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https://www.readbyqxmd.com/read/28231574/biomarkers-in-allergic-airway-disease-simply-complex
#1
Adam M Chaker, Ulrich M Zissler, Martin Wagenmann, Carsten Schmidt-Weber
Clinical diagnoses of allergic airway disease need confirmation of a relevant sensitization to allergens. Serum-based component-resolved diagnosis has become increasingly popular and allows the precise assessment of specific IgE to molecular allergens. Molecular allergen diagnosis has improved our understanding of disease phenotypes in allergic patients, including cross-reactive patterns and food allergy. Beyond sensitization profiles, characterization of the (endo-)type and severity of a local allergic disease is useful for targeted therapy with biologics in advanced allergic airway disease...
February 24, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28231568/fiber-connections-of-the-caudal-corpus-cerebelli-with-special-reference-to-the-intrinsic-circuitry-in-a-teleost-oreochromis-niloticus
#2
Kosuke Imura, Naoyuki Yamamoto, Masami Yoshimoto, Masato Endo, Kengo Funakoshi, Hironobu Ito
The caudal part of the corpus cerebelli of Nile tilapia can be divided into dorsal and ventral regions. The granule cell layer of the dorsal (dGL) and ventral (vGL) regions of the caudal corpus cerebelli is known to receive indirect inputs from the telencephalon relayed by the nucleus paracommissuralis. The descending pathways are topographically organized, and the dGL and vGL receive inputs from different dorsal telencephalic parts. The caudal corpus cerebelli, in turn, projects extracerebellar efferents. However, it remains unknown how the descending telencephalic inputs are processed within the cerebellum...
February 24, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28230172/evidence-for-critical-role-of-lymphocyte-cytosolic-protein-1-in-oral-cancer
#3
Nao Koide, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Sho Ishida, Toshihiro Shimizu, Yasushi Kimura, Isao Miyamoto, Shusaku Yoshimura, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Lymphocyte cytosolic protein 1 (LCP1), a member of actin-binding protein of the plastin family, has been identified in several malignant tumors of non-hematopoietic sites, such as the colon, prostate, and breast. However, little is known about the roles of LCP1 in oral squamous cell carcinomas (OSCCs). This present study sought to clarify the clinical relevance of LCP1 in OSCCs and investigate possible clinical applications for treating OSCCs by regulating LCP1 expression. We found up-regulation of LCP1in OSCCs compared with normal counterparts using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), immunoblotting, and immunohistochemistry (P < 0...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229363/message-from-editor-in-chief-and-deputy-editors-10th-anniversary-of-radiological-physics-and-technology
#4
EDITORIAL
Kunio Doi, Fujio Araki, Masahiro Endo, Tomoyuki Hasegawa, Shigehiko Katsuragawa, Yoshie Kodera, Shigeru Sanada
No abstract text is available yet for this article.
February 22, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28229296/increased-expression-of-il12b-mrna-transcribed-from-the-risk-haplotype-for-crohn-s-disease-is-a-risk-factor-for-disease-relapse-in-japanese-patients
#5
Yoichi Kakuta, Tomoya Kimura, Kenichi Negoro, Masatake Kuroha, Hisashi Shiga, Katsuya Endo, Yoshitaka Kinouchi, Tooru Shimosegawa
BACKGROUND: IL12B is a promising candidate for a susceptibility gene in Crohn's disease (CD). The aim of this study was to perform a candidate gene analysis of IL12B in Japanese CD patients, investigate whether the genotype is associated with disease phenotypes, and determine how the risk allele affects susceptibility to CD. METHODS: Three hundred seventy-five patients with CD, 265 patients with ulcerative colitis, and 463 healthy controls were examined. Ten single-nucleotide polymorphisms (SNPs) around IL12B were genotyped...
February 22, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28229148/uniform-and-janus-like-nanoparticles-in-contact-with-vesicles-energy-landscapes-and-curvature-induced-forces
#6
Jaime Agudo-Canalejo, Reinhard Lipowsky
Biological membranes and lipid vesicles often display complex shapes with non-uniform membrane curvature. When adhesive nanoparticles with chemically uniform surfaces come into contact with such membranes, they exhibit four different engulfment regimes as recently shown by a systematic stability analysis. Depending on the local curvature of the membrane, the particles either remain free, become partially or completely engulfed by the membrane, or display bistability between free and completely engulfed states...
February 23, 2017: Soft Matter
https://www.readbyqxmd.com/read/28228846/decoupling-the-downstream-effects-of-germline-nuclear-rnai-reveals-that-h3k9me3-is-dispensable-for-heritable-rnai-and-the-maintenance-of-endogenous-sirna-mediated-transcriptional-silencing-in-caenorhabditis-elegans
#7
Natallia Kalinava, Julie Zhouli Ni, Kimberly Peterman, Esteban Chen, Sam Guoping Gu
BACKGROUND: Germline nuclear RNAi in C. elegans is a transgenerational gene-silencing pathway that leads to H3K9 trimethylation (H3K9me3) and transcriptional silencing at the target genes. H3K9me3 induced by either exogenous double-stranded RNA (dsRNA) or endogenous siRNA (endo-siRNA) is highly specific to the target loci and transgenerationally heritable. Despite these features, the role of H3K9me3 in siRNA-mediated transcriptional silencing and inheritance of the silencing state at native target genes is unclear...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28228093/comparative-profiling-of-hepatopancreas-transcriptomes-in-satiated-and-starving-pomacea-canaliculata
#8
Lei Yang, Tian-Yin Cheng, Fei-Yan Zhao
BACKGROUND: Although Pomacea canaliculata is native to South and Central America, it has become one of the most abundant invasive species worldwide and causes extensive damage to agriculture and horticulture. Conventional physical and chemical techniques have been used to eliminate P. canaliculata, but the effects are not ideal. Therefore, it is important to devise a new method based on a greater understanding of the biology of P. canaliculata. However, the molecular mechanisms underlying digestion and absorption in P...
February 22, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28226954/multiple-regression-based-imputation-for-individualizing-template-human-model-from-a-small-number-of-measured-dimensions
#9
Ryuki Nohara, Yui Endo, Akihiko Murai, Hiroshi Takemura, Makiko Kouchi, Mitsunori Tada, Ryuki Nohara, Yui Endo, Akihiko Murai, Hiroshi Takemura, Makiko Kouchi, Mitsunori Tada, Akihiko Murai, Ryuki Nohara, Hiroshi Takemura, Makiko Kouchi, Yui Endo, Mitsunori Tada
Individual human models are usually created by direct 3D scanning or deforming a template model according to the measured dimensions. In this paper, we propose a method to estimate all the necessary dimensions (full set) for the human model individualization from a small number of measured dimensions (subset) and human dimension database. For this purpose, we solved multiple regression equation from the dimension database given full set dimensions as the objective variable and subset dimensions as the explanatory variables...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226430/postural-flexibility-during-quiet-standing-in-healthy-elderly-and-patients-with-parkinson-s-disease
#10
Kazuyuki Matsuda, Yasuyuki Suzuki, Naoya Yoshikawa, Tomohisa Yamamoto, Ken Kiyono, Takao Tanahashi, Takuyuki Endo, Kei Fukada, Kunihiko Nomura, Saburo Sakoda, Taishin Nomura, Kazuyuki Matsuda, Yasuyuki Suzuki, Naoya Yoshikawa, Tomohisa Yamamoto, Ken Kiyono, Takao Tanahashi, Takuyuki Endo, Kei Fukada, Kunihiko Nomura, Saburo Sakoda, Taishin Nomura, Kei Fukada, Naoya Yoshikawa, Tomohisa Yamamoto, Takuyuki Endo, Kunihiko Nomura, Taishin Nomura, Kazuyuki Matsuda, Ken Kiyono, Takao Tanahashi, Saburo Sakoda, Yasuyuki Suzuki
Postural instability is one of the predominant symptoms of Parkinson's disease (PD). Despite its significant impact on the deterioration in quality of life in PD patients, mechanistic causes of the instability have not been clarified. Joint inflexibility at ankle and hip joints might be such a major cause, leading to small variability in the center of pressure (CoP) during quiet stance. However, this conjecture is still controversial. Thus, quantitative characterization of CoP patterns during quiet stance in PD patients remains a matter of research...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225615/structural-characterization-and-in-vitro-fermentation-of-%C3%AE-mannooligosaccharides-produced-from-locust-bean-gum-by-gh-26-endo-%C3%AE-1-4-mannanase-manb-1601
#11
Praveen Kumar Srivastava, Deepesh Panwar, Harish Prashanth Kv, Mukesh Kapoor
Size exclusion chromatography of β-mannooligosaccharides (β-MOS) mixture, obtained from ManB-1601 hydrolysis of locust bean gum, resulted in separation of oligosaccharides with varied degree of polymerization (DP 2, 3 and 5). The oligosaccharides were structurally [ESI-MS, FTIR, XRD, TGA and NMR (1H and 13C)] and functionally (in vitro fermentation) characterized. DP2 oligosaccharide was composed of two species (A) mannopyranose β-1,4 mannopyranose and (B) α-1,6-galactosyl-mannopyranose, while DP3 oligosaccharide showed presence of only one species i...
February 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28225553/correlations-among-mercury-concentration-and-stable-isotope-ratios-of-carbon-and-nitrogen-of-amino-acids-in-scalp-hair-from-whale-meat-eaters-and-heavy-fish-eaters
#12
Tetsuya Endo, Hideki Ogasawara, Moriaki Hayasaka, Yohei Hotta, Osamu Kimura, Klaus J Petzke
RATIONALE: As Hg accumulation in marine animals generally increases with increased trophic level (δ(15) N values) through the food web, predators accumulate higher levels of Hg. The main source of human Hg intake is the consumption of fish and other marine animals, and Hg concentration in scalp hair is the preferred marker for evaluating consumption of marine animals. Difference of δ(15) N values between trophic and source amino acids of human consumers could enable us to estimate the trophic level of consumer without knowing the bulk δ(15) N value of their prey...
February 22, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28225296/development-and-validation-of-an-lc-ms-ms-method-for-simultaneously-determining-doxapram-and-keto-doxapram-in-human-serum
#13
Yuki Suzuki, Noboru Kamada, Hitoshi Ohno, Yoshikazu Abe, Takuro Endo, Mamoru Kobayashi
AIM: Doxapram, a respiratory stimulant, is used to treat apnea. A reliable method of determining doxapram in blood is required for monitoring purposes. RESULTS: Doxapram, keto-doxapram (active metabolite) and propranolol (internal standard) were extracted from human serum by protein precipitation and plate filtration. Molecular ions were generated by electrospray ionization in positive ion mode, and the ions were analyzed using a triple-quadrupole mass spectrometer...
February 22, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28224919/characteristics-and-regulatory-pathway-of-the-prupesep1-sepallata-gene-during-ripening-and-softening-in-peach-fruits
#14
Jinjin Li, Fang Li, Ming Qian, Mingyu Han, Hangkong Liu, Dong Zhang, Juanjuan Ma, Caiping Zhao
SEPALLATA genes are members of a subfamily of MADS-box transcription factors, and have essential roles in floral organ development and fruit ripening. In this study, the PrupeSEP1 gene was cloned from peach flesh. Its deduced amino acid sequence was very similar to that of MdMADS8 and MdMADS9 in apple and MADS-RIN-like in strawberry. During storage of melting flesh (MF) peach, the pattern of SEP1 expression was similar to that of ethylene biosynthesis and ethylene signal transduction-related gene expression (EIN2 and ETR2)...
April 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28224762/stereoisomerization-of-cyclic-silanols
#15
Hisayuki Endo, Nobuhiro Takeda, Masafumi Unno
Stereoisomerization of readily available all-cis-1,3,5,7-tetrahydroxy-1,3,5,7-tetraisobutylcyclotetrasiloxane (1a) was carried out in acidic condition to afford cis-trans-cis (1b), all-trans (1c), and cis-cis-trans (1d) isomers. Reaction mixture could be easily separated into 1a and a mixture of 1b, 1c, and 1d by the treatment with chloroform. Mixture of 1b, 1c, and 1d were further isolated and each structure was identified. The experimental results indicated that the most of plausible mechanism is substitution reaction of silicon center via pentacoordinate intermediate without cyclic siloxane bond cleavage reaction...
February 22, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28224709/secure-overlap-stapling-using-a-linear-stapler-with-bioabsorbable-polyglycolic-acid-felt
#16
Masanori Naito, Takeo Sato, Takatoshi Nakamura, Takahiro Yamanashi, Hirohisa Miura, Atsuko Tsutsui, Masahiko Watanabe
INTRODUCTION: Despite the availability of various anastomosis techniques, postoperative anastomotic complications such as anastomosis failure and bleeding develop in some patients. Automatic suturing devices have been widely used for gastrointestinal anastomosis. However, overly thick or thin tissue, displacement of tissue, and the creation of a staple-on-staple site may lead to incomplete staple formation. These factors are considered to be related to postoperative complications such as anastomosis failure...
February 22, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28223224/transient-receptor-potential-canonical-type-3-channels-interactions-role-and-relevance-a-vascular-focus
#17
REVIEW
T Hilton Grayson, Timothy V Murphy, Shaun L Sandow
Transient receptor potential canonical type 3 channels (TRPC3) are expressed in neural, cardiac, respiratory and vascular tissues, with both similarities and differences between human and animal models for the same cell types. In common with all members of the six subfamilies of TRP channels, TRPC3 are non-voltage gated, non-selective cation channels that are mainly permeated by Ca(2+), and have distinct molecular, biophysical, anatomical and functional properties. TRP channels are present in excitable and non-excitable cells where they sense and respond to a wide variety of physical and chemical stimuli...
February 13, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28223057/patency-of-saphenous-vein-grafts-using-the-pas-port-system-during-coronary-artery-bypass-surgery
#18
Hiroshi Kubota, Hidehito Endo, Hikaru Ishii, Hiroshi Tsuchiya, Yu Takahashi, Yusuke Inaba, Mio Noma, Akihiro Yoshimoto, Satoshi Higuchi, Hideyasu Kohshoh, Seiichi Taniai, Haruhisa Ishiguro, Hideaki Yoshino, Kenichi Sudo
BACKGROUND: Several proximal anastomosis devices have been developed to shorten the time required for a proximal anastomosis and to avoid aortic cross-/side-clamping during coronary artery bypass grafting. This study retrospectively examined the patency of saphenous vein grafts (SVGs) using the PAS-Port System (Cardia Inc, Redwood City, CA). METHODS: From 2004 to 2014, 451 patients underwent coronary artery bypass graft operations requiring at least 1 proximal anastomosis using a PAS-Port device...
February 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28221030/control-of-grafting-density-and-distribution-in-graft-polymers-by-living-ring-opening-metathesis-copolymerization
#19
Tzu-Pin Lin, Alice B Chang, Hsiang-Yun Chen, Allegra L Liberman-Martin, Christopher M Bates, Matthew J Voegtle, Christina A Bauer, Robert H Grubbs
Control over polymer sequence and architecture is crucial to both understanding structure-property relationships and designing functional materials. In pursuit of these goals, we developed a new synthetic approach that enables facile manipulation of the density and distribution of grafts in polymers via living ring-opening metathesis polymerization (ROMP). Discrete endo,exo-norbornenyl dialkylesters (dimethyl DME, diethyl DEE, di-n-butyl DBE) were strategically designed to copolymerize with a norbornene-functionalized polystyrene (PS), polylactide (PLA), or polydimethylsiloxane (PDMS) macromonomer mediated by the 3rd generation catalyst (G3)...
February 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28220903/application-of-carbohydrate-arrays-coupled-with-mass-spectrometry-to-detect-activity-of-plant-polysaccharide-degradative-enzymes-from-the-fungus-aspergillus-niger
#20
Jolanda M van Munster, Baptiste Thomas, Michel Riese, Adrienne L Davis, Christopher J Gray, David B Archer, Sabine L Flitsch
Renewables-based biotechnology depends on enzymes to degrade plant lignocellulose to simple sugars that are converted to fuels or high-value products. Identification and characterization of such lignocellulose degradative enzymes could be fast-tracked by availability of an enzyme activity measurement method that is fast, label-free, uses minimal resources and allows direct identification of generated products. We developed such a method by applying carbohydrate arrays coupled with MALDI-ToF mass spectrometry to identify reaction products of carbohydrate active enzymes (CAZymes) of the filamentous fungus Aspergillus niger...
February 21, 2017: Scientific Reports
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