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Rikinkumar S Patel, Priya Patel, Kaushal Shah, Mandeep Kaur, Zeeshan Mansuri, Ramkrishna Makani
Objective To determine the impact of cannabis use disorder (CUD) on the inpatient outcomes of attention deficit hyperactivity disorder (ADHD) in adolescents Background Previous studies have evaluated the impact of CUD on the health-related quality of life in ADHD patients. Methods We used the nationwide inpatient sample (NIS) from the Healthcare Cost and Utilization Project (HCUP) from years 2010--2014. We identified ADHD and cannabis use (CU) as the primary and the other diagnosis, respectively, using validated International Classification of Diseases, 9th Revision, and Clinical Modification (ICD-9--CM) codes...
January 7, 2018: Curēus
Patricia P Chang, Lisa M Wruck, Eyal Shahar, Joseph S Rossi, Laura R Loehr, Stuart D Russell, Sunil K Agarwal, Suma H Konety, Carlos J Rodriguez, Wayne D Rosamond
Background -Community trends of acute decompensated heart failure (ADHF) in diverse populations may differ by race and sex. Methods -The Atherosclerosis Risk in Communities (ARIC) Study sampled heart failure related hospitalizations (age ≥55 years) in four US communities from 2005-2014 using ICD-9-CM codes. ADHF hospitalizations were validated by standardized physician review and computer algorithm, yielding 40,173 events after accounting for sampling design (unweighted n=8746). Results -Of the ADHF hospitalizations, 50% had reduced ejection fraction (HFrEF), 39% had preserved EF (HFpEF)...
March 8, 2018: Circulation
Adeleke D Adewumi, Samantha A Hollingworth, Joemer C Maravilla, Jason P Connor, Rosa Alati
BACKGROUND: The rate of an unintentional drug overdose involving prescription opioids continues to rise. An understanding of the threshold dose and dose(s) associated with unintentional prescription opioid overdose will help to mitigate this epidemic. OBJECTIVE: The objective of this systematic review is to systematically synthesise and meta-analyse studies on doses of prescription opioids and ascertain the doses of opioids that are associated with increased risk of severe opioid poisoning or mortality...
March 1, 2018: CNS Drugs
Tamara D Simon, Wren Haaland, Katherine Hawley, Karen Lambka, Rita Mangione-Smith
OBJECTIVES: To modify the Pediatric Medical Complexity Algorithm (PMCA) to include both International Classification of Diseases, Ninth and Tenth Revision, Clinical Modification (ICD-9/10-CM) codes for classifying children with chronic disease (CD) by level of medical complexity; and to assess the sensitivity and specificity of the new PMCA Version 3.0 for correctly identifying level of medical complexity. METHODS: To create Version 3.0, PMCA Version 2.0 was modified to include ICD-10-CM codes...
February 26, 2018: Academic Pediatrics
Deborah Kim, Kyung Min Lee, Marc R Freiman, W Ryan Powell, Elizabeth S Klings, Seppo Rinne, Donald Miller, Adam J Rose, Renda Soylemez Wiener
RATIONALE: Care of patients with pulmonary hypertension (PH) is complex. While pulmonary vasodilators are effective for Group 1 PH, clinical guidelines and the Choosing Wisely Campaign recommend against routine use for Groups 2 and 3 PH (the most common types of PH) due to a lack of benefit, potential for harm, and high cost ($10,000-$13,000 per patient per year treated). Little is known about how these medications are used in practice. OBJECTIVE(S): To determine national patterns of phosphodiesterase-5-inhibitor (PDE5i) prescribing for PH in the Veterans Health Administration (VA)...
February 27, 2018: Annals of the American Thoracic Society
Naveed Zafar Janjua, Nazrul Islam, Margot Kuo, Amanda Yu, Stanley Wong, Zahid A Butt, Mark Gilbert, Jane Buxton, Nuria Chapinal, Hasina Samji, Mei Chong, Maria Alvarez, Jason Wong, Mark W Tyndall, Mel Krajden
BACKGROUND: Large linked healthcare administrative datasets could be used to monitor programs providing prevention and treatment services to people who inject drugs (PWID). However, diagnostic codes in administrative datasets do not differentiate non-injection from injection drug use (IDU). We validated algorithms based on diagnostic codes and prescription records representing IDU in administrative datasets against interview-based IDU data. METHODS: The British Columbia Hepatitis Testers Cohort (BC-HTC) includes ∼1...
February 23, 2018: International Journal on Drug Policy
Yasmin D Hailer, Nils P Hailer
BACKGROUND: Osteochondrosis includes numerous diseases that occur during rapid growth, characterized by disturbances of endochondral ossification. One example, Legg-Calvé-Perthes disease, is characterized by disruption of the blood supply to the femoral head epiphysis, and a systemic etiology often has been suggested. If this were the case, secondary osteochondroses at locations other than the hip might be expected to be more common among patients with Legg-Calvé-Perthes disease, but to our knowledge, this has not been evaluated in a nationwide sample...
February 23, 2018: Clinical Orthopaedics and related Research
Ravikanth Papani, Gulshan Sharma, Amitesh Agarwal, Sean J Callahan, Winston J Chan, Yong-Fang Kuo, Yun M Shim, Andrew D Mihalek, Alexander G Duarte
Administrative claims studies do not adequately distinguish pulmonary arterial hypertension (PAH) from other forms of pulmonary hypertension (PH). Our aim is to develop and validate a set of algorithms using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes and electronic medical records (EMR), to identify patients with PAH. From January 2012 to August 2015, the EMRs of patients with ICD-9-CM codes for PH with an outpatient visit at the University of Texas Medical Branch were reviewed...
April 2018: Pulmonary Circulation
Huabin Luo, Sundar Shrestha, Xinzhi Zhang, Jinan Saaddine, Xiaoming Zeng, Timothy Reeder
PURPOSE: To describe the trends in eye injuries and associated medical costs among children in the United States. METHODS: Data were from the 2002-2014 Medical Expenditure Panel Survey (MEPS). Eye injuries in children aged <18 years were identified by the International Classification of Diseases-9 (ICD-9) codes. The trends of cumulative incidence of eye injury, total costs, and average costs were estimated from 2002-2014 MEPS data. All costs were adjusted to 2014 US dollars...
February 23, 2018: Ophthalmic Epidemiology
Eric M Ammann, Adam Cuker, Ryan M Carnahan, Usha S Perepu, Scott K Winiecki, Marin L Schweizer, Charles E Leonard, Candace C Fuller, Crystal Garcia, Cole Haskins, Elizabeth A Chrischilles
The Sentinel Distributed Database (SDD) is a database of patient administrative healthcare records, derived from insurance claims and electronic health records, sponsored by the US Food and Drug Administration for evaluation of medical product outcomes. There is limited information on the validity of diagnosis codes for acute venous thromboembolism (VTE) in the SDD and administrative healthcare data more generally.In this chart validation study, we report on the positive predictive value (PPV) of inpatient administrative diagnosis codes for acute VTE-pulmonary embolism (PE) or lower-extremity or site-unspecified deep vein thrombosis (DVT)-within the SDD...
February 2018: Medicine (Baltimore)
Paulus Torkki, Riikka-Leena Leskelä, Miika Linna, Suvi Mäklin, Jukka-Pekka Mecklin, Petri Bono, Vesa Kataja, Sakari Karjalainen
BACKGROUND: The cost of cancer and outcomes of cancer care have been discussed a lot since cancer represents 3-6% of total healthcare costs and cost estimations have indicated growing costs. There are studies considering the cost of all cancers, but studies focusing on the cost of disease and outcomes in most common cancer sites are limited. The objective of this study was to analyze the development of the costs and outcomes in Finland between 2009 and 2014 per cancer site. METHODS: The National cost, episode and outcomes data were obtained from the National register databases based on International Statistical Classification of Diseases (ICD)-10 diagnosis codes...
February 16, 2018: Acta Oncologica
Eric M Ammann, Marin L Schweizer, Jennifer G Robinson, Jayasheel O Eschol, Rami Kafa, Saket Girotra, Scott K Winiecki, Candace C Fuller, Ryan M Carnahan, Charles E Leonard, Cole Haskins, Crystal Garcia, Elizabeth A Chrischilles
BACKGROUND: The Sentinel Distributed Database (SDD) is a large database of patient-level administrative health care records, primarily derived from insurance claims and electronic health records, and is sponsored by the US Food and Drug Administration for medical product safety evaluations. Acute myocardial infarction (AMI) is a common study endpoint for drug safety studies that rely on health records from the SDD and other administrative databases. PURPOSE: In this chart validation study, we report on the positive predictive value (PPV) of inpatient International Classification of Diseases, Ninth Revision, Clinical Modification AMI administrative diagnosis codes (410...
February 15, 2018: Pharmacoepidemiology and Drug Safety
Yizhao Ni, Kathleen Alwell, Charles J Moomaw, Daniel Woo, Opeolu Adeoye, Matthew L Flaherty, Simona Ferioli, Jason Mackey, Felipe De Los Rios La Rosa, Sharyl Martini, Pooja Khatri, Dawn Kleindorfer, Brett M Kissela
OBJECTIVE: 1) To develop a machine learning approach for detecting stroke cases and subtypes from hospitalization data, 2) to assess algorithm performance and predictors on real-world data collected by a large-scale epidemiology study in the US; and 3) to identify directions for future development of high-precision stroke phenotypic signatures. MATERIALS AND METHODS: We utilized 8,131 hospitalization events (ICD-9 codes 430-438) collected from the Greater Cincinnati/Northern Kentucky Stroke Study in 2005 and 2010...
2018: PloS One
Naveed Afzal, Vishnu Priya Mallipeddi, Sunghwan Sohn, Hongfang Liu, Rajeev Chaudhry, Christopher G Scott, Iftikhar J Kullo, Adelaide M Arruda-Olson
BACKGROUND: Critical limb ischemia (CLI) is a complication of advanced peripheral artery disease (PAD) with diagnosis based on the presence of clinical signs and symptoms. However, automated identification of cases from electronic health records (EHRs) is challenging due to absence of a single definitive International Classification of Diseases (ICD-9 or ICD-10) code for CLI. METHODS AND RESULTS: In this study, we extend a previously validated natural language processing (NLP) algorithm for PAD identification to develop and validate a subphenotyping NLP algorithm (CLI-NLP) for identification of CLI cases from clinical notes...
March 2018: International Journal of Medical Informatics
Aline Wolfensberger, Angela H Meier, Stefan P Kuster, Tarun Mehra, Marie-Theres Meier, Hugo Sax
As surveillance of hospital acquired pneumonia (HAP) is very resource intensive, alternatives for HAP-surveillance are urgently needed. We compared HAP-rates according to routine discharge diagnostic codes of the International Classification of Diseases, tenth Revision (ICD-10; ICD-HAP) and the validated surveillance definitions of the Hospitals in Europe Link for Infection Control through Surveillance (HELICS/IPSE; HELICS-HAP) by manual retrospective reevaluation of patient records. We found a positive predictive value and sensitivity of ICD-HAP for HELICS-HAP of 0...
February 1, 2018: Journal of Hospital Infection
Soo Beom Choi, Wanhyung Lee, Jin-Ha Yoon, Jong-Uk Won, Deok Won Kim
BACKGROUND: Death by suicide is a preventable public health concern worldwide. The aim of this study is to investigate the probability of suicide death using baseline characteristics and simple medical facility visit history data using Cox regression, support vector machines (SVMs), and deep neural networks (DNNs). METHOD: This study included 819,951 subjects in the National Health Insurance Service (NHIS)-Cohort Sample Database from 2004 to 2013. The dataset was divided randomly into two independent training and validation groups...
January 31, 2018: Journal of Affective Disorders
An Jen Chiang, Chung Chang, Chi Hsiang Huang, Wei Chun Huang, Yuen Yee Kan, Jiabin Chen
OBJECTIVE: The objective was to identify risk factors that were associated with the progression from endometriosis to ovarian cancer based on medical insurance data. METHODS: The study was performed on a dataset obtained from the National Health Insurance Research Database, which covered all the inpatient claim data from 2000 to 2013 in Taiwan. The International Classification of Diseases (ICD) code 617 was used to screen the dataset for the patients who were admitted to hospital due to endometriosis...
February 1, 2018: Journal of Gynecologic Oncology
Eric M Ammann, Enrique C Leira, Scott K Winiecki, Nandakumar Nagaraja, Sudeepta Dandapat, Ryan M Carnahan, Marin L Schweizer, James C Torner, Candace C Fuller, Charles E Leonard, Crystal Garcia, Madelyn Pimentel, Elizabeth A Chrischilles
The Sentinel Distributed Database (SDD) is a large database of patient-level medical and prescription records, primarily derived from insurance claims and electronic health records, and is sponsored by the U.S. Food and Drug Administration for drug safety assessments. In this chart validation study, we report on the positive predictive value (PPV) of inpatient ICD-9-CM acute ischemic stroke (AIS) administrative diagnosis codes (433.x1, 434.xx, and 436) in the SDD.As part of an assessment of the risk of thromboembolic adverse events following treatment with intravenous immune globulin (IGIV), charts were obtained for 131 potential post-IGIV AIS cases...
December 2017: Medicine (Baltimore)
Nishant Sahni, Gyorgy Simon, Rashi Arora
BACKGROUND: Predicting death in a cohort of clinically diverse, multicondition hospitalized patients is difficult. Prognostic models that use electronic medical record (EMR) data to determine 1-year death risk can improve end-of-life planning and risk adjustment for research. OBJECTIVE: Determine if the final set of demographic, vital sign, and laboratory data from a hospitalization can be used to accurately quantify 1-year mortality risk. DESIGN: A retrospective study using electronic medical record data linked with the state death registry...
January 30, 2018: Journal of General Internal Medicine
Alexander J Butwick, Eileen M Walsh, Michael Kuzniewicz, Sherian X Li, Gabriel J Escobar
BACKGROUND: Determining the accuracy of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9) codes for postpartum hemorrhage (PPH) is vital for reaching valid conclusions about the epidemiology of PPH. Our primary objectives were to assess the performance characteristics of ICD-9 PPH codes against a reference standard using estimated blood loss (EBL) among a cohort undergoing Cesarean delivery. STUDY DESIGN AND METHODS: We analyzed maternal discharge and EBL data from women who underwent Cesarean delivery at Kaiser Permanente Northern California facilities between 2010 and 2013...
January 26, 2018: Transfusion
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