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Ilse Eidhof, Michaela Fenckova, Dei M Elurbe, Bart van de Warrenburg, Anna Castells Nobau, Annette Schenck
Advances in next-generation sequencing technologies contribute to the identification of (candidate) disease genes for movement disorders and other neurological diseases at an increasing speed. However, little is known about the molecular mechanisms that underlie these disorders. The genetic, molecular, and behavioral toolbox of Drosophila melanogaster makes this model organism particularly useful to characterize new disease genes and mechanisms in a high-throughput manner. Nevertheless, high-throughput screens require efficient and reliable assays that, ideally, are cost-effective and allow for the automatized quantification of traits relevant to these disorders...
November 5, 2017: Journal of Visualized Experiments: JoVE
Jean-Robert Likofata Esanga, Claire Viadro, Leah McManus, Jennifer Wesson, Nicaise Matoko, Epiphane Ngumbu, Kate E Gilroy, Daren Trudeau
The Democratic Republic of Congo has flagged health workforce management and compensation as issues requiring attention, including the problem of ghost workers (individuals on payroll who do not exist and/or show up at work). Recognising the need for reliable health workforce information, the government has worked to implement iHRIS, an open source human resources information system that facilitates health workforce management. In Kasaï Central and Kasaï Provinces, health workers brought relevant documentation to data collection points, where trained teams interviewed them and entered contact information, identification, photo, current job, and employment and education history into iHRIS on laptops...
November 1, 2017: Health Policy and Planning
Sven Schmutz, Andreas Sonderegger, Juergen Sauer
This study examined how implementing recommendations from Web accessibility guidelines affects nondisabled people in different age groups using different technical devices. While recent research showed positive effects of implementing such recommendations for nondisabled users, it remains unclear whether such effects would apply to different age groups and kind of devices. A 2x2x2 design was employed with website accessibility (high accessibility vs. very low accessibility), age (younger adults vs. older adults) and type of device (laptop vs...
November 14, 2017: Ergonomics
Gina P Angley, Jean Anne Schnittker, Anne Marie Tharpe
BACKGROUND: In an effort to reduce health-care disparities, there has been a recent surge of interest in the remote provision of care. Audiologists have begun to provide screening, diagnostic, and rehabilitative services via telehealth technologies. PURPOSE: To evaluate the feasibility and perceived benefits of providing remote hearing aid follow-up appointments in a controlled clinical environment and in participants' homes. RESEARCH DESIGN: A descriptive quasi-experimental study was completed...
November 2017: Journal of the American Academy of Audiology
Suvardhan Kanchi, Myalowenkosi I Sabela, Phumlane Selby Mdluli, Inamuddin, Krishna Bisetty
A smartphone is a facile, handy-analytical device that makes our lives comfortable and stress-free in terms of health care diagnostic assessments. Due to recent advancements in the technology and the introduction of user friendly operating systems and applications, the smartphones have replaced laptops and desktop computers. Taking this fact into account, researchers have designed sensing systems which are more compatible with smartphones. Consequently, these devices are attracting the attention of researchers from fields such as telemedicine, biotechnology, chemical sciences and environmental sciences...
November 6, 2017: Biosensors & Bioelectronics
Fritz J Sedlazeck, Andi Dhroso, Dale L Bodian, Justin Paschall, Farrah Hermes, Justin M Zook
The impact of structural variants (SVs) on a variety of organisms and diseases like cancer has become increasingly evident. Methods for SV detection when studying genomic differences across cells, individuals or populations are being actively developed. Currently, just a few methods are available to compare different SVs callsets, and no specialized methods are available to annotate SVs that account for the unique characteristics of these variant types. Here, we introduce SURVIVOR_ant, a tool that compares types and breakpoints for candidate SVs from different callsets and enables fast comparison of SVs to genomic features such as genes and repetitive regions, as well as to previously established SV datasets such as from the 1000 Genomes Project...
2017: F1000Research
Melinda A Meyer DeMott, Marianne Jakobsen, Tore Wentzel-Larsen, Trond Heir
This is the first controlled study of an expressive arts group intervention with unaccompanied minor asylum seeking children. The aim of the study was to examine whether such an intervention may alleviate symptoms of trauma and enhance life satisfaction and hope. One hundred forty five unaccompanied minor refugee boys with their stated age between 15 and 18 were allocated into a 10 session 5 weeks manualized expressive arts intervention (EXIT) or a life as usual (LAU) control group. The participants were assessed at onset and 4 times over a period of 25 months with a battery of instruments measuring post-traumatic stress symptoms (PTSS), general psychological distress (HSCL-25A), current life satisfaction (CLS) and expected life satisfaction (ELS)...
December 2017: Scandinavian Journal of Psychology
Yeshwanth Pulijala, Minhua Ma, Matthew Pears, David Peebles, Ashraf Ayoub
PURPOSE: Surgical training methods are evolving with the technological advancements, including the application of virtual reality (VR) and augmented reality. However, 28 to 40% of novice residents are not confident in performing a major surgical procedure. VR surgery, an immersive VR (iVR) experience, was developed using Oculus Rift and Leap Motion devices (Leap Motion, Inc, San Francisco, CA) to address this challenge. Our iVR is a multisensory, holistic surgical training application that demonstrates a maxillofacial surgical technique, the Le Fort I osteotomy...
October 13, 2017: Journal of Oral and Maxillofacial Surgery
Leon Straker, Courtenay Harris, John Joosten, Erin K Howie
This paper describes contemporary use of information technology devices by children in a socio-educationally advantaged school. A sample of 924 children (50% girls) from grades 5 to 12 (ages 10 to 19 years) completed an online survey in class. Total daily technology use was high and similar for girls and boys (mean 219(SD 148) mins/day; boys 207(142); t=-1.32; p=.186). Tablet computer was the dominant device used in grades 5 to 9, with laptop computer the dominant device in grades 10 to 12. Patterns of exposure were influenced by gender, device, grade and purpose of use interactions...
November 6, 2017: Ergonomics
María D Bovea, Valeria Ibáñez-Forés, Victoria Pérez-Belis, Pablo Juan
This study analyses the current habits and practices towards the store, repair and second-hand purchase of small electrical and electronic devices belonging to the category of information and communication technology (ICT). To this end, a survey was designed and conducted with a representative sample size of 400 individuals through telephone interviews for the following categories: MP3/MP4, video camera, photo camera, mobile phone, tablet, e-book, laptop, hard disk drive, navigator-GPS, radio/radio alarm clock...
November 1, 2017: Waste Management
Lu Zhao, Zhimin Liu, Sasha F Levy, Song Wu
Motivation: Barcode sequencing (bar-seq) is a high-throughput, and cost effective method to assay large numbers of cell lineages or genotypes in complex cell pools. Because of its advantages, applications for bar-seq are quickly growing - from using neutral random barcodes to study the evolution of microbes or cancer, to using pseudo-barcodes, such as shRNAs or sgRNAs to simultaneously screen large numbers of cell perturbations. However, the computational pipelines for bar-seq clustering are not well developed...
October 23, 2017: Bioinformatics
Najya A Attia, Lubna Baig, Yousef I Marzouk, Anwar Khan
BACKGROUND AND OBJECTIVES: In the present era, it is difficult to keep the concentration of college students at its maximum potential during the class time, as there are many distractions that negatively impact students' concentration and prevent optimal learning. Technologies such as laptops and cell phones have invaded the classroom, raising considerable concerns about their effects on college students' attention in the classroom. Despite these concerns, no research has been done in Saudi Arabia on the effects of technology and other types of classroom distractions on students' concentration...
July 2017: Pakistan Journal of Medical Sciences Quarterly
James C Yuen
Remote monitoring capability does not currently exist for Periflux (Perimed AB, Järfälla, Sweden) laser Doppler and other perfusion monitors. Two simple adaptations using free apps (applications) and smart devices can enable transmission of the perfusion readout to the surgeon's smartphone. A literature review was conducted to identify reports relating to remote free flap monitoring. In addition, 2 wireless methodologies are devised: One method uses a free app that converts a smart device into a camera, stationed next to the perfusion monitor, to stream live video of the laser Doppler readout to the surgeon's smartphone; a second method uses a free app installed on a bedside laptop computer, which is connected to the laser Doppler flowmeter via a data cord...
September 2017: Plastic and Reconstructive Surgery. Global Open
Michael T Shaw, Margaret Kasschau, Bryan Dobbs, Natalie Pawlak, William Pau, Kathleen Sherman, Marom Bikson, Abhishek Datta, Leigh E Charvet
The remotely supervised tDCS (RS-tDCS) protocol enables participation from home through guided and monitored self-administration of tDCS treatment while maintaining clinical standards. The current consensus regarding the efficacy of tDCS is that multiple treatment sessions are needed to observe targeted behavioral reductions in symptom burden. However, the requirement for patients to travel to clinic daily for stimulation sessions presents a major obstacle for potential participants, due to work or family obligations or limited ability to travel...
October 7, 2017: Journal of Visualized Experiments: JoVE
Mete Akgün, Hüseyin Demirci
Summary: The decreasing cost in high-throughput technologies led to a number of sequencing projects consisting of thousands of whole genomes. The paradigm shift from exome to whole genome brings a significant increase in the size of output files. Most of the existing tools which are developed to analyse exome files are not adequate for larger VCF files produced by whole genome studies. In this work we present VCF-Explorer, a variant analysis software capable of handling large files. Memory efficiency and avoiding computationally costly pre-processing step enable to carry out the analysis to be performed with ordinary computers...
November 1, 2017: Bioinformatics
Danfeng Yu, Qingbin Song, Zhishi Wang, Jinhui Li, Huabo Duan, Jinben Wang, Chao Wang, Xu Wang
The used electronic product (UEP) has attracted the worldwide attentions because part of e-waste may be exported from developed countries to developing countries in the name of UEP. On the basis of large foreign trade data of electronic products (e-products), this study adopted the trade data approach (TDA) to quantify the potential exports of UEP in Macau, taking a case study of personal computers (PCs). The results show that the desktop mainframes, LCD monitors, and CRT monitors have more low-unit-value trades with higher trade volumes in the past 10 years, while the laptop and tablet PCs, as the newer technologies, owned the higher ratios of the high-unit-value trades...
October 11, 2017: Environmental Science and Pollution Research International
Eyad Fawzi AlSaeed, Mutahir A Tunio
OBJECTIVES: We aimed to compare the dietary habits, engagement in various sports, smoking habits, marital status and other demographic characteristics, between cancer patients and healthy adults (control) at our institute, Riyadh, Saudi Arabia. PATIENTS AND METHODS: A cross-sectional descriptive study was conducted on 500 participants (237 cancer patients and 263 healthy adults). A well-structured questionnaire was given to these participants regarding the life style, dietary habits, and marital status through interviews...
September 2017: Gulf Journal of Oncology
B Rodriguez-Vila, P Sánchez-González, I Oropesa, E J Gomez, D M Pierce
We propose a fully automated methodology for hexahedral meshing of patient-specific structures of the human knee obtained from magnetic resonance images, i.e. femoral/tibial cartilages and menisci. We select eight patients from the Osteoarthritis Initiative and validate our methodology using MATLAB on a laptop computer. We obtain the patient-specific meshes in an average of three minutes, while faithfully representing the geometries with well-shaped elements. We hope to provide a fundamentally different means to test hypotheses on the mechanisms of disease progression by integrating our patient-specific FE meshes with data from individual patients...
October 10, 2017: Computer Methods in Biomechanics and Biomedical Engineering
Richard M Leggett, Matthew D Clark
Oxford Nanopore Technologies' MinION sequencer was launched in pre-release form in 2014 and represents an exciting new sequencing paradigm. The device offers multi-kilobase reads and a streamed mode of operation that allows processing of reads as they are generated. Crucially, it is an extremely compact device that is powered from the USB port of a laptop computer, enabling it to be taken out of the lab and facilitating previously impossible in-field sequencing experiments to be undertaken. Many of the initial publications concerning the platform focused on provision of tools to access and analyse the new sequence formats and then demonstrating the assembly of microbial genomes...
August 23, 2017: Journal of Experimental Botany
Anshu Priya, Subrata Hait
Metals liberation and composition are decisive attributes in characterization of e-waste for metal recycling. Though end-of-life printed circuit board (PCB) is an integral part of e-waste as secondary resource reservoir, yet no standardized procedure exists for metals liberation and dissolution for its characterization. Thus, the paper aims at assessment of metals liberation upon comminution employing scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) followed by comparative assessment of the existing United States Environmental Protection Agency (USEPA) digestion procedures, viz...
October 4, 2017: Environmental Science and Pollution Research International
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