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https://www.readbyqxmd.com/read/29053813/comparative-transcriptomic-analysis-of-high-and-low-egg-producing-duck-ovaries
#1
Z Tao, W Song, C Zhu, W Xu, H Liu, S Zhang, Li Huifang
The egg-laying rate is an important indicator of egg production of laying ducks. Egg production directly impacts the economic benefits of the duck industry. In order to obtain better insight into the molecular mechanisms associated with the process of egg production, comparative transcriptomic analysis of the ovaries of Jinding ducks with high and low egg production was performed using the Illumina HiSeq 2500 system. A total of 843 differentially expressed genes (DEGs) was identified, 367 that were down-regulated and 476 that were up-regulated in high egg production (HEP) ovaries, as compared with low egg production (LEP) ovaries...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053066/different-times-of-day-do-not-change-heart-rate-variability-recovery-after-light-exercise-in-sedentary-subjects-24%C3%A2-hours-holter-monitoring
#2
Eliza Prodel, Tiago Peçanha, Lilian Pinto Da Silva, Rogério Baumgratz De Paula, Daniel Godoy Martinez, Jorge Roberto Perrout De Lima, Mateus Camaroti Laterza
Incidence of cardiovascular events follows a circadian rhythm with peak occurrence during morning. Disturbance of autonomic control caused by exercise had raised the question of the safety in morning exercise and its recovery. Furthermore, we sought to investigate whether light aerobic exercise performed at night would increase HR and decrease HRV during sleep. Therefore, the aim of this study was to test the hypothesis that morning exercise would delay HR and HRV recovery after light aerobic exercise, additionally, we tested the impact of late night light aerobic exercise on HR and HRV during sleep in sedentary subjects...
October 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29053034/circadian-rest-activity-rhythm-in-chronic-obstructive-pulmonary-disease
#3
Deuzilane Muniz Nunes, Bruno S B Gonçalves, Carina Aparecida Tardelli Peixoto, Veralice Meireles Sales De Bruin, Fernando Mazzilli Louzada, Pedro Felipe Carvalhedo De Bruin
To characterize circadian rest-activity rhythm in COPD, 26 cases (66.9 ± 8.5y) and 15 controls (63.0 ± 10.7y) were assessed by actimetry. Rhythm fragmentation was measured by intradaily variability (IV), while synchronization to the 24-h light-dark cycle was measured by interdaily stability (IS). The average activity during the least active 5-h period (L5) and the average activity during the most active 10-h period (M10) were used to calculate the relative amplitude mean [RAm = (M10-L5)/(M10+L5)]. COPD patients presented higher IVm (0...
October 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29052517/constitutive-expression-of-osdof4-encoding-a-c2-c2-zinc-finger-transcription-factor-confesses-its-distinct-flowering-effects-under-long-and-short-day-photoperiods-in-rice-oryza-sativa-l
#4
Qi Wu, Xue Liu, Dedong Yin, Hua Yuan, Qi Xie, Xianfeng Zhao, Xiaobing Li, Lihuang Zhu, Shigui Li, Dayong Li
BACKGROUND: Dof (DNA binding with one finger) proteins, a class of plant-specific transcription factors which contain a conserved C2-C2-type zinc finger domain, are involved in many fundamental processes. In the Arabidopsis photoperiod response pathway, CDF (CYCLING DOF FACTOR) proteins have a primary role as acting via transcriptional repression of the direct FLOWERING LOCUS T (FT) activator CONSTANS (CO). Our previous study indicated that one of CDF homologs, OsDOf12, was involved in photoperiodic flowering...
October 19, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29052505/transcriptome-assembly-in-suaeda-aralocaspica-to-reveal-the-distinct-temporal-gene-mirna-alterations-between-the-dimorphic-seeds-during-germination
#5
Lei Wang, Hong-Ling Wang, Lan Yin, Chang-Yan Tian
BACKGROUND: Dimorphic seeds from Suaeda aralocaspica exhibit different germination behaviors that are thought to be a bet-hedging strategy advantageous in harsh and unpredictable environments. To understand the molecular mechanisms of Suaeda aralocaspica dimorphic seed germination, we applied RNA sequencing and small RNA sequencing for samples collected at three germination stages. RESULTS: A total of 79,414 transcripts were assembled using Trinity, of which 57...
October 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29050555/natural-variation-in-human-clocks
#6
Malcolm von Schantz
Our own species has a diurnal activity pattern and an average circadian period of 24.2h. Exact determination of circadian period requires expensive and intrusive protocols, and investigators are therefore using chronotype questionnaires as a proxy quantitative measure. Both measures show a normal distribution suggestive of a polygenic trait. The genetic components of the 24-h feedback loop that generates circadian rhythms within our cells have been mapped in detail, identifying a number of candidate genes which have been investigated for genetic polymorphisms relating to the phenotypic variance...
2017: Advances in Genetics
https://www.readbyqxmd.com/read/29049138/graph-theoretical-analysis-of-genome-scale-data-examination-of-gene-activation-occurring-in-the-setting-of-community-acquired-pneumonia
#7
Octavia M Peck Palmer, Gary Rogers, Sachin Yende, Derek C Angus, Michael A Langston, Gilles Clermont
INTRODUCTION: We have previously reported evidence that black individuals appear to have a significantly higher incidence of infection-related hospitalizations compared to white individuals. It is possible that the host immune response is responsible for this vital difference. In support such a hypothesis, the aim of this study was to determine whether black and white individuals exhibit differential whole blood gene network activation. METHODS: We examined whole blood network activation in a subset of patients (n = 22 pairs, propensity score matched (1:1) black and white patients) with community-acquired pneumonia (CAP) from the Genetic and Inflammatory Markers of Sepsis study...
October 18, 2017: Shock
https://www.readbyqxmd.com/read/29049001/effects-of-melatonin-on-mechanisms-involved-in-hypertension-using-human-umbilical-vein-endothelial-cells
#8
Guangfang Shao, Suping Zhang, Jihua Nie, Jianxiang Li, Jian Tong
Changes in diurnal rhythmicity in blood pressure (BP) are associated with hypertension and consequent cardiovascular damage. The involvement of diurnal rhythmicity as a pathogenic factor in hypertension is not fully understood. Since the hormone melatonin (MLT) regulates circadian rhythm, it was also of interest to determine whether this hormone played a role in hypertension-related alterations in circadian rhythm. Thus the aim of this study was to examine the mechanisms underlying MLT-mediated antihypertension...
October 19, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29046483/deficiency-of-shank2-causes-mania-like-behavior-that-responds-to-mood-stabilizers
#9
Andrea L Pappas, Alexandra L Bey, Xiaoming Wang, Mark Rossi, Yong Ho Kim, Haidun Yan, Fiona Porkka, Lara J Duffney, Samantha M Phillips, Xinyu Cao, Jin-Dong Ding, Ramona M Rodriguiz, Henry H Yin, Richard J Weinberg, Ru-Rong Ji, William C Wetsel, Yong-Hui Jiang
Genetic defects in the synaptic scaffolding protein gene, SHANK2, are linked to a variety of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, intellectual disability, and bipolar disorder, but the molecular mechanisms underlying the pleotropic effects of SHANK2 mutations are poorly understood. We generated and characterized a line of Shank2 mutant mice by deleting exon 24 (Δe24). Shank2Δe24-/- mice engage in significantly increased locomotor activity, display abnormal reward-seeking behavior, are anhedonic, have perturbations in circadian rhythms, and show deficits in social and cognitive behaviors...
October 19, 2017: JCI Insight
https://www.readbyqxmd.com/read/29045837/the-circadian-clock-gene-bmal1-controls-thyroid-hormone-mediated-spectral-identity-and-cone-photoreceptor-function
#10
Onkar B Sawant, Amanda M Horton, Olivia F Zucaro, Ricky Chan, Vera L Bonilha, Ivy S Samuels, Sujata Rao
Circadian clocks regulate various aspects of photoreceptor physiology, but their contribution to photoreceptor development and function is unclear. Cone photoreceptors are critical for color vision. Here, we define the molecular function of circadian activity within cone photoreceptors and reveal a role for the clock genes Bmal1 and Per2 in regulating cone spectral identity. ChIP analysis revealed that BMAL1 binds to the promoter region of the thyroid hormone (TH)-activating enzyme type 2 iodothyronine deiodinase (Dio2) and thus regulates the expression of Dio2...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29044737/chronic-bmy7378-treatment-alters-behavioral-circadian-rhythms
#11
Jhenkruthi Vijaya Shankara, Angélique Orr, Richelle Mychasiuk, Michael C Antle
The mammalian circadian clock is synchronized to the day:night cycle by light. Serotonin modulates the circadian effects of light, with agonists inhibiting response to light and antagonists enhancing responses to light. A special class of serotonergic compounds, the mixed 5-HT1A agonist/antagonists, potentiate light-induced phase advances by up to 400% when administered acutely. In this study, we examine the effects of one of these mixed 5-HT1A agonist/antagonists, BMY7378, when administered chronically. Thirty adult male hamsters were administered either vehicle or BMY7378 via surgically implanted osmotic minipumps over a period of 28 days...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29043393/characterization-of-a-set-of-abdominal-neuroendocrine-cells-that-regulate-stress-physiology-using-colocalized-diuretic-peptides-in-drosophila
#12
Meet Zandawala, Richard Marley, Shireen A Davies, Dick R Nässel
Multiple neuropeptides are known to regulate water and ion balance in Drosophila melanogaster. Several of these peptides also have other functions in physiology and behavior. Examples are corticotropin-releasing factor-like diuretic hormone (diuretic hormone 44; DH44) and leucokinin (LK), both of which induce fluid secretion by Malpighian tubules (MTs), but also regulate stress responses, feeding, circadian activity and other behaviors. Here, we investigated the functional relations between the LK and DH44 signaling systems...
October 17, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29040758/linking-light-exposure-and-subsequent-sleep-a-field-polysomnography-study-in-humans
#13
Emma J Wams, Tom Woelders, Irene Marring, Laura van Rosmalen, Domien G M Beersma, Marijke C M Gordijn, Roelof A Hut
Study objectives: To determine the effect of light exposure on subsequent sleep characteristics under ambulatory field conditions. Methods: Twenty healthy participants were fitted with ambulatory PSG and wrist-actigraphs to assess light exposure, rest-activity, sleep quality, timing and architecture. Laboratory salivary dim-light melatonin onset (DLMO) was analyzed to determine endogenous circadian phase. Results: Later circadian clock phase was associated with lower intensity (R2=0...
October 11, 2017: Sleep
https://www.readbyqxmd.com/read/29039977/chronic-disruptions-of-circadian-sleep-regulation-induce-specific-proinflammatory-responses-in-the-rat-colon
#14
Lenka Polidarová, Pavel Houdek, Alena Sumová
Exposure to environmental conditions that disturb the daily rhythms has been shown to enhance the proinflammatory responses of immunostimulant-challenged immune system. However, it is not known whether circadian disturbances may stimulate unchallenged immune responses and thus contribute per se to the development of inflammation-related diseases. Our aim was to ascertain an effect of various conditions threatening the behavioral activity/rest cycle regulation, namely aging with or without melatonin, 6 h advance/delay phase shifts in the light/dark cycle repeated with a 2-day frequency and constant light, on expression of immune markers in the rat colon...
October 17, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29038116/design-principles-of-phosphorylation-dependent-timekeeping-in-eukaryotic-circadian-clocks
#15
Koji L Ode, Hiroki R Ueda
The circadian clock in cyanobacteria employs a posttranslational oscillator composed of a sequential phosphorylation-dephosphorylation cycle of KaiC protein, in which the dynamics of protein structural changes driven by temperature-compensated KaiC's ATPase activity are critical for determining the period. On the other hand, circadian clocks in eukaryotes employ transcriptional feedback loops as a core mechanism. In this system, the dynamics of protein accumulation and degradation affect the circadian period...
October 16, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/29037208/light-dark-phase-dependent-spontaneous-activity-is-maintained-in-dopamine-deficient-mice
#16
Masayo Fujita, Yoko Hagino, Taishi Takeda, Shinya Kasai, Miho Tanaka, Yukio Takamatsu, Kazuto Kobayashi, Kazutaka Ikeda
Dopamine is important for motor control and involved in the regulation of circadian rhythm. We previously found that dopamine-deficient (DD) mice became hyperactive in a novel environment 72 h after the last injection of L-3,4-dihydroxyphenylalanine (L-DOPA) when dopamine was almost completely depleted. DD mice did not initially exhibit hyperactivity in their home cages, but the animals exhibited hyperactivity several hours after the last L-DOPA injection. The regulation of motor activity in a novel environment and in home cages may be different...
October 16, 2017: Molecular Brain
https://www.readbyqxmd.com/read/29037131/gene-regulation-and-signal-transduction-in-the-ice-cbf-cor-signaling-pathway-during-cold-stress-in-plants
#17
REVIEW
Da-Zhi Wang, Ya-Nan Jin, Xi-Han Ding, Wen-Jia Wang, Shan-Shan Zhai, Li-Ping Bai, Zhi-Fu Guo
Low temperature is an abiotic stress that adversely affects the growth and production of plants. Resistance and adaptation of plants to cold stress is dependent upon the activation of molecular networks and pathways involved in signal transduction and the regulation of cold-stress related genes. Because it has numerous and complex genes, regulation factors, and pathways, research on the ICE-CBF-COR signaling pathway is the most studied and detailed, which is thought to be rather important for cold resistance of plants...
October 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29035710/blunted-basal-corticosterone-pulsatility-predicts-post-exposure-susceptibility-to-ptsd-phenotype-in-rats
#18
Dor Danan, Michael A Matar, Zeev Kaplan, Joseph Zohar, Hagit Cohen
The basal activity of the hypothalamic-pituitary-adrenal axis is highly dynamic and is characterized by both circadian and ultradian (pulsatile) patterns of hormone secretion. Pulsatility of glucocorticoids has been determined to be critical for optimal transcriptional, neuroendocrine, and behavioral responses. We used an animal model of post-traumatic stress disorder (PTSD) to assess whether stress-induced impairment of behavioral responses is correlated with aberrant secretion of corticosterone. Serial blood samples were collected manually via the jugular vein cannula during the light-(inactive)-phase in conscious male rats at 20-min intervals for a period of 5h before and 6...
October 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29035315/breaking-up-sitting-with-light-intensity-physical-activity-implications-for-shift-workers
#19
Grace E Vincent, Sarah M Jay, Corneel Vandelanotte, Sally A Ferguson
Prolonged sitting, restricted sleep, and circadian disruption are all independent risk factors for non-communicable diseases. Previous research has demonstrated that breaking up sitting with light-intensity physical activity has clear benefits for the health of day workers, but these findings may not apply in the presence of sleep restriction and/or circadian disruption-both of which are commonly experienced by shift-workers. Specifically, sleep restriction, and circadian disruption result in acute physiological changes that may offset the benefits of breaking up sitting...
October 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29032081/protein-malnutrition-after-weaning-disrupts-peripheral-clock-and-daily-insulin-secretion-in-mice
#20
Patricia Cristine Borck, Thiago Martins Batista, Jean Franciesco Vettorazzi, Rafael Ludemann Camargo, Antonio Carlos Boschero, Elaine Vieira, Everardo Magalhães Carneiro
Changes in nutritional state may alter circadian rhythms through alterations in expression of clock genes. Protein deficiency has a profound effect on body metabolism, but the effect of this nutrient restriction after weaning on biological clock has not been explored. Thus, this study aims to investigate whether the protein restriction affects the daily oscillation in the behavior and metabolic rhythms, as well as expression of clock genes in peripheral tissues. Male C57BL/6 J mice, after weaning, were fed a normal-protein (NP) diet or a low-protein (LP) diet for 8 weeks...
September 4, 2017: Journal of Nutritional Biochemistry
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