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https://www.readbyqxmd.com/read/29891733/long-term-visual-outcome-and-its-predictors-in-macular-oedema-secondary-to-retinal-vein-occlusion-treated-with-dexamethasone-implant
#1
Catharina Busch, Matus Rehak, Chintan Sarvariya, Dinah Zur, Matias Iglicki, Luiz H Lima, Alessandro Invernizzi, Francesco Viola, Kushal Agrawal, Suthasinee Sinawat, Aude Couturier, Aanchal Mehta, Rakesh Juneja, Hardik Jain, Aniruddha Kishandutt Agarwal, Neha Goel, Manish Nagpal, Vishali Gupta, Alay Banker, Anat Loewenstein, Mali Okada, Ali Osman Saatci, Ahmad M Mansour, Jay Chhablani
BACKGROUND: To evaluate the functional long-term outcome in patients with macular oedema (MO) secondary to central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) treated with dexamethasone implant (DEX implant) and to identify its clinical predictors. METHODS: A 24-month, retrospective, multinational, real-world study. Chart review of patients with either naïve or recurrent MO secondary to CRVO/BRVO treated with DEX implant, including best-corrected visual acuity (BCVA), central subfield thickness (CST), demographic baseline characteristics and details of any additional treatment during follow-up...
June 11, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29858676/subjective-evaluation-of-visual-acuity-is-not-reliable-to-detect-disease-activity-in-different-exudative-maculopathies
#2
Marie-Christine Bruender, Nicola Benjamin, Hansjuergen Thomas Agostini, Andreas Stahl, Christoph Ehlken
BACKGROUND: Patients with exudative maculopathies (neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO)) are faced with a high burden of examinations and treatments. This study was conceived to analyze the accuracy of a subjective evaluation of visual acuity (VA) and metamorphopsia to detect disease reactivation, compared to morphological signs of reactivation assessed by means of SD-OCT. METHODS: Retrospective study of 888 patients treated for nAMD (n = 638), DME (84), BRVO (110), and CRVO (56) was conducted...
June 1, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29850324/sequential-observations-of-conversion-from-nonischemic-to-ischemic-central-retinal-vein-occlusion-using-optical-coherence-tomography-angiography
#3
Akira Fukutomi, Kotaro Tsuboi, Hikari Ono, Yuichiro Ishida, Motohiro Kamei
We report the sequential changes of retinal vessels observed by optical coherence tomography angiography (OCTA) in a case of nonischemic central retinal vein occlusion (CRVO) that converted to ischemic CRVO. An 81-year-old woman visited our Retina Clinic because of visual acuity loss in the left eye. Funduscopic examination showed venous tortuosity and intraretinal hemorrhage in all four quadrants of the fundus. OCT showed macular edema. Fluorescein angiography (FA) and OCTA showed loss of small capillaries...
2018: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29850214/vascular-endothelial-growth-factor-basic-fibroblast-growth-factor-and-pigment-epithelium-derived-factor-expression-in-the-neovascular-iris-in-retinal-diseases
#4
Heng Miao, Xianru Hou, De-Kuang Hwang, Yong Tao
Objective: To determine the expression of cytokines in the iris of patients with neovascular glaucoma (NVG). Methods: Patients with NVG associated with proliferative diabetic retinopathy (PDR, group 1) or central retinal vein occlusion (CRVO, group 2) who had undergone surgical treatment were enrolled. Patients with primary open-angle glaucoma requiring surgical treatment were included in the control group (group 3). All iris specimens were obtained during trabeculectomy, 7 days after intravitreal injections of ranibizumab...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29804112/comparing-cytokine-kinetics-between-ranibizumab-and-aflibercept-in-central-retinal-vein-occlusion-with-macular-edema
#5
Osamu Kotake, Hidetaka Noma, Kanako Yasuda, Ryosuke Motohashi, Hiroshi Goto, Masahiko Shimura
PURPOSE: To investigate dynamic changes in aqueous humor levels of vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and inflammatory factors in patients receiving intravitreal ranibizumab injection (IRI) or intravitreal aflibercept injection (IAI) to treat central retinal vein occlusion (CRVO) with macular edema. METHODS: In 22 CRVO patients scheduled to receive 3 doses of ranibizumab (11 eyes) or aflibercept (11 eyes) at monthly intervals, aqueous samples were collected at the time of intravitreal injection...
May 25, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29785994/the-efficacy-of-intravitreal-dexamethasone-implant-as-the-first-line-treatment-for-retinal-vein-occlusion-related-macular-edema-in-a-real-life-scenario
#6
Mert Simsek, Mehmet Citirik, Serdar Ozates, Dilara Ozkoyuncu
Purpose: This study evaluated the effect of intravitreal dexamethasone implant (IDI; Ozurdex) injection for treating macular edema in patients with branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). Methods: This prospective study included 40 eyes of 40 patients with nonischemic BRVO and 31 eyes of 31 patients with nonischemic CRVO who received IDI injection as the first-line treatment for macular edema. The best-corrected visual acuity (BCVA) value before and after the treatment; intraocular pressure; optic coherence tomography findings; and all ocular examination findings, including central foveal thickness (CFT) measurement and fluorescein angiography findings, were evaluated for each patient...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29705175/ischemic-retinal-vein-occlusion-characterizing-the-more-severe-spectrum-of-retinal-vein-occlusion
#7
REVIEW
Meiaad Khayat, Michael Williams, Noemi Lois
Retinal vein occlusion (RVO), including central (CRVO), branch (BRVO) and hemicentral and hemispheric RVO, is the second most common vascular cause of visual loss, surpassed only by diabetic retinopathy. The presence and extent of retinal ischemia in RVO is associated with a worse prognosis. On this basis, most previously conducted studies considered iRVO and non-iRVO as separate entities based on set thresholds of existing retinal ischemia, as determined by fundus fluorescein angiography (FFA). Other diagnostic technologies have been used specifically in the differentiation of iCRVO and non-iCRVO...
April 26, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29619262/optical-coherence-tomography-angiography-of-combined-central-retinal-artery-and-vein-occlusion
#8
Shuo-Chieh Wu, Victor M Villegas, Jaclyn L Kovach
Optical coherence tomography angiography (OCTA) is a new, noninvasive technology that enables detailed evaluation of flow in the retinal and choroidal vasculature. The authors believe this to be the first report to describe the optical coherence tomography angiography findings associated with combined central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO).
2018: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29600177/intravitreal-anti-vegf-agents-oral-glucocorticoids-and-laser-photocoagulation-combination-therapy-for-macular-edema-secondary-to-retinal-vein-occlusion-preliminary-report
#9
Xiao-Xiao Feng, Cheng Li, Wan-Wen Shao, Yong-Guang Yuan, Xiao-Bing Qian, Qi-Shan Zheng, Yu-Jie Li, Qian-Ying Gao
AIM: To evaluate the efficacy and safety of combined anti-vascular endothelial growth factor (VEGF) agents, oral glucocorticoid, and laser photocoagulation therapy for macular edema (ME) secondary to retinal vein occlusion (RVO). METHODS: This study included 16 eyes of 16 patients with RVO-associated ME. Patients were initially treated with oral prednisone and an intravitreal anti-VEGF agent. Two weeks later, patients underwent standard laser photocoagulation. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), and retinal vessel oxygenation were examined over 12mo...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29572586/elevated-lipocalin-2-level-in-aqueous-humor-of-patients-with-central-retinal-vein-occlusion
#10
Yaran Koban, Seda Sahin, Fatih Boy, Fatih Kara
PURPOSE: To assess the concentrations of lipocalin-2 (LCN2) in the serum and the aqueous humor of patients with central retinal vein occlusion (CRVO). METHODS: The concentrations of LCN2 in the serum and aqueous humor of 16 cataract patients and 16 patients with CRVO with macular edema were compared. Collection of aqueous samples was conducted in the operating theater under sterile conditions and just prior to intravitreal ranibizumab injection or cataract surgery...
March 23, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29566387/spectral-domain-optical-coherence-tomography-driven-treat-and-extend-and-pro-re-nata-regimen-in-patients-with-macular-oedema-due-to-retinal-vein-occlusion-24-month-evaluation-and-outcome-predictors
#11
Maria-Magdalena Guichard, Anton R Xavier, Cengiz Türksever, Christian Pruente, Katja Hatz
PURPOSE: To analyse the efficacy and outcome predictors of ranibizumab using a spectral-domain optical coherence tomography (SD-OCT)-driven treat-and-extend regimen (TER) versus SD-OCT-driven pro re nata regimen (PRN) in patients with cystoid macular oedema (CME) due to branch or central retinal vein occlusion (BRVO, CRVO). METHODS: Retrospective, consecutive case series. Evaluation included best corrected visual acuity (BCVA), morphological parameters on SD-OCT, and treatment frequency...
March 22, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29554389/swept-source-oct-angiographic-imaging-of-a-central-retinal-vein-occlusion-during-pregnancy
#12
Elie Motulsky, Fang Zheng, Guanghui Liu, Giovanni Gregori, Philip J Rosenfeld
To avoid fluorescein angiography in a pregnant woman diagnosed with a central retinal vein occlusion (CRVO), swept-source optical coherence tomography angiography (SS-OCTA) was performed and showed no evidence of decreased central retinal perfusion leading to the diagnosis of a nonischemic CRVO. Five months after an intravitreal injection of steroid, both her vision and the retinal appearance had returned to normal. This case demonstrates how a noninvasive, safe, 12 mm × 12 mm SS-OCTA image of a CRVO is useful in evaluating the retinal perfusion at presentation and follow-up during pregnancy...
March 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29550932/the-short-term-efficacy-of-intravitreal-ranibizumab-aflibercept-and-dexamethasone-implant-in-the-treatment-of-macular-edema-due-to-non-ischemic-central-retinal-vein-occlusion
#13
Ozlem Eski Yucel, Hakki Birinci, Yuksel Sullu
PURPOSE: To assess and compare the efficacy over 6 months of intravitreal ranibizumab (IR), aflibercept (IA) and dexamethasone implant (IDI) in eyes with macular edema (ME) secondary to non-ischemic central retinal vein occlusion (CRVO). METHODS: This is a retrospective single-center study. Patients who received pro re nata treatment of IR 0.5 mg, IA 2 mg or IDI 0.7 mg (as Group 1, Group 2, and Group 3, respectively) for the treatment of ME due to non-ischemic CRVO were included in the study...
March 17, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29511062/neuroretinal-atrophy-following-resolution-of-macular-oedema-in-retinal-vein-occlusion
#14
Dominika Podkowinski, Ana-Maria Philip, Wolf-Dieter Vogl, Jutta Gamper, Hrvoje Bogunovic, Bianca S Gerendas, Bilal Haj Najeeb, Sebastian M Waldstein, Ursula Schmidt-Erfurth
BACKGROUND/AIMS: To characterise neuroretinal atrophy in retinal vein occlusion (RVO). METHODS: We included patients with central/branch RVO (CRVO=196, BRVO=107) who received ranibizumab according to a standardised protocol for 6 months. Retinal atrophy was defined as the presence of an area of retinal thickness (RT) <260 µm outside the foveal centre. Moreover, the thickness of three distinct retinal layer compartments was computed as follows: (1) retinal nerve fibre layer to ganglion cell layer, (2) inner plexiform layer (IPL) to outer nuclear layer (ONL) and (3) inner segment/outer segment junction to retinal pigment epithelium...
March 6, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29505511/cardiovascular-risk-factors-in-patients-with-combined-central-retinal-vein-occlusion-and-cilioretinal-artery-occlusion-case-report
#15
Andrzej Grzybowski, Waldemar Elikowski, Magdalena Gaca-Wysocka
RATIONALE: To analyze cardiovascular risk factors and comorbidity of acute unilateral visual loss due to combined central retinal vein occlusion (CRVO) and cilioretinal artery occlusion (CLRAO). PATIENT CONCERNS: Among patients with retinal vein or artery occlusion hospitalized at the Department of Ophthalmology between January 2011 and August 2017, subjects with combined CRVO/CLRAO were selected. All of them underwent ophthalmologic and cardiologic examination, including fluorescein angiography, optical coherence tomography, 12-lead electrocardiogram, transthoracic and transesophageal echocardiography, carotid Doppler sonography, cerebral magnetic resonance imaging, and a panel of laboratory tests...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29487816/correlation-between-macular-ganglion-cell-inner-plexiform-layer-thickness-and-visual-acuity-after-resolution-of-the-macular-edema-secondary-to-central-retinal-vein-occlusion
#16
Hyun Ju Kim, Han Gyul Yoon, Seong Taeck Kim
AIM: To examine the thickness of the ganglion cell-inner plexiform layer (GCIPL) in eyes with resolved macular edema (ME) in non-ischemic central retinal vein occlusion (CRVO), applying spectral-domain optical coherence tomography (SD-OCT), and its relationship with visual acuity. METHODS: The retrospective observational case-control study included 30 eyes of non-ischemic CRVO patients with resolved ME (ME eyes) after treatment, and 30 eyes of non-ischemic CRVO patients without ME (non-ME eyes)...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29474305/use-of-the-ischemic-index-on-widefield-fluorescein-angiography-to-characterize-a-central-retinal-vein-occlusion-as-ischemic-or-nonischemic
#17
Akshay S Thomas, Mridul K Thomas, Avni P Finn, Sharon Fekrat
PURPOSE: To understand the relationship between baseline ischemic index (IsI) values on ultra-widefield fluorescein angiography and classification as ischemic central retinal vein occlusion (CRVO). METHODS: Single-center retrospective cohort study of CRVO patients imaged using ultra-widefield fluorescein angiography from which IsI values were calculated. An ischemic CRVO was defined as those eyes with an afferent pupillary defect and counting fingers acuity or worse or neovascularization during the first year of follow-up...
February 22, 2018: Retina
https://www.readbyqxmd.com/read/29447089/aflibercept-versus-bevacizumab-and-or-ranibizumab-for-recurrent-macular-edema-secondary-to-central-retinal-vein-occlusion
#18
Cem Ozgonul, Vaidehi S Dedania, Cagri G Besirli
PURPOSE: To compare functional and anatomic outcomes of treatment with intravitreal aflibercept versus bevacizumab and/or ranibizumab in patients with recurrent macular edema (ME) secondary to central retinal vein occlusion (CRVO). METHODS: Retrospective, comparative case series of patients with recurrent ME in the setting of CRVO. Patients with recurrent ME received treatment with aflibercept (Group 1, G1) or bevacizumab and/or ranibizumab (Group 2, G2). Primary outcome measures were best-corrected visual acuity (BCVA) and central foveal thickness (CFT)...
February 15, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29426292/pre-treatment-clinical-features-in-central-retinal-vein-occlusion-that-predict-visual-outcome-following-intravitreal-ranibizumab
#19
Kerr Brogan, Monica Precup, Amanda Rodger, David Young, David Francis Gilmour
BACKGROUND: Predicting how patients with central retinal vein occlusion (CRVO) will respond to intravitreal anti-VEGF is challenging. The purpose of this study was to identify pre-treatment clinical features in CRVO that predict visual acuity (VA) following intravitreal ranibizumab. METHODS: Medical records, fundus images and optical coherence tomography (OCT) scans of treatment naïve patients with CRVO receiving PRN intravitreal ranibizumab were retrospectively reviewed...
February 9, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29403585/effects-of-dexamethasone-implant-on-multifocal-electroretinography-in-central-retinal-vein-occlusion
#20
Muhammed Nurullah Bulut, Ümit Çallı, Güzide Akçay, Ulviye Kıvrak, Kezban Bulut, Yusuf Özertürk
Purpose: To investigate the effect of Ozurdex (dexamethasone intravitreal implant) on multifocal electroretinography (mfERG) findings during the treatment of macular edema secondary to the central retinal vein occlusion (CRVO). Methods: Fifteen eyes of 15 patients who were treated with Ozurdex implant due to CRVO-related macular edema were included in this study. Best corrected visual acuity (BCVA), central macular thickness (CMT), and mfERG evaluations were performed for all patients before injection of Ozurdex...
January 2018: Journal of Ophthalmic & Vision Research
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