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Artificial pancreas

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https://www.readbyqxmd.com/read/29451021/the-uva-padova-type-1-diabetes-simulator-goes-from-single-meal-to-single-day
#1
Roberto Visentin, Enrique Campos-Náñez, Michele Schiavon, Dayu Lv, Martina Vettoretti, Marc Breton, Boris P Kovatchev, Chiara Dalla Man, Claudio Cobelli
BACKGROUND: A new version of the UVA/Padova Type 1 Diabetes (T1D) Simulator is presented which provides a more realistic testing scenario. The upgrades to the previous simulator, which was accepted by the Food and Drug Administration in 2013, are described. METHOD: Intraday variability of insulin sensitivity (S I ) has been modeled, based on clinical T1D data, accounting for both intra- and intersubject variability of daily S I . Thus, time-varying distributions of both subject's basal insulin infusion and insulin-to-carbohydrate ratio were calculated and made available to the user...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29446980/best-use-of-models-to-advance-the-artificial-pancreas
#2
Garry M Steil
No abstract text is available yet for this article.
February 15, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29446890/building-a-better-pancreas
#3
Andrew Curry
For years, an artificial pancreas was a pipe dream. Now, we're closer than ever to systems that will automatically adjust background insulin. Here's what's in the works--and what's still to come.
May 2017: Diabetes Forecast
https://www.readbyqxmd.com/read/29445834/the-combination-of-2-5-dihydroxybenzoic-acid-and-2-5-dihydroxyacetophenone-matrices-for-unequivocal-assignment-of-phosphatidylethanolamine-species-in-complex-mixtures
#4
Jenny Schröter, Annabelle Fülöp, Carsten Hopf, Jürgen Schiller
Unequivocal assignment of phospholipid peaks in complex mixtures is difficult if only the m/z values but no tandem mass spectrometry (MS/MS) data are available. This is usually the case for matrix-assisted laser/desorption ionization time-of-flight (MALDI-TOF) MS imaging experiments and the analysis has normally to be performed without prior separation. Another problem might be the often matrix-induced loss of one methyl group in phosphatidylcholine (PC) species, which makes them detectable as negative ions becoming isomers of some phosphatidylethanolamines (PEs)...
February 14, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29422651/impact-of-erroneous-meal-insulin-bolus-with-dual-hormone-artificial-pancreas-using-a-simplified-bolus-strategy-a-randomized-controlled-trial
#5
Véronique Gingras, Mohamed Raef Smaoui, Charlotte Cameli, Virginie Messier, Martin Ladouceur, Laurent Legault, Rémi Rabasa-Lhoret
Postprandial glucose control remains challenging for patients with type 1 diabetes (T1D). A simplified meal bolus approach with a dual-hormone (insulin and glucagon) closed-loop system (DH-CLS) has been tested; yet, the impact of categorization errors with this strategy is unknown. The objective was to compare, in a randomized controlled inpatient trial, DH-CLS with the simplified meal bolus approach for two different meals properly categorized or overestimated. We tested, in patients with T1D, the simplified strategy with two standardized breakfasts (n = 10 per meal) adequately categorized or overestimated: (1) 75 g and (2) 45 g of carbohydrate...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421420/continuous-blood-glucose-monitoring-may-detect-carotid-occlusion-intolerance-during-carotid-artery-stenting
#6
Ryo Hiramatsu, Motomasa Furuse, Ryokichi Yagi, Tomohisa Ohmura, Hiroyuki Ohnishi, Naokado Ikeda, Naosuke Nonoguchi, Shinji Kawabata, Shigeru Miyachi, Toshihiko Kuroiwa
BACKGROUND: The frequency of the occurrence of adverse events associated with carotid artery stenting (CAS) is usually low, but serious adverse events such as cerebral hyperperfusion syndrome (CHS) may occur. Real-time monitoring is ideal for the early detection of adverse events during the surgical procedure. This study aimed to evaluate continuous blood glucose (BG) monitoring for the detection of adverse events during CAS. METHODS: Forty patients undergoing scheduled CAS were prospectively enrolled...
February 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29412837/glucose-lowering-therapies-in-type-2-diabetes-opportunities-and-challenges-for-peptides
#7
REVIEW
Clifford J Bailey
This overview considers the opportunities and challenges that face the use of gluco-regulatory peptides to treat type 2 diabetes. New insulin analogues and formulations are being developed with pharmacokinetic properties to speed-up or prolong transfer from a subcutaneous injection site to the target tissues, or to selectively favour effects on the liver. Alternative routes of insulin administration continue to attract attention, and advances in the integration of glucose monitoring with insulin pump devices are improving miniaturised 'closed loop' artificial pancreas systems...
February 2018: Peptides
https://www.readbyqxmd.com/read/29406789/automatic-detection-and-estimation-of-unannounced-meals-for-multivariable-artificial-pancreas-system
#8
Sediqeh Samadi, Mudassir Rashid, Kamuran Turksoy, Jianyuan Feng, Iman Hajizadeh, Nicole Hobbs, Caterina Lazaro, Mert Sevil, Elizabeth Littlejohn, Ali Cinar
BACKGROUND: Automatically attenuating the postprandial rise in the blood glucose concentration without manual meal announcement is a significant challenge for artificial pancreas (AP) systems. In this study, a meal module is proposed to detect the consumption of a meal and to estimate the amount of carbohydrate (CHO) intake. METHODS: The meals are detected based on qualitative variables describing variation of continuous glucose monitoring (CGM) readings. The CHO content of the meals/snacks is estimated by a fuzzy system using CGM and subcutaneous insulin delivery data...
February 6, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29402368/-efficacy-and-safety-of-simulated-artificial-pancreas-in-modulating-stress-hyperglycemia-in-critically-ill-patients-a-prospective-randomized-controlled-study
#9
Zhongliang Yang, Guoqiang Tao, Meifeng Guo, Baoling Sun, Liang Gong, Yong Ding, Shuming Ye, Weidong Liu, Xiuyun Yang
OBJECTIVE: To explore efficacy and safety of simulated artificial pancreas in modulating stress hyperglycemia in critically ill patients. METHODS: A prospective randomized controlled study was performed. Seventy-two critically ill patients with stress hyperglycemia, aged 18-85 years, acute physiology and chronic health evaluation II (APACHE II) score over 15, two consecutive random blood glucose 11.1 mmol/L or higher, glycated hemoglobin (HbA1C) below 0.065, unable to eat food for 3 days after inclusion, or only accepting parenteral nutrition, admitted to intensive care unit (ICU) in Shanghai Punan Hospital of Pudong New District from January 1st, 2015 to June 30th, 2017 were enrolled...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29393675/overnight-glucose-control-with-dual-and-single-hormone-artificial-pancreas-in-type-1-diabetes-with-hypoglycemia-unawareness-a-randomized-controlled-trial
#10
Alexander Abitbol, Remi Rabasa-Lhoret, Virginie Messier, Laurent Legault, Mohamad Smaoui, Nathan Cohen, Ahmad Haidar
BACKGROUND: The dual-hormone (insulin and glucagon) artificial pancreas may be justifiable in some, but not all, patients. We sought to compare dual- and single-hormone artificial pancreas systems in patients with hypoglycemia unawareness and documented nocturnal hypoglycemia. METHODS: We conducted a randomized crossover trial comparing the efficacy of dual- and single-hormone artificial pancreas systems in controlling plasma glucose levels over the course of one night's sleep...
February 2, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29390915/real-time-detection-of-infusion-site-failures-in-a-closed-loop-artificial-pancreas
#11
Daniel P Howsmon, Nihat Baysal, Bruce A Buckingham, Gregory P Forlenza, Trang T Ly, David M Maahs, Tatiana Marcal, Lindsey Towers, Eric Mauritzen, Sunil Deshpande, Lauren M Huyett, Jordan E Pinsker, Ravi Gondhalekar, Francis J Doyle, Eyal Dassau, Juergen Hahn, B Wayne Bequette
BACKGROUND: As evidence emerges that artificial pancreas systems improve clinical outcomes for patients with type 1 diabetes, the burden of this disease will hopefully begin to be alleviated for many patients and caregivers. However, reliance on automated insulin delivery potentially means patients will be slower to act when devices stop functioning appropriately. One such scenario involves an insulin infusion site failure, where the insulin that is recorded as delivered fails to affect the patient's glucose as expected...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29383544/emerging-technologies-for-the-management-of-type-1-diabetes-in-pregnancy
#12
REVIEW
Jennifer M Yamamoto, Helen R Murphy
PURPOSE OF REVIEW: The purpose of the study is to discuss emerging technologies available in the management of type 1 diabetes in pregnancy. RECENT FINDINGS: The latest evidence suggests that continuous glucose monitoring (CGM) should be offered to all women on intensive insulin therapy in early pregnancy. Studies have additionally demonstrated the ability of CGM to help gain insight into specific glucose profiles as they relate to glycaemic targets and pregnancy outcomes...
January 30, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29359558/insulin-detection-using-a-corona-phase-molecular-recognition-site-on-single-walled-carbon-nanotubes
#13
Gili Bisker, Naveed Ali Bakh, Michael A Lee, Jiyoung Ahn, Minkyung Park, Ellen B O'Connell, Nicole Iverson, Michael S Strano
Corona Phase Molecular Recognition (CoPhMoRe) is a technique whereby an external, adsorbed phase around a colloidal nanoparticle is selected such that its molecular conformation or interaction recognizes a specific target analyte. In this work, we employ a high-throughput screening of a library of poly(ethylene glycol) (PEG)-conjugated lipids adsorbed onto near-infrared fluorescent single-walled carbon nanotubes to discover a corona phase selective for insulin. We find that a C16-PEG(2000kDa)-Ceramide causes a 62% fluorescent intensity decrease of the (10,2) chirality nanotube in 20 µg/ml insulin concentration...
January 23, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29356912/current-status-and-issues-of-the-artificial-pancreas-abridged-english-translation-of-a-special-issue-in-japanese
#14
REVIEW
Tsutomu Namikawa, Masaya Munekage, Tomoaki Yatabe, Hiroyuki Kitagawa, Kazuhiro Hanazaki
Surgical stress induces hyperglycemia and gives rise to glucose toxicity, which causes infectious diseases, resulting in unfavorable surgical outcomes. Intensive insulin treatment can control short- and long-term complications in patients with not only diabetes mellitus, but also surgical diabetes; however, it is associated with an increased risk of hypoglycemia. The wearable artificial pancreas was originally developed to control glucose levels in patients with type 1 diabetes, progressing to a device with enhanced stability and safety for these patients...
January 22, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29337384/dual-hormone-artificial-pancreas-benefits-and-limitations-compared-with-single-hormone-systems
#15
Tricia M Peters, Ahmad Haidar
Technological advances have made the artificial pancreas a reality. This has the potential to improve the lives of individuals with Type 1 diabetes by reducing the risk of hypoglycaemia, achieving better overall glucose control, and enhancing quality of life. Both single-hormone (insulin-only) and dual-hormone (insulin and glucagon) systems have been developed; however, a focused review of the relative benefits of each artificial pancreas system is needed. We reviewed studies that directly compared single- and dual-hormone systems to evaluate the efficacy of each system for preventing hypoglycaemia and maintaining glycaemic control, as well as their utility in specific situations including during exercise, overnight and during the prandial period...
January 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29320885/a-pilot-study-validating-select-research-grade-and-consumer-based-wearables-throughout-a-range-of-dynamic-exercise-intensities-in-persons-with-and-without-type-1-diabetes-a-novel-approach
#16
Loren Yavelberg, Dessi Zaharieva, Ali Cinar, Michael C Riddell, Veronica Jamnik
BACKGROUND: The increasing popularity of wearable technology necessitates the evaluation of their accuracy to differentiate physical activity (PA) intensities. These devices may play an integral role in customizing PA interventions for primary prevention and secondary management of chronic diseases. For example, in persons with type 1 diabetes (T1D), PA greatly affects glucose concentrations depending on the intensity, mode (ie, aerobic, anaerobic, mixed), and duration. This variability in glucose responses underscores the importance of implementing dependable wearable technology in emerging avenues such as artificial pancreas systems...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29286043/the-artificial-pancreas-in-2017-the-year-of-transition-from-research-to-clinical-practice
#17
Boris Kovatchev
No abstract text is available yet for this article.
December 22, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29279252/automated-blood-glucose-control-in-type-1-diabetes-a-review-of-progress-and-challenges
#18
Arthur Bertachi, Charrise M Ramkissoon, Jorge Bondia, Josep Vehí
Since the 2000s, research teams worldwide have been working to develop closed-loop (CL) systems able to automatically control blood glucose (BG) levels in patients with type 1 diabetes. This emerging technology is known as artificial pancreas (AP), and its first commercial version just arrived in the market. The main objective of this paper is to present an extensive review of the clinical trials conducted since 2011, which tested various implementations of the AP for different durations under varying conditions...
December 24, 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29276347/model-fusion-based-online-glucose-concentration-predictions-in-people-with-type-1-diabetes
#19
Xia Yu, Kamuran Turksoy, Mudassir Rashid, Jianyuan Feng, Nicole Frantz, Iman Hajizadeh, Sediqeh Samadi, Mert Sevil, Caterina Lazaro, Zacharie Maloney, Elizabeth Littlejohn, Laurie Quinn, Ali Cinar
Accurate predictions of glucose concentrations are necessary to develop an artificial pancreas (AP) system for people with type 1 diabetes (T1D). In this work, a novel glucose forecasting paradigm based on a model fusion strategy is developed to accurately characterize the variability and transient dynamics of glycemic measurements. To this end, four different adaptive filters and a fusion mechanism are proposed for use in the online prediction of future glucose trajectories. The filter fusion mechanism is developed based on various prediction performance indexes to guide the overall output of the forecasting paradigm...
February 2018: Control Engineering Practice
https://www.readbyqxmd.com/read/29258910/glucose-responsive-insulin-delivery-for-type-1-diabetes-the-artificial-pancreas-story
#20
Lia Bally, Hood Thabit, Roman Hovorka
Insulin replacement therapy is integral to the management of type 1 diabetes, which is characterised by absolute insulin deficiency. Optimal glycaemic control, as assessed by glycated haemoglobin, and avoidance of hyper- and hypoglycaemic excursions have been shown to prevent diabetes-related complications. Insulin pump use has increased considerably over the past decade with beneficial effects on glycaemic control, quality of life and treatment satisfaction. The advent and progress of ambulatory glucose sensor technology has enabled continuous glucose monitoring based on real-time glucose levels to be integrated with insulin therapy...
December 16, 2017: International Journal of Pharmaceutics
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