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https://www.readbyqxmd.com/read/29160374/study-of-the-protective-effect-of-dexamethasone-on-cisplatin-induced-ototoxicity-in-rats
#1
Isabelle Oliveira Jatai Capelo, Avner Marcos Alves Batista, Yuri Neyson Ferreira Brito, Krissia Braga Diniz, Gerly Anne de Castro Brito, Marcos Rabelo de Freitas
PURPOSE: To evaluate the ability of dexamethasone to protect against cisplatin (CDDP)-induced ototoxicity. METHODS: Male Wistar rats were divided into the following three groups: 1) Control (C): 6 animals received intraperitoneal (IP) saline solution, 8 ml/kg/day for four days; 2) C + CDDP: 11 animals received 8 ml/kg/day of IP saline and, 90 min after saline administration, 8 mg/kg/day of IP CDDP for four days; and 3) DEXA15 + CDDP: 11 animals received IP dexamethasone 15 mg/kg/day and, 90 min after dexamethasone administration, received 8 mg/kg/day of IP CDDP for four days...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29158308/glioblastoma-multiforme-derived-extracellular-vesicles-drive-normal-astrocytes-towards-a-tumour-enhancing-phenotype
#2
Soliman Oushy, Justin E Hellwinkel, Mary Wang, Ger J Nguyen, Dicle Gunaydin, Tessa A Harland, Thomas J Anchordoquy, Michael W Graner
Glioblastoma multiforme (GBM) is a devastating tumour with abysmal prognoses. We desperately need novel approaches to understand GBM biology and therapeutic vulnerabilities. Extracellular vesicles (EVs) are membrane-enclosed nanospheres released locally and systemically by all cells, including tumours, with tremendous potential for intercellular communication. Tumour EVs manipulate their local environments as well as distal targets; EVs may be a mechanism for tumourigenesis in the recurrent GBM setting. We hypothesized that GBM EVs drive molecular changes in normal human astrocytes (NHAs), yielding phenotypically tumour-promoting, or even tumourigenic, entities...
January 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29146648/economic-evaluation-of-an-e-mental-health-intervention-for-patients-with-retinal-exudative-diseases-who-receive-intraocular-anti-vegf-injections-e-pseye-protocol-for-a-randomised-controlled-trial
#3
Hilde P A van der Aa, Ger H M B van Rens, Frank D Verbraak, Machteld Bosscha, Marc A Koopmanschap, Hannie C Comijs, Pim Cuijpers, Ruth M A van Nispen
INTRODUCTION: Because of the great potential of vascular endothelial growth factor inhibitors (anti-VEGF) for retinal exudative diseases, an increased number of patients receives this treatment. However, during this treatment, patients are subjected to frequent invasive intravitreal injections, and the effects on reversing the process of vision loss are uncertain, which may have negative consequences for patients' mental health. One in three patients experience at least mild symptoms of depression/anxiety...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29140307/practical-and-sustainable-synthesis-of-optically-pure-levocabastine-a-h%C3%A2-receptor-antagonist
#4
Sung Kwon Kang, Dong Hyuk Nam, Jaeseung Ahn, Jaemin Lee, Jaehoon Sim, Jeeyeon Lee, Young-Ger Suh
A practical and sustainable method for the synthesis of levocabastine hydrochloride (1), a H₁ receptor antagonist for the treatment of allergic conjunctivitis, that can be applied to the industrial production of the compound has been developed. Substantial improvements over the previously reported procedure are achieved via efficient preparation of an optically active key intermediate (5) without chiral resolution and with a more effective detosylation, which complements the previous procedure. Notably, our process requires no chromatographic purification and provides levocabastine hydrochloride in greater than 99...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29137419/caspase-3-expression-in-tumorigenesis-and-prognosis-of-buccal-mucosa-squamous-cell-carcinoma
#5
Jer-Shyung Huang, Cheng-Mei Yang, Jyh-Seng Wang, Huei-Han Liou, I-Chien Hsieh, Guan-Cheng Li, Sin-Jhih Huang, Chih-Wen Shu, Ting-Ying Fu, Yun-Chung Lin, Luo-Ping Ger, Pei-Feng Liu
Buccal mucosa squamous cell carcinoma (BMSCC) is the most common oral cancer in Southeast Asia. Caspase-3, a key molecule in regulating apoptosis, promotes the malignancy of various cancers. However, its role in BMSCC is unknown. Herein, we evaluated the association of caspase-3 expression with tumorigenesis and prognosis in BMSCC patients. Immunohistochemical staining indicated that the expression levels of cleaved caspase-3 (p<0.001) and caspase-3 (p<0.001) in 185 BMSCC tissues were significantly higher compared to those in the tumor adjacent normal tissues...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136839/chromisense-a-colourimetric-lab-on-a-disc-sensor-for-chromium-speciation-in-water
#6
G Duffy, I Maguire, Brendan Heery, Pauline Gers, J Ducrée, F Regan
The development of a centrifugal device for quantitative analysis of both chromium (III) and (VI) species in water is reported. ChromiSense is a colourimetric sensor system that has been applied to the measurement of chromium in spiked river water samples. For analysis, the sample is loaded into a reservoir on the disposable microfluidic disc, along with reagents. A centrifugal force is created by spinning the disc to pump liquids through microchannels, causing them to mix and react to form a coloured product...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29133255/high-prevalence-of-barrett-s-esophagus-and-esophageal-squamous-cell-carcinoma-after-repair-of-esophageal-atresia
#7
Floor W T Vergouwe, Hanneke IJsselstijn, Katharina Biermann, Nicole S Erler, René M H Wijnen, Marco J Bruno, Manon C W Spaander
BACKGROUND & AIMS: Esophageal atresia is rare, but improved surgical and intensive care techniques have increased rates of survival in children, so there are now many adults with this disorder. Many patients with esophageal atresia develop gastroesophageal reflux (GER), raising concerns about increased risk of Barrett's esophagus (BE; prevalence of 1.3%-1.6% in general population) and esophageal carcinoma. We assessed the prevalence of BE and esophageal carcinoma in this population. METHODS: We performed a prospective study of 289 patients with esophageal atresia at the Department of Gastroenterology and Hepatology at Erasmus MC University Medical Center in The Netherlands, from May 2012 through March 2017...
November 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29127269/intracerebral-hemorrhage-and-outcome-after-thrombolysis-in-stroke-patients-using-selective-serotonin-reuptake-inhibitors
#8
Jan F Scheitz, Guillaume Turc, Linda Kujala, Alexandros A Polymeris, Mirjam R Heldner, Thomas P Zonneveld, Hebun Erdur, Sami Curtze, Christopher Traenka, Céline Brenière, Roland Wiest, Andrea Rocco, Gerli Sibolt, Henrik Gensicke, Matthias Endres, Nicolas Martinez-Majander, Yannick Béjot, Paul J Nederkoorn, Catherine Oppenheim, Marcel Arnold, Stefan T Engelter, Daniel Strbian, Christian H Nolte
BACKGROUND AND PURPOSE: Selective serotonin-reuptake inhibitors (SSRIs) impair platelet function and have been linked to a higher risk of spontaneous intracerebral hemorrhage-an association that may be augmented by oral anticoagulants (OAC). We aimed to assess whether preadmission treatment with SSRIs in patients with acute ischemic stroke is associated with post-thrombolysis symptomatic intracerebral hemorrhage (sICH) and functional outcome. METHODS: A multicenter retrospective analysis was conducted in prospective registries of patients treated by thrombolysis within 4...
November 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29124051/continuation-of-enteral-nutrition-and-relief-from-vomiting-by-administration-of-a-new-formula-a-case-report
#9
Tetsuro Akashi, Kazuhide Matsumoto, Risa Hashimoto
Gastro-esophageal reflux (GER) is a common and serious complication in patients receiving enteral nutrition, making continuation of enteral nutrition difficult. Semi-solid enteral nutrients were developed to prevent feeding-related GER. Semi-solid enteral nutrients have high viscosity and, therefore, are typically administered through a large-diameter percutaneous endoscopic gastrostomy (PEG) tube. Recently, a new formula (Mermed(®), Mermed Plus(®)) was introduced that uses alginate, which behaves like a gelatin in acidic conditions...
October 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29121288/benefit-and-harm-of-pregabalin-in-acute-pain-treatment-a-systematic-review-with-meta-analyses-and-trial-sequential-analyses
#10
M L Fabritius, C Strøm, S Koyuncu, P Jæger, P L Petersen, A Geisler, J Wetterslev, J B Dahl, O Mathiesen
Pregabalin has demonstrated anti-hyperalgesic properties and was introduced into acute pain treatment in 2001. Our aim was to evaluate the beneficial and harmful effects of pregabalin in postoperative pain management. We included randomized clinical trials investigating perioperative pregabalin treatment in adult surgical patients. The review followed Cochrane methodology, including Grading of Recommendations Assessment, Development, and Evaluation (GRADE), and used trial sequential analyses (TSAs). The primary outcomes were 24 h morphine i...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29119074/case-report-on-a-defective-antibody-response-against-pneumococcal-serotype-9v-in-a-patient-with-a-single-episode-of-pneumonia
#11
Diana van Kessel, Thijs Hoffman, Heleen van Velzen-Blad, Bob Meek, Suzan van Mens, Jan Grutters, Ger Rijkers
Background: Patients with recurrent respiratory tract infections and an impaired response to pneumococcal polysaccharide vaccination are diagnosed with a specific antibody deficiency. In adult patients with pneumococcal pneumonia an impaired antibody response to the infecting pneumococcal serotype can sometimes be found. It is unknown whether these patients are unable to produce an adequate anti-polysaccharide antibody response to pneumococcal vaccination after recovery. Case presentation: The authors describe a case of invasive pneumonia caused by Streptococcus pneumoniae serotype 9V in a previously healthy 35-year-old female...
2017: Pneumonia
https://www.readbyqxmd.com/read/29115423/apoptosis-in-human-liver-carcinoma-caused-by-gold-nanoparticles-in-combination-with-carvedilol-is-mediated-via-modulation-of-mapk-akt-mtor-pathway-and-egfr-faad-proteins
#12
Raimundo F De Araújo, Jonas B Pessoa, Luis J Cruz, Alan B Chan, Emílio De Castro Miguel, Rômulo S Cavalcante, Gerly Anne C Brito, Heloiza Fernada O Silva, Luiz H S Gasparotto, Paulo M M Guedes, Aurigena A Araújo
In cancers, apoptosis signaling pathways and cell survival and growth pathways responsible for resistance to conventional treatments, such as Pi3K/Akt/mTOR and mitogen-activated protein kinase (MAPK) become dysregulated. Recently, alternative treatments to promote tumor cell death have become important. The present study reports on the antitumor and cytoprotective action of gold nanoparticles (GNPs) and carvedilol in combination and in isolated application. Apoptosis was analyzed by FITC/propidium iodide staining flow cytometry; caspase-3, caspase-8, Bcl-2 and MAPK/ERK activity by immunofluorescence microscopy; gene expression of proteins related to cell death as Akt, mTOR, EGFR, MDR1, survivin, FADD and Apaf, by the real-time PCR; and western blot analysis for MAPK/ERK, Akt and mTOR...
October 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29112406/nicrophorusamides-a-and-b-antibacterial-chlorinated-cyclic-peptides-from-a-gut-bacterium-of-the-carrion-beetle-nicrophorus-concolor
#13
Yern-Hyerk Shin, Suhyun Bae, Jaehoon Sim, Joonseong Hur, Shin-Il Jo, Jongheon Shin, Young-Ger Suh, Ki-Bong Oh, Dong-Chan Oh
Nicrophorusamides A and B (1 and 2) were discovered from a rare actinomycete, Microbacterium sp., which was isolated from the gut of the carrion beetle Nicrophorus concolor. The structures of the nicrophorusamides were established as new chlorinated cyclic hexapeptides bearing uncommon amino acid units mainly based on 1D and 2D NMR spectroscopic analysis. The absolute configurations of the amino acid residues 5-chloro-l-tryptophan, d-threo-β-hydroxyasparagine/d-asparagine, l-ornithine, l-allo-isoleucine, d-leucine, and d-valine were determined using Marfey's method and chemical derivatization with 2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl isothiocyanate followed by LC/MS analysis...
November 7, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29105529/re-six-novel-rare-non-synonymous-mutations-for-migraine-without-aura-identified-by-exome-sequencing
#14
Cassie L Albury, Zachary F Gerring, Lyn R Griffiths, Dale R Nyholt, Astrid J Rodriguez-Acevedo
No abstract text is available yet for this article.
November 6, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29094144/accuracy-of-prehospital-triage-in-selecting-severely-injured-trauma-patients
#15
Frank J Voskens, Eveline A J van Rein, Rogier van der Sluijs, Roderick M Houwert, Robert Anton Lichtveld, Egbert J Verleisdonk, Michiel Segers, Ger van Olden, Marcel Dijkgraaf, Luke P H Leenen, Mark van Heijl
Importance: A major component of trauma care is adequate prehospital triage. To optimize the prehospital triage system, it is essential to gain insight in the quality of prehospital triage of the entire trauma system. Objective: To prospectively evaluate the quality of the field triage system to identify severely injured adult trauma patients. Design, Setting, and Participants: Prehospital and hospital data of all adult trauma patients during 2012 to 2014 transported with the highest priority by emergency medical services professionals to 10 hospitals in Central Netherlands were prospectively collected...
November 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29090865/prospective-evaluation-of-surgical-management-of-sliding-hiatal-hernia-and-gastroesophageal-reflux-in-dogs
#16
Philipp D Mayhew, Stanley L Marks, Rachel Pollard, William T N Culp, Philip H Kass
OBJECTIVE: To evaluate response to surgical management of sliding hiatal hernia (SHH) and gastroesophageal reflux (GER) in dogs using standardized clinical scoring, videofluoroscopic swallow studies, and impedance planimetry. STUDY DESIGN: Prospective clinical trial. ANIMALS: A total of 17 client-owned dogs. METHODS: Dogs were included if they had clinical signs and videofluoroscopic evidence of SHH and/or GER. Owners were asked to complete a standardized canine dysphagia assessment tool (CDAT) preoperatively and postoperatively...
November 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29075281/leptosphaeria-maculans-alters-glucosinolate-profiles-in-blackleg-disease-resistant-and-susceptible-cabbage-lines
#17
Arif Hasan Khan Robin, Go-Eun Yi, Rawnak Laila, Mohammad Rashed Hossain, Jong-In Park, Hye R Kim, Ill-Sup Nou
Blackleg, a fungal disease caused by Leptosphaeria maculans, is one of the most devastating diseases of Brassica crops worldwide. Despite notable progress elucidating the roles of glucosinolates in pathogen defense, the complex interaction between B. oleracea (cabbage) and L. maculans infection that leads to the selective induction of genes involved in glucosinolate production and subsequent modulation of glucosinolate profiles remains to be fully understood. The current study was designed to identify glucosinolate-biosynthesis genes induced by L...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29072012/-effect-of-electroacupuncture-intervention-on-gastrointestinal-motility-and-expression-of-insulin-like-growth-factor-1-and-its-receptor-proteins-in-gastric-antrum-in-diabetic-gastroparesis-rats
#18
Jian-Wen Yang, Yan Peng, Hai-Jiao Chen, Cheng-Cheng Zhang, Wei-Wei Liu, Li Liu, Mi Liu, Ya-Ping Lin
OBJECTIVE: To observe the effect of electroacupuncture (EA) intervention of "Zusanli"(ST 36), etc. on gastrointestinal motility and levels of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1 R) proteins in the gastric antrum in diabetic gastroparesis (DGP) rats, so as to study its mechanism underlying improvement of DGP. METHODS: Fifty SD rats, half male and half female, were randomly allocated to control, model, EA acupoint, EA non-acupoint and medication (metoclopramide) groups (n=10 rats/group)...
August 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29069385/cytokine-autoantibody-screening-in-the-swedish-addison-register-identifies-patients-with-undiagnosed-aps1
#19
Daniel Eriksson, Frida Dalin, Gabriel Nordling Eriksson, Nils Landegren, Matteo Bianchi, Åsa Hallgren, Per Dahlqvist, Jeanette Wahlberg, Olov Ekwall, Ola Winqvist, Sergiu-Bogdan Catrina, Johan Rönnelid, Anna-Lena Hulting, Kerstin Lindblad-Toh, Mohammad Alimohammadi, Eystein S Husebye, Per Morten Knappskog, Gerli Rosengren Pielberg, Sophie Bensing, Olle Kämpe
Context: Autoimmune polyendocrine syndrome type 1 (APS1) is a monogenic disorder that features autoimmune Addison's disease as a major component. Although APS1 accounts for only a small fraction of all Addison's disease cases, it is vital with an early identification of these individuals in order to prevent potentially lethal complications of APS1. Objective: To determine whether available serological and genetic markers are valuable screening tools for the identification of APS1 among patients diagnosed with Addison's disease...
October 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29066468/choosing-wisely-campaign-report-card-and-achievable-benchmarks-of-care-for-children-s-hospitals
#20
Mario Reyes, Evan Paulus, Carla Hronek, Veronica Etinger, Matt Hall, Joyee Vachani, Jennifer Lusk, Christopher Emerson, Patty Huddleson, Ricardo A Quinonez
OBJECTIVES: In 2013, the Society of Hospital Medicine (SHM) released 5 pediatric recommendations for the Choosing Wisely Campaign (CWC). Our goals were to develop a report card on the basis of those recommendations, calculate achievable benchmarks of care (ABCs), and analyze performance among hospitals participating in the Pediatric Health Information System. METHODS: Children hospitalized between January 2013 and September 2015 from 32 Pediatric Health Information System hospitals were studied...
October 24, 2017: Hospital Pediatrics
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