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Circadian activity

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https://www.readbyqxmd.com/read/28098888/hclock-induction-by-hypoxia-promotes-inflammatory-responses-by-activating-the-nf%C3%A2-%C3%AE%C2%BAb-pathway
#1
Xiao Tang, Daqiao Guo, Changpo Lin, Zhenyu Shi, Ruizhe Qian, Weiguo Fu, Jianjun Liu, Xu Li, Longhua Fan
The expression and secretion of infla-mmation‑associated cytokines are induced by hypoxia. Circadian locomotor output cycles protein kaput (CLOCK) has previously been shown to activate the nuclear factor‑κB (NF‑κB) pathway, which is a key transcription factor during hypoxia. The present study evaluated the role of the NF‑κB pathway in the CLOCK‑induced inflammatory response. Under hypoxic conditions, the expression levels of NF‑κB and proinflammatory cytokines, including interleukin (IL)‑1, IL‑1β, IL‑6, intercellular adhesion molecule 1, cyclooxygenase 2 and tumor necrosis factor alpha, were significantly increased compared with under control conditions...
January 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28098350/endogenous-circadian-rhythms-in-pigment-composition-induce-changes-in-photochemical-efficiency-in-plant-canopies
#2
José Ignacio García-Plazaola, Beatriz Fernández-Marín, Juan Pedro Ferrio, Josu G Alday, Günter Hoch, Damien Landais, Alexandru Milcu, David T Tissue, Jordi Voltas, Arthur Gessler, Jacques Roy, Víctor Resco de Dios
There is increasing evidence that the circadian clock is a significant driver of photosynthesis that becomes apparent when environmental cues are experimentally held constant. We studied whether the composition of photosynthetic pigments is under circadian regulation, and whether pigment oscillations lead to rhythmic changes in photochemical efficiency. To address these questions, canopies of bean and cotton were maintained, after an entrainment phase, under constant (light or darkness) conditions for 30-48 h...
January 18, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28092655/circadian-and-upr-dependent-control-of-cpeb4-mediates-a-translational-response-to-counteract-hepatic-steatosis-under-er-stress
#3
Carlos Maillo, Judit Martín, David Sebastián, Maribel Hernández-Alvarez, Mar García-Rocha, Oscar Reina, Antonio Zorzano, Mercedes Fernandez, Raúl Méndez
The cytoplasmic polyadenylation element-binding (CPEB) proteins regulate pre-mRNA processing and translation of CPE-containing mRNAs in early embryonic development and synaptic activity. However, specific functions in adult organisms are poorly understood. Here we show that CPEB4 is required for adaptation to high-fat-diet- and ageing-induced endoplasmic reticulum (ER) stress, and subsequent hepatosteatosis. Stress-activated liver CPEB4 expression is dual-mode regulated. First, Cpeb4 mRNA transcription is controlled by the circadian clock, and then its translation is regulated by the unfolded protein response (UPR) through upstream open reading frames within the 5'UTR...
January 16, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28090585/circadian-forced-desynchrony-of-the-master-clock-leads-to-phenotypic-manifestation-of-depression-in-rats
#4
Miriam Ben-Hamo, Tracy A Larson, Leanne S Duge, Carl Sikkema, Charles W Wilkinson, Horacio O de la Iglesia, Mónica M C González
In mammals, a master circadian clock within the suprachiasmatic nucleus (SCN) of the hypothalamus maintains the phase coherence among a wide array of behavioral and physiological circadian rhythms. Affective disorders are typically associated with disruption of this fine-tuned "internal synchronization," but whether this internal misalignment is part of the physiopathology of mood disorders is not clear. To date, depressive-like behavior in animal models has been induced by methods that fail to specifically target the SCN regulation of internal synchronization as the mode to generate depression...
November 2016: ENeuro
https://www.readbyqxmd.com/read/28088873/developmental-changes-in-ultradian-sleep-cycles-across-early-childhood
#5
Sean Lopp, William Navidi, Peter Achermann, Monique LeBourgeois, Cecilia Diniz Behn
Nocturnal human sleep is composed of cycles between rapid eye movement (REM) sleep and non-REM (NREM) sleep. In adults, the structure of ultradian cycles between NREM and REM sleep is well characterized; however, less is known about the developmental trajectories of ultradian sleep cycles across early childhood. Cross-sectional studies indicate that the rapid ultradian cycling of active-quiet sleep in infancy shifts to a more adult-like pattern of NREM-REM sleep cycling by the school-age years, yet longitudinal studies elucidating the details of this transition are scarce...
January 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28087932/the-complexity-of-fungal-vision
#6
Reinhard Fischer, Jesus Aguirre, Alfredo Herrera-Estrella, Luis M Corrochano
Life, as we know it, would not be possible without light. Light is not only a primary source of energy, but also an important source of information for many organisms. To sense light, only a few photoreceptor systems have developed during evolution. They are all based on an organic molecule with conjugated double bonds that allows energy transfer from visible (or UV) light to its cognate protein to translate the primary physical photoresponse to cell-biological actions. The three main classes of receptors are flavin-based blue-light, retinal-based green-light (such as rhodopsin), and linear tetrapyrrole-based red-light sensors...
December 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28081144/digital-health-tracking-physiomes-and-activity-using-wearable-biosensors-reveals-useful-health-related-information
#7
Xiao Li, Jessilyn Dunn, Denis Salins, Gao Zhou, Wenyu Zhou, Sophia Miryam Schüssler-Fiorenza Rose, Dalia Perelman, Elizabeth Colbert, Ryan Runge, Shannon Rego, Ria Sonecha, Somalee Datta, Tracey McLaughlin, Michael P Snyder
A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recording over 250,000 daily measurements for up to 43 individuals, we found personalized circadian differences in physiological parameters, replicating previous physiological findings. Interestingly, we found striking changes in particular environments, such as airline flights (decreased peripheral capillary oxygen saturation [SpO2] and increased radiation exposure)...
January 2017: PLoS Biology
https://www.readbyqxmd.com/read/28079162/glucose-tolerance-in-mice-exposed-to-light-dark-stimulus-patterns-mirroring-dayshift-and-rotating-shift-schedules
#8
Mariana G Figueiro, Leora Radetsky, Barbara Plitnick, Mark S Rea
Glucose tolerance was measured in (nocturnal) mice exposed to light-dark stimulus patterns simulating those that (diurnal) humans would experience while working dayshift (DSS) and 2 rotating night shift patterns (1 rotating night shift per week [RSS1] and 3 rotating night shifts per week [RSS3]). Oral glucose tolerance tests were administered at the same time and light phase during the third week of each experimental session. In contrast to the RSS1 and RSS3 conditions, glucose levels reduced more quickly for the DSS condition...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076831/dosing-time-dependent-oxidative-effects-of-an-immunosuppressive-drug-mycophenolate-mofetil-on-rat-kidneys
#9
Ichrak Dridi, Wafa Ben-Cherif, Hassiba Chahdoura, Zohra Haouas, Mossadok Ben-Attia, Karim Aouam, Alain Reinberg, Naceur A Boughattas
This study investigates whether the toxicity in kidneys as well as oxidative stress varied according to the dosing time of an immunosuppressive agent "mycophenolate mofetil (MMF)" in Wistar Rat. 300mg/kg of MMF was injected by intraperitonal at four different circadian stages (1, 7, 13 and 19h after light onset, HALO). Rats were sacrificed after 3days, and the kidneys were removed for determination of oxidative stress and histological analysis. Biochemical variable (creatinine, urea) was performed. Statistical analysis showed that MMF administration at 7 HALO produced a renal toxicity assessed by the significant increase in both blood creatinine and urea and antioxidant activity assessed by malondialdehyde and protein carbonyl levels indicating an induction of lipid peroxidation in oxidative damage...
January 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28076642/activity-rest-rhythm-of-depressed-adolescents-undergoing-therapy-case-studies
#10
Maria Eugênia Mesquita, Maria Eliza Finazzi, Bruno Gonçalves, Lee Fu-I, Leandro L Duarte, José Ricardo Lopes, José Alberto Del-Porto, Luiz Menna-Barreto
Introduction: Disorders of circadian rhythms have been reported in studies of both depressed children and of depressed adolescents. The aim of this study was to evaluate whether there is a relationship between the 24-hour spectral power (24h SP) of the activity/rest rhythm and the clinical course of depression in adolescents. Methods: Six 14 to 17-year-old adolescents were recruited for the study. They were all suffering from major depressive disorder, according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria, as identified by the Schedule for Affective Disorders and Schizophrenia for School Aged Children: Present and Lifetime Version (K-SADS-PL)...
October 2016: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28074036/redox-crisis-underlies-conditional-light-dark-lethality-in-cyanobacterial-mutants-that-lack-the-circadian-regulator-rpaa
#11
Spencer Diamond, Benjamin E Rubin, Ryan K Shultzaberger, You Chen, Chase D Barber, Susan S Golden
Cyanobacteria evolved a robust circadian clock, which has a profound influence on fitness and metabolism under daily light-dark (LD) cycles. In the model cyanobacterium Synechococcus elongatus PCC 7942, a functional clock is not required for diurnal growth, but mutants defective for the response regulator that mediates transcriptional rhythms in the wild-type, regulator of phycobilisome association A (RpaA), cannot be cultured under LD conditions. We found that rpaA-null mutants are inviable after several hours in the dark and compared the metabolomes of wild-type and rpaA-null strains to identify the source of lethality...
January 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28072877/motor-cortex-theta-and-gamma-architecture-in-young-adult-appsweps1de9-alzheimer-mice
#12
Anna Papazoglou, Julien Soos, Andreas Lundt, Carola Wormuth, Varun Raj Ginde, Ralf Müller, Christina Henseler, Karl Broich, Kan Xie, Britta Haenisch, Dan Ehninger, Marco Weiergräber
Alzheimer's disease (AD) is a multifactorial disorder leading to progressive memory loss and eventually death. In this study, an APPswePS1dE9 AD mouse model has been analyzed for motor cortex theta, beta and gamma frequency alterations using computerized 3D stereotaxic electrode positioning and implantable video-EEG radiotelemetry to perform long-term M1 recordings from both genders considering age, circadian rhythm and activity status of experimental animals. We previously demonstrated that APPswePS1dE9 mice exibit complex alterations in hippocampal frequency power and another recent investigation reported a global increase of alpha, beta and gamma power in APPswePS1dE9 in females of 16-17 weeks of age...
2017: PloS One
https://www.readbyqxmd.com/read/28063234/hadza-sleep-biology-evidence-for-flexible-sleep-wake-patterns-in-hunter-gatherers
#13
David R Samson, Alyssa N Crittenden, Ibrahim A Mabulla, Audax Z P Mabulla, Charles L Nunn
OBJECTIVES: Cross-cultural sleep research is critical to deciphering whether modern sleep expression is the product of recent selective pressures, or an example of evolutionary mismatch to ancestral sleep ecology. We worked with the Hadza, an equatorial, hunter-gatherer community in Tanzania, to better understand ancestral sleep patterns and to test hypotheses related to sleep segmentation. METHODS: We used actigraphy to analyze sleep-wake patterns in thirty-three volunteers for a total of 393 days...
January 7, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28063156/effect-of-a-selective-sglt2-inhibitor-luseogliflozin-on-circadian-rhythm-of-sympathetic-nervous-function-and-locomotor-activities-in-metabolic-syndrome-rats
#14
Asadur Rahman, Yoshihide Fujisawa, Daisuke Nakano, Hirofumi Hitomi, Akira Nishiyama
Metabolic syndrome is often associated with disruption of circadian rhythm of systemic hemodynamics and cardiovascular disease. Experiments were conducted to investigate the effects of luseogliflozin, a selective SGLT2 inhibitor, on circadian rhythm of sympathetic nervous function and locomotor activity (LA) in metabolic syndrome rats. The difference in the low frequency component of systolic blood pressure between the dark and light period significantly increased in the luseogliflozin-treated SHRcp. LA also increased in the dark period compared with the light period following luseogliflozin treatment...
January 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28060532/critical-slowing-down-as-an-early-warning-of-transitions-in-episodes-of-bipolar-disorder-a-simulation-study-based-on-a-computational-model-of-circadian-activity-rhythms
#15
Atiyeh Bayani, Fatemeh Hadaeghi, Sajad Jafari, Greg Murray
Bipolar disorder is characterized by repeated episodes of mania and depression, and can be understood as pathological complex system behaviour involving cognitive, affective and psychomotor disturbance. Accurate prediction of episode transitions in the long-term pattern of mood changes in bipolar disorder could improve the management of the disorder by providing an objective early warning of relapse. In particular, circadian activity changes measured via actigraphy may contain clinically relevant signals of imminent systemic dysregulation...
January 6, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28060525/diurnal-rhythms-in-psychological-reward-functioning-in-healthy-young-men-wanting-liking-and-learning
#16
Jamie E M Byrne, Greg Murray
A range of evidence suggests that human reward functioning is partly driven by the endogenous circadian system, generating 24-hour rhythms in behavioural measures of reward activation. Reward functioning is multifaceted but literature to date is largely limited to measures of self-reported positive mood states. The aim of this study was to advance the field by testing for hypothesised diurnal variation in previously unexplored components of psychological reward: 'wanting', liking, and learning using subjective and behavioural measures...
January 6, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28057529/genetic-inhibition-of-anaplastic-lymphoma-kinase-rescues-cognitive-impairments-in-neurofibromatosis-1-mutant-mice
#17
Joseph B Weiss, Sydney J Weber, Eileen Ruth S Torres, Tessa Marzulla, Jacob Raber
Heterozygous Neurofibromatosis 1 (NF1) loss of function mutations occur in approximately 90% of patients with neurofibromatosis. A major, disabling phenotypic consequence of reduced NF1 function is cognitive impairment; a possibly related behavioral phenotype is impaired sleep. Recent results in Drosophila have demonstrated a genetic interaction between Anaplastic Lymphoma Kinase (Alk) and NF1 for both associative learning and sleep. Inhibition of Alk improves associative learning and sleep in heterozygous NF1 mutant flies...
January 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28057520/molecular-basis-for-the-regulation-of-the-circadian-clock-kinases-ck1%C3%AE-and-ck1%C3%AE%C2%B5
#18
REVIEW
Yu Yang, Tingting Xu, Yunfei Zhang, Ximing Qin
CK1δ and CK1ε are unique in the casein kinase 1 family and play critical roles in a number of physiological intracellular pathways. In particular, these kinases are involved in composing the mammalian circadian clock by phosphorylating core clock proteins. Considering that CK1δ/ε phosphorylate other key biological molecules, such as β-catenin and p53, understanding how the kinase activity is regulated would be greatly significant, since they are potential targets to develop pharmacological agents against cancer, pain, and circadian disorders...
January 3, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28052921/the-circadian-oscillator-of-the-cerebral-cortex-molecular-biochemical-and-behavioral-effects-of-deleting-the-arntl-clock-gene-in-cortical-neurons
#19
Tenna Bering, Mikkel Bloss Carstensen, Gitta Wörtwein, Pia Weikop, Martin Fredensborg Rath
A molecular circadian oscillator resides in neurons of the cerebral cortex, but its role is unknown. Using the Cre-LoxP method, we have here abolished the core clock gene Arntl in those neurons. This mouse represents the first model carrying a deletion of a circadian clock component specifically in an extrahypothalamic cell type of the brain. Molecular analyses of clock gene expression in the cerebral cortex of the Arntl conditional knockout mouse revealed disrupted circadian expression profiles, whereas clock gene expression in the suprachiasmatic nucleus was still rhythmic, thus showing that Arntl is required for normal function of the cortical circadian oscillator...
January 3, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28052040/nuclear-receptor-retinoid-related-orphan-receptor-alpha-promotes-apoptosis-but-is-reduced-in-human-gastric-cancer
#20
Zhengguang Wang, Fangyuan Xiong, Xiaoshan Wang, Yijun Qi, Haoyuan Yu, Yong Zhu, Huaqing Zhu
Retinoid-related orphan receptor α (RORα) is a nuclear receptor, which regulates inflammation and immune responses, lipid metabolism and circadian rhythm. Although RORα suppresses breast tumor invasion, it is unknown whether RORα is dysregulated in gastric cancer leading to cellular survival. Therefore, we hypothesize that RORα is dysfunctional in gastric carcinoma and this causes decreased apoptosis in gastric cancer cells. To test this hypothesis, we employed human gastric cancer tissues with different stages to determine RORα expression, as well as in vitro human gastric cancer cells to determine how RORα is reduced during apoptosis...
December 29, 2016: Oncotarget
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