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https://www.readbyqxmd.com/read/27831760/suppression-of-hbxip-reduces-cell-proliferation-migration-and-invasion-in-vitro-and-tumorigenesis-in-vivo-in-human-urothelial-carcinoma-of-the-bladder
#1
Xiaogang Li, Shuangping Liu
Hepatitis B X-interacting protein (HBXIP) has been found overexpressed in several types of human cancer, however, the status of HBXIP expression in urothelial carcinoma of the bladder (UCB) has not been explored. In this study, the authors used real-time polymerase chain reaction and Western blot to test the expression of HBXIP in UCB and adjacent tissues. The expression of HBXIP was significantly increased in UCB tissues. In addition, they showed that suppression of HBXIP induced cell cycle arrest and increased cell apoptosis in T24 cells...
November 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27765671/the-oncoprotein-hbxip-up-regulates-yap-through-activation-of-transcription-factor-c-myb-to-promote-growth-of-liver-cancer
#2
Yue Wang, Runping Fang, Ming Cui, Weiying Zhang, Xiao Bai, Huawei Wang, Bowen Liu, Xiaodong Zhang, Lihong Ye
The oncoprotein Yes-associated protein (YAP) in Hippo pathway plays crucial roles in the development of cancer. However, the mechanism of YAP regulation in cancer remains poorly understood. Here, we supposed that the oncoprotein hepatitis B X-interacting protein (HBXIP) might be involved in the modulation of YAP in liver cancer. Interestingly, our data showed that the expression levels of HBXIP were positively associated with those of YAP in clinical hepatocellular carcinoma (HCC) samples by immunohistochemistry (IHC) staining and real-time PCR assays...
January 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27609066/the-oncoprotein-hbxip-suppresses-gluconeogenesis-through-modulating-pck1-to-enhance-the-growth-of-hepatoma-cells
#3
Hui Shi, Runping Fang, Yinghui Li, Leilei Li, Weiying Zhang, Huawei Wang, Fuquan Chen, Shuqin Zhang, Xiaodong Zhang, Lihong Ye
Hepatitis B X-interacting protein (HBXIP) as an oncoprotein plays crucial roles in the development of cancer, involving glucose metabolism reprogramming. In this study, we are interested in whether the oncoprotein HBXIP is involved in the modulation of gluconeogenesis in liver cancer. Here, we showed that the expression level of phosphoenolpyruvate carboxykinase (PCK1), a key enzyme of gluconeogenesis, was lower in clinical hepatocellular carcinoma (HCC) tissues than that in normal tissues. Mechanistically, HBXIP inhibited the expression of PCK1 through down-regulating transcription factor FOXO1 in hepatoma cells, and up-regulated miR-135a targeting the 3'UTR of FOXO1 mRNA in the cells...
September 5, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27068521/the-hevea-brasiliensis-xip-aquaporin-subfamily-genomic-structural-and-functional-characterizations-with-relevance-to-intensive-latex-harvesting
#4
David Lopez, Maroua Ben Amira, Daniel Brown, Beatriz Muries, Nicole Brunel-Michac, Sylvain Bourgerie, Benoit Porcheron, Remi Lemoine, Hervé Chrestin, Ewan Mollison, Alessandra Di Cola, Lorenzo Frigerio, Jean-Louis Julien, Aurélie Gousset-Dupont, Boris Fumanal, Philippe Label, Valérie Pujade-Renaud, Daniel Auguin, Jean-Stéphane Venisse
X-Intrinsic Proteins (XIP) were recently identified in a narrow range of plants as a full clade within the aquaporins. These channels reportedly facilitate the transport of a wide range of hydrophobic solutes. The functional roles of XIP in planta remain poorly identified. In this study, we found three XIP genes (HbXIP1;1, HbXIP2;1 and HbXIP3;1) in the Hevea brasiliensis genome. Comprehensive bioinformatics, biochemical and structural analyses were used to acquire a better understanding of this AQP subfamily...
July 2016: Plant Molecular Biology
https://www.readbyqxmd.com/read/26980761/oncoprotein-hbxip-modulates-abnormal-lipid-metabolism-and-growth-of-breast-cancer-cells-by-activating-the-lxrs-srebp-1c-fas-signaling-cascade
#5
Yu Zhao, Hang Li, Yingyi Zhang, Leilei Li, Runping Fang, Yinghui Li, Qian Liu, Weiying Zhang, Liyan Qiu, Fabao Liu, Xiaodong Zhang, Lihong Ye
Abnormal lipid metabolism is a hallmark of tumorigenesis. Accumulating evidence demonstrates that fatty acid synthase (FAS, FASN) is a metabolic oncogene that supports the growth and survival of tumor cells and is highly expressed in many cancers. Here, we report that the oncoprotein, hepatitis B X-interacting protein (HBXIP, LAMTOR5) contributes to abnormal lipid metabolism. We show that high expression of HBXIP in 236 breast cancer patients was significantly associated with decreased overall survival and progression-free survival...
August 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/26828265/the-oncoprotein-hbxip-up-regulates-fgf4-through-activating-transcriptional-factor-sp1-to-promote-the-migration-of-breast-cancer-cells
#6
Hui Shi, Yinghui Li, Guoxing Feng, Leilei Li, Runping Fang, Zhen Wang, Jie Qu, Peijian Ding, Xiaodong Zhang, Lihong Ye
We have reported that the oncoprotein hepatitis B X-interacting protein (HBXIP) is able to promote migration of breast cancer cells. Fibroblast growth factor 4 (FGF4) is a multipotent growth factor and is highly expressed in various human cancers. However, the regulatory mechanism of FGF4 in breast cancer remains poorly understood. In the present study, we report that HBXIP is able to up-regulate FGF4 to enhance the migration of breast cancer cells. Immunohistochemistry staining showed that HBXIP and FGF4 were highly expressed in clinical metastatic lymph nodes of breast tumor...
February 26, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26657153/deacetylation-of-tumor-suppressor-mst1-in-hippo-pathway-induces-its-degradation-through-hbxip-elevated-hdac6-in-promotion-of-breast-cancer-growth
#7
L Li, R Fang, B Liu, H Shi, Y Wang, W Zhang, X Zhang, L Ye
Reduction or loss of tumor-suppressor mammalian STE20-like kinase 1 (MST1) in Hippo pathway contributes to the tumorigenesis. However, the mechanism leading to reduction of MST1 in cancers remains poorly understood. In this study, we explored the hypothesis that the oncoprotein hepatitis B X-interacting protein (HBXIP) is involved in the reduction of MST1 in breast cancer. Immunohistochemical analysis of tissue microarrays revealed that the expression of HBXIP was negatively associated with that of MST1 in 98 clinical breast tissue samples...
August 4, 2016: Oncogene
https://www.readbyqxmd.com/read/26583881/mirna-548p-suppresses-hepatitis-b-virus-x-protein-associated-hepatocellular-carcinoma-by-downregulating-oncoprotein-hepatitis-b-x-interacting-protein
#8
Xiu-Mei Hu, Xiao-Hui Yan, Yan-Wei Hu, Jin-Lan Huang, Shun-Wang Cao, Ting-Yu Ren, Yue-Ting Tang, Li Lin, Lei Zheng, Qian Wang
AIM: miR-548p is a recently identified and poorly characterized miRNA. However, its role of miR-548p in tumorigenesis and progression remains poorly understood. Here, we aimed to investigate the biofunction of miR-548p in hepatocellular carcinogenesis. METHODS: The expression levels of miR-548p were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The role of miR-548p in hepatocellular carcinoma (HCC) was determined by colony formation, flow cytometry assay and nude mice xenograft experiments...
July 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/26309161/the-oncoprotein-hbxip-promotes-glucose-metabolism-reprogramming-via-downregulating-sco2-and-pdha1-in-breast-cancer
#9
Fabao Liu, Weiying Zhang, Xiaona You, Yunxia Liu, Yinghui Li, Zhen Wang, Yue Wang, Xiaodong Zhang, Lihong Ye
The glucose metabolism reprogramming is a hallmark of cancer. The oncoprotein hepatitis B X-interacting protein (HBXIP) functions in the development of breast cancer. In this study, we supposed that HBXIP might be involved in the glucose metabolism reprogramming in breast cancer. We showed that HBXIP led to increases in generation of intracellular glucose and lactate, as well as decreases in generation of reactive oxygen species. Expression of synthesis of cytochrome c oxidase 2 (SCO2) and pyruvate dehydrogenase alpha 1 (PDHA1), two factors of metabolic switch from oxidative phosphorylation to aerobic glycolysis, was suppressed by HBXIP...
September 29, 2015: Oncotarget
https://www.readbyqxmd.com/read/26229107/the-oncoprotein-hbxip-modulates-the-feedback-loop-of-mdm2-p53-to-enhance-the-growth-of-breast-cancer
#10
Hang Li, Qian Liu, Zhen Wang, Runping Fang, Yu Shen, Xiaoli Cai, Yuen Gao, Yinghui Li, Xiaodong Zhang, Lihong Ye
MDM2 and p53 form a negative feedback loop, in which p53 as a transcription factor positively regulates MDM2 and MDM2 negatively regulates tumor suppressor p53 through promoting its degradation. However, the mechanism of the feedback loop is poorly understood in cancers. We had reported previously that the oncoprotein hepatitis B X-interacting protein (HBXIP) is a key oncoprotein in the development of cancer. Thus, we supposed that HBXIP might be involved in the event. Here, we observed that the expression levels of HBXIP were positively correlated to those of MDM2 in clinical breast cancer tissues...
September 11, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25686500/the-oncoprotein-hbxip-promotes-migration-of-breast-cancer-cells-via-gcn5-mediated-microtubule-acetylation
#11
Leilei Li, Bowen Liu, Xiaodong Zhang, Lihong Ye
We have documented that the oncoprotein hepatitis B X-interacting protein (HBXIP) is able to promote migration of breast cancer cells. A subset of acetylated microtubules that accumulates in the cell leading edge is necessary for cell polarization and directional migration. In this study, we explored the hypothesis that HBXIP contributes to migration of breast cancer cells by supporting microtubule acetylation in breast cancer cells. We found that HBXIP could induce acetylated microtubules accumulating into the leading protrusion in wound-induced directional migration in breast cancer cells by immunofluorescence staining analysis...
March 13, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25304384/the-oncoprotein-hbxip-enhances-migration-of-breast-cancer-cells-through-increasing-filopodia-formation-involving-mekk2-erk1-2-capn4-signaling
#12
Yinghui Li, Zhao Zhang, Xiaolei Zhou, Leilei Li, Qian Liu, Zhen Wang, Xiao Bai, Yu Zhao, Hui Shi, Xiaodong Zhang, Lihong Ye
We have reported that the oncoprotein hepatitis B X-interacting protein (HBXIP) plays a crucial role in the promotion of migration of breast cancer cells. Lamellipodia and filopodia protrusions play fundamental roles, involving dynamic cytoskeleton reorganization in the metastasis of cancer. Here, we observed that the expression levels of both HBXIP and Calpain small subunit 1 (Capn4) were very high in clinical metastatic lymph nodes of breast tumor. Then, we found that HBXIP was able to up-regulate Capn4 at the levels of promoter, mRNA and protein in breast cancer cells through activation of ERK1/2...
December 28, 2014: Cancer Letters
https://www.readbyqxmd.com/read/25178941/hbxip-expression-predicts-patient-prognosis-in-breast-cancer
#13
Daye Cheng, Bin Liang, Yunhui Li
Emerging evidence demonstrated that hepatitis B virus X-interacting protein (HBXIP) has broad roles in cancers. The aim of the study is to investigate the association between HBXIP expression and clinicopathological features of breast cancer patients so as to determine whether HBXIP protein may be correlated with poor prognosis in breast cancer patients. HBXIP protein expression was assessed in a well-characterized series of breast cancer (n=196) with long-term follow-up, using immunohistochemistry method. Correlation between HBXIP expression and clinicopathological factors was analyzed...
October 2014: Medical Oncology
https://www.readbyqxmd.com/read/24886421/hepatitis-b-virus-x-protein-accelerates-hepatocarcinogenesis-with-partner-survivin-through-modulating-mir-520b-and-hbxip
#14
Weiying Zhang, Zhanping Lu, Guangyao Kong, Yuen Gao, Tao Wang, Qi Wang, Na Cai, Honghui Wang, Fabao Liu, Lihong Ye, Xiaodong Zhang
BACKGROUND: Hepatitis B virus X protein (HBx) plays crucial roles in hepatocarcinogenesis. However, the underlying mechanism remains elusive. We have reported that HBx is able to up-regulate survivin in hepatocellular carcinoma tissues. The oncopreotein hepatitis B X-interacting protein (HBXIP), a target of miR-520b, is involved in the development of cancer. In this study, we focus on the investigation of hepatocarcinogenesis mediated by HBx. METHODS: The expression of HBx and survivin was examined in the liver tissues of HBx-Tg mice...
2014: Molecular Cancer
https://www.readbyqxmd.com/read/24882622/the-oncoprotein-hbxip-up-regulates-scg3-through-modulating-e2f1-and-mir-509-3p-in-hepatoma-cells
#15
Yue Wang, Ming Cui, Xiaoli Cai, Baodi Sun, Fabao Liu, Xiaodong Zhang, Lihong Ye
Hepatitis B X-interacting protein (HBXIP) is an important oncoprotein in hepatocarcinogenesis. Here, we found that the expression levels of HBXIP were positively associated with those of Secretogranin III (SCG3) in clinical hepatocellular carcinoma tissues. We identified that HBXIP up-regulated the expression of SCG3 through modulating both E2F transcription factor 1 (E2F1) and miR-509-3p. HBXIP suppressed miR-509-3p through activating NF-κB. In function, we showed that SCG3 increased the proliferation of hepatoma cells and HBXIP enhanced the proliferation of the cells via SCG3 in vitro and in vivo...
October 1, 2014: Cancer Letters
https://www.readbyqxmd.com/read/24788380/the-oncoprotein-hepatitis-b-x-interacting-protein-promotes-the-migration-of-ovarian-cancer-cells-through-the-upregulation-of-s-phase-kinase-associated-protein-2-by-sp1
#16
Fuqiang Xu, Xiaoming Zhu, Tao Han, Xiaona You, Fabao Liu, Lihong Ye, Xiaodong Zhang, Xiaohong Wang, Yuanqing Yao
Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein. We have previously reported that HBXIP promotes the proliferation and migration of breast cancer cells. S-phase kinase-associated protein 2 (Skp2) is another oncoprotein which is important for migration. In this study, we investigated whether Skp2 is involved in the migration enhanced by HBXIP in ovarian cancer. The expression of HBXIP and Skp2 in ovarian cancer tissues was examined by immunohistochemistry using tissue microarrays. The role of HBXIP and Skp2 in the migration of ovarian cancer cells was investigated by wound-healing assay and Transwell migration assay...
July 2014: International Journal of Oncology
https://www.readbyqxmd.com/read/24464787/the-oncoprotein-hbxip-enhances-angiogenesis-and-growth-of-breast-cancer-through-modulating-fgf8-and-vegf
#17
Fabao Liu, Xiaona You, Yue Wang, Qian Liu, Yunxia Liu, Shuqin Zhang, Lingyi Chen, Xiaodong Zhang, Lihong Ye
Tumor angiogenesis plays an important role in the development of cancer. Previously, we reported that hepatitis B X-interacting protein (HBXIP) functioned as an oncoprotein in breast cancer. However, the role of HBXIP in angiogenesis in breast cancer remains poorly understood. In the present study, we show that the oncoprotein HBXIP plays crucial roles in the event. We observed that the expression levels of HBXIP were positively correlated with those of fibroblast growth factor 8 (FGF8) or vascular endothelial growth factor (VEGF) in clinical breast cancer tissues...
May 2014: Carcinogenesis
https://www.readbyqxmd.com/read/24377928/p18-lamtor1-a-late-endosome-lysosome-specific-anchor-protein-for-the-mtorc1-mapk-signaling-pathway
#18
Shigeyuki Nada, Shunsuke Mori, Yusuke Takahashi, Masato Okada
p18/LAMTOR1 is a membrane protein specifically localized to the surface of late endosomes/lysosomes that serves as an anchor for the "Ragulator" complex, which contains p14/LAMTOR2, MP1/LAMTOR3, HBXIP, and C7orf59. The Ragulator interacts with RagAB/CD GTPases and V-ATPase and plays crucial roles for activation of mammalian target of rapamycin complex 1 (mTORC1) on the lysosomal surface. Activated mTORC1 orchestrates various cellular functions, for example, macromolecule biosynthesis, energy metabolism, autophagy, cell growth, responses to growth factors, and the trafficking and maturation of lysosomes...
2014: Methods in Enzymology
https://www.readbyqxmd.com/read/24098497/concurrent-gene-signatures-for-han-chinese-breast-cancers
#19
Chi-Cheng Huang, Shih-Hsin Tu, Heng-Hui Lien, Jaan-Yeh Jeng, Ching-Shui Huang, Chi-Jung Huang, Liang-Chuan Lai, Eric Y Chuang
The interplay between copy number variation (CNV) and differential gene expression may be able to shed light on molecular process underlying breast cancer and lead to the discovery of cancer-related genes. In the current study, genes concurrently identified in array comparative genomic hybridization (CGH) and gene expression microarrays were used to derive gene signatures for Han Chinese breast cancers. We performed 23 array CGHs and 81 gene expression microarrays in breast cancer samples from Taiwanese women...
2013: PloS One
https://www.readbyqxmd.com/read/23667255/the-nuclear-import-of-oncoprotein-hepatitis-b-x-interacting-protein-depends-on-interacting-with-c-fos-and-phosphorylation-of-both-proteins-in-breast-cancer-cells
#20
Yingyi Zhang, Yu Zhao, Hang Li, Yinghui Li, Xiaoli Cai, Yu Shen, Hui Shi, Leilei Li, Qian Liu, Xiaodong Zhang, Lihong Ye
Aberrant nuclear localization of oncogenic transcription factors and coactivators always leads to the development of cancer. We have reported that the oncoprotein hepatitis B X-interacting protein (HBXIP) acts as a novel transcriptional coactivator to promote proliferation and migration of breast cancer cells. However, the mechanism of regulating the nuclear import of HBXIP remains unclear. In the present study, we found that HBXIP interacted with c-Fos through their leucine zipper domains in vitro and in vivo...
June 28, 2013: Journal of Biological Chemistry
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