Leïla Dos Santos, Francesco Carbone, Emeline Pacreau, Sekou Diarra, Marine Luka, Natascha Pigat, Manon Baures, Emilie Navarro, Julien Anract, Nicolas Barry Delongchamps, Nicolas Cagnard, Frédéric Bost, Ivan Nemazanyy, Olivier Petitjean, Ahmed Hamaï, Mickaël Menager, Stefano Palea, Jacques-Emmanuel Guidotti, Vincent Goffin
Benign prostate hyperplasia (BPH) is caused by the non-malignant enlargement of the transition zone of the prostate gland, leading to lower urinary tract symptoms (LUTS). While current medical treatments are unsatisfactory in many patients, the limited understanding of the mechanisms driving disease progression prevents the development of alternative therapeutic strategies. The probasin-prolactin (Pb-PRL) transgenic mouse recapitulates many histopathological features of human BPH. We here show that these alterations parallel urodynamic disturbance reminiscent of LUTS...
October 10, 2023: American Journal of Pathology