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https://www.readbyqxmd.com/read/29790690/validation-of-the-portuguese-version-of-addenbrooke-s-cognitive-examination-iii-in-mild-cognitive-impairment-and-dementia
#1
Bruno Peixoto, Milene Machado, Patricia Rocha, Carla Macedo, António Machado, Élia Baeta, Gerly Gonçalves, Paulo Pimentel, Emanuela Lopes, Luis Monteiro
BACKGROUND: Cognitive assessment is central to the diagnosis of cognitive impairment and dementia, and it should be performed in all patients in the early stages of the disease. Recently, the 3rd version of Addenbrooke's Cognitive Examination (ACE-III) has been developed in order to improve the previous versions. OBJECTIVES: The aim of this study was to determine the psychometric properties of the Portuguese version of ACE-III, namely: reliability and discriminative validity (sensitivity and specificity) in the identification of mild cognitive impairment (MCI) and dementia, in comparison to other neuropsychological screening tests, as well as to establish its concurrent and divergent validity...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29780462/fluorescent-dyes-and-probes-for-super-resolution-microscopy-of-microtubules-and-tracheoles-in-living-cells-and-tissues
#2
Gražvydas Lukinavičius, Gyuzel Y Mitronova, Sebastian Schnorrenberg, Alexey N Butkevich, Hannah Barthel, Vladimir N Belov, Stefan W Hell
We introduce fluorogenic tubulin probes based on the recently reported fluorescent dyes (510R, 580CP, GeR and SiR) and chemotherapy agents - taxanes (docetaxel, cabazitaxel and larotaxel). The cytotoxicity of the final probe, its staining performance and specificity strongly depend on both components. We found correlation between the aggregation efficiency (related to the spirolactonization of fluorophore) and cytotoxicity. Probe optimization allowed us to reach 29 ± 11 nm resolution in stimulated emission depletion (STED) microscopy images of the microtubule network in living human fibroblasts...
April 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29755286/characterisation-of-ground-motion-recording-stations-in-the-groningen-gas-field
#3
Rik Noorlandt, Pauline P Kruiver, Marco P E de Kleine, Marios Karaoulis, Ger de Lange, Antonio Di Matteo, Julius von Ketelhodt, Elmer Ruigrok, Benjamin Edwards, Adrian Rodriguez-Marek, Julian J Bommer, Jan van Elk, Dirk Doornhof
The seismic hazard and risk analysis for the onshore Groningen gas field requires information about local soil properties, in particular shear-wave velocity ( V S ). A fieldwork campaign was conducted at 18 surface accelerograph stations of the monitoring network. The subsurface in the region consists of unconsolidated sediments and is heterogeneous in composition and properties. A range of different methods was applied to acquire in situ V S values to a target depth of at least 30 m. The techniques include seismic cone penetration tests (SCPT) with varying source offsets, multichannel analysis of surface waves (MASW) on Rayleigh waves with different processing approaches, microtremor array, cross-hole tomography and suspension P-S logging...
2018: Journal of Seismology
https://www.readbyqxmd.com/read/29755127/a-novel-long-non-coding-rna-linc-znf469-3-promotes-lung-metastasis-through-mir-574-5p-zeb1-axis-in-triple-negative-breast-cancer
#4
Po-Shun Wang, Cheng-Han Chou, Cheng-Han Lin, Yun-Chin Yao, Hui-Chuan Cheng, Hao-Yi Li, Yu-Chung Chuang, Chia-Ning Yang, Luo-Ping Ger, Yu-Chia Chen, Forn-Chia Lin, Tang-Long Shen, Michael Hsiao, Pei-Jung Lu
Triple-negative breast cancer (TNBC) patients usually lead to poor prognosis and survival because of metastasis. The major sites for TNBC metastasis include the lungs, brain, liver, and bone. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides and have been reported as important regulators in BC metastasis. However, the underlying mechanisms for lncRNAs regulating TNBC metastasis are not fully understood. Here we found that linc-ZNF469-3 was highly expressed in lung-metastatic LM2-4175 TNBC cells and overexpression of linc-ZNF469-3 enhanced invasion ability and stemness properties in vitro and lung metastasis in vivo...
May 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29751600/inflamed-phylloides-tumour-in-a-girl-a-challenging-diagnosis-in-paediatric-breast-lesions
#5
Ilaria Testa, Cristina Salvatori, Marco Prestipino, Maria Elena Laurenti, Paolo Gerli, Giuseppe Di Cara, Nicola Principi, Susanna Esposito, Mirko Bertozzi
Introduction : Phylloides tumours (PTs) are rare fibroepithelial neoplasms that account for 0.3⁻0.9% of all breast tumours. These tumours typically occur in women aged 30⁻70 years. The occurrence of these tumours in older children and adolescents poses particular diagnostic and therapeutic problems. However, early diagnosis is mandatory because although most of the cases of PTs in children are benign, the borderline and malignant cases with potential negative outcomes cannot be excluded. Case presentation : A 12-year-old girl presented at the Paediatric Emergency Department for hyperaemia and warmth of the left breast that occurred a few days prior without fever...
May 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29742392/direct-reprogramming-of-mouse-fibroblasts-into-functional-skeletal-muscle-progenitors
#6
Ori Bar-Nur, Mattia F M Gerli, Bruno Di Stefano, Albert E Almada, Amy Galvin, Amy Coffey, Aaron J Huebner, Peter Feige, Cassandra Verheul, Priscilla Cheung, Duygu Payzin-Dogru, Sylvain Paisant, Anthony Anselmo, Ruslan I Sadreyev, Harald C Ott, Shahragim Tajbakhsh, Michael A Rudnicki, Amy J Wagers, Konrad Hochedlinger
Skeletal muscle harbors quiescent stem cells termed satellite cells and proliferative progenitors termed myoblasts, which play pivotal roles during muscle regeneration. However, current technology does not allow permanent capture of these cell populations in vitro. Here, we show that ectopic expression of the myogenic transcription factor MyoD, combined with exposure to small molecules, reprograms mouse fibroblasts into expandable induced myogenic progenitor cells (iMPCs). iMPCs express key skeletal muscle stem and progenitor cell markers including Pax7 and Myf5 and give rise to dystrophin-expressing myofibers upon transplantation in vivo...
May 8, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29721185/an-epigenetic-regulator-related-score-episcore-predicts-survival-in-patients-with-diffuse-large-b-cell-lymphoma-and-identifies-patients-who-may-benefit-from-epigenetic-therapy
#7
Vanessa Szablewski, Caroline Bret, Alboukadel Kassambara, Julie Devin, Guillaume Cartron, Valérie Costes-Martineau, Jérôme Moreaux
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma and shows considerable clinical and biological heterogeneity. Much research is currently focused on the identification of prognostic markers for more specific patients' risk stratification and on the development of therapeutic approaches to improve the long-term outcome. Epigenetic alterations are involved in various cancers, including lymphoma. Interestingly, epigenetic alterations are reversible and drugs to target some of them have been developed...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29714038/the-force-and-stiffness-of-myosin-motors-in-the-isometric-twitch-of-a-cardiac-trabecula-and-the-effect-of-the-extracellular-calcium-concentration
#8
Francesca Pinzauti, Irene Pertici, Massimo Reconditi, Theyencheri Narayanan, Ger J M Stienen, Gabriella Piazzesi, Vincenzo Lombardi, Marco Linari, Marco Caremani
KEY POINTS SUMMARY: -Fast sarcomere-level mechanics in intact trabeculae, which allows the definition of the mechano-kinetic properties of cardiac myosin in situ, is a fundamental tool to understand the molecular mechanisms of heart performance and regulation, but also to investigate the mechanisms of the cardiomyopathy-causing mutations in the myosin and test small molecules for therapeutic interventions. -The approach has been applied to measure the stiffness and the force of the myosin motor and the fraction of motors attached during isometric twitches of electrically paced trabeculae under different extracellular Ca2+ concentrations...
April 30, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29707540/lymphoma-and-lymphomagenesis-in-primary-sj%C3%A3-gren-s-syndrome
#9
REVIEW
Alessia Alunno, Maria Comasia Leone, Roberto Giacomelli, Roberto Gerli, Francesco Carubbi
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease mainly affecting exocrine glands and leading to impaired secretory function. The clinical picture is dominated by signs and symptoms of mucosal dryness and the course of the disease is mild and indolent in the majority of cases. However, a subgroup of patients can also experience extraglandular manifestations that worsen the disease prognosis. pSS patients are consistently found to have a higher risk of developing non-Hodgkin lymphoma (NHL) compared with patients with other autimmune disorders and to the general population...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29705878/comparative-validation-of-amperometric-and-optical-analyzers-of-dissolved-oxygen-a-case-study
#10
Irja Helm, Gerli Karina, Lauri Jalukse, Todd Pagano, Ivo Leito
A comprehensive comparative validation for two different types of dissolved oxygen (DO) analyzers, amperometric and optical, is presented on two representative commercial DO analyzers. A number of performance characteristics were evaluated including drift, intermediate precision, accuracy of temperature compensation, accuracy of reading (under different measurement conditions), linearity, flow dependence of the reading, repeatability (reading stability), and matrix effects of dissolved salts. The matrix effects on readings in real samples were evaluated by analyzing the dependence of the reading on salt concentration (at saturation concentration of DO)...
April 28, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29705555/da-9701-on-gastric-motility-in-patients-with-parkinson-s-disease-a-randomized-controlled-trial
#11
Cheol Min Shin, Yoon Jin Lee, Jong-Min Kim, Jee Young Lee, Kyung-Joon Kim, Yoon Jin Choi, Nayoung Kim, Dong Ho Lee
INTRODUCTION: To evaluate the effect of DA-9701, a novel prokinetic drug, on gastric motility evaluated by magnetic resonance imaging in patients with Parkinson's disease (PD). METHODS: Forty PD patients were randomly allocated to receive either domperidone or DA-9701. Their gastric functions were evaluated using magnetic resonance imaging before and after 4-week treatment period. Information on levodopa daily dose, disease duration, and Unified PD Rating Scale scores was collected...
April 21, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29700413/identification-of-the-allosteric-p2x-7-receptor-antagonist-11-c-smw139-as-a-pet-tracer-of-microglial-activation
#12
Bieneke Janssen, Danielle J Vugts, Shane M Wilkinson, Dieter Ory, Sylvie Chalon, Jeroen J M Hoozemans, Robert C Schuit, Wissam Beaino, Esther J M Kooijman, Johan van den Hoek, Mansoor Chishty, Aurélie Doméné, Anke Van der Perren, Alessandro Villa, Adriana Maggi, Ger T Molenaar, Uta Funke, Rostislav V Shevchenko, Veerle Baekelandt, Guy Bormans, Adriaan A Lammertsma, Michael Kassiou, Albert D Windhorst
The P2X7 receptor plays a significant role in microglial activation, and as a potential drug target, the P2X7 receptor is also an interesting target in positron emission tomography. The current study aimed at the development and evaluation of a potent tracer targeting the P2X7 receptor, to which end four adamantanyl benzamide analogues with high affinity for the human P2X7 receptor were labelled with carbon-11. All four analogues could be obtained in excellent radiochemical yield and high radiochemical purity and molar activity, and all analogues entered the rat brain...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29677352/the-economic-burden-of-visual-impairment-and-comorbid-fatigue-a-cost-of-illness-study-from-a-societal-perspective
#13
Wouter Schakel, Hilde P A van der Aa, Christina Bode, Carel T J Hulshof, Ger H M B van Rens, Ruth M A van Nispen
Purpose: To investigate the burden of visual impairment and comorbid fatigue in terms of impact on daily life, by estimating societal costs (direct medical costs and indirect non-health care costs) accrued by these conditions. Methods: This cost-of-illness study was performed from a societal perspective. Cross-sectional data of visually impaired adults and normally sighted adults were collected through structured telephone interviews and online surveys, respectively...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29676634/impact-of-seasonal-winter-air-pollution-on-health-across-the-lifespan-in-mongolia-and-some-putative-solutions
#14
David Warburton, Nicole Warburton, Clarence Wigfall, Ochir Chimedsuren, Delgerzul Lodoisamba, Sereeter Lodoysamba, Badarch Jargalsaikhan
Environmental pollution of the air, water, and soil comprise an increasingly urgent challenge to global health, well-being, and productivity. The impact of environmental pollution arguably has its greatest impact across the lifespan on children, women of childbearing age, and pregnant women and their unborn children, not only because of their vulnerability during development, but also because of their subsequent longevity. Ulaanbaatar, Mongolia, is a highly instructive, perhaps extreme, example of what happens with recent, rapid urbanization...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29663628/exenatide-effects-on-gastric-emptying-and-oral-glucose-appearance-in-plasma-a-quantitative-assessment-using-an-integrative-systems-pharmacology-model
#15
Veronika Voronova, Kirill Zhudenkov, Robert C Penland, David W Boulton, Gabriel Helmlinger, Kirill Peskov
Glucagon-like peptide (GLP)-1 and synthetic GLP-1 receptor agonists (GLP-1RA) slow gastric emptying rate (GER), thereby decreasing the Glucose Rate of Appearance (GluRA) in plasma, which may contribute to postprandial plasma glucose (PPG) stabilization under GLP-1RA treatment. A quantitative systems pharmacology (QSP) approach was used to evaluate the effect of exenatide immediate release (IR), a short-acting GLP-1RA, on GER and GluRA. The proposed model is based on the data from multiple published sources including: (1) GLP-1 and exenatide plasma concentration-time profiles; (2) GER estimates under placebo, GLP-1 or exenatide IR dosing; (3) GluRA measurements upon food intake...
April 16, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29661250/isocitrate-dehydrogenase-1-snail-axis-dysfunction-significantly-correlates-with-breast-cancer-prognosis-and-regulates-cell-invasion-ability
#16
Wen-Shan Liu, Shih-Hsuan Chan, Hong-Tai Chang, Guan-Cheng Li, Ya-Ting Tu, Hui-Hwa Tseng, Ting-Ying Fu, Hui-Yu Chang, Huei-Han Liou, Luo-Ping Ger, Kuo-Wang Tsai
BACKGROUND: The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. However, the expression levels of the IDH protein and their biological function in human breast cancer remain largely unknown. METHODS: In this study, the clinical impact of IDH1 expression on the progression and prognosis of breast cancer was evaluated using immunohistochemistry assay (IHC) of the corresponding tumor-adjacent normal, ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC) tissues from 309 patients with breast ductal carcinoma...
April 16, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29626714/nuclear-receptors-as-potential-drug-targets-in-osteoarthritis
#17
REVIEW
Margaret Man-Ger Sun, Frank Beier, Anusha Ratneswaran
Osteoarthritis is amongst the major causes of disability worldwide, but no medications that can slow or stop progression of this disorder have been identified. Recent evidence suggests roles for a variety of members of the nuclear receptor family of ligand-activated transcription factors in various forms of osteoarthritis. Since nuclear receptors are amongst the major classes of drug targets, these studies suggest that modulators of nuclear receptor activity might provide novel strategies to treat osteoarthritis...
April 4, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29625562/development-and-testing-of-an-online-community-care-platform-for-frail-older-adults-in-the-netherlands-a-user-centred-design
#18
Sarah Willard, Ger Cremers, Yan Ping Man, Erik van Rossum, Marieke Spreeuwenberg, Luc de Witte
BACKGROUND: Recent transitions in long-term care in the Netherlands have major consequences for community-dwelling older adults. A new paradigm expects them to manage and arrange their own care and support as much as possible. Technology can support this shift. A study has been conducted to explore the needs of community-dwelling frail older adults with regard to an online platform. An existing platform was subsequently modified, based upon these needs, resulting in an online community care platform (OCC-platform) comprising of care, health, and communication functions...
April 7, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29624620/clinical-risk-factors-of-extracorporeal-membrane-oxygenation-support-in-older-adults
#19
Te-Chun Yeh, Hsiao-Huang Chang, Luo-Ping Ger, Ju-O Wang, Senyeong Kao, Shung-Tai Ho
BACKGROUND: The ageing population and the expected increase in the number of elderly patients make an evidence-based assessment of Extracorporeal Membrane Oxygenation (ECMO) therapy in old patients progressively more important. Veno-arterial (VA) ECMO results for patient aged <65 years is well known. However, the risk profile and in-hospital prognosis of advanced age patients with ECMO still need more investigation. The aim of this study was to identify risk factors that predicted the outcomes for elderly patients who received VA-ECMO...
2018: PloS One
https://www.readbyqxmd.com/read/29603354/combined-multichannel-intraluminal-impedance-ph-monitoring-should-be-used-to-diagnose-reflux-related-otitis-media-with-effusion-in-children
#20
Ivan Pavić, Irena Babić, Nuša Matijašić, Iva Hojsak
AIMS: This study investigated the diagnostic usefulness of combined multichannel intraluminal impedance-pH monitoring (MII-pH) in children with suspected reflux-related otitis media with effusion (OME) as existing data were scarce. METHODS: This was a prospective study that included children up to seven years of age who underwent MII-pH due to OME lasting more than three months. The study was conducted in the Children's Hospital Zagreb, Croatia, from January 2014 to August 2016...
March 30, 2018: Acta Paediatrica
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