keyword
https://read.qxmd.com/read/38543768/the-mytilus-chilensis-steamer-like-element-1-retrotransposon-antisense-mrna-harbors-an-internal-ribosome-entry-site-that-is-modulated-by-hnrnpk
#1
JOURNAL ARTICLE
Leandro Fernández-García, Constanza Ahumada-Marchant, Pablo Lobos-Ávila, Bastián Brauer, Fernando J Bustos, Gloria Arriagada
LTR-retrotransposons are transposable elements characterized by the presence of long terminal repeats (LTRs) directly flanking an internal coding region. They share genome organization and replication strategies with retroviruses. Steamer-like Element-1 ( Mch SLE-1) is an LTR-retrotransposon identified in the genome of the Chilean blue mussel Mytilus chilensis . Mch SLE-1 is transcribed; however, whether its RNA is also translated and the mechanism underlying such translation remain to be elucidated. Here, we characterize the Mch SLE-1 translation mechanism...
March 5, 2024: Viruses
https://read.qxmd.com/read/38542224/mitochondrial-ribosomal-protein-mrps15-is-a-component-of-cytosolic-ribosomes-and-regulates-translation-in-stressed-cardiomyocytes
#2
JOURNAL ARTICLE
Florian David, Emilie Roussel, Carine Froment, Tangra Draia-Nicolau, Françoise Pujol, Odile Burlet-Schiltz, Anthony K Henras, Eric Lacazette, Florent Morfoisse, Florence Tatin, Jean-Jacques Diaz, Frédéric Catez, Barbara Garmy-Susini, Anne-Catherine Prats
Regulation of mRNA translation is a crucial step in controlling gene expression in stressed cells, impacting many pathologies, including heart ischemia. In recent years, ribosome heterogeneity has emerged as a key control mechanism driving the translation of subsets of mRNAs. In this study, we investigated variations in ribosome composition in human cardiomyocytes subjected to endoplasmic reticulum stress induced by tunicamycin treatment. Our findings demonstrate that this stress inhibits global translation in cardiomyocytes while activating internal ribosome entry site (IRES)-dependent translation...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38538536/dusp3-modulates-ires-dependent-translation-of-mrnas-through-dephosphorylation-of-the-hnrnpc-protein-in-cells-under-genotoxic-stimulus
#3
JOURNAL ARTICLE
Pault Y M Ferruzo, Viktor K Boell, Lilian C Russo, Carla C Oliveira, Fabio L Forti
BACKGROUND INFORMATION: The dual-specificity phosphatase 3 (DUSP3) regulates cell cycle progression, proliferation, senescence, and DNA repair pathways under genotoxic stress. This phosphatase interacts with HNRNPC protein suggesting an involvement in the regulation of HNRNPC-ribonucleoprotein complex stability. In this work, we investigate the impact of DUSP3 depletion on functions of HNRNPC aiming to suggest new roles for this enzyme. RESULTS: The DUSP3 knockdown results in the tyrosine hyperphosphorylation state of HNRNPC increasing its RNA binding ability...
March 27, 2024: Biology of the Cell
https://read.qxmd.com/read/38531818/inhibition-of-the-endoplasmic-reticulum-stress-associated-ire-1-pathway-alleviates-preterm-birth
#4
JOURNAL ARTICLE
Liyin Qiu, Hui Liu, Shali Chen, Yiting Wu, Jianying Yan
BACKGROUND: Premature birth (PTB) remains a major global health concern due to its association with neonatal morbidity and mortality. The unfolded protein response (UPR) within the endoplasmic reticulum (ER) is tightly regulated by Inositol-requiring enzyme type 1 (IRE-1), a pivotal cellular modulator. This study seeks to elucidate the role of the ER stress (ERS)-related IRE-1 pathway in PTB. METHODS: Human placental trophoblast cells HTR8/Svneo were exposed to the ER-stress inducer tunicamycin (TM)...
March 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38520404/correction-to-hnrnp-a1-binds-to-the-ires-of-meloe-1-antigen-to-promote-meloe-1-translation-in-stressed-melanoma-cells
#5
(no author information available yet)
No abstract text is available yet for this article.
March 23, 2024: Molecular Oncology
https://read.qxmd.com/read/38513736/pulse-field-ablation-a-promising-approach-for-ventricular-tachycardia-ablation
#6
REVIEW
Zixi Zhang, Yichao Xiao, Cancan Wang, Jiabao Zhou, Qiuzhen Lin, Tao Tu, Keke Wu, Yunying Huang, Zeying Zhang, Chan Liu, Qiming Liu
Radiofrequency ablation (RFA) has been a central therapeutic strategy for ventricular tachycardia (VT). However, concerns about its long-term effectiveness and complications have arisen. Pulse field ablation (PFA), characterized by its nonthermal, highly tissue-selective ablation technique, has emerged as a promising alternative. This comprehensive review delves into the potential advantages and opportunities presented by PFA in the realm of VT, drawing insights from both animal experimentation and clinical case studies...
March 19, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38505483/international-evaluation-of-an-artificial-intelligence-powered-electrocardiogram-model-detecting-acute-coronary-occlusion-myocardial-infarction
#7
JOURNAL ARTICLE
Robert Herman, Harvey Pendell Meyers, Stephen W Smith, Dario T Bertolone, Attilio Leone, Konstantinos Bermpeis, Michele M Viscusi, Marta Belmonte, Anthony Demolder, Vladimir Boza, Boris Vavrik, Viera Kresnakova, Andrej Iring, Michal Martonak, Jakub Bahyl, Timea Kisova, Dan Schelfaut, Marc Vanderheyden, Leor Perl, Emre K Aslanger, Robert Hatala, Wojtek Wojakowski, Jozef Bartunek, Emanuele Barbato
AIMS: A majority of acute coronary syndromes (ACS) present without typical ST elevation. One-third of non-ST-elevation myocardial infarction (NSTEMI) patients have an acutely occluded culprit coronary artery [occlusion myocardial infarction (OMI)], leading to poor outcomes due to delayed identification and invasive management. In this study, we sought to develop a versatile artificial intelligence (AI) model detecting acute OMI on single-standard 12-lead electrocardiograms (ECGs) and compare its performance with existing state-of-the-art diagnostic criteria...
March 2024: European heart journal. Digital health
https://read.qxmd.com/read/38501662/biochemical-analysis-of-the-host-factor-activity-of-zcchc14-in-hepatitis-a-virus-replication
#8
JOURNAL ARTICLE
You Li, Stanley M Lemon
Relatively little is known of the mechanisms underlying hepatitis A virus (HAV) genome replication. Unlike other well-studied picornaviruses, HAV RNA replication requires the zinc finger protein ZCCHC14 and non-canonical TENT4 poly(A) polymerases with which it forms a complex. The ZCCHC14-TENT4 complex binds to a stem-loop located within the internal ribosome entry site (IRES) in the 5' untranslated RNA (5'UTR) and is essential for viral RNA synthesis, but the underlying mechanism is unknown. Here, we describe how different ZCCHC14 domains contribute to its RNA-binding, TENT4-binding, and HAV host factor activities...
March 19, 2024: Journal of Virology
https://read.qxmd.com/read/38500957/translation-of-circular-rnas-functions-of-translated-products-and-related-bioinformatics-approaches
#9
JOURNAL ARTICLE
Jae Yeon Hwang, Tae Lim Kook, Sydney M Paulus, Juw Won Park
Over the past two decades, studies have discovered a special form of alternative splicing (AS) that produces a circular form of RNA. This stands in contrast to normal AS, which produces a linear form of RNA. Although these circRNAs have garnered considerable attention in the scientific community for their biogenesis and functions, the focus of these studies has been on the regulatory role of circRNAs with the assumption that circRNAs are non-coding. As non-coding RNAs, they may regulate mRNA transcription, tumor initiation, and translation by sponging miRNAs and RNA-binding proteins (RBPs)...
2024: Current Bioinformatics
https://read.qxmd.com/read/38495485/threatment-strategies-for-recurrent-hepatocellular-carcinoma-patients-ablation-and-its-combination-patterns
#10
REVIEW
Ya'ning Zhao, Jun Bai, Xi Wang, Yaoren Zhang, Xiaohong Yan, Jun'an Qi, Xueyan Xia, Yuansong Feng, Baojun Duan
With the development of guidance technology and ablation equipment, ablative procedures have emerged as important loco-regional alternatives to surgical resection for recurrent hepatocellular carcinoma (rHCC) patients. Currently, ablation modalities used in clinical practice mainly include radiofrequency ablation (RFA), microwave ablation (MWA), laser ablation (LA), cryoablation (CRA), high-intensity focused ultrasound (HIFU), and irreversible electroporation (IRE). Accumulated comparative data of ablation versus surgical resection reveal noninferior responses and outcomes but superior adverse effects...
2024: Journal of Cancer
https://read.qxmd.com/read/38494526/irreversible-electroporation-to-bring-initially-unresectable-locally-advanced-pancreatic-adenocarcinoma-to-surgery-the-irecap-phase-ii-study
#11
JOURNAL ARTICLE
Jean-Pierre Tasu, Guillaume Herpe, Jérôme Damion, Jean-Pierre Richer, Bertrand Debeane, Mathilde Vionnet, Laetitia Rouleau, Michel Carretier, Aurélie Ferru, Pierre Ingrand, David Tougeron
OBJECTIVES: The aim of the IRECAP study was to evaluate the rate of locally advanced pancreas cancer patients (LAPC) who could undergo R0 or R1 surgery after irreversible electroporation (IRE). MATERIALS AND METHODS: IRECAP study is a phase II, single-center, open-label, prospective, non-randomized trial registered at clinicaltrials.gov (NCT03105921). Patients with LAPC were first treated by 3-month neo-adjuvant chemotherapy in order to avoid inclusion of either patients with LAPC having become resectable after chemotherapy or patients with rapid disease progression...
March 18, 2024: European Radiology
https://read.qxmd.com/read/38478584/loxapine-inhibits-replication-of-hepatitis-a-virus-in-vitro-and-in-vivo-by-targeting-viral-protein-2c
#12
JOURNAL ARTICLE
Mami Matsuda, Asuka Hirai-Yuki, Osamu Kotani, Michiyo Kataoka, Xin Zheng, Daisuke Yamane, Masaru Yokoyama, Koji Ishii, Masamichi Muramatsu, Ryosuke Suzuki
No antiviral drugs currently are available for treatment of infection by hepatitis A virus (HAV), a causative agent of acute hepatitis, a potentially life-threatening disease. Chemical screening of a small-compound library using nanoluciferase-expressing HAV identified loxapine succinate, a selective dopamine receptor D2 antagonist, as a potent inhibitor of HAV propagation in vitro. Loxapine succinate did not inhibit viral entry nor internal ribosome entry site (IRES)-dependent translation, but exhibited strong inhibition of viral RNA replication...
March 13, 2024: PLoS Pathogens
https://read.qxmd.com/read/38473066/updating-the-classification-of-chronic-inflammatory-enteropathies-in-dogs
#13
REVIEW
Noémie Dupouy-Manescau, Tristan Méric, Odile Sénécat, Amandine Drut, Suzy Valentin, Rodolfo Oliveira Leal, Juan Hernandez
Chronic inflammatory enteropathies (CIEs) in dogs are currently classified based on response to sequential treatment trials into food-responsive (FREs); antibiotic-responsive (AREs); immunosuppressant-responsive (IREs); and non-responsive enteropathies (NREs). Recent studies have reported that a proportion of NRE dogs ultimately respond to further dietary trials and are subsequently misclassified. The FRE subset among CIEs is therefore probably underestimated. Moreover, alterations in the gut microbiota composition and function (dysbiosis) have been shown to be involved in CIE pathogenesis in recent research on dogs...
February 21, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38468961/endoplasmic-reticulum-stress-perk-atf4-chop-pathway-is-involved-in-non-alcoholic-fatty-liver-disease-in-type-1-diabetic-rats-the-rescue-effect-of-treatment-exercise-and-insulin-like-growth-factor-i
#14
JOURNAL ARTICLE
Shadi Mohammadpour-Asl, Behrad Roshan-Milani, Shiva Roshan-Milani, Ehsan Saboory, Bijan Ghobadian, Leila Chodari
Endoplasmic Reticulum Stress (ERS) is a key factor in the development of Non-Alcoholic Fatty Liver Disease (NAFLD) in diabetes. The current study aimed to examine the effects of exercise and IGF-I on ERS markers in liver tissue. Rats were divided into five groups (n = 8 per group), including control (CON), diabetes (DIA), diabetes + exercise (DIA + EX), diabetes + IGF-I (DIA + IGF-I), and diabetes + exercise + IGF-I (DIA + EX + IGF-I)...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38468340/high-expression-circralgps2-in-atretic-follicle-induces-chicken-granulosa-cell-apoptosis-and-autophagy-via-encoding-a-new-protein
#15
JOURNAL ARTICLE
Haorong He, Yuanhang Wei, Yuqi Chen, Xiyu Zhao, Xiaoxu Shen, Qing Zhu, Huadong Yin
BACKGROUND: The reproductive performance of chickens mainly depends on the development of follicles. Abnormal follicle development can lead to decreased reproductive performance and even ovarian disease among chickens. Chicken is the only non-human animal with a high incidence of spontaneous ovarian cancer. In recent years, the involvement of circRNAs in follicle development and atresia regulation has been confirmed. RESULTS: In the present study, we used healthy and atretic chicken follicles for circRNA RNC-seq...
March 11, 2024: Journal of Animal Science and Biotechnology
https://read.qxmd.com/read/38467713/one-sixth-of-amazonian-tree-diversity-is-dependent-on-river-floodplains
#16
JOURNAL ARTICLE
John Ethan Householder, Florian Wittmann, Jochen Schöngart, Maria Teresa Fernandez Piedade, Wolfgang J Junk, Edgardo Manuel Latrubesse, Adriano Costa Quaresma, Layon O Demarchi, Guilherme de S Lobo, Daniel P P de Aguiar, Rafael L Assis, Aline Lopes, Pia Parolin, Iêda Leão do Amaral, Luiz de Souza Coelho, Francisca Dionízia de Almeida Matos, Diógenes de Andrade Lima Filho, Rafael P Salomão, Carolina V Castilho, Juan Ernesto Guevara-Andino, Marcelo de Jesus Veiga Carim, Oliver L Phillips, Dairon Cárdenas López, William E Magnusson, Daniel Sabatier, Juan David Cardenas Revilla, Jean-François Molino, Mariana Victória Irume, Maria Pires Martins, José Renan da Silva Guimarães, José Ferreira Ramos, Domingos de Jesus Rodrigues, Olaf S Bánki, Carlos A Peres, Nigel C A Pitman, Joseph E Hawes, Everton José Almeida, Luciane Ferreira Barbosa, Larissa Cavalheiro, Márcia Cléia Vilela Dos Santos, Bruno Garcia Luize, Evlyn Márcia Moraes de Leão Novo, Percy Núñez Vargas, Thiago Sanna Freire Silva, Eduardo Martins Venticinque, Angelo Gilberto Manzatto, Neidiane Farias Costa Reis, John Terborgh, Katia Regina Casula, Flávia R C Costa, Euridice N Honorio Coronado, Abel Monteagudo Mendoza, Juan Carlos Montero, Ted R Feldpausch, Gerardo A Aymard C, Chris Baraloto, Nicolás Castaño Arboleda, Julien Engel, Pascal Petronelli, Charles Eugene Zartman, Timothy J Killeen, Lorena Maniguaje Rincón, Beatriz S Marimon, Ben Hur Marimon-Junior, Juliana Schietti, Thaiane R Sousa, Rodolfo Vasquez, Bonifacio Mostacedo, Dário Dantas do Amaral, Hernán Castellanos, Marcelo Brilhante de Medeiros, Marcelo Fragomeni Simon, Ana Andrade, José Luís Camargo, William F Laurance, Susan G W Laurance, Emanuelle de Sousa Farias, Maria Aparecida Lopes, José Leonardo Lima Magalhães, Henrique Eduardo Mendonça Nascimento, Helder Lima de Queiroz, Roel Brienen, Pablo R Stevenson, Alejandro Araujo-Murakami, Tim R Baker, Bruno Barçante Ladvocat Cintra, Yuri Oliveira Feitosa, Hugo F Mogollón, Janaína Costa Noronha, Flávia Rodrigues Barbosa, Rainiellen de Sá Carpanedo, Joost F Duivenvoorden, Miles R Silman, Leandro Valle Ferreira, Carolina Levis, José Rafael Lozada, James A Comiskey, Freddie C Draper, José Julio de Toledo, Gabriel Damasco, Nállarett Dávila, Roosevelt García-Villacorta, Alberto Vicentini, Fernando Cornejo Valverde, Alfonso Alonso, Luzmila Arroyo, Francisco Dallmeier, Vitor H F Gomes, Eliana M Jimenez, David Neill, Maria Cristina Peñuela Mora, Fernanda Antunes Carvalho, Fernanda Coelho de Souza, Kenneth J Feeley, Rogerio Gribel, Marcelo Petratti Pansonato, Marcos Ríos Paredes, Jos Barlow, Erika Berenguer, Kyle G Dexter, Joice Ferreira, Paul V A Fine, Marcelino Carneiro Guedes, Isau Huamantupa-Chuquimaco, Juan Carlos Licona, Toby Pennington, Boris Eduardo Villa Zegarra, Vincent Antoine Vos, Carlos Cerón, Émile Fonty, Terry W Henkel, Paul Maas, Edwin Pos, Marcos Silveira, Juliana Stropp, Raquel Thomas, Doug Daly, William Milliken, Guido Pardo Molina, Ima Célia Guimarães Vieira, Bianca Weiss Albuquerque, Wegliane Campelo, Thaise Emilio, Alfredo Fuentes, Bente Klitgaard, José Luis Marcelo Pena, Priscila F Souza, J Sebastián Tello, Corine Vriesendorp, Jerome Chave, Anthony Di Fiore, Renato Richard Hilário, Luciana de Oliveira Pereira, Juan Fernando Phillips, Gonzalo Rivas-Torres, Tinde R van Andel, Patricio von Hildebrand, William Balee, Edelcilio Marques Barbosa, Luiz Carlos de Matos Bonates, Hilda Paulette Dávila Doza, Ricardo Zárate Gómez, Therany Gonzales, George Pepe Gallardo Gonzales, Bruce Hoffman, André Braga Junqueira, Yadvinder Malhi, Ires Paula de Andrade Miranda, Linder Felipe Mozombite-Pinto, Adriana Prieto, Agustín Rudas, Ademir R Ruschel, Natalino Silva, César I A Vela, Stanford Zent, Egleé L Zent, Angela Cano, Yrma Andreina Carrero Márquez, Diego F Correa, Janaina Barbosa Pedrosa Costa, Bernardo Monteiro Flores, David Galbraith, Milena Holmgren, Michelle Kalamandeen, Marcelo Trindade Nascimento, Alexandre A Oliveira, Hirma Ramirez-Angulo, Maira Rocha, Veridiana Vizoni Scudeller, Rodrigo Sierra, Milton Tirado, Maria Natalia Umaña, Geertje van der Heijden, Emilio Vilanova Torre, Manuel Augusto Ahuite Reategui, Cláudia Baider, Henrik Balslev, Sasha Cárdenas, Luisa Fernanda Casas, William Farfan-Rios, Cid Ferreira, Reynaldo Linares-Palomino, Casimiro Mendoza, Italo Mesones, Germaine Alexander Parada, Armando Torres-Lezama, Ligia Estela Urrego Giraldo, Daniel Villarroel, Roderick Zagt, Miguel N Alexiades, Edmar Almeida de Oliveira, Karina Garcia-Cabrera, Lionel Hernandez, Walter Palacios Cuenca, Susamar Pansini, Daniela Pauletto, Freddy Ramirez Arevalo, Adeilza Felipe Sampaio, Elvis H Valderrama Sandoval, Luis Valenzuela Gamarra, Hans Ter Steege
Amazonia's floodplain system is the largest and most biodiverse on Earth. Although forests are crucial to the ecological integrity of floodplains, our understanding of their species composition and how this may differ from surrounding forest types is still far too limited, particularly as changing inundation regimes begin to reshape floodplain tree communities and the critical ecosystem functions they underpin. Here we address this gap by taking a spatially explicit look at Amazonia-wide patterns of tree-species turnover and ecological specialization of the region's floodplain forests...
March 11, 2024: Nature Ecology & Evolution
https://read.qxmd.com/read/38467613/dcas13-mediated-translational-repression-for-accurate-gene-silencing-in-mammalian-cells
#17
JOURNAL ARTICLE
Antonios Apostolopoulos, Naohiro Kawamoto, Siu Yu A Chow, Hitomi Tsuiji, Yoshiho Ikeuchi, Yuichi Shichino, Shintaro Iwasaki
Current gene silencing tools based on RNA interference (RNAi) or, more recently, clustered regularly interspaced short palindromic repeats (CRISPR)‒Cas13 systems have critical drawbacks, such as off-target effects (RNAi) or collateral mRNA cleavage (CRISPR‒Cas13). Thus, a more specific method of gene knockdown is needed. Here, we develop CRISPRδ, an approach for translational silencing, harnessing catalytically inactive Cas13 proteins (dCas13). Owing to its tight association with mRNA, dCas13 serves as a physical roadblock for scanning ribosomes during translation initiation and does not affect mRNA stability...
March 11, 2024: Nature Communications
https://read.qxmd.com/read/38466070/inhibition-of-ca2-induced-macrophage-oxidative-stress-cascade-in-mice-with-ulcerative-colitis
#18
JOURNAL ARTICLE
Hao Yan, Guohong Li
CONTEXT: In the context of ulcerative coloproctitis (UC), a chronic and non-specific inflammatory condition of the colon and rectum with an elusive etiology, the therapeutic potential of G protein-coupled receptor 109a (GPR109a) has gained prominence. GPR109a is expressed in various cell types including colonic epithelium, adipocytes, neutrophils, and macrophages, positioning it as a promising candidate for pharmacological intervention in colitis. OBJECTIVE: the mechanistic role of GPR109a in a mouse model of UC and to assess its capacity to mitigate the disease's progression...
March 8, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38454823/propensity-score-matched-analysis-comparing-perioperative-functional-and-safety-outcomes-between-thulium-fiber-laser-and-bipolar-enucleation-of-the-prostate-performed-by-a-single-surgeon-with-two-years-of-follow-up
#19
JOURNAL ARTICLE
Armais Albertovich Kamalov, Nikolay Ivanovich Sorokin, Vitaly Kazichanovich Dzitiev, Andrey Alekseevich Strigunov, Olga Yurevna Nesterova, Ilya Vladimirovich Bondar
PURPOSE: To compare perioperative, functional, and safety outcomes between thulium fiber laser enucleation of the prostate (ThuFLEP) and bipolar enucleation of the prostate performed by a single surgeon with use of propensity score (PS)-matched analysis. MATERIALS AND METHODS: Data were from 675 patients, 422 of whom underwent ThuFLEP and bipolar enucleation by a single highly experienced surgeon. ThuFLEP was performed with Fiberlase U1 (IRE Polus Ltd.). Perioperative parameters, safety, and functional outcomes, such as International Prostate Symptom Score (IPSS), quality of life (QoL), postvoid residual volume (PVR), and maximum urinary flow rate (Qmax) were assessed...
March 2024: Investigative and Clinical Urology
https://read.qxmd.com/read/38452404/combining-cisplatin-with-pinellia-pedatisecta-schott-lipid-soluble-extract-induces-tumor-immunogenic-cell-death-in-cervical-cancer
#20
JOURNAL ARTICLE
Congwen Wang, Mingxing Zhang, Jing Peng, Meng Zhang, Chong Lu, Xingling Qi, Qingyan Luo, Yumeng Wang, Guiling Li
BACKGROUND: Pinellia pedatisecta Schott extract (PE) is extracted from Pinellia pedatisecta Schott (PPS), a traditional Chinese medicinal plant with the potential for direct anticancer effects or eliciting an anti-tumor response by activating the immune system. PURPOSE: To explore PE's ability and mechanism to reconstruct cisplatin's immunogenicity. METHODS: Cervical cancer cells were treated with cisplatin (CDDP) and/or PE. The exposure of calreticulin (CRT) on cell membrane was investigated by flow cytometry...
March 3, 2024: Phytomedicine
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