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https://www.readbyqxmd.com/read/29451812/efficacy-of-nebulized-liposomal-amphotericin-b-in-the-treatment-of-abpa-in-an-hiv-hbv-co-infected-man-case-report-and-literature-review
#1
Magali Garcia, Gwénaël Le Moal, Jacques Cadranel, France Roblot, Cendrine Godet
No abstract text is available yet for this article.
February 16, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29450988/salso-bromo-iodine-thermal-water-a-nonpharmacological-alternative-treatment-for-postnasal-drip-related-cough-in-children-with-upper-respiratory-tract-infections
#2
I La Mantia, G Ciprandi, A Varricchio, F Cupido, C Andaloro
Postnasal drip (PND)-related cough is a very common symptom in patients with upper respiratory tract infections (URTIs). At present, there is not a standard treatment for postnasal drip and postnasal drip-related cough. The aim of this pilot study was to evaluate the efficacy of a specific salso-bromo-iodine thermal water containing hyaluronic acid and grapefruit seed extract (SBI-H-GSE) comparing it with a normal saline solution in children with URTIs who refer PND-related symptoms. The study was randomized, single-blind, and controlled...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29446785/effects-of-salso-bromo-iodine-thermal-water-in-children-suffering-from-otitis-media-with-effusion-a-randomized-controlled-pilot-study
#3
I La Mantia, C Andaloro
BACKGROUND: Otitis media with effusion (OME) is an ear disorder defined by the presence of fluid in the middle ear without signs or symptoms of acute infection. The aim of this randomised and controlled pilot study was to evaluate whether the treatment with a watery salsobromo- iodine solution, administered by nasal douche, could induce ear healing better than isotonic saline in children with OME. METHODS: The study was randomized, single-blind, and controlled. Study group (40 children) was treated with salso-bromo-iodine thermal water solution and Control group (40 children) was treated with isotonic saline; both compounds were administered by nasal nebulization with Rinowash nasal douche twice/day for 10 days a month for 3 consecutive months...
January 2018: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29446742/development-of-an-in-vitro-drug-delivery-efficiency-test-for-a-pulmonary-toxicokinetic-pig-study
#4
Nadine Schaefer, Ann-Katrin Kroll, Matthias W Laschke, Michael D Menger, Hans H Maurer, Markus R Meyer, Peter H Schmidt
BACKGROUND: Since their appearance on the drugs of abuse market, synthetic cannabinoids (SCs) are gaining increasing toxicological relevance. They are consumed without knowledge of their toxicokinetic (TK) and toxicodynamic properties and human studies are not allowed due to ethical reasons. A controlled animal TK study following nebulization of 4-ethylnaphthalene-1-yl-(1-pentylindole-3-yl)methanone (JWH-210), 2-(4-methoxyphenyl)-1-(1-pentyl-indole-3-yl)methanone (RCS-4) as well as Δ9-tetrahydrocannabinol (THC) to pigs should be helpful for better interpretation of analytical results in cases of misuse or poisoning...
February 14, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29445090/two-sprayer-cvd-synthesis-of-nitrogen-doped-carbon-sponge-type-nanomaterials
#5
Emilio Muñoz-Sandoval, Juan L Fajardo-Díaz, Roque Sánchez-Salas, Alejandro J Cortés-López, Florentino López-Urías
Nitrogen-doped carbon sponge-type nanostructures (N-CSTNs) containing coaxial multiwalled carbon nanotubes are synthesized at 1020 °C by using a modified chemical vapor deposition (CVD) arrangement. Here, the CVD reactor is supplied by two flows coming from two independent sprayers (called sprayer A and sprayer B). The nebulized material in each sprayer is transported by two different gases with different flow velocities. The synthesis of carbon N-CSTNs is performed using different precursors: sprayer A contains a solution composed of ethanol, thiophene and ferrocene, whereas sprayer B contains a solution of benzylamine, thiophene and ferrocene...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440887/long-term-health-related-quality-of-life-and-symptom-response-profiles-with-arformoterol-in-copd-results-from-a-52-week-trial
#6
James F Donohue, Vamsi K Bollu, Donald E Stull, Lauren M Nelson, Valerie Sl Williams, Michael D Stensland, Nicola A Hanania
Background: Symptom severity is the largest factor in determining subjective health in COPD. Symptoms (eg, chronic cough, dyspnea) are associated with decreased health-related quality of life (HRQoL). We evaluated the impact of arformoterol on HRQoL in COPD patients, measured by St George's Respiratory Questionnaire (SGRQ). Post hoc growth mixture model (GMM) analysis examined symptom response profiles. Methods: We examined data from a randomized, double-blind, parallel-group, 12-month safety trial of twice-daily nebulized arformoterol 15 µg (n=420) versus placebo (n=421)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29436138/the-incidence-of-postoperative-respiratory-complications-a-retrospective-analysis-of-cuffed-vs-uncuffed-tracheal-tubes-in-children-0-7-years-of-age
#7
Michel de Wit, Linda M Peelen, Leo van Wolfswinkel, Jurgen C de Graaff
BACKGROUND: The use of cuffed vs uncuffed endotracheal tubes in pediatric anesthesia is widely debated. This study aimed to investigate whether the use of cuffed vs uncuffed tubes is associated with an increased incidence of acute postoperative respiratory complications. METHODS: We retrospectively studied all children aged 0-7 years in which the trachea was intubated between September 28, 2006 and August 26, 2016 in a pediatric university hospital. Logistic regression analysis was performed to estimate the association between tube design (cuffed vs uncuffed) and the incidence of acute postoperative respiratory complications (stridor, wheezing, or dyspnea; desaturations ≤90%) in need of intervention (epinephrine, dexamethasone, nebulizers, supplementary oxygen, or reintubation), adjusting for potential confounders...
March 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29432139/crossover-evaluation-of-compressors-and-nebulizers-typically-used-by-cystic-fibrosis-patients
#8
Samah M Awad, Ariel Berlinski
BACKGROUND: Compressor/nebulizer units are used to deliver inhaled medications to patients with cystic fibrosis. Practitioners and parents frequently replace either the compressor or the nebulizer with a similar component from a different brand. We hypothesized that these changes could affect the compressor/nebulizer flow-pressure and aerosol characteristics. METHODS: The following compressors were studied: Pari Vios, Pulmo-Aide model 5650D, and Inspiration Elite model HS456...
February 6, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29431643/epigenetic-dysregulation-of-the-drp1-binding-partners-mid49-and-mid51-increases-mitotic-mitochondrial-fission-and-promotes-pulmonary-arterial-hypertension-mechanistic-and-therapeutic-implications
#9
Kuang-Hueih Chen, Asish Dasgupta, Jianhui Lin, Francois Potus, Sebastien Bonnet, James Iremonger, Jennifer Fu, Jeffrey Mewburn, Danchen Wu, Kimberly Dunham-Snary, Anne L Theilmann, Zhi-Cheng Jing, Charles Hindmarch, Mark L Ormiston, Allan Lawrie, Stephen L Archer
Background -Mitotic fission is increased in pulmonary arterial hypertension (PAH), a hyperproliferative, apoptosis-resistant disease. The fission mediator, dynamin related protein 1 (Drp1) must complex with adaptor proteins to cause fission. Drp1-induced fission has been therapeutically targeted in experimental PAH. Here we examine the role of two recently discovered, poorly understood, Drp1 adapter proteins, mitochondrial dynamics protein of 49 and 51 kDa (MiD49 and MiD51) in normal vascular cells and explore their dysregulation in PAH...
February 5, 2018: Circulation
https://www.readbyqxmd.com/read/29430870/mri-signals-in-the-sacroiliac-joints-of-healthy-athletes-refining-disease-thresholds-and-treatment-strategies-in-axial-spondyloarthritis
#10
EDITORIAL
Christopher Ritchlin
The inclusion of the imaging arm in the Assessment of SpondyloArthritis International Society (ASAS) Classification Criteria catalyzed a transformation in the classification, diagnosis and treatment of axial SpA (1). A majority of patients with inflammatory back pain do not demonstrate radiographic changes and some were classified as undifferentiated spondyloarthritis (SpA) based on associated clinical features. (2). This nebulous classification was confusing at best and not recognized by many clinicians. As a result, the therapeutic approach to this group of patients was not well-defined...
February 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29430453/anticoagulant-therapy-in-acute-respiratory-distress-syndrome
#11
REVIEW
Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Antonio Artigas
Acute respiratory distress syndrome (ARDS) presents a complex pathophysiology characterized by pulmonary activated coagulation and reduced fibrinolysis. Despite advances in supportive care of this syndrome, morbidity and mortality remains high, leading to the need of novel therapies to combat this disease. Focus these therapies in the inhibition of ARDS development pathophysiology is essential. Beneficial effects of anticoagulants in ARDS have been proved in preclinical and clinical trials, thanks to its anticoagulant and anti-inflammatory properties...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29428947/a-combination-of-the-aerosolized-ppar-%C3%AE-agonist-pioglitazone-and-a-synthetic-surfactant-protein-b-peptide-mimic-prevents-hyperoxia-induced-neonatal-lung-injury-in-rats
#12
Reiko Sakurai, Cindy Lee, Humphrey Shen, Alan J Waring, Frans J Walther, Virender K Rehan
BACKGROUND: Despite improvements in perinatal care, bronchopulmonary dysplasia (BPD) in extremely premature infants has not decreased. Postnatal surfactant therapy provides symptomatic relief from respiratory distress syndrome, but does not translate into a reduction in BPD. Therefore, the search for effective interventions to prevent BPD continues. OBJECTIVES: Since PPAR-γ agonists have been demonstrated to promote neonatal lung maturation and injury repair, we hypothesized that a formulation of a PPAR-γ agonist, pioglitazone (PGZ) and a synthetic lung surfactant (a surfactant protein B peptide mimic, B-YL) combined would stimulate lung maturation and block hyperoxia-induced neonatal lung injury more effectively than either modality alone...
February 9, 2018: Neonatology
https://www.readbyqxmd.com/read/29426723/topical-therapy-for-refractory-rhinosinusitis-caused-by-methicillin-resistant-staphylococcus-aureus-first-report-in-a-prospective-series
#13
Alan H Shikani, Nadim Khoueir, Mary Ann Jabra-Rizk, Henry J Shikani, Randall J Basaraba, Jeff G Leid
OBJECTIVE: The incidence of refractory chronic rhinosinusitis (CRS) associated with methicillin-resistant Staphylococcus aureus (MRSA) is rising and remains a therapeutic challenge. The goal of this study is to demonstrate the efficacy of a non-invasive topical therapy against MRSA in these patients. METHODS: Seventeen patients with refractory CRS caused by MRSA were treated with a topical therapy protocol. Treatment consisted of weekly endoscopic sinus debridement followed by intra-sinus installation of a hydroxyl-ethylcellulose gel that releases mometasone and a culture-directed antibiotic for a period of 6 weeks, along with daily nasal nebulization of mometasone with the same antibiotic and saline rinses...
February 6, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29421665/inhaled-hexadecyl-treprostinil-provides-pulmonary-vasodilator-activity-at-significantly-lower-plasma-concentrations-than-infused-treprostinil
#14
Richard W Chapman, Zhili Li, Michel R Corboz, Helena Gauani, Adam J Plaunt, Donna M Konicek, Franziska G Leifer, Charles E Laurent, Han Yin, Dany Salvail, Chad Dziak, Walter R Perkins, Vladimir Malinin
INS1009 is a long acting pulmonary vasodilator prodrug of treprostinil (TRE) that is formulated in a lipid nanoparticle for inhaled delivery by nebulization. This study examined the ability of INS1009 to inhibit vasoconstriction in the pulmonary vasculature of rats and dogs and the extent to which local activity within the lung contributes to its activity. Rats received a single dose of INS1009 by nose-only inhalation or were given a continuous intravenous (i.v.) infusion of TRE, followed by an i.v. challenge of the thromboxane mimetic pulmonary vasoconstrictor U46619 and the increase in pulmonary arterial pressure (PAP) was measured...
February 5, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29417605/efficacy-of-a-novel-neem-oil-formulation-rp03%C3%A2-to-control-the-poultry-red-mite-dermanyssus-gallinae
#15
A Camarda, N Pugliese, A Bevilacqua, E Circella, L Gradoni, D George, O Sparagano, A Giangaspero
Dermanyssus gallinae (Mesostigmata: Dermanyssidae) is the most harmful ectoparasite of laying hens, represents an occupational hazard for poultry workers, and a growing threat to medical science per se. There is increasing demand for alternative products, including plant-derived acaricides, with which to control the mite. The present study investigated the efficacy of neem oil against D. gallinae on a heavily infested commercial laying hen farm. A novel formulation of 20% neem oil, diluted from a 2400-p.p...
February 8, 2018: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/29416463/effect-of-extended-infusion-of-meropenem-and-nebulized-amikacin-on-gram-negative-multidrug-resistant-ventilator-associated-pneumonia
#16
Mona Ahmed Ammar, Waleed Abdalla
Background: Ventilator-associated pneumonia (VAP) due to multidrug-resistant organisms (MDROs) is associated with a significant mortality in the Intensive Care Unit (ICU). The aim of this study was to compare the efficacy and safety of extended infusion of meropenem and nebulized amikacin on VAP caused by Gram-negative MDRO versus intravenous (IV) meropenem and amikacin alone. Methodology: A randomized nonblinded controlled trial was performed on ninety patients with VAP...
January 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29414002/study-of-the-use-of-axial-viewed-inductively-coupled-plasma-atomic-emission-spectrometry-with-ultrasonic-nebulization-for-the-determination-of-select-elemental-impurities-in-oral-drug-products
#17
James Menoutis, Angela Parisi, Natasha Verma
In efforts to control the potential presence of heavy metals in pharmaceuticals, the United States Pharmacopeia (USP) and International Conference on Harmonization (ICH) have put forth new requirements and guidelines for their control. The new requirements and guidelines establish specific daily exposures (PDE) for 24 heavy metals/elemental impurities (EI) based upon their toxicological properties. USP General Chapter 〈233〉 provides a general reference procedure for preparing pharmaceutical samples for analysis employing microwave assisted digestion (MWAD)...
January 23, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29405052/efficient-planar-heterojunction-perovskite-solar-cells-fabricated-by-high-throughput-sheath-gas-assisted-electrospray
#18
Sunghoon Han, Hyungchae Kim, Seojun Lee, Changsoon Kim
When a perovskite precursor solution is electrosprayed using the conventional method where the nebulization of the solution is primarily governed by electrostatics, its high electrical conductivity tends to cause electrospray instabilities and thus makes high quality perovskite films very difficult to obtain. Here, we report high-throughput fabrication of efficient perovskite solar cells (PSCs) whose CH3NH3PbI3-xClx films are deposited using a sheath-gas-assisted electrospray system. Our system, based on strong pneumatic nebulization as well as high-voltage electrostatic charging of droplets, enables very stable, high-flow electrospray of small charged droplets even for the highly conductive perovskite precursor solution...
February 6, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29402664/osteopontin-may-be-a-driver-of-abdominal-aortic-aneurysm-formation
#19
S Keisin Wang, Linden A Green, Ashley R Gutwein, Alok K Gupta, Clifford M Babbey, Raghu L Motaganahalli, Andres Fajardo, Michael P Murphy
OBJECTIVE: Previous in vitro and animal studies have suggested that osteopontin (OPN), an inflammatory extracellular matrix protein, is involved in the formation and growth of abdominal aortic aneurysms (AAAs). However, the mechanism by which this occurs continues to be nebulous. The relationship between OPN and inflammation-suppressing lymphocytes present in the human AAA condition was investigated and presented herein. METHODS: Serum OPN concentrations were measured in healthy, risk factor-matched non-AAA and AAA patients by enzyme-linked immunosorbent assay (ELISA)...
February 3, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29402527/humidification-of-blow-by-oxygen-during-recovery-of-postoperative-pediatric-patients-one-unit-s-journey
#20
Suzanne Donahue, Robert M DiBlasi, Karen Thomas
PURPOSE: To examine the practice of nebulizer cool mist blow-by oxygen administered to spontaneously breathing postanesthesia care unit (PACU) pediatric patients during Phase one recovery. DESIGN: Existing evidence was evaluated. Informal benchmarking documented practices in peer organizations. An in vitro study was then conducted to simulate clinical practice and determine depth and amount of airway humidity delivery with blow-by oxygen. METHODS: Informal benchmarking information was obtained by telephone interview...
February 2, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
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