keyword
https://read.qxmd.com/read/38509580/neuroimaging-studies-of-cannabidiol-and-potential-neurobiological-mechanisms-relevant-for-alcohol-use-disorders-a-systematic-review
#1
REVIEW
Tristan Hurzeler, Joshua Watt, Warren Logge, Ellen Towers, Anastasia Suraev, Nicholas Lintzeris, Paul Haber, Kirsten C Morley
The underlying neurobiological mechanisms of cannabidiol's (CBD) management of alcohol use disorder (AUD) remains elusive.Aim We conducted a systematic review of neuroimaging literature investigating the effects of CBD on the brain in healthy participants. We then theorise the potential neurobiological mechanisms by which CBD may ameliorate various symptoms of AUD.Methods This review was conducted according to the PRISMA guidelines. Terms relating to CBD and neuroimaging were used to search original clinical research published in peer-reviewed journals...
March 21, 2024: Journal of cannabis research
https://read.qxmd.com/read/38176941/the-role-of-the-cerebellum-in-drug-reward-a-review
#2
REVIEW
Yong-Bo Wang, Yan Lan
Drug abuse remains a global problem; nonetheless, its mechanism has not yet been fully understood. Recent studies have reported on the non-motor functions of the cerebellum, and evidence from neuroimaging and behavioral studies has suggested the role of cerebellum in drug reward, which has received increasing attention. Furthermore, emerging technological developments have aided in clarifying the various circuits and functions of the cerebellum. Exploring the role of the cerebellum in drug reward can improve our understanding of the mechanism underlying addiction and facilitate the development of new treatment schemes...
October 23, 2023: Journal of Integrative Neuroscience
https://read.qxmd.com/read/37753566/analysis-of-the-brain-transcriptome-for-substance-associated-genes-an-update-on-large-scale-genome-wide-association-studies
#3
JOURNAL ARTICLE
Yihong Zhao, Xuewei Han, Zhi-Liang Zheng
Substance use disorder (SUD) arises from the initiation to subsequent regular, irregular and harmful use of substances such as alcohol, tobacco/nicotine and cannabis. While thousands of genetic variants have been identified from recent large-scale genome-wide association studies (GWAS), understanding their functions in substance involvement and investigating the mechanisms by which they act in the addiction circuits remains challenging. In this study, we re-analysed the brain regional transcriptome data from the most comprehensive postmortem transcriptomic study, with a focus on up- or down-regulation of substance-associated protein-coding genes in the addiction circuit-related brain regions (AddictRegions), including six cortical and 11 subcortical regions...
October 2023: Addiction Biology
https://read.qxmd.com/read/37706104/peroral-exposure-to-cannabis-sativa-ethanol-extract-caused-neuronal-degeneration-and-astrogliosis-in-wistar-rats-prefrontal-cortex
#4
JOURNAL ARTICLE
Olatunji Sunday Yinka, Ogunnaike Philip Olubunmi, Abijo Ayodeji Zabdiel, Owolabi Joshua Oladele, Adelodun Stephen Taiye, Adeoye Ayodele, Fasesan Oluwatoyin Adetutu, Olanrewaju John Afees, Adegbite Ademola Kayode
BACKGROUND: Despite widespread concerns about its possible side effects, notably on the prefrontal cortex (PFC), which mediates cognitive processes, the use of Cannabis sativa as a medicinal and recreational drug is expanding exponentially. This study evaluated possible behavioral alterations, neurotransmitter levels, histological, and immunohistochemical changes in the PFC of Wistar rats exposed to Cannabis sativa . PURPOSE: To evaluate the effect of graded doses of Cannabis sativa on the PFC using behavioural, histological, and immunohistochemical approaches...
April 2023: Annals of Neurosciences
https://read.qxmd.com/read/37433966/fetal-cannabidiol-cbd-exposure-alters-thermal-pain-sensitivity-problem-solving-and-prefrontal-cortex-excitability
#5
JOURNAL ARTICLE
Karli S Swenson, Luis E Gomez Wulschner, Victoria M Hoelscher, Lillian Folts, Kamryn M Korth, Won Chan Oh, Emily Anne Bates
Thousands of people suffer from nausea with pregnancy each year. Nausea can be alleviated with cannabidiol (CBD), a primary component of cannabis that is widely available. However, it is unknown how fetal CBD exposure affects embryonic development and postnatal outcomes. CBD binds and activates receptors that are expressed in the fetal brain and are important for brain development, including serotonin receptors (5HT1A ), voltage-gated potassium (Kv)7 receptors, and the transient potential vanilloid 1 receptor (TRPV1)...
July 11, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37010725/therapeutic-role-of-hemp-cannabis-sativa-against-copper-induced-toxicity-in-labeo-rohita-and-cirrhinus-mrigala
#6
JOURNAL ARTICLE
Azam Jan Afridi, Amina Zuberi, Ali Muhammad Yousafzai, Muhammad Kamran
For decades hemp has been used as a therapeutic agent for enhancing immunity in animals. Current study was conceptualized to find out the protective role of dietary hemp seed products (hemp seed oil (HO) and hemp seed (HS)) against copper-induced toxicity in fish. Fingerlings of Labeo rohita (Rohu) and Cirrhinus mrigala (Mrigal) were exposed to copper at 20% of the 96 h LC50 (1.34 and 1.52 ppm, respectively) for 30 days. Following Cu exposure, fish were maintained on two types of hemp (Cannabis sativa)-supplemented feeds, on graded levels of hemp seed oil (HO: 1%, 2%, 3%) and hemp seed (HS: 5%, 10%, 15%) for 50 days, while one group was the control (without any copper exposure as well as any supplementation)...
April 3, 2023: Biological Trace Element Research
https://read.qxmd.com/read/36994633/peripheral-signature-of-altered-synaptic-integrity-in-young-onset-cannabis-use-disorder-a-proteomic-study-of-circulating-extracellular-vesicles
#7
JOURNAL ARTICLE
Suhas Ganesh, TuKiet T Lam, Rolando Garcia-Milian, Deepak D'Souza, Angus C Nairn, Katya Elgert, Erez Eitan, Mohini Ranganathan
BACKGROUND: Rates of Cannabis Use Disorder (CUD) are highest amongst young adults. Paucity of brain tissues samples limits the ability to examine the molecular basis of cannabis related neuropathology. Proteomic studies of neuron-derived extracellular vesicles (NDEs) isolated from the biofluids may reveal markers of neuropathology in CUD. METHODS: NDEs were extracted using ExoSORT, an immunoaffinity method to enrich NDEs from plasma samples from patients with young onset CUD and matched controls...
March 30, 2023: World Journal of Biological Psychiatry
https://read.qxmd.com/read/36483135/alterations-in-rat-prefrontal-cortex-kynurenic-acid-levels-are-involved-in-the-enduring-cognitive-dysfunctions-induced-by-tetrahydrocannabinol-exposure-during-the-adolescence
#8
JOURNAL ARTICLE
Sarah Beggiato, Alessandro Ieraci, Mariachiara Zuccarini, Patrizia Di Iorio, Robert Schwarcz, Luca Ferraro
INTRODUCTION: Cannabis abuse during adolescence is a risk factor for cognitive impairments in psychiatric disorders later in life. To date, the possible causal relationship between cannabinoids, kynurenic acid (KYNA; i.e., a neuroactive metabolite of tryptophan degradation) and cognition has not been investigated in adolescence. Early exposure to delta 9-tetrahydrocannabinol (THC; i.e., the main psychotropic component of cannabis) causes enduring cognitive deficits, which critically involve impaired glutamatergic function in the prefrontal cortex (PFC)...
2022: Frontiers in Psychiatry
https://read.qxmd.com/read/36419922/regulation-of-glutamate-homeostasis-in-the-nucleus-accumbens-by-astrocytic-cb1-receptors-and-its-role-in-cocaine-motivated-behaviors
#9
JOURNAL ARTICLE
Lan-Yuan Zhang, Andrew Y Kim, Joseph F Cheer
Cannabinoid type 1 receptors (CB1Rs) orchestrate brain reward circuitry and are prevalent neurobiological targets for endocannabinoids and cannabis in the mammalian brain. Decades of histological and electrophysiological studies have established CB1R as presynaptic G-protein coupled receptors (GPCRs) that inhibit neurotransmitter release through retrograde signaling mechanisms. Recent seminal work demonstrates CB1R expression on astrocytes and the pivotal function of glial cells in endocannabinoid-mediated modulation of neuron-astrocyte signaling...
September 2022: Addict Neurosci
https://read.qxmd.com/read/36318403/the-relationship-between-cannabis-cognition-and-schizophrenia-it-s-complicated
#10
JOURNAL ARTICLE
Hakan Kayir, Jessica Ruffolo, Patrick McCunn, Jibran Y Khokhar
The consequences of cannabis use, especially in the context of schizophrenia, have gained increased importance with the legalization of cannabis in North America and across the globe. Cannabis use has multifaceted impacts on cognition in schizophrenia patients and healthy subjects. Healthy subjects, particularly those who initiated cannabis use at earlier ages and used high-potency cannabis for longer durations, exhibited poorer cognition mainly in working memory and attention. Cannabis use in schizophrenia has been associated with symptom exacerbation, longer and more frequent psychotic episodes, and poorer treatment outcomes...
November 2, 2022: Current Topics in Behavioral Neurosciences
https://read.qxmd.com/read/36204167/a-cannabinoid-hypothesis-of-schizophrenia-pathways-to-psychosis
#11
REVIEW
Rachel Little, Dale D'Mello
Background: Observations regarding psychostimulant and psychedelic drug-induced psychotic states led to the dopamine, serotonin, and glutamate hypotheses of schizophrenia. Expanding knowledge about the endocannabinoid system and the impact of exogenous cannabinoids on the brain and behavior have elucidated several putative pathways to cannabis-induced psychosis. Objective: The purpose of the present article was to describe these pathways and propose a cannabinoid hypothesis of schizophrenia...
July 2022: Innovations in Clinical Neuroscience
https://read.qxmd.com/read/36179898/investigation-on-the-neuroprotective-effect-of-a-cannabidiol-enriched-non-psychotropic-cannabis-sativa-l-extract-in-an-in-vitro-model-of-excitotoxicity
#12
JOURNAL ARTICLE
Vittoria Borgonetti, Marco Biagi, Nicoletta Galeotti, Fabrizio Manetti, Paolo Governa
The purpose of this study was to evaluate the neuroprotective effect of a cannabidiol-enriched non-psychotropic Cannabis sativa L. extract (CSE) and its main constituents, cannabidiol and β-caryophyllene. An in vitro model of glutamate-induced neuronal excitotoxicity using SH-SY5Y cells was optimized. The impact of CSE on glutamate-impaired cell viability, brain-derived neurotrophic factor release, CB1 protein expression, and ERK levels was evaluated. The involvement of CB1 modulation was verified by the cotreatment with the CB1 antagonist AM4113...
September 27, 2022: Fitoterapia
https://read.qxmd.com/read/36048545/intra-accumbal-d1-but-not-d2-like-dopamine-receptor-antagonism-reverses-the-inhibitory-effects-of-cannabidiol-on-extinction-and-reinstatement-of-methamphetamine-seeking-behavior-in-rats
#13
JOURNAL ARTICLE
Mahboobeh Mirmohammadi, Kiarash Eskandari, Morteza Koruji, Ronak Shabani, Reza Ahadi, Abbas Haghparast
Introduction: Methamphetamine (METH) is an addictive psychostimulant that facilitates dopamine transmission to the nucleus accumbens (NAc), resulting in alterations in the mesocorticolimbic brain regions. Cannabidiol (CBD) is considered the second most abundant component of cannabis and is believed to decrease the METH effects. Reversing psychostimulant-induced abnormalities in the mesolimbic dopamine system is the main mechanism for this effect. Various other mechanisms have been proposed: increasing endocannabinoid system activity and modulating gamma-aminobutyric acid (GABA) and glutamate neurons in NAc...
September 1, 2022: Cannabis and Cannabinoid Research
https://read.qxmd.com/read/35665872/the-modulatory-effects-of-alkaloid-extracts-of-cannabis-sativa-datura-stramonium-nicotiana-tabacum-and-male-carica-papaya-on-neurotransmitter-neurotrophic-and-neuroinflammatory-systems-linked-to-anxiety-and-depression
#14
JOURNAL ARTICLE
Olamide Wilson Fasakin, Ganiyu Oboh, Ayokunle Olubode Ademosun, Akeem O Lawal
This study investigated the modulatory effects of alkaloid extracts of Cannabis sativa (CSAE), Datura stramonium (DSAE), Nicotiana tabacum (NTAE) and male Carica papaya (CMAE) on neurotransmitter, neurotrophic and neuro-inflammatory systems linked to anxiety and depression. Male Wistar rats were orally administered the alkaloid extracts in doses of 5, 50, 500, and 2000 mg/kg for 90 days. On day 91, neurobehavioural studies were evaluated, rats were sacrificed, brain hippocampus removed and tissue homogenate prepared...
June 5, 2022: Inflammopharmacology
https://read.qxmd.com/read/35653401/the-relationship-between-cannabis-use-and-taurine-a-mrs-and-metabolomics-study
#15
JOURNAL ARTICLE
Sharlene D Newman, Ashley M Schnakenberg Martin, David Raymond, Hu Cheng, Landon Wilson, Stephen Barnes, Brian F O'Donnell
Taurine is an essential amino acid. It has been shown to be neuroprotective including protecting against the neurotoxic effects of glutamate. The goal of the current study was to examine the relationship between CB use and taurine measured in brain using magnetic resonance spectroscopy (MRS), and peripherally from a urine sample. Two experiments are presented. The first is a reanalysis of published data that examined taurine and glutamate in the dorsal anterior cingulate of a CB user group and non-user group using MRS...
2022: PloS One
https://read.qxmd.com/read/35639364/effects-of-tetrahydrocannabinol-and-cannabidiol-on-brain-derived-neurotrophic-factor-and-tropomyosin-receptor-kinase-b-expression-in-the-adolescent-hippocampus
#16
JOURNAL ARTICLE
Joanna Winstone, Hana Shafique, Madeleine E Clemmer, Ken Mackie, Jim Wager-Miller
Introduction: Adolescence is an important phase in brain maturation, specifically it is a time during which weak synapses are pruned and neural pathways are strengthened. Adolescence is also a time of experimentation with drugs, including cannabis, which may have detrimental effects on the developing nervous system. The cannabinoid type 1 receptor (CB1 ) is an important modulator of neurotransmitter release and plays a central role in neural development. Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), are also critical during development for axon guidance and synapse specification...
May 30, 2022: Cannabis and Cannabinoid Research
https://read.qxmd.com/read/35133644/cannabis-and-cannabinoids-pharmacology-and-therapeutic-potential
#17
JOURNAL ARTICLE
Małgorzata Śmiarowska, Monika Białecka, Anna Machoy-Mokrzyńska
INTRODUCTION: Cannabis (also known as marijuana) is the most frequently used psychoactive substance in the world. The role of cannabis in medicine is rapidly evolving, and advances in the understanding of its pharmacology have led to numerous proposed uses of these drugs. STATE OF THE ART: Cannabis contains Δ9-tetrahydrocannabinol and cannabidiol as the primary constituents responsible for pharmacological activity. It is now known that there are at least two types of cannabinoid receptors...
2022: Neurologia i Neurochirurgia Polska
https://read.qxmd.com/read/34645786/behavioral-aspects-and-neurobiological-properties-underlying-medical-cannabis-treatment-in-shank3-mouse-model-of-autism-spectrum-disorder
#18
JOURNAL ARTICLE
Shani Poleg, Emad Kourieh, Angela Ruban, Guy Shapira, Noam Shomron, Boaz Barak, Daniel Offen
Autism spectrum disorder (ASD) is a neurodevelopmental disease with a wide spectrum of manifestation. The core symptoms of ASD are persistent deficits in social communication, and restricted and repetitive patterns of behavior, interests, or activities. These are often accompanied by intellectual disabilities. At present, there is no designated effective treatment for the core symptoms and co-morbidities of ASD. Recently, interest is rising in medical cannabis as a treatment for ASD, with promising clinical data...
October 13, 2021: Translational Psychiatry
https://read.qxmd.com/read/34390300/results-from-a-randomized-double-blind-placebo-controlled-crossover-multimodal-mri-pilot-study-of-gabapentin-for-co-occurring-bipolar-and-cannabis-use-disorders
#19
RANDOMIZED CONTROLLED TRIAL
James J Prisciandaro, William Mellick, Lindsay M Squeglia, Sara Hix, Lauren Arnold, Bryan K Tolliver
Disrupted brain gamma-aminobutyric acid (GABA)/glutamate homeostasis is a promising target for pharmacological intervention in co-occurring bipolar disorder (BD) and cannabis use disorder (CUD). Gabapentin is a safe and well-tolerated medication, FDA-approved to treat other neurological diseases, that restores GABA/glutamate homeostasis, with treatment studies supporting efficacy in treating CUD, as well as anxiety and sleep disorders that are common to both BD and CUD. The present manuscript represents the primary report of a randomized, double-blind, placebo-controlled, crossover (1-week/condition), multimodal-MRI (proton-MR spectroscopy, functional MRI) pilot study of gabapentin (1200 mg/day) in BD + CUD (n = 22)...
January 2022: Addiction Biology
https://read.qxmd.com/read/34389427/adolescent-exposure-to-delta-9-tetrahydrocannabinol-and-ethanol-heightens-sensitivity-to-fear-stimuli
#20
JOURNAL ARTICLE
Cora E Smiley, Heyam K Saleh, Katherine E Nimchuk, Constanza Garcia-Keller, Justin T Gass
Cannabis use disorder (CUD) has doubled in prevalence over the past decade as a nation-wide trend toward legalization allows for increased drug accessibility. As a result, marijuana has become the most commonly used illicit drug in the United States particularly among the adolescent population. This is especially concerning since there is greater risk for the harmful side effects of drug use during this developmental period due to ongoing brain maturation. Increasing evidence indicates that CUD often occurs along with other debilitating conditions including both alcohol use disorder (AUD) and anxiety disorders such post-traumatic stress disorder (PTSD)...
October 11, 2021: Behavioural Brain Research
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