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https://www.readbyqxmd.com/read/28230020/clinical-study-of-transcatheter-arterial-chemoembolization-combined-with-microwave-ablation-in-the-treatment-of-advanced-hepatocellular-carcinoma
#1
Wei Li, Wenling Man, Huanqing Guo, Po Yang
OBJECTIVE: To evaluate the safety and efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous microwave ablation (MWA) in the treatment of advanced hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Three thousand cases of advanced HCC patients were randomly divided into two groups: 1500 cases in the treatment group were treated with TACE combined with MWA and 1500 cases in the control group were treated with TACE. RESULTS: The effective rate of the treatment group and control group was 71...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28230012/safety-and-feasibility-within-24-h-of-discharge-in-patents-with-inoperable-malignant-lung-nodules-after-percutaneous-microwave-ablation
#2
Bin Li, Zhiwei Wang, Kang Zhou, Qinzong Gao, Xiaoguang Li
CONTEXT: Minimally invasive interventional therapy is now the more effective treatment strategy for organ-confined malignancy in patients who are poor candidates for surgery. Microwave ablation (MWA) in lung malignancy has been receiving much attention as an effective minimally invasive approach. AIMS: The aim of this study is to evaluate the safety and feasibility within 24 h of discharge of patients treated with percutaneous MWA for inoperable malignant lung nodules, and elucidate the factors predisposing to hospital readmission...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28220346/microwave-ablation-of-liver-malignancies-comparison-of-effects-and-early-outcomes-of-percutaneous-and-intraoperative-approaches-with-different-liver-conditions-new-advances-in-interventional-oncology-state-of-the-art
#3
Francesco De Cobelli, Paolo Marra, Francesca Ratti, Alessandro Ambrosi, Michele Colombo, Anna Damascelli, Claudio Sallemi, Simone Gusmini, Marco Salvioni, Pietro Diana, Federica Cipriani, Massimo Venturini, Luca Aldrighetti, Alessandro Del Maschio
Liver thermal ablation is an alternative treatment for hepatocellular carcinoma (HCC) and secondary liver malignancies. Microwave ablation (MWA) produces large ablation zones (AZ) in short time; however, AZ prediction is based on preclinical ex vivo models, rising concerns about reproducibility and safety in humans. We aimed to investigate the effects produced by a new-generation MWA system on human liver in vivo with different approaches (percutaneous or intraoperative) and liver conditions (cirrhosis or previous chemotherapy treatment), in comparison with manufacturer-provided predictions based on ex vivo animal models...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28203621/comparative-study-evaluating-the-efficiency-of-cooled-and-uncooled-single-treatment-mwa-in-thyroid-nodules-after-a-3-month-follow-up
#4
Oscar Maximilian Mader, Nadine Farivar Tanha, Alexander Mader, Christian Happel, Yücel Korkusuz, Frank Grünwald
OBJECTIVE: The aim of this study was to evaluate and compare the efficacy of single-treatment cooled and uncooled microwave ablation in thyroid nodules. METHODS: Eighteen patients (11 women) with an average age of 62 years (range: 41-80) with 18 cold, mainly solid or solid thyroid nodules were treated with cooled or uncooled microwave ablation. Pain during the treatment was measured on a 10-point score. Side effects revealed by ultrasound or patients' complaints were documented...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28185998/study-on-the-effect-of-chemoembolization-combined-with-microwave-ablation-for-the-treatment-of-hepatocellular-carcinoma-in-rats
#5
Thomas Josef Vogl, Jun Qian, Andreas Tran, Elsie Oppermann, Nagy N Naguib, Huedayi Korkusuz, Nour Eldin A Nour Eldin, Wolf Otto Bechstein
PURPOSE: We aimed to evaluate the combining effects of transarterial chemoembolization (TACE) and open local thermal microwave ablation (MWA) in a hepatocellular carcinoma animal model. METHODS: Tumor cubes were implanted into the liver of 30 male inbred ACI rats. Groups of 10 animals were treated at 13 days (TACE or MWA) and 16 days (MWA) postimplantation with combined therapy (study group A) of TACE (0.1 mg mitomycin C; 0.1 mg iodized oil; 5.0 mg degradable starch microspheres) and MWA (2450 Mhz; 45 s; 35 W), TACE (control group B) or MWA (control group C) alone...
February 10, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28184165/visual-spatial-training-efficacy-in-children-affected-by-migraine-without-aura-a-multicenter-study
#6
Francesco Precenzano, Maria Ruberto, Lucia Parisi, Margherita Salerno, Agata Maltese, Beatrice Gallai, Rosa Marotta, Serena Marianna Lavano, Francesco Lavano, Michele Roccella
Routinely in the clinical practice, children affected by migraine without aura (MwA) tend to exhibit severe and persistent difficulties within cognitive processes such as attention, memory, and visual-motor integration (VMI) skills. The aim of this study was to assess the visual-spatial and visual-motor abilities among a sample of children with MwA and the effects of a specific computerized training. The study population was composed of 84 patients affected by MwA (39 girls and 45 boys; mean age: 8.91±2.46 years), and they were randomly divided into two groups (group A and group B) comparable for age (P=0...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28180923/early-assessment-of-coagulation-necrosis-after-hepatic-microwave-ablation-a-comparison-of-non-enhanced-and-enhanced-t1-weighted-images
#7
Zhen-Yu Jia, Qi-Feng Chen, Zheng-Qiang Yang, Wen-Tao Wu, Hai-Bin Shi, Sheng Liu
PURPOSE: To compare the technical success and accuracy of hepatic microwave ablation (MWA) using non-enhanced and enhanced T1-weighted imaging early after ablation. Patients were evaluated with regard to the ablation zone and local tumor progression (LTP). METHODS: This retrospective study conducted between September 2014 and December 2015 which consisted of 56 patients with 56 hepatic malignant lesions who underwent percutaneous MWA. Non-enhanced and contrast-enhanced T1-weighted imagings were performed within 2 days after tumor ablation...
February 8, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28161824/a-three-dimensional-visualization-preoperative-treatment-planning-system-for-microwave-ablation-in-liver-cancer-a-simulated-experimental-study
#8
Fangyi Liu, Zhigang Cheng, Zhiyu Han, Xiaoling Yu, Mingan Yu, Ping Liang
PURPOSE: To evaluate the application value of three-dimensional (3D) visualization preoperative treatment planning system (VPTPS) for microwave ablation (MWA) in liver cancer. MATERIALS AND METHODS: The study was a simulated experimental study using the CT imaging data of patients in DICOM format in a model. Three students (who learn to interventional ultrasound for less than 1 year) and three experts (who have more than 5 years of experience in ablation techniques) in MWA performed the preoperative planning for 39 lesions (mean diameter 3...
February 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28152680/recommendations-for-the-delivery-of-focal-tumor-ablation-services
#9
Cassandra McKay, Jonathan Wang, Fulvia Baldassarre, Amanda Wong, Deanna Langer, John Kachura, Julian Dobranowski
: 106 Background: The objective of this work was to develop recommendations for the organization and delivery of focal tumor ablation services. New, minimally-invasive ablation technologies such as radiofrequency ablation (RFA), microwave ablation (MWA), and transcatheter arterial chemoembolization (TACE) offer treatment options for patients with a variety of cancers. These emerging therapies can improve patient care (minimize side-effects, offer more rapid recovery with comparable or enhanced outcomes) compared to traditional approaches...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28149799/microwave-ablation-for-thyroid-nodules-a-new-string-to-the-bow-for-percutaneous-treatments
#10
Francesco Morelli, Andrea Sacrini, Giovanni Pompili, Anna Borelli, Silvia Panella, Annamaria Masu, Loredana De Pasquale, Roberta Giacchero, Gianpaolo Carrafiello
BACKGROUND: Thyroid nodules are a fairly common finding in general population and, even if most of them are benign, a treatment can be however necessary. In the last years, non surgical minimally invasive techniques have been developed to treat this pathology, starting from percutaneous ethanol injection (PEI), to laser ablation (LA), radiofrequency ablation (RFA) and, most recently, microwave ablation (MWA). METHODS: We reviewed all medical literature searching in pubmed...
December 2016: Gland Surgery
https://www.readbyqxmd.com/read/28137271/microwave-ablation-combined-with-ok-432-induces-th1-type-response-and-specific-antitumor-immunity-in-a-murine-model-of-breast-cancer
#11
Li Li, Wei Wang, Hong Pan, Ge Ma, Xinyi Shi, Hui Xie, Xiaoan Liu, Qiang Ding, Wenbin Zhou, Shui Wang
BACKGROUND: Minimally invasive therapies, such as microwave ablation (MWA), are widely used for the treatment of solid tumors. Previous studies suggest that MWA is feasible for the treatment of small breast cancer, and thermal ablation may induce adaptive antitumor immunity. However, the induced immune responses are mostly weak, and the immunomodulation effects of MWA in breast cancer are unclear. Immunostimulant OK-432 can induce tumor-specific T-cell responses and may augment the immunity induced by MWA...
January 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28124204/interictal-brain-activity-differs-in-migraine-with-and-without-aura-resting-state-fmri-study
#12
Péter Faragó, Bernadett Tuka, Eszter Tóth, Nikoletta Szabó, András Király, Gergő Csete, Délia Szok, János Tajti, Árpád Párdutz, László Vécsei, Zsigmond Tamás Kincses
BACKGROUND: Migraine is one of the most severe primary headache disorders. The nature of the headache and the associated symptoms during the attack suggest underlying functional alterations in the brain. In this study, we examined amplitude, the resting state fMRI fluctuation in migraineurs with and without aura (MWA, MWoA respectively) and healthy controls. METHODS: Resting state functional MRI images and T1 high-resolution images were acquired from all participants...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28112263/a-clinical-study-of-thermal-monitoring-techniques-of-ultrasound-guided-microwave-ablation-for-hepatocellular-carcinoma-in-high-risk-locations
#13
Han Zhi-Yu, Liang Ping, Yu Xiao-Ling, Cheng Zhi-Gang, Liu Fang-Yi, Yu Jie
To confirm the safety and effectiveness of the minimally invasive thermal monitor technique on percutaneous ultrasound-guided microwave ablation (MWA) for hepatocellular carcinoma (HCC) in high-risk locations, a total of 189 patients with 226 HCC nodules in high-risk locations were treated with MWA. The real-time temperature of the tissue between the lesion margin and the vital structures was monitored by inserting a 21G thermal monitoring needle. The major indexes of technical success, technique effectiveness, local tumour progression and complications were observed during the follow-up period...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28109674/single-center-nonrandomized-clinical-trial-to-assess-the-safety-and-efficacy-of-irreversible-electroporation-ire-ablation-of-liver-tumors-in-humans-short-to-mid-term-results
#14
P Frühling, A Nilsson, F Duraj, U Haglund, A Norén
INTRODUCTION: A single-center nonrandomized clinical trial was performed to assess the safety and efficacy of IRE ablation of liver tumors in humans. METHODS: 38 malignant liver tumors on 30 patients were treated with IRE between September 2011 and September 2014. Treatment was with curative intent, and the diagnoses were colorectal cancer with liver metastases (CRLM) (n = 23), hepatocellular carcinoma (HCC) (n = 8) and other metastasis (n = 7). Patients were selected when surgery, radiofrequency ablation (RFA) or microwave ablation (MWA) was not an option, and when they met inclusion criteria (tumor size < 3 cm, 1-2 tumors)...
January 11, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28103953/microwave-ablation-is-as-effective-as-radiofrequency-ablation-for-very-early-stage-hepatocellular-carcinoma
#15
Yun Xu, Qiang Shen, Neng Wang, Pan-Pan Wu, Bin Huang, Ming Kuang, Guo-Jun Qian
BACKGROUND: Percutaneous radiofrequency ablation (RFA) is a first-line treatment for very-early-stage hepatocellular carcinoma (HCC), whereas the efficacy of percutaneous microwave ablation (MWA) for very-early-stage HCC remains unclear. The purpose of this study was to clarify this issue by comparing the safety and efficacy of percutaneous MWA with percutaneous RFA in treating very-early-stage HCC. METHODS: Clinical data of 460 patients who were diagnosed with very-early-stage HCC and treated with percutaneous MWA or RFA between January 2007 and July 2012 at the Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, in Shanghai, China were retrospectively analyzed...
January 19, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28100078/percutaneous-microwave-ablation-mwa-increased-the-serum-levels-of-vegf-and-mmp-9-in-stage-i-non-small-cell-lung-cancer-nsclc
#16
Yang Ni, Xin Ye, Chao Wan, Qing Ni, Xia Yang, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Zhigang Wei, Min Meng
BACKGROUND: Lung cancer is the leading cause of cancer death around the world. Percutaneous microwave ablation (MWA) is an emerging treatment strategy for medically inoperable early stage non-small cell lung cancer (NSCLC). In this study, we investigated the association of MWA and serum angiogensis promoters VEGF and MMP-9 in these patients subgroup. METHODS: We enrolled 52 patients with stage I NSCLC patients in this study. For each patient, blood samples were drawn by venous puncture, one immediately prior to MWA and the others on post-procedure days (PPD) 1, 3, 5, 7, 10 and 14...
January 18, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28092050/microwestern-arrays-for-systems-level-analysis-of-sh2-domain-containing-proteins
#17
Mark F Ciaccio, Richard B Jones
The Microwestern Array (MWA) method combines the scalability and miniaturization afforded by the Reverse Phase Lysate Array (RPLA) approach with the electrophoretic separation characteristic of the Western blot. This technology emulates the creation of an array of small Western blots on a single sheet of nitrocellulose allowing for the sensitive and quantitative measurement of hundreds of proteins from hundreds of cell lysates with minimal cost and maximal accuracy, precision, and reproducibility. The MWA is a versatile technology that can be easily configured for purposes such as antibody screening, cell signaling network inference, protein modification/phenotype regression analysis, and genomic/proteomic relationships...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28092049/rosette-assay-highly-customizable-dot-blot-for-sh2-domain-screening
#18
Khong Y Ng, Kazuya Machida
With a growing number of high-throughput studies, structural analyses, and availability of protein-protein interaction databases, it is now possible to apply web-based prediction tools to SH2 domain-interactions. However, in silico prediction is not always reliable and requires experimental validation. Rosette assay is a dot blot-based reverse-phase assay developed for the assessment of binding between SH2 domains and their ligands. It is conveniently customizable, allowing for low- to high-throughput analysis of interactions between various numbers of SH2 domains and their ligands, e...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28066666/ct-guided-percutaneous-microwave-ablation-of-pulmonary-malignant-tumors
#19
Wei-Chun Ko, Yee-Fan Lee, Yi-Chang Chen, Ning Chien, Yu-Sen Huang, Yao-Hui Tseng, Jang-Ming Lee, Hsao-Hsun Hsu, Jin-Shing Chen, Yeun-Chung Chang
BACKGROUND: Microwave ablation (MWA) of lung tumors is a new approach for local tumor control. The purpose of this retrospective study was to evaluate the preliminary results of safety and efficacy of MWA with a dynamic frequency range (902-928 MHz) and power (10-32 W) for local tumor control of thoracic malignancies. METHODS: From December 1, 2013 to February 1, 2016, there were total 32 lung tumors among 15 patients (7 men, 8 women, age range 43-82 years, mean 57...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28054165/percutaneous-thermal-ablation-with-ultrasound-guidance-fusion-imaging-guidance-to-improve-conspicuity-of-liver-metastasis
#20
Antoine Hakime, Steven Yevich, Lambros Tselikas, Frederic Deschamps, David Petrover, Thierry De Baere
PURPOSE: To assess whether fusion imaging-guided percutaneous microwave ablation (MWA) can improve visibility and targeting of liver metastasis that were deemed inconspicuous on ultrasound (US). MATERIALS AND METHODS: MWA of liver metastasis not judged conspicuous enough on US was performed under CT/US fusion imaging guidance. The conspicuity before and after the fusion imaging was graded on a five-point scale, and significance was assessed by Wilcoxon test. Technical success, procedure time, and procedure-related complications were evaluated...
January 4, 2017: Cardiovascular and Interventional Radiology
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