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https://www.readbyqxmd.com/read/28337076/nebulized-gentamicin-as-an-alternative-to-nebulized-tobramycin-for-tracheitis-in-pediatric-patients
#1
Justin K Chen, Brittany L Martin-McNew, Lisa M Lubsch
OBJECTIVES: Tracheitis is an infection of the lower respiratory tract and is defined by the US Centers for Disease Control and Prevention (CDC) based on signs and symptoms with no radiographic evidence of pneumonia. One method of treatment involves the use of tobramycin given by nebulizer. The purpose of this study was to compare the safety and efficacy of nebulized gentamicin with nebulized tobramycin. METHODS: This study was conducted in patients under 21 years of age who received greater than or equal to 1 day of gentamicin, 80 mg, or tobramycin, 300 mg, given twice a day by nebulization within the 14-month study period...
January 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28325776/noninvasive-respiratory-support-during-pediatric-ground-transport-implementation-of-a-safe-and-feasible-procedure
#2
Nuria Millán, Carme Alejandre, Aina Martinez-Planas, Josep Caritg, Elisabeth Esteban, Martí Pons-Òdena
BACKGROUND: The purpose of this work was to determine the safety and feasibility of noninvasive support in children with acute respiratory failure (ARF) during interhospital ground transport. METHODS: This was a prospective, single-center observational clinical study in the pediatric transport unit of a tertiary-care pediatric hospital. We included all subjects with ARF transported from November 2010 to March 2013. A specific noninvasive support protocol was used for all cases...
March 21, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28325181/inhalation-therapy-in-horses
#3
REVIEW
Mandy L Cha, Lais R R Costa
This article discusses the benefits and limitations of inhalation therapy in horses. Inhalation drug therapy delivers the drug directly to the airways, thereby achieving maximal drug concentrations at the target site. Inhalation therapy has the additional advantage of decreasing systemic side effects. Inhalation therapy in horses is delivered by the use of nebulizers or pressured metered dose inhalers. It also requires the use of a muzzle or nasal mask in horses. Drugs most commonly delivered through inhalation drug therapy in horses include bronchodilators, antiinflammatories, and antimicrobials...
April 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/28321811/interleukin-2-old-and-new-approaches-to-enhance-immune-therapeutic-efficacy
#4
Pooja Dhupkar, Nancy Gordon
Interleukin-2 (IL-2) is a very well-known cytokine that has been studied for the past 35 years. It plays a major role in the growth and proliferation of many immune cells such NK and T cells. It is an important immunotherapy cytokine for the treatment of various diseases including cancer. Systemic delivery of IL-2 has shown clinical benefit in renal cell carcinoma and melanoma patients. However, its use has been limited by the numerous toxicities encountered with the systemic delivery. Intravenous IL-2 causes the well-known "capillary leak syndrome," or the leakage of fluid from the circulatory system to the interstitial space resulting in hypotension (low blood pressure), edema, and dyspnea that can lead to circulatory shock and eventually cardiopulmonary collapse and multiple organ failure...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28316464/peritoneal-nebulization-of-ropivacaine-during-laparoscopic-cholecystectomy-dose-finding-and-pharmacokinetic-study
#5
Massimo Allegri, Martina Ornaghi, Catherine E Ferland, Dario Bugada, Yash Meghani, Serena Calcinati, Manuela De Gregori, Federica Lovisari, Krishnaprabha Radhakrishnan, Maria Cusato, Stefano Scalia Catenacci, Marta Somaini, Guido Fanelli, Pablo Ingelmo
Background. Intraperitoneal nebulization of ropivacaine reduces postoperative pain and morphine consumption after laparoscopic surgery. The aim of this multicenter double-blind randomized controlled trial was to assess the efficacy of different doses and dose-related absorption of ropivacaine when nebulized in the peritoneal cavity during laparoscopic cholecystectomy. Methods. Patients were randomized to receive 50, 100, or 150 mg of ropivacaine 1% by peritoneal nebulization through a nebulizer. Morphine consumption, pain intensity in the abdomen, wound and shoulder, time to unassisted ambulation, discharge time, and adverse effects were collected during the first 48 hours after surgery...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28315491/vibrating-mesh-nebulizer-maintenance-by-cf-patients-results-from-a-french-survey
#6
Melisande Baravalle-Einaudi, Nadine Dufeu, Christian Dupont, Laurent Vecellio, Bertrand Delaisi, Ania Carsin, Jean-Christophe Dubus
PURPOSE OF THE STUDY: Vibrating-mesh nebulizers are widely used at home for cystic fibrosis (CF) treatment, with a therapeutic efficiency closely linked to the mesh performance. This national study looks at the maintenance at home by CF patients and their families of the mesh of the eFlow(®)rapid nebulizer. Ninety-two patients from 34 French CF centers, treated at home with inhaled drugs delivered with a vibrating-mesh nebulizer, answered to a phone standardized questionnaire specifying the different techniques of maintenance of the nebulizer...
March 14, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28306727/biodistribution-and-pet-imaging-of-pharmacokinetics-of-manganese-in-mice-using-manganese-52
#7
A Lake Wooten, Tolulope A Aweda, Benjamin C Lewis, Rebecca B Gross, Suzanne E Lapi
Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet; however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to manganism. Although imaging of large amounts of accumulated Mn(II) is possible by MRI, quantitative measurement of the biodistribution of manganese, particularly at the trace level, can be challenging. In this study, we produced the positron-emitting radionuclide 52Mn (t1/2 = 5.6 d) by proton bombardment (Ep<15 MeV) of chromium metal, followed by solid-phase isolation by cation-exchange chromatography...
2017: PloS One
https://www.readbyqxmd.com/read/28294577/the-enigma-of-inhaled-salbutamol-and-sport-unresolved-after-45-years
#8
K D Fitch
During the past 45 years, there have been more changes on the World Anti-Doping Agency's (WADA) Prohibited List (the List) to the status of inhaled salbutamol than any other substance. With 658 athletes, 6.1% of all participating athletes approved to inhale salbutamol at the 2008 Beijing Games, it is one of the medications used most frequently by Olympic athletes. Nevertheless, since the 2008 Games, WADA has made numerous changes to inhaled salbutamol on the List including prohibiting its use, then a year later permitting it without prior notification and recommending a pharmacokinetic study if an athlete exceeds the urinary threshold of 1000 ng/mL...
March 11, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28294220/the-microfluidic-nebulator-production-of-sub-micrometer-sized-airborne-drops
#9
Esther Amstad, Frans Spaepen, Michael P Brenner, David A Weitz
Many powders employed in the food and pharmaceutical industries are produced through spray drying because it is a cost efficient process that offers control over the particle size. However, most commercially available spray-driers cannot produce drops with diameters below 1 μm, limiting the size of spray-dried particles to values above 300 nm. We recently developed a microfluidic spray-drier that can form much smaller drops than commercially available spray-driers. This is achieved through a two-step process: first, the microfluidic spray-drier operates in the dripping regime to form 100 μm diameter primary drops in air and, second, subjects them to high shear stresses due to supersonic flow of air to break them into many much smaller secondary drops...
March 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28287363/nebulized-fentanyl-for-dyspnea-in-a-hospice-patient-with-true-allergy-to-morphine-and-hydromorphone
#10
Robert G Wahler, David B Smith, Kimberly B Mulcahy
An 86-year-old white female was admitted to hospice care with lung cancer. Even with optimal medical management, she suffered from dyspnea and required opioid therapy. However, the patient had a true morphine and hydromorphone allergy. She was administered nebulized fentanyl for symptomatic relief of dyspnea with good effect and she did not experience any allergic response.
March 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28286262/intravenous-magnesium-sulfate-for-bronchiolitis-a-randomized-trial
#11
Khalid Alansari, Rafah Sayyed, Bruce L Davidson, Shahaza Al Jawala, Mohamed Ghadier
BACKGROUND: To determine if intravenous magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in bronchiolitis patients when added to supportive care METHODS: We compared a single dose of 100 mg/kg intravenous magnesium sulfate versus placebo for acute bronchiolitis. Patients received bronchodilator therapy, nebulized hypertonic saline, and 5 days of dexamethasone if there was eczema and/or a family history of asthma. Time to medical readiness for discharge was the primary efficacy outcome...
March 9, 2017: Chest
https://www.readbyqxmd.com/read/28285981/novel-budesonide-particles-for-dry-powder-inhalation-dpi-prepared-using-a-microfluidic-reactor-coupled-with-ultrasonic-spray-freeze-drying
#12
Denis Saboti, Uroš Maver, Hak-Kim Chan, Odon Planinšek
Budesonide is a potent active pharmaceutical ingredient, often administered using respiratory devices such as metered dose inhalers (MDI), nebulizers and dry powder inhalers (DPI). Inhalable drug particles are conventionally produced by crystallization followed by milling. This approach tends to generate partially amorphous materials that require post-processing to improve the formulations' stability. Other methods involve homogenization or precipitation and often require the use of stabilizers, mostly surfactants...
March 9, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28285285/systematic-review-on-efficacy-of-magnesium-intravenous-or-nebulized-for-acute-asthma-episodes-in-children-pediatric-pulmonologist-s-viewpoint
#13
Mandeep Walia
No abstract text is available yet for this article.
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28285284/systematic-review-on-efficacy-of-magnesium-intravenous-or-nebulized-for-acute-asthma-episodes-in-children-evidence-based-medicine-viewpoint
#14
Joseph L Mathew
No abstract text is available yet for this article.
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28282499/non-opioid-medications-for-the-relief-of-chronic-breathlessness-current-evidence
#15
Carlo Barbetta, David C Currow, Miriam J Johnson
To evaluate systematically randomised clinical trials investigating non-opioid medications for the management and treatment of chronic breathlessness. Areas Covered: The evidence for the role of benzodiazepines, anxiolytics, selective serotonin re-uptake inhibitors (SSRIs), tricyclic antidepressants, antihistamines, cannabinoids, nebulized furosemide and herbal-based treatments were critically reviewed. Search of the Clinical Trials Registry (Clinicaltrial.gov) identified ongoing studies expected to generate new data in the near future in several classes of non-opioid medications for their net effect on chronic breathlessness...
March 10, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28282230/nebulized-adrenaline-in-the-postoperative-management-of-brachycephalic-obstructive-airway-syndrome-in-a-pug
#16
Jenny Ellis, Elizabeth Ann Leece
Brachycephalic obstructive airway syndrome is a common problem in certain breeds, and may necessitate surgical procedures, such as rhinoplasty, palatoplasty, laryngeal sacculectomy, and/or arytenoid laryngoplasty, to improve the quality of life. However, laryngeal edema may necessitate the use of temporary tracheostomy tubes postoperatively to maintain a patent airway. This case demonstrates that administration of nebulized adrenaline in the immediate postoperative period where upper airway obstruction is life threatening can be used to reduce edema, therefore avoiding the need for tracheostomy...
March 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28277892/development-of-optimized-inhalable-gemcitabine-loaded-gelatin-nanocarriers-for-lung-cancer
#17
Susanne R Youngren-Ortiz, David B Hill, Peter R Hoffmann, Kenneth R Morris, Edward G Barrett, M Gregory Forest, Mahavir B Chougule
BACKGROUND: Aerosol delivery of chemotherapeutic nanocarriers represents a promising alternative for lung cancer therapy. This study optimized gemcitabine (Gem)-loaded gelatin nanocarriers (GNCs) cross-linked with genipin (Gem-GNCs) to evaluate their potential for nebulized lung cancer treatment. METHODS: Gem-GNCs were prepared by two-step desolvation and optimized through Taguchi design and characterized for physicochemical properties. Particle size and morphology were confirmed by scanning and transmission electron microscopy...
March 9, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28275486/comparison-of-fluticasone-propionate-with-budesonide-administered-via-nebulizer-a-randomized-controlled-trial-in-patients-with-severe-persistent-asthma
#18
Jiangtao Lin, Ping Chen, Chuntao Liu, Jian Kang, Wei Xiao, Zhengxian Chen, Huaping Tang, Xin Du, Cindy Liu, Linda Luo
BACKGROUND: This study compared the efficacy and safety of fluticasone propionate (FP) inhalation n solution with budesonide (BUD) suspension for inhalation administered via nebulizer, in Chinese adult patients with severe, persistent asthma. METHODS: This was a multicenter, randomized, active-controlled, single-blind, parallel-group study, conducted at 26 clinical sites in China. Participants were randomized 1:1 to FP nebules 1 mg twice daily or BUD 2 mg twice daily via nebulizer for 12 weeks...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28272175/nebulized-fluticasone-for-preventing-postextubation-stridor-in-intubated-children-a-randomized-double-blind-placebo-controlled-trial
#19
Pharsai Prasertsan, Duangjai Nakju, Rojjanee Lertbunrian, Marut Chantra, Nattachai Anantasit
OBJECTIVES: To evaluate the efficacy of nebulized fluticasone propionate in the prevention of postextubation stridor in children. DESIGN: Double-blind, placebo-controlled randomized clinical trial. SETTING: PICU in a tertiary referral center. PATIENTS: Children 1 month to 15 years old who underwent mechanical ventilation. INTERVENTIONS: Patients were randomly assigned into two groups after stratification based on age group receiving nebulized fluticasone 1,000 µg or normal saline solution, immediately after extubation...
March 7, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28271325/nebulization-of-rns60-a-physically-modified-saline-attenuates-the-adoptive-transfer-of-experimental-allergic-encephalomyelitis-in-mice-implications-for-multiple-sclerosis-therapy
#20
Susanta Mondal, Suresh B Rangasamy, Supurna Ghosh, Richard L Watson, Kalipada Pahan
Developing a new and effective therapeutic approach against multiple sclerosis (MS) is always an important area of research. RNS60 is a bioactive aqueous solution generated by subjecting normal saline to Taylor-Couette-Poiseuille flow under elevated oxygen pressure. Recently we have demonstrated that RNS60, administered through intraperitoneal injection, ameliorated clinical symptoms and disease progression of experimental allergic encephalomyelitis (EAE), an animal model of MS. Since the intravenous route is not preferred for treating a chronic condition, we tested if nebulization of RNS60 could attenuate the disease process of adoptively-transferred EAE in mice...
March 7, 2017: Neurochemical Research
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