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chronic regional pain syndrome

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https://www.readbyqxmd.com/read/29927949/snps-in-inflammatory-genes-ccl11-ccl4-and-mefv-in-a-fibromyalgia-family-study
#1
Zhifang Zhang, Jinong Feng, Allen Mao, Keith Le, Deirdre La Placa, Xiwei Wu, Jeffrey Longmate, Claudia Marek, R Paul St Amand, Susan L Neuhausen, John E Shively
BACKGROUND: Fibromyalgia (FM) is a chronic pain syndrome with a high incidence in females that may involve activation of the immune system. We performed exome sequencing on chemokine genes in a region of chromosome 17 identified in a genome-wide family association study. METHODS AND FINDINGS: Exome sequence analysis of 100 FM probands was performed at 17p13.3-q25 followed by functional analysis of SNPs found in the chemokine gene locus. Missense SNPs (413) in 17p13...
2018: PloS One
https://www.readbyqxmd.com/read/29925724/influence-of-regional-anesthesia-on-the-rate-of-chronic-postthoracotomy-pain-syndrome-in-lung-cancer-patients
#2
Victoria Khoronenko, Danil Baskakov, Marc Leone, Anna Malanova, Andrey Ryabov, Oleg Pikin, Maksim Golovashchenko
PURPOSE: Our study aimed to assess whether the type of regional anesthesia influenced the incidence of chronic postthoracotomy pain syndrome (CPTPS). METHODS: This was a prospective, randomized study that included 300 patients undergoing lung cancer resection using thoracotomy. They were randomized into three groups: paravertebral nerve block (PVB), thoracic epidural anesthesia (TEA), and intercostal nerve block (INB). General anesthesia was similar in the groups...
June 20, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29922495/arthroscopic-reduction-association-of-the-scapholunate-with-an-absorbable-screw
#3
João Torrinha Jorge, Ana Ferrão, Sandra Alves, Ruben Caetano, Frederico Teixeira
Background  The treatment of chronic scapholunate instability is yet a controversial topic. Arthroscopic reduction-association scapholunate technique is a minimally invasive option in which a stable pseudoarthrosis at the scapholunate joint is obtained, allowing some degree of movement while maintaining the normal alignment of the wrist. The purpose of this study was to review the results of arthroscopic reduction-association scapholunate with an absorbable screw. Methods  We retrospectively evaluated patients with dynamic or static, but reducible, chronic scapholunate instability who underwent arthroscopic reduction-association scapholunate between 2012 and 2015...
July 2018: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/29913923/national-guidelines-for-evaluating-pain-patients-legal-right-to-prioritised-health-care-at-multidisciplinary-pain-clinics-in-norway-implemented-2009
#4
Karen Walseth Hara, Petter Borchgrevink
Background All nations are posed with the challenge of deciding how to allocate limited health care resources. A Patients' Rights Law from 1999 gives patients in Norway with a serious health condition, for which there is efficacious and cost-effective treatment, a legal right to receive health care from the National Health Care system. Methods Recently national guidelines have been produced for implementing these legal rights within 32 fields of specialist health care. One of these fields deals with serious chronic pain conditions...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913713/spinal-cord-stimulation-background-and-clinical-application
#5
Kaare Meier
Background Spinal cord stimulation (SCS) is a surgical treatment for chronic neuropathic pain refractory to conventional treatment. SCS treatment consists of one or more leads implanted in the epidural space of the spinal canal, connected to an implantable pulse generator (IPG). Each lead carries a number of contacts capable of delivering a weak electrical current to the spinal cord, evoking a feeling of peripheral paresthesia. With correct indication and if implanted by an experienced implanter, success rates generally are in the range of about 50-75%...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913678/female-chronic-pelvic-pain-is-highly-prevalent-in-denmark-a-cross-sectional-population-based-study-with-randomly-selected-participants
#6
S Loving, T Thomsen, P Jaszczak, J Nordling
Background and purpose Female chronic pelvic pain is a significant clinical problem that burdens the health care services and work productivity, and leads to disability and reduced quality of life among the women affected. A recent systematic review reported worldwide prevalence rates for female chronic pelvic pain ranging from 2.1% to 24%. Our aim was to assess the prevalence, characteristics, and factors associated with chronic pelvic pain among women living in Denmark, and to compare these findings with a pain-free reference group...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913636/mirror-therapy-for-complex-regional-pain-syndrome-crps-a-literature-review-and-an-illustrative-case-report
#7
Samaa Al Sayegh, Tove Filén, Mats Johansson, Susanne Sandström, Gisela Stiewe, Stephen Butler
Background and purpose This case of a 42 year old woman with lower extremity Complex Regional Pain Syndrome (CRPS) after a twisting injury of the ankle, effectively treated with the addition of mirror therapy to a rehabilitation programme, prompted a literature review of both CRPS and mirror therapy. Mirror therapy is a newer adjunct to other forms of pain control and functional restoration for treatment of CRPS as well as other difficult clinical problems. This was a required group project as part of a university based course in chronic pain for healthcare workers...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911652/building-the-evidence-for-crps-research-from-a-lived-experience-perspective
#8
Colleen M Johnston, Florin I Oprescu, Marion Gray
Background and aims Pain is known to be a subjective experience yet the majority of pain related research does not address the lived experience of the condition. Difficult to diagnose, Complex Regional Pain Syndrome (CRPS) is often poorly managed. The aim of this paper was to identify and synthesise the currently available literature on experiences of living with chronic pain in order to understand where and how CRPS research may be best situated in the future. Methods A narrative review was performed and ProQuest, EBSCO, Informit, Scopus/Science Direct and Web of Science, Medline, CINHAL and Google Scholar were searched in order to identify the literature from 1998 until 2015...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29896150/recovery-of-repressed-memories-in-fibromyalgia-patients-treated-with-hyperbaric-oxygen-case-series-presentation-and-suggested-bio-psycho-social-mechanism
#9
Shai Efrati, Amir Hadanny, Shir Daphna-Tekoah, Yair Bechor, Kobi Tiberg, Nimrod Pik, Gil Suzin, Rachel Lev-Wiesel
Fibromyalgia Syndrome (FMS) is a condition considered to represent a prototype of central sensitization syndrome, characterized by chronic widespread pain and along with symptoms of fatigue, non-restorative sleep and cognitive difficulties. FMS can be induced by trauma, infection or emotional stress with cumulative evidence that dissociation is relatively frequent in FMS patients. Two randomized controlled trials have shown that hyperbaric oxygen therapy (HBOT) can induce neuroplasticity and be effective in patients suffering from FMS...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29881952/-what-rheumatologists-can-learn-from-ophthalmologists
#10
REVIEW
M D Becker, R Max, A Dimitriou, T Saurenmann, H-M Lorenz, A Jansen, S Lortz, J Grulich-Henn, M Weber
Intraocular inflammation with the imprecise and broad umbrella term "uveitis" is a diagnostic and therapeutic challenge in ophthalmology. Uveitis is one of the most common causes of blindness worldwide and due to the associated costs is comparable to diabetic retinopathy. Patients can be affected by uveitis at any age. Any part of the eye may be affected. The symptoms range from complete absence of symptoms, through all types of vision deterioration up to a red and even very painful eye. Uveitis can be strictly unilateral (also alternating from the left to the right eye) or bilateral with a relapsing or chronic course...
June 7, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29875641/an-integrative-neuroscience-framework-for-the-treatment-of-chronic-pain-from-cellular-alterations-to-behavior
#11
Jess D Greenwald, Keith M Shafritz
Chronic pain can result from many pain syndromes including complex regional pain syndrome (CRPS), phantom limb pain and chronic low back pain, among others. On a molecular level, chronic pain syndromes arise from hypersensitization within the dorsal horn of the spinal cord, a process known as central sensitization. Central sensitization involves an upregulation of ionotropic and metabotropic glutamate receptors (mGluRs) similar to that of long-term potentiation (LTP). Regions of the brain in which LTP occurs, such as the amygdala and hippocampus, are implicated in fear- and memory-related brain circuity...
2018: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29871376/functional-connectivity-alterations-novel-therapy-and-future-implications-in-chronic-pain-management
#12
Stephen L Thorp, Thomas Suchy, Nalini Vadivelu, Erik M Helander, Richard D Urman, Alan D Kaye
BACKGROUND: Chronic pain is a major public health problem resulting in physical and emotional pain for individuals and families, loss of productivity, and an annual cost of billions of dollars. The lack of objective measures available to aid in diagnosis and evaluation of therapies for chronic pain continues to be a challenge for the clinician. OBJECTIVES: Functional magnetic resonance imaging (fMRI) is an imaging technique that can establish regional areas of interest and examine synchronous neuronal activity in functionally related but anatomically distinct regions of the brain, known as functional connectivity...
May 2018: Pain Physician
https://www.readbyqxmd.com/read/29870396/deconstructing-chronicity-of-musculoskeletal-pain-intensity-duration-relations-minimal-dimensions-and-clusters-of-chronicity
#13
Marina M Finnern, Dieter Kleinböhl, Herta Flor, Justus Benrath, Rupert Hölzl
BACKGROUND AND AIMS: Evaluating the degree to which pain has become chronic beyond mere duration poses several problems. The IASP Pain Taxonomy Axis IV employs intensity and duration combined to nine ordered categories. The Chronic Pain Grade links intensity and disability, but only the latter contributes to higher grades. The Mainz Pain Staging System includes temporal and spatial aspects, medication and health care utilization. Their interrelations, scale properties and construct validity are not always known or debatable...
June 5, 2018: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29869475/-chronic-pelvic-pain-syndrome-and-crohn-s-disease-a-dangerous-association
#14
G Briganti, J-P Falla, T Roumeguère
We present the case of a 54 year old male complaining of abdominal pain localised in the right flank and irradiating in other abdominal regions. The pain was previously associated with kidney stones, but persisted months after their total evacuation. Suffering from Crohn's disease, low dose corticosteroids likely caused a particularly invalidating chronic prostatitis, which antibiotic treatment aggravated the symptoms of Crohn's disease, therefore complicating the therapeutic care by causing a vicious circle...
May 30, 2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29864152/epidemiology-of-complex-regional-pain-syndrome-in-korea-an-electronic-population-health-data-study
#15
Hyungtae Kim, Cheol-Hyeong Lee, Sung-Hun Kim, Yeon-Dong Kim
Chronic regional pain syndrome (CRPS) is an inflammatory and neuropathic pain disorder characterized by the involvement of the autonomic nervous system with sensory, autonomic, motor, skin, and bone changes. At present, universally accepted consensus criteria for CRPS are not yet established, despite the diagnostic criteria proposed by the International Association for the Study of Pain (IASP). Various hypotheses for the pathophysiology of CRPS have been proposed; as a result, current therapeutic modalities are varied...
2018: PloS One
https://www.readbyqxmd.com/read/29846797/structural-brain-changes-versus-self-report-machine-learning-classification-of-chronic-fatigue-syndrome-patients
#16
Landrew S Sevel, Jeff Boissoneault, Janelle E Letzen, Michael E Robinson, Roland Staud
Chronic fatigue syndrome (CFS) is a disorder associated with fatigue, pain, and structural/functional abnormalities seen during magnetic resonance brain imaging (MRI). Therefore, we evaluated the performance of structural MRI (sMRI) abnormalities in the classification of CFS patients versus healthy controls and compared it to machine learning (ML) classification based upon self-report (SR). Participants included 18 CFS patients and 15 healthy controls (HC). All subjects underwent T1-weighted sMRI and provided visual analogue-scale ratings of fatigue, pain intensity, anxiety, depression, anger, and sleep quality...
May 30, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29797500/repetitive-transcranial-magnetic-stimulation-for-chronic-neuropathic-pain-in-patients-with-bladder-pain-syndrome-interstitial-cystitis
#17
Mauro Cervigni, Emanuela Onesti, Marco Ceccanti, Maria C Gori, Giorgio Tartaglia, Giuseppe Campagna, Giovanni Panico, Lorenzo Vacca, Chiara Cambieri, Laura Libonati, Maurizio Inghilleri
AIMS: To evaluate the efficacy, safety, and tolerability of repetitive Transcranial Magnetic Stimulation (rTMS) associated with standard drug therapies for neuropathic pain that does not respond to pharmacological treatment alone in patients with Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC). Secondary goals were to assess the effects of rTMS on Lower Urinary Tract Symptoms (LUTS) and Quality of Life (QOL). METHODS: Fifteen patients with BPS/IC were enrolled in this randomized, double-blind, sham stimulation-controlled, crossover study...
May 24, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29797376/linaclotide-inhibits-colonic-and-urinary-bladder-hypersensitivity-in-adult-female-rats-following-unpredictable-neonatal-stress
#18
C Ligon, E Mohammadi, P Ge, G Hannig, C Higgins, B Greenwood-Van Meerveld
BACKGROUND: Irritable bowel syndrome (IBS) and bladder pain syndrome (BPS) are female-predominant, chronic functional pain disorders that are associated with early life stress (ELS) and therapeutic options for such patients remain limited. Linaclotide, a guanylate cyclase-C (GC-C) agonist, relieves abdominal pain and bowel symptoms in adult patients suffering from IBS with constipation. Here, we test the hypothesis that linaclotide will reverse colon and bladder hyperalgesia in a female-specific rodent model of adverse early life experience...
May 24, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29787471/hemi-sensory-disturbances-in-patients-with-complex-regional-pain-syndrome
#19
Peter D Drummond, Philip M Finch, Frank Birklein, Michael Stanton-Hicks, Lone F Knudsen
Sensory disturbances often spread beyond the site of injury in complex regional pain syndrome (CRPS) but whether this applies equally to CRPS I and II, or changes across the course of the disease, is unknown. Establishing this is important, because different symptom profiles in CRPS I and II, or in acute versus chronic CRPS, might infer different pathophysiology and treatment approaches. To explore these questions, sensory disturbances were assessed in the limbs and forehead of 71 patients with CRPS I and 33 patients with CRPS II...
May 21, 2018: Pain
https://www.readbyqxmd.com/read/29773953/mir-34a-mediated-regulation-of-xist-in-female-cells-under-inflammation
#20
Botros B Shenoda, Yuzhen Tian, Guillermo M Alexander, Enrique Aradillas-Lopez, Robert J Schwartzman, Seena K Ajit
Background: Evidence is overwhelming for sex differences in pain, with women representing the majority of the chronic pain patient population. There is a need to explore novel avenues to elucidate this sex bias in the development of chronic inflammatory pain conditions. Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder, and the incidence of CRPS is greater in women than in men by ~4:1. Since neurogenic inflammation is a key feature of CRPS, dysregulation of inflammatory responses can be a factor in predisposing women to chronic pain...
2018: Journal of Pain Research
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