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https://www.readbyqxmd.com/read/27910140/side-effects-of-irinotecan-cpt-11-the-clinically-used-drug-for-colon-cancer-therapy-are-eliminated-in-experimental-animals-treated-with-latex-proteins-from-calotropis-procera-apocynaceae
#1
Nylane Maria Nunes de Alencar, Flávio da Silveira Bitencourt, Ingrid Samantha Tavares de Figueiredo, Patrícia Bastos Luz, Roberto César P Lima-Júnior, Karoline Sabóia Aragão, Pedro Jorge Caldas Magalhães, Gerly Anne de Castro Brito, Ronaldo Albuquerque Ribeiro, Ana Paula Fragoso de Freitas, Marcio Viana Ramos
Intestinal mucositis (IM) is the critical side effect of irinotecan (CPT-11), which is the front-line drug used for the treatment of colorectal cancer. This study aimed to evaluate the effectiveness of latex proteins (LP) from Calotropis procera to prevent IM and diarrhea in animals. Swiss mice were treated daily with saline or LP (1, 5, or 50 mg/kg, i.v.) 24 h prior to CTP-11 (75 mg/kg/4 days, i.p) and for additional 6 days. Animal survival, body weight variation, and diarrhea were registered. After animal sacrifice (day 7 post first injection of CPT-11), intestinal samples were collected to study morphology and inflammatory parameters...
December 2, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27906917/efficacy-and-safety-of-tc-325-hemospraytm-for-non-variceal-upper-gastrointestinal-bleeding-at-middlemore-hospital-the-early-new-zealand-experience
#2
Hannah Giles, Dinesh Lal, Stephen Gerred, Paul Casey, Alasdair Patrick, Derek Luo, Ravinder Ogra
AIMS: A case series to review early experiences with HemosprayTM for a variety of non-variceal upper gastrointestinal bleeding (UGIB) at Middlemore Hospital. METHODS: HemosprayTM was administered therapeutically as first line or rescue at the discretion of the endoscopist. All cases of UGIB requiring HemosprayTM at Middlemore Hospital were identified to the investigator who undertook analysis of electronic and hard copy notes. RESULTS: Between October 2013 and July 2016, 36 patients were treated endoscopically with HemosprayTM...
December 2, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27906752/recent-developments-in-emerging-therapeutic-targets-of-osteoarthritis
#3
Margaret Man-Ger Sun, Frank Beier, Michael A Pest
PURPOSE OF REVIEW: Despite the tremendous individual suffering and socioeconomic burden caused by osteoarthritis, there are currently no effective disease-modifying treatment options. This is in part because of our incomplete understanding of osteoarthritis disease mechanism. This review summarizes recent developments in therapeutic targets identified from surgical animal models of osteoarthritis that provide novel insight into osteoarthritis pathology and possess potential for progression into preclinical studies...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27906052/antibody-responses-to-de-novo-identified-citrullinated-fibrinogen-peptides-in-rheumatoid-arthritis-and-visualization-of-the-corresponding-b-cells
#4
Vijay Joshua, Loes Schobers, Philip J Titcombe, Lena Israelsson, Johan Rönnelid, Monika Hansson, Anca I Catrina, Ger J M Pruijn, Vivianne Malmström
BACKGROUND: Antibodies against citrullinated proteins (ACPA) are common in patients with rheumatoid arthritis (RA). ACPA can appear before disease onset and target many self-antigens. Citrullinated fibrin/fibrinogen represents a classical ACPA target antigen, and mass spectrometry of RA synovial fluid reveals elevated citrullinated (cit) fibrinogen (Fib) peptides compared to non-RA controls. We investigated the extent to which these less-studied peptides represent autoantibody targets and sought to visualize the corresponding cit-Fib-reactive B cells in RA patients...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27901639/results-of-laparoscopic-heller-s-myotomy-for-achalasia-in-children-a-systematic-review-of-the-literature
#5
Maurizio Pacilli, Mark Davenport
INTRODUCTION: Achalasia is a rare disorder in children who are commonly treated by laparoscopic Heller's myotomy (LHM). However, there are no large studies evaluating the results of LHM in the pediatric population, and the need of a concomitant fundoplication remains unclear. The aim of the study is to appraise the results of LHM based on a systematic literature review. MATERIALS AND METHODS: MEDLINE search of the English literature was performed for "achalasia," "children," "laparoscopy," "Heller," "myotomy," and "cardiomyotomy...
November 30, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27899719/a-novel-hypothesis-for-histone-to-protamine-transition-in-bos-taurus-spermatozoa
#6
Gerly Sillaste, Lauris Kaplinski, Riho Meier, Ülle Jaakma, Elo Eriste, Andres Salumets
DNA compaction with protamines in sperm is essential for successful fertilization. However, a portion of sperm chromatin remains less tightly packed with histones, which genomic location and function remain unclear. We extracted and sequenced histone-associated DNA from sperm of nine ejaculates from three bulls. We found that the fraction of retained histones varied between samples but the variance was similar between samples from the same and different individuals. The most conserved regions showed similar abundance across all samples, while in other regions their presence correlated with the size of histone fraction...
November 29, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27899373/influence-of-geolocation-and-ethnicity-on-the-phenotypic-expression-of-primary-sj%C3%A3-gren-s-syndrome-at-diagnosis-in-8310-patients-a-cross-sectional-study-from-the-big-data-sj%C3%A3-gren-project-consortium
#7
Pilar Brito-Zerón, Nihan Acar-Denizli, Margit Zeher, Astrid Rasmussen, Raphaele Seror, Elke Theander, Xiaomei Li, Chiara Baldini, Jacques-Eric Gottenberg, Debashish Danda, Luca Quartuccio, Roberta Priori, Gabriela Hernandez-Molina, Aike A Kruize, Valeria Valim, Marika Kvarnstrom, Damien Sene, Roberto Gerli, Sonja Praprotnik, David Isenberg, Roser Solans, Maureen Rischmueller, Seung-Ki Kwok, Gunnel Nordmark, Yasunori Suzuki, Roberto Giacomelli, Valerie Devauchelle-Pensec, Michele Bombardieri, Benedikt Hofauer, Hendrika Bootsma, Johan G Brun, Guadalupe Fraile, Steven E Carsons, Tamer A Gheita, Jacques Morel, Cristina Vollenveider, Fabiola Atzeni, Soledad Retamozo, Ildiko Fanny Horvath, Kathy Sivils, Thomas Mandl, Pulukool Sandhya, Salvatore De Vita, Jorge Sanchez-Guerrero, Eefje van der Heijden, Virginia Fernandes Moça Trevisani, Marie Wahren-Herlenius, Xavier Mariette, Manuel Ramos-Casals
OBJECTIVES: To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. RESULTS: We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years...
November 29, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27898643/effect-of-different-osmolalities-cho-types-and-cho-on-gastric-emptying-in-humans
#8
Xiaocai Shi, Kristin L Osterberg, Heather Petrie, John R Stofan, Robert Murray
PURPOSE: This study investigated the effect of beverage osmolalities, carbohydrate (CHO) type and CHO concentration on gastric emptying in euhydrated subjects at rest. METHODS: The gastric emptying of water (W), four glucose beverages (2, 4, 6, and 8% glucose: 2G, 4G, 6G, and 8G) and four sucrose beverages (2, 4, 6, and 8% sucrose: 2S, 4S, 6S, and 8S) were determined in eight healthy subjects using the modified George double-sampling technique. Subjects ingested a beverage (7 ml/kg body weight) containing 25-ppm phenol red as quickly as possible (≤1...
November 28, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27890313/laparoscopic-fundoplication-in-neonates-and-young-infants-failure-rate-and-need-for-redo-at-a-high-volume-center
#9
Pablo Laje, Thane A Blinman, Michael L Nance, William H Peranteau
AIM OF THE STUDY: Present the outcomes of patients younger than 2years who underwent laparoscopic fundoplication, highlighting the failure rate and need for redo fundoplication. METHODS: Retrospective review of patients <2years who underwent laparoscopic fundoplication between January 2009 and December 2014. MAIN RESULTS: 458 infants younger than 2years underwent laparoscopic fundoplication in the 6-year period (360 Nissen, 77 Toupet and 21 Thal fundoplications)...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27889462/maternal-and-umbilical-cord-blood-levels-of-mercury-manganese-iron-and-copper-in-southern-taiwan-a-cross-sectional-study
#10
Shih-Hui Huang, Ken-Pen Weng, Ching-Chiang Lin, Chung-Cheng Wang, Charles Tzu-Chi Lee, Luo-Ping Ger, Ming-Tsang Wu
BACKGROUND: The effect of maternal exposure to essential minerals and heavy metals on fetus is an important issue, which affects women around the world. Few data are available on the concentration of both essential minerals and heavy metals in maternal/fetal medicine. The aims of this study were to (1) assess the correlation of mercury (Hg), manganese (Mn), iron (Fe), and copper (Cu) in paired maternal/fetal blood samples, and (2) study potential confounding factors during pregnancy. METHODS: Our study recruited 145 healthy pregnant women with a mean age of 28...
November 23, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27881417/analysis-of-germination-capacity-and-inventarisation-of-germinant-receptor-sub-clusters-of-genome-sequenced-bacillus-cereus-environmental-isolates-and-model-strains
#11
Alicja K Warda, Yinghua Xiao, Jos Boekhorst, Marjon H J Wells-Bennik, Masja N Nierop Groot, Tjakko Abee
: Spore germination of 17 Bacillus cereus food isolates and reference strains was evaluated using flow cytometry analysis in combination with fluorescent staining at a single spore level. This approach allowed for rapid collection of germination data in more than 20 conditions including heat activation of spores, germination in complex media (BHI and TSB), and exposure to saturating concentrations of single amino acids and the combination of alanine and inosine. Whole genome sequence comparison revealed a total of eleven clusters of operons encoded germinant receptors (GRs); GerK, GerI and GerL were present in all strains, whereas GerR, GerS, GerG, GerQ, GerX, GerF, GerW and GerZ (sub)clusters showed a more diverse presence/absence in different strains...
November 23, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27870530/coiled-coil-mediated-activation-of-oligo-arginine-cell-penetrating-peptides
#12
Saskia Bode, Ilmar Kruis, Hans Adams, Wilbert Boelens, Ger Pruijn, Jan Van Hest, Dennis Lowik
A supramolecular approach was undertaken to create functionally activatable cell-penetrating peptides. Two tetra-arginines were assembled into an active cell-penetrating peptide by hetero-dimerizing leucine zippers. Three different leucine zipper pairs were evaluated of which the activation was found to be dependent on the association constant of the coiled-coil peptides. The weaker binding peptides required an additional disulfide linkage to educe cell-penetrating capacity, whereas for the most stable coiled-coil no additional stabilization was needed...
November 21, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27867073/immune-status-assessment-in-adult-lung-transplant-candidates
#13
Diana A van Kessel, Thijs W Hoffman, Heleen van Velzen-Blad, Ed A van de Graaf, Jan C Grutters, Ger T Rijkers
BACKGROUND: Lung transplant recipients have an increased susceptibility to a variety of infections due to immunosuppressive therapy. Current guidelines recommend pneumococcal and other vaccinations, prior to lung transplantation to protect against post-transplant infections, but measurement of the antibody response to vaccination is not advised. Immune status investigation in lung transplant candidates, including the response to pneumococcal polysaccharide vaccination, has not been described...
November 17, 2016: Transplant Immunology
https://www.readbyqxmd.com/read/27866917/prkag3-polymorphisms-associated-with-sporadic-wolff-parkinson-white-syndrome-among-a-taiwanese-population
#14
Ken-Pen Weng, Yeong-Seng Yuh, Shih-Hui Huang, Hsiang-Chiang Hsiao, Huang-Wei Wu, Jen-Hung Chien, Bo-Hau Chen, Shih-Ming Huang, Kuang-Jen Chien, Luo-Ping Ger
BACKGROUND: The aim of this study was to investigate whether mutation in AMP-activated protein kinase (AMPK) subunit genes (PRKAG3-230) is associated with sporadic, isolated Wolff-Parkinson-White (WPW) syndrome. METHODS: This study consisted of 87 patients with symptomatic WPW syndrome and 93 healthy controls. PRKAG3-230 genotypes were determined using real-time polymerase chain reaction assay. Genotype and allele frequencies of PRKAG3-230 between patients with WPW syndrome and healthy controls were ascertained using chi-square test or Fisher exact test when appropriate...
November 17, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27858337/development-and-evaluation-of-a-standardized-elisa-for-the-determination-of-autoantibodies-against-cn-1a-mup44-nt5c1a-in-sporadic-inclusion-body-myositis
#15
Sabine L Kramp, Dmitry Karayev, Guo Shen, Allan L Metzger, Robert I Morris, Eugene Karayev, Yvonne Lam, Richard M Kazdan, Ger J M Pruijn, Sandra Saschenbrecker, Cornelia Dähnrich, Wolfgang Schlumberger
PURPOSE: Sporadic inclusion body myositis (sIBM) is an autoimmune degenerative disease of the muscle, with inflammatory infiltrates and inclusion vacuoles. Its pathogenesis is not fully understood and the diagnosis is hampered by its imprecise characteristics, at times indistinguishable from other idiopathic inflammatory myopathies such as polymyositis and dermatomyositis. The diagnosis may be assisted by the detection of autoantibodies targeting Mup44, a skeletal muscle antigen identified as cytosolic 5'-nucleotidase 1A (cN-1A, NT5C1A)...
December 2016: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/27844370/erfolgs-rezept-%C3%A2-der-praxis-preis-2016-bewerben-sie-sich-jetzt-mit-ihren-ideen-f%C3%A3-r-die-praxis
#16
Ger, Mh
No abstract text is available yet for this article.
November 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27835882/subsite-specific-association-of-dead-box-rna-helicase-ddx60-with-the-development-and-prognosis-of-oral-squamous-cell-carcinoma
#17
Ting-Ying Fu, Chao-Nan Wu, Huei-Cin Sie, Jiin-Tsuey Cheng, Yaoh-Shiang Lin, Huei-Han Liou, Yu-Kai Tseng, Chih-Wen Shu, Kuo-Wang Tsai, Leing-Ming Yen, Hui-Wen Tseng, Ching-Jiunn Tseng, Luo-Ping Ger, Pei-Feng Liu
The clinical significance and biological function of DEXD/H box helicase 60 (DDX60) in oral cancer remains unknown. Herein, we evaluated the association of DDX60 expression with tumorigenesis and the prognosis of oral squamous cell carcinoma (OSCC). DDX60 expression was examined by immunohistochemistry on tissue microarray slides of 494 OSCC patients, including 180 buccal mucosal SCC (BMSCC), 241 tongue SCC (TSCC), and 73 lip SCC (LSCC) patients. DDX60 expression was significantly increased in all three subsites of OSCC compared to its expression in tumor adjacent normal tissues...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27835749/updating-schematic-emotional-facial-expressions-in-working-memory-response-bias-and-sensitivity
#18
Gerly Tamm, Kairi Kreegipuu, Jaanus Harro, Nelson Cowan
It is unclear if positive, negative, or neutral emotional expressions have an advantage in short-term recognition. Moreover, it is unclear from previous studies of working memory for emotional faces whether effects of emotions comprise response bias or sensitivity. The aim of this study was to compare how schematic emotional expressions (sad, angry, scheming, happy, and neutral) are discriminated and recognized in an updating task (2-back recognition) in a representative sample of birth cohort of young adults...
November 8, 2016: Acta Psychologica
https://www.readbyqxmd.com/read/27829290/hsp90-inhibitors-in-the-context-of-heat-shock-and-the-unfolded-protein-response-effects-on-a-primary-canine-pulmonary-adenocarcinoma-cell-line
#19
Arin N Graner, Justin E Hellwinkel, Alex M Lencioni, Helen J Madsen, Tessa A Harland, Paul Marchando, Ger J Nguyen, Mary Wang, Laura M Russell, Lynne T Bemis, Thomas J Anchordoquy, Michael W Graner
BACKGROUND: Agents targeting HSP90 and GRP94 are seldom tested in stressed contexts such as heat shock (HS) or the unfolded protein response (UPR). Tumor stress often activates HSPs and the UPR as pro-survival mechanisms. This begs the question of stress effects on chemotherapeutic efficacy, particularly with drugs targeting chaperones such as HSP90 or GRP94. We tested the utility of several HSP90 inhibitors, including PU-H71 (targeting GRP94), on a primary canine lung cancer line under HS/UPR stress compared to control conditions...
November 9, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27818697/efficacy-and-safety-of-a-natural-remedy-for-the-treatment-of-gastroesophageal-reflux-a-double-blinded-randomized-controlled-study
#20
Umberto Alecci, Francesco Bonina, Andrea Bonina, Luisa Rizza, Santi Inferrera, Carmen Mannucci, Gioacchino Calapai
Gastroesophageal reflux (GER) is a common, chronic, relapsing symptom. Often people self-diagnose and self-treat it even though health-related quality of life is significantly impaired. In the lack of a valid alternative approach, current treatments focus on suppression of gastric acid secretion by the use of proton pump inhibitors (PPIs), but people with GER have a significantly lower response rate to therapy. We designed a randomized double-blinded controlled clinical study to evaluate the efficacy and the safety of a formulation based on sodium alginate/bicarbonate in combination with extracts obtained from Opuntia ficus-indica and Olea europaea associated with polyphenols (Mucosave®; verum), on GER-related symptoms...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
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