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anthraquinone

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https://www.readbyqxmd.com/read/28088261/parquetina-nigrescens-leaves-chemical-profile-and-influence-on-the-physical-and-biochemical-indices-of-sexual-activity-of-male-wistar-rats
#1
Omowumi Titilola Kayode, Musa Toyin Yakubu
OBJECTIVE: The leaves of Parquetina nigrescens have been claimed in folk medicine to be useful for managing sexual dysfunction, but there is inadequate scientific evidence for this claim. This investigation was conducted to assess the effects of aqueous leaf extract of Parquetina nigrescens (AEPN) in rats induced with sexual dysfunction. METHODS: Male rats were allocated into various groups after being induced into sexual dysfunction with paroxetine hydrochloride...
January 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28056963/antimalarial-activity-of-syzygium-guineense-during-early-and-established-plasmodium-infection-in-rodent-models
#2
Solomon Asmamaw Tadesse, Zewdu Birhanu Wubneh
BACKGROUND: In Ethiopia, the leaves of Syzygium guineense have been found useful for the prevention and cure of malaria, and demonstrated antiplasmodial activity in vitro. Nevertheless, no scientific study has been conducted to confirm its antimalarial activity in vivo. Therefore, the objective of the study was to evaluate the antimalarial effect of Syzygium guineense leaf extract in mice. METHODS: Inoculation of the study mice was carried out by using the malaria parasite, Plasmodium berghei...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28056932/in-vivo-antimalarial-activity-of-crude-extracts-and-solvent-fractions-of-leaves-of-strychnos-mitis-in-plasmodium-berghei-infected-mice
#3
Selamawit Fentahun, Eyasu Makonnen, Tesfaye Awas, Mirutse Giday
BACKGROUND: Malaria is a major public health problem in the world which is responsible for death of millions particularly in sub-Saharan Africa. Today, the control of malaria has become gradually more complex due to the spread of drug-resistant parasites. Medicinal plants are the unquestionable source of effective antimalarials. The present study aimed to evaluate antiplasmodial activity and acute toxicity of the plant Strychnos mitis in Plasmodium berghei infected mice. METHODS: Standard procedures were employed to investigate acute toxicity and 4-day suppressive effect of crude aqueous and hydro-methanolic extracts of the leaves of Strychnos mitis against P...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28045219/proton-coupled-electron-transfer-processes-in-ultrafast-time-domain-evidence-for-effects-of-h-bond-stabilization-on-photoinduced-electron-transfer
#4
Hirendra Nath Ghosh, Ananta Dey, Jayanta Dana, Sunil Auta, Partha Maity, Amitava Das
Proton coupled electron transfer (PCET) reaction has been investigated for a newly synthesized imidazole-anthraquinone bio mimetic model having a photoactive Ru(II)-polypyridyl moiety that is covalently coupled to the imidazole fragment. Intramolecular hydrogen bonding interaction between imidazole and anthraquinone moieties favoured the PCET process and this could be correlated to an appreciable positive shift of the one-electron reduction potential of the coordinated anthraquinone moiety functionalized with imidazole fragment...
January 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28035984/promising-inhibitory-effects-of-anthraquinones-naphthopyrone-and-naphthalene-glycosides-from-cassia-obtusifolia-on-%C3%AE-glucosidase-and-human-protein-tyrosine-phosphatases-1b
#5
Hyun Ah Jung, Md Yousof Ali, Jae Sue Choi
The present work aims to evaluate the anti-diabetic potentials of 16 anthraquinones, two naphthopyrone glycosides, and one naphthalene glycoside from Cassia obtusifolia via inhibition against the protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase. Among them, anthraquinones emodin and alaternin exhibited the highest inhibitory activities on PTP1B and α-glucosidase, respectively. Moreover, we examined the effects of alaternin and emodin on stimulation of glucose uptake by insulin-resistant human HepG2 cells...
December 27, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28034505/high-performance-thin-layer-chromatography-mass-spectrometry-of-japanese-knotweed-flavan-3-ols-and-proanthocyanidins-on-silica-gel-plates
#6
Vesna Glavnik, Irena Vovk, Alen Albreht
On-line elution based TLC-MS is now a well-established technique, but the quality of the data obtained can sometimes be hampered by a severe spectral background or by strong ion suppression, especially when silica gel plates are used in combination with an acidic modifier in the developing solvent. We solved this issue simply and efficiently using two pre-developments of the plates, firstly with methanol-formic acid (10:1, v/v) and secondly with acetonitrile-methanol (2:1, v/v). This solution resulted in significant improvement in the sensitivity of HPTLC-MS methods...
December 21, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28029239/solid-state-nmr-analysis-reveals-a-possible-calcium-binding-site-of-pradimicin-a
#7
Takashi Doi, Yu Nakagawa, Kiyonori Takegoshi
Pradimicin A (PRM-A) is a unique natural product that recognizes D-mannopyranoside (Man) in the presence of Ca(2+) ion. Although Man binding geometry of PRM-A has been largely understood, the molecular basis of Man recognition has yet to be established due to lack of the information regarding Ca(2+) binding geometry. In this work, to allocate the Ca(2+) binding site of PRM-A, we performed solid-state NMR experiment using (111)Cd(2+) as a surrogate probe for Ca(2+). Evaluation of (13)C-(111)Cd distances in the [PRM-A/(111)Cd(2+)] complexes by rotational-echo double resonance (REDOR) and (111)Cd frequency selective REDOR (FSR) revealed that PRM-A binds (111)Cd(2+) at the anthraquinone moiety, which contradicts the previous hypothesis of the alanine moiety being the Ca(2+) and Cd(2+) binding sites of PRM-A...
December 28, 2016: Biochemistry
https://www.readbyqxmd.com/read/28025453/preparation-of-a-ammonia-treated-lac-dye-and-structure-elucidation-of-its-main-component
#8
Yuzo Nishizaki, Kyoko Ishizuki, Hiroshi Akiyama, Atsuko Tada, Naoki Sugimoto, Kyoko Sato
Lac dye and cochineal extract contain laccaic acids and carminic acid as the main pigments, respectively. Both laccaic acids and carminic acid are anthraquinone derivatives. 4-Aminocarminic acid (acid-stable carmine), an illegal colorant, has been detected in several processed foods. 4-Aminocarminic acid is obtained by heating cochineal extract (carminic acid) in ammonia solution. We attempted to prepare ammonia-treated lac dye and to identify the structures of the main pigment components. Ammonia-treated lac dye showed acid stability similar to that of 4-aminocarminic acid...
2016: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28024230/in-silico-study-of-porphyrin-anthraquinone-hybrids-as-cdk2-inhibitor
#9
Muhammad Arba, Sunandar Ihsan, La Ode Ahmad Nur Ramadhan, Daryono Hadi Tjahjono
Cyclin-Dependent Kinases (CDKs) are known to play crucial roles in controlling cell cycle progression of eukaryotic cell and inhibition of their activity has long been considered as potential strategy in anti-cancer drug research. In the present work, a series of porphyrin-anthraquinone hybrids bearing meso-substituents, i.e. either pyridine or pyrazole rings were designed and computationally evaluated for their Cyclin Dependent Kinase-2 (CDK2) inhibitory activity using molecular docking, molecular dynamics simulation, and binding free energy calculation...
December 19, 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28010840/electrochemical-paper-based-peptide-nucleic-acid-biosensor-for-detecting-human-papillomavirus
#10
Prinjaporn Teengam, Weena Siangproh, Adisorn Tuantranont, Charles S Henry, Tirayut Vilaivan, Orawon Chailapakul
A novel paper-based electrochemical biosensor was developed using an anthraquinone-labeled pyrrolidinyl peptide nucleic acid (acpcPNA) probe (AQ-PNA) and graphene-polyaniline (G-PANI) modified electrode to detect human papillomavirus (HPV). An inkjet printing technique was employed to prepare the paper-based G-PANI-modified working electrode. The AQ-PNA probe baring a negatively charged amino acid at the N-terminus was immobilized onto the electrode surface through electrostatic attraction. Electrochemical impedance spectroscopy (EIS) was used to verify the AQ-PNA immobilization...
February 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28008317/chrysophanic-acid-suppresses-adipogenesis-and-induces-thermogenesis-by-activating-amp-activated-protein-kinase-alpha-in-vivo-and-in-vitro
#11
Hara Lim, Jinbong Park, Hye-Lin Kim, JongWook Kang, Mi-Young Jeong, Dong-Hyun Youn, Yunu Jung, Yong-Il Kim, Hyun-Ju Kim, Kwang Seok Ahn, Su-Jin Kim, Seong-Kyu Choe, Seung-Heon Hong, Jae-Young Um
Chrysophanic acid (CA) is a member of the anthraquinone family abundant in rhubarb, a widely used herb for obesity treatment in Traditional Korean Medicine. Though several studies have indicated numerous features of CA, no study has yet reported the effect of CA on obesity. In this study, we tried to identify the anti-obesity effects of CA. By using 3T3-L1 adipocytes and primary cultured brown adipocytes as in vitro models, high-fat diet (HFD)-induced obese mice, and zebrafish as in vivo models, we determined the anti-obesity effects of CA...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28006914/antioxidant-flavonols-and-phenolic-compounds-from-atraphaxis-frutescens-and-their-inhibitory-activities-against-insect-phenoloxidase-and-mushroom-tyrosinase
#12
Batsukh Odonbayar, Toshihiro Murata, Javzan Batkhuu, Kosho Yasunaga, Rina Goto, Kenroh Sasaki
Chemical investigation of the aerial parts of Atraphaxis frutescens resulted in the isolation of five 7-methoxyflavonols with pyrogallol B-ring moieties (1-5), a fisetinidol glucoside (13), and a benzyl glycoside (18), together with 26 known compounds including flavonoids, phenylpropanoid amides, anthraquinone glycosides, lignans, and a benzyl derivative. The principal chemical structural feature of the isolated compounds was either a pyrogallol or catechol B-ring moiety, and they showed potent 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities...
December 23, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/28004366/microbial-synthesis-of-bimetallic-pdpt-nanoparticles-for-catalytic-reduction-of-4-nitrophenol
#13
Ya Tuo, Guangfei Liu, Bin Dong, Huali Yu, Jiti Zhou, Jing Wang, Ruofei Jin
Bimetallic nanoparticles are generally believed to have improved catalytic activity and stability due to geometric and electronic changes. In this work, biogenic-Pd (bio-Pd), biogenic-Pt (bio-Pt), and biogenic-PdPt (bio-PdPt) nanoparticles were synthesized by Shewanella oneidensis MR-1 in the absence or presence of quinone. Compared with direct microbial reduction process, the addition of anthraquinone-2,6-disulfonate (AQDS) could promote the reduction efficiency of Pd(II) or/and Pt(IV) and result in decrease of particles size...
December 21, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28004097/electro-catalytic-oxidation-of-catechol-at-poly-1-amino-9-10-anthraquinone-sds-composite-film
#14
Hossein Nikoofard, Malihe Solbi
An electro-chemically active composite film containing the environmentally friendly surfactant sodium dodecyl sulfate (SDS) and poly(1-amino-9,10-anthraquinone) (PAAQ) is used as an electron transfer mediator in the electro-chemical oxidation of catechol. Compared with the bare platinum (Pt) electrode, the Pt/PAAQ-SDS modified electrode remarkably lowers the anodic peak potential of catechol, and increases the peak currents. The results obtained indicate that the activation energy for the electro-chemical oxidation of catechol at the polymer film is low (7...
December 2016: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/28000546/ortho-methylarylamines-as-time-dependent-inhibitors-of-cytochrome-p450-1a1-enzyme
#15
Jayalakshmi Sridhar, Jiawang Liu, Rajesh Komati, Richard Schroeder, Quan Jiang, Phan Tram, Kevin Riley, Maryam Foroozesh
Members of the cytochrome P450 1A family metabolize many procarcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Inactivation of these enzymes is prerequisite for cancer prevention and treatment in certain cases. Mechanism-based inhibition (time and co-factor dependent) is an effective method for the inactivation of these enzymes. Our recent study on emodin analogs revealed an anthraquinone with ortho-methylarylamine moiety that exhibited time-dependent inhibition of P450 enzymes 1A1 and 1A2...
December 20, 2016: Drug Metabolism Letters
https://www.readbyqxmd.com/read/27999402/a-review-of-the-botany-phytochemistry-pharmacology-and-toxicology-of-rubiae-radix-et-rhizoma
#16
REVIEW
Mingqiu Shan, Sheng Yu, Hui Yan, Peidong Chen, Li Zhang, Anwei Ding
Rubia cordifolia Linn (Rubiaceae) is a climbing perennial herbal plant, which is widely distributed in China and India. Its root and rhizome, Rubiae Radix et Rhizoma (called Qiancao in China and Indian madder in India), is a well known phytomedicine used for hematemesis, epistaxis, flooding, spotting, traumatic bleeding, amenorrhea caused by obstruction, joint impediment pain, swelling and pain caused by injuries from falls. In addition, it is a kind of pigment utilized as a food additive and a dye for wool or fiber...
December 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27998305/cytotoxicity-of-plumbagin-rapanone-and-12-other-naturally-occurring-quinones-from-kenyan-flora-towards-human-carcinoma-cells
#17
Victor Kuete, Leonidah K Omosa, Viviane R Sipowo Tala, Jacob O Midiwo, Armelle T Mbaveng, Sauda Swaleh, Oğuzhan Karaosmanoğlu, Hülya Sivas
BACKGROUND: Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases. METHODS: This study was designed to investigate the cytotoxicity of 14 naturally occurring quinones including; 3 anthraquinones, 1 naphthoquinone and 10 benzoquinones against 6 human carcinoma cell lines and normal CRL2120 fibroblasts. The neutral red uptake (NR) assay was used to evaluate the cytotoxicity of the compounds, whilst caspase-Glo assay was used to detect caspases activation...
December 21, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27997759/down-regulation-of-cladofulvin-biosynthesis-is-required-for-biotrophic-growth-of-cladosporium-fulvum-on-tomato
#18
Scott Griffiths, Carl H Mesarich, Elysa J R Overdijk, Benedetta Saccomanno, Pierre J G M de Wit, Jérôme Collemare
Fungal biotrophy is associated with a reduced capacity to produce potentially toxic secondary metabolites (SMs). Yet, the genome of the biotrophic plant pathogen Cladosporium fulvum contains many SM biosynthetic gene clusters, with several related to toxin production. These gene clusters are, however, poorly expressed during colonisation of tomato. The sole detectable SM produced by C. fulvum during in vitro growth is the anthraquinone cladofulvin. Although this pigment is not detected in infected leaves, cladofulvin biosynthetic genes are expressed throughout the pre-penetration phase and during conidiation at the end of the infection cycle, but they are repressed during the biotrophic phase of tomato colonization...
December 20, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27992673/a-metal-free-non-conjugated-polymer-for-solar-photocatalysis
#19
Julia Perez-Prieto, Rafael Irigoyen, Maria Gonzalez-Bejar, Eduardo Pino, Jose B Proal-Nájera
Heterogeneous catalysts that can absorb light in the solar range are ideal for green photocatalysis. Recently, attention has been directed towards the generation of novel solar-light photocatalysts, in particular metal-free polymers. We demonstrate here that a metal-free, non-conjugated, anthraquinone-based copolymer (COP) with strong absorption in the visible is effective as sunlight heterogeneous photocatalyst. As a proof of concept it has been used to produce mineralization of 2,5-dichlorophenol (2,5-DCP) in water under air and sunlight irradiation...
December 19, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27992117/like-or-dislike-response-of-rodents-to-the-odor-of-plant-secondary-metabolites
#20
Sabine C Hansen, Caroline Stolter, Christian Imholt, Jens Jacob
Rodents, including common voles (Microtus arvalis Pallas, 1778) and house mice (Mus musculus Linnaeus, 1758) cause immense pre- and post-harvest losses. Therefore, developing methods that mitigate these losses while maintaining their role in ecosystems is a priority. Several plant secondary metabolites (PSMs) which significantly reduce food intake of both species under laboratory conditions have been identified. However before these can be used in rodent pest management, they must be tested under more natural conditions where other food sources are available...
December 19, 2016: Integrative Zoology
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