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https://www.readbyqxmd.com/read/28544417/rapid-discovery-and-identification-of-the-prototypes-and-their-metabolites-of-da-huang-xiao-shi-decoction-in-rat-plasma-by-an-integrative-strategy-based-on-liquid-chromatography-coupled-with-mass-spectrometry
#1
Dan Wang, Qingshui Shi, Fang Feng
Da-Huang-Xiao-Shi decoction has been used to treat damp-heat jaundice for centuries in China. However, the absorbed components of the decoction and their related metabolites are little known till now. In this work, an integrative strategy based on liquid chromatography coupled with mass spectrometry (time-of-flight/triple-quadruple tandem) was adopted to effectively identify the prototypes and their metabolites and to speculate the possible transformation pathways among these compounds. Using pattern recognition approaches, the exogenous compounds in rat plasma were screened out from endogenous compounds and then distinguished into prototypes and metabolites according to the characteristic information from the self-building database of Da-Huang-Xiao-Shi decoction...
May 24, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28535423/chromatographic-separation-and-detection-methods-of-aloe-arborescens-miller-constituents-a-systematic-review
#2
REVIEW
Jilan A Nazeam, Haidy A Gad, Hala M El-Hefnawy, Abdel-Naser B Singab
Aloe arborescens Miller (Family Asphodelaceae) is a member of genus Aloe, which is used in traditional medicine to cure various diseases. The extracts of the plant have been reported to possess anticancer, immunomodulator, antidiabetic, anti-inflammatory and antioxidant activities. The phytochemical investigations have revealed diverse chemical constituents, including phenolics [anthraquinones, anthrones, pyrones, chromones and coumarins], polysaccharides [arborans [(1-4) linked glucomannans, polysaccharide (A, B and C): (A: a linear (1-6)-O-α-glucan, B: a branching (1-2)-O-l-arabinose with (1-2)-O-d-galactose linkages and C: (1-4)-O-β-mannan with 18% acetyl group)]], glycoproteins and carboxypeptidase enzyme...
April 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28515022/sos-response-in-bacteria-inhibitory-activity-of-lichen-secondary-metabolites-against-escherichia-coli-reca-protein
#3
Pierangelo Bellio, Letizia Di Pietro, Alisia Mancini, Marisa Piovano, Marcello Nicoletti, Fabrizia Brisdelli, Donatella Tondi, Laura Cendron, Nicola Franceschini, Gianfranco Amicosante, Mariagrazia Perilli, Giuseppe Celenza
BACKGROUND: RecA is a bacterial multifunctional protein essential to genetic recombination, error-prone replicative bypass of DNA damages and regulation of SOS response. The activation of bacterial SOS response is directly related to the development of intrinsic and/or acquired resistance to antimicrobials. Although recent studies directed towards RecA inactivation via ATP binding inhibition described a variety of micromolar affinity ligands, inhibitors of the DNA binding site are still unknown...
June 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28513684/ultrafast-ir-spectroscopy-of-photo-induced-electron-transfer-in-self-assembled-donor-acceptor-coordination-cages
#4
J Ahrens, M Frank, G H Clever, D Schwarzer
Photo-induced processes in self-assembled coordination cages were studied by femtosecond infrared pump-probe spectroscopy. Densely packed, interpenetrated double cages were constructed from eight bis-monodentate redoxactive ligands bound to four Pd(ii) nodes. Two types of ligands consisting of electron rich phenothiazine (PTZ) or electron deficient anthraquinone (ANQ) chromophores were used to assemble either homo-octameric or mixed-ligand cages. Upon photoexcitation the homo-octameric acceptor cage undergoes intersystem crossing to a long-lived triplet state, similar to the free acceptor ligand...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28513475/self-assembling-graphene-anthraquinone-2-sulphonate-supramolecular-nanostructures-with-enhanced-energy-density-for-supercapacitors
#5
Li Niu, Lifang Gao, Shiyu Gan, Hongyan Li, Dongxue Han, Fenghua Li, Yu Bao
Boosting the energy density remains a crucial issue for facilitating applications of capacitive energy storage devices. Herein, we report a graphene-anthraquinone supramolecular nanostructure by self-assembly for supercapacitors. The sulfonated anthraquinone exhibits high water solubility, π-conjugated structure and redox active features, which not only serves as a spacer to interact and stabilize graphene but also introduces extra contribution of pesudocapacitance. The formed nest-like three-dimensional (3D) nanostructure by further hydrothermal treatment enhances the accessibility of ion transfers and exposes the redox-active quinone groups into electrolytes...
May 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28512605/toxicity-status-and-antiulcerative-potential-of-sansevieria-trifasciata-leaf-extract-in-wistar-rats
#6
Osasenaga Macdonald Ighodaro, Abiola Muhammad Adeosun, Barinemene Francis Ojiko, Abeeb Taiwo Akorede, Oyindamola Fuyi-Williams
AIMS: The lethal dose 50% (LD50) and antiulcerative potentials of Sansevieria trifasciata (ST) leaf extract were investigated. MATERIALS AND METHODS: LD50 was determined through two routes of administration (intraperitoneal [i.p] and oral [p.o]) using the method of Lorke. The antiulcerative activity was evaluated in indomethacin-induced ulcer model (40 mg/kg body weight [BW], i.p, single dose) against a reference drug, cimetidine (100 mg/kg BW, p.o). ST was assessed at two different doses (200 and 400 mg/kg BW, p...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28511613/antimicrobial-activity-and-molecular-docking-studies-of-a-novel-anthraquinone-from-a-marine-derived-fungus-aspergillus-versicolor
#7
Weiyi Wang, Ruixuan Chen, Zhuhua Luo, Wei Wang, Jianming Chen
A novel anthraquinone, 2-(dimethoxymethyl)-1-hydroxyanthracene-9,10-dione (1), together with nine known compounds (2-10), were isolated from the fermentation of Aspergillus versicolor derived from deep sea sediment. Their structures were established through spectroscopic methods. Compound 1 exhibited strong inhibitory activities against MRSA ATCC 43300 and MRSA CGMCC 1.12409 (with MIC values of 3.9 and 7.8 μg/mL respectively) and moderate activities against tested strains of Vibrio (with MIC values ranging from 15...
May 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28509846/a-new-ergosterol-analog-a-new-bis-anthraquinone-and-anti-obesity-activity-of-anthraquinones-from-the-marine-sponge-associated-fungus-talaromyces-stipitatus-kufa-0207
#8
Jidapa Noinart, Suradet Buttachon, Tida Dethoup, Luís Gales, José A Pereira, Ralph Urbatzka, Sara Freitas, Michael Lee, Artur M S Silva, Madalena M M Pinto, Vítor Vasconcelos, Anake Kijjoa
A new ergosterol analog, talarosterone (1) and a new bis-anthraquinone derivative (3) were isolated, together with ten known compounds including palmitic acid, ergosta-4,6,8(14),22-tetraen-3-one, ergosterol-5,8-endoperoxide, cyathisterone (2), emodin (4a), questinol (4b), citreorosein (4c), fallacinol (4d), rheoemodin (4e) and secalonic acid A (5), from the ethyl acetate extract of the culture of the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207. The structures of the new compounds were established based on extensive 1D and 2D spectral analysis, and in the case of talarosterone (1), the absolute configurations of its stereogenic carbons were determined by X-ray crystallographic analysis...
May 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28509552/amino-acid-conjugated-anthraquinones-from-the-marine-derived-fungus-penicillium-sp-scsio-sof101
#9
Minghe Luo, Zhaomeng Cui, Hongbo Huang, Xianqin Song, Aijun Sun, Yongjun Dang, Laichun Lu, Jianhua Ju
Emodacidamides A-H (1-8), natural products featuring anthraquinone-amino acid conjugates, have been isolated from a marine-derived fungus, Penicillium sp. SCSIO sof101, together with known anthraquinones 9 and 10. The planar structures of 1-8 were elucidated using a combination of NMR spectroscopy and mass spectrometry. The absolute configurations of the amino acid residues were confirmed using Marfey's method and chiral-phase HPLC analyses. Additionally, isolates were evaluated for possible immunomodulatory and cytotoxic activities...
May 16, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28501689/obtaining-titanium-dioxide-nanoparticles-with-spherical-shape-and-antimicrobial-properties-using-m-citrifolia-leaves-extract-by-hydrothermal-method
#10
Sundrarajan M, Bama K, Bhavani M, Jegatheeswaran S, Ambika S, Sangili A, Nithya P, Sumathi R
In this work, we synthesized titanium dioxide (TiO2) nanoparticles using leaf extract of Morinda citrifolia (M. citrifolia) by the advanced hydrothermal method. The synthesized TiO2 nanoparticles were characterized by X-ray diffraction (XRD), Fourier transmission infrared (FT-IR), Ultraviolet-visible diffuse reflectance (UV-Vis DRS), Ultraviolet-visible spectroscopy (UV-Vis), Raman spectroscopy, and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM with EDX) techniques. The XRD major peak at 27...
May 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28497836/visible-light-initiated-release-of-calcium-ions-through-photochemical-electron-transfer-reactions
#11
Romina R Heymann, Matthew D Thum, Apryl L Hardee, Daniel E Falvey
Photolysis of anthraquinone or flavin photosensitizers in the presence of calcium EDTA complexes results in decomposition of the EDTA complex, releasing free Ca(2+). In the case of the flavin sensitizers, it is shown that millimolar concentrations of Ca(2+) can be released using visible light (>440 nm) and with quantum yields as high as 0.31. The utility of this system is further demonstrated by in situ photogelation of an alginate solution.
May 12, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28497499/applying-characteristic-fragment-filtering-for-rapid-detection-and-identification-of-ingredients-in-rhubarb-by-hplc-coupled-with-linear-ion-trap-orbitrap-mass-spectrometry
#12
Qing Wang, Zhiwei Lu, Li Zhang, Qingqing Zhang, Meiling Wang, Huizhen Zhao, Yuehong Liu, Shuang Fu, Zhenghai Huang, Ziye Xie, Honghong Yu, Zhixin Zhang, Xiaoyan Gao
Chemical characteristic fragment filtering in MS(n) chromatograms was proposed to detect and identify the components in rhubarb rapidly using high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry. Characteristic fragments consist of diagnostic ions and neutral loss fragments. Characteristic fragment filtering is a post-acquisition data mining method for the targeted screening of groups with specific structures, including three steps: first, in order to comprehensively summarize characteristic fragments for global identification of the ingredients in rhubarb, representative authentic standards of dominant chemical categories contained in rhubarb were chosen, from which fragmentation rules and a characteristic fragments schedule were proposed; second, characteristic fragment filtering was used to rapidly recognize analogous skeletons; finally, combined with retention time, accurate mass, characteristic fragments and previous literature, the structures of the filtered compounds were identified or tentatively characterized...
May 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28488743/photoisomerisation-of-bis-tridentate-2-6-bis-1h-pyrazol-1-yl-pyridine-ligands-exhibiting-a-multi-anthracene-skeleton
#13
Ivan Salitros, Olaf Fuhr, Miroslav Gal, Michal Valasek, Mario Ruben
A novel molecular design is described where two peripheral moieties made of 2,6-bis(1H-pyrazol-1-yl)pyridine are linked via a multi-1,8-diethynylanthracene moieties. The optimized synthesis of the three isostructural analogues 1a, 1b and 1c, containing the respective anthraquinone, anthracene and 10-methoxyanthracene units, is reported. The resulting spatial face-to-face arrangement of the peripheral anthracene rings enables to trigger the intramolecular [4+4] photocycloadition affording P1b and P1c isomers, which can be thermally cleaved back to the original anthracene derivatives 1b and 1c...
May 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28487948/effect-of-aloe%C3%A2-emodin-on-the-proliferation-and-apoptosis-of-human-synovial-mh7a-cells-a-comparison-with-methotrexate
#14
Motoko Hashiguchi, Kaori Suzuki, Kazuo Kaneko, Isao Nagaoka
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia. Methotrexate (MTX), an antifolate derivative, is used for the treatment of RA, as it exerts antiproliferative efftects on lymphocytes and synovial cells. Aloe‑emodin (AE) is a primary component of anthraquinones in Aloe vera and exerts antiproliferative and apoptotic effects on various tumor cells. In the present study, the effect of AE on the proliferation and apoptosis of MH7A human RA synovial cells was examined...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28485323/rhubarb-monomers-protect-intestinal-mucosal-barrier-in-sepsis-via-junction-proteins
#15
Lyu Wang, Yun-Liang Cui, Zhe Zhang, Zhao-Fen Lin, De-Chang Chen
BACKGROUND: Leakage of the intestinal mucosal barrier may cause translocation of bacteria, then leading to multiorgan failure. This study hypothesized that rhubarb monomers might protect the gut mucosal barrier in sepsis through junction proteins. METHODS: Healthy male Sprague-Dawley rats (weighing 230-250 g) under anesthesia and sedation were subjected to cecal ligation and perforation (CLP). After surgical preparation, rats were randomly assigned to eight groups (n = 6 or 8 each group): sham group (Group A: normal saline gavage); sepsis group (Group B: normal saline gavage); Group C (intraperitoneally, dexamethasone 0...
May 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28475921/pharmacokinetics-and-pharmacodynamics-of-rhubarb-anthraquinones-extract-in-normal-and-disease-rats
#16
Peijin Li, Qianfeng Lu, Wenjiao Jiang, Xue Pei, Yilin Sun, Haiping Hao, Kun Hao
BACKGROUND: Anthraquinones extract from Rheum palmatum L. (rhubarb) including rhein, emodin, aloe-emodin, chrysophanol, physcion and sennoside A, has been widely used in China to treat various diseases. OBJECTIVE: This study was designed to explore the pharmacokinetic and pharmacodynamic properties of rhubarb anthraquinones extract in diabetic nephropathy and acute liver injury rats. METHODS: The diabetic nephropathy and acute liver injury rats were induced by intraperitoneal injection with streptozotocin (STZ) and carbon tetrachloride (CCL4), respectively...
May 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28474782/a-comparative-pharmacokinetic-study-of-three-flavonoids-and-three-anthraquinones-in-normal-and-gastrointestinal-motility-disorders-rat-plasma-after-the-oral-administration-of-wei-chang-shu-tablet-using-high-performance-liquid-chromatography-tandem-mass-spectrometry
#17
Yan Ren, Weiwei Zhao, Juanjuan Zhao, Xiangming Chen, Chen Yu, Mengan Liu
A simple, fast and reliable high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification and pharmacokinetic study of three flavonoids (liquiritigenin, isoliquiritigenin and formononetin) and three anthraquinones (emodin, rhein and aloe-emodin), which are the bioactive ingredients of Wei-Chang-Shu tablet found in rat plasma. After extraction by liquid-liquid extraction with ethyl acetate, chromatographic separation was achieved on an Agilent ZORBAX SB-C18 column (4...
May 5, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28470283/a-density-functional-theory-study-on-the-thermodynamic-and-dynamic-properties-of-anthraquinone-analogue-cathode-materials-for-rechargeable-lithium-ion-batteries
#18
Shu-Jing Yang, Xiao-Ya Qin, Rongxing He, Wei Shen, Ming Li, Liu-Bin Zhao
Organic redox compounds have become the emerging electrode materials for rechargeable lithium ion batteries. The high electrochemical performance provides organic electrode materials with great opportunities to be applied in electric energy storage devices. Among the different types of organic materials, conjugated carbonyl compounds are the most promising type at present, because only they can simultaneously achieve, high energy density, high cycling stability, and high power density. In this research, a series of heteroatom substituted anthraquinone (AQ) derivatives were designed theoretically so that the high theoretical capacity of AQ remained...
May 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28465625/new-chlorinated-xanthone-and-anthraquinone-produced-by-a-mangrove-derived-fungus-penicillium-citrinum-hl-5126
#19
Ke-Yao He, Cheng Zhang, Yi-Ru Duan, Guo-Lei Huang, Chun-Yan Yang, Xing-Rui Lu, Cai-Juan Zheng, Guang-Ying Chen
Two new chlorinated metabolites 4-chloro-1-hydroxy-3-methoxy-6-methyl-8-methoxycarbonyl-xanthen-9-one (1) and 2'-acetoxy-7-chlorocitreorosein (2), together with three known compounds (3-5), were obtained from the EtOAc extract of the endophytic fungus Penicillium citrinum HL-5126 isolated from the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were evaluated for their antibacterial and topoisomerase I inhibitory activities...
May 3, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28464813/antidiabetic-activity-and-phytochemical-screening-of-extracts-of-the-leaves-of-ajuga-remota-benth-on-alloxan-induced-diabetic-mice
#20
Tadesse Bekele Tafesse, Ariaya Hymete, Yalemtsehay Mekonnen, Mekuria Tadesse
BACKGROUND: Ajuga remota Benth is traditionally used in Ethiopia for the management of diabetes mellitus. Since this claim has not been investigated scientifically, the aim of this study was to evaluate the antidiabetic effect and phytochemical screening of the aqueous and 70% ethanol extracts on alloxan-induced diabetic mice. METHODS: After acute toxicity test, the Swiss albino mice were induced with alloxan to get experimental diabetes animals. The fasting mean blood glucose level before and after treatment for two weeks in normal, diabetic untreated and diabetic mice treated with aqueous and 70% ethanol extracts were performed...
May 2, 2017: BMC Complementary and Alternative Medicine
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