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https://www.readbyqxmd.com/read/29317375/does-doxorubicin-survive-thermal-ablation-results-of-an-ex-vivo-bench-top-study
#1
Joseph D Morrison, Collin K Schlager, Amanda E Lee, Richard B van Breemen, Ron C Gaba
PURPOSE: We aimed to test the hypothesis that doxorubicin (DOX) survives thermal ablative heating in an ex vivo model of combined transarterial chemoembolization (TACE) and thermal ablation. METHODS: Fresh porcine psoas major muscle (3 samples, 15×10×3 cm) was submerged in aqueous DOX solution (60 µg/mL, 0.1 M) for 24 hours to passively saturate tissue. DOX-infused tissue was then dried and treated with microwave ablation (MWA) using a 2.45 GHz antenna at 65 W for 2, 5, and 10 minutes...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29312649/microwave-ablation-versus-radiofrequency-ablation-for-the-treatment-of-pulmonary-tumors
#2
Feng Shi, Guangxiao Li, Zejian Zhou, Rongde Xu, Weike Li, Wenhang Zhuang, Zide Chen, Xiaoming Chen
To retrospectively compare the efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) in the treatment of pulmonary tumors, a total of 75 patients with lung tumor who underwent thermal ablation therapy in Guangdong General Hospital into the study from March 2007 to December 2014 were enrolled. Of the patients, 43 received radiofrequency ablation and 32 received microwaves ablation. The response rates, overall survival (OS), and complications rates between the RFA group and MWA group were compared...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29303011/sonographic-measurement-of-thyroid-nodule-changes-after-microwave-ablation-relationship-between-multiple-parameters
#3
Ying Wei, Linxue Qian, Ji-Bin Liu, Yujiang Liu
OBJECTIVE: Microwave ablation (MWA) is an effective technique for the treatment of benign thyroid nodules. The aim of this study was to investigate whether it is necessary to study changes in variables other than the volume reduction between follow-up intervals. This study also introduced the index R (Ssurface/V) to explore whether it could reflect features of shape between follow-up intervals. MATERIALS AND METHODS: A total of 236 complex benign thyroid nodules in 230 patients who underwent MWA in our department from October 2013 to February 2017 were included...
January 5, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29299366/bridging-therapy-effectiveness-in-the-treatment-of-hepatocellular-carcinoma-prior-to-orthotopic-liver-transplantation
#4
Maria M Rubinstein, Andreas Kaubisch, Milan Kinkhabwala, John Reinus, Qiang Liu, Jennifer W Chuy
Background: Orthotopic liver transplantation (OLT) is the most effective treatment for hepatocellular carcinoma (HCC) in patients with underlying cirrhosis and portal hypertension. Availability of OLT is limited by donor-organ shortages, which increase patient waiting time until OLT. A variety of bridging therapies (BT) have been used to halt tumor progression in patients on the OLT waiting list. Despite complete radiologic responses following BT, viable tumor is often present in explants...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29278340/microwave-ablation-of-pancreatic-tumors
#5
Thomas J Vogl, Bita Panahi, Moritz H Albrecht, Nagy Naguib Naeem Naguib, Nour-Eldin A Nour-Eldin, Tatjana Gruber-Rouh, Zachary M Thompson, Lajos M Basten
OBJECTIVES: To evaluate the clinical performance of percutaneous microwave ablation (MWA) for treatment of locally-advanced-pancreatic-cancer (LAPC). MATERIAL AND METHODS: Twenty-two MWA sessions (August 2015-March 2017) in 20 patients with primary pancreatic cancer (13 men, 7 women, mean-age: 59.9 ± 8.6 years, range: 46-73 years), who had given informed consent, were retrospectively evaluated. All procedures were performed percutaneously under CT-guidance using the same high-frequency (2...
December 26, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29237896/microwave-ablation-results-with-three-different-diameters-of-antennas-in-ex-vivo-bovine-and-in-vivo-porcine-liver
#6
Ze Song, Han Qi, Hao Zhang, Lin Xie, Fei Cao, Weijun Fan, Chao Wan
PURPOSE: To evaluate the ablation ranges and temperature rising rates of three microwave antenna with different diameters in vitro bovine and in vivo porcine livers. MATERIALS AND METHODS: In vitro and in vivo study, microwave ablations (MWA) were induced at a power output of 70 W for 5, 8, and 10 min; a total of 54 and 36 ablations were performed, respectively. Temperature measurements were performed in the 70 W/10 min group with 3 different microwave antennas...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29225619/clinical-application-of-ct-guided-percutaneous-microwave-ablation-for-the-treatment-of-lung-metastasis-from-colorectal-cancer
#7
Lin Li, Ketong Wu, Haiyang Lai, Bo Zhang
Objective: The aim of our research is to explore the clinical efficacy and safety of CT-guided percutaneous microwave ablation (MWA) for the treatment of lung metastasis from colorectal cancer. Materials and Methods: CT-guided percutaneous MWA was performed in 22 patients (male 14, female 8, mean age: 56.05 ± 12.32 years) with a total of 36 lung metastatic lesions from colorectal cancer between February 2014 and May 2017. Clinical data were retrospectively analyzed with respect to the efficacy, safety, and outcome...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29204695/percutaneous-image-guided-ablation-in-the-treatment-of-osseous-metastases-from-non-small-cell-lung-cancer
#8
Yuntong Ma, Adam N Wallace, Saiama N Waqar, Daniel Morgensztern, Thomas P Madaelil, Anderanik Tomasian, Jack W Jennings
INTRODUCTION: Percutaneous image-guided ablation is an emerging minimally invasive therapy for patients with metastatic bone disease for whom radiation therapy is ineffective or contraindicated. The purpose of this study was to examine the safety and efficacy of percutaneous ablation in achieving pain palliation and local tumor control of osseous metastases from non-small cell lung cancer (NSCLC). METHODS: A retrospective review was performed of 76 musculoskeletal metastases in 45 patients treated with percutaneous ablation...
December 4, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29202667/percutaneous-microwave-ablation-of-renal-cell-carcinoma-using-a-high-power-microwave-system-focus-upon-safety-and-efficacy
#9
D K Filippiadis, C Gkizas, M Chrysofos, A Siatelis, G Velonakis, E Alexopoulou, A Kelekis, E Brountzos, N Kelekis
OBJECTIVES: Percutaneous ablation is an expanding, minimally invasive approach for small- to medium-sized renal masses. The purpose of this study is to review safety, and mid-term efficacy of percutaneous microwave ablation (MWA) for Renal Cell Carcinoma (RCC) treatment using a high power microwave system. METHODS AND MATERIALS: Institutional database research identified 50 consecutive patients with a single lesion resembling renal cell carcinoma in CT and MRI who underwent percutaneous microwave ablation using a high power microwave system...
December 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29201222/contrast-enhanced-ultrasound-is-better-than-magnetic-resonance-imaging-in-evaluating-the-short-term-results-of-microwave-ablation-treatment-of-uterine-fibroids
#10
Yan Zhang, Meiwu Zhang, Xiaoxiang Fan, Dafeng Mao
Contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) were compared in evaluating the short-term effects of microwave ablation (MWA) on uterine fibroids. A total of 60 patients with uterine fibroids treated by MWA were enrolled in the experimental group during their two-year follow-up period according to the inclusion criteria. Conventional two-dimensional US, MRI and CEUS were performed to determine the volume reduction and the fibroid residue by displaying the size, echo and signal intensity of fibroids prior to and after MWA treatment...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29171645/cardiovascular-risk-factors-and-white-matter-hyperintensities-in-patients-with-migraine-without-aura
#11
Ceyla Ataç Uçar, Hafize Nalan Güneş, Cemile Sencer Demircan, Burcu Gökçe Çokal, Selda Keskin Güler, Tahir Kurtuluş Yoldaş
OBJECTIVES: White matter hyperintensities (WMHs) are observed in patients with migraine with aura (MWA) and without aura (MWO), but there are a limited number of studies regarding patients with MWA. In this study, we aimed to investigate the cardiovascular risk factors which may play a role in the development of WMHs in patients with MWO. METHODS: This observational, analytical, case-control study was conducted between June 2016 and January 2017. It included 21 patients with MWO who had WMHs on brain MRI and 19 patients with MWO who tested normal on MRI (control group) at the Neurology Department Outpatient Polyclinic, Ankara Training and Research Hospital...
October 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29161924/ultrasound-guided-percutaneous-microwave-ablation-vs-surgical-resection-for-thoracoabdominal-wall-implants-from-hepatocellular-carcinoma-intermediate-term-results
#12
Chao An, Zi-Long Hu, Ping Liang, Zhi-Gang Cheng, Zhi-Yu Han, Jie Yu, Fang-Yi Liu
OBJECTIVE: The aims of this study were to compare the clinical outcomes between ultrasound (US)-guided percutaneous microwave ablation (MWA) and surgical resection (SR) in patients with thoracoabdominal wall implants from hepatocellular carcinom (HCC) and to identify the prognostic factors associated with the two treatment methods. MATERIALS AND METHODS: A total of 47 patients (mean age, 56.7 ± 15.9 years, range, 18-78 years; 34 men and 13 women) with 61 thoracoabdominal wall HCC seeding were included from April 2007 to May 2017...
November 21, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29123005/percutaneous-ablation-for-hepatocellular-carcinoma-and-peritoneal-dialysis
#13
Annabel Boyer, Marc-Antoine Jegonday, Antoine Lanot, Maxence Ficheux, Thierry Lobbedez, Clémence Bechade
Hepatocellular carcinoma (HCC) is the second leading cause of death by cancer worldwide. Resection and liver transplantation are the gold standards, but only a minority of people are eligible. Percutaneous ablation therapies, such as microwave ablation (MWA), have consequently been developed. There is a lack of guidelines regarding the treatment of HCCs in end-stage renal disease (ESRD) patients. Here, we report the case of a 67-year-old patient who was undergoing peritoneal dialysis (PD) for chronic congestive heart failure and who presented with an HCC while undergoing PD...
November 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29108316/ultrasound-guided-percutaneous-microwave-ablation-of-benign-breast-lesions
#14
Jie Yu, Bao-Hua Chen, Jing Zhang, Zhi-Yu Han, Han Wu, Yan Huang, Meng-Juan Mu, Ping Liang
The benign breast lesions (BBLs) share a high incidence for women and therapy methods with minimal invasion and better cosmetic outcome are thirsted for. In this study, 122 patients with 198 biopsy-proved BBLs were enrolled. Ultrasound (US)-guided microwave ablation (MWA) was performed with local anesthesia from November, 2013 to April, 2016. The mean longest tumor size assessed was 1.6±0.7 cm (ranging 0.7-4.9 cm). MWA was successfully performed in all cases including 85 lesions adjacent to the skin, pectoralis and areola...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108305/ct-guided-microwave-ablation-through-the-lungs-for-treating-liver-tumors-near-the-diaphragm
#15
Han Qi, Hao Zhang, Chao Wan, Lin Xie, Ze Song, Weijun Fan
Purpose: To explore the short-term efficacy and safety of CT-guided microwave ablation (MWA) for treating liver tumors near the diaphragm. Results: The complete response (CR) rate for CT-guided MWA through the lung was 94.7% (124/131). The incomplete response (ICR) rate was 5.3% (7/131), of which 6 patients with ICRs achieved CRs after MWA. The CR rate for Group I was higher than Group II (99.0% vs. 80.0%, P=0.001). The mean follow-up time was 11.2 ±7.50 months...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29096566/perivascular-extension-of-microwave-ablation-zone-demonstrated-using-an-ex-vivo-porcine-perfusion-liver-model
#16
Saurabh Singh, Pulathis Nilantha Siriwardana, Edward William Johnston, Jennifer Watkins, Steve Bandula, Rowland Illing, Brian Ritchie Davidson
Microwave ablation (MWA) has been proposed to suffer less from the heat sink effect compared to radiofrequency ablation but has been reported to cause extension of the ablation zone along intrahepatic vessels in clinical practice. To study this effect in detail, eight fresh porcine livers were perfused in an ex-vivo organ perfusion system. Livers were perfused with oxygenated, O-positive human blood at 37°C. Perfusion was discontinued immediately before ablation in the non-perfused group (n = 4) whilst in the perfused group (n = 4) perfusion was maintained during MWA (140W X 2min)...
November 2, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29082799/the-efficacy-and-safety-of-microwave-ablation-in-patients-with-retroperitoneal-metastases
#17
Zhigang Wei, Xin Ye, Xia Yang, Aimin Zheng, Guanghui Huang, Shenming Dong, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Yang Ni
BACKGROUND: Retroperitoneal metastases are common, and most present with symptoms; however, treatments for this condition are limited. This retrospective study verified the efficacy and safety of microwave ablation (MWA) in retroperitoneal metastases patients. METHODS: Patients with pathologically confirmed malignant carcinoma and imaging showing retroperitoneal metastases were enrolled and underwent MWA. The end-points included objective response rate, time to local progression (TTLP), overall survival, visual analogue scale (VAS) score, dose of morphine pre- and post-ablation and complications...
October 30, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29066127/in-vivo-percutaneous-microwave-ablation-in-kidneys-correlation-with-ex-vivo-data-and-ablation-work
#18
C Marcelin, J Leiner, S Nasri, F Petitpierre, Y Le Bras, M Yacoub, N Grenier, J C Bernhard, F Cornelis
PURPOSE: To compare diameters of in vivo microwave ablation (MWA) performed in swine kidneys with ex vivo diameters, and to correlate with ablation work (AW), a new metric reflecting total energy delivered. MATERIAL AND METHODS: Eighteen in vivo MWA were performed in 6 swine kidneys successively using one or two antennas (MicroThermX(®)). Ablation consisted in delivering power (45-120W) for 5-15minutes. Ex vivo diameters were provided by the vendors and obtained on bovine liver tissue...
October 21, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29042794/comparison-of-microwave-ablation-and-hepatic-resection-for-hepatocellular-carcinoma-a-meta-analysis
#19
REVIEW
Manka Zhang, Huimin Ma, Jian Zhang, Lingling He, Xiaohui Ye, Xin Li
BACKGROUND AND AIMS: Hepatic resection (HRN) and microwave ablation (MWA) have significant advantages in treating hepatocellular carcinoma; however, it remains unclear which way produces better outcomes. This meta-analysis of cohort studies compared the treatments in terms of effectiveness and safety. METHODS: Six electronic databases (PubMed, Medline, EMBASE, Web of Science, EBSCO, and The Cochrane Library) were retrieved for studies comparing MWA and HRN. The meta-analysis was conducted based on statement of preferred reporting items for systematic reviews and meta-analyses...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29025295/ultrasonography-guided-percutaneous-microwave-ablation-for-large-hepatic-cavernous-hemangiomas
#20
Fangyi Liu, Xiaoling Yu, Ping Liang, Zhigang Cheng, Zhiyu Han, Jie Yu
PURPOSE: To evaluate the efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) for large hepatic cavernous hemangiomas (HCHs) with ablation of the feeding artery and aspiration of blood from hemangioma simultaneously. MATERIALS AND METHODS: From January 2011 to December 2016, 40 patients (29 females, 11male; average age 43.25±7.65 years) with 42 giant hepatic hemangiomas (mean diameter7.02±1.55cm, range4.1-10.8 cm) were treated with image-guided percutaneous MWA with ablation of the feeding artery and aspiration of blood from hemangioma simultaneously...
October 12, 2017: International Journal of Hyperthermia
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