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https://www.readbyqxmd.com/read/28928994/foxe1-mutation-screening-in-a-case-with-cleft-lip-hypothyroidism-and-thyroid-carcinoma-a-new-syndrome
#1
Hugo Mendieta-Zerón, Angélica Jiménez-Rosales, Carlos Jhovani Pérez-Amado, Silvia Jiménez-Morales
A 26-year-old woman is referred to the Internal Medicine consultation due to increases in laboratory studies associated with Papillary Thyroid Carcinoma (PTC) that was confirmed by histopathological studies. Her clinical history revealed that, at 3 months of age, she was successfully treated with surgery for cleft lip (CL) and at the age of 24 years was diagnosed with hypothyroidism. Single nucleotide polymorphisms (SNPs) in FOXE1 and its promoter regions have been associated with various etiologies related to the thyroid, including orofacial clefting, specially cleft palate (CP) and CL, hypothyroidism (HT), and thyroid cancer...
2017: Case Reports in Genetics
https://www.readbyqxmd.com/read/28901358/cadmium-1-4-cyclohexanedicarboxylato-coordination-polymers-bearing-different-di-alkyl-2-2-bipyridines-syntheses-crystal-structures-and-photoluminescence-studies
#2
Luis D Rosales-Vázquez, Víctor Sánchez-Mendieta, Alejandro Dorazco-González, Diego Martínez-Otero, Iván García-Orozco, Raúl A Morales-Luckie, Jonathan Jaramillo-Garcia, Antonio Téllez-López
Four coordination polymers have been synthesized using self-assembly solution reactions under ambient conditions, reacting Cd(ii) ions with 1,4-cyclohexanedicarboxylic acid in the presence of different 2,2'-bipyridine co-ligands: {[Cd(H2O)(e,a-cis-1,4-chdc)(2,2'-bpy)]·H2O}n (1); [Cd2(H2O)2(e,a-cis-1,4-chdc)2(4,4'-dmb)2]n (2); {[Cd(e,a-cis-1,4-chdc)(5,5'-dmb)]·H2O·CH3OH}n (3) and {[Cd(e,e-trans-1,4-chdc)(4,4'-dtbb)]·CH3OH}n (4), where 1,4-chdc = 1,4-cyclohexanedicarboxylato, 2,2'-bpy = 2,2'-bipyridine, 4,4'-dmb = 4,4'-dimethyl-2,2'-bipyridine, 5,5'-dmb = 5,5'-dimethyl-2,2'-bipyridine and 4,4'-dtbb = 4,4'-di-tert-butyl-2,2'-bipyridine...
September 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28879061/a-practical-guide-to-build-de-novo-assemblies-for-single-tissues-of-non-model-organisms-the-example-of-a-neotropical-frog
#3
Santiago Montero-Mendieta, Manfred Grabherr, Henrik Lantz, Ignacio De la Riva, Jennifer A Leonard, Matthew T Webster, Carles Vilà
Whole genome sequencing (WGS) is a very valuable resource to understand the evolutionary history of poorly known species. However, in organisms with large genomes, as most amphibians, WGS is still excessively challenging and transcriptome sequencing (RNA-seq) represents a cost-effective tool to explore genome-wide variability. Non-model organisms do not usually have a reference genome and the transcriptome must be assembled de-novo. We used RNA-seq to obtain the transcriptomic profile for Oreobates cruralis, a poorly known South American direct-developing frog...
2017: PeerJ
https://www.readbyqxmd.com/read/28818565/raw-starch-microparticles-have-immunostimulant-activity-in-mice-vaccinated-with-bcg-and-challenged-with-mycobacterium-tuberculosis
#4
Silvia Moreno-Mendieta, Jorge Barrios-Payán, Dulce Mata-Espinosa, Sergio Sánchez, Rogelio Hernández-Pando, Romina Rodríguez-Sanoja
The main challenge for vaccine development or improvement is the lack of safe adjuvants or immunostimulants that induce protective immune responses and can be used for mucosal immunization, which is a highly desirable strategy for vaccination against infectious diseases acquired by oral or intranasal routes. One promising alternative is the use of biodegradable and biocompatible polymeric microparticles. Recently, we developed an immobilization and delivery system with starch microparticles (SMPs) and a starch-binding domain (SBDtag) suitable for the mucosal administration of antigens and the induction of antigen-specific immune responses...
August 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28807651/recommendations-for-the-prescription-of-physical-exercise-for-patients-with-spondyloarthritis
#5
Mariano Tomás Flórez García, Loreto Carmona, Raquel Almodóvar, César Fernández de Las Peñas, Fernando García Pérez, M Ángeles Pérez Manzanero, José Manuel García García, Lidón Soriano Segarra, José Fernando Jiménez Díaz, Nuria Mendoza Laiz, Eugenio de Miguel Mendieta, Juan Carlos Torre Alonso, Luis Francisco Linares Ferrando, Eduardo Collantes Estévez, Jesús Sanz Sanz, Pedro Zarco Montejo
OBJECTIVE: To develop expert-based recommendations on physical activity and exercise for patients with spondyloarthritis (SpA). METHODS: Two discussion groups, one of physical therapists, rehabilitation physicians, and professionals of physical activity and sports, and another of rheumatologists interested in SpA, were held to discuss the results of a survey of rheumatologists on exercise and two focus groups with patients on barriers to exercise. Preliminary recommendations were drafted...
August 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28799821/a-review-of-palliative-and-hospice-care-in-the-context-of-islam-dying-with-faith-and-family
#6
Maximiliano Mendieta, Robert W Buckingham
BACKGROUND: By starting to understand Muslim culture, we can seek common ground with Islamic culture within the American experience and bridge opportunities for better palliative and hospice care here and in Middle Eastern countries. The United States, Canada, and Europe are education hubs for Middle Eastern students, creating an opportunity for the palliative and hospice care philosophy to gain access by proxy to populations of terminally ill patients who can benefit from end-of-life care...
August 11, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28783007/influence-of-the-chain-length-of-surfactant-in-the-modification-of-zeolites-and-clays-removal-of-atrazine-from-water-solutions
#7
Helen Paola Toledo-Jaldin, Alien Blanco-Flores, Víctor Sánchez-Mendieta, Osnieski Martín-Hernández
Removal potentials of a surfactant modified zeolite (SMZ) and clay (SMC) for atrazine adsorption were evaluated. Materials were modified with hexadecyl trimethyl ammonium bromide (HDTMA) and benzyl octadecyl dimethyl ammonium chloride (BODA) considering the critical miscelar concentration (CMC) of each one (0.94 and 0.041 meq/L, respectively). The influence of the surfactant was analyzed in detail, particularly the formation of surfactant layers (complete or partial) connected with the length of the surfactant tail (16 and 18 methyl groups or number of carbons in the chain)...
August 7, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28716729/study-of-new-interactions-of-glitazone-s-stereoisomers-and-the-endogenous-ligand-15d-pgj2-on-six-different-ppar-gamma-proteins
#8
Samuel Álvarez-Almazán, Martiniano Bello, Feliciano Tamay-Cach, Marlet Martínez-Archundia, Diana Alemán-González-Duhart, José Correa-Basurto, Jessica Elena Mendieta-Wejebe
Diabetes mellitus is a chronic disease characterized by hyperglycemia, insulin resistance and hyperlipidemia. Glitazones or thiazolidinediones (TZD) are drugs that act as insulin-sensitizing agents whose molecular target is the peroxisome proliferator-activated receptor gamma (PPARγ). The euglycemic action of TZD has been linked with the induction of type 4 glucose transporter. However, it has been shown that the effect of TZD depends on the specific stereoisomer that interacts with PPARγ. Therefore, this work is focused on exploring the interactions and geometry adopted by glitazone's stereoisomers and one endogenous ligand on different conformations of the six crystals of the PPARγ protein using molecular docking and molecular dynamics (MD) simulations accompanied by the MMGBSA approach...
July 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28683964/detrimental-effect-of-hypercholesterolemia-on-high-density-lipoprotein-particle-remodeling%C3%A2-in%C3%A2-pigs
#9
Teresa Padró, Judit Cubedo, Sandra Camino, Maria Teresa Béjar, Soumaya Ben-Aicha, Guiomar Mendieta, Joan Carles Escolà-Gil, Rafael Escate, Manuel Gutiérrez, Laura Casani, Lina Badimon, Gemma Vilahur
BACKGROUND: Beneficial effects of high-density lipoproteins (HDL) seem altered in patients with symptomatic cardiovascular disease. We recently demonstrated in a swine model of ischemia-reperfusion (IR) that hypercholesterolemia abolishes HDL-related cardioprotection. OBJECTIVES: This study sought to investigate, using the same animal model, whether the reported impairment of HDL cardioprotective function was associated with alterations in HDL remodeling and functionality...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28647264/mgo-based-adsorbents-for-co2-adsorption-influence-of-structural-and-textural-properties-on-the-co2-adsorption-performance
#10
Gutiérrez-Bonilla Elvira, Granados-Correa Francisco, Sánchez-Mendieta Víctor, Morales-Luckie Raúl Alberto
A series of MgO-based adsorbents were prepared through solution-combustion synthesis and ball-milling process. The prepared MgO-based powders were characterized using X-ray diffraction, scanning electron microscopy, N2 physisorption measurements, and employed as potential adsorbents for CO2 adsorption. The influence of structural and textural properties of these adsorbents over the CO2 adsorption behaviour was also investigated. The results showed that MgO-based products prepared by solution-combustion and ball-milling processes, were highly porous, fluffy, nanocrystalline structures in nature, which are unique physico-chemical properties that significantly contribute to enhance their CO2 adsorption...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28607419/two-step-atp-driven-opening-of-cohesin-head
#11
Íñigo Marcos-Alcalde, Jesús I Mendieta-Moreno, Beatriz Puisac, María Concepción Gil-Rodríguez, María Hernández-Marcos, Diego Soler-Polo, Feliciano J Ramos, José Ortega, Juan Pié, Jesús Mendieta, Paulino Gómez-Puertas
The cohesin ring is a protein complex composed of four core subunits: Smc1A, Smc3, Rad21 and Stag1/2. It is involved in chromosome segregation, DNA repair, chromatin organization and transcription regulation. Opening of the ring occurs at the "head" structure, formed of the ATPase domains of Smc1A and Smc3 and Rad21. We investigate the mechanisms of the cohesin ring opening using techniques of free molecular dynamics (MD), steered MD and quantum mechanics/molecular mechanics MD (QM/MM MD). The study allows the thorough analysis of the opening events at the atomic scale: i) ATP hydrolysis at the Smc1A site, evaluating the role of the carboxy-terminal domain of Rad21 in the process; ii) the activation of the Smc3 site potentially mediated by the movement of specific amino acids; and iii) opening of the head domains after the two ATP hydrolysis events...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28576037/drug-release-profiles-of-modified-mcm-41-with-superparamagnetic-behavior-correlated-with-the-employed-synthesis-method
#12
Natalia I Cuello, Verónica R Elías, Silvia N Mendieta, Marcela Longhi, Mónica E Crivello, Marcos I Oliva, Griselda A Eimer
Mesoporous materials with superparamagnetic properties were successfully synthesized by two different methods: direct incorporation (DI) and wet impregnation (WI). The synthetized solids were evaluated as host of drugs for delivery systems and their physicochemical properties were characterized by XRD, ICP, N2 adsorption-desorption, spectroscopies of UV-Vis DR, FT-IR and their magnetic properties were measured. Indomethacin (IND) was incorporated into the materials and the kinetic of the release profiles was studied by applying the Pepas and Sahlin model...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28547780/advances-in-molecular-engineering-of-carbohydrate-binding-modules
#13
REVIEW
Silvia Armenta, Silvia Moreno-Mendieta, Zaira Sánchez-Cuapio, Sergio Sánchez, Romina Rodríguez-Sanoja
Carbohydrate-binding modules (CBMs) are non-catalytic domains that are generally appended to carbohydrate-active enzymes. CBMs have a broadly conserved structure that allows recognition of a notable variety of carbohydrates, in both their soluble and insoluble forms, as well as in their alpha and beta conformations and with different types of bonds or substitutions. This versatility suggests a high functional plasticity that is not yet clearly understood, in spite of the important number of studies relating protein structure and function...
September 2017: Proteins
https://www.readbyqxmd.com/read/28542310/geographic-distribution-of-angiostrongylus-cantonensis-in-wild-rats-rattus-rattus-and-terrestrial-snails-in-florida-usa
#14
Heather D Stockdale Walden, John D Slapcinsky, Shannon Roff, Jorge Mendieta Calle, Zakia Diaz Goodwin, Jere Stern, Rachel Corlett, Julia Conway, Antoinette McIntosh
The parasitic nematode Angiostrongylus cantonensis is a major cause of eosinophilic meningitis in humans, and has been documented in other incidental hosts such as birds, horses, dogs and non-human primates. It is endemic in Hawaii, and there have been sporadic reports in the southern continental United States. This parasite uses rats as definitive hosts and snails as intermediate hosts. In this study, we collected potential definitive and intermediate hosts throughout Florida to ascertain the geographic distribution in the state: Rats, environmental rat fecal samples, and snails were collected from 18 counties throughout the state...
2017: PloS One
https://www.readbyqxmd.com/read/28541715/biodegradation-and-kinetics-of-organic-compounds-and-heavy-metals-in-an-artificial-wetland-system-aws-by-using-water-hyacinths-as-a-biological-filter
#15
P F Rodríguez-Espinosa, J A Mendoza-Pérez, J Tabla-Hernandez, E Martínez-Tavera, M M Monroy-Mendieta
The objective of the present study was to investigate the ability of water hyacinth (Eichhornia crassipes) to absorb organic compounds (potassium hydrogen phthalate, sodium tartrate, malathion, 2,4-D and piroxicam). For the aforementioned purpose, an artificial wetland system (AWS) was constructed and filled with water hyacinth collected from Valsequillo Reservoir, Puebla, Mexico. Potassium hydrogen phthalate and sodium tartrate were measured in terms of Chemical Oxygen Demand (COD) and the Biological Oxygen Demand (BOD)...
May 25, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28507635/salivary-immunoglobulin-gene-expression-in-patients-with-caries
#16
Gema Regina Guadarrama Santín, Angel Visoso Salgado, Norma Margarita Montiel Bastida, Isaías de la Rosa Gómez, Jonnathan Guadalupe Santillán Benítez, Hugo Mendieta Zerón
BACKGROUND: Immunoglobulins mediate the host's humoral immune response are expressed in saliva. AIM: To quantify the FcαR, FcγRIIB, and FcαμR gene expression in the saliva of Mexican patients with caries in mixed and permanent dentition. SUBJECTS AND METHODS: This was a comparative cross-sectional study. mRNA was isolated from 200 μL of saliva following the RNA III Tissue Fresh-frozen protocol of the MagNA Pure LC Instrument 2.0 (Roche Diagnostics GmbH, Nederland BV) and the FcαR, FcαμR and FcγRIIB were quantified through TaqMan Assays...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28475152/prevalence-of-rotavirus-genogroup-a-and-norovirus-genogroup-ii-in-bassaseachic-falls-national-park-surface-waters-in-chihuahua-mexico
#17
Ma Carmen E Delgado-Gardea, Patricia Tamez-Guerra, Ricardo Gomez-Flores, Aurora Mendieta-Mendoza, Francisco Javier Zavala-Díaz de la Serna, Juan Francisco Contreras-Cordero, Gilberto Erosa-de la Vega, María Concepción Pérez-Recoder, Blanca Sánchez-Ramírez, Carmen González-Horta, Rocío Infante-Ramírez
In areas lacking potable water treatment, drinking contaminated water may represent a public health threat. In addition to enteropathogenic bacteria and parasites, fecal contamination in water environments is associated with the transmission of enteric viruses and other causal agents of infectious disease. Rotavirus and norovirus are the main enteric viral agents responsible for diarrheic outbreaks. The aim of the present study was to detect seasonal variation of rotavirus and norovirus in the surface water at Bassaseachic Falls National Park during 2013...
May 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28449403/effects-of-malnutrition-on-treatment-related-morbidity-and-survival-of-children-with-cancer-in-nicaragua
#18
Allison K Pribnow, Roberta Ortiz, Luis Fulgencio Báez, Luvy Mendieta, Sandra Luna-Fineman
BACKGROUND: Most children with cancer live in resource-limited countries where malnutrition is often prevalent. We identified the relationship between malnutrition and treatment-related morbidity (TRM), abandonment of therapy, and survival of children with cancer in Nicaragua to better inform targeted nutritional interventions. PROCEDURE: We conducted a retrospective review of patients aged 6 months to 18 years with newly diagnosed acute lymphoblastic leukemia, acute myeloid leukemia (AML), Wilms tumor, Hodgkin lymphoma, or Burkitt lymphoma (BL) who were treated between January 1, 2004, and December 31, 2007 at Children's Hospital Manuel de Jesus Rivera in Managua, Nicaragua...
November 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28373707/effect-of-water-dna-interactions-on-elastic-properties-of-dna-self-assembled-monolayers
#19
Carmen M Domínguez, Daniel Ramos, Jesús I Mendieta-Moreno, José L G Fierro, Jesús Mendieta, Javier Tamayo, Montserrat Calleja
DNA-water interactions have revealed as very important actor in DNA mechanics, from the molecular to the macroscopic scale. Given the particularly useful properties of DNA molecules to engineer novel materials through self-assembly and by bridging organic and inorganic materials, the interest in understanding DNA elasticity has crossed the boundaries of life science to reach also materials science and engineering. Here we show that thin films of DNA constructed through the self-assembly of sulfur tethered ssDNA strands demonstrate a Young's modulus tuning range of about 10 GPa by simply varying the environment relative humidity from 0% up to 70%...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28369293/report-on-mortality-from-gluteal-fat-grafting-recommendations-from-the-aserf-task-force
#20
M Mark Mofid, Steven Teitelbaum, Daniel Suissa, Arturo Ramirez-Montañana, Denis C Astarita, Constantino Mendieta, Robert Singer
Background: Gluteal fat grafting is among the fastest growing aesthetic procedures in the United States and around the world. Given numerous anecdotal and published reports of fatal and nonfatal pulmonary fat embolism resulting from this procedure, the Aesthetic Surgery Education and Research Foundation (ASERF) formed a Task Force to study this complication. Objectives: To determine the incidence of fatal and nonfatal pulmonary fat embolism associated with gluteal fat grafting and provide recommendations to decrease the risks of the procedure...
March 21, 2017: Aesthetic Surgery Journal
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