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https://www.readbyqxmd.com/read/28913905/clinicopathological-study-of-lip-cancer-a-retrospective-hospital-based-study-in-taiwan
#1
Hui-Wen Tseng, Huei-Han Liou, Kuo-Wang Tsai, Luo-Ping Ger, Yow-Ling Shiue
To evaluate the clinicopathological characteristics, high-risk lifestyle factors (HRLF: chronic exposure to sun, betel quid, alcohol, and tobacco), and prognostic factors of lip cancer. The hospital records of patients with pathologically confirmed lip squamous cell carcinoma (LSCC, n = 112) and lip basal cell carcinoma (LBCC, n = 21) were reviewed. Differences in clinicopathological characteristics between LSCC and LBCC, upper and lower lip, and status of second primary tumors were compared by chi-square test and logistic regression...
September 15, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28905505/biallelic-variants-in-wars2-encoding-mitochondrial-tryptophanyl-trna-synthase-in-six-individuals-with-mitochondrial-encephalopathy
#2
Saskia B Wortmann, Sharita Timal, Hanka Venselaar, Liesbeth T Wintjes, Robert Kopajtich, René G Feichtinger, Carla Onnekink, Mareike Mühlmeister, Ulrich Brandt, Jan A Smeitink, Joris A Veltman, Wolfgang Sperl, Dirk Lefeber, Ger Pruijn, Vesna Stojanovic, Peter Freisinger, Francjan V Spronsen, Terry Gj Derks, Hermine E Veenstra-Knol, Johannes A Mayr, Agnes Rötig, Mark Tarnopolsky, Holger Prokisch, Richard J Rodenburg
Mitochondrial protein synthesis involves an intricate interplay between mitochondrial DNA encoded RNAs and nuclear DNA encoded proteins, such as ribosomal proteins and aminoacyl-tRNA synthases. Eukaryotic cells contain 17 mitochondria-specific aminoacyl-tRNA synthases. WARS2 encodes mitochondrial tryptophanyl-tRNA synthase (mtTrpRS), a homodimeric class Ic enzyme (mitochondrial tryptophan-tRNA ligase; EC 6.1.1.2). Here, we report six individuals from five families presenting with either severe neonatal onset lactic acidosis, encephalomyopathy and early death or a later onset, more attenuated course of disease with predominating intellectual disability...
September 14, 2017: Human Mutation
https://www.readbyqxmd.com/read/28894197/a-multi-institutional-comparison-of-dynamic-contrast-enhanced-magnetic-resonance-imaging-parameter-calculations
#3
Rachel B Ger, Abdallah S R Mohamed, Musaddiq J Awan, Yao Ding, Kimberly Li, Xenia J Fave, Andrew L Beers, Brandon Driscoll, Hesham Elhalawani, David A Hormuth, Petra J van Houdt, Renjie He, Shouhao Zhou, Kelsey B Mathieu, Heng Li, Catherine Coolens, Caroline Chung, James A Bankson, Wei Huang, Jihong Wang, Vlad C Sandulache, Stephen Y Lai, Rebecca M Howell, R Jason Stafford, Thomas E Yankeelov, Uulke A van der Heide, Steven J Frank, Daniel P Barboriak, John D Hazle, Laurence E Court, Jayashree Kalpathy-Cramer, Clifton D Fuller
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides quantitative metrics (e.g. K(trans), ve) via pharmacokinetic models. We tested inter-algorithm variability in these quantitative metrics with 11 published DCE-MRI algorithms, all implementing Tofts-Kermode or extended Tofts pharmacokinetic models. Digital reference objects (DROs) with known K(trans) and ve values were used to assess performance at varying noise levels. Additionally, DCE-MRI data from 15 head and neck squamous cell carcinoma patients over 3 time-points during chemoradiotherapy were used to ascertain K(trans) and ve kinetic trends across algorithms...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28884564/pattern-of-food-intolerance-in-patients-with-gastro-esophageal-reflux-symptoms
#4
Michele Caselli, Natalina Lo Cascio, Stefano Rabitti, Leonardo H Eusebi, Elena Zeni, Cecilia Soavi, Francesca Cassol, Giovanni Zuliani, Rocco M Zagari
BACKGROUND: Many food items have been involved in gastro-esophageal reflux disease pathogenesis and dietary modification has been proposed as first-line treatment. Test-based exclusion diets have shown to significantly reduce reflux symptoms. we aimed to assess the patterns of food intolerance in a series of patients with typical gastro-esophageal reflux symptoms (GERS). METHODS: We retrospectively evaluated all patients with typical reflux symptoms, attending the Centre Study Association on Food Intolerance and Nutrition of Ferrara from January 2010 to October 2015, who resulted positive to at least one food item at the leucocytotoxic test...
September 7, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28881892/influence-of-esophagectomy-on-the-gastroesophageal-reflux-in-patients-with-esophageal-cancer
#5
D Kim, Y W Min, J G Park, H Lee, B-H Min, J H Lee, P-L Rhee, J J Kim, J I Zo
This study aims to assess the influence of esophagectomy with gastric transposition on the gastroesophageal reflux (GER) and gastric acidity in patients with esophageal cancer. Data on 53 esophageal cancer patients who underwent 24-hour impedance-pH monitoring after esophagectomy were retrospectively analyzed. We used a solid-state esophageal pH probe in which the esophageal pH sensor is placed 1.5 cm distal to the upper esophageal sphincter and the gastric pH sensor is located 15 cm distal to the esophageal pH channel...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28875276/epigenetic-and-genetic-landscape-of-uterine-leiomyomas-a-current-view-over-a-common-gynecological-disease
#6
Antonio Simone Laganà, Daniele Vergara, Alessandro Favilli, Valentina Lucia La Rosa, Andrea Tinelli, Sandro Gerli, Marco Noventa, Amerigo Vitagliano, Onofrio Triolo, Agnese Maria Chiara Rapisarda, Salvatore Giovanni Vitale
PURPOSE: Despite the numerous studies on the factors involved in the genesis and growth of uterine leiomyomas, the pathogenesis of these tumors remains unknown. Intrinsic abnormalities of the myometrium, abnormal myometrial receptors for estrogen, and hormonal changes or altered responses to ischemic damage during the menstrual period may be responsible for the initiation of (epi)genetic changes found in these tumors. Considering these elements, we aimed to offer an overview about epigenetic and genetic landscape of uterine leiomyomas...
September 5, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28870218/respiratory-problems-in-children-with-esophageal-atresia-and-tracheoesophageal-fistula
#7
Federica Porcaro, Laura Valfré, Lelia Rotondi Aufiero, Luigi Dall'Oglio, Paola De Angelis, Alberto Villani, Pietro Bagolan, Sergio Bottero, Renato Cutrera
BACKGROUND: Children with congenital esophageal atresia (EA) and tracheoesophageal fistula (TEF) have chronic respiratory symptoms including recurrent pneumonia, wheezing and persistent cough. The aim of this study is to describe the clinical findings of a large group of children with EA and TEF surgically corrected and the instrumental investigation to which they have undergone in order to better understand the patient's needs and harmonize the care. METHODS: A retrospective data collection was performed on 105 children with EA and TEF followed at Department of Pediatric Medicine of Bambino Gesù Children's Hospital (Rome, Italy) between 2010 and 2015...
September 5, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28867645/5-fluorouracil-induces-inflammation-and-oxidative-stress-in-the-major-salivary-glands-affecting-salivary-flow-and-saliva-composition
#8
Luana E Bomfin, Cíntia M Braga, Thais A Oliveira, Conceição S Martins, Danielle A Foschetti, Ana A Q A Santos, Deiziane V S Costa, Renata F C Leitão, Gerly A C Brito
This study aimed to elucidate the effect of 5-fluorouracil (5-FU) on the histological aspects of the major salivary glands, salivary flow and saliva composition using an established oral mucositis model in hamsters. Oral mucositis was induced by two intraperitoneal administrations of 5-FU in two consecutive days (60 and 40mg/kg), followed by cheek pouch mucosa scratch, on day 4. The Pilocarpine-stimulated salivary flow was measured 4 and 10days after the first 5-FU injection. Salivary glands were harvested for histopathological analysis, measurement of inflammatory cells, quantification of pro-inflammatory cytokines (TNF-α and IL-1β), investigation of cell death and cell proliferation...
September 1, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28865424/prevalence-pattern-and-risk-factors-of-retinal-vein-occlusion-in-an-elderly-population-in-nepal-the-bhaktapur-retina-study
#9
Raba Thapa, Sanyam Bajimaya, Govinda Paudyal, Shankar Khanal, Stevie Tan, Suman S Thapa, Ger van Rens
BACKGROUND: This study aims to explore the prevalence, pattern and risk factors of retinal vein occlusion (RVO) in an elderly population of Nepal. METHOD: One thousand eight hundred sixty subjects of age 60 years and above were enrolled in a population-based, cross-sectional study. Detailed history, visual acuity, anterior segment and posterior segment examinations were done. Blood pressure, non-fasting blood sugar, body mass index and abdominal girth were measured...
September 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28860166/effects-of-anti-inflammatory-nsaid-treatment-on-human-tendinopathic-tissue
#10
Katja Maria Heinemeier, Tommy F Øhlenschlæger, Ulla Ramer Mikkelsen, Freja Sønder, Peter Schjerling, Rene Brüggebusch Svensson, Michael Kjaer
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat tendinopathy, but evidence for this treatment is lacking, and little is known regarding effects of NSAIDs on human tendinopathic tendon. This study investigated effects of NSAID treatment (ibuprofen) on human tendinopathic tendon, with changes in gene expression as the primary outcome, and tendon pain, function and blood flow as secondary outcomes. Twenty-six adults (16 male, 10 female) diagnosed with chronic Achilles tendinopathy were randomized to one-week treatment with ibuprofen (600mgx3/day) (n=13) or placebo (n=13) (double-blinded)...
August 31, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28851468/persistent-fifth-aortic-arch-the-great-pretender-in-clinical-practice
#11
David F A Lloyd, S Y Ho, Kuberan Pushparajah, Subhasis Chakraborty, Mohamed Nasser, Hideki Uemura, Rodney Franklin, Alan G Magee
Persistence of the embryonic "fifth aortic arch" in postnatal life is a rare, enigmatic - and at times controversial - condition, with variable anatomical forms and physiological consequences. First described in humans over 40 years ago by Van Praagh, the condition was labelled the "great pretender" by Gerlis 25 years later, because of its apparent propensity to mimic anatomically similar structures. Despite many subsequent case reports citing the condition, the true developmental origin of these structures remains unresolved, and has been the subject of debate among embryologists for more than a century...
August 30, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28847008/effects-of-metformin-on-inflammation-oxidative-stress-and-bone-loss-in-a-rat-model-of-periodontitis
#12
Aurigena Antunes de Araújo, Aline de Sousa Barbosa Freitas Pereira, Caroline Addison Carvalho Xavier de Medeiros, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitão, Lorena de Souza Araújo, Paulo Marcos Matta Guedes, Sarah Hiyari, Flávia Q Pirih, Raimundo Fernandes de Araújo Júnior
AIM: To evaluate the effects of metformin (Met) on inflammation, oxidative stress, and bone loss in a rat model of ligature-induced periodontitis. MATERIALS & METHODS: Male albino Wistar rats were divided randomly into five groups of twenty-one rats each, and given the following treatments for 10 days: (1) no ligature + water, (2) ligature + water, (3) ligature + 50 mg/kg Met, (4) ligature + 100 mg/kg Met, and (5) ligature + 200 mg/kg Met. Water or Met was administered orally...
2017: PloS One
https://www.readbyqxmd.com/read/28840856/response-to-the-importance-of-immunosuppression-as-risk-and-prognostic-factor-for-non-melanoma-skin-cancers
#13
R C Gerring, C T Ott, J M Curry, Z B Sargi, S T Wester
No abstract text is available yet for this article.
August 25, 2017: Eye
https://www.readbyqxmd.com/read/28838784/non-invasive-diagnosis-for-differentiating-non-alcoholic-steatohepatitis-from-simple-steatosis-a-meta-analysis-and-systematic-review
#14
Pauline Verhaegh, Roisin Bavalia, Bjorn Winkens, Ad Masclee, Daisy Jonkers, Ger Koek
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a rapidly increasing health problem. Liver biopsy is the most sensitive test to differentiate between non-alcoholic steatohepatitis (NASH) and simple steatosis (SS), but non-invasive diagnostics are warranted. We performed a systematic review on non-invasive tests for differentiating NASH from SS, focusing on blood markers. METHODS: A systematic search in PubMed, Medline and Embase (1990-2016) using defined keywords, limited to full-text papers in English and human adults, resulted in 2608 hits...
August 21, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28836617/hypertension-as-a-cardiovascular-risk-factor-in-autoimmune-rheumatic-diseases
#15
REVIEW
Elena Bartoloni, Alessia Alunno, Roberto Gerli
Evidence for the increased risk of cardiovascular morbidity and mortality in patients with chronic inflammatory and systemic autoimmune diseases has accumulated during the past 15 years. In these patients, an interplay between several mechanisms, including premature acceleration of subclinical atherosclerotic damage, inflammation, and dysregulation of the immune system, is involved in the induction and progression of atherosclerosis. Moreover, traditional cardiovascular risk factors are also likely to contribute, at least in part, to the excess cardiovascular risk...
August 24, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28833721/from-a-diphosphanegermylene-to-nickel-palladium-and-platinum-complexes-containing-germyl-pgep-pincer-ligands
#16
Javier A Cabeza, Lucía Álvarez-Rodríguez, Javier Brugos, Pablo García-Álvarez, Enrique Pérez-Carreño
The PGeP pincer-type germylene Ge(NCH2PtBu2)C6H4 (1) has been used to prepare a family group 10 metal complexes, namely, [MCl{κ3P,Ge,P-GeCl(NCH2PtBu2)2C6H4}] (M = Ni (2Ni), Pd (2Pd), Pt (2Pt)), featuring a chloridogermyl PGeP pincer ligand and a Cl-Ge-M-Cl bond sequence. Their reactivity is not initially centered on the metal atom but on their Ge atom. 2Ni and 2Pd easily led to the hydrolyzed products [Ni2Cl2{μ-(κ3P,Ge,P-Ge(NCH2PtBu2)2C6H4)2O}], which features a Cl-Ni-Ge-O-Ge-Ni-Cl bond sequence, and [PdCl{κ3P,Ge,P-Ge(OH)(NCH2PtBu2)2C6H4}], which contains a hydroxidogermyl PGeP pincer ligand (2Pt is reluctant to undergo hydrolysis)...
August 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28831589/functional-and-quality-of-life-outcome-after-non-operatively-managed-proximal-humeral-fractures
#17
Ronnart N Kruithof, Henk A Formijne Jonkers, Denise J C van der Ven, Ger D J van Olden, Tim K Timmers
BACKGROUND: Fractures of the proximal humerus are common and most often treated non-operatively. However, long-term follow-up studies focusing on functional results and quality of life in patients after this type of fracture are scarce. The primary aim of this study is to report the long-term functional and quality of life outcome in patients with a proximal humeral fracture. MATERIALS AND METHODS: A retrospective analysis of all consecutive patients undergoing non-operative treatment for a proximal humeral fracture in a level 2 trauma centre between January 2000 and December 2013 was performed...
August 22, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28827640/intestinal-colonisation-patterns-in-breastfed-and-formula-fed-infants-during-the-first-12-weeks-of-life-reveal-sequential-microbiota-signatures
#18
Harro M Timmerman, Nicole B M M Rutten, Jos Boekhorst, Delphine M Saulnier, Guus A M Kortman, Nikhat Contractor, Martin Kullen, Esther Floris, Hermie J M Harmsen, Arine M Vlieger, Michiel Kleerebezem, Ger T Rijkers
The establishment of the infant gut microbiota is a highly dynamic process dependent on extrinsic and intrinsic factors. We characterized the faecal microbiota of 4 breastfed infants and 4 formula-fed infants at 17 consecutive time points during the first 12 weeks of life. Microbiota composition was analysed by a combination of 16S rRNA gene sequencing and quantitative PCR (qPCR). In this dataset, individuality was a major driver of microbiota composition (P = 0.002) and was more pronounced in breastfed infants...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28826660/anti-citrullinated-peptide-antibodies-profiling-in-established-rheumatoid-arthritis
#19
Maria Laura Manca, Alessia Alunno, Claudia D'Amato, Onelia Bistoni, Ilaria Puxeddu, Roberto Gerli, Paola Migliorini, Federico Pratesi
OBJECTIVES: Anti-citrullinated protein/peptide antibodies (ACPA) represent an important tool for the diagnosis of rheumatoid arthritis (RA) and the presence of multiple ACPA specificities is highly correlated with the evolution towards RA. However, little is known about the association of single specificities with disease manifestations and response to therapy in established RA. The aim of this work is to evaluate in a retrospective study the clinico-serological association of ACPA detected using VCP1 and VCP2 (EBV-derived citrullinated peptides) and HCP1 and HCP2 (histone-H4-derived citrulinated peptides) in established RA...
August 4, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28808763/characteristics-of-gastroesophageal-reflux-in-pediatric-patients-with-neurological-impairment
#20
Hisayoshi Kawahara, Yuko Tazuke, Hideki Soh, Noriaki Usui, Hiroomi Okuyama
PURPOSE: To clarify the characteristics of gastroesophageal reflux (GER) in pediatric patients with neurological impairment (NI). METHODS: Twenty-six patients with NI, 1-17-year-old, fed via a nasogastric tube were categorized based on the absence (group I) or presence (group II) of abnormal GER, defined with multichannel intraluminal impedance-pH monitoring as %time with an esophageal pH <4.0 being ≥5.0% or number of liquid/mixed bolus reflux events(RE) >70 in 24 h...
August 14, 2017: Pediatric Surgery International
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