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https://www.readbyqxmd.com/read/29327583/asymmetric-total-synthesis-of-3e-pinnatifidenyne-via-abnormally-regioselective-pd-0-catalyzed-endocyclization
#1
Hyun Su Kim, Taewoo Kim, Jungmin Ahn, Hwayoung Yun, Changjin Lim, Jaebong Jang, Jaehoon Sim, Hongchan An, Young-Joon Surh, Jeeyeon Lee, Young-Ger Suh
The asymmetric total synthesis of the marine natural product (+)-(3E)-pinnatifidenyne was accomplished. The key features of the synthesis involve the construction of eight-membered cyclic ether by the abnormally regioselective Pd(0)-catalyzed cyclization, the installation of a double bond in the oxocene skeleton by sequential in situ deconjugative isomerization, and the efficient introduction of the crucial chloride mediated by the substrate-controlled diastereoselective reduction.
January 12, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29324810/course-of-sp-d-ykl-40-ccl18-and-ca-15-3-in-adult-patients-hospitalised-with-community-acquired-pneumonia-and-their-association-with-disease-severity-and-aetiology-a-post-hoc-analysis
#2
Simone M C Spoorenberg, Stefan M T Vestjens, G P Voorn, Coline H M van Moorsel, Bob Meek, Pieter Zanen, Ger T Rijkers, Willem Jan W Bos, Jan C Grutters
BACKGROUND AND AIM: SP-D, YKL-40, CCL18 and CA 15-3 are pulmonary markers that have been extensively investigated in different chronic pulmonary diseases. However, in acute pulmonary diseases, such as community-acquired pneumonia (CAP), little is known about the course of these markers and their relationship with the aetiological agent. The aim of this study was to investigate the course of these four markers in CAP and to study influence of disease severity, aetiology and antibiotic use prior to admission on their course...
2018: PloS One
https://www.readbyqxmd.com/read/29319187/patients-care-dependency-in-mental-health-care-development-of-a-self-report-questionnaire-and-preliminary-correlates
#3
Naline Geurtzen, Ger P J Keijsers, Johan C Karremans, Giel J M Hutschemaekers
OBJECTIVES: Patients' dependency on the therapist or treatment has received little empirical attention. To examine care dependency, we aimed to develop a theory-driven questionnaire based on three hypothetical dimensions (passive-submissive dependency; active-emotional dependency; and lack of perceived alternatives) and to provide a preliminary exploration of several correlates of care dependency. METHOD: Care dependency, perceived social support, therapeutic alliance, remoralization, and symptom severity were measured in a large cross-sectional sample of 742 outpatients with various psychiatric disorders...
January 10, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29319086/iridium-catalysis-reductive-conversion-of-glucan-to-xylan
#4
Martin Jæger Pedersen, Robert Madsen, Mads Hartvig Clausen
By using iridium catalysed dehydrogenative decarbonylation, we converted a partly protected cellobioside into a fully protected xylobioside. We demonstrate good yields with two different aromatic ester protecting groups. The resulting xylobioside was directly used as glycosyl donor in further synthesis of a xylooctaose.
January 10, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29318852/-effects-of-electroacupuncture-on-ultrastructure-of-interstitial-cells-of-cajal-and-stem-cell-factor-kit-signal-pathway-of-gastric-antrum-in-diabetic-gastroparesis-rats
#5
Cheng-Cheng Zhang, Ya-Ping Lin, Yan Peng, Zeng-Hui Yue, Hai-Jiao Chen, Jian-Wen Yang, Wei-Wei Liu, Li Liu
OBJECTIVE: To observe the effects of electroacupuncture (EA) on gastrointestinal motility and the ultrastructure of interstitial cells of Cajal (ICC) and the expressions of c-kit receptor protein and stem cell factor (SCF) mRNA in diabetic gastroparesis (DGP) rats, so as to explore its mechanism. METHODS: Fifty SD rats were randomly divided into normal, model, acupoint, non-acupoint and metoclopramide groups (n=10 rats/group). DGP model was established by intraperitoneal injection of streptozotocin (STZ, 2%), and raised with high-sugar high-fat diet irregularly...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29318104/one-stage-laparoscopic-surgery-for-pulmonary-sequestration-and-hiatal-hernia-in-a-2-year-old-girl
#6
Hisayuki Miyagi, Shohei Honda, Hiromi Hamada, Masashi Minato, Momoko W Ara, Akinobu Taketomi
We herein report a case of one-stage laparoscopic surgery for extralobar pulmonary sequestration (EPS) and hiatal hernia. Our patient was a 2-year-old girl who was diagnosed as a mediastinal mass lesion. Postnatal computed tomography revealed that the mediastinal mass was an EPS. Two weeks after birth, the patient developed gastroesophageal reflux (GER), and esophagography showed a hiatal hernia. At 2 years of age, she underwent one-stage laparoscopic Nissen's fundoplication for GER with resection of the EPS in the posterior mediastinum...
January 2018: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/29314334/wheezing-and-infantile-colic-are-associated-with-neonatal-antibiotic-treatment
#7
Berthe C Oosterloo, Ruurd M van Elburg, Nicole B Rutten, Carin M Bunkers, Clarissa E Crijns, Clemens B Meijssen, Johanna H Oudshoorn, Ger T Rijkers, Cornelis K van der Ent, Arine M Vlieger
BACKGROUND: Cohort studies have suggested that early life antibiotic treatment is associated with increased risk of atopy. We determined whether antibiotic treatment already in the first week of life increases the risk for atopic and non-atopic disorders. METHODS: The INCA study is a prospective observational birth cohort study of 436 term infants, with follow-up of one year. 151 neonates received broad-spectrum antibiotics for suspected neonatal infection (AB+), versus a healthy untreated control group (N=285) (AB-)...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29313647/peer-review-at-the-research-council-of-norway-quality-assurance-or-border-control
#8
Rolf Andreas Markussen, Ger Wackers
No abstract text is available yet for this article.
January 8, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29306510/protective-effects-of-artemisia-campestris-extract-against-gastric-acid-reflux-induced-esophageal-mucosa-injuries
#9
Mohamed-Amine Jabri, Haifa Tounsi, Afifa Abdellaoui, Lamjed Marzouki, Hichem Sebai
Artemisia campestris L. has been widely used in alternative medicine to treat digestive system diseases, particularly gastroesophageal disorders. In the present investigation, we studied the putative protective effect of Artemisia campestris aqueous extract (ACAE) against gastro-esophageal reflux (GER)-induced esophagitis in rats. The experimental ophagitis was induced by the ligation of the pylorus as well as the junction between the forestomach and the corpus. We firstly found that ACAE administration at 100, 200 and 400 mg/kg, b...
January 2, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29301613/testing-olfactory-function-and-mapping-the-structural-olfactory-networks-in-the-brain
#10
Alexander Fjældstad
We perceive the world through our senses. The dependence on these sensory stimuli becomes obvious when we see a visually impaired individual with a guide dog or an individual using sign language. However, individuals with olfactory deficits suffer from a more concealed impairment without any opportunity for diagnostics or treatment in the Danish healthcare system. Around a fifth of the population experience olfactory deficits, of which 1-2% are functionally anosmic. The personal consequences for anosmics can be extensive, lacking not only in hedonic yield related to eating and drinking, but also the socialization during dinners can become niggling...
January 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29289835/antinociceptive-anti-inflammatory-and-toxicological-evaluation-of-semi-synthetic-molecules-obtained-from-a-benzyl-isothiocyanate-isolated-from-moringa-oleifera-lam-in-a-temporomandibular-joint-inflammatory-hypernociception-model-in-rats
#11
Alain Oliveira Dos Santos, Danielle Rocha do Val, Felipe Dantas da Silveira, Francisco Isaac Fernandes Gomes, Hermany Capistrano Freitas, Ellen Lima de Assis, Diana Kelly Castro de Almeida, Igor Iuco Castro da Silva, Francisco Geraldo Barbosa, Jair Mafezoli, Marcos Reinaldo da Silva, Gerly Anne de Castro Brito, Juliana Trindade Clemente-Napimoga, Vicente de Paulo Teixeira de Paulo Teixera Pinto, Gerardo Cristino Filho, Mirna Marques Bezerra, Hellíada Vasconcelos Chaves
Inflammation is a key component of many clinical conditions that affect the temporomandibular joint (TMJ) and Moringa oleifera Lam. has been used to treat inflammatory diseases. Here, we evaluated the toxicological effects on mice of a naturally-occurring isothiocyanate from M. oleifera and its seven analogue molecules. Further, the anti-nociceptive and anti-inflammatory effects on a rat model of TMJ inflammatory hypernociception were assessed. The systemic toxicological profile was determined in mice over a 14-day period: MC-1 1 μg/kg; MC-D1 1 μg/kg, MC-D3 100 μg/kg, MC-D6 1 μg/kg, MC-D7 1 μg/kg, MC-D8 1 μg/kg, MC-D9 10 μg/kg, and MC-H 1 μg/kg...
December 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29288400/anti-inflammatory-and-antiresorptive-effects-of-calendula-officinalis-on-inflammatory-bone-loss-in-rats
#12
Joanna Trycia M Alexandre, Luzia Hermínia Teixeira Sousa, Mario Roberto Pontes Lisboa, Flávia A C Furlaneto, Danielle Rocha do Val, Mirna Marques, Hellíada C Vasconcelos, Iracema Matos de Melo, Renata Leitão, Gerly Anne Castro Brito, Paula Goes
OBJECTIVE: The aim of this work was to evaluate the anti-inflammatory and antiresorptive effects of Calendula officinalis (CLO) on alveolar bone loss (ABL) in rats. MATERIAL AND METHODS: Male Wistar rats were subjected to ABL by ligature with nylon thread around the second upper left molar. The contralateral hemimaxillae were used as control. Rats received saline solution (SAL) or CLO (10, 30, or 90 mg/kg) 30 min before ligature and daily until the 11th day. The maxillae were removed and prepared for macroscopic, radiographic, micro-tomographic, histopathologic, histometric analysis, and immunohistochemical localization of receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG)...
December 29, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29276031/in-a-bed-or-on-the-floor-the-effect-of-realistic-hospital-resuscitation-training-a-randomised-controlled-trial
#13
Troels Mygind-Klausen, André Jæger, Camilla Hansen, Rasmus Aagaard, Lise Qvirin Krogh, Mette Amalie Nebsbjerg, Kristian Krogh, Bo Løfgren
INTRODUCTION: In-hospital cardiac arrest has a poor prognosis and often occurs in patients lying in a hospital bed. A bed mattress is a soft compressible surface that may decrease cardiopulmonary resuscitation (CPR) quality. Often hospital CPR training is performed with a manikin on the floor. AIM: To study CPR quality following realistic CPR training with a manikin in a bed compared with one on the floor. METHODS: We conducted a randomised controlled study...
December 13, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29258605/mir-105-93-3p-promotes-chemoresistance-and-circulating-mir-105-93-3p-acts-as-a-diagnostic-biomarker-for-triple-negative-breast-cancer
#14
Hao-Yi Li, Jui-Lin Liang, Yao-Lung Kuo, Hao-Hsien Lee, Marcus J Calkins, Hong-Tai Chang, Forn-Chia Lin, Yu-Chia Chen, Tai-I Hsu, Michael Hsiao, Luo-Ping Ger, Pei-Jung Lu
BACKGROUND: Triple negative breast cancer (TNBC) lacks both early detection biomarkers and viable targeted therapeutics. Moreover, chemotherapy only produces 20-30% pathologic complete response. Because miRNAs are frequently dysregulated in breast cancer and have broad tissue effects, individual or combinations of circulating miRNAs may serve as ideal diagnostic, predictive or prognostic biomarkers, as well as therapeutic targets. Understanding the role and mechanism of dysregulated miRNAs in TNBC may help to develop novel diagnostic and prognostic strategy for TNBC patients...
December 19, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29251245/telemonitoring-in-patients-with-heart-failure-is-there-a-long-term-effect
#15
Arno J Gingele, Hanspeter Brunner-la Rocca, Bram Ramaekers, Anton Gorgels, Gerjan De Weerd, Johannes Kragten, Vanessa van Empel, Vincent Brandenburg, Hubertus Vrijhoef, Ger Cleuren, Christian Knackstedt, Josiane Jj Boyne
Introduction Evidence suggests that telemonitoring decreases mortality and heart failure (HF)-related hospital admission in patients with HF. However, most studies follow their patients for only several months. Little is known about the long-term effects of telemonitoring after a period of application. Methods In 2007, the TEHAF study was initiated to compare tailored telemonitoring with usual care with respect to time until first HF-related hospital admission. In total, 301 patients completed the study after a follow-up period of one year...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29247123/taurine-chloramine-potentiates-phagocytic-activity-of-peritoneal-macrophages-through-up-regulation-of-dectin-1-mediated-by-heme-oxygenase-1-derived-carbon-monoxide
#16
Seung Hyeon Kim, Xiancai Zhong, Wonki Kim, Kyeojin Kim, Young-Ger Suh, Chaekyun Kim, Yeonsoo Joe, Hun Taeg Chung, Young-Nam Cha, Young-Joon Surh
Resolution of inflammation that occurs after microbial infection or tissue damage is an important physiologic process in maintaining or restoring host homeostasis. Taurine chloramine (TauCl) is formed by a reaction between taurine and hypochlorite in leukocytes, and it is especially abundant in activated neutrophils that encounter an oxidative burst. As neutrophils undergo apoptosis, TauCl is released to the extracellular matrix at the inflamed sites, thereby affecting coexisting macrophages in the inflammatory microenvironment...
December 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29238722/clinical-epidemiological-and-histopathological-features-of-respiratory-involvement-in-rheumatoid-arthritis
#17
REVIEW
Alessia Alunno, Roberto Gerli, Roberto Giacomelli, Francesco Carubbi
Although by definition rheumatoid arthritis (RA) is an articular disorder, it is a systemic disease, and 18-40% of patients experience extra-articular manifestations (EAMs). The involvement of the respiratory system occurs in about 30-40% of RA patients, and in about 10-20% of them it represents the first manifestation of RA. A wide range of pulmonary manifestations are detectable in RA patients, including pulmonary parenchymal disease, pleural involvement, and airway and pulmonary inflammation. The clinical, radiological, and histological spectra of respiratory manifestations in RA reflect chronic immune activation, increased susceptibility to infection (often related to immunosuppressive medications), or direct drug...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29230231/activation-of-the-lrr-receptor-like-kinase-psy1r-requires-transphosphorylation-of-residues-in-the-activation-loop
#18
Christian B Oehlenschlæger, Lotte B A Gersby, Nagib Ahsan, Jesper T Pedersen, Astrid Kristensen, Tsvetelina V Solakova, Jay J Thelen, Anja T Fuglsang
PSY1R is a leucine-rich repeat (LRR) receptor-like kinase (RLK) previously shown to act as receptor for the plant peptide hormone PSY1 (peptide containing sulfated tyrosine 1) and to regulate cell expansion. PSY1R phosphorylates and thereby regulates the activity of plasma membrane-localized H+-ATPases. While this mechanism has been studied in detail, little is known about how PSY1R itself is activated. Here we studied the activation mechanism of PSY1R. We show that full-length PSY1R interacts with members of the SERK co-receptor family in planta...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29204582/publication-trends-in-obstructive-sleep-apnea-evidence-of-need-for-more-evidence
#19
R Araslanova, J Paradis, B W Rotenberg
Objective: Published research in obstructive sleep apnea (OSA) appears limited despite OSA being a highly prevalent adult and pediatric disease leading to many adverse outcomes if left untreated. We aimed to quantify the deficit in OSA scientific literature in order to provide a novel way of identifying gaps in knowledge and a need for further research inquiry. Methods: This was a Bibliometric analysis study. Using Ovid Medline database we analyzed and compared research output (medical and surgical) between adult OSA and similarly prevalent chronic conditions (Type II diabetes (T2DM), coronary artery disease (CAD) and osteoarthritis (OA)) from December 2016 up to fifty years prior...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29201792/does-chicago-classification-address-symptom-correlation-with-high-resolution-esophageal-manometry
#20
Mayank Jain, Melpakkam Srinivas, Piyush Bawane, Jayanthi Venkataraman
Aim: To assess the correlation of symptoms with findings on esophageal high-resolution manometry (HRM) in Indian patients. Materials and methods: Prospective data collection of all patients undergoing esophageal manometry was done at two centers in India-Indore and Chennai-over a period of 18 months. Symptom profile of the study group was divided into four: Motor dysphagia, noncardiac chest pain (NCCP), gastroesophageal reflux (GER), and esophageal belchers. The symptoms were correlated with manometric findings...
July 2017: Euroasian Journal of Hepato-Gastroenterology
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