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anthraquinone

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https://www.readbyqxmd.com/read/29777686/molecular-interactions-between-geobacter-sulfurreducens-triheme-cytochromes-and-the-redox-active-analogue-for-humic-substances
#1
Joana M Dantas, Marisa R Ferreira, Teresa Catarino, Oleksandr Kokhan, P Raj Pokkuluri, Carlos A Salgueiro
The bacterium Geobacter sulfurreducens can transfer electrons to the quinone moieties of humic substances or to anthraquinone-2,6-disulfonate (AQDS), a model for the humic acids. The reduced form of AQDS (AH2 QDS) can also be used as energy source G. sulfurreducens. Such bi-directional utilization of humic substances confers competitive advantages to these bacteria in Fe(III) enriched environments. Previous studies have shown that the triheme cytochrome PpcA from G. sulfurreducens has a bi-functional behavior toward the humic substance analogue...
May 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29769013/antidiabetic-effect-of-spearmint-in-streptozotocin-induced-diabetic-rats
#2
Omar Farid, A El Haidani, Mohamed Eddouks
In this work the effect of Mentha spicata (L.) (M. spicata) aerial part aqueous extract (A.P.A.E) at a dose of 20 mg/kg body weight on blood glucose levels has been demonstrated in normal and streptozotocin (STZ) diabetic rats. Additionally, a preliminary phytochemical screening for various bioactive constituents was realized and a dosage of polyphenols and flavonoid has been done. Moreover, the histopathological changes in liver and pancreas have been evaluated both in normal and STZ diabetic rats. The effect of M...
May 16, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29766169/a-new-anthraquinoid-ligand-for-the-iron-catalyzed-hydrosilylation-of-carbonyl-compounds-at-room-temperature-new-insights-and-kinetics
#3
Álvaro Raya-Barón, Carmen P Galdeano-Ruano, Pascual Oña-Burgos, Antonio Rodríguez-Diéguez, Robert Langer, Rosalía López-Ruiz, Roberto Romero-González, Istemi Kuzu, Ignacio Fernández
The reaction of 1-((2-(pyridin-2-yl)ethyl)amino)anthraquinone with either Fe(HMDS)2 or Li(HMDS)/FeCl2 allowed the preparation of a new anthraquinoid-based iron(ii) complex active in the hydrosilylations of carbonyls. The new complex Fe(2)2 was characterized by single-crystal X-ray diffraction, infrared spectroscopy, NMR, and high resolution mass spectrometry (electrospray ionization). Superconducting quantum interference device (SQUID) magnetometry established no spin crossover behavior with an S = 2 state at room temperature...
May 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29760061/methylglucosylation-of-aromatic-amino-and-phenolic-moieties-of-drug-like-biosynthons-by-combinatorial-biosynthesis
#4
Linan Xie, Liwen Zhang, Chen Wang, Xiaojing Wang, Ya-Ming Xu, Hefen Yu, Ping Wu, Shenglan Li, Lida Han, A A Leslie Gunatilaka, Xiaoyi Wei, Min Lin, István Molnár, Yuquan Xu
Glycosylation is a prominent strategy to optimize the pharmacokinetic and pharmacodynamic properties of drug-like small-molecule scaffolds by modulating their solubility, stability, bioavailability, and bioactivity. Glycosyltransferases applicable for "sugarcoating" various small-molecule acceptors have been isolated and characterized from plants and bacteria, but remained cryptic from filamentous fungi until recently, despite the frequent use of some fungi for whole-cell biocatalytic glycosylations...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29758523/glycosides-of-naphthohydroquinones-and-anthraquinones-isolated-from-the-aerial-parts-of-morinda-parvifolia-bartl-ex-dc-rubiaceae-increase-p53-mrna-expression-in-a2780-cells
#5
Xianming Su, Jian Zhang, Changkang Li, Fenghua Li, Hongqing Wang, Haifeng Gu, Baoming Li, Ruoyun Chen, Jie Kang
Eight previously undescribed naphthohydroquinone glycosides, namely morindaparvins H-O, together with four known anthraquinone glycosides were isolated from the n-BuOH extract of the aerial parts of Morinda parvifolia Bartl. ex DC (Rubiaceae). The structures of morindaparvins H-O were elucidated on the basis of spectroscopic analysis. To our knowledge, this is the first isolation of quinone glycosides from the plant M. parvifolia. The results showed that all 12 compounds at the concentration of 50 μM significantly increased p53 mRNA expression in A2780 cells compared with the blank control group...
May 11, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29758413/physcion-8-o-%C3%AE-glucopyranoside-inhibits-clear-cell-renal-cell-carcinoma-bydownregulating-hexokinase-ii-and-inhibiting-glycolysis
#6
Qiang Wang, Yi Yan, Jie Zhang, Peng Guo, Yuqing Xing, Yong Wang, Fawei Qin, Qingyun Zeng
BACKGROUND: Clear-cell renal cell carcinoma (ccRCC) has the highest prevalence, approximately 80%, amongst all RCC cases. Therefore, the development of novel therapeutic agents against ccRCC is imperative. Our previous studies have shown that physcion 8-O-β-glucopyranoside (PG), an anthraquinone extracted from Rumexjaponicus Houtt, exerted an anti-cancer effect in hepatocellular carcinoma cells. The present study was aimed to investigate a possible anti-neoplastic role of PG in ccRCC and the relevant underlying mechanism...
May 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29757991/a-review-the-bioactivities-and-pharmacological-applications-of-polygonatum-sibiricum-polysaccharides
#7
REVIEW
Xiaowei Cui, Shiyuan Wang, Hui Cao, Hong Guo, Yujuan Li, Fangxue Xu, Mengmeng Zheng, Xiaozhi Xi, Chunchao Han
Traditional Chinese Medicine (TCM) has been widely used in China and is regarded as the most important therapeutic. Polygonatum sibiricum (PS), a natural plant used in traditional Chinese medicine, has various functions associated with a number of its components. There are many compositions in PS including polysaccharides, steroids, anthraquinone, alkaloids, cardiac glycosides, lignin, vitamins, various acids, and so on. Of these, polysaccharides play a significant role in PS-based therapeutics. This article summarizes Polygonatum sibiricum polysaccharides (PSP) have many pharmacological applications and biological activities, such as their antioxidant activity, anti-aging activity, an anti-fatigue effect, immunity enhancement effect, antibacterial effect, anti-inflammatory effect, hypolipidemic and antiatherosclerotic effects, anti-osteoporosis effect, liver protection, treatment of diabetes mellitus (DM), anti-cancer effect, and may help prevent Alzheimer's disease, and so on...
May 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29757626/detection-of-redox-state-evolution-during-wound-healing-process-based-on-a-redox-sensitive-wound-dressing
#8
Jie Sun, Shuyan Han, Ying Wang, Guanyu Zhao, Weiping Qian, Jian Dong
To detect the redox state evolution during wound healing process, a redox-sensitive surface-enhanced Raman scattering (SERS) probe was constructed by attaching anthraquinone as a redox-sensitive molecule onto gold nanoshells, and the redox-sensitive SERS probes were loaded on one surface of a chitosan membrane as a redox-sensitive wound dressing. The redox-sensitive wound dressing covered an acute wound as both a wound dressing and a redox state sensor. The spatiotemporal evolution of the redox states of the healing wound was obtained by collecting the SERS spectra of the SERS probes in situ and noninvasively...
May 14, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29754167/an-extract-of-synedrella-nodiflora-l-gaertn-exhibits-antidepressant-properties-through-monoaminergic-mechanisms
#9
Patrick Amoateng, Kennedy Kwami Edem Kukuia, Jeffrey Amoako Mensah, Dorcas Osei-Safo, Samuel Adjei, Audrey Akyea Eklemet, Emmanuel Atsu Vinyo, Thomas K Karikari
Synedrella nodiflora (SNE) has been used traditionally for many neurological conditions and some of these neuroactive effects have been scientifically substantiated. The usefulness of SNE in depression has however not been investigated despite the availability of data in other disease models indicating it may be useful. The present study therefore examined the effect of SNE in acute murine models of depression and the possible mechanisms mediating its activities in these models. Preliminary qualitative phytochemical and high performance liquid chromatography (HPLC) screening were conducted on SNE...
May 12, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29751518/simultaneous-analysis-of-iridoid-glycosides-and-anthraquinones-in-morinda-officinalis-using-uplc-qqq-ms-ms-and-uplc-q-tof-ms-e
#10
Xiangsheng Zhao, Jianhe Wei, Meihua Yang
Morinda officinalis is an important herbal medicine and functional food, and its main constituents include anthraquinone and iridoid glycosides. Quantification of the main compounds is a necessary step to understand the quality and therapeutic properties of M. officinalis , but this has not yet been performed based on liquid chromatography/tandem mass spectrometry (LC-MS/MS). Analytes were extracted from M. officinalis by reflux method. Ultrahigh-performance liquid chromatography coupled with a triple quadrupole mass spectrometry (UPLC-QqQ-MS) using multiple reaction monitoring (MRM) mode was applied for quantification...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29750377/visible-light-catalytic-photooxygenation-of-monoterpene-indole-alkaloids-access-to-spirooxindole-1-3-oxazines
#11
Thorsten von Drathen, Frank Hoffmann, Malte Brasholz
Few natural oxindole alkaloids possess an exceptional spiro-[(1,3)oxazinan-3,6'-oxindole] core structure, which results from an unusual oxidative indole rearrangement. The Rauwolfia alkaloid reserpine can be converted into the spirooxindole-1,3-oxazines dioxyreserpine and trioxyreserpine through efficient visible-light catalytic photooxygenation with anthraquinone photocatalysts. A mechanistic investigation sheds new light on the photooxidative rearrangement of reserpine and related monoterpene indole alkaloids, and the spirooxindole-1,3-oxazine products can be valorized by reductive ring-opening to obtain cis-decahydroisoquinolines as new enantiopure synthetic building blocks, as demonstrated for dioxyreserpine...
May 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29741376/enacting-two-electron-transfer-from-a-tt-state-of-intramolecular-singlet-fission
#12
Hyungjun Kim, Bradley Keller, Rosina Ho-Wu, Neranga Abeyasinghe, Ricardo J Vázquez, Theodore Goodson Iii, Paul M Zimmerman
A simulation-led strategy enacts two-electron transfer between an intramolecular singlet fission chromophore (tetracyanomethylene quinoidal bithiopehene with β,β'-solubilizing groups) and multi-electron acceptor (anthraquinone). The thermodynamic plausibility of multi-electron transfer from a double-triplet state and the absorption spectra of electron transfer (ET) products were predicted using quantum chemical simulations. These predictions are consistent with experimental observations of reduced lifetimes in time-resolved fluorescence spectroscopy, changes in transmission profile, and appearance of new absorption bands in transient absorption spectroscopy, all of which support multi-ET in the QOT2/AQ mixture...
May 9, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29736381/usage-biological-activity-and-safety-of-selected-botanical-dietary-supplements-consumed-in-the-united-states
#13
REVIEW
P Annécie Benatrehina, Li Pan, C Benjamin Naman, Jie Li, A Douglas Kinghorn
In view of the continuous growth of the botanical dietary supplement industry and the increased popularity of lesser known or exotic botanicals, recent findings are described on the phytochemical composition and biological activities of five selected fruits consumed in the United States, namely, açaí, noni, mangosteen, black chokeberry, and maqui berry. A review of the ethnomedicinal uses of these plants has revealed some similarities ranging from wound-healing to the treatment of fever and infectious diseases...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29732621/photoredox-reaction-of-quinones
#14
Yoshio Ando, Keisuke Suzuki
Photoredox reactions of quinones are reviewed, that enable C-H bond oxidation at the vicinity of the excited quinone carbonyl and concomitant reduction of the quinone under photoirradiation. Mechanistic insights on the benzo-, naphtho-, and anthraquinones are discussed. Also the potential utilities in organic synthesis are described.
May 6, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29732107/nanopore-induced-host-guest-charge-transfer-phenomena-in-a-metal-organic-framework
#15
S Yamamoto, J Pirillo, Y Hijikata, Z Zhang, K Awaga
A spontaneous entrapment of electron-donating small guest molecules, including tetrathiafulvalene (TTF) and N , N , N ', N '-tetramethyl-1,3-propanediamine (TMPDA), was realized in a structurally flexible metal-organic framework, {Mn7 (2,7-AQDC)6 (2,6-AQDC)(DMA)6 }∞ (AQDC = anthraquinone dicarboxylates, DMA = N , N -dimethylacetamide), with electron-accepting anthraquinone groups, generating two MOF guest charge transfer complexes: {Mn7 (2,7-AQDC)6 (2,6-AQDC)(DMA)6 (TTF)5 } and {Mn7 (2,7-AQDC)6 (2,6-AQDC)(DMA)4 (H2 O)2 (TMPDA)7 }...
April 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29730698/klotho-preservation-by-rhein-promotes-toll-like-receptor-4-proteolysis-and-attenuates-lipopolysaccharide-induced-acute-kidney-injury
#16
Fangfang Bi, Fang Chen, Yanning Li, Ai Wei, Wangsen Cao
Renal anti-aging protein Klotho exhibits impressive properties of anti-inflammation and renal protection, however is suppressed early after renal injury, making Klotho restoration an attractive strategy of treating renal inflammatory disorders. Here, we reported that Klotho is enriched in macrophages and Klotho preservation by Rhein, an anthraquinone derived from medicinal plant rhubarb, attenuates lipopolysaccharide (LPS)-induced acute inflammation essentially via promoting toll-like receptor 4 (TLR4) degradation...
May 5, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29727648/ligand-induced-glutathione-transferase-degradation-as-a-therapeutic-modality-investigation-of-a-new-metal-mediated-affinity-cleavage-strategy-for-human-gstp1-1
#17
Mohamed Hamed Alqarni, Magdy Mohamed Muharram, Nikolaos E Labrou
Glutathione transferases (GST, EC. 2.5.1.18) are overexpressed in cancer cell and have been shown to be involved in cancer cell growth, differentiation and the development of multi-drug resistance (MDR) mechanism. Therefore, GST inhibitors are emerging as promising chemosensitizers to manage and reverse MDR. The present work aims to the synthesis, characterization and assessment of a new active-site chimeric inhibitor towards the MDR-involved human GSTP1-1 isoenzyme (hGSTP1-1). The inhibitor [BDA-Fe(III)] was designed to possess two functional groups: the anthraquinone moiety, as recognition element by hGSTP1-1 and a metal chelated complex [iminodiacetic acid-Fe(III)] as a reactive moiety, able to generate reactive oxygen species (ROS), through Fenton reaction...
May 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29717199/antibacterial-anthraquinone-derivatives-isolated-from-a-mangrove-derived-endophytic-fungus-aspergillus-nidulans-by-ethanol-stress-strategy
#18
Sui-Qun Yang, Xiao-Ming Li, Gang-Ming Xu, Xin Li, Chun-Yan An, Bin-Gui Wang
Three new natural products, including a new anthraquinone derivative isoversicolorin C (1), a new xanthone analog isosecosterigmatocystin (2), and a new amino acid derivative, glulisine A (3), along with six related metabolites (4-9) were isolated from the culture broth and mycelia extracts of the mangrove-derived endophytic fungus Aspergillus nidulans MA-143 under 0.1% ethanol stress. Their structures were elucidated by detailed analysis of their NMR spectra, ECD spectrum, and X-ray crystallographic experiments...
May 1, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29707146/aloe-emodin-as-drug-candidate-for-cancer-therapy
#19
Nadire Özenver, Mohamed Saeed, Lütfiye Ömur Demirezer, Thomas Efferth
As a leading cause of global mortality, cancer frequently cannot be cured due to the development of drug resistance. Therefore, novel drugs are required. Naturally occurring anthraquinones are mostly present in Rumex and Rhamnus species and are of interest because of their structural similarity to anthracyclines as well established anticancer drugs. In the present study, we focused on the structural elucidation of phytochemicals from R. acetosella as well as the investigation of cytotoxicity and modes of action of the main anthraquinone aglycons (emodin, Aloe-emodin, physcion, rhein)...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29707033/-syzygium-jambos-displayed-antibacterial-and-antibiotic-modulating-activities-against-resistant-phenotypes
#20
Brice E N Wamba, Paul Nayim, Armelle T Mbaveng, Igor K Voukeng, Joachim K Dzotam, Ornella J T Ngalani, Victor Kuete
The present study was designed to evaluate the antibacterial activities of methanol extracts of bark and leaves of Syzygium jambos , as well as their synergistic effects with selected antibiotics against drug-resistant Gram-positive and Gram-negative bacteria. The crude extracts were subjected to qualitative phytochemical screening; broth microdilution method was used for antibacterial assays. Phytochemical studies indicate that leaves and bark extracts contained polyphenols, anthraquinones, tannins, and steroids...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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