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Artificial pancreas

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https://www.readbyqxmd.com/read/27918508/the-artificial-pancreas-gets-real
#1
Ellen Sheng
No abstract text is available yet for this article.
October 18, 2016: Scientific American
https://www.readbyqxmd.com/read/27913173/hacking-diabetes-diy-artificial-pancreas-systems
#2
Conor Farrington
No abstract text is available yet for this article.
November 29, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27912033/human-factor-considerations-for-artificial-pancreas-research
#3
Linda A Gonder-Frederick, Jesse H Grabman, Jaclyn A Shepard
No abstract text is available yet for this article.
December 2, 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27877104/sweet-taste-receptor-serves-to-activate-glucose-and-leptin-responsive-neurons-in-the-hypothalamic-arcuate-nucleus-and-participates-in-glucose-responsiveness
#4
Daisuke Kohno, Miho Koike, Yuzo Ninomiya, Itaru Kojima, Tadahiro Kitamura, Toshihiko Yada
The hypothalamic feeding center plays an important role in energy homeostasis. In the feeding center, whole-body energy signals including hormones and nutrients are sensed, processed, and integrated. As a result, food intake and energy expenditure are regulated. Two types of glucose-sensing neurons exist in the hypothalamic arcuate nucleus (ARC): glucose-excited neurons and glucose-inhibited neurons. While some molecules are known to be related to glucose sensing in the hypothalamus, the mechanisms underlying glucose sensing in the hypothalamus are not fully understood...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27852685/evaluating-the-experience-of-children-with-type-1-diabetes-and-their-parents-taking-part-in-an-artificial-pancreas-clinical-trial-over-multiple-days-in-a-diabetes-camp-setting
#5
Alda Troncone, Riccardo Bonfanti, Dario Iafusco, Ivana Rabbone, Alberto Sabbion, Riccardo Schiaffini, Alfonso Galderisi, Marco Marigliano, Novella Rapini, Andrea Rigamonti, Davide Tinti, Valeria Vallone, Angela Zanfardino, Federico Boscari, Simone Del Favero, Silvia Galasso, Giordano Lanzola, Mirko Messori, Federico Di Palma, Roberto Visentin, Roberta Calore, Yenny Leal, Lalo Magni, Eleonora Losiouk, Daniel Chernavvsky, Silvana Quaglini, Claudio Cobelli, Daniela Bruttomesso
OBJECTIVE: To explore the experiences of children with type 1 diabetes and their parents taking part in an artificial pancreas (AP) clinical trial during a 7-day summer camp. RESEARCH DESIGN AND METHODS: A semistructured interview, composed of 14 questions based on the Technology Acceptance Model, was conducted at the end of the clinical trial. Participants also completed the Diabetes Treatment Satisfaction Questionnaire (DTSQ, parent version) and the AP Acceptance Questionnaire...
December 2016: Diabetes Care
https://www.readbyqxmd.com/read/27836235/closed-loop-insulin-delivery-in-inpatients-with-type-2-diabetes-a-randomised-parallel-group-trial
#6
Hood Thabit, Sara Hartnell, Janet M Allen, Andrea Lake, Malgorzata E Wilinska, Yue Ruan, Mark L Evans, Anthony P Coll, Roman Hovorka
BACKGROUND: We assessed whether fully closed-loop insulin delivery (the so-called artificial pancreas) is safe and effective compared with standard subcutaneous insulin therapy in patients with type 2 diabetes in the general ward. METHODS: For this single-centre, open-label, parallel-group, randomised controlled trial, we enrolled patients aged 18 years or older with type 2 diabetes who were receiving insulin therapy. Patients were recruited from general wards at Addenbrooke's Hospital, Cambridge, UK...
November 8, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27784829/coordination-or-collision-the-intersection-of-diabetes-care-cybersecurity-and-cloud-based-computing
#7
Scott Thiel, Jennifer Mitchell, Jim Williams
Diagnosis and treatment of diabetes changed little from the Middle Ages through the early 19th century, when the first chemical test for the condition was developed. In the 20th century, advances in diabetes management gained momentum with home-use diagnostic devices and mass-produced insulin. In the 21st century, technological developments around diabetes are advancing so rapidly that a small, discrete system of medical devices that serve as an artificial pancreas are now possible. In this article, we assert that medical device interoperability and cyber security are necessary preconditions for safe, effective, and reliable widespread use of the artificial pancreas system...
October 26, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27749113/impact-of-meal-constituents-on-artificial-pancreas-algorithms
#8
Enrique Campos-Náñez, Boris P Kovatchev
No abstract text is available yet for this article.
October 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27743864/continuous-operation-of-an-ultra-low-power-microcontroller-using-glucose-as-the-sole-energy-source
#9
Inyoung Lee, Takashi Sode, Noya Loew, Wakako Tsugawa, Christopher Robin Lowe, Koji Sode
An ultimate goal for those engaged in research to develop implantable medical devices is to develop mechatronic implantable artificial organs such as artificial pancreas. Such devices would comprise at least a sensor module, an actuator module, and a controller module. For the development of optimal mechatronic implantable artificial organs, these modules should be self-powered and autonomously operated. In this study, we aimed to develop a microcontroller using the BioCapacitor principle. A direct electron transfer type glucose dehydrogenase was immobilized onto mesoporous carbon, and then deposited on the surface of a miniaturized Au electrode (7mm(2)) to prepare a miniaturized enzyme anode...
September 28, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27738936/selective-osmotic-shock-sos-based-islet-isolation-for-microencapsulation
#10
Kevin Enck, John Patrick McQuilling, Giuseppe Orlando, Riccardo Tamburrini, Sittadjody Sivanandane, Emmanuel C Opara
Islet transplantation (IT) has recently been shown to be a promising alternative to pancreas transplantation for reversing diabetes. IT requires the isolation of the islets from the pancreas, and these islets can be used to fabricate a bio-artificial pancreas. Enzymatic digestion is the current gold standard procedure for islet isolation but has lingering concerns. One such concern is that it has been shown to damage the islets due to nonselective tissue digestion. This chapter provides a detailed description of a nonenzymatic method that we are exploring in our lab as an alternative to current enzymatic digestion procedures for islet isolation from human and nonhuman pancreatic tissues...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27734723/glucose-archetypal-biomarker-in-diabetes-diagnosis-clinical-management-and-research
#11
Andrew J Krentz, Marcus Hompesch
The clinical utility of diabetes biomarkers can be considered in terms of diagnosis, management and prediction of long-term vascular complications. Glucose satisfies all of these requirements. Thresholds of hyperglycemia diagnostic of diabetes reflect inflections that confer a risk of developing long-term microvascular complications. Degrees of hyperglycemia (impaired fasting glucose, impaired glucose tolerance) that lie below the diagnostic threshold for diabetes identify individuals at risk of progression to diabetes and/or development of atherothrombotic cardiovascular disease...
October 13, 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27734563/heart-rate-informed-artificial-pancreas-system-enhances-glycemic-control-during-exercise-in-adolescents-with-t1d
#12
Mark D DeBoer, Daniel R Cherñavvsky, Katarina Topchyan, Boris P Kovatchev, Gary L Francis, Marc D Breton
OBJECTIVE: To evaluate the safety and performance of using a heart rate (HR) monitor to inform an artificial pancreas (AP) system during exercise among adolescents with type 1 diabetes (T1D). MATERIALS AND METHODS: In a randomized, cross-over trial, adolescents with T1D age 13 - 18 years were enrolled to receive on separate days either the unmodified UVa AP (stdAP) or an AP system connected to a portable HR monitor (AP-HR) that triggered an exercise algorithm for blood glucose (BG) control...
October 13, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27708324/a-mars-rocket-an-artificial-pancreas-and-a-plutonium-problem
#13
(no author information available yet)
No abstract text is available yet for this article.
October 5, 2016: Nature
https://www.readbyqxmd.com/read/27704875/physiology-invariant-meal-detection-for-type-1-diabetes
#14
James Weimer, Sanjian Chen, Amy Peleckis, Michael R Rickels, Insup Lee
BACKGROUND: Fully automated artificial pancreas systems require meal detectors to supplement blood glucose level regulation, where false meal detections can cause unnecessary insulin delivery with potentially fatal consequences, and missed detections may cause the patient to experience extreme hyperglycemia. Most existing meal detectors monitor various measures of glucose rate-of-change to detect meals where varying physiology and meal content complicate balancing detector sensitivity versus specificity...
October 5, 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27704167/efficacy-of-single-hormone-and-dual-hormone-artificial-pancreas-during-continuous-and-interval-exercise-in-adult-patients-with-type-1-diabetes-randomised-controlled-crossover-trial
#15
Nadine Taleb, Ali Emami, Corinne Suppere, Virginie Messier, Laurent Legault, Martin Ladouceur, Jean-Louis Chiasson, Ahmad Haidar, Rémi Rabasa-Lhoret
AIMS/HYPOTHESIS: The aim of this study was to assess whether the dual-hormone (insulin and glucagon) artificial pancreas reduces hypoglycaemia compared with the single-hormone (insulin alone) artificial pancreas during two types of exercise. METHODS: An open-label randomised crossover study comparing both systems in 17 adults with type 1 diabetes (age, 37.2 ± 13.6 years; HbA1c, 8.0 ± 1.0% [63.9 ± 10.2 mmol/mol]) during two exercise types on an ergocycle and matched for energy expenditure: continuous (60% [Formula: see text] for 60 min) and interval (2 min alternating periods at 85% and 50% [Formula: see text] for 40 min, with two 10 min periods at 45% [Formula: see text] at the start and end of the session)...
October 4, 2016: Diabetologia
https://www.readbyqxmd.com/read/27696520/psychological-outcomes-of-evening-and-night-closed-loop-insulin-delivery-under-free-living-conditions-in-people-with-type-1-diabetes-a-2-month-randomized-crossover-trial
#16
J Kropff, J DeJong, S Del Favero, J Place, M Messori, B Coestier, A Farret, F Boscari, S Galasso, A Avogaro, D Bruttomesso, C Cobelli, E Renard, L Magni, J H DeVries
AIM: To assess the impact on fear of hypoglycaemia and treatment satisfaction with an artificial pancreas system used for 2 consecutive months, as well as participant acceptance of the artificial pancreas system. METHODS: In a randomized crossover trial participant-related outcomes associated with an evening-and-night artificial pancreas and sensor-augmented pump therapy were compared. Both intervention periods lasted 8 weeks. The artificial pancreas acceptance questionnaire (range 0-90, higher scores better), Hypoglycaemia Fear Survey II (range 0-72, higher scores worse) and Diabetes Treatment Satisfaction Questionnaire (range 0-36, higher scores better) were completed by 32 participants...
October 1, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27695131/periodic-zone-mpc-with-asymmetric-costs-for-outpatient-ready-safety-of-an-artificial-pancreas-to-treat-type-1-diabetes
#17
Ravi Gondhalekar, Eyal Dassau, Francis J Doyle
A novel Model Predictive Control (MPC) law for an Artificial Pancreas (AP) to automatically deliver insulin to people with type 1 diabetes is proposed. The MPC law is an enhancement of the authors' zone-MPC approach that has successfully been trialled in-clinic, and targets the safe outpatient deployment of an AP. The MPC law controls blood-glucose levels to a diurnally time-dependent zone, and enforces diurnal, hard input constraints. The main algorithmic novelty is the use of asymmetric input costs in the MPC problem's objective function...
September 2016: Automatica: the Journal of IFAC, the International Federation of Automatic Control
https://www.readbyqxmd.com/read/27690486/psychology-technology-and-diabetes-management
#18
Linda A Gonder-Frederick, Jaclyn A Shepard, Jesse H Grabman, Lee M Ritterband
Use of technology in diabetes management is rapidly advancing and has the potential to help individuals with diabetes achieve optimal glycemic control. Over the past 40 years, several devices have been developed and refined, including the blood glucose meter, insulin pump, and continuous glucose monitor. When used in tandem, the insulin pump and continuous glucose monitor have prompted the Artificial Pancreas initiative, aimed at developing control system for fully automating glucose monitoring and insulin delivery...
October 2016: American Psychologist
https://www.readbyqxmd.com/read/27651347/comparison-between-a-novel-and-conventional-artificial-pancreas-for-perioperative-glycemic-control-using-a-closed-loop-system
#19
Tsutomu Namikawa, Masaya Munekage, Hiroyuki Kitagawa, Tomoaki Yatabe, Hiromichi Maeda, Yuuki Tsukamoto, Kenichi Hirano, Takuji Asano, Yoshihiko Kinoshita, Kazuhiro Hanazaki
This clinical study aimed to compare a novel and conventional artificial pancreas (AP) used in surgical patients for perioperative glycemic control, with respect to usability, blood glucose measurements, and glycemic control characteristics. From July in 2010 to March in 2015, 177 patients underwent perioperative glycemic control using a novel AP. Among them, 166 patients were eligible for inclusion in this study. Intensive insulin therapy (IIT) targeting a blood glucose range of 80-110 mg/dL was implemented in 82 patients (49 %), and the remaining 84 patients (51 %) received a less-intensive regime of insulin therapy...
September 20, 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/27629286/glucagon-in-artificial-pancreas-systems-potential-benefits-and-safety-profile-of-future-chronic-use
#20
REVIEW
Nadine Taleb, Ahmad Haidar, Virginie Messier, Véronique Gingras, Laurent Legault, Rémi Rabasa-Lhoret
The role of glucagon in the pathophysiology of diabetes has long been recognized, although its approved clinical use has so far been limited to the emergency treatment of severe hypoglycaemia. A novel use of glucagon as intermittent mini-boluses is proposed in the dual-hormone version (insulin and glucagon) of the external artificial pancreas. Short-term studies suggest that the incorporation of glucagon into artificial pancreas systems has the potential to further decrease hypoglycaemic risk and improve overall glucose control; however, the potential long-term safety and benefits also need to be investigated given the recognized systemic effects of glucagon...
September 15, 2016: Diabetes, Obesity & Metabolism
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