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https://www.readbyqxmd.com/read/28315491/vibrating-mesh-nebulizer-maintenance-by-cf-patients-results-from-a-french-survey
#1
Melisande Baravalle-Einaudi, Nadine Dufeu, Christian Dupont, Laurent Vecellio, Bertrand Delaisi, Ania Carsin, Jean-Christophe Dubus
PURPOSE OF THE STUDY: Vibrating-mesh nebulizers are widely used at home for cystic fibrosis (CF) treatment, with a therapeutic efficiency closely linked to the mesh performance. This national study looks at the maintenance at home by CF patients and their families of the mesh of the eFlow(®)rapid nebulizer. Ninety-two patients from 34 French CF centers, treated at home with inhaled drugs delivered with a vibrating-mesh nebulizer, answered to a phone standardized questionnaire specifying the different techniques of maintenance of the nebulizer...
March 14, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28270542/effects-of-heat-and-moisture-exchangers-and-exhaled-humidity-on-aerosol-deposition-in-a-simulated-ventilator-dependent-adult-lung-model
#2
Arzu Ari, Khalid S Alwadeai, James B Fink
BACKGROUND: Many in vitro models report higher inhaled dose with dry versus heated humidity. Heat-and-moisture exchangers (HMEs) provide passive humidity in ventilator-dependent patients but act as a barrier to aerosol. The HMEs designed to allow aerosol delivery (HME-ADs) have not been well described. The purpose of this study is to determine the impact on aerosol deposition of HME-ADs with and without active exhaled humidity in a simulated ventilator-dependent adult model. METHODS: We used an in vitro lung model consisting of an intubated teaching mannequin with an endotracheal tube of 8...
March 7, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28248714/nebulization-of-antiinfective-agents-in-invasively-mechanically-ventilated-adults-a-systematic-review-and-meta-analysis
#3
Candela Solé-Lleonart, Jean-Jacques Rouby, Stijn Blot, Garyfallia Poulakou, Jean Chastre, Lucy B Palmer, Matteo Bassetti, Charles-Edouard Luyt, Jose M Pereira, Jordi Riera, Tim Felton, Jayesh Dhanani, Tobias Welte, Jose M Garcia-Alamino, Jason A Roberts, Jordi Rello
BACKGROUND: Nebulization of antiinfective agents is a common but unstandardized practice in critically ill patients. METHODS: A systematic review of 1,435 studies was performed in adults receiving invasive mechanical ventilation. Two different administration strategies (adjunctive and substitute) were considered clinically relevant. Inclusion was restricted to studies using jet, ultrasonic, and vibrating-mesh nebulizers. Studies involving children, colonized-but-not-infected adults, and cystic fibrosis patients were excluded...
March 1, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28203110/variability-in-delivered-dose-and-respirable-delivered-dose-from-nebulizers-are-current-regulatory-testing-guidelines-sufficient-to-produce-meaningful-information
#4
Ross Hm Hatley, Sarah M Byrne
BACKGROUND: To improve convenience to patients, there have been advances in the operation of nebulizers, resulting in fast treatment times and less drug lost to the environment. However, limited attention has been paid to the effects of these developments on the delivered dose (DD) and respirable delivered dose (RDD). Published pharmacopoeia and ISO testing guidelines for adult-use testing utilize a single breathing pattern, which may not be sufficient to enable effective comparisons between the devices...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28075194/aerosol-drug-delivery-during-noninvasive-positive-pressure-ventilation-effects-of-intersubject-variability-and-excipient-enhanced-growth
#5
Ross L Walenga, P Worth Longest, Anubhav Kaviratna, Michael Hindle
BACKGROUND: Nebulized aerosol drug delivery during the administration of noninvasive positive pressure ventilation (NPPV) is commonly implemented. While studies have shown improved patient outcomes for this therapeutic approach, aerosol delivery efficiency is reported to be low with high variability in lung-deposited dose. Excipient enhanced growth (EEG) aerosol delivery is a newly proposed technique that may improve drug delivery efficiency and reduce intersubject aerosol delivery variability when coupled with NPPV...
January 11, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28073994/vibrating-mesh-nebulizer-compared-with-metered-dose-inhaler-in-mechanically-ventilated-subjects
#6
Meagan N Dubosky, Yi-Fan Chen, Mary E Henriksen, David L Vines
BACKGROUND: The impact of various aerosol delivery devices on patient outcomes during mechanical ventilation is unknown. If one method of delivery results in a higher ventilator-associated pneumonia (VAP) rate than another, multiple patient outcomes may be affected. This study aimed to determine whether there was a difference in VAP occurrence and patient outcomes (days receiving ventilation and in-hospital mortality) between the vibrating mesh nebulizer (AeroNeb Solo) and the metered-dose inhaler (MDI)...
January 10, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28003554/reliability-of-vibrating-mesh-technology
#7
Ashwin A Gowda, Ann D Cuccia, Gerald C Smaldone
BACKGROUND: For delivery of inhaled aerosols, vibrating mesh systems are more efficient than jet nebulizers are and do not require added gas flow. We assessed the reliability of a vibrating mesh nebulizer (Aerogen Solo, Aerogen Ltd, Galway Ireland) suitable for use in mechanical ventilation. METHODS: An initial observational study was performed with 6 nebulizers to determine run time and efficiency using normal saline and distilled water. Nebulizers were run until cessation of aerosol production was noted, with residual volume and run time recorded...
January 2017: Respiratory Care
https://www.readbyqxmd.com/read/27977306/nasal-and-olfactory-deposition-with-normal-and-bidirectional-intranasal-delivery-techniques-in-vitro-tests-and-numerical-simulations
#8
Jinxiang Xi, Zhaoxuan Wang, Danielle Nevorski, Thomas White, Yue Zhou
BACKGROUND: Intranasal delivery protocols that can effectively deposit drugs to the olfactory region are severely lacking. Furthermore, it is still challenging to quantify nasal deposition on a regional or local basis, which is crucial in assessing the performance of targeted olfactory drug delivery. OBJECTIVES: To visually and quantitatively compare drug depositions in the nose and olfactory region with normal and bidirectional breathing patterns with vibrating mesh and jet nebulizers...
December 15, 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27822851/spect-ct-comparison-of-lung-deposition-using-a-system-combining-a-vibrating-mesh-nebulizer-with-a-valved-holding-chamber-and-a-conventional-jet-nebulizer-a-randomized-cross-over-study
#9
Jonathan Dugernier, Michel Hesse, Rita Vanbever, Virginie Depoortere, Jean Roeseler, Jean-Bernard Michotte, Pierre-François Laterre, François Jamar, Gregory Reychler
PURPOSE: To compare in vivo the total and regional pulmonary deposition of aerosol particles generated by a new system combining a vibrating-mesh nebulizer with a specific valved holding chamber and constant-output jet nebulizer connected to a corrugated tube. METHODS: Cross-over study comparing aerosol delivery to the lungs using two nebulizers in 6 healthy male subjects: a vibrating-mesh nebulizer combined with a valved holding chamber (Aerogen Ultra®, Aerogen Ltd...
November 7, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27732894/development-of-aqueous-dispersions-of-coenzyme-q10-for-pulmonary-delivery-and-the-dynamics-of-active-vibrating-mesh-aerosolization
#10
Thiago C Carvalho, John P McCook, Niven R Narain, Jason T McConville
Coenzyme Q10 (CoQ10) is a poorly-water soluble compound that is being investigated for the treatment of carcinomas. The aim of this study was to investigate the feasibility of preparing phospholipid-stabilized dispersions of the anticancer agent for continuous pulmonary delivery using a vibrating-mesh nebulizer. We determined the physicochemical properties (drug particle size distribution in dispersion, zeta potential, surface tension, and rheology) and compared the aerosolization profiles (nebulization performance, aerodynamic drug deposition and total emitted dose) of dispersions of CoQ10 prepared with different phospholipids...
December 5, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27547723/a-case-of-severe-acute-exacerbation-of-yokkaichi-asthma-treated-with-a-vibrating-mesh-nebulizer
#11
Takeshi Yano, Tetsu Yonaha, Koutaro Hidaka, Masumi Nagahama, Tomohiro Koshida, Hiroshi Matsuoka, Masahiko Taniguchi, Isao Tsuneyoshi
Yokkaichi asthma was one of the most common environmental pollution diseases in Japan in the 1960s and 1970s. The problem of air pollution in Yokkaichi was solved in the 1970s. However, mortality and life expectancy were still affected by the late effects of air pollution in patients with Yokkaichi asthma even in the 2000s. In this case report, we described the experience of successful treatment of a patient with severe asthmatic status due to Yokkaichi asthma. A 40s-year-old man, who was officially certified as a patient with Yokkaichi asthma from his infancy, was admitted to hospital due to acute exacerbation of asthma...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27493018/in-vitro-aerodynamic-characteristics-of-aerosol-delivered-from-different-inhalation-methods-in-mechanical-ventilation
#12
Muhammad H E ElHansy, Marina E Boules, Heba Farid, Henry Chrystyn, Sameh Kamal El-Maraghi, Mohamed Bakry Al-Kholy, Assem Fouad Mohamed El-Essawy, Maha M Abdelrahman, Amira S A Said, Raghda R S Hussein, Hoda Rabea, Mohamed E A Abdelrahim
Aerodynamic characteristics of aerosol delivery during invasive mechanical ventilation (IMV) are mostly determined by inserting cascade impactor in the circuit. Impactor might have some effect on airflow within IMV. Hence, the aim of the present study was to develop and evaluate new in vitro aerodynamic characterization methodology without affecting airflow in IMV. Breathing simulator was set in standard adult IMV circuit with inspiratory and expiratory pressures of 20 and 5 cm H2O, 1:3 inspiratory-expiratory ratio, 15 breaths min(-1), and tidal volume of 500 ml...
August 30, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27447788/aerosol-delivery-with-two-ventilation-modes-during-mechanical-ventilation-a-randomized-study
#13
Jonathan Dugernier, Gregory Reychler, Xavier Wittebole, Jean Roeseler, Virginie Depoortere, Thierry Sottiaux, Jean-Bernard Michotte, Rita Vanbever, Thierry Dugernier, Pierre Goffette, Marie-Agnes Docquier, Christian Raftopoulos, Philippe Hantson, François Jamar, Pierre-François Laterre
BACKGROUND: Volume-controlled ventilation has been suggested to optimize lung deposition during nebulization although promoting spontaneous ventilation is targeted to avoid ventilator-induced diaphragmatic dysfunction. Comparing topographic aerosol lung deposition during volume-controlled ventilation and spontaneous ventilation in pressure support has never been performed. The aim of this study was to compare lung deposition of a radiolabeled aerosol generated with a vibrating-mesh nebulizer during invasive mechanical ventilation, with two modes: pressure support ventilation and volume-controlled ventilation...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27392199/nasal-high-flow-nebulization-in-infants-and-toddlers-an-in-vitro-and-in-vivo-scintigraphic-study
#14
François Réminiac, Laurent Vecellio, Ronan Mac Loughlin, Deborah Le Pennec, Maria Cabrera, Nathalie Heuzé Vourc'h, James B Fink, Stephan Ehrmann
Aerosol therapy in infants and toddlers is challenging. Nebulization within a nasal high flow (NHF) circuit is attractive. The aim of this study was to quantify aerosol lung deposition when combined with NHF as compared with standard practice. Lung doses were measured scintigraphically after nebulization with jet and mesh nebulizer placed within a NHF circuit in a spontaneously breathing non-human primate model (macaque) and in the anatomical bench SAINT model, respectively representing a full-term newborn and a 9-month-old toddler...
July 8, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27371808/creation-of-a-protective-pulmonary-bioshield-against-inhaled-organophosphates-using-an-aerosolized-bioscavenger
#15
Yvonne J Rosenberg, James B Fink
In addition to the global use of organophosphate (OP) pesticides for agriculture, OP nerve agents and pesticides have been employed on battlefields and by terrorists (e.g., a recent sarin attack in Syria). These occurrences highlight the need for an effective countermeasure against OP exposure. Human butyrylcholinesterase (HuBChE) is a leading candidate, but injection of the high doses required for protection present pharmacokinetic challenges. An aerosolized recombinant form (aer-rHuBChE) that can neutralize inhaled OPs at the portal of entry has been assessed for its efficacy in protecting macaques against respiratory toxicity following inhalation exposure to the pesticide paraoxon (aer-Px)...
June 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27351427/inhaled-pyrazinoic-acid-esters-for-the-treatment-of-tuberculosis
#16
E F Young, E Perkowski, S Malik, J D Hayden, P G Durham, L Zhong, J T Welch, Miriam S Braunstein, Anthony J Hickey
PURPOSE: Analog development of existing drugs and direct drug delivery to the lungs by inhalation as treatments for multiple and extensively drug resistant (MDR and XDR) tuberculosis (TB) represent new therapeutic strategies. Pyrazinamide (PZA) is critical to drug sensitive TB therapy and is included in regimens for MDR TB. However, PZA-resistant Mycobacterium tuberculosis (Mtb) strains threaten its use. Pyrazinoic acid esters (PAEs) are PZA analogs effective against Mtb in vitro, including against the most common PZA resistant strains...
October 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27310926/in-vitro-comparison-of-a-vibrating-mesh-nebulizer-operating-in-inspiratory-synchronized-and-continuous-nebulization-modes-during-noninvasive-ventilation
#17
Jean-Bernard Michotte, Enrico Staderini, Deborah Le Pennec, Jonathan Dugernier, Rares Rusu, Jean Roeseler, Laurent Vecellio, Giuseppe Liistro, Grégory Reychler
UNLABELLED: Backround: Coupling nebulization with noninvasive ventilation (NIV) has been shown to be effective in patients with respiratory diseases. However, a breath-synchronized nebulization option that could potentially improve drug delivery by limiting drug loss during exhalation is currently not available on bilevel ventilators. The aim of this in vitro study was to compare aerosol delivery of amikacin with a vibrating mesh nebulizer coupled to a single-limb circuit bilevel ventilator, using conventional continuous (Conti-Neb) and experimental inspiratory synchronized (Inspi-Neb) nebulization modes...
2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27173943/development-of-a-drug-delivery-system-for-efficient-alveolar-delivery-of-a-neutralizing-monoclonal-antibody-to-treat-pulmonary-intoxication-to-ricin
#18
Renaud Respaud, Denis Marchand, Thibaut Pelat, Kam-Meng Tchou-Wong, Chad J Roy, Christelle Parent, Maria Cabrera, Joël Guillemain, Ronan Mac Loughlin, Eric Levacher, Alexandre Fontayne, Laurence Douziech-Eyrolles, Alexandra Junqua-Moullet, Laurent Guilleminault, Philippe Thullier, Emmanuelle Guillot-Combe, Laurent Vecellio, Nathalie Heuzé-Vourc'h
The high toxicity of ricin and its ease of production have made it a major bioterrorism threat worldwide. There is however no efficient and approved treatment for poisoning by ricin inhalation, although there have been major improvements in diagnosis and therapeutic strategies. We describe the development of an anti-ricin neutralizing monoclonal antibody (IgG 43RCA-G1) and a device for its rapid and effective delivery into the lungs for an application in humans. The antibody is a full-length IgG and binds to the ricin A-chain subunit with a high affinity (KD=53pM)...
July 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27162615/iloprost-drug-delivery-during-infant-conventional-and-high-frequency-oscillatory-ventilation
#19
Robert M DiBlasi, Dave N Crotwell, Shuijie Shen, Jiang Zheng, James B Fink, Delphine Yung
Iloprost is a selective pulmonary vasodilator approved for inhalation by the Food and Drug Administration. Iloprost has been increasingly used in the management of critically ill neonates with hypoxic lung disease. This in vitro study was designed to test the hypothesis that aerosol drug delivery could be effectively administered to infants with both conventional ventilation and high-frequency oscillatory ventilation (HFOV). A neonatal test lung model configured with newborn lung mechanics was ventilated with a conventional ventilator and an HFOV with standard settings...
March 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/27061412/the-function-and-performance-of-aqueous-aerosol-devices-for-inhalation-therapy
#20
REVIEW
Thiago C Carvalho, Jason T McConville
OBJECTIVES: In this review paper, we explore the interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations for several types of devices, namely jet, ultrasonic and vibrating-mesh nebulizers; colliding and extruded jets; electrohydrodynamic mechanism; surface acoustic wave microfluidic atomization; and capillary aerosol generation. KEY FINDINGS: Nebulization is the transformation of bulk liquids into droplets...
May 2016: Journal of Pharmacy and Pharmacology
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