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https://www.readbyqxmd.com/read/27539685/phosphate-or-citrate-buffered-tirofiban-versus-unfractionated-heparin-and-its-impact-on-thrombocytopenia-and-clinical%C3%A2-outcomes-in-patients-with-acute%C3%A2-coronary-syndrome-a-post-hoc-analysis-from-the-prism-trial
#1
Marianna Adamo, Sara Ariotti, Francesco Costa, Salvatore Curello, Aris Moschovitis, Ton de Vries, Harvey D White, Stephan Windecker, Marco Valgimigli
OBJECTIVES: The aim of this study was to investigate whether the 2 tirofiban formulations tested in the early and late phases of the PRISM (Platelet Receptor Inhibitor in Ischemic Syndrome Management) trial might differ with respect to risk for thrombocytopenia and clinical outcomes compared with unfractionated heparin (UFH). BACKGROUND: Citrate-buffered tirofiban is currently marketed as brand-name drug. However, tirofiban has recently been promoted in some countries as a generic drug with different formulations, such as phosphate-buffered product...
August 22, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27379755/organic-gunshot-residues-observations-about-sampling-and-transfer-mechanisms
#2
Anne-Laure Gassner, Cristina Ribeiro, Joanna Kobylinska, Arie Zeichner, Céline Weyermann
This work aimed at studying the sampling, storage, transfer and persistence of organic gunshot residue (OGSR), mainly stabilizers, using liquid chromatography hyphenated to mass spectrometry. Collection using swabs and stubs was compared through sequential sampling in terms of amount of residues left on the hand of a shooter. While stubs collected nearly all residues, swabs left about 50% of the residues on the hands. Moreover, the study of storage conditions after sampling showed that stubs were more stable than swabs and could be held at room temperature without significant compound loss up to 2weeks...
September 2016: Forensic Science International
https://www.readbyqxmd.com/read/27069082/patient-reported-outcomes-labeling-for-products-approved-by-the-office-of-hematology-and-oncology-products-of-the-us-food-and-drug-administration-2010-2014
#3
Ari Gnanasakthy, Carla DeMuro, Marci Clark, Emily Haydysch, Esprit Ma, Vijayveer Bonthapally
PURPOSE: To review the use of patient-reported outcome (PRO) data in medical product labeling granted by the US Food and Drug Administration (FDA) for new molecular entities and biologic license applications by the FDA Office of Hematology and Oncology Products (OHOP) between January 2010 and December 2014, to elucidate challenges faced by OHOP for approving PRO labeling, and to understand challenges faced by drug manufacturers to include PRO end points in oncology clinical trials. METHODS: FDA Drug Approval Reports by Month were reviewed to obtain the number of new molecular entities and biologic license applications approved from 2010 to 2014...
June 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26292225/validation-of-cut-points-for-evaluating-the-intensity-of-physical-activity-with-accelerometry-based-mean-amplitude-deviation-mad
#4
Henri Vähä-Ypyä, Tommi Vasankari, Pauliina Husu, Ari Mänttäri, Timo Vuorimaa, Jaana Suni, Harri Sievänen
PURPOSE: Our recent study of three accelerometer brands in various ambulatory activities showed that the mean amplitude deviation (MAD) of the resultant acceleration signal performed best in separating different intensity levels and provided excellent agreement between the three devices. The objective of this study was to derive a regression model that estimates oxygen consumption (VO2) from MAD values and validate the MAD-based cut-points for light, moderate and vigorous locomotion against VO2 within a wide range of speeds...
2015: PloS One
https://www.readbyqxmd.com/read/26281087/-the-role-of-simulation-in-surgical-training-a-new-era
#5
Guy Rofe, Arie Lissak, Orly Brandes-Klein, Eran Segev, Moran Paz, Yael Hod, Menashe Barzilai, Ron Auslender, Chen Shapira, Yuval Kaufman
Surgical training, which was traditionally based on the apprentice model, is undergoing a fundamental change since the introduction of virtual reality simulators into the training program of surgical residents. With the introduction of these simulators we can expect to see an improvement in the surgical abilities of new surgeons and a decrease in costs--as seen in the aviation world. Virtual reality simulators include a visual and tactile interface which is meant to train young surgeons in full procedure before the actual surgery...
June 2015: Harefuah
https://www.readbyqxmd.com/read/24713563/shear-bond-resistance-and-enamel-surface-comparison-after-the-bonding-and-debonding-of-ceramic-and-metallic-brackets
#6
COMPARATIVE STUDY
José Maurício da Rocha, Marco Abdo Gravina, Marcio José da Silva Campos, Cátia Cardoso Abdo Quintão, Carlos Nelson Elias, Robert Willer Farinazzo Vitral
OBJECTIVE: To evaluate, in vitro, the shear bond strength presented by three brands of polycrystalline ceramic brackets and one brand of metallic bracket; verify the adhesive remnant index (ARI) after the tests, and analyze, through scanning electron microscopy (SEM) the enamel surface topography after debonding, detecting the release of mineral particles. METHODS: Sixty bovine lower incisors were used. Three ceramic brackets (Allure®, InVu®, and Clarity®) and one metallic bracket (Geneus®) were bonded with Transbond XT®...
January 2014: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/23923661/-professor-arie-brand-vision-and-development-interview-by-andries-van-foreest-and-ko-minderhoud
#7
Arie Brand
No abstract text is available yet for this article.
July 1, 2013: Tijdschrift Voor Diergeneeskunde
https://www.readbyqxmd.com/read/23683771/miglustat-therapy-in-type-1-gaucher-disease-clinical-and-safety-outcomes-in-a-multicenter-retrospective-cohort-study
#8
David J Kuter, Atul Mehta, Carla E M Hollak, Pilar Giraldo, Derralynn Hughes, Nadia Belmatoug, Monika Brand, Audrey Muller, Berthold Schaaf, Ruben Giorgino, Ari Zimran
We evaluated clinical and safety outcomes in adult patients with type 1 Gaucher disease receiving miglustat in clinical practice settings. An observational, retrospective cohort study was conducted in centers across the EU and the USA. Medical chart data were collected from consecutive patients between the 20th November 2002 and 31st December 2008. A total of 115 patients were included; 34 (30%) were enzyme replacement therapy-naïve ('naïve') and 81 (70%) were enzyme pretreated ('pretreated'). Median (range) miglustat exposures in these groups were 15...
August 2013: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/23537954/the-cabg-syntax-score-an-angiographic-tool-to-grade-the-complexity-of-coronary-disease-following-coronary-artery-bypass-graft-surgery-from-the-syntax-left-main-angiographic-syntax-le-mans-substudy
#9
RANDOMIZED CONTROLLED TRIAL
Vasim Farooq, Chrysafios Girasis, Michael Magro, Yoshinobu Onuma, Marie Angèle Morel, Jung Ho Heo, Hector Garcia-Garcia, Arie Pieter Kappetein, Marcel van den Brand, David R Holmes, Michael Mack, Ted Feldman, Antonio Colombo, Elisabeth Ståhle, Stefan James, Didier Carrié, Gerard Fournial, Gerrit-Anne van Es, Keith D Dawkins, Friedrich W Mohr, Marie-Claude Morice, Patrick W Serruys
AIMS: The SYNTAX Score (SXscore) has established itself as an important prognostic tool in patients undergoing percutaneous coronary intervention (PCI). A limitation of the SXscore is the inability to differentiate outcomes in patients who have undergone prior coronary artery bypass graft (CABG) surgery. The CABG SXscore was devised to address this limitation. METHODS AND RESULTS: In the SYNTAX-LE MANS substudy 115 patients with unprotected left main coronary artery disease (isolated or associated with one, two or three-vessel disease) treated with CABG were prospectively assigned to undergo a 15-month coronary angiogram...
March 2013: EuroIntervention
https://www.readbyqxmd.com/read/22917604/the-cabg-syntax-score-an-angiographic-tool-to-grade-the-complexity-of-coronary-disease-following-coronary-artery-bypass-graft-surgery-from-the-syntax-left-main-angiographic-syntax-le-mans-substudy
#10
Vasim Farooq, Chrysafios Girasis, Michael Magro, Yoshinobu Onuma, Marie Angèle Morel, Jung Ho Heo, Hector Garcia-Garcia, Arie Pieter Kappetein, Marcel van den Brand, David R Holmes, Michael Mack, Ted Feldman, Antonio Colombo, Elisabeth Ståhle, Stefan James, Didier Carrié, Gerard Fournial, Gerrit Anne van Es, Keith D Dawkins, Friedrich W Mohr, Marie-Claude Morice, Patrick W Serruys
Aims: The SYNTAX Score (SXscore) has established itself as an important prognostic tool in patients undergoing percutaneous coronary intervention (PCI). A limitation of the SXscore is the inability to differentiate outcomes in patients who have undergone prior coronary artery bypass graft (CABG) surgery. The CABG SXscore was devised to address this limitation. Methods and results: In the SYNTAX-LE MANS substudy 115 patients with unprotected left main coronary artery disease (isolated or associated with one, two or three-vessel disease) treated with CABG were prospectively assigned to undergo a 15-month coronary angiogram...
August 25, 2012: EuroIntervention
https://www.readbyqxmd.com/read/22022688/a-comparative-study-of-lingual-bracket-bond-strength
#11
COMPARATIVE STUDY
Luca Lombardo, Andrea Kaplan, Roberto Lapenta, Elena Bratti, Claudia Pera, Giuseppe Scuzzo, Giuseppe Siciliani
AIM: To compare the adhesive potential, the mechanics implicated in adhesive failure, and the effect on the enamel of four brands of lingual brackets. METHODS: One hundred sixty premolars and four types of commercially available lingual brackets (STB, ORG, Magic, and Stealth) were selected. Forty brackets per manufacturer were used, half bonded directly and half indirectly. Each of these bonding groups was further subdivided: 10 brackets were bonded without treatment, while the other 10 were sandblasted...
2011: Orthodontics: the Art and Practice of Dentofacial Enhancement
https://www.readbyqxmd.com/read/21473502/image-rehab-a-world-famous-rehabilitation-center-strengthens-its-brand-by-redifining-its-future
#12
Jorge Orozco, Mindy Aisen, Aries Limbaga, Diane Waskul, Greg Waskul
No abstract text is available yet for this article.
2011: Marketing Health Services
https://www.readbyqxmd.com/read/21297633/meta-analysis-identifies-29-additional-ulcerative-colitis-risk-loci-increasing-the-number-of-confirmed-associations-to-47
#13
Carl A Anderson, Gabrielle Boucher, Charlie W Lees, Andre Franke, Mauro D'Amato, Kent D Taylor, James C Lee, Philippe Goyette, Marcin Imielinski, Anna Latiano, Caroline Lagacé, Regan Scott, Leila Amininejad, Suzannah Bumpstead, Leonard Baidoo, Robert N Baldassano, Murray Barclay, Theodore M Bayless, Stephan Brand, Carsten Büning, Jean-Frédéric Colombel, Lee A Denson, Martine De Vos, Marla Dubinsky, Cathryn Edwards, David Ellinghaus, Rudolf S N Fehrmann, James A B Floyd, Timothy Florin, Denis Franchimont, Lude Franke, Michel Georges, Jürgen Glas, Nicole L Glazer, Stephen L Guthery, Talin Haritunians, Nicholas K Hayward, Jean-Pierre Hugot, Gilles Jobin, Debby Laukens, Ian Lawrance, Marc Lémann, Arie Levine, Cecile Libioulle, Edouard Louis, Dermot P McGovern, Monica Milla, Grant W Montgomery, Katherine I Morley, Craig Mowat, Aylwin Ng, William Newman, Roel A Ophoff, Laura Papi, Orazio Palmieri, Laurent Peyrin-Biroulet, Julián Panés, Anne Phillips, Natalie J Prescott, Deborah D Proctor, Rebecca Roberts, Richard Russell, Paul Rutgeerts, Jeremy Sanderson, Miquel Sans, Philip Schumm, Frank Seibold, Yashoda Sharma, Lisa A Simms, Mark Seielstad, A Hillary Steinhart, Stephan R Targan, Leonard H van den Berg, Morten Vatn, Hein Verspaget, Thomas Walters, Cisca Wijmenga, David C Wilson, Harm-Jan Westra, Ramnik J Xavier, Zhen Z Zhao, Cyriel Y Ponsioen, Vibeke Andersen, Leif Torkvist, Maria Gazouli, Nicholas P Anagnou, Tom H Karlsen, Limas Kupcinskas, Jurgita Sventoraityte, John C Mansfield, Subra Kugathasan, Mark S Silverberg, Jonas Halfvarson, Jerome I Rotter, Christopher G Mathew, Anne M Griffiths, Richard Gearry, Tariq Ahmad, Steven R Brant, Mathias Chamaillard, Jack Satsangi, Judy H Cho, Stefan Schreiber, Mark J Daly, Jeffrey C Barrett, Miles Parkes, Vito Annese, Hakon Hakonarson, Graham Radford-Smith, Richard H Duerr, Séverine Vermeire, Rinse K Weersma, John D Rioux
Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1...
March 2011: Nature Genetics
https://www.readbyqxmd.com/read/21222506/the-cost-effectiveness-of-zoledronic-acid-5%C3%A2-mg-for-the-management-of-postmenopausal-osteoporosis-in-women-with-prior-fractures-evidence-from-finland-norway-and-the-netherlands
#14
R Akehurst, N Brereton, R Ariely, T Lusa, M Groot, P Foss, S Boonen
OBJECTIVE: This study was conducted to assess the cost effectiveness of zoledronic acid 5 mg as a first-line treatment for the secondary prevention of fragility fractures in women with postmenopausal osteoporosis in Finland, Norway and the Netherlands. METHODS: A discrete-event, individual-patient computer-simulation model was used to compare the cost effectiveness of zoledronic acid with that of basic treatment (calcium and vitamin D) and commonly prescribed bisphosphonates in postmenopausal women aged 50-80 years who have experienced one previous fracture and have a bone mineral density T-score of -2...
2011: Journal of Medical Economics
https://www.readbyqxmd.com/read/21102463/genome-wide-meta-analysis-increases-to-71-the-number-of-confirmed-crohn-s-disease-susceptibility-loci
#15
Andre Franke, Dermot P B McGovern, Jeffrey C Barrett, Kai Wang, Graham L Radford-Smith, Tariq Ahmad, Charlie W Lees, Tobias Balschun, James Lee, Rebecca Roberts, Carl A Anderson, Joshua C Bis, Suzanne Bumpstead, David Ellinghaus, Eleonora M Festen, Michel Georges, Todd Green, Talin Haritunians, Luke Jostins, Anna Latiano, Christopher G Mathew, Grant W Montgomery, Natalie J Prescott, Soumya Raychaudhuri, Jerome I Rotter, Philip Schumm, Yashoda Sharma, Lisa A Simms, Kent D Taylor, David Whiteman, Cisca Wijmenga, Robert N Baldassano, Murray Barclay, Theodore M Bayless, Stephan Brand, Carsten Büning, Albert Cohen, Jean-Frederick Colombel, Mario Cottone, Laura Stronati, Ted Denson, Martine De Vos, Renata D'Inca, Marla Dubinsky, Cathryn Edwards, Tim Florin, Denis Franchimont, Richard Gearry, Jürgen Glas, Andre Van Gossum, Stephen L Guthery, Jonas Halfvarson, Hein W Verspaget, Jean-Pierre Hugot, Amir Karban, Debby Laukens, Ian Lawrance, Marc Lemann, Arie Levine, Cecile Libioulle, Edouard Louis, Craig Mowat, William Newman, Julián Panés, Anne Phillips, Deborah D Proctor, Miguel Regueiro, Richard Russell, Paul Rutgeerts, Jeremy Sanderson, Miquel Sans, Frank Seibold, A Hillary Steinhart, Pieter C F Stokkers, Leif Torkvist, Gerd Kullak-Ublick, David Wilson, Thomas Walters, Stephan R Targan, Steven R Brant, John D Rioux, Mauro D'Amato, Rinse K Weersma, Subra Kugathasan, Anne M Griffiths, John C Mansfield, Severine Vermeire, Richard H Duerr, Mark S Silverberg, Jack Satsangi, Stefan Schreiber, Judy H Cho, Vito Annese, Hakon Hakonarson, Mark J Daly, Miles Parkes
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP...
December 2010: Nature Genetics
https://www.readbyqxmd.com/read/21073734/functional-treatment-versus-plaster-for-simple-elbow-dislocations-funcsie-a-randomized-trial
#16
RANDOMIZED CONTROLLED TRIAL
Jeroen de Haan, Dennis den Hartog, Wim E Tuinebreijer, Gijs I T Iordens, Roelf S Breederveld, Maarten W G A Bronkhorst, Milko M M Bruijninckx, Mark R De Vries, Boudewijn J Dwars, Denise Eygendaal, Robert Haverlag, Sven A G Meylaerts, Jan-Willem R Mulder, Kees J Ponsen, W Herbert Roerdink, Gert R Roukema, Inger B Schipper, Michel A Schouten, Jan Bernard Sintenie, Senail Sivro, Johan G H Van den Brand, Hub G W M Van der Meulen, Tom P H Van Thiel, Arie B Van Vugt, Egbert J M M Verleisdonk, Jos P A M Vroemen, Marco Waleboer, W Jaap Willems, Suzanne Polinder, Peter Patka, Esther M M van Lieshout, Niels W L Schep
BACKGROUND: Elbow dislocations can be classified as simple or complex. Simple dislocations are characterized by the absence of fractures, while complex dislocations are associated with fractures. After reduction of a simple dislocation, treatment options include immobilization in a static plaster for different periods of time or so-called functional treatment. Functional treatment is characterized by early active motion within the limits of pain with or without the use of a sling or hinged brace...
2010: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/20622878/genome-wide-association-study-identifies-variants-in-the-mhc-class-i-il10-and-il23r-il12rb2-regions-associated-with-beh%C3%A3-et-s-disease
#17
Elaine F Remmers, Fulya Cosan, Yohei Kirino, Michael J Ombrello, Neslihan Abaci, Colleen Satorius, Julie M Le, Barbara Yang, Benjamin D Korman, Aris Cakiris, Oznur Aglar, Zeliha Emrence, Hulya Azakli, Duran Ustek, Ilknur Tugal-Tutkun, Gulsen Akman-Demir, Wei Chen, Christopher I Amos, Michael B Dizon, Afet Akdag Kose, Gulsevim Azizlerli, Burak Erer, Oliver J Brand, Virginia G Kaklamani, Phaedon Kaklamanis, Eldad Ben-Chetrit, Miles Stanford, Farida Fortune, Marwen Ghabra, William E R Ollier, Young-Hun Cho, Dongsik Bang, John O'Shea, Graham R Wallace, Massimo Gadina, Daniel L Kastner, Ahmet Gül
Behçet's disease is a genetically complex disease of unknown etiology characterized by recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed a genome-wide association study with 311,459 SNPs in 1,215 individuals with Behçet's disease (cases) and 1,278 healthy controls from Turkey. We confirmed the known association of Behçet's disease with HLA-B*51 and identified a second, independent association within the MHC Class I region. We also identified an association at IL10 (rs1518111, P = 1...
August 2010: Nature Genetics
https://www.readbyqxmd.com/read/20483851/the-counterfeit-self-the-deceptive-costs-of-faking-it
#18
Francesca Gino, Michael I Norton, Dan Ariely
Although people buy counterfeit products to signal positive traits, we show that wearing counterfeit products makes individuals feel less authentic and increases their likelihood of both behaving dishonestly and judging others as unethical. In four experiments, participants wore purportedly fake or authentically branded sunglasses. Those wearing fake sunglasses cheated more across multiple tasks than did participants wearing authentic sunglasses, both when they believed they had a preference for counterfeits (Experiment 1a) and when they were randomly assigned to wear them (Experiment 1b)...
May 2010: Psychological Science
https://www.readbyqxmd.com/read/19758907/the-syntax-score-an-angiographic-tool-grading-the-complexity-of-coronary-artery-disease
#19
Georgios Sianos, Marie-Angèle Morel, Arie Pieter Kappetein, Marie-Claude Morice, Antonio Colombo, Keith Dawkins, Marcel van den Brand, Nic Van Dyck, Mary E Russell, Friedrich W Mohr, Patrick W Serruys
No abstract text is available yet for this article.
August 2005: EuroIntervention
https://www.readbyqxmd.com/read/19577983/assessment-of-the-syntax-score-in-the-syntax-study
#20
Patrick W Serruys, Yoshinobu Onuma, Scot Garg, Giovanna Sarno, Marcel van den Brand, Arie-Pieter Kappetein, Nic Van Dyck, Michael Mack, David Holmes, Ted Feldman, Marie-Claude Morice, Antonio Colombo, Eric Bass, Katrin Leadley, Keith D Dawkins, Gerrit-Anne van Es, Marie-Angèle M Morel, Friedrich W Mohr
AIMS: The SYNTAX score has been designed to better anticipate the risks of percutaneous or surgical revascularisation, taking into account the functional impact of the coronary circulation with all its anatomic components including the presence of bifurcations, total occlusions, thrombus, calcification, and small vessels. The purpose of this paper is to describe the baseline assessment of the SYNTAX score in the Syntax randomised trial, the corelab reproducibility, the potential difference in score assessment between the investigator and the corelab, and to ascertain the impact on one-year outcome after either percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG) in patients with complex coronary artery disease...
May 2009: EuroIntervention
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