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Pediatric GER

Helen Hsieh, Adam Frenette, Laurent Michaud, Usha Krishnan, Dorothée Bouron Dal-Soglio, Frederic Gottrand, Christophe Faure
OBJECTIVES: Patients with esophageal atresia/tracheo-esophageal fistula (EA-TEF) can develop Barrett's esophagus as a long-term consequence of their condition. Intestinal metaplasia (IM), a risk factor for developing adenocarcinoma of the esophagus, has not been well characterized in the pediatric population. METHODS: Retrospective review of EA-TEF patients followed at three academic pediatric centers between the years 1997 and 2014. RESULTS: Among 542 children and adolescents, 1...
February 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
Fei Jamie Dy, Dawn Freiberger, Enju Liu, Debra Boyer, Gary Visner, Rachel Rosen
BACKGROUND: Gastroesophageal reflux disease is thought to predispose to adverse lung allograft outcomes. However, little is known about the burden of gastroesophageal reflux (GER) and gastroparesis in pediatric patients. In this study we describe the burden of reflux and gastroparesis in children undergoing lung transplant, and evaluates their impact on allograft survival and rejection incidence. METHODS: This study is a retrospective analysis of pediatric lung transplant recipients who had combined pH and multichannel intraluminal impedance testing (pH-MII) and gastric-emptying scans (GES)...
January 6, 2017: Journal of Heart and Lung Transplantation
Bryan Stone, Gabrielle Hester, Daniel Jackson, Troy Richardson, Matt Hall, Ramkiran Gouripeddi, Ryan Butcher, Ron Keren, Rajendu Srivastava
BACKGROUND AND OBJECTIVES: Gastroesophageal reflux (GER), aspiration, and secondary complications lead to morbidity and mortality in children with neurologic impairment (NI), dysphagia, and gastrostomy feeding. Fundoplication and gastrojejunal (GJ) feeding can reduce risk. We compared GJ to fundoplication using first-year postprocedure reflux-related hospitalization (RRH) rates. METHODS: We identified children with NI, dysphagia requiring gastrostomy tube feeding and GER undergoing initial GJ placement or fundoplication from January 1, 2007 to December 31, 2012...
February 3, 2017: Hospital Pediatrics
Maurizio Pacilli, Mark Davenport
INTRODUCTION: Achalasia is a rare disorder in children who are commonly treated by laparoscopic Heller's myotomy (LHM). However, there are no large studies evaluating the results of LHM in the pediatric population, and the need of a concomitant fundoplication remains unclear. The aim of the study is to appraise the results of LHM based on a systematic literature review. MATERIALS AND METHODS: MEDLINE search of the English literature was performed for "achalasia," "children," "laparoscopy," "Heller," "myotomy," and "cardiomyotomy...
January 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Takahisa Tainaka, Hiroo Uchida, Akihide Tanano, Chiyoe Shirota, Akinari Hinoki, Naruhiko Murase, Kazuki Yokota, Kazuo Oshima, Ryo Shirotsuki, Kosuke Chiba, Hizuru Amano, Hiroshi Kawashima, Yujiro Tanaka
BACKGROUND: The treatment of long-gap esophageal atresia remains an issue for pediatric surgeons. Many techniques for treating long-gap esophageal atresia have been proposed, but the optimal method has not been established. The thoracoscopic esophageal elongation technique has recently been developed. We previously reported a case in which two-stage thoracoscopic repair was performed using internal esophageal traction without esophageal tearing, and we retrospectively reviewed the outcomes of this procedure in this study...
January 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Letizia Zenzeri, Paolo Quitadamo, Renato Tambucci, Dario Ummarino, Antonio Poziello, Erasmo Miele, Annamaria Staiano
OBJECTIVES: Respiratory symptoms are a possible atypical clinical picture of gastro-esophageal reflux disease (GERD). However, a significant number of patients with GERD-related respiratory symptoms do not report improvement despite aggressive acid-suppressive therapy. Some of these refractory cases may be due to the recently appreciated entity of non-acid or weakly acidic reflux. The aim of our study is to assess the pH-impedance features of GER inducing airway symptoms, compared with GER inducing typical gastro-intestinal (GI) symptoms...
May 2017: Pediatric Pulmonology
Seyed Hamidreza Abtahi, Azadeh Kazerooni, Nezamodin Brejis, Zahra Abdeyazdan, Hossein Saneian
BACKGROUND: Otitis media (OM) is the most common cause of childhood hearing loss and reason to visit the pediatrician. Furthermore, gastroesophageal reflux (GER) has been associated with a variety of upper aerodigestive tract symptoms or diseases, such as sinusitis, laryngitis, and otits. The objective of the present study was to determine the frequency of GER in children, aged 3 months to 7 years, with OM. MATERIALS AND METHODS: This retrospective case-control study was conducted on 50 children with OM and 50 healthy children...
2016: Advanced Biomedical Research
Anna Górecka-Tuteja, Izabela Jastrzębska, Jacek Składzień, Krzysztof Fyderek
BACKGROUND/AIMS: To evaluate the characteristic properties of laryngopharyngeal reflux (LPR) and gastroesophageal reflux (GER) in children with otitis media with effusion (OME) using 24-hour multichannel intraluminal impedance combined with dual-probe (pharyngeal and esophageal) pH-metry. METHODS: Children aged 7-10 years of age with OME underwent 24-hour multichannel intraluminal impedance pH-metry. The upper pH sensor was situated 1 cm above the upper esophageal sphincter, and the lower pH sensor was placed 3-5 cm above the lower esophageal sphincter...
July 30, 2016: Journal of Neurogastroenterology and Motility
M A Dziekiewicz, K Karolewska-Bochenek, Ł Dembiński, A Gawronska, K Krenke, J Lange, M Banasiuk, E Kuchar, M Kulus, P Albrecht, A Banaszkiewicz
Gastroesophageal reflux disease is common in adult patients with interstitial lung disease. However, no data currently exist regarding the prevalence and characteristics of the disease in pediatric patients with interstitial lung disease. The aim of the present study was to prospectively assess the incidence of gastroesophageal reflux disease and characterize its features in children with interstitial lung disease. Gastroesophageal reflux disease was established based on 24 h pH-impedance monitoring (MII-pH)...
2016: Advances in Experimental Medicine and Biology
Gerly M de Boo, Maartje A Thijssen, Carole Lasham, Frans B Plötz
UNLABELLED: The short- and long-term psychological consequences of a single episode of alcohol intoxication in adolescents are unknown. Twenty-four adolescents (12 M, 12 F), mean age 18.3 ± 1.1 years, who had been admitted to the pediatric ward with alcohol intoxication (mean age at admission 15.6 ± 1.1) and thirty-two parents were interviewed on the intoxication episode and the subsequent consequences. This interview took place 2-3 years after the alcohol intoxication. At the same time, all participants completed questionnaires, assessing general and demographic information, detailed information about current alcohol use, present-day health-related quality of life, and psychological well-being...
July 2016: European Journal of Pediatrics
M Wirth, C Bonnemains, J Auger, E Raffo, B Leheup
Sandifer's syndrome is a dystonic movement disorder in infants with gastroesophageal reflux (GER). It is probably misdiagnosed as epileptic seizures. We report the case of a 5-month-old infant with no past medical history admitted to a pediatric unit for suspicion of infantile spasms. She presented with dystonic movements of the upper left limb with left blepharospasm and an occasional dystonic head posture. Physical examination, EEG, brain MRI, and blood analysis were normal. Since the baby experienced regurgitations, Sandifer's syndrome was suspected and confirmed by 24-h esophageal pH monitoring that documented pathological GER...
February 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Regina Balgowan, Leah C Greer, Jennifer P D'Auria
INTRODUCTION: The purpose of this study was to describe the type and quality of health information about infant gastroesophageal reflux (GER) that a parent may find on the World Wide Web. METHODS: The data collection tool included evaluation of Web site quality and infant GER-specific content on the 30 sites that met the inclusion criteria. RESULTS: The most commonly found content categories in order of frequency were management strategies, when to call a primary care provider, definition, and clinical features...
March 2016: Journal of Pediatric Health Care
Shannon N Acker, Becky B Trinh, David A Partrick, Camille L Stewart, Denis D Bensard
INTRODUCTION: Before gastrostomy tube (GT) placement, many pediatric surgeons request that children undergo a preoperative upper gastrointestinal contrast study (UGI) to evaluate for the presence of either gastroesophageal reflux (GER) or intestinal malrotation. We hypothesized that routine UGI is unnecessary before GT placement. MATERIALS AND METHODS: We performed a retrospective review of 500 consecutive children who had a GT placed in a single children's hospital from 2009 to 2012...
February 2016: European Journal of Pediatric Surgery
Marcin A Dziekiewicz, Aleksandra Banaszkiewicz, Agnieszka Urzykowska, Aleksandra Lisowska, Marta Rachel, Dorota Sands, Jaroslaw Walkowiak, Andrzej Radzikowski, Piotr Albrecht
Previously published studies have indicated that gastroesophageal reflux (GER) disease is common in pediatric patients with cystic fibrosis. The aim of the present study was to get insight into the incidence of GER and to characterize the nature of reflux episodes in children with cystic fibrosis. This was a multicenter, prospective study of children with cystic fibrosis older than 18 months. Forty four consecutive patients (22 boys, mean age 10.4 ± 3.6, range 3.0-17.8 years) were enrolled into the study...
2015: Advances in Experimental Medicine and Biology
Jigang Yang, Ion Codreanu, Sabah Servaes, Hongming Zhuang
OBJECTIVE: Both gastroesophageal reflux (GER) scintigraphy and radionuclide salivagram are commonly used in the detection of pulmonary aspiration in pediatric patients. This investigation is to compare the diagnostic value of these 2 imaging methods. METHODS: This retrospective study included 4186 pediatric patients (aged 1 week to 16 years; mean age, 28 months) who underwent a GER scintigraphy and/or radionuclide salivagram. Detection rate of pulmonary aspiration by the 2 imaging techniques was compared...
July 2015: Clinical Nuclear Medicine
Jin-Rong Liu, Xue-Feng Xu, Chun-Ju Zhou, Hai-Ming Yang, Shun-Ying Zhao
The most common causes of bronchiolitis obliterans organizing pneumonia (BOOP) are connective tissue diseases, organ transplantation, drug reaction, and infections. Although rare, BOOP due to gastroesophageal reflux (GER) has been reported in adults but not to date in pediatric patients. This study describes 2 pediatric patients who developed GER and BOOP. One patient had superior mesenteric artery syndrome and Helicobacter pylori infection, and the other had a gastroduodenal ulcer with reflux esophagitis. Respiratory symptoms occurred concurrently or after gastrointestinal symptoms...
June 2015: Pediatrics
Dillys van Vliet, Ariel Alonso, Ger Rijkers, Jan Heynens, Philippe Rosias, Jean Muris, Quirijn Jöbsis, Edward Dompeling
BACKGROUND: In asthma management guidelines the primary goal of treatment is asthma control. To date, asthma control, guided by symptoms and lung function, is not optimal in many children and adults. Direct monitoring of airway inflammation in exhaled breath may improve asthma control and reduce the number of exacerbations. AIM: 1) To study the use of fractional exhaled nitric oxide (FeNO) and inflammatory markers in exhaled breath condensate (EBC), in the prediction of asthma exacerbations in a pediatric population...
2015: PloS One
M J Smits, C M Loots, M P van Wijk, A J Bredenoord, M A Benninga, A J P M Smout
BACKGROUND: Despite existing criteria for scoring gastro-esophageal reflux (GER) in esophageal multichannel pH-impedance measurement (pH-I) tracings, inter- and intra-rater variability is large and agreement with automated analysis is poor. To identify parameters of difficult to analyze pH-I patterns and combine these into a statistical model that can identify GER episodes with an international consensus as gold standard. METHODS: Twenty-one experts from 10 countries were asked to mark GER presence for adult and pediatric pH-I patterns in an online pre-assessment...
May 2015: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Shlomi Cohen, Mirjam Bueno de Mesquita, Francis B Mimouni
Gastroesophageal reflux (GER) is commonly observed in children, particularly during the first year of life. Pharmacological therapy is mostly reserved for symptomatic infants diagnosed with GER disease (GERD), usually as defined in a recent consensus statement. The purpose of the present article was to review the reported adverse effects of pharmacological agents used in the treatment of paediatric GERD. We conducted this review using the electronic journal database Pubmed and Cochrane database systematic reviews using the latest 10-year period (1 January 2003 to 31 December 2012)...
August 2015: British Journal of Clinical Pharmacology
Sofie M A Walenbergh, Tom Houben, Tim Hendrikx, Mike L J Jeurissen, Patrick J van Gorp, Anita C E Vreugdenhil, Marlou P Adriaanse, Wim A Buurman, Marten H Hofker, Antonella Mosca, Patrick J Lindsey, Anna Alisi, Daniela Liccardo, Nadia Panera, Ger H Koek, Valerio Nobili, Ronit Shiri-Sverdlov
OBJECTIVES: Nonalcoholic steatohepatitis (NASH) is the most severe form of a hepatic condition known as nonalcoholic fatty liver disease (NAFLD). NASH is histologically characterized by hepatic fat accumulation, inflammation, and ballooning, and eventually coupled with fibrosis that, in turn, may progress to end-stage liver disease even in young individuals. Hence, there is a critical need for specific noninvasive markers to predict hepatic inflammation at an early age. We investigated whether plasma levels of cathepsin D (CatD), a lysosomal protease, correlated with the severity of liver inflammation in pediatric NAFLD...
March 2015: American Journal of Gastroenterology
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