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https://www.readbyqxmd.com/read/28103511/neuroglobin-functions-as-a-prognostic-marker-and-promotes-the-tumor-growth-of-glioma-via-suppressing-apoptosis
#1
Bei Zhang, Mingze Chang, Juanhong Wang, Yong Liu
Neuroglobin (Ngb) has been reported to be upregulated by hypoxia and plays an anti-apoptotic function. Previous studies have reported that Ngb is expressed in human glioblastoma cells and up-regulated in hypoxic microregions of glioblastoma tumor xenografts. While, the clinical significance of Ngb and its function in human glioma keep unknown. Ngb expression was analyzed in 86 glioma tissues and 20 normal brain tissues. Results showed that Ngb was significantly overexpressed in glioma tissues compared to normal brain tissues...
January 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28102739/perceptions-of-mild-traumatic-brain-injury-in-adults-a-scoping-review
#2
Katie Mah, Andrea Hickling, Nick Reed
PURPOSE: The purpose of this article is to synthesise the scholarly literature related to perceptions of mild traumatic brain injury (mTBI) and health outcomes in an adult population. METHODS: A scoping review was undertaken. An electronic search of seven databases was conducted. Studies were included if (1) they related to perceptions of mild traumatic brain injury, (2) the population was adults with mild traumatic brain injury, and (3) health outcomes were reported...
January 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28102525/environmental-chemicals-and-aging
#3
REVIEW
Brandon L Pearson, Dan Ehninger
PURPOSE OF REVIEW: Innovations in agriculture and medicine as well as industrial and domestic technologies are essential for the growing and aging global population. These advances generally require the use of novel natural or synthetic chemical agents with the potential to affect human health. Here, we attempt to highlight environmental chemicals and select drugs with the potential to exacerbate aging by directly affecting molecular aging cascades focusing particular attention on the brain...
January 19, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28102207/drosophila-fit-is-a-protein-specific-satiety-hormone-essential-for-feeding-control
#4
Jinghan Sun, Chang Liu, Xiaobing Bai, Xiaoting Li, Jingyun Li, Zhiping Zhang, Yunpeng Zhang, Jing Guo, Yan Li
Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms for controlling protein feeding remain poorly understood. Here we report that in Drosophila, protein intake-induced feeding inhibition (PIFI) is specific to protein-containing food, and this effect is mediated by a fat body (FB) peptide named female-specific independent of transformer (FIT). Upon consumption of protein food, FIT expression is greatly elevated. Secreted FIT peptide in the fly haemolymph conveys this metabolic message to the brain, thereby promoting the release of Drosophila insulin-like peptide 2 (DILP2) and suppressing further protein intake...
January 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28102097/familiar-auditory-sensory-training-in-chronic-traumatic-brain-injury-a-case-study
#5
Emily Galassi Sullivan, Ann Guernon, Brett Blabas, Amy A Herrold, Theresa L-B Pape
PURPOSE: The evaluation and treatment for patients with prolonged periods of seriously impaired consciousness following traumatic brain injury (TBI), such as a vegetative or minimally conscious state, poses considerable challenges, particularly in the chronic phases of recovery. METHOD: This blinded crossover study explored the effects of familiar auditory sensory training (FAST) compared with a sham stimulation in a patient seven years post severe TBI. Baseline data were collected over 4 weeks to account for variability in status with neurobehavioral measures, including the Disorders of Consciousness scale (DOCS), Coma Near Coma scale (CNC), and Consciousness Screening Algorithm...
January 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28102028/the-involvement-of-msmk-in-pathogenesis-of-the-streptococcus-suis-serotype-2
#6
Mei-Fang Tan, Wan-Quan Liu, Chun-Yan Zhang, Ting Gao, Lin-Lin Zheng, De-Xin Qiu, Lu Li, Rui Zhou
Streptococcus suis serotype 2 (SS2) is an important swine and human pathogen that causes global economic and public health problems. Virulent S. suis strains successfully maintain high bacterial concentrations in host blood and rapidly adapt to challenging environments within hosts. Successful survival in hosts is a major factor influencing the pathogenesis of SS2. We have previously identified that SS2 colonization in mouse brain is possibly affected by the ATPase, MsmK of carbohydrate ATP-binding cassette (ABC) transporters because of carbohydrate utilization...
January 19, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28101838/renal-consequences-of-preterm-birth
#7
REVIEW
Amelie Stritzke, Sumesh Thomas, Harish Amin, Christoph Fusch, Abhay Lodha
BACKGROUND: The developmental origin of health and disease concept identifies the brain, cardiovascular, liver, and kidney systems as targets of fetal adverse programming with adult consequences. As the limits of viability in premature infants have been pushed to lower gestational ages, the long-term impact of prematurity on kidneys still remains a significant burden during hospital stay and beyond. OBJECTIVES: The purpose of this study is to summarize available evidence, mechanisms, and short- and long-term renal consequences of prematurity and identify nephroprotective strategies and areas of uncertainty...
December 2017: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/28101762/neuropsychological-assessment-in-migraine-patients-a-descriptive-review-on-cognitive-implications
#8
REVIEW
Maria Foti, Viviana Lo Buono, Francesco Corallo, Rosanna Palmeri, Placido Bramanti, Silvia Marino
Migraine is considered a disabling disorder with highly prevalence in population. Recent studies report that migraine patients have a cognitive decline associated to structural brain alterations. We search on PubMed and Web of Science databases and screening references of included studies and review articles for additional citations. From 519 studies identified, only 16 met the inclusion criteria. All studies were conducted on 1479 migraineurs (190 non-migraine headache and 11,978 controls subject) and examined the association between migraine and cognitive impairment...
January 18, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28098514/edible-and-medicinal-mushrooms-emerging-brain-food-for-the-mitigation-of-neurodegenerative-diseases
#9
Chia-Wei Phan, Pamela David, Vikineswary Sabaratnam
There is an exponential increase in dementia in old age at a global level because of increasing life expectancy. The prevalence of neurodegenerative diseases such as dementia and Alzheimer's disease (AD) will continue to rise steadily, and is expected to reach 42 million cases worldwide in 2020. Despite the advancement of medication, the management of these diseases remains largely ineffective. Therefore, it is vital to explore novel nature-based nutraceuticals to mitigate AD and other age-related neurodegenerative disorders...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28096541/the-mucosal-immune-system-master-regulator-of-bidirectional-gut-brain-communications
#10
REVIEW
Nick Powell, Marjorie M Walker, Nicholas J Talley
Communication between the brain and gut is not one-way, but a bidirectional highway whereby reciprocal signals between the two organ systems are exchanged to coordinate function. The messengers of this complex dialogue include neural, metabolic, endocrine and immune mediators responsive to diverse environmental cues, including nutrients and components of the intestinal microbiota (microbiota-gut-brain axis). We are now starting to understand how perturbation of these systems affects transition between health and disease...
January 18, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28096132/innovative-techniques-for-evaluating-behavioral-nutrition-interventions
#11
REVIEW
Rachel E Scherr, Kevin D Laugero, Dan J Graham, Brian T Cunningham, Lisa Jahns, Karina R Lora, Marla Reicks, Amy R Mobley
Assessing outcomes and the impact from behavioral nutrition interventions has remained challenging because of the lack of methods available beyond traditional nutrition assessment tools and techniques. With the current high global obesity and related chronic disease rates, novel methods to evaluate the impact of behavioral nutrition-based interventions are much needed. The objective of this narrative review is to describe and review the current status of knowledge as it relates to 4 different innovative methods or tools to assess behavioral nutrition interventions...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28095420/molecular-mechanism-of-disease-associated-mutations-in-the-pre-m1-helix-of-nmda-receptors-and-potential-rescue-pharmacology
#12
Kevin K Ogden, Wenjuan Chen, Sharon A Swanger, Miranda J McDaniel, Linlin Z Fan, Chun Hu, Anel Tankovic, Hirofumi Kusumoto, Gabrielle J Kosobucki, Anthony J Schulien, Zhuocheng Su, Joseph Pecha, Subhrajit Bhattacharya, Slavé Petrovski, Adam E Cohen, Elias Aizenman, Stephen F Traynelis, Hongjie Yuan
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A and GluN2B subunits show the strongest signal for being depleted of missense variants. We find that this includes the GluN2 pre-M1 helix and linker between the agonist-binding domain (ABD) and first transmembrane domain (M1). We then evaluate the functional changes of multiple missense mutations in the NMDAR pre-M1 helix found in children with epilepsy and developmental delay...
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28094974/monitoring-dopamine-responses-to-potassium-ion-and-nomifensine-by-in-vivo-microdialysis-with-online-liquid-chromatography-at-one-minute-resolution
#13
Khanh Thieu Ngo, Erika L Varner, Adrian Charles Michael, Stephen G Weber
Recently, our laboratory has demonstrated the technical feasibility of monitoring dopamine at one-min temporal resolution with microdialysis and online liquid chromatography. Here, we monitor dopamine in the rat striatum during local delivery of potassium ion and nomifensine in awake-behaving rats. Microdialysis probes were implanted and dopamine was monitored one or four Days later under basal conditions, during 10-min applications of 60 mM or 100 mM K+, and during 15-min applications of 10 µM nomifensine: K+ and nomifensine were delivered locally by adding them to the microdialysis perfusion fluid...
January 17, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28094295/loss-of-pafr-prevents-neuroinflammation-and-brain-dysfunction-after-traumatic-brain-injury
#14
Xiang-Jie Yin, Zhen-Yan Chen, Xiao-Na Zhu, Jin-Jia Hu
Traumatic brain injury (TBI) is a principal cause of death and disability worldwide, which is a major public health problem. Death caused by TBI accounts for a third of all damage related illnesses, which 75% TBI occurred in low and middle income countries. With the increasing use of motor vehicles, the incidence of TBI has been at a high level. The abnormal brain functions of TBI patients often show the acute and long-term neurological dysfunction, which mainly associated with the pathological process of malignant brain edema and neuroinflammation in the brain...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093969/traumatic-brain-injury-preclinical-imaging-diagnostic-s-and-therapeutic-approaches
#15
Eric L Kaijzel, Ermond R van Beek, Marieke A Stammes, Ivo Que, Alan B Chan, Clemens W G M Löwik, Luis J Cruz
BACKGROUND: Traumatic brain injury (TBI) is a result of an external physical force to the head that traumatically injures the brain. It is a major public health problem worldwide and mainly results from falls, vehicle accidents and violence. Clinical problem: The management of TBI, causing a wide spectrum of possible health outcomes, has barely changed over the years as encouraging outcomes from many pre-clinical therapeutic and pharmacological studies have only rarely been translated to the clinical situation...
January 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28093508/vertical-sleeve-gastrectomy-reduces-blood-pressure-and-hypothalamic-endoplasmic-reticulum-stress-in-mice
#16
Anne K McGavigan, Zachariah M Henseler, Darline Garibay, Scott D Butler, Sisitha Jayasinghe, Ruth E Ley, Robin L Davisson, Bethany P Cummings
Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes remarkable improvements in cardiometabolic health, including hypertension remission. However, the mechanisms responsible remain undefined and poorly studied. Therefore, we developed and validated the first murine model of VSG that recapitulates the blood pressure lowering effect of VSG using gold-standard radiotelemetry technology. We used this model to investigate several potential mechanisms, including body weight, brain endoplasmic reticulum (ER) stress signaling and brain inflammatory signaling, all critical contributors to obesity-associated hypertension pathogenesis...
January 12, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28093220/increased-oxytocin-levels-among-abstinent-heroin-addicts-association-with-aggressiveness-psychiatric-symptoms-and-perceived-childhood-neglect
#17
Lidia M Gerra, Gilberto Gerra, Laura Mercolini, Matteo Manfredini, Lorenzo Somaini, Chiara M Pieri, Maina Antonioni, Michele Protti, Paolo Ossola, Carlo Marchesi
A disruption of the oxytocin system seems to affect a variety of brain functions including emotions, mood and social behavior possibly underlying severe social deficits and susceptibility for substance use and mental health disorders. Early life adversity, such as insecure attachment in childhood, has been suggested to influence oxytocin tone contributing to a condition of neurobiological vulnerability. Aim of the present study was to investigate oxytocin serum levels in abstinent heroin addicted patients, in comparison with healthy controls, and the possible correlation with co-occurring psychiatric symptoms, aggressiveness and perception of parental neglect...
January 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28092972/tracking-dynamic-interactions-between-structural-and-functional-connectivity-a-tms-eeg-dmri-study
#18
Enrico Amico, Olivier Bodart, Mario Rosanova, Olivia Gosseries, Lizette Heine, Pieter Van Mierlo, Charlotte Martial, Marcello Massimini, Daniele Marinazzo, Steven Laureys
Transcranial magnetic stimulation (TMS) in combination with neuroimaging techniques allows to measure the effects of a direct perturbation of the brain. When coupled to high density electroencephalography (TMS/hd-EEG), TMS pulses revealed electrophysiological signatures of different cortical modules in health and disease. However, the neural underpinnings of these signatures remain unclear. Here, by applying multimodal analyses of cortical response to TMS recordings and diffusion magnetic resonance imaging (dMRI) tractography, we investigated the relationship between functional and structural features of different cortical modules in a cohort of awake healthy volunteers...
January 16, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28092760/serum-brain-derived-neurotrophic-factor-and-stability-of-depressive-symptoms-in-coronary-heart-disease-patients-a-prospective-study
#19
Stella L Kuhlmann, Mira Tschorn, Volker Arolt, Katja Beer, Julia Brandt, Laura Grosse, Wilhelm Haverkamp, Jacqueline Müller-Nordhorn, Nina Rieckmann, Johannes Waltenberger, Katharina Warnke, Rainer Hellweg, Andreas Ströhle
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients. METHODS: At baseline, N=225 CHD patients were enrolled while hospitalized...
December 23, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28092661/interactions-between-the-microbiota-immune-and-nervous-systems-in-health-and-disease
#20
REVIEW
Thomas C Fung, Christine A Olson, Elaine Y Hsiao
The diverse collection of microorganisms that inhabit the gastrointestinal tract, collectively called the gut microbiota, profoundly influences many aspects of host physiology, including nutrient metabolism, resistance to infection and immune system development. Studies investigating the gut-brain axis demonstrate a critical role for the gut microbiota in orchestrating brain development and behavior, and the immune system is emerging as an important regulator of these interactions. Intestinal microbes modulate the maturation and function of tissue-resident immune cells in the CNS...
January 16, 2017: Nature Neuroscience
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