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Anna Maria Ierardi, Francesca Giorlando, Filippo Piacentino, Federico Fontana, Raffaele Novario, Salvatore Alessio Angileri, Ejona Duka, Gianpaolo Carrafiello
PURPOSE: The aim of our study was to evaluate factors influencing effectiveness of percutaneous microwave ablation (MWA) in patients with small hepatocellular carcinoma (HCC) (<3 cm). MATERIALS AND METHODS: Between December 2007 and August 2015, 49 patients with 65 previously histological typed HCC were treated in a total of 61 sessions. Tumours were subdivided into central (>3 cm from the capsule) (n = 22) and peripheral (<3 cm from the capsule) (n = 43)...
October 15, 2016: La Radiologia Medica
Radek Frič, Erika Kristina Lindstrøm, Geir Andre Ringstad, Kent-André Mardal, Per Kristian Eide
BACKGROUND: In symptomatic Chiari malformation type 1 (CMI), impaired intracranial compliance (ICC) is associated with an increased cranio-spinal pulsatile pressure gradient. Phase-contrast magnetic resonance imaging (MRI) represents a non-invasive modality for the assessment of the pulse pressure gradient at the cranio-cervical junction (CCJ). We wished to explore how the MRI-derived pulse pressure gradient (MRI-dP) compares with invasively measured pulsatile intracranial pressure (ICP) in CMI, and with healthy controls...
October 14, 2016: Acta Neurochirurgica
Philip Joseph, Amorina Ishai, Venkatesh Mani, David Kallend, James H F Rudd, Zahi A Fayad, Ahmed Tawakol
PURPOSE: It remains unclear whether changes in arterial wall inflammation are associated with subsequent changes in the rate of structural progression of atherosclerosis. METHODS: In this sub-study of the dal-PLAQUE clinical trial, multi-modal imaging was performed using 18-fludeoxyglucose (FDG) positron emission tomography (PET, at 0 and 6 months) and magnetic resonance imaging (MRI, at 0 and 24 months). The primary objective was to determine whether increasing FDG uptake at 6 months predicted atherosclerosis progression on MRI at 2 years...
October 13, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Xuejuan Dong, Xin Li, Jie Yu, Ming-An Yu, Xiaoling Yu, Ping Liang
PURPOSE: To retrospectively review the complications of ultrasound (US)-guided percutaneous microwave ablation (MWA) of renal cell carcinoma. PATIENTS AND METHODS: In this study, 101 patients with 105 tumors seen from April 2006 to Feb 2014 were enrolled retrospectively. The patients were treated with US-guided percutaneous MWA and were followed up with contrast-enhanced US and computed tomography or magnetic resonance imaging at 1, 3, and 6 months and every 6 months thereafter...
2016: OncoTargets and Therapy
Natalie Lucchina, Dimitrios Tsetis, Anna Maria Ierardi, Francesca Giorlando, Edoardo Macchi, Elias Kehagias, Ejona Duka, Federico Fontana, Lorenzo Livraghi, Gianpaolo Carrafiello
Percutaneous radiofrequency ablation (RFA) can be as effective as surgical resection in terms of overall survival and recurrence-free survival rates in patients with small hepatocellular carcinoma (HCC). Effectiveness of RFA is adversely influenced by heat-sink effect. Other ablative therapies could be considered for larger tumors or for tumors located near the vessels. In this regard, recent improvements in microwave energy delivery systems seem to open interesting perspectives to percutaneous ablation, which could become the ablation technique of choice in the near future...
October 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Jie Yu, Ping Liang
Tumor ablation is defined as the direct application of chemical or thermal therapy to eradicate or substantially destroy a tumor. Currently, minimally invasive ablation techniques are available for the local destruction of focal tumors in multiple organ sites. Microwave ablation is premised on the biological response of solid tumors to tissue hyperthermia, and it is a relatively low-risk procedure. Due to several advantages of microwave ablation, including higher thermal efficiency, higher capability for coagulating blood vessels, faster ablation time, and the simultaneous application of multiple antennae, microwave ablation could be a promising minimally invasive ablation technique for the treatment of solid tumors...
October 4, 2016: International Journal of Hyperthermia
Jian-Ping Dou, Jie Yu, Zhi-Yu Han, Fang-Yi Liu, Zhi-Gang Cheng, Ping Liang
PURPOSE: To evaluate the feasibility, efficacy, and safety of microwave ablation (MWA) in the treatment of hepatocellular carcinoma associated with Budd-Chiari syndrome (BCS) after transarterial chemoembolization (TACE). METHODS: A total of 10 patients (mean 50.0 ± 7.5 years) with 15 BCS-associated HCC lesions were retrospectively evaluated. All patients received MWA treatment for residual tumors after 1 to 3 sessions of TACE. The diagnosis of residual tumors was confirmed by at least two types of enhanced imaging...
September 29, 2016: Abdominal Radiology
Thomas J Vogl, Romina Eckert, Nagy N N Naguib, Martin Beeres, Tatjana Gruber-Rouh, Nour-Eldin A Nour-Eldin
OBJECTIVE: The purpose of this study is to retrospectively evaluate local tumor control, time to tumor progression, and survival rates among patients with lung metastatic colorectal cancer who have undergone ablation therapy performed using laser-induced thermotherapy (LITT), radiofrequency ablation (RFA), or microwave ablation (MWA). MATERIALS AND METHODS: Data for this retrospective study were collected from 231 CT-guided ablation sessions performed for 109 patients (71 men and 38 women; mean [± SD] age, 68...
September 28, 2016: AJR. American Journal of Roentgenology
Sicong Ma, Min Ding, Jiang Li, Tao Wang, Xingxing Qi, Yaoping Shi, Yanan Ming, Jiachang Chi, Zhi Wang, Xiaoyin Tang, Dan Cui, Yuan Zhang, Bo Zhai
OBJECTIVE: The aim of this study was to evaluate the clinical outcomes of ultrasound-guided percutaneous microwave ablation (US-guided PMWA) for the treatment of hepatocellular carcinoma (HCC) with the analysis of prognostic factors. MATERIALS AND METHODS: The treatment and survival parameters of 433 patients with HCC (≤10 cm), who met the inclusion criteria and had received US-guided PMWA in Renji Hospital from July 2010 to November 2014, were retrospectively analyzed...
September 20, 2016: Journal of Cancer Research and Clinical Oncology
Yun Xu, Qiang Shen, Neng Wang, Pei Liu, Panpan Wu, Zhenwei Peng, Guojun Qian
OBJECTIVE: This study aims to evaluate the local efficacy and long-term outcomes of microwave ablation (MWA) for treating large unresectable hepatocellular carcinomas (HCCs). METHODS: A total of 82 patients with 5-6 cm unresectable HCCs, who underwent a single MWA procedure during the period of January 2007 to July 2011, were retrospectively enrolled into this study. Percentages of technical success and complications of MWA and HCC local recurrence (LR) after MWA were determined...
October 9, 2016: International Journal of Hyperthermia
Xiu-Feng Su, Na Li, Xu-Fang Chen, Lei Zhang, Ming Yan
BACKGROUND: Radiofrequency ablation (RFA) and microwave ablation (MWA) are the most frequently used thermal ablation methods for the treatment of liver cancer. Liver abscess is a common and severe complication of thermal ablation treatment. OBJECTIVES: The objective of this study was to determine the incidence and risk factors of liver abscess formation after thermal ablation of liver cancer. MATERIALS AND METHODS: The clinical data of 423 patients who underwent 691 thermal ablation procedures for liver cancer were collected in order to retrospectively analyze the basic characteristics, incidence, and risk factors associated with liver abscess formation...
July 2016: Hepatitis Monthly
Y Korkusuz, K Kohlhase, D Gröner, C Erbelding, W Luboldt, C Happel, S Ahmad, T J Vogl, F Gruenwald
Purpose: Microwave ablation (MWA) represents a novel thermal ablative treatment of benign thyroid nodules. The aim was to determine the energy required per ml volume reduction in order to match the required energy to the volume-of-interest (VOI). Materials and Methods: 25 patients with 25 nodules (6 solid, 13 complex and 6 cystic) were treated by microwave ablation (MWA). The transmitted energy (E) was correlated with the volume change (∆ V) after 3 months. The energy required per ml volume reduction after 3 months was calculated by E/∆ V...
September 14, 2016: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Saurabh Singh, Steven Bandula, Jeremy Brown, Jeremy Whelan, Rowland Illing
We present a case of a patient who following chemotherapy developed semi-invasive pulmonary aspergillosis and an aspergilloma in a lung cavity previously formed by microwave ablation (MWA). A 55-year-old woman presented with cough and shortness of breath after finishing three cycles of chemotherapy for a metastatic nerve sheath tumour. She had been treated by MWA for pulmonary metastases 2 years previously which resulted in a residual right apical lung cavity. Postchemotherapy imaging showed that this cavity had enlarged, developed a thicker wall and contained lobulated soft tissue with a crescent sign on coronal reformats...
2016: BMJ Case Reports
Tao Wang, Xiao-Jie Lu, Jia-Chang Chi, Min Ding, Yuan Zhang, Xiao-Yin Tang, Ping Li, Li Zhang, Xiao-Yu Zhang, Bo Zhai
This retrospective study aimed at evaluating the long-term outcomes and prognostic factors of microwave ablation (MWA) as a first-line treatment for hepatocellular carcinoma (HCC). 221 consecutive patients receiving MWA in our center between October 11, 2010 and December 31, 2013 were enrolled. Technique effectiveness was evaluated one month post-ablation. Initial complete ablation (CA1(st)) was gained in 201 (90.95%) patients, secondary CA (CA2(nd)) in 8 (3.62%) patients and the remaining 12 (5.43%) patients suffered from incomplete ablation (IA2(nd)) after two sessions of MWA...
2016: Scientific Reports
Roberto Santambrogio, Jason Chiang, Matteo Barabino, Franca Maria Meloni, Emanuela Bertolini, Fabio Melchiorre, Enrico Opocher
BACKGROUND: Laparoscopic thermal ablation is a common alternative to surgical resection in treating hepatic tumors, particularly in those located in difficult-to-reach locations. OBJECTIVE: The aim of this study was to compare the safety and long-term efficacy of laparoscopic radiofrequency ablation (RFA) and microwave ablation (MWA) in treating hepatocellular carcinoma (HCC). METHOD: From February 2009 to May 2015, data from patients with HCC nodules who had undergone either laparoscopic MWA or laparoscopic RFA were examined...
August 31, 2016: Annals of Surgical Oncology
Jinshun Xu, Yu Chen, Liming Deng, Jianxin Liu, Yang Cao, Pan Li, Haitao Ran, Yuanyi Zheng, Zhigang Wang
The fast development of nanotechnology has provided a new efficient strategy for enhancing the therapeutic efficiency of various treatment modalities against cancer. However, the improvement of minimally invasive microwave therapy based on nanomaterials has not been realized. In this work, we successfully designed and synthesized a novel folate-targeted nanodroplet (TPN) with a composite mixture of perfluorocarbons as the core and lipid as the shell, which exerts the distinctive dual functions as the adjuvant for highly efficient percutaneous ultrasound imaging-guided microwave ablation (MWA) of tumors...
November 2016: Biomaterials
N Parvizi, D Chung, M W Little, F V Gleeson, E M Anderson
AIM: To assess the clinical utility of perfusion computed tomography (pCT) parameters in microwave ablation (MWA) of lung tumours. MATERIALS AND METHODS: Patients were included who had primary or metastatic lung tumours and underwent pCT studies immediately pre- and post-MWA. Perfusion maps of the tumours were constructed using CT perfusion software (GE, Milwaukee, WI, USA). Regions of interest were drawn on sequential axial sections to extract the pCT parameters, blood volume (BV), average blood flow (BF), and mean transit time (MTT) from the entire tumour volume...
November 2016: Clinical Radiology
Sébastien Aubry, Jonathan Dubut, Jean-Philippe Nueffer, Loic Chaigneau, Chrystelle Vidal, Bruno Kastler
PURPOSE: The aims of this work were to assess the feasibility, efficacy, short-term outcome and safety of microwave ablation (MWA) in the treatment of malignant musculoskeletal tumours. MATERIALS AND METHODS: Sixteen bone and soft-tissue malignant tumours were prospectively included and were treated by CT-guided MWA. The percentage and size of necrosis of the lesions were measured by contrast-enhanced MRI before the procedure and after 1, 3, 6 and 12 months. mRECIST criteria were used to assess tumour response...
August 23, 2016: European Radiology
Li Zhuo, Li-Li Peng, Yu-Mei Zhang, Zhi-Hong Xu, Gu-Ming Zou, Xin Wang, Wen-Ge Li, Ming-de Lu, Ming-An Yu
Purpose To evaluate the safety and efficacy of microwave ablation (MWA) in patients with end-stage renal disease and secondary hyperparathyroidism. Materials and Methods The study protocol was approved by the human ethics review committee. Between March 1, 2014, and June 30, 2015, 51 patients (25 men, 26 women; mean age ± standard deviation, 53.1 years ± 12.9) were enrolled. All patients had at least one enlarged parathyroid gland and secondary symptomatic hyperparathyroidism, which was treated with ultrasonographically (US) guided MWA...
August 22, 2016: Radiology
Matthias Jaeger, Angela K Khoo, David A Conforti, Ramesh Cuganesan
Phase contrast cine MRI with determination of pulsatile aqueductal cerebrospinal fluid (CSF) stroke volume and flow velocity has been suggested to assess intracranial pulsations in idiopathic normal pressure hydrocephalus (iNPH). We aimed to compare this non-invasive measure of pulsations to intracranial pressure (ICP) pulse wave amplitude from continuous ICP monitoring. We hypothesised that a significant correlation between these two markers of intracranial pulsations exists. Fifteen patients with suspected iNPH had continuous computerised ICP monitoring with calculation of mean ICP pulse wave amplitude (MWA) from time-domain analysis...
November 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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