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https://www.readbyqxmd.com/read/29679925/tocotrienol-rich-fraction-supplementation-reduces-hyperglycemia-induced-skeletal-muscle-damage-through-regulation-of-insulin-signaling-and-oxidative-stress-in-type-2-diabetic-mice
#1
Heaji Lee, Yunsook Lim
Chronic hyperglycemia induces impairment of muscle growth and development of diabetes mellitus (DM). Since skeletal muscle is the major site for disposal of ingested glucose, impaired glucose metabolism causes imbalance between protein synthesis and degradation which adversely affects physical mobility. In this study, we investigated the effect of tocotrienol-rich fraction (TRF) supplementation on skeletal muscle damage in diabetic mice. Diabetes was induced by a high-fat diet with streptozotocin (STZ) injection (100 mg/kg) in male C57BL/6J mice...
March 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29679624/perspectives-on-diagnostic-strategies-for-hyperglycemia-in-pregnancy-dealing-with-the-barriers-and-challenges-in-china
#2
Yumei Wei, Huixia Yang
Hyperglycemia is one of the most common medical conditions women encounter during pregnancy. Hyperglycemia in pregnancy (HIP) is an issue of increasing concern to both obstetricians and administrators and it brings health issues for both mothers and offspring, not only early complications, but also long-term effects. HIP may either have been pre-gestational diabetes mellitus (pGDM), or gestational diabetes mellitus (GDM). After two-child policy fully carried out in China, the incidence of HIP would be increased further...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679542/treatments-for-diabetes-mellitus-type-ii-new-perspectives-regarding-the-possible-role-of-calcium-and-camp-interaction
#3
REVIEW
Diego Soares Carvalho, Alexandre Aparecido de Almeida, Aurélio Ferreira Borges, Diego Vannucci Campos
Diabetes mellitus (DM) is among the top ten causes of death worldwide. It is considered to be one of the major global epidemics of the 21st century, with a significant impact on public health budgets. DM is a metabolic disorder with multiple etiologies. Its pathophysiology is marked by dysfunction of pancreatic β-cells which compromises the synthesis and secretion of insulin along with resistance to insulin action in peripheral tissues (muscle and adipose). Subjects presenting insulin resistance in DM type 2 often also exhibit increased insulin secretion and hyperinsulinemia...
April 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29679254/metformin-reduces-the-relapse-rate-of-tuberculosis-patients-with-diabetes-mellitus-experiences-from-3-year-follow-up
#4
Y Ma, Y Pang, W Shu, Y-H Liu, Q-P Ge, J Du, L Li, W-W Gao
The role of metformin (MET) on treatment effect of diabetic tuberculosis (TB) patients has not been studied in China. Thus, we conducted a retrospective study to investigate whether MET exhibited more efficacy in combination with anti-TB regimens for diabetic TB patients. All patients recruited came from five tuberculosis control and prevention institutes from July 2009 to July 2016 and completed 3 years of follow-up. We used chi-square test or Fisher's exact test to evaluate the demographic characteristics and the frequency of clinical outcome between MET and non-MET group...
April 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29679246/reliability-of-tensiomyography-and-myotonometry-in-detecting-mechanical-and-contractile-characteristics-of-the-lumbar-erector-spinae-in-healthy-volunteers
#5
Christine Lohr, Klaus-Michael Braumann, Ruediger Reer, Jan Schroeder, Tobias Schmidt
PURPOSE: Tensiomyography™ (TMG) and MyotonPRO® (MMT) are two non-invasive devices for monitoring muscle contractile and mechanical characteristics. This study aimed to evaluate the test-retest reliability of TMG and MMT parameters for measuring (TMG:) muscle displacement (Dm ), contraction time (Tc ), and velocity (Vc ) and (MMT:) frequency (F), stiffness (S), and decrement (D) of the erector spinae muscles (ES) in healthy adults. A particular focus was set on the establishment of reliability measures for the previously barely evaluated secondary TMG parameter Vc ...
April 20, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29679113/increased-evidence-for-the-prognostic-value-of-fdg-uptake-on-late-treatment-pet-in-non-tumour-affected-oesophagus-in-irradiated-patients-with-oesophageal-carcinoma
#6
Yimin Li, Frank Hofheinz, Christian Furth, Chen Lili, Wu Hua, Pirus Ghadjar, Sebastian Zschaeck
PURPOSE: 18 F-FDG uptake in irradiated non-tumour-affected oesophagus (NTO) on restaging PET is a potential surrogate for the measurement of radiation-induced inflammation. Radiation-induced inflammation itself has been shown to be of high prognostic relevance in patients undergoing preoperative radiochemotherapy (RCT) for locally advanced oesophageal cancer. We assessed the prognostic relevance of FDG uptake in the NTO in an independent cohort of patients treated with definitive RCT...
April 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29678866/gaps-in-guidelines-for-the-management-of-diabetes-in-low-and-middle-income-versus-high-income-countries-a-systematic-review
#7
REVIEW
Mayowa O Owolabi, Joseph O Yaria, Meena Daivadanam, Akintomiwa I Makanjuola, Gary Parker, Brian Oldenburg, Rajesh Vedanthan, Shane Norris, Ayodele R Oguntoye, Morenike A Osundina, Omarys Herasme, Sulaiman Lakoh, Luqman O Ogunjimi, Sarah E Abraham, Paul Olowoyo, Carolyn Jenkins, Wuwei Feng, Hernán Bayona, Sailesh Mohan, Rohina Joshi, Ruth Webster, Andre P Kengne, Antigona Trofor, Lucia Maria Lotrean, Devarsetty Praveen, Jessica H Zafra-Tanaka, Maria Lazo-Porras, Kirsten Bobrow, Michaela A Riddell, Konstantinos Makrilakis, Yannis Manios, Bruce Ovbiagele
OBJECTIVE: The extent to which diabetes (DM) practice guidelines, often based on evidence from high-income countries (HIC), can be implemented to improve outcomes in low- and middle-income countries (LMIC) is a critical challenge. We carried out a systematic review to compare type 2 DM guidelines in individual LMIC versus HIC over the past decade to identify aspects that could be improved to facilitate implementation. RESEARCH DESIGN AND METHODS: Eligible guidelines were sought from online databases and websites of diabetes associations and ministries of health...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29678605/hypoglycemia-in-type-2-dm-patients-review-article
#8
REVIEW
Ayla M Tourkmani, Turki J Alharbi, Abdulaziz M Bin Rsheed, Abdulrhamn N AlRasheed, Saad M AlBattal, Osama Abdelhay, Mohamed A Hassali, Alian A Alrasheedy, Nouf G Al Harbi, Abdulaziz Alqahtani
Hypoglycemia is an essential issue for diabetic patients and considered a limiting factor in the glycemic management. Heterogeneity of the diseases in Type 2 Diabetes Mellitus can affect the frequency of hypoglycemia, especially when the patient has cardiovascular diseases. There are several factors lead to hypoglycemia sulfonylurea therapy, insulin therapy, delayed or missed a meal, physical exercise, or drug or alcohol consumption. Long-term studies reported that repeated hypoglycemia is increasing the risk of cardiovascular disease...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678169/omega-3-polyunsaturated-fatty-acid-attenuates-the-inflammatory-response-by-modulating-microglia-polarization-through-sirt1-mediated-deacetylation-of-the-hmgb1-nf-%C3%AE%C2%BAb-pathway-following-experimental-traumatic-brain-injury
#9
Xiangrong Chen, Chunnuan Chen, Sining Fan, Shukai Wu, Fuxing Yang, Zhongning Fang, Huangde Fu, Yasong Li
BACKGROUND: Microglial polarization and the subsequent neuroinflammatory response are contributing factors for traumatic brain injury (TBI)-induced secondary injury. High mobile group box 1 (HMGB1) mediates the activation of the NF-κB pathway, and it is considered to be pivotal in the late neuroinflammatory response. Activation of the HMGB1/NF-κB pathway is closely related to HMGB1 acetylation, which is regulated by the sirtuin (SIRT) family of proteins. Omega-3 polyunsaturated fatty acids (ω-3 PUFA) are known to have antioxidative and anti-inflammatory effects...
April 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29677533/proresolving-protein-annexin-a1-the-role-in-type-2-diabetes-mellitus-and-obesity
#10
Nathalia T Pietrani, Cláudia N Ferreira, Kathryna F Rodrigues, Luiza O Perucci, Fernanda S Carneiro, Adriana A Bosco, Marina C Oliveira, Solange S Pereira, Antônio L Teixeira, Jacqueline I Alvarez-Leite, Adaliene V Ferreira, Lirlândia P Sousa, Karina B Gomes
BACKGROUND: Annexin A1 (AnxA1) is a protein involved in inflammation resolution that might be altered in obesity-associated type 2 diabetes mellitus (DM), which is a chronic inflammatory disease. The aim of this study was to evaluate AnxA1 serum levels in individuals with and without DM stratified according to the body mass index (BMI), and the dynamic of AnxA1 expression in adipose tissue from humans with obesity and non-obesity. METHODS: Serum samples were obtained from 41 patients with DM (lean, overweight and obese) and 40 controls, and adipose tissue samples were obtained from 16 individuals with obesity (with or without DM), and 15 controls...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677375/characteristics-of-retinal-structural-and-microvascular-alterations-in-early-type-2-diabetic-patients
#11
Qi Chen, Fan Tan, Yufei Wu, Xiran Zhuang, Chaoming Wu, Yuheng Zhou, Yingzi Li, Dan Cheng, Jianhua Wang, Fan Lu, Meixiao Shen
Purpose: To investigate early retinal structural and microvascular changes in patients with type 2 diabetes mellitus (DM) and to analyze relationships among the retinal structure, microvasculature, and choroid. Methods: Seventy-seven patients with type 2 DM (40 with no diabetic retinopathy [DR], 37 with nonproliferative diabetic retinopathy [NPDR]), and 34 control subjects were enrolled. Spectral-domain optical coherence tomography, operating in radial 18-line mode, obtained macular images of the eight intraretinal layers and the choroid...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677191/type-2-diabetic-aldehyde-dehydrogenase-2-mutant-mice-aldh-2-2-exhibiting-heart-failure-with-preserved-ejection-fraction-phenotype-can-be-determined-by-exercise-stress-echocardiography
#12
Guodong Pan, Srikar Munukutla, Ananya Kar, Joseph Gardinier, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi
E487K point mutation of aldehyde dehydrogenase (ALDH) 2 (ALDH2*2) in East Asians intrinsically lowers ALDH2 activity. ALDH2*2 is associated with diabetic cardiomyopathy. Diabetic patients exhibit heart failure of preserved ejection fraction (HFpEF) i.e. while the systolic heart function is preserved in them, they may exhibit diastolic dysfunction, implying a jeopardized myocardial health. Currently, it is challenging to detect cardiac functional deterioration in diabetic mice. Stress echocardiography (echo) in the clinical set-up is a procedure used to measure cardiac reserve and impaired cardiac function in coronary artery diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29676544/clinical-implications-of-using-post-challenge-plasma-glucose-levels-for-early-diagnosis-of-type-2-diabetes-mellitus-in-older-individuals
#13
Kyong Hye Joung, Sang Hyun Ju, Ji Min Kim, Sorim Choung, Jae Min Lee, Kang Seo Park, Hyun Jin Kim, Bon Jeong Ku
BACKGROUND: The aim of this study was to explore the differences in the clinical characteristics and diagnostic rates of diabetes mellitus (DM) according to various criteria in different age groups and to evaluate the efficacy of each criterion for screening older patients. METHODS: We studied 515 patients and measured the fasting plasma glucose level (FPG), 2-hour plasma glucose level after the 75 g oral glucose tolerance test (2-hour postload glucose [2-h PG]), and glycosylated hemoglobin (HbA1c) for re-evaluation of hyperglycemia without a history of diabetes...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29675916/serum-apoa4-levels-predicted-the-progression-of-renal-impairment-in-t2dm
#14
Chao-Wen Cheng, Che-Chang Chang, Hsiu-Wen Chen, Ching-Yu Lin, Jin-Shuen Chen
BACKGROUND: Among multiple causes, diabetic nephropathy (DN) is the major underlying renal disease that leads to end-stage renal disease (ESRD), and early diagnosis can effectively prevent or delay the progression to ESRD. Therefore, the current study aimed to develop non-invasive, accurate detection markers. MATERIALS & METHODS: For this study, 62 diabetes mellitus (DM) patients, 59 DN patients, and 21 healthy controls (HCs) were recruited. All participants' serum samples were subjected to concavanalin (Con) A affinity chromatography, which utilizes glycoproteins to discover potential markers...
April 19, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29675781/strategic-supplementation-of-cassava-top-silage-to-enhance-rumen-fermentation-and-milk-production-in-lactating-dairy-cows-in-the-tropics
#15
Metha Wanapat, Kampanat Phesatcha, Bounnaxay Viennasay, Burarat Phesatcha, Thiwakorn Ampapon, Sungchhang Kang
High-quality protein roughage is an important feed for productive ruminants. This study examined the effects of strategic feeding of lactating cows with cassava (Manihot esculenta) top silage (CTS) on rumen fermentation, feed intake, milk yield, and quality. Four early lactating crossbred dairy cows (75% Holstein-Friesian and 25% Thai) with body weight (BW) 410 ± 30 kg and milk yield 12 ± 2 kg/day were randomly allotted in a 4 × 4 Latin square design to four different supplementation levels of CTS namely, 0, 0...
April 19, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29675479/associations-of-diabetic-retinopathy-with-retinal-neurodegeneration-on-the-background-of-diabetes-mellitus-overview-of-recent-medical-studies-with-an-assessment-of-the-impact-on-healthcare-systems
#16
Rafał Muc, Agnieszka Saracen, Iwona Grabska-Liberek
Diabetes Mellitus (DM) is one of the biggest healthcare and financial problems worldwide. The disease is strongly associated with microvascular and macrovascular complications, causing co-existing diseases like Diabetic Retinopathy, Diabetic Neuropathy and Diabetic Nephropathy. Annual healthcare expenditures for diabetes treatment and complications prevention cost 727 billion USD in year 2017. Diabetes Mellitus, Diabetic Retinopathy and Diabetic Retinal Neuropathy are closely related diseases - originating from incorrectly controlled glycemia, blood pressure and lipid levels in the course of increasing resistance of the body tissues to insulin...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29674847/good-function-and-high-patient-satisfaction-at-mean-2-8-years-after-dual-mobility-tha-following-femoral-neck-fracture-a-cross-sectional-study-of-124-patients
#17
Steffan Tabori-Jensen, Torben B Hansen, Søren Bøvling, Peter Aalund, Morten Homilius, Maiken Stilling
Aims: Our aim was to investigate function, health status and satisfaction in patients treated with primary dual mobility (DM) total hip arthroplasty (THA) after displaced femoral neck fracture (FNF). Patients and methods: From 2005-2011, 414 consecutive FNF patients received Saturne DM THA. At a minimum of 1-year follow-up, 124 (95 women) were evaluated with Oxford Hip Score (OHS), Harris Hip Score (HHS), health-related quality of life (HRQoL) measure (EQ-5D) and two functional tests: Timed Up and Go (TUG) and Sit to Stand 10 times (STS)...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29673846/estimating-hba1c-from-timed-self-monitored-blood-glucose-values
#18
WuQiang Fan, Hui Zheng, Nancy Wei, David M Nathan
AIMS: To analyze mathematical relationships between timed Self-Monitored Blood Glucose (SMBG) and HbA1c, and to identify the SMBG values that correlate most strongly with HbA1c. METHODS: We utilized the average premeal (Pre) and 90-min postmeal (Post) SMBG results from 547 A1c-Derived Average Glucose (ADAG) study participants (285 type 1, 178 type 2 and 84 non-diabetic) to analyze the mathematical relationships with HbA1c levels. Specific times of daily SMBG that best correlate with HbA1c were identified...
April 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29673808/differences-in-recurrence-and-survival-of-extremity-liposarcoma-subtypes
#19
M Vos, H Koseła-Paterczyk, P Rutkowski, G J L H van Leenders, M Normantowicz, A Lecyk, S Sleijfer, C Verhoef, D J Grünhagen
BACKGROUND: Liposarcomas can be divided into four subtypes and are most frequently located in the extremities. There are currently no studies comparing the clinical outcomes, such as local recurrence and distant metastasis, between the distinct subtypes of primary LPS of the extremity specifically. METHODS: Retrospective databases of two expertise centres (Rotterdam-R, Warsaw-W) of patients with liposarcoma located in the extremities from 1985 to 2015 were used to analyse 5-year local recurrence-free survival (5y-LRFS), 5-year distant metastasis-free survival (5y-DMFS) and 5-year overall survival (5y-OS)...
April 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29673333/protocol-for-the-chord-project-community-health-outreach-to-reduce-diabetes-a-cluster-randomized-community-health-worker-trial-to-prevent-diabetes
#20
Nadia Islam, Thomas Gepts, Isaac Lief, Radhika Gore, Natalie Levy, Michael Tanner, Yixin Fang, Scott E Sherman, Mark D Schwartz
BACKGROUND: Type 2 diabetes mellitus (DM) affects 9.4% of US adults and children, while another 33.9% of Americans are at risk of DM. Health care institutions face many barriers to systematically delivering the preventive care needed to decrease DM incidence. Community health workers (CHWs) may, as frontline public health workers bridging clinic and community, help overcome these challenges. This paper presents the protocol for a pragmatic, cluster-randomized trial integrating CHWs into two primary care clinics to support DM prevention for at-risk patients...
April 19, 2018: BMC Public Health
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