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https://www.readbyqxmd.com/read/29779956/targeted-covalent-inhibition-of-prolyl-oligopeptidase-pop-discovery-of-sulfonylfluoride-peptidomimetics
#1
Salvador Guardiola, Roger Prades, Laura Mendieta, Arwin J Brouwer, Jelle Streefkerk, Laura Nevola, Teresa Tarragó, Rob M J Liskamp, Ernest Giralt
Prolyl oligopeptidase (POP), a serine protease highly expressed in the brain, has recently emerged as an enticing therapeutic target for the treatment of cognitive and neurodegenerative disorders. However, most reported inhibitors suffer from short duration of action, poor protease selectivity, and low blood-brain barrier (BBB) permeability, which altogether limit their potential as drugs. Here, we describe the structure-based design of the first irreversible, selective, and brain-permeable POP inhibitors. At low-nanomolar concentrations, these covalent peptidomimetics produce a fast, specific, and sustained inactivation of POP, both in vitro and in human cells...
May 7, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29768608/perception-of-body-and-corporeality-in-men-practicing-male-prostitution-in-guadalajara-mexico
#2
Giovane Mendieta-Izquierdo
OBJECTIVE: To interpret the perception of the body and corporeality in a group of men practicing male prostitution in the center of Guadalajara, Jalisco, Mexico. METHOD: An interpretive phenomenological study from the perspective of Heidegger; the perception of the body is taken as a category of analysis based on 20 in-depth interviews with 13 males practicing prostitution. RESULTS: The interpretation of the body and corporeality in men who practice male prostitution centers on the following categories: a) the dirty body, stigma, b) body-seeking opportunities, c) the body and corporeality, appealing to customers, d) the initial contact and body language, and e) the value assigned to the body, the rate...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29748674/laser-induced-formation-of-bismuth-nanoparticles
#3
Marcelo Assis, Eloísa Cordoncillo, Rafael Torres-Mendieta, Héctor Beltrán-Mir, Gladys Mínguez-Vega, Amanda Fernandes Gouveia, Edson Leite, Juan Andrés, Elson Longo
In the current communication, the synthesis of metallic Bi nanoparticles with coexisting crystallographic structures (rhombohedral, monoclinic, and cubic) obtained via direct femtosecond laser irradiation of NaBiO3 is demonstrated for the first time. By exploring the use of high laser power values, it is revealed that the promoted laser-mediated reactions lead to the synthesis of coexisting phases in metal nanoparticles, which may be a widely occurring phenomenon in other materials under femtosecond laser irradiation, and a fundamental concern for laser-based nanofabrication...
May 11, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29700099/effect-of-a549-neuroendocrine-differentiation-on-cytotoxic-immune-response
#4
Irasema Mendieta, Rosa-Elvira Nunez-Anita, Gilberto Pérez-Sánchez, Lenin Pavon, Alfredo Rodríguez-Cruz, Guadalupe Garcia-Alcocer, Laura Cristina Berumen
The present study was designed to determine the effects of factors secreted by the lung adenocarcinoma cell line with the neuroendocrine phenotype, A549NED, on cytotoxic T lymphocytes (CTL) activity in vitro. A perspective that integrates the nervous, endocrine and immune system in cancer research is essential to understand the complexity of dynamic interactions in tumours. Extensive clinical research suggests that neuroendocrine differentiation (NED) is correlated with worse patient outcomes; however, little is known regarding the effects of neuroendocrine factors on the communication between the immune system and neoplastic cells...
April 26, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29682816/subtropical-goats-ovulate-in-response-to-the-male-effect-after-a-prolonged-treatment-of-artificial-long-days-to-stimulate-their-milk-yield
#5
E S Mendieta, J A Delgadillo, J A Flores, M J Flores, E Nandayapa, L I Vélez, L A Zarazaga, M Bedos, A Terrazas, H Hernández
The objectives of this study were to determine (i) if in subtropical goats that gave birth during mid-December, the exposition to an artificial long-day photoperiod consisting in only 14 hr of light per day can increase the milk yield and (ii) to test whether these females can respond to the male effect at the end of the prolonged photoperiodic treatment. In experiment 1, 17 lactating goats were maintained under natural short days (control group), while another 22 goats were maintained under artificial long days (treated group) consisting in 14 hr light and 10 hr darkness starting at day 10 of lactation...
April 22, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29652870/surveillance-for-the-identification-of-cases-of-acute-respiratory-infection-by-enterovirus-d68-in-children-in-a-tertiary-level-care-hospital-during-2014-2016
#6
Ana Estela Gamiño-Arroyo, José Luis Sánchez-Huerta, Alicia Elhaín de la Garza-López, Israel Parra-Ortega, Noé Escobar-Escamilla, Edgar Mendieta-Condado, Fabiola Garcés-Ayala, Gisela Barrera-Badillo, José Ernesto Ramírez-González, José Alberto Díaz-Quiñonez, Daniela de la Rosa-Zamboni
Background: The reemergence of enterovirus D68 (EV-D68) infections in the United States was reported from August-October 2014 (691 cases). In Mexico, an outbreak at the National Institute of Respiratory Diseases was reported (24 cases). The results of epidemiological surveillance of Enterovirus sp. (EV) and other respiratory viruses in a national pediatric tertiary care level hospital are presented. Methods: Following the alert issued by the reemergence of EV-D68 in 2014, epidemiological surveillance -which only detected respiratory viruses by PCR in patients with influenza-like illness using nasopharyngeal swabs- expanded to include children with asthma exacerbation or acute respiratory distress...
2018: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29625703/treatment-of-a-refractory-venous-ulcer-with-terminal-interruption-of-the-reflux-source
#7
M Mendieta-Eckert, J L Azpiazu-Macho, N Landa-Gundin
No abstract text is available yet for this article.
April 3, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29593828/electrocardiogram-delineation-in-a-wistar-rat-experimental-model
#8
Pedro David Arini, Sergio Liberczuk, Javier Gustavo Mendieta, Martín Santa María, Guillermo Claudio Bertrán
Background and Objectives: The extensive use of electrocardiogram (ECG) recordings during experimental protocols using small rodents requires an automatic delineation technique in the ECG with high performance. It has been shown that the wavelet transform (WT) based ECG delineator is a suitable tool to delineate electrocardiographic waveforms. The aim of this work is to implement and evaluate the ECG waves delineation in Wistar rats applying WT. We also describe the ECG signal of the Wistar rats giving the characteristics of its spectrum among other useful information...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29575077/interferon-alpha-induced-psoriasis-in-a-teenager
#9
Karen L Mendieta, Mahwish Irfan, Esteban Fernandez Faith
Exacerbation of preexisting and development of new-onset psoriasis have been reported secondary to interferon treatment and, more recently, with newer biologic agents. We report a case of interferon-induced psoriasis in an adolescent with hepatitis C, a rarely reported medication reaction in children. This case highlights the importance of reviewing a patient's medication list when evaluating cutaneous disorders.
March 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29519497/preface
#10
EDITORIAL
Robert F Centeno, Constantino G Mendieta
No abstract text is available yet for this article.
April 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29519485/classification-system-for-gluteal-evaluation-revisited
#11
REVIEW
Constantino G Mendieta, Aditya Sood
The buttock area has received much media attention in recent years, which has produced increased patient demand for buttock reshaping or contouring and augmentation. Increasing patient demand has necessitated a more structured approach to evaluation of gluteal anatomy and the development of surgical procedures to enhance its beauty.
April 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29460114/peripheral-administration-of-tetanus-toxin-hc-fragment-prevents-mpp-toxicity-in-vivo
#12
Natalia Moreno-Galarza, Liliana Mendieta, Victoria Palafox-Sánchez, Mireia Herrando-Grabulosa, Carles Gil, Daniel I Limón, José Aguilera
Several studies have shown that intrastriatal application of 1-methyl-4-phenylpyridinium (MPP+ ) produces similar biochemical changes in rat to those seen in Parkinson's disease (PD), such as dopaminergic terminal degeneration and consequent appearance of motor deficits, making the MPP+ lesion a widely used model of parkinsonism in rodents. Previous results from our group have shown a neuroprotective effect of the carboxyl-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) under different types of stress...
February 19, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29382839/towards-the-scale-up-of-the-formation-of-nanoparticles-on-%C3%AE-ag-2-wo-4-with-bactericidal-properties-by-femtosecond-laser-irradiation
#13
Marcelo Assis, Eloisa Cordoncillo, Rafael Torres-Mendieta, Héctor Beltrán-Mir, Gladys Mínguez-Vega, Regiane Oliveira, Edson R Leite, Camila C Foggi, Carlos E Vergani, Elson Longo, Juan Andrés
In recent years, complex nanocomposites formed by Ag nanoparticles coupled to an α-Ag2 WO4 semiconductor network have emerged as promising bactericides, where the semiconductor attracts bacterial agents and Ag nanoparticles neutralize them. However, the production rate of such materials has been limited to transmission electron microscope processing, making it difficult to cross the barrier from basic research to real applications. The interaction between pulsed laser radiation and α-Ag2 WO4 has revealed a new processing alternative to scale up the production of the nanocomposite resulting in a 32-fold improvement of bactericidal performance, and at the same time obtaining a new class of spherical Agx Wy Oz nanoparticles...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29382477/-tolerance-safety-and-efficacy-of-the-one-day-preparation-of-peg3350-bisacodyl-compared-to-2-days-of-peg3350-bisacodyl-in-pediatric-patients
#14
Ligia Marcela Portillo Canizalez, Gerardo Blanco Rodriguez, Gustavo Teyssier Morales, Jaime Penchyna Grub, Sean Trauernicht Mendieta, Jessie Nallely Zurita-Cruz
BACKGROUND: Multiple intestinal preparations have been used in children undergoing colonoscopy, with variable limitation due to acceptance, tolerance, and proper cleaning. The objective of this study was to compare the tolerability, safety and efficacy of the colonoscopy preparation with 1 day with PEG 3350 (poliethylenglycol) (4g/kg/day) + bisacodyl compared to 2 days of preparation with PEG 3350 (2g/kg/day) + bisacodyl in pediatric patients. METHODS: A clinical, randomized, and blind trial was performed...
September 2017: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29373727/determinants-of-reduced-genetic-capacity-for-butyrate-synthesis-by-the-gut-microbiome-in-crohn-s-disease-and-ulcerative-colitis
#15
Emilio J Laserna-Mendieta, Adam G Clooney, Julián F Carretero-Gomez, Carthage Moran, Donal Sheehan, James A Nolan, Colin Hill, Cormac G M Gahan, Susan A Joyce, Fergus Shanahan, Marcus J Claesson
Background and Aims: Alterations in short chain fatty acid metabolism, particularly butyrate, have been reported in inflammatory bowel disease, but results have been conflicting because of small study numbers and failure to distinguish disease type, activity or other variables such as diet. We performed a comparative assessment of the capacity of the microbiota for butyrate synthesis, by quantifying butyryl-CoA:acetate CoA-transferase [BCoAT] gene content in stool from patients with Crohn's disease [CD; n = 71], ulcerative colitis [UC; n = 58] and controls [n = 75], and determined whether it was related to active vs inactive inflammation, microbial diversity, and composition and/or dietary habits...
January 24, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29371371/genome-sequence-of-a-rabies-virus-isolated-from-a-dog-in-chiapas-mexico-2013
#16
Sandra Pérez-Agüeros, Joanna María Ortiz-Alcántara, Fabiola Garcés-Ayala, Edgar Mendieta-Condado, Elizabeth González-Durán, Nidia Aréchiga-Ceballos, Martin Melo-Munguía, Susana Chávez-López, Albert Sandoval-Borja, Mauricio Gómez-Sierra, Rita Terán-Toledo, David Martínez-Solís, Israel Animas-Vargas, Beatriz Escamilla-Ríos, Belem Torres-Longoria, Irma López-Martínez, Lucía Hernández-Rivas, José Alberto Díaz-Quiñonez, José Ernesto Ramírez-González
Rabies virus (RABV), a member of the genus Lyssavirus , causes encephalitis that is almost always fatal following the onset of clinical signs. Here, we report the complete codifying sequence of an RABV isolated from a dog in Mexico. Molecular data showed that this strain belongs to the Chiapas lineage.
January 25, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29369983/gluteal-augmentation-and-enhancement-of-the-female-silhouette-analysis-and-technique
#17
Constantino Mendieta, James M Stuzin
Dr. Constantino Mendieta demonstrates and details his personal technique for gluteal augmentation. The video demonstration is divided into three parts: Part I, Aesthetic Analysis and Preoperative Marking; Part II, Creating the Female Silhouette with Circumferential Lipoplasty; and Part III, Autogenous Gluteal Augmentation. Artistic concepts for gluteal augmentation and contouring the female silhouette and technical considerations for patient safety are emphasized. This Master Series Video article is the first in a planned series of video vignettes...
February 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29289789/zoledronic-acid-increases-the-prevalence-of-medication-related-osteonecrosis-of-the-jaw-in-a-dose-dependent-manner-in-rice-rats-oryzomys-palustris-with-localized-periodontitis
#18
J G Messer, J L Mendieta Calle, J M Jiron, E J Castillo, C Van Poznak, N Bhattacharyya, D B Kimmel, J I Aguirre
OBJECTIVE: Investigate role of dose/duration of zoledronic acid (ZOL), a powerful anti-resorptive (pAR), on prevalence of medication-related osteonecrosis of the jaw (MRONJ) in rice rats (Oryzomys palustris), a species with natural susceptibility to food impaction-induced localized periodontitis (FILP). We hypothesize that ZOL induces MRONJ lesions in rice rats with FILP, and that the prevalence of MRONJ rises with increasing dose and duration of ZOL treatment. METHODS: We performed a toxicology experiment with clinically-relevant doses of ZOL in female rats (N=230) fed standard (STD) rodent chow...
March 2018: Bone
https://www.readbyqxmd.com/read/29275329/amino-acid-residues-in-hiv-2-reverse-transcriptase-that-restrict-the-development-of-nucleoside-analogue-resistance-through-the-excision-pathway
#19
Mar Álvarez, María Nevot, Jesús Mendieta, Miguel A Martínez, Luis Menéndez-Arias
Nucleoside reverse transcriptase (RT) inhibitors (NRTIs) are the backbone of current antiretroviral treatments. However, the emergence of viral resistance against NRTIs is a major threat to their therapeutic effectiveness. In HIV-1, NRTI resistance-associated mutations either reduce RT-mediated incorporation of NRTI triphosphates (discrimination mechanism) or confer an ATP-mediated nucleotide excision activity that removes the inhibitor from the 3' terminus of DNA primers, enabling further primer elongation (excision mechanism)...
February 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29220818/reuse-of-sustainable-materials-for-xylenol-orange-dye-and-copper-ii-ion-ammoniacal-removal
#20
M I Garrudo-Guirado, A Blanco-Flores, H P Toledo-Jaldin, V Sánchez-Mendieta, A R Vilchis-Néstor
Water pollution caused by heavy metals and organic compounds is an environmental problem with negative impact, making the restoration of water quality a priority. In this paper, the adsorption of xylenol orange dye (XO) on vitreous tuff mineral (VT) was studied. It was established that the adsorption capacity of VT was 45.17 mg/g. The removal was carried out by interactions between active sites on the surface of the material and the functional groups of the dye. The solid waste obtained from this process (VTXO) was reused as adsorbent material for Cu removal in the form of the complex Cu-NH3 because this process was done in an ammoniacal medium...
January 15, 2018: Journal of Environmental Management
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