András Maifeld, Johannes Wild, Tine V Karlsen, Natalia Rakova, Elisa Wistorf, Peter Linz, Rebecca Jung, Anna Birukov, Vladimir-Andrey Gimenez-Rivera, Nicola Wilck, Theda Bartolomaeus, Ralf Dechend, Markus Kleinewietfeld, Sofia K Forslund, Andreas Krause, Georgios Kokolakis, Sandra Philipp, Björn E Clausen, Anna Brand, Ari Waisman, Florian C Kurschus, Joanna Wegner, Michael Schultheis, Friedrich C Luft, Michael Boschmann, Marcus Kelm, Helge Wiig, Titus Kuehne, Dominik N Müller, Susanne Karbach, Lajos Markó
Sodium can accumulate in the skin at concentrations exceeding serum levels. A high sodium environment can lead to pathogenic T helper 17 cell expansion. Psoriasis is a chronic inflammatory skin disease in which IL-17‒producing T helper 17 cells play a crucial role. In an observational study, we measured skin sodium content in patients with psoriasis and in age-matched healthy controls by Sodium-23 magnetic resonance imaging. Patients with PASI > 5 showed significantly higher sodium and water content in the skin but not in other tissues than those with lower PASI or healthy controls...
January 2022: Journal of Investigative Dermatology