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https://www.readbyqxmd.com/read/29157271/comparison-of-neoadjuvant-chemoradiation-with-carboplatin-paclitaxel-or-cisplatin-5-fluoruracil-in-patients-with-squamous-cell-carcinoma-of-the-esophagus
#1
Stefan Münch, Steffi U Pigorsch, Marcus Feith, Julia Slotta-Huspenina, Wilko Weichert, Helmut Friess, Stephanie E Combs, Daniel Habermehl
PURPOSE: Neoadjuvant chemoradiation (nCRT) is the treatment of choice for patients with locally advanced squamous cell carcinoma of the esophagus (SCC). Today radiation oncologists can choose between two different therapy regimes including chemoradiation with cisplatin and 5-fluoruracil (CDDP/5FU) and chemoradiation analogue to the CROSS-regime with carboplatin and paclitaxel (Carb/TAX). However, there is a lack of studies comparing these regimes, especially for the subgroup of patients with SCC...
November 21, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29156015/european-prospective-multicentre-study-of-hybrid-thoracoscopic-and-transcatheter-ablation-of-persistent-atrial-fibrillation-the-historic-af-trial
#2
Claudio Muneretto, Gianluigi Bisleri, Fabrizio Rosati, Ralf Krakor, Laura Giroletti, Lorenzo Di Bacco, Alberto Repossini, Massimo Moltrasio, Antonio Curnis, Claudio Tondo, Gianluca Polvani
OBJECTIVES: The HISTORIC-AF trial is a prospective, multicentre, single-arm study designed to evaluate the outcomes of a staged endoscopic and transcatheter ablation in patients with stand-alone, persistent or long-standing persistent atrial fibrillation (AF). METHODS: From 2012 to 2015, 100 consecutive patients were enrolled and underwent thoracoscopic left atrial epicardial isolation ('box lesion') followed by transcatheter ablation in case of AF recurrency. The safety end point was the composite outcome of freedom from major adverse events at 30-days, while efficacy end points were: (i) primary: freedom from AF and stable sinus rhythm following isolated thoracospic ablation >60% and (ii) secondary: freedom from AF and stable sinus rhythm >80% following hybrid ablation (as per HRS criteria)...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29141843/stable-sr-electrophysiological-substrate-ablation-in-the-left-atrium-during-sinus-rhythm-for-the-treatment-of-nonparoxysmal-atrial-fibrillation-a-prospective-multicenter-randomized-clinical-trial
#3
Bing Yang, Chenyang Jiang, Yazhou Lin, Gang Yang, Huimin Chu, Heng Cai, Fengmin Lu, Xianzhang Zhan, Jian Xu, Xinhua Wang, Chi-Keong Ching, Balbir Singh, Young-Hoon Kim, Minglong Chen
BACKGROUND: Circumferential pulmonary vein isolation (CPVI) alone or combined with adjuvant substrate modifications is unsatisfactory for atrial fibrillation (AF) control in nonparoxysmal AF patients. Ablation targeting the fibrotic areas after CPVI (STABLE-SR [Electrophysiological Substrate Ablation in the Left Atrium During Sinus Rhythm]) is a newly evolved substrate modification strategy. METHODS AND RESULTS: In this multicenter, randomized clinical trial, 229 symptomatic nonparoxysmal AF patients were 1:1 randomized to STABLE-SR group (n=114) or conventional STEPWISE group (n=115)...
November 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29141806/marked-neutropenia-significant-but-rare-in-people-with-multiple-sclerosis-after-alemtuzumab-treatment
#4
David Baker, Gavin Giovannoni, Klaus Schmierer
BACKGROUND: Alemtuzumab is a CD52-specific monoclonal antibody that markedly depletes T and B lymphocytes and inhibits relapsing multiple sclerosis (MS). However, polymorphonuclear neutrophils also express CD52 and can be depleted by alemtuzumab, thereby potentially contributing to the infections that develop post-alemtuzumab treatment. Surprisingly, however, the degree of neutrophil depletion in MS was not included in the pivotal trial reports. METHODS: The regulatory submission of the Comparison of Alemtuzumab and Rebif® Efficacy in MS 1 and 2 trials was obtained from the European Medicines Agency through Freedom of Information...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29122452/estimated-landmark-calibration-of-biomechanical-models-for-inverse-kinematics
#5
Ursula Trinler, Richard Baker
Inverse kinematics is emerging as the optimal method in movement analysis to fit a multi-segment biomechanical model to experimental marker positions. A key part of this process is calibrating the model to the dimensions of the individual being analysed which requires scaling of the model, pose estimation and localisation of tracking markers within the relevant segment coordinate systems. The aim of this study is to propose a generic technique for this process and test a specific application to the OpenSim model Gait2392...
November 6, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29117818/one-year-outcomes-following-directional-atherectomy-of-popliteal-artery-lesions-subgroup-analysis-of-the-prospective-multicenter-definitive-le-trial
#6
Aljoscha Rastan, James F McKinsey, Lawrence A Garcia, Krishna J Rocha-Singh, Michael R Jaff, Stuart Harlin, Suraj Kamat, Sean Janzer, Thomas Zeller
PURPOSE: To report the effectiveness of directional atherectomy for the treatment of popliteal artery occlusive disease. METHODS: This subset of the prospective, multicenter, single-arm DEFINITIVE LE trial included 158 patients (mean age 72.0±10.9 years; 82 men) who underwent directional atherectomy in 162 popliteal artery lesions between 2009 and 2011. Forty-eight (30.4%) patients were suffering from critical limb ischemia (CLI). The mean lesion length was 5.8±3...
November 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29112886/uncontrolled-manifold-analysis-of-joint-angle-variability-during-table-tennis-forehand
#7
Yoichi Iino, Shinsuke Yoshioka, Senshi Fukashiro
This study was conducted with the objective of evaluating the variance structure of the trunk and racket arm joint angles in table tennis topspin forehand using the uncontrolled manifold (UCM) approach, regarding racket orientation as the task variable. Nine advanced and eight intermediate male collegiate table tennis players performed the topspin strokes against backspin balls. The trunk, upper limb, and racket were modeled as six rigid-link segments with a total of 16 rotation degrees of freedom. The UCM analysis was conducted using 30 trial datasets per participant to quantify the degree of redundancy exploitation needed to stabilize the vertical and horizontal angles of the racket...
November 4, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29108137/multi-arm-trials-with-multiple-primary-endpoints-and-missing-values
#8
Mario Hasler, Ludwig A Hothorn
We present an extension of multiple contrast tests for multiple endpoints to the case of missing values. The endpoints are assumed to be normally distributed and correlated and to have equal covariance matrices for the different treatments. Different multivariate t distributions will be applied, differing in endpoint-specific degrees of freedom. In contrast to competing methods, the familywise error type I is maintained in the strong sense in an admissible range, and the problem of different marginal errors type I is avoided...
November 6, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29105841/vertebral-fractures-following-discontinuation-of-denosumab-a-post-hoc-analysis-of-the-randomized-placebo-controlled-freedom-trial-and-its-extension
#9
Steven R Cummings, Serge Ferrari, Richard Eastell, Nigel Gilchrist, Jens-Erik Beck Jensen, Michael McClung, Christian Roux, Ove Törring, Ivo Valter, Andrea T Wang, Jacques P Brown
Denosumab reduces bone resorption and vertebral and nonvertebral fracture risk. Denosumab discontinuation increases BTMs 3 months after a scheduled dose is omitted, reaching above-baseline levels by 6 months, and decreases BMD to baseline levels by 12 months. We analyzed the risk of new or worsening vertebral fractures, especially multiple vertebral fractures, in participants who discontinued denosumab during the FREEDOM study or its Extension. Participants received ≥2 doses of denosumab or placebo Q6M, discontinued treatment, and stayed in the study ≥7 months after the last dose...
November 4, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29102437/drug-eluting-stents-versus-coronary-artery-bypass-grafts-for-left-main-coronary-disease-a-meta-analysis-and-review-of-randomised-controlled-trials
#10
Peter Moore, Matthew Burrage, Paul Garrahy, Richard Lim, Andrew McCann, Anthony Camuglia
BACKGROUND: Revascularisation of left main coronary artery (LMCA) disease can be potentially managed with percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). Recent randomised controlled trial (RCT) data have added to the literature on this subject and this meta-analysis aims to assess the state of the data to assist in guiding patient treatment decisions. METHODS: A systematic literature search of Cochrane Library, Embase, OVID, and PubMed MEDLINE was performed...
October 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29100704/effect-of-technique-on-outcomes-following-bioresorbable-vascular-scaffold%C3%A2-implantation-analysis-from-the-absorb-trials
#11
Gregg W Stone, Alexandre Abizaid, Yoshinobu Onuma, Ashok Seth, Runlin Gao, John Ormiston, Takeshi Kimura, Bernard Chevalier, Ori Ben-Yehuda, Ovidiu Dressler, Tom McAndrew, Stephen G Ellis, Dean J Kereiakes, Patrick W Serruys
BACKGROUND: Procedural technique may affect clinical outcomes after bioresorbable vascular scaffold (BVS) implantation. Prior studies suggesting such a relationship have not adjusted for baseline patient and lesion characteristics that may have influenced operator choice of technique and outcomes. OBJECTIVES: This study sought to determine whether target lesion failure (TLF) (cardiac death, target-vessel myocardial infarction, or ischemia-driven target lesion revascularization) and scaffold thrombosis (ScT) rates within 3 years of BVS implantation are affected by operator technique (vessel size selection and pre- and post-dilation parameters)...
October 20, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29090661/patent-foramen-ovale-closure-with-gore-helex-or-cardioform-septal-occluder-vs-antiplatelet-therapy-for-reduction-of-recurrent-stroke-or-new-brain-infarct-in-patients-with-prior-cryptogenic-stroke-design-of-the-randomized-gore-reduce-clinical-study
#12
Scott E Kasner, Lars Thomassen, Lars Søndergaard, John F Rhodes, Coby C Larsen, Joth Jacobson
Rationale The utility of patent foramen ovale (PFO) closure for secondary prevention in patients with prior cryptogenic stroke is uncertain despite multiple randomized trials completed to date. Aims The Gore REDUCE Clinical Study (REDUCE) aims to establish superiority of patent foramen ovale closure in conjunction with antiplatelet therapy over antiplatelet therapy alone in reducing the risk of recurrent clinical ischemic stroke or new silent brain infarct in patients who have had a cryptogenic stroke. Methods and design This controlled, open-label trial randomized 664 subjects with cryptogenic stroke at 63 multinational sites in a 2:1 ratio to either antiplatelet therapy plus patent foramen ovale closure (with GORE® HELEX® Septal Occluder or GORE® CARDIOFORM Septal Occluder) or antiplatelet therapy alone...
December 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29089197/the-fastest-field-sport-in-the-world-a-case-report-on-3-dimensional-printed-hurling-gloves-to-help-prevent-injury
#13
Daniel Harte, Abby Paterson
STUDY DESIGN: Case series. INTRODUCTION: Hand injuries are the most common injury observed in hurling although compliance in wearing protective gloves is reportedly low. PURPOSE OF THE STUDY: To devise a glove that offers comfort, protection and freedom of movement, using the bespoke capabilities of 3-dimensional (3D) printing. METHODS: Each player's "catching" hand was imaged using a 3D scanner to produce a bespoke glove that they later trialed and provided feedback...
October 28, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29081743/the-propagation-of-movement-variability-in-time-a-methodological-approach-for-discrete-movements-with-multiple-degrees-of-freedom
#14
Melanie Krüger, Andreas Straube, Thomas Eggert
In recent years, theory-building in motor neuroscience and our understanding of the synergistic control of the redundant human motor system has significantly profited from the emergence of a range of different mathematical approaches to analyze the structure of movement variability. Approaches such as the Uncontrolled Manifold method or the Noise-Tolerance-Covariance decomposition method allow to detect and interpret changes in movement coordination due to e.g., learning, external task constraints or disease, by analyzing the structure of within-subject, inter-trial movement variability...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29081351/integrating-biological-treatment-mechanisms-into-randomized-clinical-trials-design-of-progress-prolonged-exposure-and-sertraline-trial
#15
Sheila A M Rauch, Naomi M Simon, H Myra Kim, Ron Acierno, Anthony P King, Sonya B Norman, Margaret R Venners, Katherine Porter, K Luan Phan, Peter W Tuerk, Carolyn Allard, Israel Liberzon, Barbara O Rothbaum, Brian Martis, Murray B Stein, Charles W Hoge
Increased emphasis on mechanisms of treatment effectiveness, biomarker predictors, and objective indicators of treatment response has sparked interest in integrated, translational treatment outcomes trials. The PROlonGed ExpoSure and Sertraline Trial (PROGrESS) is one such randomized controlled trial (RCT) focused on a key question in clinical management of posttraumatic stress disorder (PTSD) - the comparative and combined effectiveness of medication and psychotherapy. PROGrESS employs a state of the art trial design to examine psychotherapy and medication effects across three conditions: 1) Prolonged Exposure (PE) plus pill placebo, 2) Sertraline (SERT) plus Enhanced Medication Management (EMM), and 3) Combined treatment (PE/SERT)...
October 29, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29078242/-drug-coated-balloon-angioplasty-in-femoropopliteal-arteries-is-there-a-class-effect
#16
Ulf Karl-Martin Teichgräber, Christof Klumb
Aim Percutaneous transluminal angioplasty (PTA) is a well-accepted method to re-establish patency in stenotic and reoccluded vessels. One tool to improve results may be to use paclitaxel drug-coated balloon (DCB) catheters. This systematic review investigates whether there is a class effect among different DCBs. Methods The primary endpoint was "Freedom from Target Lesion Revascularisation" (FfTLR) after 12 months. A systematic literature search was performed in PubMed and risk of bias was assessed of the included trials...
October 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29075979/second-generation-cryoballoon-ablation-for-persistent-atrial-fibrillation-an-updated-meta-analysis
#17
Hazem Omran, Klaus-Jürgen Gutleben, Stephan Molatta, Thomas Fischbach, Birgit Wellmann, Dieter Horstkotte, Britta Körber, Georg Nölker
BACKGROUND: Catheter ablation is an established treatment option for patients with symptomatic atrial fibrillation (AF). The cornerstone of AF ablation is pulmonary vein isolation (PVI). The second-generation cryoballoon (2G-CB) has shown non-inferiority to radiofrequency (RF) ablation in paroxysmal AF in several trials. Growing evidence suggests that 2G-CB is also effective in patients with persistent AF (perAF). The aim of this study was to summarize and analyze available data on safety and mid-term (≥ 12 months) efficacy of PVI using 2G-CB in patients with perAF...
October 26, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29069568/surgery-for-drug-resistant-epilepsy-in-children
#18
RANDOMIZED CONTROLLED TRIAL
Rekha Dwivedi, Bhargavi Ramanujam, P Sarat Chandra, Savita Sapra, Sheffali Gulati, Mani Kalaivani, Ajay Garg, Chandra S Bal, Madhavi Tripathi, Sada N Dwivedi, Rajesh Sagar, Chitra Sarkar, Manjari Tripathi
BACKGROUND: Neurosurgical treatment may improve seizures in children and adolescents with drug-resistant epilepsy, but additional data are needed from randomized trials. METHODS: In this single-center trial, we randomly assigned 116 patients who were 18 years of age or younger with drug-resistant epilepsy to undergo brain surgery appropriate to the underlying cause of epilepsy along with appropriate medical therapy (surgery group, 57 patients) or to receive medical therapy alone (medical-therapy group, 59 patients)...
October 26, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29067682/eslicarbazepine-acetate-add-on-for-drug-resistant-partial-epilepsy
#19
REVIEW
Xian-Chao Chang, Hai Yuan, Yi Wang, Hui-Qin Xu, Wen-Ke Hong, Rong-Yuan Zheng
BACKGROUND: This is an updated version of the Cochrane Review published in the Cochrane Library 2011, Issue 12.The majority of people with epilepsy have a good prognosis, but up to 30% of people continue to have seizures despite several regimens of antiepileptic drugs. In this review, we summarized the current evidence regarding eslicarbazepine acetate (ESL) when used as an add-on treatment for drug-resistant partial epilepsy. OBJECTIVES: To evaluate the efficacy and tolerability of ESL when used as an add-on treatment for people with drug-resistant partial epilepsy...
October 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29066244/reliability-of-assessing-postural-control-during-seated-balancing-using-a-physical-human-robot-interaction
#20
Ahmed Ramadan, Jacek Cholewicki, Clark J Radcliffe, John M Popovich, N Peter Reeves, Jongeun Choi
This study evaluated the within- and between-visit reliability of a seated balance test for quantifying trunk motor control using input-output data. Thirty healthy subjects performed a seated balance test under three conditions: eyes open (EO), eyes closed (EC), and eyes closed with vibration to the lumbar muscles (VIB). Each subject performed three trials of each condition on three different visits. The seated balance test utilized a torque-controlled robotic seat, which together with a sitting subject resulted in a physical human-robot interaction (pHRI) (two degrees-of-freedom with upper and lower body rotations)...
October 7, 2017: Journal of Biomechanics
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