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diclofenac gout

Celso Ricardo Jesus, Eduardo Ferreira Molina, Sandra Helena Pulcinelli, Celso V Santilli
In this work, we report the effects of incorporation of variable amounts (1-20 wt%) of sodium montmorillonite (MMT) into a siloxane-poly(ethylene oxide) hybrid hydrogel prepared by the sol-gel route. The aim was to control the nanostructural features of the nanocomposite, improve the release profile of the drug sodium diclofenac (SDCF), and optimize the swelling behavior of the hydrophilic matrix. The nanoscopic characteristics of the siloxane-crosslinked poly(ethylene oxide) network, the semi-crystallinity of the hybrid, and the intercalated or exfoliated structure of the clay were investigated by X-ray diffraction (XRD), small-angle X-ray scattering (SAXS), and differential scattering calorimetry (DSC)...
May 11, 2018: ACS Applied Materials & Interfaces
Elaine Cruz Rosas, Luana Barbosa Correa, Tatiana de Almeida Pádua, Thadeu Estevam Moreira Maramaldo Costa, José Luiz Mazzei, Alan Patrick Heringer, Carlos Alberto Bizarro, Maria Auxiliadora Coelho Kaplan, Maria Raquel Figueiredo, Maria G Henriques
ETHNOPHARMACOLOGICAL RELEVANCE: Schinus terebinthifolius is a species of plant from the Anacardiaceae family, which can be found in different regions of Brazil. Schinus is popularly known as aroeirinha, aroeira-vermelha, or Brazilian pepper. In folk medicine, S. terebinthifolius is used for several disorders, including inflammatory conditions, skin wounds, mucosal membrane ulcers, respiratory problems, gout, tumors, diarrhea and arthritis. According to chemical analyses, gallic acid, methyl gallate and pentagalloylglucose are the main components of hydroalcoholic extracts from S...
December 4, 2015: Journal of Ethnopharmacology
Shaobo Zhang, Yibao Zhang, Peng Liu, Wei Zhang, Jing-Lin Ma, Jing Wang
The aim is to study the efficacy and safety of etoricoxib in the treatment of acute gout, as compared with non-steroidal anti-inflammatory drugs (NSAIDs). We conducted a computerized search of electronic databases: PubMed, EMBASE, Web of Science, China Biology Medicine disc, and Cochrane Library. The search terms were as follows: gout arthritis, tophus, etoricoxib, indometacin naproxen, diclofenac, and NSAIDs. Articles were searched from 1983 until August 2014. A manual search of peer-reviewed English documents was performed by cross-checking the bibliographies of selected studies...
January 2016: Clinical Rheumatology
Irene Zorrilla, Rosa Martinez, Mark A Taggart, Ngaio Richards
Exposure to residues of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac present in livestock carcasses has caused extensive declines in 3 Gyps vulture species across Asia. The carcass of a wild Eurasian Griffon Vulture (Gyps fulvus) was found in 2012 on an Andalucian (Spain) game hunting reserve and examined forensically. The bird had severe visceral gout, a finding consistent with Gyps vultures from Asia that have been poisoned by diclofenac. Liver and kidney samples from this Eurasian Griffon Vulture contained elevated flunixin (an NSAID) levels (median = 2...
April 2015: Conservation Biology: the Journal of the Society for Conservation Biology
Mi Zhou, Yi-Fei Wang, Ru Zhou, Ming Zhang, Bin Li
OBJECTIVE: To evaluate the clinical efficacy of a series of Tongfeng Granule (TG) in treating gouty arthritis patients in different stages. METHODS: Ninety primary gout patients were randomly assigned to two groups, the TCM treatment group (60 cases) and the Western medicine control group (30 cases). Huzhang Tongfeng Granule in combination of external application of Jinhuang Ointment were given to those in the TCM treatment group in the acute phase, and Yinlian Tongfeng Granule in the remission phase...
December 2013: Chinese Journal of Integrated Traditional and Western Medicine
Y-K Zhang, H Yang, J-Y Zhang, L-J Song, Y-C Fan
INTRODUCTION: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of acute gouty arthritis but have the risk of gastrointestinal bleeding and cardiovascular toxicity. Glucocorticoid was as effective as oral NSAIDs in the initial treatment of gout arthritis of patients intolerant of NSAIDs. However, whether glucocorticoid has the same or preferable effect as oral NSAIDs on patients with acute gouty arthritis irrespective of gastrointestinal and cardiovascular risks factor remains unknown...
May 2014: International Journal of Clinical Practice
Ernest Suresh
Acute monoarthritis is a common medical emergency with wide differential diagnosis. Common underlying causes include trauma, septic arthritis, crystal induced arthritis (gout and pseudogout), and reactive arthritis. Of these, septic arthritis is the diagnosis not to miss because of its association with significant morbidity and mortality. Precise diagnosis of the underlying cause of monoarthritis relies on a good history, physical examination findings, and results of focussed investigations. In this article, a practical approach to diagnosis and initial management of patients presenting with acute monoarthritis is described with the aid of a case vignette...
2013: Acute Medicine
Xia-Yi Xiao, Yi-Fei Wang, Rong Xu
OBJECTIVE: To investigate the quality of life in patients with gout and their influencing factors, and to observe the effects of the intervention program of stage-based treatment of integrative medicine (IM). METHODS: Totally 120 patients with acute attack of gout within 72 h were randomly assigned to the treatment group and the control group, 60 in each group. Patients in the treatment group were treated with Huzhang Tongfeng Granule (HTG), diclofenac sodium extended-release capsule and Jinhuang Ointment (JO) in the acute stage, and Yinlian Tongfeng Granule (YTG) and Benzbromarone Tablet (BT) in the intermission stage...
May 2012: Chinese Journal of Integrated Traditional and Western Medicine
V Naidoo, N Duncan, L Bekker, G Swan
Diclofenac has recently been identified as a cause of the widespread vulture decline on the Indian subcontinent. Although the clinical signs and pathology have been described, the pathophysiology of toxicity remains unexplained. In the following study we attempt to validate the domestic fowl as a model, to allow for the further characterisation of diclofenac's mechanism of toxicity. In a lethal dose study, diclofenac was shown to have an approximate intramuscular LD(50) of 9.8mg/kg in 18-week old layers. Signs of toxicity in the affected birds were severe depression that persisted from 24h post-dosing to death with corresponding increased plasma uric acid concentrations...
November 2007: Environmental Toxicology and Pharmacology
P Sarzi-Puttini, F Atzeni, L Lanata, M Bagnasco, M Colombo, F Fischer, M D'Imporzano
Ketoprofen is a drug belonging to the family of non-steroidal anti-inflammatory drugs (NSAIDs). The present review examines the main available clinical evidence of ketoprofen in the treatment of acute and chronic pain, of both rheumatic and traumatic origin, as well as postoperative pain. Ketoprofen has shown to be an excellent choice of drug for the treatment of chronic pain in patients with osteoarthritis, rheumatoid arthritis or gout, demonstrating a high level of efficacy with good tolerability also in elderly patients...
July 2010: Reumatismo
Ming Zhang, Jin-feng Wang, Yi-fei Wang
OBJECTIVE: To clarify the correlation between primary gout and insulin-resistance (IR), and to observe the effect of serial gout granules (SGGs) on IR in patients with primary gout. METHODS: Pearson's correlation analysis and multiple stepwise correlation analysis were conducted between 60 patients and 60 healthy volunteers in terms of blood pressure (BP), blood levels of uric acid (sUA), fasting plasma glucose (FPG), fasting insulin (FINS), fasting leptin (FL), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and C-peptide (CP), body mass index (BMI), waist-to-hip ratio (WHR), insulin resistance index (IRI) and insulin sensitivity index (ISI)...
December 2009: Chinese Journal of Integrated Traditional and Western Medicine
Teenu Jain, K M Koley, V P Vadlamudi, R C Ghosh, S Roy, Sandhya Tiwari, Upasana Sahu
OBJECTIVE: HASH(0x3eb2508) OBJECTIVE: To evaluate diclofenac-induced biochemical and histopathological changes in White Leghorn birds. MATERIALS AND METHODS: Six-week-old birds were equally divided into three groups of six birds each. Group I served as control and received vehicle orally. The birds of Group II and III were orally administered with a single low (2 mg/kg) and high dose (20 mg/kg) of diclofenac sodium, respectively, and were observed for 7 days...
October 2009: Indian Journal of Pharmacology
Edward Roddy, Christian D Mallen, Samantha L Hider, Kelvin P Jordan
OBJECTIVE: To describe prescribing patterns and cardiovascular risk factor screening in patients, following consultation for acute gout in primary care. METHODS: This study was undertaken in two inter-linked regional primary care databases: Consultations in Primary Care Archive (CiPCA) and Prescriptions in Primary Care Archive (PiPCA). During 2001-04, consultations in CiPCA were identified at 10 participating practices from gout-related Read morbidity codes. Lipid, blood pressure, glucose and renal function monitoring were identified from Read codes and consultation free text over the next month...
January 2010: Rheumatology
Irtaza Hussain, M Zargham Khan, Ahrar Khan, Ijaz Javed, M Kashif Saleemi
The objective of the present study was to investigate the toxico-pathological effects of diclofenac in different avian species including broiler chicks (Gallus gallus, 15 days old), pigeons (Columba livia, 3 months old), Japanese quail (Coturnix japonica, 4 weeks old) and mynah (Acridotheres tristis, independent young). For each species, five groups each containing 10 birds were maintained and administered diclofenac sodium orally at dose rates of 0, 0.25, 2.5, 10 and 20 mg/kg body weight, respectively, for seven consecutive days...
June 2008: Avian Pathology: Journal of the W.V.P.A
Yi-fei Wang, Bo-hua Li, Ming Zhang, Wen-bin Xu, Rong Zhou, Min Zhou
OBJECTIVE: To evaluate the clinical therapeutic effect of the combination therapy of traditional Chinese and Western medicines in treating gouty arthritis based on the stage of disease, and to explore a safe, effective and reasonable therapeutic regimen for prevention and treatment of gouty arthritis. METHODS: One hundred and sixty-six cases of gouty arthritis were divided into three groups randomly, 58 cases in traditional Chinese drug (TCD)-treated group, 56 cases in Western medicine (WM)-treated group and 52 cases in TCD plus WM-treated group...
June 2008: Zhong Xi Yi Jie He Xue Bao, Journal of Chinese Integrative Medicine
Barnett A Rattner, Maria A Whitehead, Grace Gasper, Carol U Meteyer, William A Link, Mark A Taggart, Andrew A Meharg, Oliver H Pattee, Deborah J Pain
The nonsteroidal anti-inflammatory drug diclofenac is extremely toxic to Old World Gyps vultures (median lethal dose -0.1-0.2 mg/kg), evoking visceral gout, renal necrosis, and mortality within a few days of exposure. Unintentional secondary poisoning of vultures that fed upon carcasses of diclofenac-treated livestock decimated populations in the Indian subcontinent. Because of the widespread use of diclofenac and other cyclooxygenase-2 inhibiting drugs, a toxicological study was undertaken in turkey vultures (Cathartes aura) as an initial step in examining sensitivity of New World scavenging birds...
November 2008: Environmental Toxicology and Chemistry
Emil Loldrup Fosbøl, Gunnar H Gislason, Søren Jacobsen, Steen Z Abildstrom, Morten Lock Hansen, Tina Ken Schramm, Fredrik Folke, Rikke Sørensen, Jeppe N Rasmussen, Lars Køber, Mette Madsen, Christian Torp-Pedersen
PURPOSE: To describe the nationwide pattern of use of non-steroidal anti-inflammatory drugs (NSAIDs) in the Danish population. METHODS: All Danish citizens aged 10 or above 1 January 1997 were included in the study. The national prescription registry was used to identify all claimed prescriptions for NSAIDs by the cohort until 2005. By individual-level-linkage of nationwide registries, information was acquired concerning hospitalizations, comorbidity, concomitant pharmacotherapy and socioeconomic factors...
August 2008: Pharmacoepidemiology and Drug Safety
(no author information available yet)
(1) Paracetamol is the first-choice analgesic for joint pain. Nonsteroidal antiinflammatory drugs (NSAIDs), especially ibuprofen, are second-line options. Cox-2 inhibitors are no more effective than traditional NSAIDs and have no tangible advantages in terms of gastrointestinal tolerability. In contrast, they expose patients to an increased risk of cardiovascular adverse effects. (2) Etoricoxib is marketed in some European countries to relieve symptoms of osteoarthritis, rheumatoid arthritis, and gout attacks...
December 2007: Prescrire International
F M Kudaeva, M S Eliseev, V G Barskova, V A Nasonova
AIM: To compare the time to presentation of the analgetic and anti-inflammatory effects of granulated and tablet nimesulide and sodium diclofenac since the start of therapy for gouty arthritis (GA). MATERIAL AND METHODS: Ninety males with gout were randomized into 3 equal groups. The patients were included in the study by the following criteria: a documented diagnosis of gout (Wallace S. criteria), age over 18 years, acute arthritis for less than 3 weeks, affection of 4 and more joints...
2007: Terapevticheskiĭ Arkhiv
R E Willburger, E Mysler, J Derbot, T Jung, H Thurston, A Kreiss, S Litschig, G Krammer, G A Tate
OBJECTIVES: To demonstrate non-inferiority of lumiracoxib 400 mg once daily (o.d.) compared with indomethacin 50 mg three times daily (t.i.d.) in the treatment of acute gout, and to compare the safety and tolerability of these treatments. METHODS: In this 1-week, multicentre, randomized, double-blind, double-dummy, active-controlled, parallel-group study, patients with a clinical diagnosis of gout, an acute attack of gout in four or more joints within the 48 h prior to evaluation, and at least moderate pain intensity in the target joint were randomized to treatment with lumiracoxib 400 mg o...
July 2007: Rheumatology
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