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https://www.readbyqxmd.com/read/28813818/the-effect-of-myoelectric-prosthesis-control-strategies-and-feedback-level-on-adaptation-rate-for-a-target-acquisition-task
#1
Ahmed W Shehata, Erik J Scheme, Jonathon W Sensinger
The long-term performance of myoelectric prostheses is related not only to the short-term performance of the controller, but also to the user's ability to learn and adapt to the system. Different control architectures may have inherent tradeoffs between their short-term performance and the amount of relevant feedback that informs this adaptation. In this study we focused on the ability of two common types of myoelectric control interfaces: raw control with raw feedback, such as a regression, and filtered control with filtered feedback, such as a classifier, to affect user adaptation...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813793/the-combined-action-of-a-passive-exoskeleton-and-an-emg-controlled-neuroprosthesis-for-upper-limb-stroke-rehabilitation-first-results-of-the-retrainer-project
#2
E Ambrosini, S Ferrante, J Zajc, M Bulgheroni, W Baccinelli, E d'Amico, T Schauer, C Wiesener, M Russold, M Gfoehler, M Puchinger, M Weber, S Becker, K Krakow, M Rossini, D Proserpio, G Gasperini, F Molteni, G Ferrigno, A Pedrocchi
The combined use of Functional Electrical Stimulation (FES) and robotic technologies is advocated to improve rehabilitation outcomes after stroke. This work describes an arm rehabilitation system developed within the European project RETRAINER. The system consists of a passive 4-degrees-of-freedom exoskeleton equipped with springs to provide gravity compensation and electromagnetic brakes to hold target positions. FES is integrated in the system to provide additional support to the most impaired muscles. FES is triggered based on the volitional EMG signal of the same stimulated muscle; in order to encourage the active involvement of the patient the volitional EMG is also monitored throughout the task execution and based on it a happy or sad emoji is visualized at the end of each task...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28806185/graft-quality-verification-in-coronary-artery-bypass-graft-surgery-how-when-and-why
#3
Teresa M Kieser
PURPOSE OF REVIEW: The coronary artery bypass graft (CABG) operation is one of the few remaining operations/interventions on diseased arteries that are not routinely verified during or immediately after the procedure. This review answers the 'how', 'when' and 'why' of intraoperative CABG assessment. RECENT FINDINGS: More recent than new literature on this topic, is the increased interest in quality assurance of CABG. This is most likely due to reports in the last 5 years suggesting CABG superiority to percutaneous coronary intervention (PCI) for improved mid-term and long-term outcomes; for example, for patients with diabetes mellitus (Freedom Trial by Farkouh in 2012), and for patients with SYNTAX score ≥ 33 (SYNTAX Trial by Mohr in 2013)...
August 12, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28805517/further-commentary-on-the-pace-trial-biased-methods-and-unreliable-outcomes
#4
Keith J Geraghty
Geraghty in the year 2016, outlines a range of controversies surrounding publication of results from the PACE trial and discusses a freedom of information case brought by a patient refused access to data from the trial. The PACE authors offer a response, writing 'Dr Geraghty's views are based on misunderstandings and misrepresentations of the PACE trial'. This article draws on expert commentaries to further detail the critical methodological failures and biases identified in the PACE trial, which undermine the reliability and credibility of the major findings to emerge from this trial...
August 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28803041/the-influence-of-traumatic-brain-injury-on-treatment-outcomes-of-concurrent-treatment-for-ptsd-and-substance-use-disorders-using-prolonged-exposure-cope-in-veterans
#5
Daniel F Gros, Cynthia L Lancaster, Michael David Horner, Derek D Szafranski, Sudie E Back
BACKGROUND: The co-occurrence of posttraumatic stress disorder (PTSD), substance use disorders (SUD), and traumatic brain injury (TBI) in veterans of Operations Enduring/Iraqi Freedom and New Dawn has received much attention in the literature. Although hypotheses have been presented and disseminated that TBI history will negatively influence treatment response, little data exist to support these claims. The present study investigates the influence of TBI history on response to COPE (Concurrent Treatment of PTSD and SUD Using Prolonged Exposure), a 12-session, integrated psychotherapy designed to address co-occurring PTSD and SUD...
July 17, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28800192/efficacy-and-safety-of-driver-guided-catheter-ablation-for-atrial-fibrillation-a-systematic-review-and-meta-analysis
#6
F Daniel Ramirez, David H Birnie, Girish M Nair, Agnieszka Szczotka, Calum J Redpath, Mouhannad M Sadek, Pablo B Nery
INTRODUCTION: Targeting localized drivers (electrical rotors or focal impulses) during catheter ablation for atrial fibrillation (AF) has been proposed as a strategy to improve procedural success. However, the strength and quality of the evidence to support this approach is unclear. METHODS AND RESULTS: Clinical studies reporting efficacy or safety outcomes of driver-guided ablation for AF were identified in Medline, Embase, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, Pubmed, and conference abstracts from major scientific meetings...
August 11, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28798016/bayesian-analysis-a-practical-approach-to-interpret-clinical-trials-and-create-clinical-practice-guidelines
#7
John A Bittl, Yulei He
Bayesian analysis is firmly grounded in the science of probability and has been increasingly supplementing or replacing traditional approaches based on P values. In this review, we present gradually more complex examples, along with programming code and data sets, to show how Bayesian analysis takes evidence from randomized clinical trials to update what is already known about specific treatments in cardiovascular medicine. In the example of revascularization choices for diabetic patients who have multivessel coronary artery disease, we combine the results of the FREEDOM trial (Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease) with prior probability distributions to show how strongly we should believe in the new Class I recommendation ("should be done") for a preference of bypass surgery over percutaneous coronary intervention...
August 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28795638/short-term-results-of-the-rapid-randomized-trial-of-the-legflow-paclitaxel-eluting-balloon-with-supera-stenting-vs-supera-stenting-alone-for-the-treatment-of-intermediate-and-long-superficial-femoral-artery-lesions
#8
Sanne W de Boer, Daniel A F van den Heuvel, Debbie A B de Vries-Werson, Jan Albert Vos, Bram Fioole, Damnis Vroegindeweij, Otto E Elgersma, Rudolph P Tutein Nolthenius, Jan M M Heyligers, Gerlof P T Bosma, Bernart de Leeuw, Lee H Bouwman, Dittmar Böckler, Dmitriy I Dovzhanskiy, Floris W F Vos, Ted W F Vink, Pieter G A Hooijboer, Rutger J Hissink, Jean-Paul P M de Vries
PURPOSE: To report a randomized trial comparing the Legflow paclitaxel-eluting balloon (PEB) + Supera stenting to Supera stenting alone in patients with intermediate to long superficial femoral artery (SFA) lesions. METHODS: The multicenter RAPID trial ( controlled-trials.com ; identifier ISRCTN47846578) randomized (1:1) 160 patients (mean age 67 years; 102 men) with Rutherford category 2-6 ischemia to treatment with Legflow PEB + Supera stent or Supera stent alone in intermediate to long SFA lesions (mean lesion length 15...
August 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28789921/discontinuation-of-denosumab-therapy-for-osteoporosis-a-systematic-review-and-position-statement-by-ects
#9
REVIEW
Elena Tsourdi, Bente Langdahl, Martine Cohen-Solal, Bérengere Aubry-Rozier, Erik Fink Eriksen, Nuria Guañabens, Barbara Obermayer-Pietsch, Stuart H Ralston, Richard Eastell, M Carola Zillikens
INTRODUCTION: The optimal duration of osteoporosis treatment is controversial. As opposed to bisphosphonates, denosumab does not incorporate into bone matrix and bone turnover is not suppressed after its cessation. Recent reports imply that denosumab discontinuation may lead to an increased risk of multiple vertebral fractures. METHODS: The European Calcified Tissue Society (ECTS) formed a working group to perform a systematic review of existing literature on the effects of stopping denosumab and provide advice on management...
August 5, 2017: Bone
https://www.readbyqxmd.com/read/28780528/informed-consent-in-cluster-randomised-trials-new-and-common-ethical-challenges
#10
Sapfo Lignou
Cluster randomised trials are an increasingly important methodological tool in health research but they present challenges to the informed consent requirement. In the relatively limited literature on the ethics of cluster research there is not much clarity about the reasons for which seeking informed consent in cluster randomised trials may be morally challenging. In this paper, I distinguish between the cases where informed consent in cluster trials may be problematic due to the distinct features of 'population-based' interventions, which have not been adequately discussed in the research ethics literature, and the cases where informed consent may be problematic for reasons that investigators also encounter in other research designs...
August 5, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28779921/secondary-psychological-outcomes-in-a-controlled-trial-of-emotional-freedom-techniques-and-cognitive-behaviour-therapy-in-the-treatment-of-food-cravings
#11
Peta Stapleton, Amy Bannatyne, Hannah Chatwin, Keri-Charle Urzi, Brett Porter, Terri Sheldon
OBJECTIVE: Examining the effectiveness of psychological interventions in treating secondary psychological outcomes of obesity has become prioritized in recent times. The objective of the present study was to compare an eight-week Cognitive-Behavioural Therapy (CBT) and Emotional Freedom Techniques (EFT) intervention program, in the treatment of food cravings and secondary psychological outcomes among overweight or obese adults (N = 83). METHOD: A controlled non-inferiority trial was performed comparing group-delivered CBT to group-delivered EFT...
August 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28765753/adenosine-guided-radiofrequency-catheter-ablation-of-atrial-fibrillation-a-meta-analysis-of-randomized-control-trials
#12
REVIEW
Konstantinos P Letsas, Stamatis Georgopoulos, Michael Efremidis, Tong Liu, George Bazoukis, Konstantinos Vlachos, Nikolaos Karamichalakis, Louiza Lioni, Antonios Sideris, Joachim R Ehrlich
BACKGROUND: The prognostic significance of adenosine-mediated dormant pulmonary vein conduction, and whether such dormant conduction should be eliminated, remains controversial. We sought to perform a meta-analysis of data from eligible studies to delineate the prognostic impact of adenosine-guided radiofrequency catheter ablation of atrial fibrillation. METHODS: A systematic literature search was performed using online databases in order to identify relevant studies from January 2004 to September 2016...
August 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28755930/locomotion-characteristics-of-dairy-cows-walking-on-pasture-and-the-effect-of-artificial-flooring-systems-on-locomotion-comfort
#13
M Alsaaod, S Huber, G Beer, P Kohler, G Schüpbach-Regula, A Steiner
The locomotion comfort of dairy cows depends on the floor of the walking alleys. Optimal locomotion comfort is given when cows walk on pasture, allowing freedom from discomfort and pain and the expression of normal behavior. This study examined the characteristics of locomotion behavior on pasture (gold standard with optimal locomotion comfort) and compared it with behaviors of cows walking on mastic asphalt or solid rubber mats before and after a routine claw trimming session. Our hypotheses were (1) that gait variables were different on pasture versus mastic asphalt and on mastic asphalt versus rubber, and (2) that claw trimming had an effect on gait variables of cows walking on mastic asphalt...
July 26, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28734628/adrenergic-receptor-genotypes-influence-postoperative-outcomes-in-infants-in-the-single-ventricle-reconstruction-trial
#14
Ronand Ramroop, George Manase, Danny Lu, Dorin Manase, Shan Chen, Richard Kim, Teresa Lee, William T Mahle, Kimberly McHugh, Mike Mitchell, Martin Tristani-Firouzi, Stephanie B Wechsler, Nicole S Wilder, Victor Zak, Myriam Lafreniere-Roula, Jane W Newburger, J William Gaynor, Mark W Russell, Seema Mital
OBJECTIVES: Adrenergic receptor (ADR) genotypes have been associated with adverse outcomes in heart failure. Our objective was to evaluate the association of ADR genotypes with post-Norwood outcomes in infants with hypoplastic left heart syndrome (HLHS). METHODS: Infants with HLHS participating in the Pediatric Heart Network Single-Ventricle Reconstruction Trial underwent genotyping for 4 single-nucleotide polymorphisms in 3 ADR genes: ADRB1_231A/G, ADRB1_1165G/C, ADRB2_5318C/G, and ADRA2A_2790C/T...
June 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28734623/eight-year-follow-up-of-the-clopidogrel-after-surgery-for-coronary-artery-disease-cascade-trial
#15
Ali Hage, Pierre Voisine, Fernanda Erthal, Éric Larose, David Glineur, Benjamin Chow, Hugo Tremblay, Jacqueline Fortier, Gifferd Ko, Dai Une, Michael Farkouh, Thierry G Mesana, Michel LeMay, Alexander Kulik, Marc Ruel
OBJECTIVE: In this 8 years' follow-up study, we evaluated the long-term outcomes of the addition of clopidogrel to aspirin during the first year after coronary artery bypass grafting, versus aspirin plus placebo, with respect to survival, major adverse cardiac, or major cerebrovascular events, including revascularization, functional status, graft patency, and native coronary artery disease progression. METHODS: In the initial Clopidogrel After Surgery for Coronary Artery Disease trial, 113 patients were randomized to receive either daily clopidogrel (n = 56) or placebo (n = 57), in addition to aspirin, in a double-blind fashion for 1 year after coronary artery bypass grafting...
June 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28729250/stellarex-drug-coated-balloon-for-treatment-of-femoropopliteal-disease-12-month-outcomes-from-the-randomized-illumenate-pivotal-and-pharmacokinetic-studies
#16
Prakash Krishnan, Peter Faries, Khusrow Niazi, Ash Jain, Ravish Sachar, William B Bachinsky, Joseph A Cardenas, Martin Werner, Marianne Brodmann, J A Mustapha, Carlos I Mena-Hurtado, Michael R Jaff, Andrew H Holden, Sean P Lyden
Background -Drug-coated balloons (DCB) are a predominant revascularization therapy for symptomatic femoropopliteal artery disease. Due to differences in excipients, paclitaxel dose and coating morphologies, varying clinical outcomes have been observed with different DCBs. We report the results of two studies investigating the pharmacokinetic (PK) and clinical outcomes of a new DCB to treat femoropopliteal disease. Methods -In the ILLUMENATE Pivotal Study, 300 symptomatic patients (Rutherford class 2-4), were randomized to DCB (N=200) or standard angioplasty (PTA) (N=100)...
July 20, 2017: Circulation
https://www.readbyqxmd.com/read/28724582/pretreatment-seizure-semiology-in-childhood-absence-epilepsy
#17
Sudha Kilaru Kessler, Shlomo Shinnar, Avital Cnaan, Dennis Dlugos, Joan Conry, Deborah G Hirtz, Fengming Hu, Chunyan Liu, Eli M Mizrahi, Solomon L Moshé, Peggy Clark, Tracy A Glauser
OBJECTIVE: To determine seizure semiology in children with newly diagnosed childhood absence epilepsy and to evaluate associations with short-term treatment outcomes. METHODS: For participants enrolled in a multicenter, randomized, double-blind, comparative-effectiveness trial, semiologic features of pretreatment seizures were analyzed as predictors of treatment outcome at the week 16 to 20 visit. RESULTS: Video of 1,932 electrographic absence seizures from 416 participants was evaluated...
July 19, 2017: Neurology
https://www.readbyqxmd.com/read/28723838/transcatheter-pulmonary-valve-implantation-valve-technology-and-procedural-outcome
#18
Arash Salavitabar, Patrick Flynn, Ralf J Holzer
PURPOSE OF REVIEW: Procedural technique and short-term outcomes of transcatheter pulmonary valve implantation (TPVI) have been widely described. The purpose of this article is to provide an update on current valve technology, and to focus on recent data surrounding TPVI in the dilated right ventricular outflow tract (RVOT), hybrid interventions, significant outcomes, and procedural costs. RECENT FINDINGS: Transcatheter valve technology has expanded with current trials evaluating self-expandable valves that can be implanted in dilated RVOTs...
July 18, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28721889/clinical-outcomes-of-large-brain-metastases-treated-with-neurosurgical-resection-and-intraoperative-cesium-131-brachytherapy-results-of-a-prospective-trial
#19
A Gabriella Wernicke, Cole B Hirschfeld, Andrew W Smith, Shoshana Taube, Menachem Z Yondorf, Bhupesh Parashar, Lucy Nedialkova, Fridon Kulidzhanov, Samuel Trichter, Albert Sabbas, Rohan Ramakrishna, Susan Pannullo, Theodore H Schwartz
PURPOSE: Studies on adjuvant stereotactic radiosurgery to the cavity of resected brain metastases have suggested that larger tumors (>2.0 cm) have greater rates of recurrence and radionecrosis (RN). The present study assessed the effect of permanent low-dose (131)Cs brachytherapy on local control and RN in patients treated for large brain metastases. METHODS AND MATERIALS: After institutional review board approval, 42 patients with 46 metastases ≥2.0 cm in preoperative diameter were accrued to a prospective trial from 2010 to 2015...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721881/final-report-of-a-prospective-randomized-trial-to-evaluate-the-dose-response-relationship-for-postoperative-radiation-therapy-and-pathologic-risk-groups-in-patients-with-head-and-neck%C3%A2-cancer
#20
RANDOMIZED CONTROLLED TRIAL
David I Rosenthal, Abdallah S R Mohamed, Adam S Garden, William H Morrison, Adel K El-Naggar, Mona Kamal, Randal S Weber, Clifton D Fuller, Lester J Peters
PURPOSE: To present the long-term and final report of a phase 3 trial designed to assess dose-response relationship for postoperative radiation therapy (PORT) and pathologic risk groups in head and neck cancer. METHODS AND MATERIALS: Patients who underwent primary surgery for American Joint Committee on Cancer stage III or IV squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx and who required PORT were eligible. Patients' primary sites and involved necks were independently assigned to higher- or lower-risk categories based on a cumulative point score representing increasing risk of recurrence...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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