Hoda A Salem, Karema Abu-Elfotuh, Sharifa Alzahrani, Nermin I Rizk, Howaida S Ali, Nehal Elsherbiny, Alhanouf Aljohani, Ahmed M E Hamdan, Panneerselvam Chellasamy, Nada S Abdou, Ayah M H Gowifel, Alshaymaa Darwish, Osama Mohamed Ibrahim, Zakaria Y Abd Elmageed
Parkinson's disease (PD) is a gradual deterioration of dopaminergic neurons, leading to motor impairments. Social isolation (SI), a recognized stressor, has recently gained attention as a potential influencing factor in the progress of neurodegenerative illnesses. We aimed to investigate the intricate relationship between SI and PD progression, both independently and in the presence of manganese chloride (MnCl2 ), while evaluating the punicalagin (PUN) therapeutic effects, a natural compound established for its cytoprotective, anti-inflammatory, and anti-apoptotic activities...
October 4, 2023: Pharmaceutics