking and anxiety...
November 18, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29150774/co-expression-of-exo-inulinase-and-endo-inulinase-genes-in-the-oleaginous-yeast-yarrowia-lipolytica-for-efficient-single-cell-oil-production-from-inulin
#15
Nianci Shi, Weian Mao, Xiaoxia He, Zhe Chi, Zhenming Chi, Guanglei Liu
Yarrowia lipolytica is a promising platform for the single cell oil (SCO) production. In this study, a transformant X+N8 in which exo- and endo-inulinase genes were co-expressed could produce an inulinase activity of 124.33 U/mL within 72 h. However, the inulinase activity of a transformant X2 carrying a single exo-inulinase gene was only 47.33 U/mL within 72 h. Moreover, the transformant X+N8 could accumulate 48.13% (w/w) SCO from inulin and the cell dry weight reached 13.63 g/L within 78 h, which were significantly higher than those of the transformant X2 (41...
November 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29150745/alignment-in-the-transverse-plane-but-not-sagittal-or-coronal-plane-affects-the-risk-of-recurrent-patella-dislocation
#16
Shigeru Takagi, Takashi Sato, Satoshi Watanabe, Osamu Tanifuji, Tomoharu Mochizuki, Go Omori, Naoto Endo
PURPOSE: Abnormalities of lower extremity alignment (LEA) in recurrent patella dislocation (RPD) have been studied mostly by two-dimensional (2D) procedures leaving three-dimensional (3D) factors unknown. This study aimed to three-dimensionally examine risk factors for RPD in lower extremity alignment under the weight-bearing conditions. METHODS: The alignment of 21 limbs in 15 RPD subjects was compared to the alignment of 24 limbs of 12 healthy young control subjects by an our previously reported 2D-3D image-matching technique...
November 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29149719/tissue-specific-bioaccumulation-of-long-chain-perfluorinated-carboxylic-acids-and-halogenated-methylbipyrroles-in-dall-s-porpoises-phocoenoides-dalli-and-harbor-porpoises-phocoena-phocoena-stranded-in-northern-japan
#17
Yukiko Fujii, Yoshihisa Kato, Kentarou Sakamoto, Takashi Matsuishi, Harada H Kouji, Akio Koizumi, Osamu Kimura, Tetsuya Endo, Koichi Haraguchi
This study investigated accumulation of perfluoroalkyl substances (PFASs), persistent organochlorines (OCs), and naturally produced halogenated compounds (NHCs), including brominated methylbipyrroles and methoxylated bromodiphenyl ethers, in liver, blood, and blubber from Dall's porpoises (Phocoenoides dalli) and harbor porpoises (Phocoena phocoena) stranded in Hokkaido, northern Japan. Profiles of the PFASs were dominated by perfluoroundecanoic acid and perfluorotridecanoic acid, both of which accounted for 70% of the total measured PFAS concentrations in both porpoise species...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29147917/recommendations-for-perioperative-management-of-lung-cancer-patients-with-comorbidities
#18
REVIEW
Hiroyoshi Tsubochi, Tomoki Shibano, Shunsuke Endo
OBJECTIVES: To improve surgical outcomes, clinicians must provide optimal perioperative care for comorbidities identified as significant factors in risk models for patients undergoing lung cancer surgery. METHODS: We reviewed trends in perioperative care for idiopathic pulmonary fibrosis, cardiovascular diseases, and end-stage renal diseases in patients undergoing lung cancer surgery, as large clinical databases indicate that these comorbidities are significant risk factors for lung cancer surgery...
November 16, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29147809/application-of-actuator-driven-pulsed-water-jet-for-coronary-artery-bypass-grafting-assessment-in-a-swine-model
#19
Tomoyuki Suzuki, Shunsuke Kawamoto, Atsuhiro Nakagawa, Toshiki Endo, Teiji Tominaga, Masatoshi Akiyama, Osamu Adachi, Kiichiro Kumagai, Yoshikatsu Saiki
Actuator-driven pulsed water-jet (ADPJ) dissection is an emerging surgical method for dissecting tissue without heat and mechanical injury to vessels. We elucidated the mechanical properties of the piezo ADPJ and evaluated its usefulness and safety in coronary artery bypass grafting procedures. The relationship between the input voltage (10-100 V) and peak pressure of the pulsed water jet was evaluated. The tissue strengths of swine internal thoracic and coronary arteries and the surrounding tissues were measured to assure tissue-selective dissection...
November 16, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29147531/catalysis-of-a-1-3-dipolar-reaction-by-distorted-dna-incorporating-a-heterobimetallic-platinum-ii-and-copper-ii-complex
#20
Iván Rivilla, Abel de Cózar, Thomas Schäfer, Frank J Hernandez, Alexander M Bittner, Aitziber Eleta-Lopez, Ali Aboudzadeh, José I Santos, José I Miranda, Fernando P Cossío
A novel catalytic system based on covalently modified DNA is described. This catalyst promotes 1,3-dipolar reactions between azomethine ylides and maleimides. The catalytic system is based on the distortion of the double helix of DNA by means of the formation of Pt(ii) adducts with guanine units. This distortion, similar to that generated in the interaction of DNA with platinum chemotherapeutic drugs, generates active sites that can accommodate N-metallated azomethine ylides. The proposed reaction mechanism, based on QM(DFT)/MM calculations, is compatible with thermally allowed concerted (but asynchronous) [π4s + π2s] mechanisms leading to the exclusive formation of racemic endo-cycloadducts...
October 1, 2017: Chemical Science
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