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Perilipin

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https://www.readbyqxmd.com/read/27907035/exendin-4-inhibits-hepatic-lipogenesis-by-increasing-%C3%AE-catenin-signaling
#1
Mi Hae Seo, Jinmi Lee, Seok-Woo Hong, Eun-Jung Rhee, Se Eun Park, Cheol Young Park, Ki Won Oh, Sung Woo Park, Won-Young Lee
The aim of this study is to investigate whether the beneficial effect of exendin-4 on hepatic steatosis is mediated by β-catenin signaling. After the HepG2 human hepatoma cells were treated with PA for 24 hours, total triglycerides levels were increased in a dose-dependent manner, and the expression levels of perilipin family members were upregulated in cells treated with 400 μM PA. For our in vitro model of hepatic steatosis, HepG2 cells were treated with 400 μM palmitic acid (PA) in the presence or absence of 100 nM exendin-4 for 24 hours...
2016: PloS One
https://www.readbyqxmd.com/read/27887615/developing-a-set-of-strong-intronic-promoters-for-robust-metabolic-engineering-in-oleaginous-rhodotorula-rhodosporidium-yeast-species
#2
Yanbin Liu, Sihui Amy Yap, Chong Mei John Koh, Lianghui Ji
BACKGROUND: Red yeast species in the Rhodotorula/Rhodosporidium genus are outstanding producers of triacylglyceride and cell biomass. Metabolic engineering is expected to further enhance the productivity and versatility of these hosts for the production of biobased chemicals and fuels. Promoters with strong activity during oil-accumulation stage are critical tools for metabolic engineering of these oleaginous yeasts. RESULTS: The upstream DNA sequences of 6 genes involved in lipid biosynthesis or accumulation in Rhodotorula toruloides were studied by luciferase reporter assay...
November 25, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27870476/the-perilipin-like-ppe15-protein-in-mycobacterium-tuberculosis-is-required-for-triacylglycerol-accumulation-under-dormancy-inducing-conditions
#3
Jaiyanth Daniel, Nidhi Kapoor, Tatiana Sirakova, Rajesh Sinha, Pappachan Kolattukudy
No abstract text is available yet for this article.
November 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27867269/platyphylloside-isolated-from-betula-platyphylla-inhibit-adipocyte-differentiation-and-induce-lipolysis-via-regulating-adipokines-including-ppar%C3%AE-in-3t3-l1-cells
#4
Mina Lee, Sang Hyun Sung
BACKGROUND: Obesity causes or aggravates many health problems, both independently and in association with several pathological disorders, including Type II diabetes, hypertension, atherosclerosis, and cancer. Therefore, we screened small compounds isolated from natural products for the development of anti-obesity drugs. OBJECTIVE: The purpose of this study was to investigate the anti-adipogenic activities of platyphylloside, diarylheptanoid isolated from Betula platyphylla, which was selected based on the screening using 3T3-L1 cells...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27862950/region-specific-effects-of-oestradiol-on-adipose-derived-stem-cell-differentiation-in-post-menopausal-women
#5
Kimberly A Cox-York, Christopher B Erickson, Rocio I Pereira, Daniel H Bessesen, Rachael E Van Pelt
The goal of this study was to determine the effect of acute transdermal 17β-oestradiol (E2 ) on the adipogenic potential of subcutaneous adipose-derived stem cells (ASC) in post-menopausal women. Post-menopausal women (n = 11; mean age 57 ± 4.5 years) were treated for 2 weeks, in a randomized, cross-over design, with transdermal E2 (0.15 mg) or placebo patches. Biopsies of abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) were obtained after each treatment and mature adipocytes were analysed for cell size and ASC for their capacity for proliferation (growth rate), differentiation (triglyceride accumulation) and susceptibility to tumour necrosis factor alpha-induced apoptosis...
November 15, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27832861/perilipin-1-binds-to-aquaporin-7-in-human-adipocytes-and-controls-its-mobility-via-protein-kinase-a-mediated-phosphorylation
#6
Jesper S Hansen, Christian Krintel, Malin Hernebring, Tatu J K Haataja, Sofia de Marè, Sebastian Wasserstrom, Urszula Kosinska-Eriksson, Madelene Palmgren, Cecilia Holm, Karin G Stenkula, Helena A Jones, Karin Lindkvist-Petersson
Accumulating evidence suggests that dysregulated glycerol metabolism contributes to the pathophysiology of obesity and type 2 diabetes. Glycerol efflux from adipocytes is regulated by the aquaglyceroporin AQP7, which is translocated upon hormone stimulation. Here, we propose a molecular mechanism where the AQP7 mobility in adipocytes is dependent on perilipin 1 and protein kinase A. Biochemical analyses combined with ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation...
December 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27821416/commentary-on-exposure-to-tumescent-solution-significantly-increases-phosphorylation-of-perilipin-in-adipocytes
#7
Steven R Cohen
No abstract text is available yet for this article.
November 7, 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27815650/development-of-a-three-dimensional-adipose-tissue-model-for-studying-embryonic-exposures-to-obesogenic-chemicals
#8
Rebecca Y Wang, Rosalyn D Abbott, Adam Zieba, Francis E Borowsky, David L Kaplan
Obesity is a rising issue especially in the United States that can lead to heart problems, type II diabetes, and respiratory problems. Since the 1970s, obesity rates in the United States have more than doubled in adults and children. Recent evidence suggests that exposure to certain chemicals, termed "obesogens," in utero may alter metabolic processes, predisposing individuals to weight gain. There is a need to develop a three-dimensional human tissue system that is able to model the effects of obesogens in vitro in order to better understand the impact of obesogens on early development...
November 4, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27734104/effects-of-insulin-induced-hypoglycaemia-on-lipolysis-rate-lipid-oxidation-and-adipose-tissue-signalling-in-human-volunteers-a-randomised-clinical-study
#9
Thomas S Voss, Mikkel H Vendelbo, Ulla Kampmann, Steen B Pedersen, Thomas S Nielsen, Mogens Johannsen, Mads V Svart, Niels Jessen, Niels Møller
AIMS/HYPOTHESIS: The aims of this study were to determine the role of lipolysis in hypoglycaemia and define the underlying intracellular mechanisms. METHODS: Nine healthy volunteers were randomised to treatment order of three different treatments (crossover design). Treatments were: (1) saline control; (2) hyperinsulinaemic hypoglycaemia (HH; i.v. bolus of 0.1 U/kg insulin); and (3) hyperinsulinaemic euglycaemia (HE; i.v. bolus of 0.1 U/kg insulin and 20% glucose)...
October 12, 2016: Diabetologia
https://www.readbyqxmd.com/read/27694818/reduced-lipolysis-response-to-adipose-afferent-reflex-involved-in-impaired-activation-of-adrenoceptor-camp-pka-hormone-sensitive-lipase-pathway-in-obesity
#10
Lei Ding, Feng Zhang, Ming-Xia Zhao, Xing-Sheng Ren, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Chemical stimulation of white adipose tissue (WAT) causes adipose afferent reflex (AAR) and sympathetic activation. This study is to investigate the effects of AAR on lipolysis and the mechanisms of attenuated lipolysis response to enhanced AAR in obesity. Obesity was caused by high-fat diet for 12 weeks in rats. AAR was induced by injection of capsaicin into inguinal WAT or electrical stimulation of epididymal WAT afferent nerve. AAR caused sympathetic activation, which was enhanced in obesity rats. AAR increased cAMP levels and PKA activity, promoted hormone sensitive lipase (HSL) and perilipin phosphorylation, and increased lipolysis in WAT, which were attenuated in obesity rats...
October 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27692709/effect-of-a-long-chain-n-3-polyunsaturated-fatty-acid-enriched-diet-on-adipose-tissue-lipid-profiles-and-gene-expression-in-holstein-dairy-cows
#11
Sebastien Elis, Alice Desmarchais, Sandrine Freret, Virginie Maillard, Valérie Labas, Juliette Cognié, Eric Briant, Celine Hivelin, Joëlle Dupont, Svetlana Uzbekova
The objective of this study was to determine whether fish oil supplement has an effect on adipose tissue lipid profiles and gene expression in postpartum dairy cows. Holstein cows were supplemented with either long-chain n-3 polyunsaturated fatty acid (PUFA; protected fish oil) or control PUFA (n-6; toasted soybeans) for 2 mo after calving (n = 23 per diet). These cows showed no difference in milk production or metabolic parameters, but exhibited a tendency toward a decrease in early embryo mortality rate after artificial insemination...
September 28, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27679530/perilipin-2-deletion-impairs-hepatic-lipid-accumulation-by-interfering-with-sterol-regulatory-element-binding-protein-srebp-activation-and-altering-the-hepatic-lipidome
#12
Andrew E Libby, Elise Bales, David J Orlicky, James L McManaman
Perilipin-2 (PLIN2) is a constitutively associated cytoplasmic lipid droplet coat protein that has been implicated in fatty liver formation in non-alcoholic fatty liver disease. Mice with or without whole-body deletion of perilipin-2 (Plin2-null) were fed either Western or control diets for 30 weeks. Perilipin-2 deletion prevents obesity and insulin resistance in Western diet-fed mice and dramatically reduces hepatic triglyceride and cholesterol levels in mice fed Western or control diets. Gene and protein expression studies reveal that PLIN2 deletion suppressed SREBP-1 and SREBP-2 target genes involved in de novo lipogenesis and cholesterol biosynthetic pathways in livers of mice on either diet...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27667512/epimedium-koreanum-nakai-and-its-main-constituent-icariin-suppress-lipid-accumulation-during-adipocyte-differentiation-of-3t3-l1-preadipocytes
#13
Yunk-Yung Han, Mi-Young Song, Min-Sub Hwang, Ji-Hye Hwang, Yong-Ki Park, Hyo-Won Jung
Obesity is associated with a number of metabolic abnormalities such as type 2 diabetes and has become a major health problem worldwide. In the present study, we investigated the effects of Epimedium koreanum Nakai (Herba Epimedii, HE) and its main constituent icariin on the adipocyte differentiation in 3T3-L1 preadipocytes. HE extract and icariin significantly reduced lipid accumulation and suppressed the expressions of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes. They also inhibited fatty acid synthase (FAS), acyl-Co A synthase (ACS1), and perilipin...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27659144/perilipin-2-and-age-related-metabolic-diseases-a-new-perspective
#14
Maria Conte, Claudio Franceschi, Marco Sandri, Stefano Salvioli
Perilipin 2 (Plin2), a protein associated with the metabolism of intracellular lipid droplets (LDs), has long been considered only for its role in lipid storage. However, the manipulation of its expression affects the severity of a variety of metabolic and age-related diseases, such as fatty liver, insulin resistance and type 2 diabetes (T2D), cardiovascular disease, atherosclerosis, sarcopenia, and cancer, suggesting that this protein may play a role in these pathological conditions. In particular, its downregulation in mice prevents or mitigates some of the above mentioned diseases...
September 19, 2016: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/27646609/perilipin-1-is-a-highly-specific-marker-for-adipocytic-differentiation-in-sarcomas-with-intermediate-sensitivity
#15
Christina C Westhoff, Janice Mrozinski, Ina Riedel, Hans W Heid, Roland Moll
PURPOSE: Liposarcomas are the most common soft tissue sarcomas of adults. The identification of lipoblastic cells in soft tissue sarcomas is mandatory for the diagnosis of most subtypes of liposarcomas but may be difficult in conventional histology. The present study focuses on the expression and possible diagnostic impact of two PAT family proteins, perilipin 1/perilipin and perilipin 2/adipophilin in human liposarcomas. METHODS: Eighty-seven cases of liposarcomas and 30 cases of non-lipomatous sarcomas were investigated immunohistochemically for perilipin 1 and 2 using entire tissue sections...
September 19, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27640183/erythropoietin-does-not-activate-erythropoietin-receptor-signaling-or-lipolytic-pathways-in-human-subcutaneous-white-adipose-tissue-in-vivo
#16
Britt Christensen, Birgitte Nellemann, Jens Otto L Jørgensen, Steen B Pedersen, Niels Jessen
BACKGROUND: Erythropoietin (Epo) exerts direct effects on white adipose tissue (WAT) in mice in addition to its erythropoietic effects, and in humans Epo increases resting energy expenditure and affect serum lipid levels, but direct effects of Epo in human WAT have not been documented. We therefore investigated the effects of acute and prolonged Epo exposure on human WAT in vivo. METHOD: Data were obtained from two clinical trials: 1) acute Epo exposure (rHuEpo, 400 IU/kg) followed by WAT biopsies after 1 h and 2) 10 weeks treatment with the erythropoiesis-stimulating agent (ESA) Darbepoietin-alpha...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27627109/regulation-of-lipolysis-and-adipose-tissue-signaling-during-acute-endotoxin-induced-inflammation-a-human-randomized-crossover-trial
#17
Nikolaj Rittig, Ermina Bach, Henrik Holm Thomsen, Steen Bønlykke Pedersen, Thomas Sava Nielsen, Jens O Jørgensen, Niels Jessen, Niels Møller
BACKGROUND: Lipolysis is accelerated during the acute phase of inflammation, a process being regulated by pro-inflammatory cytokines (e.g. TNF-α), stress-hormones, and insulin. The intracellular mechanisms remain elusive and we therefore measured pro- and anti-lipolytic signaling pathways in adipocytes after in vivo endotoxin exposure. METHODS: Eight healthy, lean, male subjects were investigated using a randomized cross over trial with two interventions: i) bolus injection of saline (Placebo) and ii) bolus injection of lipopolysaccharide endotoxin (LPS)...
2016: PloS One
https://www.readbyqxmd.com/read/27616431/effects-of-fatty-acid-transport-protein-1-on-proliferation-and-differentiation-of-porcine-intramuscular-preadipocytes
#18
Xiaoling Chen, Yanliu Luo, Ruisheng Wang, Bo Zhou, Zhiqing Huang, Gang Jia, Hua Zhao, Guangmang Liu
Fatty acid transport protein 1 (FATP1) plays an important role in the fatty acid transmembrane transport and fat deposition. However, its role in porcine intramuscular preadipocytes proliferation and differentiation remain poorly understood. Here, we examined the effects of pFATP1 on porcine intramuscular preadipocytes proliferation and differentiation. Overexpression of pFATP1 in porcine intramuscular preadipocytes significantly promoted the proliferation of porcine intramuscular preadipocytes, and also significantly upregulated the expressions of peroxisome proliferator-activated receptor γ, CCAAT enhancer binding protein α, lipoprotein lipase, fatty acid synthetase and perilipin 1...
September 12, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27616206/endomyocardial-proteomic-signature-corresponding-to-the-response-of-patients-with-dilated-cardiomyopathy-to-immunoadsorption-therapy
#19
Gourav Bhardwaj, Marcus Dörr, Praveen Kumar Sappa, Sabine Ameling, Vishnu Dhople, Leif Steil, Karin Klingel, Klaus Empen, Daniel Beug, Uwe Völker, Stephan B Felix, Elke Hammer
: Dilated cardiomyopathy (DCM) is a disease of the myocardium with reduced left ventricular ejection fraction (LVEF). Cardiac autoantibodies (AAbs) play a causal role in the development and progression of DCM. Removal of AAbs using immunoadsorption (IA/IgG) has been shown as a therapeutic option to improve cardiac function. However, the response to therapy differs significantly among patients. The reasons for this variability are not completely understood. Hitherto, no potential biomarker is available to predict improvement of cardiac function after therapy accurately...
September 9, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27590869/exposure-to-tumescent-solution-significantly-increases-phosphorylation-of-perilipin-in-adipocytes
#20
Ilknur Keskin, Mustafa Sutcu, Hilal Eren, Mustafa Keskin
BACKGROUND: Lidocaine and epinephrine could potentially decrease adipocyte viability, but these effects have not been substantiated. The phosphorylation status of perilipin in adipocytes may be predictive of cell viability. Perilipin coats lipid droplets and restricts access of lipases; phospho-perilipin lacks this protective function. OBJECTIVES: The authors investigated the effects of tumescent solution containing lidocaine and epinephrine on the phosphorylation status of perilipin in adipocytes...
September 2, 2016: Aesthetic Surgery Journal
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