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Pediatric GER

Letizia Zenzeri, Paolo Quitadamo, Renato Tambucci, Dario Ummarino, Antonio Poziello, Erasmo Miele, Annamaria Staiano
OBJECTIVES: Respiratory symptoms are a possible atypical clinical picture of gastro-esophageal reflux disease (GERD). However, a significant number of patients with GERD-related respiratory symptoms do not report improvement despite aggressive acid-suppressive therapy. Some of these refractory cases may be due to the recently appreciated entity of non-acid or weakly acidic reflux. The aim of our study is to assess the pH-impedance features of GER inducing airway symptoms, compared with GER inducing typical gastro-intestinal (GI) symptoms...
October 13, 2016: Pediatric Pulmonology
Seyed Hamidreza Abtahi, Azadeh Kazerooni, Nezamodin Brejis, Zahra Abdeyazdan, Hossein Saneian
BACKGROUND: Otitis media (OM) is the most common cause of childhood hearing loss and reason to visit the pediatrician. Furthermore, gastroesophageal reflux (GER) has been associated with a variety of upper aerodigestive tract symptoms or diseases, such as sinusitis, laryngitis, and otits. The objective of the present study was to determine the frequency of GER in children, aged 3 months to 7 years, with OM. MATERIALS AND METHODS: This retrospective case-control study was conducted on 50 children with OM and 50 healthy children...
2016: Advanced Biomedical Research
Anna Górecka-Tuteja, Izabela Jastrzębska, Jacek Składzień, Krzysztof Fyderek
BACKGROUND/AIMS: To evaluate the characteristic properties of laryngopharyngeal reflux (LPR) and gastroesophageal reflux (GER) in children with otitis media with effusion (OME) using 24-hour multichannel intraluminal impedance combined with dual-probe (pharyngeal and esophageal) pH-metry. METHODS: Children aged 7-10 years of age with OME underwent 24-hour multichannel intraluminal impedance pH-metry. The upper pH sensor was situated 1 cm above the upper esophageal sphincter, and the lower pH sensor was placed 3-5 cm above the lower esophageal sphincter...
July 30, 2016: Journal of Neurogastroenterology and Motility
M A Dziekiewicz, K Karolewska-Bochenek, Ł Dembiński, A Gawronska, K Krenke, J Lange, M Banasiuk, E Kuchar, M Kulus, P Albrecht, A Banaszkiewicz
Gastroesophageal reflux disease is common in adult patients with interstitial lung disease. However, no data currently exist regarding the prevalence and characteristics of the disease in pediatric patients with interstitial lung disease. The aim of the present study was to prospectively assess the incidence of gastroesophageal reflux disease and characterize its features in children with interstitial lung disease. Gastroesophageal reflux disease was established based on 24 h pH-impedance monitoring (MII-pH)...
2016: Advances in Experimental Medicine and Biology
Gerly M de Boo, Maartje A Thijssen, Carole Lasham, Frans B Plötz
UNLABELLED: The short- and long-term psychological consequences of a single episode of alcohol intoxication in adolescents are unknown. Twenty-four adolescents (12 M, 12 F), mean age 18.3 ± 1.1 years, who had been admitted to the pediatric ward with alcohol intoxication (mean age at admission 15.6 ± 1.1) and thirty-two parents were interviewed on the intoxication episode and the subsequent consequences. This interview took place 2-3 years after the alcohol intoxication. At the same time, all participants completed questionnaires, assessing general and demographic information, detailed information about current alcohol use, present-day health-related quality of life, and psychological well-being...
July 2016: European Journal of Pediatrics
M Wirth, C Bonnemains, J Auger, E Raffo, B Leheup
Sandifer's syndrome is a dystonic movement disorder in infants with gastroesophageal reflux (GER). It is probably misdiagnosed as epileptic seizures. We report the case of a 5-month-old infant with no past medical history admitted to a pediatric unit for suspicion of infantile spasms. She presented with dystonic movements of the upper left limb with left blepharospasm and an occasional dystonic head posture. Physical examination, EEG, brain MRI, and blood analysis were normal. Since the baby experienced regurgitations, Sandifer's syndrome was suspected and confirmed by 24-h esophageal pH monitoring that documented pathological GER...
February 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Regina Balgowan, Leah C Greer, Jennifer P D'Auria
INTRODUCTION: The purpose of this study was to describe the type and quality of health information about infant gastroesophageal reflux (GER) that a parent may find on the World Wide Web. METHODS: The data collection tool included evaluation of Web site quality and infant GER-specific content on the 30 sites that met the inclusion criteria. RESULTS: The most commonly found content categories in order of frequency were management strategies, when to call a primary care provider, definition, and clinical features...
March 2016: Journal of Pediatric Health Care
Shannon N Acker, Becky B Trinh, David A Partrick, Camille L Stewart, Denis D Bensard
INTRODUCTION: Before gastrostomy tube (GT) placement, many pediatric surgeons request that children undergo a preoperative upper gastrointestinal contrast study (UGI) to evaluate for the presence of either gastroesophageal reflux (GER) or intestinal malrotation. We hypothesized that routine UGI is unnecessary before GT placement. MATERIALS AND METHODS: We performed a retrospective review of 500 consecutive children who had a GT placed in a single children's hospital from 2009 to 2012...
February 2016: European Journal of Pediatric Surgery
Marcin A Dziekiewicz, Aleksandra Banaszkiewicz, Agnieszka Urzykowska, Aleksandra Lisowska, Marta Rachel, Dorota Sands, Jaroslaw Walkowiak, Andrzej Radzikowski, Piotr Albrecht
Previously published studies have indicated that gastroesophageal reflux (GER) disease is common in pediatric patients with cystic fibrosis. The aim of the present study was to get insight into the incidence of GER and to characterize the nature of reflux episodes in children with cystic fibrosis. This was a multicenter, prospective study of children with cystic fibrosis older than 18 months. Forty four consecutive patients (22 boys, mean age 10.4 ± 3.6, range 3.0-17.8 years) were enrolled into the study...
2015: Advances in Experimental Medicine and Biology
Jigang Yang, Ion Codreanu, Sabah Servaes, Hongming Zhuang
OBJECTIVE: Both gastroesophageal reflux (GER) scintigraphy and radionuclide salivagram are commonly used in the detection of pulmonary aspiration in pediatric patients. This investigation is to compare the diagnostic value of these 2 imaging methods. METHODS: This retrospective study included 4186 pediatric patients (aged 1 week to 16 years; mean age, 28 months) who underwent a GER scintigraphy and/or radionuclide salivagram. Detection rate of pulmonary aspiration by the 2 imaging techniques was compared...
July 2015: Clinical Nuclear Medicine
Jin-Rong Liu, Xue-Feng Xu, Chun-Ju Zhou, Hai-Ming Yang, Shun-Ying Zhao
The most common causes of bronchiolitis obliterans organizing pneumonia (BOOP) are connective tissue diseases, organ transplantation, drug reaction, and infections. Although rare, BOOP due to gastroesophageal reflux (GER) has been reported in adults but not to date in pediatric patients. This study describes 2 pediatric patients who developed GER and BOOP. One patient had superior mesenteric artery syndrome and Helicobacter pylori infection, and the other had a gastroduodenal ulcer with reflux esophagitis. Respiratory symptoms occurred concurrently or after gastrointestinal symptoms...
June 2015: Pediatrics
Dillys van Vliet, Ariel Alonso, Ger Rijkers, Jan Heynens, Philippe Rosias, Jean Muris, Quirijn Jöbsis, Edward Dompeling
BACKGROUND: In asthma management guidelines the primary goal of treatment is asthma control. To date, asthma control, guided by symptoms and lung function, is not optimal in many children and adults. Direct monitoring of airway inflammation in exhaled breath may improve asthma control and reduce the number of exacerbations. AIM: 1) To study the use of fractional exhaled nitric oxide (FeNO) and inflammatory markers in exhaled breath condensate (EBC), in the prediction of asthma exacerbations in a pediatric population...
2015: PloS One
M J Smits, C M Loots, M P van Wijk, A J Bredenoord, M A Benninga, A J P M Smout
BACKGROUND: Despite existing criteria for scoring gastro-esophageal reflux (GER) in esophageal multichannel pH-impedance measurement (pH-I) tracings, inter- and intra-rater variability is large and agreement with automated analysis is poor. To identify parameters of difficult to analyze pH-I patterns and combine these into a statistical model that can identify GER episodes with an international consensus as gold standard. METHODS: Twenty-one experts from 10 countries were asked to mark GER presence for adult and pediatric pH-I patterns in an online pre-assessment...
May 2015: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Shlomi Cohen, Mirjam Bueno de Mesquita, Francis B Mimouni
Gastroesophageal reflux (GER) is commonly observed in children, particularly during the first year of life. Pharmacological therapy is mostly reserved for symptomatic infants diagnosed with GER disease (GERD), usually as defined in a recent consensus statement. The purpose of the present article was to review the reported adverse effects of pharmacological agents used in the treatment of paediatric GERD. We conducted this review using the electronic journal database Pubmed and Cochrane database systematic reviews using the latest 10-year period (1 January 2003 to 31 December 2012)...
August 2015: British Journal of Clinical Pharmacology
Sofie M A Walenbergh, Tom Houben, Tim Hendrikx, Mike L J Jeurissen, Patrick J van Gorp, Anita C E Vreugdenhil, Marlou P Adriaanse, Wim A Buurman, Marten H Hofker, Antonella Mosca, Patrick J Lindsey, Anna Alisi, Daniela Liccardo, Nadia Panera, Ger H Koek, Valerio Nobili, Ronit Shiri-Sverdlov
OBJECTIVES: Nonalcoholic steatohepatitis (NASH) is the most severe form of a hepatic condition known as nonalcoholic fatty liver disease (NAFLD). NASH is histologically characterized by hepatic fat accumulation, inflammation, and ballooning, and eventually coupled with fibrosis that, in turn, may progress to end-stage liver disease even in young individuals. Hence, there is a critical need for specific noninvasive markers to predict hepatic inflammation at an early age. We investigated whether plasma levels of cathepsin D (CatD), a lysosomal protease, correlated with the severity of liver inflammation in pediatric NAFLD...
March 2015: American Journal of Gastroenterology
Kohei Otake, Keiichi Uchida, Koichiro Mori, Shozo Ide, Yuhki Koike, Mitsuyuki Takamura, Mikihiro Inoue, Masato Kusunoki
BACKGROUND: Gastroesophageal reflux disease (GERD) in infants is among the most common reason for physician consultation worldwide. A traditional Japanese medicine, rikkunshito (RKT), is effective for GERD in adult and pediatric patients. The aim of this study was to evaluate the efficacy and safety of RKT in infants with GERD. METHODS: Fifty-four infants were referred to between July 2004 and December 2012 for evaluation and treatment of GERD. All infants had failure to thrive...
August 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
Chih-An Chou, Ting-I Lin, Yu-Shen Chen, Po-Yen Liu, Yung-Feng Huang, Ying-Yao Chen, Kai-Sheng Hsieh, Yao-Shen Chen, Luo-Ping Ger
BACKGROUND: Lower respiratory tract infections (LRTIs) play an important role in pediatric diseases; however, there are limited data about LRTIs in Southern Taiwan. This study aimed to investigate the clinical and epidemiological data of LRTIs in this area. METHODS: Children aged under 5 years who were hospitalized at a medical center in Southern Taiwan with acute LRTIs from July 2010 to October 2010 (summer) and from March 2011 to May 2011 (spring) were prospectively enrolled...
August 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Josephine Franken, Femke A Mauritz, Nutnicha Suksamanapun, Caroline C C Hulsker, David C van der Zee, Maud Y A van Herwaarden-Lindeboom
INTRODUCTION: A gastrostomy placement is frequently performed in pediatric patients who require long-term enteral tube feeding. However, data on efficacy, perioperative complications and postoperative gastroesophageal reflux (GER) after laparoscopic gastrostomy (LAG) placement is limited. The aim of this study is to evaluate long-term efficacy and adverse events after LAG in a large cohort and determine whether routine preoperative 24-h pH monitoring should be used to predict postoperative GER...
June 2015: Surgical Endoscopy
Kai-Chi Chang, Jia-Feng Wu, Wei-Chung Hsu, Bor-Ru Lin, Huey-Ling Chen, Yen-Hsuan Ni
BACKGROUND: Gastroesophageal flap valve (GEFV) endoscopic grading is reported to be associated with gastroesophageal reflux disease (GERD) in adults; however its role in pediatric groups remains unknown. This study aimed to investigate the significance of GEFV grading and the associations to multichannel intraluminal impedance and pH monitoring (MII-pH) in children with GERD. METHODS: A total of 48 children with GERD symptoms who received esophagogastroduodenoscopy and MII-pH monitoring were enrolled...
2014: PloS One
Hayat Mousa, Rodrigo Machado, Marina Orsi, Catherine S Chao, Tala Alhajj, Mark Alhajj, Courtney Port, Beth Skaggs, Frederick W Woodley
Although combined multichannel intraluminal impedance/esophageal pH monitoring (MII-pH) has replaced prolonged pH monitoring alone for assessing gastroesophageal reflux (GER) in the pediatric population, it does so in the absence of reference values for non-acid GER (NAGER). The purpose of this study was to identify a normal range of NAGER impedance values for infants and children. We evaluated EPM/MII tracings for patients referred for GER assessment to Nationwide Children's Hospital (Columbus, OH), Inova Children's Hospital, and Hospital Italiano (Buenos Aires, Argentina)...
August 2014: Current Gastroenterology Reports
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