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https://www.readbyqxmd.com/read/29129405/neurogenesis-and-morphological-neural-alterations-closely-related-to-amyloid-%C3%AE-peptide-25-35-induced-memory-impairment-in-male-rats
#1
Eleazar Ramírez, Liliana Mendieta, Gonzalo Flores, I Daniel Limón
Memory impairment by the Amyloid-β 25-35 (Aβ25-35) peptide in animal models has provided an understanding of the causes behind the similar deterioration that occurs in Alzheimer's disease. However, it is uncertain if a decrease of dendritic spines and neurogenesis conduces to cognitive impairment by an impairment in the retrieval of stored memory. The aim of this study was to evaluate the consequences of impairment on spatial memory caused by the administration of the Aβ25-35 peptide in the hippocampus, which is associated whit morphological changes and neurogenesis in the dentate gyrus (DG)...
November 6, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29069487/nf-%C3%AE%C2%BAb1-ikk%C3%AE%C2%B5-gene-expression-and-clinical-activity-in-patients-with-rheumatoid-arthritis
#2
Fabiola Lilí Sarmiento Salinas, Jonnathan Guadalupe Santillán Benítez, María Dolores Hernández Navarro, Hugo Mendieta Zerón
Objective: Rheumatoid arthritis (RA) is a systemic and autoimmune disorder whose primary characteristic is the chronic inflammation of joints. The objective of this study was to evaluate whether there was an association between nuclear factor kappa beta1/IKK epsilon (NF-κB1/IKKε) gene expression and clinical activity in RA. Methods: Sixty patients with RA were included in the study: 30 with clinical activity and 30 with clinical remission. NF-κB1/IKKε gene expression was performed by real-time quantitative polymerase chain reaction through relative quantification with Taqman probes...
October 23, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/29063783/iron-therapy-substantially-restores-qeeg-maturational-lag-among-iron-deficient-anemic-infants
#3
Gloria A Otero, Thalía Fernández, F Bernardo Pliego-Rivero, Gustavo G Mendieta
OBJECTIVE: To use quantitative electroencephalography (qEEG) to assess the impact of iron-deficiency anemia on central nervous system maturation in the first year of life. METHOD: Twenty-five infants (3-12 months old) presenting ferropenic anemia (IDA) and 25 healthy controls (CTL1), matched by age/gender with the former, were studied in two stages. Electroencephalogram during spontaneous sleep was recorded from all participants; the fast Fourier transform was calculated to obtain absolute power (AP) and relative power (RP) qEEG measures...
October 24, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29050839/recommendations-by-the-spanish-society-of-rheumatology-on-the-use-of-biological-therapies-in-axial-spondyloarthritis
#4
Jordi Gratacós, Petra Díaz Del Campo Fontecha, Cristina Fernández-Carballido, Xavier Juanola Roura, Luis Francisco Linares Ferrando, Eugenio de Miguel Mendieta, Santiago Muñoz Fernández, Jose Luis Rosales-Alexander, Pedro Zarco Montejo, Mercedes Guerra Rodríguez, Victoria Navarro Compán
OBJECTIVE: Recent data published on biological therapy in axial spondyloarthritis (axSpA) since the last publication of the recommendations of the Spanish Society of Rheumatology (SER) has led to the generation of a review of these recommendations based on the best possible evidence. These recommendations should be a reference for rheumatologists and those involved in the treatment of patients with axSpA. METHODS: Recommendations were drawn up following a nominal group methodology and based on systematic reviews...
October 16, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29025216/assisted-salvage-of-ischemic-fasciocutaneous-flap-using-adipose-derived-mesenchymal-stem-cells-in-situ-revascularization
#5
Michael H Carstens, Mauricio Mendieta, Cecilia Pérez, Esperanza Villareal, Rodolfo Garcia
Adipose-derived mesenchymal stem cells (ASCs) have been shown to produce vascular endothelial growth factor (VEGF) and can increase perfusion in patients with critical limb ischemia. We will show that this concept can be applied to augment blood flow in zones of flap ischemia. We presented a case study of a 26-year-old man with a complex hand injury covered by a reverse radial perforator fasciocutaneous flap, which developed ischemic necrosis and was treated by debridement, transplantation of ASCs to enhance vascular support, and saline dressings...
July 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28928994/foxe1-mutation-screening-in-a-case-with-cleft-lip-hypothyroidism-and-thyroid-carcinoma-a-new-syndrome
#6
Hugo Mendieta-Zerón, Angélica Jiménez-Rosales, Carlos Jhovani Pérez-Amado, Silvia Jiménez-Morales
A 26-year-old woman is referred to the Internal Medicine consultation due to increases in laboratory studies associated with Papillary Thyroid Carcinoma (PTC) that was confirmed by histopathological studies. Her clinical history revealed that, at 3 months of age, she was successfully treated with surgery for cleft lip (CL) and at the age of 24 years was diagnosed with hypothyroidism. Single nucleotide polymorphisms (SNPs) in FOXE1 and its promoter regions have been associated with various etiologies related to the thyroid, including orofacial clefting, specially cleft palate (CP) and CL, hypothyroidism (HT), and thyroid cancer...
2017: Case Reports in Genetics
https://www.readbyqxmd.com/read/28901358/cadmium-1-4-cyclohexanedicarboxylato-coordination-polymers-bearing-different-di-alkyl-2-2-bipyridines-syntheses-crystal-structures-and-photoluminescence-studies
#7
Luis D Rosales-Vázquez, Víctor Sánchez-Mendieta, Alejandro Dorazco-González, Diego Martínez-Otero, Iván García-Orozco, Raúl A Morales-Luckie, Jonathan Jaramillo-Garcia, Antonio Téllez-López
Four coordination polymers have been synthesized using self-assembly solution reactions under ambient conditions, reacting Cd(ii) ions with 1,4-cyclohexanedicarboxylic acid in the presence of different 2,2'-bipyridine co-ligands: {[Cd(H2O)(e,a-cis-1,4-chdc)(2,2'-bpy)]·H2O}n (1); [Cd2(H2O)2(e,a-cis-1,4-chdc)2(4,4'-dmb)2]n (2); {[Cd(e,a-cis-1,4-chdc)(5,5'-dmb)]·H2O·CH3OH}n (3) and {[Cd(e,e-trans-1,4-chdc)(4,4'-dtbb)]·CH3OH}n (4), where 1,4-chdc = 1,4-cyclohexanedicarboxylato, 2,2'-bpy = 2,2'-bipyridine, 4,4'-dmb = 4,4'-dimethyl-2,2'-bipyridine, 5,5'-dmb = 5,5'-dimethyl-2,2'-bipyridine and 4,4'-dtbb = 4,4'-di-tert-butyl-2,2'-bipyridine...
September 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28879061/a-practical-guide-to-build-de-novo-assemblies-for-single-tissues-of-non-model-organisms-the-example-of-a-neotropical-frog
#8
Santiago Montero-Mendieta, Manfred Grabherr, Henrik Lantz, Ignacio De la Riva, Jennifer A Leonard, Matthew T Webster, Carles Vilà
Whole genome sequencing (WGS) is a very valuable resource to understand the evolutionary history of poorly known species. However, in organisms with large genomes, as most amphibians, WGS is still excessively challenging and transcriptome sequencing (RNA-seq) represents a cost-effective tool to explore genome-wide variability. Non-model organisms do not usually have a reference genome and the transcriptome must be assembled de-novo. We used RNA-seq to obtain the transcriptomic profile for Oreobates cruralis, a poorly known South American direct-developing frog...
2017: PeerJ
https://www.readbyqxmd.com/read/28818565/raw-starch-microparticles-have-immunostimulant-activity-in-mice-vaccinated-with-bcg-and-challenged-with-mycobacterium-tuberculosis
#9
Silvia Moreno-Mendieta, Jorge Barrios-Payán, Dulce Mata-Espinosa, Sergio Sánchez, Rogelio Hernández-Pando, Romina Rodríguez-Sanoja
The main challenge for vaccine development or improvement is the lack of safe adjuvants or immunostimulants that induce protective immune responses and can be used for mucosal immunization, which is a highly desirable strategy for vaccination against infectious diseases acquired by oral or intranasal routes. One promising alternative is the use of biodegradable and biocompatible polymeric microparticles. Recently, we developed an immobilization and delivery system with starch microparticles (SMPs) and a starch-binding domain (SBDtag) suitable for the mucosal administration of antigens and the induction of antigen-specific immune responses...
August 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28807651/recommendations-for-the-prescription-of-physical-exercise-for-patients-with-spondyloarthritis
#10
Mariano Tomás Flórez García, Loreto Carmona, Raquel Almodóvar, César Fernández de Las Peñas, Fernando García Pérez, M Ángeles Pérez Manzanero, José Manuel García García, Lidón Soriano Segarra, José Fernando Jiménez Díaz, Nuria Mendoza Laiz, Eugenio de Miguel Mendieta, Juan Carlos Torre Alonso, Luis Francisco Linares Ferrando, Eduardo Collantes Estévez, Jesús Sanz Sanz, Pedro Zarco Montejo
OBJECTIVE: To develop expert-based recommendations on physical activity and exercise for patients with spondyloarthritis (SpA). METHODS: Two discussion groups, one of physical therapists, rehabilitation physicians, and professionals of physical activity and sports, and another of rheumatologists interested in SpA, were held to discuss the results of a survey of rheumatologists on exercise and two focus groups with patients on barriers to exercise. Preliminary recommendations were drafted...
August 11, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28799821/a-review-of-palliative-and-hospice-care-in-the-context-of-islam-dying-with-faith-and-family
#11
Maximiliano Mendieta, Robert W Buckingham
BACKGROUND: By starting to understand Muslim culture, we can seek common ground with Islamic culture within the American experience and bridge opportunities for better palliative and hospice care here and in Middle Eastern countries. The United States, Canada, and Europe are education hubs for Middle Eastern students, creating an opportunity for the palliative and hospice care philosophy to gain access by proxy to populations of terminally ill patients who can benefit from end-of-life care...
November 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28783007/influence-of-the-chain-length-of-surfactant-in-the-modification-of-zeolites-and-clays-removal-of-atrazine-from-water-solutions
#12
Helen Paola Toledo-Jaldin, Alien Blanco-Flores, Víctor Sánchez-Mendieta, Osnieski Martín-Hernández
Removal potentials of a surfactant modified zeolite (SMZ) and clay (SMC) for atrazine adsorption were evaluated. Materials were modified with hexadecyl trimethyl ammonium bromide (HDTMA) and benzyl octadecyl dimethyl ammonium chloride (BODA) considering the critical miscelar concentration (CMC) of each one (0.94 and 0.041 meq/L, respectively). The influence of the surfactant was analyzed in detail, particularly the formation of surfactant layers (complete or partial) connected with the length of the surfactant tail (16 and 18 methyl groups or number of carbons in the chain)...
August 7, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28716729/study-of-new-interactions-of-glitazone-s-stereoisomers-and-the-endogenous-ligand-15d-pgj2-on-six-different-ppar-gamma-proteins
#13
Samuel Álvarez-Almazán, Martiniano Bello, Feliciano Tamay-Cach, Marlet Martínez-Archundia, Diana Alemán-González-Duhart, José Correa-Basurto, Jessica Elena Mendieta-Wejebe
Diabetes mellitus is a chronic disease characterized by hyperglycemia, insulin resistance and hyperlipidemia. Glitazones or thiazolidinediones (TZD) are drugs that act as insulin-sensitizing agents whose molecular target is the peroxisome proliferator-activated receptor gamma (PPARγ). The euglycemic action of TZD has been linked with the induction of type 4 glucose transporter. However, it has been shown that the effect of TZD depends on the specific stereoisomer that interacts with PPARγ. Therefore, this work is focused on exploring the interactions and geometry adopted by glitazone's stereoisomers and one endogenous ligand on different conformations of the six crystals of the PPARγ protein using molecular docking and molecular dynamics (MD) simulations accompanied by the MMGBSA approach...
October 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28683964/detrimental-effect-of-hypercholesterolemia-on-high-density-lipoprotein-particle-remodeling%C3%A2-in%C3%A2-pigs
#14
Teresa Padró, Judit Cubedo, Sandra Camino, Maria Teresa Béjar, Soumaya Ben-Aicha, Guiomar Mendieta, Joan Carles Escolà-Gil, Rafael Escate, Manuel Gutiérrez, Laura Casani, Lina Badimon, Gemma Vilahur
BACKGROUND: Beneficial effects of high-density lipoproteins (HDL) seem altered in patients with symptomatic cardiovascular disease. We recently demonstrated in a swine model of ischemia-reperfusion (IR) that hypercholesterolemia abolishes HDL-related cardioprotection. OBJECTIVES: This study sought to investigate, using the same animal model, whether the reported impairment of HDL cardioprotective function was associated with alterations in HDL remodeling and functionality...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28647264/mgo-based-adsorbents-for-co2-adsorption-influence-of-structural-and-textural-properties-on-the-co2-adsorption-performance
#15
Gutiérrez-Bonilla Elvira, Granados-Correa Francisco, Sánchez-Mendieta Víctor, Morales-Luckie Raúl Alberto
A series of MgO-based adsorbents were prepared through solution-combustion synthesis and ball-milling process. The prepared MgO-based powders were characterized using X-ray diffraction, scanning electron microscopy, N2 physisorption measurements, and employed as potential adsorbents for CO2 adsorption. The influence of structural and textural properties of these adsorbents over the CO2 adsorption behaviour was also investigated. The results showed that MgO-based products prepared by solution-combustion and ball-milling processes, were highly porous, fluffy, nanocrystalline structures in nature, which are unique physico-chemical properties that significantly contribute to enhance their CO2 adsorption...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28607419/two-step-atp-driven-opening-of-cohesin-head
#16
Íñigo Marcos-Alcalde, Jesús I Mendieta-Moreno, Beatriz Puisac, María Concepción Gil-Rodríguez, María Hernández-Marcos, Diego Soler-Polo, Feliciano J Ramos, José Ortega, Juan Pié, Jesús Mendieta, Paulino Gómez-Puertas
The cohesin ring is a protein complex composed of four core subunits: Smc1A, Smc3, Rad21 and Stag1/2. It is involved in chromosome segregation, DNA repair, chromatin organization and transcription regulation. Opening of the ring occurs at the "head" structure, formed of the ATPase domains of Smc1A and Smc3 and Rad21. We investigate the mechanisms of the cohesin ring opening using techniques of free molecular dynamics (MD), steered MD and quantum mechanics/molecular mechanics MD (QM/MM MD). The study allows the thorough analysis of the opening events at the atomic scale: i) ATP hydrolysis at the Smc1A site, evaluating the role of the carboxy-terminal domain of Rad21 in the process; ii) the activation of the Smc3 site potentially mediated by the movement of specific amino acids; and iii) opening of the head domains after the two ATP hydrolysis events...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28576037/drug-release-profiles-of-modified-mcm-41-with-superparamagnetic-behavior-correlated-with-the-employed-synthesis-method
#17
Natalia I Cuello, Verónica R Elías, Silvia N Mendieta, Marcela Longhi, Mónica E Crivello, Marcos I Oliva, Griselda A Eimer
Mesoporous materials with superparamagnetic properties were successfully synthesized by two different methods: direct incorporation (DI) and wet impregnation (WI). The synthetized solids were evaluated as host of drugs for delivery systems and their physicochemical properties were characterized by XRD, ICP, N2 adsorption-desorption, spectroscopies of UV-Vis DR, FT-IR and their magnetic properties were measured. Indomethacin (IND) was incorporated into the materials and the kinetic of the release profiles was studied by applying the Pepas and Sahlin model...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28547780/advances-in-molecular-engineering-of-carbohydrate-binding-modules
#18
REVIEW
Silvia Armenta, Silvia Moreno-Mendieta, Zaira Sánchez-Cuapio, Sergio Sánchez, Romina Rodríguez-Sanoja
Carbohydrate-binding modules (CBMs) are non-catalytic domains that are generally appended to carbohydrate-active enzymes. CBMs have a broadly conserved structure that allows recognition of a notable variety of carbohydrates, in both their soluble and insoluble forms, as well as in their alpha and beta conformations and with different types of bonds or substitutions. This versatility suggests a high functional plasticity that is not yet clearly understood, in spite of the important number of studies relating protein structure and function...
September 2017: Proteins
https://www.readbyqxmd.com/read/28542310/geographic-distribution-of-angiostrongylus-cantonensis-in-wild-rats-rattus-rattus-and-terrestrial-snails-in-florida-usa
#19
Heather D Stockdale Walden, John D Slapcinsky, Shannon Roff, Jorge Mendieta Calle, Zakia Diaz Goodwin, Jere Stern, Rachel Corlett, Julia Conway, Antoinette McIntosh
The parasitic nematode Angiostrongylus cantonensis is a major cause of eosinophilic meningitis in humans, and has been documented in other incidental hosts such as birds, horses, dogs and non-human primates. It is endemic in Hawaii, and there have been sporadic reports in the southern continental United States. This parasite uses rats as definitive hosts and snails as intermediate hosts. In this study, we collected potential definitive and intermediate hosts throughout Florida to ascertain the geographic distribution in the state: Rats, environmental rat fecal samples, and snails were collected from 18 counties throughout the state...
2017: PloS One
https://www.readbyqxmd.com/read/28541715/biodegradation-and-kinetics-of-organic-compounds-and-heavy-metals-in-an-artificial-wetland-system-aws-by-using-water-hyacinths-as-a-biological-filter
#20
P F Rodríguez-Espinosa, J A Mendoza-Pérez, J Tabla-Hernandez, E Martínez-Tavera, M M Monroy-Mendieta
The objective of the present study was to investigate the ability of water hyacinth (Eichhornia crassipes) to absorb organic compounds (potassium hydrogen phthalate, sodium tartrate, malathion, 2,4-D and piroxicam). For the aforementioned purpose, an artificial wetland system (AWS) was constructed and filled with water hyacinth collected from Valsequillo Reservoir, Puebla, Mexico. Potassium hydrogen phthalate and sodium tartrate were measured in terms of Chemical Oxygen Demand (COD) and the Biological Oxygen Demand (BOD)...
May 25, 2017: International Journal of Phytoremediation
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