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https://www.readbyqxmd.com/read/29289789/zoledronic-acid-increases-the-prevalence-of-medication-related-osteonecrosis-of-the-jaw-in-a-dose-dependent-manner-in-rice-rats-oryzomys-palustris-with-localized-periodontitis
#1
J G Messer, J L Mendieta Calle, J M Jiron, E J Castillo, C Van Poznak, N Bhattacharyya, D B Kimmel, J I Aguirre
OBJECTIVE: Investigate role of dose/duration of zoledronic acid (ZOL), a powerful anti-resorptive (pAR), on prevalence of medication-related osteonecrosis of the jaw (MRONJ) in rice rats (Oryzomys palustris), a species with natural susceptibility to food impaction-induced localized periodontitis (FILP). We hypothesize that ZOL induces MRONJ lesions in rice rats with FILP, and that the prevalence of MRONJ rises with increasing dose and duration of ZOL treatment. METHODS: We performed a toxicology experiment with clinically-relevant doses of ZOL in female rats (N=230) fed standard (STD) rodent chow...
December 28, 2017: Bone
https://www.readbyqxmd.com/read/29275329/amino-acid-residues-in-hiv-2-reverse-transcriptase-that-restrict-the-development-of-nucleoside-analogue-resistance-through-the-excision-pathway
#2
Mar Álvarez, Maria Nevot, Jesus Mendieta, Miguel A Martinez, Luis Menéndez-Arias
Nucleoside reverse transcriptase (RT) inhibitors (NRTIs) are the backbone of current antiretroviral treatments. However, emergence of viral resistance against NRTIs is a major threat to their therapeutic effectiveness. In HIV-1, NRTI resistance-associated mutations either reduce RT-mediated incorporation of NRTI triphosphates (discrimination mechanism) or confer an ATPmediated nucleotide excision activity that removes the inhibitor from the 3'-terminus of DNA primers, enabling further primer elongation (excision mechanism)...
December 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29220818/reuse-of-sustainable-materials-for-xylenol-orange-dye-and-copper-ii-ion-ammoniacal-removal
#3
M I Garrudo-Guirado, A Blanco-Flores, H P Toledo-Jaldin, V Sánchez-Mendieta, A R Vilchis-Néstor
Water pollution caused by heavy metals and organic compounds is an environmental problem with negative impact, making the restoration of water quality a priority. In this paper, the adsorption of xylenol orange dye (XO) on vitreous tuff mineral (VT) was studied. It was established that the adsorption capacity of VT was 45.17 mg/g. The removal was carried out by interactions between active sites on the surface of the material and the functional groups of the dye. The solid waste obtained from this process (VTXO) was reused as adsorbent material for Cu removal in the form of the complex Cu-NH3 because this process was done in an ammoniacal medium...
December 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29189179/computational-study-of-the-binding-modes-of-diverse-dpn-analogues-on-estrogen-receptors-er-and-the-biological-evaluation-of-a-new-potential-antiestrogenic-ligand
#4
Marlet Martinez, Benjamin Garcia, Brenda Colin, M Bello, Berenice Prestegui, Alma Chavez, Alfonso Duenas, Jonathan Fragoso, Jessica Mendieta, Edgar Rojano, David Ordaz, Rocio Garcia, D Castillo-Bautista, Jose Correa
Estrogen (17β-estradiol) is essential for normal growth and differentiation in the mammary gland. Previous investigations have revealed that estrogen receptor alpha (ERα) plays a critical role in breast cancer. More recently, observations regarding the widespread expression of ERβ-like proteins in normal and neoplastic mammary tissues have suggested that ERβ is also involved in the mentioned pathology. Design of new drugs both steroidal and nonsteroidal that target any of these receptors represents a promise to treat breast cancer...
November 29, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29185598/elements-of-the-socio-critical-paradigm-in-nursing-care-practices-an-integrative-review
#5
Silvana Ceolin, Manuelle Arias Piriz, Marjoriê da Costa Mendieta, José Siles González, Rita Maria Heck
OBJECTIVE: Analyze the evidence available in Brazilian theses on the elements of the socio-critical paradigm in the construction of knowledge and practices of nursing care. METHOD: An integrative literature review was carried out in the Theses Database of the Coordination for the Improvement of Higher Education Personnel and the Brazilian Digital Library of Theses and Dissertations. RESULTS: Of a total of 320 theses, only 19 had elements of the socio-critical paradigm in their construction, among which the use of participatory investigations stand out (especially action-research), which present interaction between the researcher and the participants, the use of data collection techniques such as focus groups and culture circles, and theoretical frameworks for analyzing the phenomena in their complexity...
November 27, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29129405/neurogenesis-and-morphological-neural-alterations-closely-related-to-amyloid-%C3%AE-peptide-25-35-induced-memory-impairment-in-male-rats
#6
Eleazar Ramírez, Liliana Mendieta, Gonzalo Flores, I Daniel Limón
Memory impairment by the Amyloid-β 25-35 (Aβ25-35) peptide in animal models has provided an understanding of the causes behind the similar deterioration that occurs in Alzheimer's disease. However, it is uncertain if a decrease of dendritic spines and neurogenesis conduces to cognitive impairment by an impairment in the retrieval of stored memory. The aim of this study was to evaluate the consequences of impairment on spatial memory caused by the administration of the Aβ25-35 peptide in the hippocampus, which is associated whit morphological changes and neurogenesis in the dentate gyrus (DG)...
November 6, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29069487/nf-%C3%AE%C2%BAb1-ikk%C3%AE%C2%B5-gene-expression-and-clinical-activity-in-patients-with-rheumatoid-arthritis
#7
Fabiola Lilí Sarmiento Salinas, Jonnathan Guadalupe Santillán Benítez, María Dolores Hernández Navarro, Hugo Mendieta Zerón
Objective: Rheumatoid arthritis (RA) is a systemic and autoimmune disorder whose primary characteristic is the chronic inflammation of joints. The objective of this study was to evaluate whether there was an association between nuclear factor kappa beta1/IKK epsilon (NF-κB1/IKKε) gene expression and clinical activity in RA. Methods: Sixty patients with RA were included in the study: 30 with clinical activity and 30 with clinical remission. NF-κB1/IKKε gene expression was performed by real-time quantitative polymerase chain reaction through relative quantification with Taqman probes...
October 23, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29063783/iron-therapy-substantially-restores-qeeg-maturational-lag-among-iron-deficient-anemic-infants
#8
Gloria A Otero, Thalía Fernández, F Bernardo Pliego-Rivero, Gustavo G Mendieta
OBJECTIVE: To use quantitative electroencephalography (qEEG) to assess the impact of iron-deficiency anemia on central nervous system maturation in the first year of life. METHOD: Twenty-five infants (3-12 months old) presenting ferropenic anemia (IDA) and 25 healthy controls (CTL1), matched by age/gender with the former, were studied in two stages. Electroencephalogram during spontaneous sleep was recorded from all participants; the fast Fourier transform was calculated to obtain absolute power (AP) and relative power (RP) qEEG measures...
October 24, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29050839/recommendations-by-the-spanish-society-of-rheumatology-on-the-use-of-biological-therapies-in-axial-spondyloarthritis
#9
Jordi Gratacós, Petra Díaz Del Campo Fontecha, Cristina Fernández-Carballido, Xavier Juanola Roura, Luis Francisco Linares Ferrando, Eugenio de Miguel Mendieta, Santiago Muñoz Fernández, Jose Luis Rosales-Alexander, Pedro Zarco Montejo, Mercedes Guerra Rodríguez, Victoria Navarro Compán
OBJECTIVE: Recent data published on biological therapy in axial spondyloarthritis (axSpA) since the last publication of the recommendations of the Spanish Society of Rheumatology (SER) has led to the generation of a review of these recommendations based on the best possible evidence. These recommendations should be a reference for rheumatologists and those involved in the treatment of patients with axSpA. METHODS: Recommendations were drawn up following a nominal group methodology and based on systematic reviews...
October 16, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29025216/assisted-salvage-of-ischemic-fasciocutaneous-flap-using-adipose-derived-mesenchymal-stem-cells-in-situ-revascularization
#10
Michael H Carstens, Mauricio Mendieta, Cecilia Pérez, Esperanza Villareal, Rodolfo Garcia
Adipose-derived mesenchymal stem cells (ASCs) have been shown to produce vascular endothelial growth factor (VEGF) and can increase perfusion in patients with critical limb ischemia. We will show that this concept can be applied to augment blood flow in zones of flap ischemia. We presented a case study of a 26-year-old man with a complex hand injury covered by a reverse radial perforator fasciocutaneous flap, which developed ischemic necrosis and was treated by debridement, transplantation of ASCs to enhance vascular support, and saline dressings...
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28928994/foxe1-mutation-screening-in-a-case-with-cleft-lip-hypothyroidism-and-thyroid-carcinoma-a-new-syndrome
#11
Hugo Mendieta-Zerón, Angélica Jiménez-Rosales, Carlos Jhovani Pérez-Amado, Silvia Jiménez-Morales
A 26-year-old woman is referred to the Internal Medicine consultation due to increases in laboratory studies associated with Papillary Thyroid Carcinoma (PTC) that was confirmed by histopathological studies. Her clinical history revealed that, at 3 months of age, she was successfully treated with surgery for cleft lip (CL) and at the age of 24 years was diagnosed with hypothyroidism. Single nucleotide polymorphisms (SNPs) in FOXE1 and its promoter regions have been associated with various etiologies related to the thyroid, including orofacial clefting, specially cleft palate (CP) and CL, hypothyroidism (HT), and thyroid cancer...
2017: Case Reports in Genetics
https://www.readbyqxmd.com/read/28901358/cadmium-1-4-cyclohexanedicarboxylato-coordination-polymers-bearing-different-di-alkyl-2-2-bipyridines-syntheses-crystal-structures-and-photoluminescence-studies
#12
Luis D Rosales-Vázquez, Víctor Sánchez-Mendieta, Alejandro Dorazco-González, Diego Martínez-Otero, Iván García-Orozco, Raúl A Morales-Luckie, Jonathan Jaramillo-Garcia, Antonio Téllez-López
Four coordination polymers have been synthesized using self-assembly solution reactions under ambient conditions, reacting Cd(ii) ions with 1,4-cyclohexanedicarboxylic acid in the presence of different 2,2'-bipyridine co-ligands: {[Cd(H2O)(e,a-cis-1,4-chdc)(2,2'-bpy)]·H2O}n (1); [Cd2(H2O)2(e,a-cis-1,4-chdc)2(4,4'-dmb)2]n (2); {[Cd(e,a-cis-1,4-chdc)(5,5'-dmb)]·H2O·CH3OH}n (3) and {[Cd(e,e-trans-1,4-chdc)(4,4'-dtbb)]·CH3OH}n (4), where 1,4-chdc = 1,4-cyclohexanedicarboxylato, 2,2'-bpy = 2,2'-bipyridine, 4,4'-dmb = 4,4'-dimethyl-2,2'-bipyridine, 5,5'-dmb = 5,5'-dimethyl-2,2'-bipyridine and 4,4'-dtbb = 4,4'-di-tert-butyl-2,2'-bipyridine...
September 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28879061/a-practical-guide-to-build-de-novo-assemblies-for-single-tissues-of-non-model-organisms-the-example-of-a-neotropical-frog
#13
Santiago Montero-Mendieta, Manfred Grabherr, Henrik Lantz, Ignacio De la Riva, Jennifer A Leonard, Matthew T Webster, Carles Vilà
Whole genome sequencing (WGS) is a very valuable resource to understand the evolutionary history of poorly known species. However, in organisms with large genomes, as most amphibians, WGS is still excessively challenging and transcriptome sequencing (RNA-seq) represents a cost-effective tool to explore genome-wide variability. Non-model organisms do not usually have a reference genome and the transcriptome must be assembled de-novo. We used RNA-seq to obtain the transcriptomic profile for Oreobates cruralis, a poorly known South American direct-developing frog...
2017: PeerJ
https://www.readbyqxmd.com/read/28818565/raw-starch-microparticles-have-immunostimulant-activity-in-mice-vaccinated-with-bcg-and-challenged-with-mycobacterium-tuberculosis
#14
Silvia Moreno-Mendieta, Jorge Barrios-Payán, Dulce Mata-Espinosa, Sergio Sánchez, Rogelio Hernández-Pando, Romina Rodríguez-Sanoja
The main challenge for vaccine development or improvement is the lack of safe adjuvants or immunostimulants that induce protective immune responses and can be used for mucosal immunization, which is a highly desirable strategy for vaccination against infectious diseases acquired by oral or intranasal routes. One promising alternative is the use of biodegradable and biocompatible polymeric microparticles. Recently, we developed an immobilization and delivery system with starch microparticles (SMPs) and a starch-binding domain (SBDtag) suitable for the mucosal administration of antigens and the induction of antigen-specific immune responses...
August 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28807651/recommendations-for-the-prescription-of-physical-exercise-for-patients-with-spondyloarthritis
#15
Mariano Tomás Flórez García, Loreto Carmona, Raquel Almodóvar, César Fernández de Las Peñas, Fernando García Pérez, M Ángeles Pérez Manzanero, José Manuel García García, Lidón Soriano Segarra, José Fernando Jiménez Díaz, Nuria Mendoza Laiz, Eugenio de Miguel Mendieta, Juan Carlos Torre Alonso, Luis Francisco Linares Ferrando, Eduardo Collantes Estévez, Jesús Sanz Sanz, Pedro Zarco Montejo
OBJECTIVE: To develop expert-based recommendations on physical activity and exercise for patients with spondyloarthritis (SpA). METHODS: Two discussion groups, one of physical therapists, rehabilitation physicians, and professionals of physical activity and sports, and another of rheumatologists interested in SpA, were held to discuss the results of a survey of rheumatologists on exercise and two focus groups with patients on barriers to exercise. Preliminary recommendations were drafted...
August 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28799821/a-review-of-palliative-and-hospice-care-in-the-context-of-islam-dying-with-faith-and-family
#16
Maximiliano Mendieta, Robert W Buckingham
BACKGROUND: By starting to understand Muslim culture, we can seek common ground with Islamic culture within the American experience and bridge opportunities for better palliative and hospice care here and in Middle Eastern countries. The United States, Canada, and Europe are education hubs for Middle Eastern students, creating an opportunity for the palliative and hospice care philosophy to gain access by proxy to populations of terminally ill patients who can benefit from end-of-life care...
November 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28783007/influence-of-the-chain-length-of-surfactant-in-the-modification-of-zeolites-and-clays-removal-of-atrazine-from-water-solutions
#17
Helen Paola Toledo-Jaldin, Alien Blanco-Flores, Víctor Sánchez-Mendieta, Osnieski Martín-Hernández
Removal potentials of a surfactant modified zeolite (SMZ) and clay (SMC) for atrazine adsorption were evaluated. Materials were modified with hexadecyl trimethyl ammonium bromide (HDTMA) and benzyl octadecyl dimethyl ammonium chloride (BODA) considering the critical miscelar concentration (CMC) of each one (0.94 and 0.041 meq/L, respectively). The influence of the surfactant was analyzed in detail, particularly the formation of surfactant layers (complete or partial) connected with the length of the surfactant tail (16 and 18 methyl groups or number of carbons in the chain)...
August 7, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28716729/study-of-new-interactions-of-glitazone-s-stereoisomers-and-the-endogenous-ligand-15d-pgj2-on-six-different-ppar-gamma-proteins
#18
Samuel Álvarez-Almazán, Martiniano Bello, Feliciano Tamay-Cach, Marlet Martínez-Archundia, Diana Alemán-González-Duhart, José Correa-Basurto, Jessica Elena Mendieta-Wejebe
Diabetes mellitus is a chronic disease characterized by hyperglycemia, insulin resistance and hyperlipidemia. Glitazones or thiazolidinediones (TZD) are drugs that act as insulin-sensitizing agents whose molecular target is the peroxisome proliferator-activated receptor gamma (PPARγ). The euglycemic action of TZD has been linked with the induction of type 4 glucose transporter. However, it has been shown that the effect of TZD depends on the specific stereoisomer that interacts with PPARγ. Therefore, this work is focused on exploring the interactions and geometry adopted by glitazone's stereoisomers and one endogenous ligand on different conformations of the six crystals of the PPARγ protein using molecular docking and molecular dynamics (MD) simulations accompanied by the MMGBSA approach...
October 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28683964/detrimental-effect-of-hypercholesterolemia-on-high-density-lipoprotein-particle-remodeling%C3%A2-in%C3%A2-pigs
#19
Teresa Padró, Judit Cubedo, Sandra Camino, Maria Teresa Béjar, Soumaya Ben-Aicha, Guiomar Mendieta, Joan Carles Escolà-Gil, Rafael Escate, Manuel Gutiérrez, Laura Casani, Lina Badimon, Gemma Vilahur
BACKGROUND: Beneficial effects of high-density lipoproteins (HDL) seem altered in patients with symptomatic cardiovascular disease. We recently demonstrated in a swine model of ischemia-reperfusion (IR) that hypercholesterolemia abolishes HDL-related cardioprotection. OBJECTIVES: This study sought to investigate, using the same animal model, whether the reported impairment of HDL cardioprotective function was associated with alterations in HDL remodeling and functionality...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28647264/mgo-based-adsorbents-for-co2-adsorption-influence-of-structural-and-textural-properties-on-the-co2-adsorption-performance
#20
Gutiérrez-Bonilla Elvira, Granados-Correa Francisco, Sánchez-Mendieta Víctor, Morales-Luckie Raúl Alberto
A series of MgO-based adsorbents were prepared through solution-combustion synthesis and ball-milling process. The prepared MgO-based powders were characterized using X-ray diffraction, scanning electron microscopy, N2 physisorption measurements, and employed as potential adsorbents for CO2 adsorption. The influence of structural and textural properties of these adsorbents over the CO2 adsorption behaviour was also investigated. The results showed that MgO-based products prepared by solution-combustion and ball-milling processes, were highly porous, fluffy, nanocrystalline structures in nature, which are unique physico-chemical properties that significantly contribute to enhance their CO2 adsorption...
July 2017: Journal of Environmental Sciences (China)
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