Read by QxMD icon Read


Barbara S Janović, Milica Lj Mićić Vićovac, Zoran M Vujčić, Miroslava T Vujčić
Peroxidases (EC have enormous biotechnological applications. Usage of more abundant, basic isoforms of peroxidases in diagnostic kits and/or in immunochemistry has led to under exploitation and disregard of horseradish peroxidase (HRP) acidic isoforms. Therefore, acidic horseradish peroxidase (HRP-A) isoenzyme was used for the preparation of a biocatalyst with improved ability in dye decolorization. Ten biocatalysts were prepared by covalent binding of enzyme to chitosan and alginate, adsorption followed by cross-linking on inorganic support (aluminum oxide), and encapsulation in spherical calcium alginate beads via polyethylene glycol...
December 1, 2016: Environmental Science and Pollution Research International
Takaaki Taguchi, Takayoshi Awakawa, Yukitaka Nishihara, Michiho Kawamura, Yasuo Ohnishi, Koji Ichinose
Type II polyketide synthase (PKS) iteratively generates a nascent polyketide thioester of acyl carrier protein (ACP), which is structurally modified to produce an ACP-free intermediate towards its final metabolite. However, the timing of ACP off-loading is not well defined due to the lack of an apparent thioesterase (TE) among relevant biosynthetic enzymes. Here, ActIV, which had been assigned as a second ring cyclase (CYC) in actinorhodin (ACT) biosynthesis, was shown to possess a TE activity in vitro with a model substrate, anthraquinone-2-carboxylic acid-N-acetylcysteamine...
November 29, 2016: Chembiochem: a European Journal of Chemical Biology
Phi-Hung Nguyen, Hong Seok Choi, Thi Kim Quy Ha, Ji Yeon Seo, Jun-Li Yang, Da-Woon Jung, Darren R Williams, Won-Keun Oh
AMP-activated protein kinase (AMPK) activators are known to increase energy metabolism and to reduce body weight, as well as to improve glucose uptake. During for searching AMPK activators, a new anthraquinone, modasima A (10), along with eighteen known analogues (1-9 and 11-19) were isolated from an ethanol extract of the roots of Morinda longissima Y. Z. Ruan (Rubiaceae). Using the fluorescent tagged glucose analogues, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxy-D-glucose (2-NBDG), insulin mimetics were screened with compounds 1-19 in 3T3-L1 adipocytes...
November 15, 2016: Bioorganic & Medicinal Chemistry Letters
Dalia I Sánchez-Machado, Jaime López-Cervantes, María F Mariscal-Domínguez, Paola Cruz-Flores, Olga N Campas-Baypoli, Ernesto U Cantú-Soto, Ana Sanches-Silva
Aloin is an anthraquinone-C-glycoside present in Aloe vera This compound is extremely variable among different species and highly depends on the growing conditions of the plants. The quantification of aloin in different extraction preparations has been a frequent problem due to the high instability of the compound. The aim of the present study is to develop and validated an analytical method for aloin detection in fresh and dry samples of Aloe barbadensis gel and latex using high performance liquid chromatography coupled to a diode array detector (HPLC-DAD)...
November 24, 2016: Journal of Chromatographic Science
Sachinath Bera, Suvendu Maity, Thomas Weyhermüller, Prasanta Ghosh
Radical and non-radical ruthenium and osmium complexes of 1-amino-9,10-anthraquinone (AqNH2), which is defined as a molecule of dual radical counter, are disclosed. 1-Amido-9,10-anthraquinone (AqNH(-)) complexes of the types trans-[Ru(II)(AqNH(-))(PPh3)2(CO)Cl] (1), trans-[Os(II)(AqNH(-))(PPh3)2(CO)Br] (2) and trans-[Ru(III)(AqNH(-))(PPh3)2Cl2] (3) were isolated. AqNH(-) of 1-3 is redox active and undergoes oxidation reversibly at +(0.05-0.35) V to the 1-amino-9,10-anthraquinone radical (AqNH˙) and reduction at -(0...
November 24, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Wanfu Lin, Maofeng Zhong, Shufang Liang, Yongan Chen, Dong Liu, Zifei Yin, Qingxin Cao, Chen Wang, Changquan Ling
Emodin, an anthraquinone derivative from the root and rhizome of Rheum palmatum L., was found to have antitumor effects in different types of cancer by regulating multi-molecular targets. The aim of the present study was to explore the effect of emodin on the migration and invasion of MHCC-97H human hepatocellular carcinoma cells and the underlying molecular mechanisms. Firstly, it was demonstrated that emodin can inhibit cell proliferation and induce apoptosis of cells in a time- and dose-dependent manner, using a MTT assay and flow cytometry, respectively...
November 2016: Experimental and Therapeutic Medicine
Xianghui Li, Weilin Guo, Zhonghua Liu, Ruiqin Wang, Hua Liu
A novel quinone-modified metal-organic frameworks NH2-MIL-101(Fe) was synthesized using a simple chemical method under mild condition. The introduced 2-anthraquinone sulfonate (AQS) can be covalently modified with NH2-MIL-101(Fe) and acts as a redox mediator to enhance the degradation of bisphenol A (BPA) via persulfate activation. The obtained AQS-NH-MIL-101(Fe) was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectra, cyclic voltammetry and electrochemical impedance spectroscopy...
November 15, 2016: Journal of Hazardous Materials
Jian Sun, Bihai Cai, Wenjing Xu, Yu Huang, Yaping Zhang, Yenping Peng, Kenlin Chang, Jiahong Kuo, Kufan Chen, Xunan Ning, Guoguang Liu, Yujie Wang, Zuoyi Yang, Jingyong Liu
A novel anthraquinone-2,6-disulfonate/MnOx-doped polypyrrole film (AQDS/Mn/PPy) electrode was prepared by one-step electropolymerization method and was used to improve performance of a reversible photo-bioelectrochemical cell (RPBEC). The RPBEC was operated in polarity reversion depended on dark/light reaction of alga Chlorella vulgaris by which sequential decolorization of azo dye and mineralization of decolorization products coupled with bioelectricity generation can be achieved. The results showed that formation of uniform AQDS/Mn/PPy film significantly enhanced electroactive surface area and electrocatalytic activity of carbon electrode...
November 10, 2016: Bioresource Technology
V Duraipandiyan, Naif Abdullah Al-Dhabi, S Ignacimuthu
The present report is about Streptomyces sp. isolate ERI-26 isolated from the soil sample of Nilgiri forest, Western Ghats. The methanol extract of ERI-26 showed good antimicrobial activity against tested microbes. The antimicrobial novel anthraquinones were purified by bioactivity-guided fractionation using a silica gel column and preparative HPLC. The compound was characterized and identified by UV, IR, NMR and MASS spectral data. The compound named as 6,6(1)-bis (1,5,7-trihydroxy-3-hydroxymethylanthraquinone), showed significant antimicrobial activities against tested microbes...
November 2016: Saudi Journal of Biological Sciences
Nor Aijratul Asikin Mohamad Shalan, Noordin M Mustapha, Suhaila Mohamed
Noni (Morinda citrifolia) leaf and fruit are used as food and medicine. This report compares the chronic toxicity of Noni fruit and edible leaf water extracts (two doses each) in female mice. The 6 months study showed the fruit extract produced chronic toxicity effects at the high dose of 2 mg/ml drinking water, evidenced through deteriorated liver histology (hepatocyte necrosis), reduced liver length, increased liver injury marker AST (aspartate aminotransferase) and albumin reduction, injury symptoms (hypoactivity, excessive grooming, sunken eyes and hunched posture) and 40% mortality within 3 months...
November 18, 2016: Regulatory Toxicology and Pharmacology: RTP
Morena Mischitelli, Mohamed Jemaà, Mustafa Almasry, Caterina Faggio, Florian Lang
BACKGROUND/AIMS: The natural anthraquinone derivative emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a component of several Chinese medicinal herbal preparations utilized for more than 2000 years. The substance has been used against diverse disorders including malignancy, inflammation and microbial infection. The substance is effective in part by triggering suicidal death or apoptosis. Similar to apoptosis of nucleated cells erythrocytes may enter suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface...
2016: Cellular Physiology and Biochemistry
Muthu Thiruvengadam, Kaliyaperumal Rekha, Govindasamy Rajakumar, Taek-Jun Lee, Seung-Hyun Kim, Ill-Min Chung
Anthraquinones (AQs) and phenolic compounds are important phytochemicals that are biosynthesized in cell suspension cultures of Polygonum multiflorum. We wanted to optimize the effects of plant growth regulators (PGRs), media, sucrose, l-glutamine, jasmonic acid (JA), and salicylic acid (SA) for the production of phytochemicals and biomass accumulation in a cell suspension culture of P. multiflorum. The medium containing Murashige and Skoog (MS) salts and 4% sucrose supplemented with 1 mg/L 2,4-dichlorophenoxyacetic acid, 0...
November 16, 2016: International Journal of Molecular Sciences
Jie-Ping Lei, Guo-Qing Wei, Juan-Juan Yuan, Kang-Zhi Tan, Qiao-Yu Chen, Tao Zhang, Chao-Ying Ma, He-Zhong Jiang
The present study was designed to investigate the chemical constituents of Lindera nacusua and their antitumor activities. A new phenolic glycoside, namely 1-O-3-hydroxyphenyl-5-methoxyphenol-(6'-O-vanilloyl)-β-d-glucopyranoside (1), together with five known phenolic glycosides (2-6), two anthraquinones (7, 8) and two γ-butanolides (9, 10), was isolated, and its structure was elucidated by spectroscopic and chemical methods. Compounds 1-10 were screened for their in vitro cytotoxicities against HL-60, SMMC-7721, A549, MCF-3 and SW480 cell lines by the MTS method...
November 7, 2016: Natural Product Research
Mackenzie J Field, Soumalya Sinha, Jeffrey J Warren
Selective functionalization of unactivated C-H bonds is an ongoing chemical challenge. C-H activation requires the transfer of H(+) and e(-), so called proton-coupled electron transfer (PCET) reactions. Recent efforts in photochemical PCET involving C-H bonds show great promise for the synthesis of new compounds. One such example is photochemical C-H fluorination reactions. In many cases, the discrete PCET mechanisms are yet to be defined in a systematic way. Here, we investigated electron transfer (ET) and PCET reactions of electronically excited 1,2,4,5-tetracyanobenzene and anthraquinone with the components of typical fluorination reactions...
November 16, 2016: Physical Chemistry Chemical Physics: PCCP
Javier A García-Vilas, Almudena Pino-Ángeles, Beatriz Martínez-Poveda, Ana R Quesada, Miguel Ángel Medina
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting further insight on the inhibitory effect of damnacanthal on three different kinases: vascular endothelial growth factor receptor-2, c-Met and focal adhesion kinase. Several of the kinases targeted and inhibited by damnacanthal are involved in angiogenesis. Ex vivo and in vivo experiments clearly demonstrate that, indeed, damnacanthal is a very potent inhibitor of angiogenesis...
November 2, 2016: Cancer Letters
Chao Luo, Qiming Yu, Hongming Wang
Polycyclic aromatic hydrocarbons (PAHs) and oxygenated-PAHs are globally worrisome air pollutants because of their highly direct-acting mutagenicity and carcinogenicity. The formation of oxygenated-PAHs is of crucial importance for the prevention of their atmospheric pollution successfully. In this paper, the formation mechanism of oxygenated-PAHs from the heterogeneous reaction of NO2 with anthracene on the surface of NaCl was studied by density functional theory (DFT) calculations. At first, the various adsorption configurations of NO2 and N2O4 on NaCl were investigated...
November 4, 2016: Environmental Science. Processes & Impacts
He Yan, Yang Li, Xing Y Zhang, Wan Y Zhou, Tao J Feng
No abstract text is available yet for this article.
November 2, 2016: Journal of Antibiotics
Daizong Cui, Hao Zhang, Rubao He, Min Zhao
An anaerobic sludge (AS), capable of decolorizing a variety of synthetic dyes, was acclimated and is reported here. The sludge presented a much better dye decolorizing ability than that of different individual strains. A broad spectrum of dyes could be decolorized by the sludge. Continuous decolorization tests showed that the sludge exhibited the ability to decolorize repeated additions of dye. The chemical oxygen demand (COD) removal rate of the dye wastewater reached 52% after 12 h of incubation. Polymerase chain reaction and denaturing gradient gel electrophoresis (PCR-DGGE) profiles revealed that the microbial community changed as a result of varying initial concentrations of dyes...
October 28, 2016: International Journal of Environmental Research and Public Health
Howell G M Edwards, Dolores Elkin, Marta S Maier
Specimens from underwater archaeological excavations have rarely been analysed by Raman spectroscopy probably due to the problems associated with the presence of water and the use of alternative techniques. The discovery of the remains of the Royal Navy warship HMS Swift off the coast of Patagonia, South America, which was wrecked in 1770 while undertaking a survey from its base in the Falkland/Malvinas Islands, has afforded the opportunity for a first-pass Raman spectroscopic study of the contents of several glass jars from a wooden chest, some of which had suffered deterioration of their contents owing to leakage through their stoppers...
December 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Chao-Yi Wang, Kai-Ling Wang, Pei-Yuan Qian, Ying Xu, Min Chen, Juan-Juan Zheng, Min Liu, Chang-Lun Shao, Chang-Yun Wang
Marine organism-derived secondary metabolites are promising potential sources for discovering environmentally safe antifouling agents. In present study, 55 marine secondary metabolites and their synthesized derivatives were tested and evaluated for their antifouling activities and security. These compounds include 44 natural products isolated from marine invertebrates and their symbiotic microorganisms collected from the South China Sea and 11 structural modified products derived from the isolated compounds...
December 2016: AMB Express
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"