Alexandre Pichard, Sara Marcatili, Jihad Karam, Julie Constanzo, Riad Ladjohounlou, Alan Courteau, Marta Jarlier, Nathalie Bonnefoy, Sebastian Patzke, Vilde Stenberg, Peter Coopman, Guillaume Cartron, Isabelle Navarro-Teulon, Ada Repetto-Llamazares, Helen Heyerdahl, Jostein Dahle, Manuel Bardiès, Jean-Pierre Pouget
Some patients with B-cell non-Hodkin lymphoma Lymphoma (NHL) become refractory to rituximab (anti-CD20 antibody) therapy associated with chemotherapy. Here, the effect of the anti-CD37 antibody-radionuclide conjugate lutetium-177 (177 Lu)-lilotomab (Betalutin® ) was investigated in preclinical models of NHL. In SCID mice bearing DOHH2 (transformed follicular lymphoma, FL) cell xenografts, 177 Lu-lilotomab significantly delayed tumor growth, even at low activity (100 MBq/kg). In athymic mice bearing OCI-Ly8 (diffuse large B-cell lymphoma, DLBCL) or Ramos (Burkitt's lymphoma) cell xenografts, 177 Lu-lilotomab activity had to be increased to 500 MBq/kg to show a significant tumor growth delay...
May 2020: Leukemia