keyword
Keywords heart and ischemia and mitocho...

heart and ischemia and mitochondria

https://read.qxmd.com/read/38053866/cardiac-damage-following-renal-ischemia-reperfusion-injury-increased-with-excessive-consumption-of-high-fat-diet-but-enhanced-the-cardiac-resistance-to-reperfusion-stress-in-rat
#21
JOURNAL ARTICLE
Priyanka N Prem, Gino A Kurian
Renal ischemia-reperfusion (IR) injury inflicts remote cardiac dysfunction. Studies on rats fed with a high-fat diet (HD) showed contradictory results: some demonstrated increased sensitivity of the heart and kidney to IR injury, while others reported resistance. In this study, we examined cardiac dysfunction and compromised cardiac tolerance associated with renal IR in HD and standard diet (SD) fed rats. Male Wistar rats fed with HD or SD diet for 16 weeks were subjected to either renal sham or IR protocol (bilateral clamping for 45 min and reperfusion for 24 h)...
November 2023: Heliyon
https://read.qxmd.com/read/38043869/redox-differences-between-rat-neonatal-and-adult-cardiomyocytes-under-hypoxia
#22
JOURNAL ARTICLE
Alexandra D Ivanova, Daria A Kotova, Yulia V Khramova, Ksenia I Morozova, Daria V Serebryanaya, Zhanna V Bochkova, Anastasia D Sergeeva, Anastasiya S Panova, Ivan A Katrukha, Aleksandr A Moshchenko, Vladimir A Oleinikov, Alexey V Semyanov, Vsevolod V Belousov, Alexey G Katrukha, Nadezda Brazhe, Dmitry S Bilan
It is generally accepted that oxidative stress plays a key role in the development of ischemia-reperfusion injury in ischemic heart disease. However, the mechanisms how reactive oxygen species trigger cellular damage are not fully understood. Our study investigates redox state and highly reactive substances within neonatal and adult cardiomyocytes under hypoxia conditions. We have found that hypoxia induced an increase in H2 O2 production in adult cardiomyocytes, while neonatal cardiomyocytes experienced a decrease in H2 O2 levels...
December 1, 2023: Free Radical Biology & Medicine
https://read.qxmd.com/read/38038719/cardiovascular-aging-spotlight-on-mitochondria
#23
REVIEW
Md Akkas Ali, Rachel Gioscia-Ryan, Dongli Yang, Nadia R Sutton, Daniel J Tyrrell
Mitochondria are cellular organelles critical for ATP production and are particularly relevant to cardiovascular diseases including heart failure, atherosclerosis, ischemia reperfusion injury, and cardiomyopathies. With advancing age, even in the absence of clinical disease, mitochondrial homeostasis becomes disrupted (e.g. redox balance, mitochondrial DNA damage, oxidative metabolism, and mitochondrial quality control). Mitochondrial dysregulation leads to the accumulation of damaged and dysfunctional mitochondria, producing excessive reactive oxygen species and perpetuating mitochondrial dysfunction...
December 1, 2023: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/38020895/mitochondrial-quality-control-in-health-and-cardiovascular-diseases
#24
REVIEW
Asli E Atici, Timothy R Crother, Magali Noval Rivas
Cardiovascular diseases (CVDs) are one of the primary causes of mortality worldwide. An optimal mitochondrial function is central to supplying tissues with high energy demand, such as the cardiovascular system. In addition to producing ATP as a power source, mitochondria are also heavily involved in adaptation to environmental stress and fine-tuning tissue functions. Mitochondrial quality control (MQC) through fission, fusion, mitophagy, and biogenesis ensures the clearance of dysfunctional mitochondria and preserves mitochondrial homeostasis in cardiovascular tissues...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38004374/pm-2-5-exposure-linked-mitochondrial-dysfunction-negates-sb216763-mediated-cardio-protection-against-myocardial-ischemia-reperfusion-injury
#25
JOURNAL ARTICLE
Bhavana Sivakumar, Ahmed Nadeem, Mashooq Ahmad Dar, Gino A Kurian
GSK3β is a promising target for treating various disease conditions, including myocardial ischemia-reperfusion injury (IR). This study investigated the potential of GSK3β as a novel drug for managing IR in rats exposed to PM2.5 for 1 day and up to 21 days. Female Wistar rats were exposed to PM2.5 at a concentration of 250 µg/m3 for 3 h daily for either a single day or 21 days. After exposure, the isolated rat hearts underwent 30 min of ischemia followed by 60 min of reperfusion. GSK3β inhibition effectively reduced IR injury in rat hearts from animals exposed to PM2...
November 20, 2023: Life
https://read.qxmd.com/read/37979443/%C3%AE-hydroxybutyrate-administered-at-reperfusion-reduces-infarct-size-and-preserves-cardiac-function-by-improving-mitochondrial-function-through-autophagy-in-male-mice
#26
JOURNAL ARTICLE
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A Benavides, Victor M Darley-Usmar, Martin E Young, Scott W Ballinger, Sumanth D Prabhu, Cheng Zhang, Min Xie
Ischemia/reperfusion (I/R) injury after revascularization contributes ∼50% of infarct size and causes heart failure, for which no established clinical treatment exists. β-hydroxybutyrate (β-OHB), which serves as both an energy source and a signaling molecule, has recently been reported to be cardioprotective when administered immediately before I/R and continuously after reperfusion. This study aims to determine whether administering β-OHB at the time of reperfusion with a single dose can alleviate I/R injury and, if so, to define the mechanisms involved...
November 16, 2023: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/37955687/targeting-mitochondrial-shape-at-the-heart-of-cardioprotection
#27
JOURNAL ARTICLE
Sauri Hernandez-Resendiz, Aishwarya Prakash, Sze Jie Loo, Martina Semenzato, Kroekkiat Chinda, Gustavo E Crespo-Avilan, Linh Chi Dam, Shengjie Lu, Luca Scorrano, Derek J Hausenloy
There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia-reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarction (AMI). In this regard, perturbations in mitochondrial morphology with an imbalance in mitochondrial fusion and fission can disrupt mitochondrial metabolism, calcium homeostasis, and reactive oxygen species production, factors which are all known to be critical determinants of cardiomyocyte death following acute myocardial IRI...
November 13, 2023: Basic Research in Cardiology
https://read.qxmd.com/read/37943012/hydrolytic-activity-of-mitochondrial-f-1-f-o-atp-synthase-as-a-target-for-myocardial-ischemia-reperfusion-injury-discovery-and-in-vitro-and-in-vivo-evaluation-of-novel-inhibitors
#28
JOURNAL ARTICLE
Panagiota-Efstathia Nikolaou, George Lambrinidis, Maria Georgiou, Dimitrios Karagiannis, Panagiotis Efentakis, Pavlos Bessis-Lazarou, Konstantina Founta, Stavros Kampoukos, Vasilis Konstantin, Carlos M Palmeira, Sean M Davidson, Nikolaos Lougiakis, Panagiotis Marakos, Nicole Pouli, Emmanuel Mikros, Ioanna Andreadou
F1 FO -ATP synthase is the mitochondrial complex responsible for ATP production. During myocardial ischemia, it reverses its activity, hydrolyzing ATP and leading to energetic deficit and cardiac injury. We aimed to discover novel inhibitors of ATP hydrolysis, accessing the druggability of the target within ischemia(I)/reperfusion(R) injury. New molecular scaffolds were revealed using ligand-based virtual screening methods. Fifty-five compounds were tested on isolated murine heart mitochondria and H9c2 cells for their inhibitory activity...
November 9, 2023: Journal of Medicinal Chemistry
https://read.qxmd.com/read/37939779/a-review-for-the-correlation-between-optic-atrophy-1-dependent-mitochondrial-fusion-and-cardiovascular-disorders
#29
REVIEW
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Mitochondrial dynamics homeostasis is sustained by continuous and balanced fission and fusion, which are determinants of morphology, abundance, biogenesis and mitophagy of mitochondria. Optic atrophy 1 (OPA1), as the only inner mitochondrial membrane fusion protein, plays a key role in stabilizing mitochondrial dynamics. The disturbance of mitochondrial dynamics contributes to the pathophysiological progress of cardiovascular disorders, which are the main cause of death worldwide in recent decades and result in tremendous social burden...
November 6, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37923160/cardioprotective-effect-of-interleukin-11-against-warm-ischemia-reperfusion-injury-in-a-rat-heart-donor-model
#30
JOURNAL ARTICLE
Tomoki Sakata, Hiroki Kohno, Tomohiko Inui, Hiroki Ikeuchi, Yuki Shiko, Yohei Kawasaki, Shota Suzuki, Shota Tanaka, Masanori Obana, Kiyotake Ishikawa, Yasushi Fujio, Goro Matsumiya
Shortage of donor organs for heart transplantation is a worldwide problem. Donation after circulatory death (DCD) has been proposed to expand the donor pool. However, in contrast to the donation after brain death that undergoes immediate cold preservation, warm ischemia and subsequent reperfusion injury are inevitable in DCD. It has been reported that interleukin-11 (IL-11) mitigates ischemia-reperfusion injury in rodent models of myocardial infarction and donation after brain death heart transplantation. We hypothesized that IL-11 also offers benefit to warm ischemia in an experimental model of cardiac transplantation that resembles DCD...
November 1, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37908314/dexmedetomidine-ameliorates-cardiac-ischemia-reperfusion-injury-by-enhancing-autophagy-through-activation-of-the-ampk-sirt3-pathway
#31
JOURNAL ARTICLE
Hong He, Peng Liu, Peng Li
OBJECTIVE: Myocardial ischemia-reperfusion (I/R) injury is a detrimental disease, resulting in high morbidity and mortality globally. In this study, we aimed to investigate the role of Dex in mitigating cardiac I/R injury. METHODS: H9c2 cells were treated with Dex (1 μM) for 24 h followed by oxygen-glucose deprivation/re-oxygenation (OGD/R). ANP and BNP mRNA of H9c2 cells and the LDH release were measured. Apoptosis of H9c2 cells was analyzed by flow cytometry...
2023: Drug Design, Development and Therapy
https://read.qxmd.com/read/37904726/neuroprotective-effects-of-gemfibrozil-in-neurological-disorders-focus-on-inflammation-and-molecular-mechanisms
#32
REVIEW
Mehraveh Sadeghi Ivraghi, Mohammad Yasin Zamanian, Reena Gupta, Harun Achmad, Hashem O Alsaab, Ahmed Hjazi, Rosario Mireya Romero-Parra, Enas R Alwaily, Beneen M Hussien, Elham Hakimizadeh
BACKGROUND: Gemfibrozil (Gem) is a drug that has been shown to activate PPAR-α, a nuclear receptor that plays a key role in regulating lipid metabolism. Gem is used to lower the levels of triglycerides and reduce the risk of coronary heart disease in patients. Experimental studies in vitro and in vivo have shown that Gem can prevent or slow the progression of neurological disorders (NDs), including cerebral ischemia (CI), Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS)...
October 30, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37895224/role-of-mitochondrial-dynamics-in-heart-diseases
#33
REVIEW
Takeshi Tokuyama, Shigeru Yanagi
Mitochondrial dynamics, including fission and fusion processes, are essential for heart health. Mitochondria, the powerhouses of cells, maintain their integrity through continuous cycles of biogenesis, fission, fusion, and degradation. Mitochondria are relatively immobile in the adult heart, but their morphological changes due to mitochondrial morphology factors are critical for cellular functions such as energy production, organelle integrity, and stress response. Mitochondrial fusion proteins, particularly Mfn1/2 and Opa1, play multiple roles beyond their pro-fusion effects, such as endoplasmic reticulum tethering, mitophagy, cristae remodeling, and apoptosis regulation...
September 26, 2023: Genes
https://read.qxmd.com/read/37891898/beneficial-effects-of-halogenated-anesthetics-in-cardiomyocytes-the-role-of-mitochondria
#34
REVIEW
José Luis Guerrero-Orriach, María Dolores Carmona-Luque, Aida Raigón-Ponferrada
In the last few years, the use of anesthetic drugs has been related to effects other than those initially related to their fundamental effect, hypnosis. Halogenated anesthetics, mainly sevoflurane, have been used as a therapeutic tool in patients undergoing cardiac surgery, thanks to the beneficial effect of the cardiac protection they generate. This effect has been described in several research studies. The mechanism by which they produce this effect has been associated with the effects generated by anesthetic preconditioning and postconditioning...
September 30, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37880513/dna-hypomethylation-by-fisetin-preserves-mitochondria-functional-genes-and-contributes-to-the-protection-of-i-r-rat-heart
#35
JOURNAL ARTICLE
Sri Rahavi Boovarahan, Kirankumar Balu, Priyanka Prem, Bhavana Sivakumar, Gino A Kurian
Myocardial I/R can alter the expression of different sets of cardiac genes that negatively influence the I/R outcome via epigenetic modifications. Fisetin is known to be cardioprotective against I/R, but its underlying epigenetic mode of action is not known and is addressed in the present study. Male Wistar rats were subjected to I/R by using the Langendorff perfusion system. Fisetin (20 mg/kg; i.p.) was administered before I/R induction, followed by the measurement of cardiac injury, hemodynamics, physiological indices, the differential expression of genes that regulate DNA methylation, and the function of mitochondria were performed...
October 25, 2023: Functional & Integrative Genomics
https://read.qxmd.com/read/37880253/continuous-short-term-acclimation-to-moderate-cold-elicits-cardioprotection-in-rats-and-alters-%C3%AE-adrenergic-signaling-and-immune-status
#36
JOURNAL ARTICLE
Aneta Marvanova, Petr Kasik, Barbara Elsnicova, Veronika Tibenska, František Galatik, Daniela Hornikova, Veronika Zvolska, Pavel Vebr, Petr Vodicka, Lucie Hejnova, Petr Matous, Barbara Szeiff Bacova, Matus Sykora, Jiri Novotny, Jiri Neuzil, Frantisek Kolar, Olga Novakova, Jitka M Zurmanova
Moderate cold acclimation (MCA) is a non-invasive intervention mitigating effects of various pathological conditions including myocardial infarction. We aim to determine the shortest cardioprotective regimen of MCA and the response of β1/2/3-adrenoceptors (β-AR), its downstream signaling, and inflammatory status, which play a role in cell-survival during myocardial infarction. Adult male Wistar rats were acclimated (9 °C, 1-3-10 days). Infarct size, echocardiography, western blotting, ELISA, mitochondrial respirometry, receptor binding assay, and quantitative immunofluorescence microscopy were carried out on left ventricular myocardium and brown adipose tissue (BAT)...
October 25, 2023: Scientific Reports
https://read.qxmd.com/read/37843218/mitochondrial-dysfunction-and-quality-control-lie-at-the-heart-of-subarachnoid-hemorrhage
#37
REVIEW
Jiatong Zhang, Qi Zhu, Jie Wang, Zheng Peng, Zong Zhuang, Chunhua Hang, Wei Li
The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a decrease in cerebral perfusion pressure and a reduction in cerebral blood flow. Mitochondria are directly affected by direct factors such as ischemia, hypoxia, excitotoxicity, and toxicity of free hemoglobin and its degradation products, which trigger mitochondrial dysfunction. Dysfunctional mitochondria release large amounts of reactive oxygen species, inflammatory mediators, and apoptotic proteins that activate apoptotic pathways, further damaging cells...
April 2024: Neural Regeneration Research
https://read.qxmd.com/read/37792081/recent-advances-on-the-role-of-monoamine-oxidases-in-cardiac-pathophysiology
#38
JOURNAL ARTICLE
Nina Kaludercic, Ruth Jepchirchir Arusei, Fabio Di Lisa
Numerous physiological and pathological roles have been attributed to the formation of mitochondrial reactive oxygen species (ROS). However, the individual contribution of different mitochondrial processes independently of bioenergetics remains elusive and clinical treatments unavailable. A notable exception to this complexity is found in the case of monoamine oxidases (MAOs). Unlike other ROS-producing enzymes, especially within mitochondria, MAOs possess a distinct combination of defined molecular structure, substrate specificity, and clinically accessible inhibitors...
October 4, 2023: Basic Research in Cardiology
https://read.qxmd.com/read/37791311/ketone-bodies-rescue-mitochondrial-dysfunction-via-epigenetic-remodeling
#39
JOURNAL ARTICLE
Jessica Gambardella, Stanislovas S Jankauskas, Urna Kansakar, Fahimeh Varzideh, Roberta Avvisato, Nella Prevete, Simone Sidoli, Pasquale Mone, Xujun Wang, Angela Lombardi, Gaetano Santulli
Ischemic cardiac disease is a major cause of mortality worldwide. However, the exact molecular processes underlying this disorder are not fully known. This study includes a comprehensive and coordinated set of in vivo and in vitro experiments using human cardiac specimens from patients with postischemic heart failure (HF) and healthy control subjects, a murine model of HF, and cellular systems. These approaches identified for the first time a specific pattern of maladaptive chromatin remodeling, namely a double methylation of histone 3 at lysine 27 and a single methylation at lysine 36 (H3_K27me2K36me1) consistently induced by ischemic injury in all these settings: human HF; murine HF; and in vitro models...
September 2023: JACC. Basic to Translational Science
https://read.qxmd.com/read/37770199/-serum-glucocorticoid-regulated-kinase-1-in-ischemia-reperfusion-injury-blessing-or-curse
#40
JOURNAL ARTICLE
Mahmood S Mozaffari
The family of serum-glucocorticoid-regulated kinase (SGK) consists of three paralogs- SGK-1, SGK-2 and SGK-3 with SGK-1 being the better studied. Indeed, recognition of the role of SGK-1 in regulation of cell survival and proliferation has led to introduction of a number of small-molecule inhibitors for some types of cancer. In addition, SGK-1 regulates major physiological effects, such as renal solute transport, and contributes to the pathogenesis of non-neoplastic conditions involving major organs including the heart and the kidney...
September 28, 2023: Journal of Pharmacology and Experimental Therapeutics
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