Aline Ignacio, Marcella Cipelli, Tatiane Takiishi, Cristhiane Favero Aguiar, Fernanda Fernandes Terra, Bruno Ghirotto, Eloisa Martins Silva, Angela Castoldi, Yuli Thamires Magalhães, Tiago Antonio, Barbara Nunes Padovani, Meire Ioshie Hiyane, Vinicius Andrade-Oliveira, Fabio Luis Forti, Niels Olsen Saraiva Camara
The Mammalian Target of Rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation of their metabolic status. By specific deletion of Rictor in CD11c+ myeloid cells (referred to here as CD11cRicΔ/Δ), this study investigated the role of mTOR complex 2 (mTORC2) signalling in dendritic cells (DCs) function in mice. We showed that upon DSS-induced colitis, lack of mTORC2 signalling CD11c+ cells diminishes colitis score, and abrogates dendritic cell (DC) migration to the mesenteric lymph nodes (MLN), thereby diminishing the infiltration of T helper (Th) 17 cells in the lamina propria (LP) and subsequent inflammation...
April 23, 2024: Journal of Leukocyte Biology