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https://www.readbyqxmd.com/read/28076633/statins-for-aortic-valve-stenosis
#1
Luciana Thiago, Selma Rumiko Tsuji, Jonathan Nyong, Maria Eduarda Dos Santos Puga, Aécio Flávio Teixeira de Góis, Cristiane Rufino Macedo, Orsine Valente, Álvaro Nagib Atallah
BACKGROUND: Aortic valve stenosis is the most common type of valvular heart disease in the USA and Europe. Aortic valve stenosis is considered similar to atherosclerotic disease. Some studies have evaluated statins for aortic valve stenosis. OBJECTIVES: To evaluate the effectiveness and safety of statins in aortic valve stenosis. METHODS: Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, LILACS - IBECS, Web of Science and CINAHL Plus...
November 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28069073/quantification-of-postural-stability-in-minimally-disabled-multiple-sclerosis-patients-by-means-of-dynamic-posturography-an-observational-study
#2
Lucia Grassi, Stefano Rossi, Valeria Studer, Gessica Vasco, Caterina Motta, Fabrizio Patanè, Enrico Castelli, Silvia Rossi, Paolo Cappa
BACKGROUND: Multiple Sclerosis (MS) is a widespread progressive neurologic disease with consequent impairments in daily activities. Disorders of balance are frequent and equilibrium tests are potentially useful to quantify disability and to verify treatment effectiveness. The fair sensitivity of the widely used not-perturbed tests to detect balance disturbances in MS patients have prompted the development of mechatronic systems capable to impose known equilibrium perturbations, in order to challenge the balance control and, consequently, to better assess the level of impairment...
January 10, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28064433/magnetic-vt-study-a-prospective-multicenter-post-market-randomized-controlled-trial-comparing-vt-ablation-outcomes-using-remote-magnetic-navigation-guided-substrate-mapping-and-ablation-versus-manual-approach-in-a-low-lvef-population
#3
Luigi Di Biase, Roderick Tung, Tamás Szili-Torok, J David Burkhardt, Peter Weiss, Rene Tavernier, Adam E Berman, Erik Wissner, William Spear, Xu Chen, Petr Neužil, Jan Skoda, Dhanunjaya Lakkireddy, Bruno Schwagten, Ken Lock, Andrea Natale
PURPOSE: Patients with ischemic cardiomyopathy (ICM) are prone to scar-related ventricular tachycardia (VT). The success of VT ablation depends on accurate arrhythmogenic substrate localization, followed by optimal delivery of energy provided by constant electrode-tissue contact. Current manual and remote magnetic navigation (RMN)-guided ablation strategies aim to identify a reentry circuit and to target a critical isthmus through activation and entrainment mapping during ongoing tachycardia...
January 7, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28047178/th-ab-202-12-the-first-clinical-implementation-of-a-real-time-six-degree-of-freedom-tracking-system-during-radiation-therapy
#4
D Nguyen, J Kim, R O'Brien, C Huang, J Booth, P Greer, K Legge, P Poulsen, J Martin, P Keall
PURPOSE: In current practice, imaging is typically performed prior to treatment; the cancer target motion during treatment is unknown. We present the first clinical implementation of real time Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during treatment. METHODS: KIM technology: KIM estimates the 3D position of the target tumour based on segmented 2D positions of the three implanted fiducials in each of the kV images (125 kV, 10 mA at 11 fps) taken continuously during the treatment arc...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043438/surgical-experience-and-long-term-results-of-baroreflex-activation-therapy-for-heart-failure-with-reduced-ejection-fraction
#5
Fred A Weaver, William T Abraham, William C Little, Christian Butter, Anique Ducharme, Marcel Halbach, Didier Klug, Eric G Lovett, Navid Madershahian, Jochen Müller-Ehmsen, Jill E Schafer, Michele Senni, Vijay Swarup, Rolf Wachter, Michael R Zile
The purpose of this publication is to describe the intraoperative experience along with long-term safety and efficacy of the second-generation baroreflex activation therapy (BAT) system in patients with heart failure (HF) and reduced ejection fraction HF (HFrEF). In a randomized trial of New York Heart Association Class III HFrEF, 140 patients were assigned 1:1 to receive BAT plus medical therapy or medical therapy alone. Procedural information along with safety and efficacy data were collected and analyzed over 12 months...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28011328/impact-of-acute-atrial-fibrillation-af-termination-and-prolongation-of-af-cycle-length-afcl-on-the-outcome-of-ablation-of-persistent-af-a-sub-study-of-the-star-af-ii-trial
#6
Simon Kochhäuser, Chen-Yang Jiang, Timothy R Betts, Jian Chen, Isabel Deisenhofer, Roberto Mantovan, Laurent Macle, Carlos A Morillo, Wilhelm Haverkamp, Rukshen Weerasooriya, Jean-Paul Albenque, Stefano Nardi, Endrj Menardi, Paul Novak, Prashanthan Sanders, Atul Verma
BACKGROUND: There is controversy about the impact of acute AF termination and prolongation of AFCL during ablation on the long-term procedural outcome. OBJECTIVE: We analyzed the influence of AF termination and AFCL-prolongation on freedom from AF in patients from the STAR-AF II trial. METHODS: Acute changes in AFCL and AF termination were collected during the index procedure of the STAR-AF II trial and compared to recurrence of AF at 18 months...
December 20, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28007058/the-50-50-cc-total-artificial-heart-trial-extending-the-benefits-of-the-total-artificial-heart-to-underserved-populations
#7
REVIEW
Dennis Wells, Chet R Villa, David Luís Simón Morales
While use of the total artificial heart (TAH) is growing, the use of the device is not uniform across the gender and age spectrum because the vast majority of implants are in adult males. SynCardia has recently developed a smaller 50 cc TAH that was designed to accommodate patients with a body surface area as low as 1.2 m(2) (potentially even lower using virtual implantation). Herein, we describe the early use of the 50 cc TAH (10 implants in the US and 18 outside the US). Twenty-eight devices have been implanted worldwide...
January 2017: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://www.readbyqxmd.com/read/28004518/reinventing-design-principles-for-developing-low-viscosity-carbon-dioxide-binding-organic-liquids-co2bols-for-flue-gas-clean-up
#8
Phillip Koech, Deepika Malhotra, David J Heldebrant, David C Cantu, Feng Zheng, Vassiliki-Alexandra Glezakou, Roger Rousseau
Anthropogenic carbon dioxide (CO2) emissions from point sources account for the majority of greenhouse gases in the atmosphere. Capture and storage are required to mitigate adverse environmental effects. Aqueous amine-based solvents are currently considered the industry standard, but deployment to market is limited by their high regeneration energy. In that context, water-lean solvent systems such as CO2 binding organic liquids (CO2BOLs) are being developed to reduce this energy requirement for CO2 capture...
December 21, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27998964/phase-2-placebo-controlled-double-blind-trial-of-dasatinib-added-to-gemcitabine-for-patients-with-locally-advanced-pancreatic-cancer
#9
T R J Evans, E Van Cutsem, M J Moore, I S Bazin, A Rosemurgy, G Bodoky, G Deplanque, M Harrison, B Melichar, D Pezet, A Elekes, E Rock, C Lin, L Strauss, P J O'Dwyer
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate with limited treatment options. Gemcitabine provides a marginal survival benefit for patients with advanced PDAC. Dasatinib is a competitive inhibitor of Src kinase, which is overexpressed in PDAC tumors. Dasatinib and gemcitabine were combined in a phase 1 clinical trial where stable disease was achieved in 2 of 8 patients with gemcitabine-refractory PDAC. PATIENTS AND METHODS: This placebo-controlled, randomized, double-blind, phase II study compared the combination of gemcitabine plus dasatinib to gemcitabine plus placebo in patients with locally advanced, non-metastatic PDAC...
December 19, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27998049/long-term-results-of-outside-instructions-for-use-evar
#10
José Oliveira-Pinto, Nelson Oliveira, Frederico Bastos-Gonçalves, Sanne Hoeks, Marie J VAN Rijn, Sander Ten Raa, Armando Mansilha, Hence J Verhagen
BACKGROUNG: Endovascular aneurysm repair (EVAR) has progressively expanded to more complex anatomies, frequently outside manufacturer's instructions for use (IFU). However, the long term results of off-label use of EVAR remains largely undocumented. The aim of this paper is to examine the long term results of outside IFU EVAR. METHODS: English literature was searched to identify publications on long term results for outside IFU EVAR. A follow-up extending for at least 5 years was the minimum required as inclusion criteria...
December 19, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27995554/a-randomized-trial-to-assess-the-contribution-of-a-novel-thorax-support-vest-corset-in-preventing-mechanical-complications-of-median-sternotomy
#11
Philippe P Caimmi, Maurizio Sabbatini, Emmanouil I Kapetanakis, Silvia Cantone, Marcus V Ferraz, Mario Cannas, Ugo F Tesler
OBJECTIVES: Mechanical complications of median sternotomy may cause significant morbidity and mortality in cardiac surgical patients. This study was aimed at assessing the role of Posthorax support vest (Epple, Inc., Vienna, Austria) in the prevention of sternal complications and the improvement of anatomical healing in patients at high risk for mechanical sternal dehiscence after cardiac surgery by mean of median sternotomy. METHODS: A prospective, randomized, study was performed and 310 patients with predisposing factors for sternal dehiscence after sternotomy for cardiac surgery were included...
December 19, 2016: Cardiology and Therapy
https://www.readbyqxmd.com/read/27995127/stereotactic-laser-ablation-for-medically-intractable-epilepsy-the-next-generation-of-minimally-invasive-epilepsy-surgery
#12
REVIEW
Michael J LaRiviere, Robert E Gross
Epilepsy is a common, disabling illness that is refractory to medical treatment in approximately one-third of patients, particularly among those with mesial temporal lobe epilepsy. While standard open mesial temporal resection is effective, achieving seizure freedom in most patients, efforts to develop safer, minimally invasive techniques have been underway for over half a century. Stereotactic ablative techniques, in particular, radiofrequency (RF) ablation, were first developed in the 1960s, with refinements in the 1990s with the advent of modern computed tomography and magnetic resonance-based imaging...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27986874/second-monotherapy-in-childhood-absence-epilepsy
#13
Avital Cnaan, Shlomo Shinnar, Ravindra Arya, Peter C Adamson, Peggy O Clark, Dennis Dlugos, Deborah G Hirtz, David Masur, Tracy A Glauser
OBJECTIVE: To determine optimal second monotherapy for children with childhood absence epilepsy (CAE) experiencing initial treatment failure. METHODS: Children with CAE experiencing treatment failure during the double-blind phase of a randomized controlled trial comparing ethosuximide, valproic acid, and lamotrigine were randomized to open-label second monotherapy with one of the 2 other study therapies. Primary study outcome was freedom from failure proportion at week 16-20 and month 12 visits after randomization...
December 16, 2016: Neurology
https://www.readbyqxmd.com/read/27986482/high-dose-rate-brachytherapy-for-the-treatment-of-lower-extremity-in-stent-restenosis
#14
Karen J Ho, Phillip M Devlin, Arin L Madenci, Marcus E Semel, Edwin C Gravereaux, Louis L Nguyen, Michael Belkin, Matthew T Menard
OBJECTIVE: Historically, edge stenosis and late thrombosis limited the effectiveness of adjunctive endovascular brachytherapy (EVBT) for in-stent restenosis (ISR) after percutaneous transluminal angioplasty (PTA) and stenting. We evaluated an updated protocol of PTA and EVBT for ISR among patients with lower extremity occlusive disease. METHODS: This is a retrospective, single-center review of patients treated with PTA and EVBT for ISR in the iliac and femoropopliteal segments between 2004 and 2012...
December 13, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27959910/assessment-and-accessibility-of-phenotypic-and-genotypic-diversity-of-carrot-daucus-carota-l-var-sativus-cultivars-commercially-available-in-the-united-states
#15
Claire H Luby, Julie C Dawson, Irwin L Goldman
Increased use of intellectual property rights over plant germplasm has led to a complicated landscape for exchange among plant breeders. Our goal was to examine phenotypic and genotypic diversity present in commercially available carrot (Daucus carota L. var. sativus) germplasm in relation to the freedom to operate-the ability for plant breeders to access and use crop genetic diversity. A collection of 140 commercially available carrot cultivars were grown in replicated field trials in the Madison, WI area in 2013 and 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27956248/individualized-cryoballoon-energy-pulmonary-vein-isolation-guided-by-real-time-pulmonary-vein-recordings-the-randomized-ice-t-trial
#16
K R Julian Chun, Marie Stich, Alexander Fürnkranz, Stefano Bordignon, Laura Perrotta, Daniela Dugo, Fabrizio Bologna, Boris Schmidt
BACKGROUND: The ideal energy dosing remains unclear in second-generation cryoballoon (CB) pulmonary vein isolation (PVI). We aimed to investigate the effect of an individualized dosing strategy based on time to PVI (TTI). OBJECTIVE: The purpose of this study was to prospectively investigate the safety and efficacy of individualized PVI using the second-generation CB guided by real-time pulmonary vein recordings. METHODS: Two groups were prospectively randomized: ICE-T group: if TTI <75 seconds, then no bonus freeze; and control group: acute PVI followed by 1 empiric bonus freeze...
December 9, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27943348/the-design-of-the-understanding-outcomes-with-the-s-icd-in-primary-prevention-patients-with-low-ef-study-untouched
#17
Michael R Gold, Reinoud Knops, Martin C Burke, Pier D Lambiase, Andrea M Russo, Maria Grazia Bongiorni, Jean-Claude Deharo, Johan Aasbo, Mikhael F El Chami, Michael Husby, Nathan Carter, Lucas Boersma
AIMS: The UNTOUCHED study will assess the safety and efficacy of the subcutaneous implantable cardioverter defibrillator (S-ICD) in the most common cohort of patients receiving ICDs. The primary goal is to evaluate the inappropriate shock (IAS) free rate in primary prevention patients with a reduced ejection fraction and compare with a historical control of transvenous ICD patients with similar programming. METHODS AND RESULTS: The UNTOUCHED Study is a global, multi-center, prospective, non-randomized study of patients undergoing denovo S-ICD implantation for primary prevention of sudden cardiac death with a left ventricular ejection fraction ≤ 35%...
December 10, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27938678/inter-laboratory-study-to-characterize-the-detection-of-serum-antibodies-against-porcine-epidemic-diarrhoea-virus
#18
Bertel Strandbygaard, Antonio Lavazza, Davide Lelli, Yannick Blanchard, Béatrice Grasland, Sophie Le Poder, Nicolas Rose, Falko Steinbach, Wim H M van der Poel, Frederik Widén, Graham J Belsham, Anette Bøtner
Porcine epidemic diarrhea virus (PEDV) has caused extensive economic losses to pig producers in many countries. It was recently introduced, for the first time, into North America and outbreaks have occurred again in multiple countries within Europe as well. To assess the properties of various diagnostic assays for the detection of PEDV infection, multiple panels of porcine sera have been shared and tested for the presence of antibodies against PEDV in an inter-laboratory ring trial. Different laboratories have used a variety of "in house" ELISAs and also one commercial assay...
December 25, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27926827/decoding-hand-gestures-from-primary-somatosensory-cortex-using-high-density-ecog
#19
Mariana P Branco, Zachary V Freudenburg, Erik J Aarnoutse, Martin G Bleichner, Mariska J Vansteensel, Nick F Ramsey
Electrocorticography (ECoG) based Brain-Computer Interfaces (BCIs) have been proposed as a way to restore and replace motor function or communication in severely paralyzed people. To date, most motor-based BCIs have either focused on the sensorimotor cortex as a whole or on the primary motor cortex (M1) as a source of signals for this purpose. Still, target areas for BCI are not confined to M1, and more brain regions may provide suitable BCI control signals. A logical candidate is the primary somatosensory cortex (S1), which not only shares similar somatotopic organization to M1, but also has been suggested to have a role beyond sensory feedback during movement execution...
December 5, 2016: NeuroImage
https://www.readbyqxmd.com/read/27924754/relevance-of-randomised-controlled-trials-in-oncology
#20
REVIEW
Ian F Tannock, Eitan Amir, Christopher M Booth, Saroj Niraula, Alberto Ocana, Bostjan Seruga, Arnoud J Templeton, Francisco Vera-Badillo
Well-designed randomised controlled trials (RCTs) can prevent bias in the comparison of treatments and provide a sound basis for changes in clinical practice. However, the design and reporting of many RCTs can render their results of little relevance to clinical practice. In this Personal View, we discuss the limitations of RCT data and suggest some ways to improve the clinical relevance of RCTs in the everyday management of patients with cancer. RCTs should ask questions of clinical rather than commercial interest, avoid non-validated surrogate endpoints in registration trials, and have entry criteria that allow inclusion of all patients who are fit to receive treatment...
December 2016: Lancet Oncology
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