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https://www.readbyqxmd.com/read/27894335/everolimus-and-exemestane-in-long-survival-hormone-receptor-positive-male-breast-cancer-case-report
#1
Z Ballatore, M Pistelli, N Battelli, A Pagliacci, M De Lisa, R Berardi, S Cascinu
BACKGROUND: Male breast cancer is a rare event, accounting for approximately 1% of all breast carcinomas. Although men with breast cancer had poorer survival when compared with women, data on prognosis principally derive from retrospective studies and from extrapolation of female breast cancer series. We reported the case of a very long survival patient. CASE PRESENTATION: A caucasian 42-year-old man underwent radical mastectomy with axillary dissection for breast cancer in 1993...
November 28, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27406875/endocrine-resistance-in-hormone-responsive-breast-cancer-mechanisms-and-therapeutic-strategies
#2
REVIEW
Conleth G Murphy, Maura N Dickler
The majority of breast cancers may be considered hormone responsive due to expression of hormone receptors (HR+). Although endocrine therapy is always considered for advanced HR+ breast cancer, the emergence of resistance is inevitable over time and is present from the start in a proportion of patients. In this review, we explore the mechanisms underlying de novo and acquired resistance to endocrine therapy. We comprehensively review newly approved and emerging therapies that have been developed to counteract specific mechanisms of resistance...
August 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27007055/addressing-the-elephant-in-the-room-therapeutic-resistance-in-non-small-cell-lung-cancer-with-epigenetic-therapies
#3
Corey A Carter, Karen Zeman, Regina M Day, Patrick Richard, Arnold Oronsky, Neil Oronsky, Michelle Lybeck, Jan Scicinski, Bryan Oronsky
Like Chinese boxes nesting inside each other, the classification of non-small cell lung cancer (NSCLC) is subdivided into smaller and smaller subtypes on the basis of histological and molecular attributes. The latter characterizes NSCLC by its molecular alterations and the identification of inhibitors that target these cancer-specific "driver" mutations. Despite the initial promise of precision-guided therapies to inhibit a finer and finer array of molecular subcategories, despite even the curative potential of immunotherapeutic checkpoint blockade, in particular, casualties still abound and true clinical success stories are few and far between; the ever-present, if sometimes unmentioned, "elephant in the room", is the acquisition of resistance, which, sooner or later, rears its ugly head to undermine treatment success and shorten survival...
March 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/26887513/-association-between-the-expression-of-igf1r-and-estrogen-receptor-and-efficacy-of-neoadjuvant-chemotherapy-in-beast-cancer-patients
#4
Lei Liu, Xiru Li, Jin Zhang
OBJECTIVE: To detect the expression of IGF1R and estrogen receptor, and to explore the relationship between their expression and the pathological complete response (pCR) rate of neoadjuvant chemotherapy (docetaxel plus epirubicin) in breast cancer patients. METHODS: We selected 139 women with breast cancer who underwent neoadjuvant chemotherapy (docetaxel plus epirubicin), and detected the expression of IGF1R and estrogen receptor in the samples taken before chemotherapy by Immunohistochemistry...
November 2015: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/26229121/prodding-the-beast-assessing-the-impact-of-treatment-induced-metastasis
#5
REVIEW
John M L Ebos
The arsenal of treatments for most cancers fit broadly into the categories of surgery, chemotherapy, radiation, and targeted therapy. All represent proven and successful strategies, yet each can trigger local (tumor) and systemic (host) processes that elicit unwanted, often opposing, influences on cancer growth. Under certain conditions, nearly all cancer treatments can facilitate metastatic spread, often in parallel (and sometimes in clear contrast) with tumor reducing benefits. The paradox of treatment-induced metastasis (TIM) is not new...
September 1, 2015: Cancer Research
https://www.readbyqxmd.com/read/26217587/melanoma-from-incurable-beast-to-a-curable-bet-the-success-of-immunotherapy
#6
REVIEW
Maria Libera Ascierto, Ignacio Melero, Paolo Antonio Ascierto
After Coley's observation in 1891 of tumor regression in a patient who developed a postoperative infection, the field of immunotherapy is finally reborn. Avoiding immune destruction is now considered a hallmark of cancer, and the immunotherapy arena has exploded with the recent advances demonstrating an improvement in survival and a durability of response in patients with different cancer types, which translates into improved overall survival benefit. Here, we provide an overview of the main immune-oncology treatment strategies that, either alone or in combination, are undergoing clinical development...
2015: Frontiers in Oncology
https://www.readbyqxmd.com/read/25461847/genetic-characterization-and-clinical-implications-of-human-papillomavirus-type-16-hpv16-variants-from-northeastern-argentina
#7
Inés Badano, Maria Elina Totaro, Andrés Carlos Alberto Culasso, Daiana Jimena Sanabria, Theodore G Schurr, Ileana Cristina Balette, Alejandro Roisman, Jorge Basiletti, María Alejandra Picconi, Rodolfo Héctor Campos, Domingo Javier Liotta
BACKGROUND: Human papillomavirus type 16 (HPV16) plays a central role in the development of cervical cancer. Worldwide studies indicate the existence of HPV16 variants that show different geographic distributions and oncogenic potential. OBJECTIVE: Our goal was to describe the genetic variation of HPV16 isolates identified in urban women with different grades of cervical lesions living in northeastern Argentina. STUDY DESIGN: We analyzed 116 HPV16-positive cervical samples (16 NLIM, 62 L-SIL, 16 H-SIL and 22 cervical cancer) from patients attending health centers in Misiones (Argentina) during 2006-13...
January 2015: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/25293892/my-encounters-with-bacteria-learning-about-communication-cooperation-and-choice
#8
Eshel Ben-Jacob
My journey into the physics of living systems began with the most fundamental organisms on Earth, bacteria, that three decades ago were perceived as solitary, primitive creatures of limited capabilities. A decade later this notion had faded away and bacteria came to be recognized as the smart beasts they are, engaging in intricate social life through a sophisticated chemical language. Acting jointly, these tiny organisms can sense the environment, process information, solve problems and make decisions so as to thrive in harsh environments...
2014: Physical Biology
https://www.readbyqxmd.com/read/24660968/lithocarpus-polystachyus-rehd-leaf-aqueous-extract-inhibits-human-breast-cancer-growth-in-vitro-and-in-vivo
#9
Caiyu Lin, Li Wang, Hong Wang, Shengtao Fang, Quanbo Zhang, Liuqi Yang, Huijie Guo, Ping Lin, Jie Zhang, Xiujie Wang
Lithocarpus polystachyus leaves have been used as tea beverage and folk medicine for healthy care in the Southwest of China. The purpose of this study is to investigate the anticancer activity of Lithocarpus polystachyus Rehd leaf aqueous extract (LPAE) and to explore the possible mechanism of its activity. Growth inhibition effects of LPAE breast cancer were tested in vitro and in vivo. The possible mechanism of its activity was analyzed with cell biological and molecular biological assays. After LPAE treatment, the proliferation and colony formation of cancer cells decreased; apoptotic cells increased; DNA fragmentations were evident; mRNA and protein expressions of PPARγ, Bax, and caspase-3 genes increased and expressions of cyclin D1 and Bcl-2 genes decreased; in vivo experiment, LPAE inhibited human beast cancer growth...
2014: Nutrition and Cancer
https://www.readbyqxmd.com/read/24550935/the-gene-regulatory-network-for-breast-cancer-integrated-regulatory-landscape-of-cancer-hallmarks
#10
Frank Emmert-Streib, Ricardo de Matos Simoes, Paul Mullan, Benjamin Haibe-Kains, Matthias Dehmer
In this study, we infer the breast cancer gene regulatory network from gene expression data. This network is obtained from the application of the BC3Net inference algorithm to a large-scale gene expression data set consisting of 351 patient samples. In order to elucidate the functional relevance of the inferred network, we are performing a Gene Ontology (GO) analysis for its structural components. Our analysis reveals that most significant GO-terms we find for the breast cancer network represent functional modules of biological processes that are described by known cancer hallmarks, including translation, immune response, cell cycle, organelle fission, mitosis, cell adhesion, RNA processing, RNA splicing and response to wounding...
2014: Frontiers in Genetics
https://www.readbyqxmd.com/read/24375252/the-co-expression-of-telomerase-and-alt-pathway-in-human-breast-cancer-tissues
#11
Bin Xu, Min Peng, Qibin Song
Recently, telomerase-targeted therapy was studied intensively; however, many studies have verified the existence of alternative lengthening mechanisms of telomeres in vitro. In the present work, we explored the expression characteristic of the two kinds of telomere-prolonging mechanisms in the breast cancer tissues per se. Furthermore, we studied the relationship between Her-2 expression and ALT pathway. Ninety samples of breast cancer tissues were examined in this research. RT-PCR was used for the detection of the expression of human telomerase reverse transcriptase (hTERT); IHC was used for the detection of the expression of promyelocytic leukemia body (PML) bodies; the co-expression of PML bodies and hTERT was detected using the QDs-based immunofluorescence...
May 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/24139069/synchronous-and-metachronous-metastatic-breast-cancer-two-incarnations-of-the-same-beast
#12
EDITORIAL
Elżbieta Senkus
No abstract text is available yet for this article.
February 2014: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/23665741/future-prospects-who-is-the-patient-who-still-dies-of-prostate-cancer-following-local-treatment-of-high-risk-prostate-cancer-can-we-prolong-their-lives-using-modern-treatment-approaches
#13
Benjamin E Ayres, Prasanna Sooriakumaran
PURPOSE OF REVIEW: Prostate cancer remains the commonest nondermatological cause of cancer in Western men and the second leading cause of cancer death in these men. While low and intermediate-risk prostate cancers make up the vast bulk of prostate cancer diagnoses, it is high-risk prostate cancer that is a much larger killer. Management paradigms for such disease are changing and thus we review the current state of play with the management of these cancers and what the future might hold...
July 2013: Current Opinion in Urology
https://www.readbyqxmd.com/read/23366466/localization-and-detection-of-breast-cancer-tumors-with-digital-image-elasto-tomography
#14
Elijah E W Van Houten, Helen Kershaw, Thomas Lotz, J Geoffrey Chase
Digital Image Elasto-Tomography (DIET) is a novel elastic contrast based breast imaging method using time-harmonic motion data obtained from a calibrated array of high resolution digital cameras scanning the tissue surface. The method is currently undergoing initial clinical testing and preliminary results in cases of malignant breast tumors are now available. The method has proved capable of detecting and localizing the stiff lesions within the heterogeneous tissue structure of the beast through the use of an evolution based optimization algorithm implemented in linear finite elements...
2012: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/23039620/second-cancer-incidence-risk-estimates-using-beir-vii-models-for-standard-and-complex-external-beam-radiotherapy-for-early-breast-cancer
#15
E M Donovan, H James, M Bonora, J R Yarnold, P M Evans
PURPOSE: To compare organ specific cancer incidence risks for standard and complex external beam radiotherapy (including cone beam CT verification) following breast conservation surgery for early breast cancer. METHOD: Doses from breast radiotherapy and kilovoltage cone beam CT (CBCT) exposures were obtained from thermoluminescent dosimeter measurements in an anthropomorphic phantom in which the positions of radiosensitive organs were delineated. Five treatment deliveries were investigated: (i) conventional tangential field whole breast radiotherapy (WBRT), (ii) noncoplanar conformal delivery applicable to accelerated partial beast irradiation (APBI), (iii) two-volume simultaneous integrated boost (SIB) treatment, (iv) forward planned three-volume SIB, and (v) inverse-planned three volume SIB...
October 2012: Medical Physics
https://www.readbyqxmd.com/read/22812710/spatial-and-temporal-measurements-of-temperature-and-cell-viability-in-response-to-nanoparticle-mediated-photothermal-therapy
#16
Jon R Whitney, Amanda Rodgers, Erica Harvie, William F Carswell, Suzy Torti, Alex A Puretzky, Christopher M Rouleau, David B Geohegan, Christopher G Rylander, Marissa N Rylander
AIM: Nanoparticle-enhanced photothermal therapy is a promising alternative to tumor resection. However, quantitative measurements of cellular response to these treatments are limited. This article introduces a Bimodal Enhanced Analysis of Spatiotemporal Temperature (BEAST) algorithm to rapidly determine the viability of cancer cells in vitro following photothermal therapy alone or in combination with nanoparticles. MATERIALS & METHODS: To illustrate the capability of the BEAST viability algorithm, single wall carbon nanohorns were added to renal cancer (RENCA) cells in vitro and time-dependent spatial temperature maps measured with an infrared camera during laser therapy were correlated with post-treatment cell viability distribution maps obtained by cell-staining fluorescent microscopy...
November 2012: Nanomedicine
https://www.readbyqxmd.com/read/22093628/-expression-of-indoleamine-2-3-dioxygenase-and-its-correlation-with-prognosis-in-breast-cancer-patients
#17
Jun-tian Liu, Li-juan Wei, Jin-pu Yu, Hui Li, Run-mei Li, Feng-lin Zang, Jing-yan Sun, Xiu-bao Ren
OBJECTIVE: To investigate the expression of indoleamine 2, 3-dioxygenase (IDO) in breast cancer and its correlation with clinicopathologic factors and prognosis. METHODS: The expression of IDO, CD31, CD105 proteins in 40 specimens of breast cancer were assessed by immunohistochemistry. RESULTS: The overexpression rate of IDO in breast cancer was 67.5% (27/40), and expression of IDO was closely associated with clinical stage and lymph nodes metastasis...
July 2011: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/21779457/myc-the-beauty-and-the-beast
#18
Amanda R Wasylishen, Linda Z Penn
The iconic history of the Myc oncoprotein encompasses 3 decades of intense scientific discovery. There is no question that Myc has been a pioneer, advancing insight into the molecular basis of cancer as well as functioning as a critical control center for several diverse biological processes and regulatory mechanisms. This narrative chronicles the journey and milestones that have defined the understanding of Myc, and it provides an opportunity to consider future directions in this challenging yet rewarding field...
June 2010: Genes & Cancer
https://www.readbyqxmd.com/read/21423094/down-regulation-of-abcc11-protein-mrp8-in-human-breast-cancer
#19
N Sosonkina, M Nakashima, T Ohta, N Niikawa, D Starenki
AIM: To investigate the expression of ABCC11 (MRP8) protein in normal breast tissue, and examine the difference in ABCC11 mRNA and protein expression between normal breast and breast cancer tissues taking into account ABCC11 genotype (a functional SNP, rs17822931) and estrogen receptor (ER) status. METHODS: Sections of paraffin-embedded normal and malignant tissues from 10 patients with invasive ductal carcinoma were used for immunohistochemical analysis. DNA and RNA were extracted from the same sections and used for genotyping and ABCC11 transcript expression measurement by quantitative RT-PCR...
March 2011: Experimental Oncology
https://www.readbyqxmd.com/read/21322269/-extraperitoneal-rectal-cancer-chemo-radiotherapy-treatments
#20
Enrico Cortesi, Alessandro Tuzi, Daniela Musio
PURPOSE: The determination of the best therapeutic approach in extraperitoneal rectal cancer patients is very complex both in the neoadjuvant/adjuvant and the metastatic setting. We tried to identify and summarize the current methods of diagnosis, staging and treatment from a multidisciplinary approach. METHODS: Five sections can be indentified: diagnosis and staging; neoadjuvant treatment; adjuvant treatment; liver metastases treatment and local recurrence therapy Data were collected from international guidelines (NCCN) and MEDLINE search...
July 2010: Annali Italiani di Chirurgia
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