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https://www.readbyqxmd.com/read/29915281/platelet-derived-growth-factor-receptor-%C3%AE-and-%C3%AE-promote-cancer-stem-cell-phenotypes-in-sarcomas
#1
Kevin K Chang, Changhwan Yoon, Brendan C Yi, William D Tap, M Celeste Simon, Sam S Yoon
Sarcomas are malignant tumors derived from mesenchymal tissues and may harbor a subset of cells with cancer stem-like cell (CSC) properties. Platelet-derived growth factor receptors α and β (PDGFR-α/β) play an important role in the maintenance of mesenchymal stem cells. Here we examine the role of PDGFR-α/β in sarcoma CSCs. PDGFR-α/β activity and the effects of PDGFR-α/β inhibition were examined in 3 human sarcoma cell lines using in vitro assays and mouse xenograft models. In all three cell lines, PDGFR-α/β activity was significantly higher in cells grown as spheroids (to enrich for CSCs) and in cells sorted for CD133 expression (a marker of sarcoma CSCs)...
June 19, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29914782/a-randomized-trial-comparing-surgeon-administered-intraoperative-transversus-abdominis-plane-block-with-anesthesiologist-administered-transcutaneous-block
#2
D M Narasimhulu, L Scharfman, H Minkoff, B George, P Homel, K Tyagaraj
BACKGROUND: Injection of local anesthetic into the transversus abdominis plane (TAP block) decreases systemic morphine requirements after abdominal surgery. We compared intraoperative surgeon-administered TAP block (surgical TAP) to anesthesiologist-administered transcutaneous ultrasound-guided TAP block (conventional TAP) for post-cesarean analgesia. We hypothesized that surgical TAP blocks would take less time to perform than conventional TAP blocks. METHODS: We performed a randomized trial, recruiting 41 women undergoing cesarean delivery under neuraxial anesthesia, assigning them to either surgical TAP block (n=20) or conventional TAP block (n=21)...
April 27, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29910495/effect-of-addition-of-dexamethasone-to-ropivacaine-on-post-operative-analgesia-in-ultrasonography-guided-transversus-abdominis-plane-block-for-inguinal-hernia-repair-a-prospective-double-blind-randomised-controlled-trial
#3
Uma Datt Sharma, Prateek, Himani Tak
Background and Aims: Ultrasonography (USG)-guided transversus abdominis plane (TAP) block is an abdominal field block with high efficacy. This study was undertaken with the aim of determining the effect of the addition of dexamethasone to 0.5% ropivacaine on post-operative analgesia in USG-guided TAP block for inguinal hernia repair. Methods: A double-blind randomised control study was conducted on sixty patients posted for inguinal hernia repair with the American Society of Anesthesiologists physical Status I or II, who were allocated two groups of 30 each...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29902215/clinical-analgesic-efficacy-of-dexamethasone-as-a-local-anesthetic-adjuvant-for-transversus-abdominis-plane-tap-block-a-meta-analysis
#4
Qi Chen, Ran An, Ju Zhou, Bin Yang
BACKGROUND: Perineural dexamethasone has been shown to prolong the duration of local anesthetic (LA) effect in regional anesthesia; however, the use of perineural dexamethasone as an adjuvant to to the transversus abdominis plane (TAP) block remains controversial. This meta-analysis sought to assess the efficacy of dexamethasone in prolonging the TAP block and enhancing recovery after abdominal surgery. METHODS: We identified and analyzed 9 RCTs published on or before September 30, 2017, regardless of the original language, after searching the following 6 bibliographic databases: PubMed, EMBASE, Medline, Springer, Ovid, and the Cochrane Library...
2018: PloS One
https://www.readbyqxmd.com/read/29898021/dental-caries-in-schoolchildren-influence-of-inattention-hyperactivity-and-executive-functions
#5
Isabella Mota-Veloso, Maria Letícia Ramos-Jorge, Marcio Alexandre Homem, Isabela Almeida Pordeus, Saul Martins Paiva, Fernanda Oliveira-Ferreira
Attention-deficit/hyperactivity disorder (ADHD) is characterized by inappropriate levels of hyperactivity, impulsivity, and/or inattention. Individuals with ADHD may present limitations with regard to executive functions and performing activities that involve planning and/or attention/concentration. The aim of the study was to investigate the association between dental caries and signs of ADHD in a representative sample of schoolchildren. A representative sample of 851 schoolchildren aged seven to 12 years was randomly selected from public and private schools...
June 7, 2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29879000/-transversus-abdominis-plane-blocks-in-microsurgical-breast-reconstruction-analysis-of-pain-narcotic-consumption-length-of-stay-and-cost
#6
Ara A Salibian, Jordan D Frey, Vishal D Thanik, Nolan S Karp, Mihye Choi
BACKGROUND: Transversus abdominis plane (TAP) blocks are increasingly being utilized in microvascular breast reconstruction. The implications of TAP blocks on specific reconstructive, patient and institutional outcomes remain to be fully elucidated. METHODS: Patients undergoing abdominally-based microvascular breast reconstruction from 2015-2017 were reviewed. Length of stay, complications, narcotic consumption, donor-site pain and hospital expenses were compared between patients that did and those that did not receive TAP blocks with liposomal bupivacaine...
June 2, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29869078/efficacy-of-ultrasound-guided-transversus-abdominis-plane-tap-block-for-postoperative-analgesia-in-laparoscopic-gastric-sleeve-resection-a-randomized-single-blinded-case-control-study
#7
Tarun Mittal, Ashish Dey, Rahul Siddhartha, Abhilash Nali, Bimla Sharma, Vinod Malik
BACKGROUND: Pain following bariatric surgery can be quite troublesome and prolongs recovery. Transversus abdominis plane (TAP) block is a new regional anesthetic technique to reduce postoperative pain and is an important part of current analgesic regimen for many abdominal surgeries. The primary objective of our study was to assess the efficacy of the TAP block in controlling postoperative pain in laparoscopic sleeve gastrectomy. Secondary outcomes assessed in this study were postoperative nausea and vomiting (PONV), time to ambulate, readiness for discharge, and whether it leads to improved patient satisfaction...
June 4, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29868443/dynamic-causal-modeling-revealed-dysfunctional-effective-connectivity-in-both-the-cortico-basal-ganglia-and-the-cerebello-cortical-motor-network-in-writers-cramp
#8
Inken Rothkirch, Oliver Granert, Arne Knutzen, Stephan Wolff, Felix Gövert, Anya Pedersen, Kirsten E Zeuner, Karsten Witt
Writer's cramp (WC) is a focal task-specific dystonia characterized by sustained or intermittent muscle contractions while writing, particularly with the dominant hand. Since structural lesions rarely cause WC, it has been assumed that the disease might be caused by a functional maladaptation within the sensory-motor system. Therefore, our objective was to examine the differences between patients suffering from WC and a healthy control (HC) group with regard to the effective connectivity that describes causal influences one brain region exerts over another within the motor network...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29859296/disentangling-representations-of-shape-and-action-components-in-the-tool-network
#9
Xiaoying Wang, Tonghe Zhuang, Jiasi Shen, Yanchao Bi
Shape and how they should be used are two key components of our knowledge about tools. Viewing tools preferentially activated a frontoparietal and occipitotemporal network, with dorsal regions implicated in computation of tool-related actions and ventral areas in shape representation. As shape and manners of manipulation are highly correlated for daily tools, whether they are independently represented in different regions remains inconclusive. In the current study, we collected fMRI data when participants viewed blocks of pictures of four daily tools (i...
May 30, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29848599/ultrasound-guided-oblique-sub-costal-transversus-abdominis-plane-block-as-the-principal-anesthesia-technique-in-peritoneal-dialysis-catheter-implantation-and-plasma-ropivacaine-concentration-evaluation-in-esrd-patients-a-prospective-randomized-double-blinded
#10
Zi Li, Xiao Hong Tang, Qi Li, Wen-Juan Zhang, Tian Tao, Tao Zhu
BACKGROUND: The ultrasound-guided transversus abdominis plane (TAP) block is generally used for analgesia but not for anesthesia. A TAP block has a partial analgesic effect on the parietal peritoneum in abdominal surgeries. We hypothesized that an ultrasound-guided oblique subcostal TAP block, used as the principal anesthesia technique, could provide a better anesthetic effect on peritoneum stimulation in peritoneal dialysis catheter (PDC) implantation in end-stage renal diseases (ESRD) patients than local anesthetic infiltration (LAI)...
May 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29846391/do-different-strains-of-e-faecalis-have-the-same-behavior-towards-intracanal-medications-in-in-vitro-research
#11
Rafaela Fernandes Zancan, Lyz Cristina Furquim Canali, Talita Tartari, Flaviana Bombarda de Andrade, Rodrigo Ricci Vivan, Marco Antonio Hungaro Duarte
The aim of this study was to evaluate the antimicrobial action of different endodontic pastes against Enterococcus faecalis ATCC 29212, isolated from the urinary tract, and compare the action with E. faecalis ATCC 4083, isolated from the root canal. For this purpose, dentin blocks were infected for 21 days with both bacteria at different time-intervals to ensure there would be no cross contamination. After this period, blocks were immersed in the test medications for 7 days, according to the following groups: CH/S, CH/P, CH/CMCP, CH/CHX, CH/DAP and TAP...
May 24, 2018: Brazilian Oral Research
https://www.readbyqxmd.com/read/29759061/role-of-ultrasound-guided-transversus-abdominis-plane-block-as-a-component-of-multimodal-analgesic-regimen-for-lower-segment-caesarean-section-a-randomized-double-blind-clinical-study
#12
Ashok Jadon, Priyanka Jain, Swastika Chakraborty, Mayur Motaka, Sudhansu Sekhar Parida, Neelam Sinha, Amit Agrawal, Asit Kumar Pati
BACKGROUND: While opioids are the mainstay for post-operative analgesia after lower segment caesarean section, they are associated with various untoward effects. Ultrasound guided transversus abdominis plane (TAP) block has been postulated to provide effective analgesia for caesarean section. We evaluated the analgesic efficacy of this block for post caesarean analgesia in a randomised controlled trial. METHODS: One hundred thirty-nine mothers undergoing caesarean delivery were randomised to receive TAP block with either 20 ml 0...
May 14, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29750760/prospective-randomized-controlled-comparison-of-local-anesthetic-infusion-pump-versus-depofoam-bupivacaine-for-pain-management-after-unilateral-delayed-deep-inferior-epigastric-perforator-free-flap-reconstruction
#13
James Gatherwright, Rebecca Knackstedt, Amir Ghaznavi, Steven Bernard, Graham Schwarz, Andrea Moreira, Raffi Gurunluoglu, Risal Djohan
BACKGROUND: Effective postsurgical analgesia is a critical aspect of patient recovery. The goal of this prospective, randomized, controlled, blinded study was to examine the effect that liposomal bupivacaine delivered via a transversus abdominis plane (TAP) block has on pain control in women undergoing unilateral deep inferior epigastic perforator reconstruction. METHODS: IRB approval was granted for this prospective study. Patients were eligible if they were undergoing unilateral, delayed DIEP reconstruction...
March 15, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29738057/-a-comparison-of-transversus-abdominis-plane-block-guided-with-ultrasonography-and-local-anesthetic-infiltration-in-laparoscopic-cholecystectomy-operations
#14
Burhan Dost, Gülbin Yalçın Sezen, Abdulkadir İskender, Onur Özlü
OBJECTIVES: The aim of this study was to compare a transversus abdominis plane (TAP) block guided with ultrasound (USG) and local anesthetic infiltration (LAI) in terms of the intraoperative and postoperative analgesia efficiency, intraoperative opioid need, and side effects in cases of laparoscopic cholecystectomy. METHODS: A total of 75 patients classified as American Society of Anesthesiologists class I or II were included in this randomized, controlled, prospective study and divided into 3 groups...
April 2018: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29723644/transversus-abdominis-plane-block-for-post-hysterectomy-pain-a-systematic-review-and-meta-analysis
#15
REVIEW
Vanessa Bacal, Urvi Rana, Daniel I McIsaac, Innie Chen
The objective of this study was to address the efficacy of transversus abdominis plane (TAP) blocks in pain management among women who undergo elective hysterectomy for benign pathology in both open and minimally invasive surgeries. We performed a systematic review by searching for bibliographic citations from Medline, Embase and Cochrane Library. MeSH headings for TAP blocks and hysterectomy were combined and restricted to the English language. We included RCTs comparing TAP blocks to placebo or no block in patients who underwent elective hysterectomy...
April 30, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29723578/conventional-epidural-vs-transversus-abdominis-plane-block-with-liposomal-bupivacaine-a-randomized-trial-in-colorectal-surgery
#16
Matthew Torgeson, Joel Kileny, Christopher Pfeifer, Lawrence Narkiewicz, Shawn Obi
BACKGROUND: Colorectal surgery is a focus of enhanced recovery protocols (ERP). The utility of Transversus Abdominis Plane block (TAP) for abdominal surgery has demonstrated effectiveness in ERP, however no direct comparison of epidural versus TAP for non-analgesic clinical factors have been published to date. The primary aim of this study was to compare epidural to TAP for length of stay (LOS) in colorectal surgery. STUDY DESIGN: Patients undergoing open and laparoscopic colorectal surgery were prospectively randomized into epidural (n=39) or TAP (n=44) groups preoperatively...
April 30, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29721629/direct-visualization-transversus-abdominis-plane-blocks-offer-superior-pain-control-compared-to-ultrasound-guided-blocks-following-open-posterior-component-separation-hernia-repairs
#17
J A Doble, J S Winder, S R Witte, E M Pauli
PURPOSE: Transversus abdominis plane (TAP) blockade with long-acting anesthetic can be used during open ventral hernia repair (VHR) with posterior component separation (PCS). TAP block can be performed under ultrasound guidance (US-TAP) or under direct visualization (DV-TAP). We hypothesized that US-TAP and DV-TAP provide equivalent postoperative analgesia following open VHR. METHODS: A retrospective review of patients undergoing open VHR with PCS who received TAP blocks with 266 mg of liposomal bupivacaine was performed...
May 2, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29720755/a-comparative-study-to-evaluate-ultrasound-guided-transversus-abdominis-plane-block-versus-ilioinguinal-iliohypogastric-nerve-block-for-post-operative-analgesia-in-adult-patients-undergoing-inguinal-hernia-repair
#18
Kirti Kamal, Parul Jain, Teena Bansal, Geeta Ahlawat
Background and Aims: Both transversus abdominis plane (TAP) block and combined ilioinguinal-iliohypogastric (IIN/IHN) blocks are used routinely under ultrasound (USG) guidance for postoperative pain relief in patients undergoing inguinal hernia surgery. This study compares USG guided TAP Vs IIN/IHN block for post-operative analgesic efficacy in adults undergoing inguinal hernia surgery. Methods: Sixty adults aged 18 to 60 with American Society of Anesthesiologsts' grade I or II were included...
April 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29662806/early-clinical-outcomes-of-tricuspid-valve-repair-with-a-tri-ad-annuloplasty-ring-in-comparison-with-the-outcomes-using-an-mc-3-ring
#19
Woohyun Jung, Jae Woong Choi, Ho Young Hwang, Kyung Hwan Kim
Background: We evaluated the early clinical outcomes of tricuspid valve annuloplasty (TAP) with the Tri-Ad annuloplasty ring for functional tricuspid regurgitation (TR). Methods: From January 2015 to March 2017, 36 patients underwent TAP with a Tri-Ad ring for functional TR. To evaluate the early clinical outcomes of TAP with the Tri-Ad ring, we conducted a propensity score-matched analysis comparing the Tri-Ad and MC3 tricuspid annuloplasty rings (n=34 in each group)...
April 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29662278/comparison-of-efficacy-of-bupivacaine-with-dexmedetomidine-versus-bupivacaine-alone-for-transversus-abdominis-plane-block-for-post-operative-analgesia-in-patients-undergoing-elective-caesarean-section
#20
A Ramya Parameswari, Prabha Udayakumar
Background: Increasing rate of Caesarean sections and inadequate pain relief following Caesarean section is seen in almost all parts of the world. Transversus abdominis plane block is gaining popularity as a part of multimodal analgesia for post-operative pain relief following abdominal surgeries. Aim: To compare bupivacaine and bupivacaine with dexmedetomidine in transversus abdominis plane block for pain relief after Caesarean section. Method: American Society of Anaesthesiologists I and II parturients with no comorbidities admitted for elective Caesarean section were included in the study...
April 2018: Journal of Obstetrics and Gynaecology of India
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