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Freedom trial

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https://www.readbyqxmd.com/read/27926827/decoding-hand-gestures-from-primary-somatosensory-cortex-using-high-density-ecog
#1
Mariana P Branco, Zachary V Freudenburg, Erik J Aarnoutse, Martin G Bleichner, Mariska J Vansteensel, Nick F Ramsey
Electrocorticography (ECoG) based Brain-Computer Interfaces (BCIs) have been proposed as a way to restore and replace motor function or communication in severely paralyzed people. To date, most motor-based BCIs have either focused on the sensorimotor cortex as a whole or on the primary motor cortex (M1) as a source of signals for this purpose. Still, target areas for BCI are not confined to M1, and more brain regions may provide suitable BCI control signals. A logical candidate is the primary somatosensory cortex (S1), which not only shares similar somatotopic organization to M1, but also has been suggested to have a role beyond sensory feedback during movement execution...
December 4, 2016: NeuroImage
https://www.readbyqxmd.com/read/27924754/relevance-of-randomised-controlled-trials-in-oncology
#2
REVIEW
Ian F Tannock, Eitan Amir, Christopher M Booth, Saroj Niraula, Alberto Ocana, Bostjan Seruga, Arnoud J Templeton, Francisco Vera-Badillo
Well-designed randomised controlled trials (RCTs) can prevent bias in the comparison of treatments and provide a sound basis for changes in clinical practice. However, the design and reporting of many RCTs can render their results of little relevance to clinical practice. In this Personal View, we discuss the limitations of RCT data and suggest some ways to improve the clinical relevance of RCTs in the everyday management of patients with cancer. RCTs should ask questions of clinical rather than commercial interest, avoid non-validated surrogate endpoints in registration trials, and have entry criteria that allow inclusion of all patients who are fit to receive treatment...
December 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27923379/schoolgirls-experience-and-appraisal-of-menstrual-absorbents-in-rural-uganda-a-cross-sectional-evaluation-of-reusable-sanitary-pads
#3
Julie Hennegan, Catherine Dolan, Maryalice Wu, Linda Scott, Paul Montgomery
BACKGROUND: Governments, multinational organisations, and charities have commenced the distribution of sanitary products to address current deficits in girls' menstrual management. The few effectiveness studies conducted have focused on health and education outcomes but have failed to provide quantitative assessment of girls' preferences, experiences of absorbents, and comfort. Objectives of the study were, first, to quantitatively describe girls' experiences with, and ratings of reliability and acceptability of different menstrual absorbents...
December 7, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27919491/comparing-outcomes-from-clinical-studies-of-oral-disease-modifying-therapies-dimethyl-fumarate-fingolimod-and-teriflunomide-in-relapsing-ms-assessing-absolute-differences-using-a-number-needed-to-treat-analysis
#4
Mark S Freedman, Xavier Montalban, Aaron E Miller, Catherine Dive-Pouletty, Steven Hass, Karthinathan Thangavelu, Thomas P Leist
Dimethyl fumarate (DMF), fingolimod, and teriflunomide are oral disease-modifying therapies (DMTs) indicated for the treatment of relapsing-remitting multiple sclerosis. Despite well-established limitations of cross-trial comparisons, DMTs are still frequently compared in terms of relative reductions in specific endpoints, most commonly annualized relapse rate. Consideration of absolute risk reduction and number needed to treat (NNT) provides an alternative approach to assess the magnitude of treatment effect and can provide valuable additional information on therapeutic gain...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27916374/transfer-and-priming-of-surgical-skills-across-minimally-invasive-surgical-platforms
#5
Ahmed Zihni, Tianjia Ge, Shuddhadeb Ray, Robert Wang, Zhe Liang, Jaime A Cavallo, Michael M Awad
BACKGROUND: Robot-assisted laparoscopic surgery (RALS) uses 3-dimensional visualization and wristed instruments that provide more degrees of freedom than rigid traditional laparoscopic (TLS) instrumentation. These features have been touted to improve accuracy and efficiency during surgical task performance. Little is known, however, about the transferability of skills between the two platforms or whether task performance on one platform primes surgeons for task performance on the other...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27915111/clinical-outcomes-of-perampanel-vs-lacosamide-in-cohorts-of-consecutive-patients-with-severely-refractory-epilepsies-a-monocentric-retrospective-analysis-of-systematically-collected-data-from-the-german-kork-epilepsy-center
#6
Christoph Kurth, Edgar Kockelmann, Bernhard J Steinhoff
PURPOSE: Perampanel (PER) and lacosamide (LCM) are antiepileptic drugs (AEDs) approved for the adjunctive treatment of partial-onset seizures. At the time of market entry, information on clinical effectiveness of new AEDs is limited to results from pivotal trials, real-life or comparative data are missing. This analysis of data collected retrospectively in a German epilepsy center used unified evaluation criteria, and describes treatment outcomes with LCM and PER at 6 months. METHODS: Results of the first 70 consecutive patients who had received LCM or PER after their market entries in Germany were compared...
November 23, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27910087/menstrual-migraine-and-treatment-options-review
#7
REVIEW
Kasra Maasumi, Stewart J Tepper, Jennifer S Kriegler
OBJECTIVE: A review of treatment options for menstrual migraine. BACKGROUND: Migraine affects ∼30 million people in the US. A subset of female migraineurs have migraines that are mainly associated with menstruation. Menstrual migraine (MM) is divided into pure MM and menstrually related migraine. Pure MM attacks occur only with menstruation and have a prevalence of 1%. Menstrually related migraine has a prevalence of 6-7%, and occurs both during menstruation as well as during the rest of the cycle...
December 2, 2016: Headache
https://www.readbyqxmd.com/read/27909748/temporal-prediction-abilities-are-mediated-by-motor-effector-and-rhythmic-expertise
#8
Fiona C Manning, Jennifer Harris, Michael Schutz
Motor synchronization is a critical part of musical performance and listening. Recently, motor control research has described how movements that contain more available degrees of freedom are more accurately timed. Previously, we demonstrated that stick tapping improves perception in a timing detection task, where percussionists greatly outperformed non-percussionists only when tapping along. Since most synchronization studies implement finger tapping to examine simple motor synchronization, here we completed a similar task where percussionists and non-percussionists synchronized using finger tapping; movement with fewer degrees of freedom than stick tapping...
December 1, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27898215/randomized-trial-of-pleural-fluid-drainage-frequency-in-patients-with-malignant-pleural-effusions-the-asap-trial
#9
Momen M Wahidi, Chakravarthy Reddy, Lonny Yarmus, David Feller-Kopman, Ali Musani, R Wesley Shepherd, Hans Lee, Rabih Bechara, Carla Lamb, Scott Shofer, Kamran Mahmood, Gaetane Michaud, Jonathan Puchalski, Samaan Rafeq, Stephen M Cattaneo, John Mullon, Steven Leh, Martin Mayse, Samantha M Thomas, Bercedis Peterson, Richard W Light
RATIONALE: Patients with malignant pleural effusions have significant dyspnea and shortened life expectancy. Indwelling pleural catheters (IPC) allow patients to drain pleural fluid at home and can lead to auto-pleurodesis. The optimal drainage frequency to achieve auto-pleurodesis and freedom from catheter has not been determined. OBJECTIVE: To determine whether an aggressive daily drainage strategy is superior to the current standard every other day drainage of pleural fluid in achieving auto-pleurodesis...
November 29, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27896556/towards-standardized-automated-immunomonitoring-an-automated-elispot-assay-for-safe-and-parallelized-functionality-analysis-of-immune-cells
#10
J C Neubauer, I Sébastien, A Germann, S C Müller, A Meyerhans, H von Briesen, H Zimmermann
The ELISpot assay is used for the detection of T cell responses in clinical trials and vaccine evaluations. Standardization and reproducibility are necessary to compare the results worldwide, inter- and intra-assay variability being critical factors. To assure operator safety as well as high-quality experiment performance, the ELISpot assay was implemented on an automated liquid handling platform, a Tecan Freedom EVO. After validation of the liquid handling, automated loading of plates with cells and reagents was investigated...
November 28, 2016: Cytotechnology
https://www.readbyqxmd.com/read/27896226/use-of-the-directional-atherectomy-for-the-treatment-of-femoro-popliteal-lesions-in-patients-with-critical-lower-limb-ischemia
#11
Umberto Marcello Bracale, Gaetano Vitale, Guido Bajardi, Donatella Narese, Ettore Dinoto, Anna Maria Giribono, Doriana Ferrara, Luca Del Guercio, Massimo Midiri, Felice Pecoraro
: Femoro-popliteal PTA for the treatment of critical limb ischemia is frequently associated with unsatisfactory procedural success rates while directional atherectomy (DCA) has improved success rate since claudicant patients undergoing percutaneous treatment of femoro-popliteal obstructive disease. The aim of this prospective study is to evaluate the safety, efficacy and procedural success of DCA, at one year, in the percutaneous treatment of femoro-popliteal obstructive disease in patients with critical limb ischemia...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27890526/femoropopliteal-in-stent-restenosis-repair-midterm-outcomes-after-paclitaxel-eluting-balloon-use-plaisir-trial
#12
N Bague, P Julia, A Sauguet, J M Pernès, P Chatelard, J F Garbé, S Penillon, J M Cardon, P Commeau, O Planché, B Guyomarch, Y Gouëffic
OBJECTIVE: The aim was to assess 18 month outcomes of the paclitaxel eluting balloon (PEB) in patients with femoropopliteal (FP) in-stent restenosis (ISR). METHODS: In a national prospective and multicentre cohort study, symptomatic patients with femoropopliteal in-stent restenosis were included from January 2012 to June 2013. Patients were treated by paclitaxel eluting balloon angioplasty (In Pact Admiral, Medtronic, Santa Rosa, CA, USA). Clinical and duplex scan follow-up evaluations were performed at 1, 3, 6, 9, 12, and 18 months...
November 24, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27889444/the-effectiveness-of-emotional-freedom-techniques-in-the-treatment-of-posttraumatic-stress-disorder-a-meta-analysis
#13
REVIEW
Brenda Sebastian, Jerrod Nelms
BACKGROUND: Over the past two decades, growing numbers of clinicians have been utilizing emotional freedom techniques (EFT) in the treatment of posttraumatic stress disorder (PTSD), anxiety, and depression. Randomized controlled trials (RCTs) have shown encouraging outcomes for all three conditions. OBJECTIVE: To assess the efficacy of EFT in treating PTSD by conducting a meta-analysis of existing RCTs. METHODS: A systematic review of databases was undertaken to identify RCTs investigating EFT in the treatment of PTSD...
October 24, 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/27889242/benign-mesial-temporal-lobe-epilepsy-a-clinical-cohort-and-literature-review
#14
REVIEW
Amal AlQassmi, Jorge G Burneo, Richard S McLachlan, Seyed M Mirsattari
OBJECTIVE: We present a single-center retrospective study of benign mesial temporal lobe epilepsy (bMTLE) between 1995 and 2014. METHODS: Hospital records and clinic charts were reviewed. The clinical, Eelectroencephalographic (EEG), imaging features, and response to treatment with antiepileptic drugs (AEDs) were documented. Patients were included in this study if they were seizure-free for a minimum of 24months with or without an AED. RESULTS: Twenty-seven patients were identified...
November 23, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27871122/efficacy-and-safety-of-ablation-for-people-with-non-paroxysmal-atrial-fibrillation
#15
REVIEW
Jonathan Nyong, Guy Amit, Alma J Adler, Onikepe O Owolabi, Pablo Perel, David Prieto-Merino, Pier Lambiase, Juan Pablo Casas, Carlos A Morillo
BACKGROUND: The optimal rhythm management strategy for people with non-paroxysmal (persistent or long-standing persistent) atrial fibrilation is currently not well defined. Antiarrhythmic drugs have been the mainstay of therapy. But recently, in people who have not responded to antiarrhythmic drugs, the use of ablation (catheter and surgical) has emerged as an alternative to maintain sinus rhythm to avoid long-term atrial fibrillation complications. However, evidence from randomised trials about the efficacy and safety of ablation in non-paroxysmal atrial fibrillation is limited...
November 22, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27861188/controversies-in-quantification-of-mitral-valve-regurgitation-role-of-cardiac-magnetic-resonance-imaging
#16
Kim A Connelly, Edwin C Ho, Howard Leong-Poi
PURPOSE OF REVIEW: Mitral regurgitation remains a common problem, and when severe, is associated with significant morbidity and mortality. At present, echocardiography remains the primary modality for assessing both mechanism and severity of mitral regurgitation. However, recent studies demonstrate that the echocardiographic assessment of mitral regurgitation severity may be subject to variability as a result of semiquantitative parameters, dependence upon loading conditions and significant interobserver variability...
November 18, 2016: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27843054/a-systematic-review-and-meta-analysis-of-randomized-and-nonrandomized-trials-of-clinical-emotional-freedom-techniques-eft-for-the-treatment-of-depression
#17
Jerrod A Nelms, Liana Castel
BACKGROUND: Among a group of therapies collectively known as energy psychology (EP), emotional freedom techniques (EFT) is the most widely practiced. Clinical EFT is an evidence-based practice combining elements of cognitive and exposure therapies with the manual stimulation of acupuncture points (acupoints). Lacking is a recent quantitative meta-analysis that enhances understanding of the variability and clinical significance of outcomes after clinical EFT treatment in reducing depression...
November 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/27822454/report-on-first-international-workshop-on-robotic-surgery-in-thoracic-oncology
#18
Giulia Veronesi, Robert Cerfolio, Roberto Cingolani, Jens C Rueckert, Luc Soler, Alper Toker, Umberto Cariboni, Edoardo Bottoni, Uberto Fumagalli, Franca Melfi, Carlo Milli, Pierluigi Novellis, Emanuele Voulaz, Marco Alloisio
A workshop of experts from France, Germany, Italy, and the United States took place at Humanitas Research Hospital Milan, Italy, on February 10 and 11, 2016, to examine techniques for and applications of robotic surgery to thoracic oncology. The main topics of presentation and discussion were robotic surgery for lung resection; robot-assisted thymectomy; minimally invasive surgery for esophageal cancer; new developments in computer-assisted surgery and medical applications of robots; the challenge of costs; and future clinical research in robotic thoracic surgery...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27819760/reversible-cerebral-vasoconstriction-syndrome-in-association-with-fingolimod-use
#19
Scott Belliston, Jayshree Sundararajan, Kathy Newell, Sharon Lynch
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS), also known as Call-Fleming syndrome, is characterized by thunderclap headaches, non-aneurysmal segmental cerebral vasoconstriction seen on arteriogram, and spontaneously resolves within twelve weeks. Fingolimod has been reported to cause posterior reversible encephalopathy syndrome (PRES) and one case of RCVS. OBJECTIVE: We report a case of RCVS possibly related to fingolimod use, and compare to cases of adverse outcomes in fingolimod use...
November 7, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27818704/corrigendum-to-anxiety-and-anger-symptoms-in-hwabyung-patients-improved-more-following-4-weeks-of-the-emotional-freedom-technique-program-compared-to-the-progressive-muscle-relaxation-program-a-randomized-controlled-trial
#20
Jin Woo Suh, Sun Yong Chung, Sang Young Kim, Jung Hwan Lee, Jong Woo Kim
[This corrects the article DOI: 10.1155/2015/203612.].
2016: Evidence-based Complementary and Alternative Medicine: ECAM
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