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Hasan Basri Arifoglu, Necati Duru, Orhan Altunel, Burhan Baskan, Bedirhan Alabay, Mustafa Atas
PURPOSE: The objective of this study was to evaluate subfoveal choroidal thickness (SFCT) using enhanced depth imaging optical coherence tomography (EDI-OCT) in patients with naïve branch retinal vein occlusion (BRVO) before and after intravitreal dexamethasone implant (Ozurdex®) injection. METHODS: Thirty-nine patients with unilateral BRVO and 35 healthy subjects were included in this prospective study. Choroidal thickness was evaluated by EDI-OCT at baseline and 1 month after dexamethasone implant...
July 2016: Arquivos Brasileiros de Oftalmologia
Yengwoo Son, Seungwoo Lee, Jongyeop Park
PURPOSE: Thinning of the lamina cribrosa thickness (LCT) and prelaminar tissue thickness (PT) has been observed in patients with glaucoma, and branch retinal vein occlusion (BRVO) is reportedly related to glaucoma. To test the hypothesis that thinning of the LCT and PT occurs in patients with BRVO, we investigated possible correlations of the LCT and PT in BRVO-affected eyes and fellow eyes and compared these values with age-, sex-, and underlying disease-matched eyes. METHOD: The study included 50 patients (50 eyes) with unilateral BRVO and 35 control subjects (35 eyes)...
September 14, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Lasse Jørgensen Cehofski, Anders Kruse, Martin Bøgsted, Sigriður Olga Magnusdottir, Allan Stensballe, Bent Honoré, Henrik Vorum
Animal models of experimental branch retinal vein occlusion (BRVO) provide a unique opportunity to study protein changes directly in retinal tissue. Results from these experimental models suggest that experimental BRVO is associated with an upregulation of extracellular matrix remodeling and adhesion signaling processes. To study whether these processes could be blocked by inhibition of VEGF-A, a porcine model of experimental BRVO was combined with proteomic analyses. In six Danish Landrace pigs experimental BRVO was induced with argon laser in both eyes...
September 9, 2016: Experimental Eye Research
Pukhraj Rishi, Neha Raka, Ekta Rishi
BACKGROUND: To study potential ischemic effects of intravitreal Bevacizumab (IVB) on unaffected retina in treatment-naive eyes with macular edema secondary to branch retinal vein occlusion (BRVO) and contralateral eyes secondary to systemic absorption. METHODS AND FINDINGS: Prospective, interventional series included 27 treatment-naive eyes with BRVO and macular edema. EXCLUSION CRITERIA: Eyes with diabetic retinopathy, glaucoma, vasculitides, papilledema or systemic neurologic condition...
2016: PloS One
Orhan Altunel, Altan Göktaş, Necati Duru, Ayşe Özköse, Hasan Basri Arifoğlu, Mustafa Ataş
PURPOSE: To investigate the effect of age on dexamethasone intravitreal implant (Ozurdex®) response in macular edema secondary to branch retinal vein occlusion (BRVO). METHODS: Seventy-three eyes of 73 patients with macular edema secondary to BRVO were recruited in the study. The patients in the study were divided into the following four groups according to their ages: group 1 (<60 years), group 2 (60-69 years), group 3 (70-79 years), and group 4 (≥80 years)...
September 6, 2016: Seminars in Ophthalmology
Teruyo Kida, Josef Flammer, Hidehiro Oku, Seita Morishita, Masanori Fukumoto, Hiroyuki Suzuki, Katarzyna Konieczka, Tsunehiko Ikeda
BACKGROUND: Branch retinal vein occlusion (BRVO) commonly occurs at the arteriovenous crossing in the unilateral eye, and cardiovascular diseases can be risk factors of BRVO. However, the pathomechanism leading to BRVO is not yet clear. In addition to mechanical compression, the vein might locally constrict due to an altered biochemical environment, such as an increase in the concentration of endothelin-1 (ET-1). We evaluated changes in ET-1 following injection of intravitreal bevacizumab (IVB), which is the anti-vascular endothelial growth factor (VEGF) agent with the longest serum half-life, to determine the effect on BRVO-related macular edema...
2016: EPMA Journal
Su-Ho Lim, Mirae Kim, Woohyok Chang, Min Sagong
PURPOSE: To compare the lamina cribrosa (LC) thickness of healthy subjects and patients with unilateral branch retinal vein occlusion (BRVO), and to determine possible correlations between the LC thickness and the BRVO subtypes. METHODS: This prospective, cross-sectional study included a total of 46 patients with naive, untreated, unilateral BRVO and 31 healthy control subjects. The occlusion site was divided into two BRVO types: arteriovenous crossing BRVO (AV-BRVO) and optic nerve BRVO (ON-BRVO)...
July 12, 2016: Retina
Karen M Wai, Mehnaz Khan, Sunil Srivastava, Aleksandra Rachitskaya, Fabiana Q Silva, Ryan Deasy, Andrew P Schachat, Amy Babiuch, Justis P Ehlers, Peter K Kaiser, Alex Yuan, Rishi P Singh
AIM: To determine the impact of initial visual acuity (VA) on anti-vascular endothelial growth factor (VEGF) treatment outcomes in patients with macular oedema secondary to retinal vein occlusions in routine clinical practice. METHODS: A retrospective study was conducted at a single academic institution to identify 177 treatment naïve patients with macular oedema secondary to branch retinal vein occlusion (BRVO), hemiretinal vein occlusion (HRVO) and central retinal vein occlusion (CRVO) treated with intravitreal anti-VEGFs...
August 8, 2016: British Journal of Ophthalmology
Yuya Terubayashi, Teruyo Kida, Masanori Fukumoto, Jun Sugasawa, Seita Morishita, Hiroyuki Suzuki, Tsunehiko Ikeda
PURPOSE: Retinal arterial macroaneurysm (RAM) has been reported in association with branch retinal vein occlusion (BRVO), and usually BRVO precedes RAM. We present a long-term follow-up case report of unilateral multiple RAMs that developed BRVO following ruptured RAM in the same retinal quadrant. CASE PRESENTATION: An 80-year-old woman presented with floaters in her right eye in June 2012. Visual acuity (VA) was 20/25 in her right eye with posterior capsular opacity...
January 2016: Case Reports in Ophthalmology
Nicole Eter, Andreas Mohr, Joachim Wachtlin, Nicolas Feltgen, Andrew Shirlaw, Richard Leaback
PURPOSE: To evaluate the relationship between duration of macular edema associated with retinal vein occlusion (RVO) and the achievement of vision gain in patients receiving dexamethasone intravitreal implant (DEX implant) in real-world clinical practice, and to define patterns of use of DEX implant and its efficacy and safety in the treatment of patients with RVO in clinical practice. METHODS: This prospective, open-label, multicenter, 6-month observational phase IV study conducted at 70 sites in Germany enrolled patients diagnosed with macular edema following branch or central RVO (BRVO, CRVO) who were given DEX implant...
July 26, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Mehreen Adhi, Marco A Bonini Filho, Ricardo N Louzada, Laura Kuehlewein, Talisa E de Carlo, Caroline R Baumal, Andre J Witkin, Srinivas R Sadda, David Sarraf, Elias Reichel, Jay S Duker, Nadia K Waheed
PURPOSE: To evaluate the perifoveolar retinal capillary network at different depths and to quantify the foveal avascular zone (FAZ) in eyes with retinal vein occlusion (RVO) compared with their fellow eyes and healthy controls using spectral-domain optical coherence tomography angiography (SD-OCTA). METHODS: We prospectively recruited 23 patients with RVO including 15 eyes with central RVO (CRVO) and 8 eyes with branch RVO (BRVO), their fellow eyes, and 8 age-matched healthy controls (8 eyes) for imaging on prototype OCTA software within RTVue-XR Avanti...
July 1, 2016: Investigative Ophthalmology & Visual Science
Yijun Hu, Alp Atik, Honghua Yu, Tao Li, Boyong Zhang, Dongli Li, Ning Cai, Yang Yu, Jing Chen, Guodong Li, Ling Yuan
PURPOSE: To investigate the serum heparanase concentration and heparanase activity of the patients with central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO). METHODS: This prospective study included 23 CRVO patients, 13 BRVO patients and 28 control subjects. Serum heparanase concentration was measured by ELISA. Serum heparanase activity was determined using a heparan degrading enzyme assay kit (Mountain View, CA, USA). Multivariate logistic regression was used to adjust for the possible confounding factors when comparing the difference in serum heparanase concentration and activity between patients with RVO and control subjects...
July 15, 2016: Acta Ophthalmologica
Sandra Rezar-Dreindl, Katharina Eibenberger, Andreas Pollreisz, Wolf Bühl, Michael Georgopoulos, Christoph Krall, Roman Dunavölgyi, Günther Weigert, Maria-Elisabeth Kroh, Ursula Schmidt-Erfurth, Stefan Sacu
PURPOSE: To investigate the influence of intravitreal dexamethasone implant on inflammatory and angiogenic cytokine levels in the aqueous of patients with retinal vein occlusion (RVO). METHODS: Forty eyes of 40 consecutive patients with macular oedema (ME) due to branch and central retinal vein occlusion (BRVO/CRVO) were treated with an intravitreal dexamethasone implant (Ozurdex(®) ) at baseline and evaluated until month 6. Retreatment was performed in case of recurrent ME earliest 4 months after the baseline treatment...
July 15, 2016: Acta Ophthalmologica
Shanshan Yu, Jing Lu, Di Cao, Ruyuan Liu, Bingqian Liu, Tao Li, Yan Luo, Lin Lu
BACKGROUND: To evaluate the role of optical coherence tomography angiography (OCTA) in observation of fundus vascular abnormalities. METHODS: Patients (n = 50, 10 in each group) with fundus disorders including branch retinal vein occlusion (BRVO), non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), exudative age-related macular degeneration (AMD), and polypoidal choroidal vasculopathy (PCV) were examined. They underwent imaging of OCTA and fluorescein angiography/indocyanine green angiography...
2016: BMC Ophthalmology
Taneto Tomiyasu, Yoshio Hirano, Munenori Yoshida, Norihiro Suzuki, Takeshi Nishiyama, Akiyoshi Uemura, Tsutomu Yasukawa, Yuichiro Ogura
Intravitreal anti-vascular endothelial growth factor (VEGF) agents can treat macular edema (ME) in branch retinal vein occlusion (BRVO). However, refractory ME, the mechanism of which is not well elucidated, occurs frequently. Sixty-six eyes with ME secondary to BRVO were enrolled in this retrospective observational case-control study. Twenty eyes received a sub-Tenon's capsule injection of triamcinolone acetonide (STTA), 22 eyes an intravitreal anti-VEGF injection (ranibizumab), 16 eyes were switched from STTA to ranibizumab, 4 eyes underwent vitrectomy, and 4 eyes were untreated...
2016: Scientific Reports
Yoshihito Sakanishi, Ami Lee, Ayumi Usui-Ouchi, Rei Ito, Nobuyuki Ebihara
PURPOSE: The purpose of this study was to determine the clinical efficacy of low-frequency intravitreal ranibizumab to treat macular edema due to retinal vein occlusion (RVO). PATIENTS AND METHODS: This was a retrospective examination of cases that received intravitreal ranibizumab for untreated RVO over a period of 12 months. Instead of the conventional three monthly injections, injections were given once during the introductory period. If the recurrence of macular edema was diagnosed during the monthly visit, additional injections were given as needed...
2016: Clinical Ophthalmology
Kaveh Abri Aghdam, Lukas Reznicek, Mostafa Soltan Sanjari, Carsten Framme, Anna Bajor, Annemarie Klingenstein, Marcus Kernt, Florian Seidensticker
AIM: To evaluate the association between the size of peripheral retinal non-perfusion and the number of intravitreal ranibizumab injections in patients with treatment-naive branch retinal vein occlusion (BRVO) and macular edema. METHODS: A total of 53 patients with treatment-naive BRVO and macular edema were included. Each patient underwent a full ophthalmologic examination including optical coherence tomography (OCT) imaging and ultra wide-field fluorescein angiography (UWFA)...
2016: International Journal of Ophthalmology
Yuki Muraoka, Akihito Uji, Akitaka Tsujikawa, Tomoaki Murakami, Sotaro Ooto, Kiyoshi Suzuma, Ayako Takahashi, Yuto Iida, Yuko Miwa, Masayuki Hata, Nagahisa Yoshimura
This prospective study included 63 eyes with acute branch retinal vein occlusion (BRVO) to evaluate the retinal hemorrhagic patterns at the posterior poles and explore their clinical relevance in macular perfusion differentiation. Retinal hemorrhagic patterns and macular perfusion status were evaluated via fundus photography and fluorescein angiography, respectively. Macular perfusion was judged as nonischemic in 30, ischemic in 28, and undeterminable in 5 among the 63 eyes. Predominant hemorrhagic patterns were flame-shaped in 39 (67...
2016: Scientific Reports
Esra Turkseven Kumral, Nursal Melda Yenerel, Nimet Yesim Ercalik, Serhat Imamoglu, Ece Turan Vural
PURPOSE: To evaluate the mean platelet volume (MPV) and the neutrophil/lymphocyte ratio (NLR) in patients with branch retinal vein occlusion (BRVO). METHODS: Thirty patients with branch retinal vein occlusion (BRVO group) and 27 age and sex matched subjects (control group) were included in the study. MPV and NLR parameters obtained from peripheral blood were recorded. RESULTS: The mean age was 62.6 ± 12.3 years in BRVO and 63.5 ± 8...
April 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Jong Chan Im, Jae Pil Shin, In Taek Kim, Dong Ho Park
PURPOSE: The aim of this study was to evaluate the effect of intravitreal dexamethasone implant fragmentation on clinical outcomes in branch retinal vein occlusion (BRVO)-induced macular edema (ME). METHODS: All consecutive patients receiving an intravitreal dexamethasone implant for BRVO-induced ME were divided into two groups depending on whether the implant was intact or had fragmented into two or more pieces on postoperative day 1. Best-corrected visual acuity (BCVA), intraocular pressure (IOP), and central subfield thickness (CST) on spectral-domain optical coherence tomography were measured for 6 months...
2016: Ophthalmologica. Journal International D'ophtalmologie
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