keyword
MENU ▼
Read by QxMD icon Read
search

Perilipin

keyword
https://www.readbyqxmd.com/read/29317465/perilipin-5-and-liver-fatty-acid-binding-protein-function-to-restore-quiescence-in-mouse-hepatic-stellate-cells
#1
Jianguo Lin, Shizhong Zheng, Alan D Attie, Mark P Keller, David A Bernlohr, William S Blaner, Elizabeth P Newberry, Nicholas O Davidson, Anping Chen
Hepatic stellate cell (HSC) activation occurs along with decreased Perilipin5 (Plin5) and liver fatty acid-binding protein (L-Fabp) expression and coincident lipid droplet (LD) depletion. Conversely, the activated phenotype is reversible in wild type (wt) HSCs upon forced expression of Plin5. Here we asked if L-Fabp expression is required for Plin5-mediated rescue of the quiescent phenotype. Lentiviral Plin5 transduction of passaged L-Fabp-/- HSCs failed to reverse activation markers or to restore lipogenic gene expression and LD formation...
January 9, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29248005/short-term-disuse-promotes-fatty-acid-infiltration-into-skeletal-muscle
#2
Allan F Pagano, Thomas Brioche, Coralie Arc-Chagnaud, Rémi Demangel, Angèle Chopard, Guillaume Py
BACKGROUND: Many physiological and/or pathological conditions lead to muscle deconditioning, a well-described phenomenon characterized by a loss of strength and muscle power mainly due to the loss of muscle mass. Fatty infiltrations, or intermuscular adipose tissue (IMAT), are currently well-recognized components of muscle deconditioning. Despite the fact that IMAT is present in healthy human skeletal muscle, its increase and accumulation are linked to muscle dysfunction. Although IMAT development has been largely attributable to inactivity, the precise mechanisms of its establishment are still poorly understood...
December 16, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29236794/qualitative-analysis-of-the-viability-of-autogenous-fat-grafts-grafted-in-different-environments-of-interstitial-pressure-preliminary-results-and-description-of-a-new-experimental-model-in-mini-pigs
#3
Eduardo Gustavo Pires de Arruda, Alexandre Mendonça Munhoz, Walter Matsumoto, Thiago Ueda, Renata de Almeida Coudry, Rolf Gemperli
PURPOSE: To evaluate the feasibility of an experimental model of autologous fat graft (AFG) in different interstitial pressure (IP) environments. METHODS: Three mini-pigs(Minipig-BR) with age of 8 months (weight: 25-30 kg) were used. AFG were collected from the bucal fat pad, and grafted in the intramuscular pocket (biceps femoralis muscle). IP model was based on a fusiform ressection followed by primary closure "under tension". A blood pressure catheter located in the intramuscular region connected to a pressure module was applied to quantify IP...
November 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29217197/effect-of-lncrna-hoxa11-as1-on-adipocyte-differentiation-in-human-adipose-derived-stem-cells
#4
Nuerbiye Nuermaimaiti, Jie Liu, Xiaodi Liang, Yi Jiao, Dan Zhang, Ling Liu, Xuanyu Meng, Yaqun Guan
AIMS: To determine the role of lncRNA HOXA11-AS1 on adipocyte differentiation. METHODS: Human adipose-derived stem cells (hADSCs) were isolated from adipose tissues of patients and cultured in vitro, followed by knockdown of HOXA11-AS1. Then, adipocyte differentiation and expression of adipogenic-related genes (CEBP-α, DGAT2, CIDEC, and perilipin) were measured by RT-qPCR and Western blot. RESULTS: We demonstrated that knockdown of HOXA11-AS1 inhibited adipocyte differentiation, leading to suppression of adipogenic-related gene (CEBP-α, DGAT2, CIDEC, and perilipin) transcription, as well as decreased lipid accumulation in hADSCs...
December 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29215758/plin5-deficiency-promotes-atherosclerosis-progression-through-accelerating-inflammation-apoptosis-and-oxidative-stress
#5
Peng-Li Zhou, Min Li, Xin-Wei Han, Yong-Hua Bi, Wen-Guang Zhang, Zheng-Yang Wu, Gang Wu
Excessive plasma triglyceride and cholesterol levels promote the progression of several prevalent cardiovascular risk factors, including atherosclerosis, which is a leading death cause. Perilipin 5 (Plin5), an important perilipin protein, is abundant in tissues with very active lipid catabolism, and is involved in the regulation of oxidative stress. Although, in?ammation and oxidative stress play a critical role in atherosclerosis development, the underlying mechanisms are complex and not completely understood...
December 7, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29191637/spontaneous-development-of-hepatosteatosis-in-perilipin-1-null-mice-with-adipose-tissue-dysfunction
#6
Suning Wei, Shangxin Liu, Xueying Su, Weiyi Wang, Fengjuan Li, Jingna Deng, Ying Lyu, Bin Geng, Guoheng Xu
Fatty liver features triglyceride accumulation in hepatocytes and often occurs with obesity and lipodystrophy in humans. Here, we investigated the mechanism of maladaptive hepatosteatosis with adipose-tissue dysfunction. Perilipin 1 (Plin1) did not exist in hepatocytes but was expressed exclusively in adipocytes as a dual modulator for regulating two principal adipose-tissue functions, triglyceride storage and breakdown. Plin1-/- mice showed decreased fat storage but increased lipolysis and efflux of fatty acids from adipose tissue, and hepatosteatosis spontaneously developed without altered circulating inflammatory adipocytokine levels...
November 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29191221/increased-synovial-lipodystrophy-induced-by-high-fat-diet-aggravates-synovitis-in-experimental-osteoarthritis
#7
Ane Larrañaga-Vera, Ana Lamuedra, Sandra Pérez-Baos, Ivan Prieto-Potin, Leticia Peña, Gabriel Herrero-Beaumont, Raquel Largo
BACKGROUND: Metabolic syndrome (MetS) may be associated with knee osteoarthritis (OA), but the association between the individual components and OA are not well-understood. We aimed to study the effect of hypercholesterolemia on synovial inflammation in knee OA. METHODS: OA was surgically induced in rabbits fed with standard diet (OA group, n = 10) or in rabbits fed with high fat diet (OA-HFD, n = 10). Healthy rabbits receiving standard diet (Control, n = 10) or fed with HFD (HFD, n = 6) were also monitored...
December 1, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29181403/gosb-inhibits-triacylglycerol-synthesis-and-promotes-cell-survival-in-mouse-mammary-epithelial-cells
#8
Gaoxiao Xu, Saixing Duan, Jianye Hou, Zhongxin Wei, Guangwei Zhao
It has been demonstrated that the activator protein related transcription factor Finkel-Biskis-Jinkins murine osteosarcoma B (GosB) is involved in preadipocyte differentiation and triacylglycerol synthesis. However, the role of GosB in regulating the synthesis of milk fatty acid in mouse mammary glands remains unclear. This research uncovered potentially new roles of GosB in suppressing milk fatty acid synthesis. Results revealed that GosB had the highest expression in lung tissue and showed a higher expression level during nonlactation than during lactation...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29162103/phenolic-compounds-apigenin-hesperidin-and-kaempferol-reduce-in-vitro-lipid-accumulation-in-human-adipocytes
#9
Saioa Gómez-Zorita, Arrate Lasa, Naiara Abendaño, Alfredo Fernández-Quintela, Andrea Mosqueda-Solís, Maria Pilar Garcia-Sobreviela, Jose M Arbonés-Mainar, Maria P Portillo
BACKGROUND: Adipocytes derived from human mesenchymal stem cells (MSCs) are widely used to investigate adipogenesis. Taking into account both the novelty of these MSCs and the scarcity of studies focused on the effects of phenolic compounds, the aim of the present study was to analyze the effect of apigenin, hesperidin and kaempferol on pre-adipocyte and mature adipocytes derived from this type of cells. In addition, the expression of genes involved in TG accumulation was also measured...
November 21, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29155266/chronic-dexamethasone-exposure-markedly-decreased-the-hepatic-triglyceride-accumulation-in-growing-goats
#10
Qu Chen, Liqiong Niu, Canfeng Hua, Yali Geng, Liuping Cai, Shiyu Tao, Yingdong Ni, Ruqian Zhao
Chronic stress seriously threatens welfare and health in animals and humans. Consecutive dexamethasone (Dex) injection was used to mimic chronic stress previously. In order to investigate the effect of chronic stress on hepatic lipids metabolism, in this study, 10 healthy male goats were randomly allocated into two groups, one received a consecutive injection of Dex via intramuscularly for 3 weeks (Dex group), the other received the same volume of saline as the control group (Con group). Hepatic health and triglyceride (TG) metabolism were analyzed and compared between two groups...
November 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29152131/microrna-130b-attenuates-dexamethasone-induced-increase-of-lipid-accumulation-in-porcine-preadipocytes-by-suppressing-ppar-%C3%AE-expression
#11
Shifeng Pan, Yixin Cui, Xuan Dong, Tangjie Zhang, Hua Xing
In this study, two experiments were conducted to determine the role of miR-130b in dexamethasone (DEX)-induced lipid accumulation. Porcine preadipocytes were treated with 10(-6) M DEX for 48 h to investigate effects of DEX in lipid accumulation. Next, in order to illustrate the regulatory role of miR-130b on lipid accumulation induced by DEX, miRNA scrambled control (miR-SC), miR-130b overexpression plasmid and miR-130b inhibitor were respectively transfected into porcine preadipocytes at 24 h before DEX treatment for 48 h (miR-SC-DEX, miR-130b-DEX and miR-130b-inhibitor-DEX)...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29150696/impact-of-prolonged-overfeeding-on-skeletal-muscle-mitochondria-in-healthy-individuals
#12
Frederico G S Toledo, Darcy L Johannsen, Jeffrey D Covington, Sudip Bajpeyi, Bret Goodpaster, Kevin E Conley, Eric Ravussin
AIMS/HYPOTHESES: Reduced mitochondrial capacity in skeletal muscle has been observed in obesity and type 2 diabetes. In humans, the aetiology of this abnormality is not well understood but the possibility that it is secondary to the stress of nutrient overload has been suggested. To test this hypothesis, we examined whether sustained overfeeding decreases skeletal muscle mitochondrial content or impairs function. METHODS: Twenty-six healthy volunteers (21 men, 5 women, age 25...
November 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/29137982/adipose-tissue-complement-factor-b-promotes-adipocyte-maturation
#13
Hiroaki Matsunaga, Misaki Iwashita, Takanori Shinjo, Akiko Yamashita, Mitsudai Tsuruta, Shoichiro Nagasaka, Ataru Taniguchi, Mitsuo Fukushima, Naoya Watanabe, Fusanori Nishimura
OBJECTIVES: It is well-known that the complement system plays an essential role in host immunity. Observational studies have indicated that complement system-related molecules such as complement factor B (CfB) and other components are correlated with obesity and/or insulin resistance parameters. In this study, we investigated the role of adipocyte-derived CfB in adipose tissue metabolism. METHODS: We investigated the expression level of complement system-related genes in adipocytes...
November 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29118433/visualization-of-lipid-directed-dynamics-of-perilipin-1-in-human-primary-adipocytes
#14
Jesper S Hansen, Sofia de Maré, Helena A Jones, Olga Göransson, Karin Lindkvist-Petersson
Perilipin 1 is a lipid droplet coating protein known to regulate lipid metabolism in adipocytes by serving as a physical barrier as well as a recruitment site for lipases to the lipid droplet. Phosphorylation of perilipin 1 by protein kinase A rapidly initiates lipolysis, but the detailed mechanism on how perilipin 1 controls lipolysis is unknown. Here, we identify specific lipid binding properties of perilipin 1 that regulate the dynamics of lipolysis in human primary adipocytes. Cellular imaging combined with biochemical and biophysical analyses demonstrate that perilipin 1 specifically binds to cholesteryl esters, and that their dynamic properties direct segregation of perilipin 1 into topologically distinct micro domains on the lipid droplet...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118419/melatonin-promotes-triacylglycerol-accumulation-via-mt2-receptor-during-differentiation-in-bovine-intramuscular-preadipocytes
#15
Wucai Yang, Keqiong Tang, Yaning Wang, Yingying Zhang, Linsen Zan
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan which is produced and secreted mainly by the pineal gland and regulates a variety of important central and peripheral actions. To examine the potential effects of melatonin on the proliferation and differentiation of bovine intramuscular preadipocytes (BIPs), BIPs were incubated with different concentrations of melatonin. Melatonin supplementation at 1 mM significantly increased peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein (C/EBP) β, and C/EBPα expression and promoted the differentiation of BIPs into adipocytes with large lipid droplets and high cellular triacylglycerol (TAG) levels...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110300/dissociation-of-intramyocellular-lipid-storage-and-insulin-resistance-in-trained-athletes-and-type-2-diabetes-patients-involvement-of-perilipin-5
#16
Anne Gemmink, Sabine Daemen, Bram Brouwers, Peter R Huntjens, Gert Schaart, Esther Moonen-Kornips, Johanna Jörgensen, Joris Hoeks, Patrick Schrauwen, Matthijs K C Hesselink
Intramyocellular lipids (IMCL) hamper insulin sensitivity albeit not in endurance-trained athletes (Trained). Compared to type 2 diabetes patients (T2DM), Trained subjects have high levels of Perilipin 5 (PLIN5). Here, we tested if the fraction of PLIN5 coated LDs is a determinant of skeletal muscle insulin sensitivity and contributes to the athlete's paradox. Muscle biopsies were taken from 8 Trained, Lean sedentary, Obese and T2DM subjects. Trained, Obese and T2DM subjects were matched for total IMCL content...
November 7, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29102029/-tetrandrine-has-anti-adipogenic-effect-on-3t3-l1-preadipocytes-through-the-reduced-expression-and-or-phosphorylation-levels-of-c-ebp-%C3%AE-ppar-%C3%AE-fas-perilipin-a-and-stat-3-biochem-biophys-res-%C3%A2-commun-476-4-2016-481-486
#17
https://www.readbyqxmd.com/read/29094660/investigation-of-the-perilipin-5-gene-expression-and-association-study-of-its-sequence-polymorphism-with-meat-and-carcass-quality-traits-in-different-pig-breeds
#18
M Zappaterra, M Mazzoni, P Zambonelli, R Davoli
The growing request for healthier fatty acid composition of animal products is raising the necessity of a deeper knowledge of the main factors controlling fatty acids storage in muscle and backfat. Perilipin (PLIN) 5, and the whole Perilipin family, seem to play a crucial role in the regulation of lipids deposition as code for proteins coating intracellular lipid droplets surface. Nevertheless, the knowledge of these genes in pig is still incomplete. The present research was aimed at investigating in different pig breeds the PLIN5 gene, analysing its expression level and the associations of the variability in its downstream gene region with pork meat and carcass quality traits...
November 2, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29090233/common-variations-in-perilipin-rs1052700-and-fto-rs3751812-gene-variants-and-risk-for-obesity-and-type-2-diabetes
#19
Ramin Saravani, Hamid Reza Galavi, Nafiseh Noorzehi, Nasrin Ranjbar, Fatemeh Mollashahee-Kohkan
BACKGROUND: Perilipins are proteins that coat lipid globules in adipocytes, which are steroid-generating cells that play a central role in lipid storage and breakdown. The FTO gene is associated with type-2 diabetes (T2D) and increased fat mass. In this work the association of perilipin and FTO gene polymorphisms in T2D was investigated. METHODS: One hundred eighty-three Iranian men and women with T2D, and 174 healthy controls with no known metabolic diseases, participated in the study...
October 2017: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29066463/angiotensin-1-7-stimulates-brown-adipose-tissue-and-reduces-diet-induced-obesity
#20
Hidechika Morimoto, Jun Mori, Hisakazu Nakajima, Yasuhiro Kawabe, Yusuke Tsuma, Shota Fukuhara, Kazuki Kodo, Kazuya Ikoma, Satoaki Matoba, Gavin Y Oudit, Hajime Hosoi
The renin-angiotensin system is a key regulator of metabolism with beneficial effects of the angiotensin 1-7 peptide. We hypothesized that the anti-obesity effect of Ang 1-7 is related to the stimulation of brown adipose tissue (BAT). We administered Ang 1-7 (0.54 mg・kg-1・d-1) for 28 days via implanted micro-osmotic pumps to mice with high-fat diet (HFD) induced obesity. Ang 1-7 treatment reduced body weight, upregulated thermogenesis and ameliorated impaired glucose homeostasis without affecting food consumption...
October 24, 2017: American Journal of Physiology. Endocrinology and Metabolism
keyword
keyword
44116
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"