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Controlled ovarian hyperstimulation

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https://www.readbyqxmd.com/read/29749659/roles-of-methyltrienolone-r1881-in-akts-and-ar-expression-patterns-of-cultured-granulosa-lutein-cells
#1
Saeid Nekoonam, Mohammad Naji, Keywan Mortezaee, Fardin Amidi
AR-mediated androgen signaling plays a key role in female reproductive system. Granulosa-lutein cells (GCs) are the main sites for expression of androgen receptor (AR). There is also a close relation between AKT signaling and AR. Here, we assayed the role for a synthetic AR ligand methyltrienolone (R1881) in expressions of AKTs and AR. Controlled ovarian hyperstimulation (COH) was performed in 20 normal women. Mural GCs were isolated by filtration method, cultured, and passaged. Then, the cells were starved for 48 h with 10% charcoal stripped FBS...
May 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29696918/-efficacy-of-acupuncture-as-adjunctive-treatment-on-infertility-patients-with-polycystic-ovary-syndrome
#2
Juan Xu, Yu Zuo
OBJECTIVE: To observe the efficacy differences between acupuncture combined with medication and medication alone for infertility patients with polycystic ovary syndrome (PCOS). METHODS: According to random number table, a total of 60 infertility patients with PCOS were randomly assigned into an observation group and a control group, 30 cases in each one. The patients in the control group were treated with diane-35 from the 3rd day into menstruation, and one menstrual cycle was taken as a session of treatment...
April 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29696192/the-dual-trigger-study-rationale-and-study-design-of-a-prospective-double-blind-randomized-clinical-trial-comparing-pregnancy-rates-after-co-administration-of-low-dose-hcg-at-the-time-of-gnrh-agonist-trigger-or-35-h-later-for-the-prevention-of-ohss
#3
Daniel Griffin, Claudio Benadiva, Tara Budinetz, Carolina Sueldo, Andrea DiLuigi, John Nulsen, Lawrence Engmann
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of controlled ovarian stimulation. The use of gonadotropin releasing hormone (GnRH) agonist for the trigger of oocyte maturation is effective in the prevention of OHSS although it may result in a lower pregnancy rate. The use of adjuvant low dose human chorionic gonadotropin (hCG) at the time of trigger or at the time of oocyte retrieval may improve pregnancy rates. The goal of this dual trigger study is to evaluate the safety and efficacy of the use of low dose hCG administered at the time of GnRH agonist trigger or 35 h later as well as the potential impact on pregnancy rates...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29681717/luteinizing-hormone-receptor-gene-and-regulator-of-g-protein-signaling-2-gene-expression-level-and-association-with-oocyte-maturity-in-in-vitro-fertilization-intracytoplasmic-sperm-injection-cycle
#4
Thanik Chokjirawat, Mutchuporn Sukpresert, Wicharn Choktanasiri, Wanwisa Waiyaput, Duangporn Saengwimol, Aruchalean Taweewongsounton, Tanjitti Pongrujikorn, Chonthicha Satirapod
Aims: The aim is to study the relation and distribution in gene expression level of the luteinizing hormone receptor (LHR) gene and regulator of G-protein signaling 2 (RGS2) gene expression with oocyte maturation. Setting and Design: This cross-sectional study was undertaken in an instruction-based tertiary care infertility unit, department of obstetrics and gynecology. Materials and Methods: After controlled ovarian hyperstimulation, cumulus granulosa cells (CCs) from 59 oocytes among 18 women being treated by in vitro fertilization/intracytoplasmic sperm injection cycle technique from November 2015 to January 2016 were collected on the day of oocyte retrieval...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29681712/effectiveness-of-anti-mullerian-hormone-tailored-protocol-compared-to-conventional-protocol-in-women-undergoing-in-vitro-fertilization-a-randomized-controlled-trial
#5
Sumi Thomas, Mousumi Acharya, K Muthukumar, Achamma Chandy, Mohan S Kamath, T K Aleyamma
Background: Assessment of ovarian reserve before an in vitro fertilization cycle (IVF) is one among the many factors that predicts a successful cycle. Individualized protocol based on ovarian reserve is designed to optimize the pregnancy outcome without compromising the patient safety. Although authors have shown that anti-Mullerian hormone-tailored (AMH) protocols have reduced the treatment burden and improved pregnancy rates, a few others have questioned its efficacy. Aims: The aim of this study was to decide whether the AMH-tailored protocol or the conventional protocol better decides IVF outcomes...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29673662/the-influence-of-ovarian-hyperstimulation-drugs-on-morphometry-and-morphology-of-human-oocytes-in-icsi-program
#6
Fatemeh Taheri, Arezoo Alemzadeh Mehrizi, Mohammad Ali Khalili, Iman Halvaei
OBJECTIVE: To compare the influences of controlled ovarian hyperstimulation (COH) drugs using recombinant follicular stimulating hormone (rFSH) versus human menopausal gonadotropins (hMG) on morphometry and morphology of MII oocytes in ICSI cycles. MATERIALS AND METHODS: In this prospective study, 363 MII oocytes from 50 ICSI cycles with male factor infertility were evaluated. The patients were divided into two groups according to the protocols of COH: I- rFSH and II- hMG...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29667856/low-oxygen-environment-facilitates-embryo-availability-for-older-ovarian-responders-pors
#7
Mingzhao Li, Zhibin Li, Juanzi Shi
We aimed to investigate the different effects of low oxygen (5% O2 ) and atmospheric oxygen (20% O2 ) on in vitro fertilization for older poor ovarian responders (PORs). We selected 1080 older PORs who met two criteria: (i) advanced maternal age (≥40) and (ii) an abnormal ovarian reserve test. All the patients used the ultra-short term protocols with GnRH agonist and recombinant FSH for controlled ovarian hyperstimulation (COH). About 506 cycles were performed in the incubators with 5% O2 and 574 cycles were performed in the incubators with 20% O2 ...
April 18, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29658351/high-estrogen-exposure-may-not-be-detrimental-on-endometrial-receptivity-in-women-with-pcos
#8
Cigdem Abide Yayla, Enis Ozkaya, Gulay Beydilli Nacak, Ilhan Sanverdi, Belgin Devranoglu, Evrim Bostanci Ergen, Cetin Kilicci, Tayfun Kutlu
The study aimed to assess the effect of high estrogen exposure and coasting on cycle outcome in women at risk for developing ovarian hyperstimulation syndrome (OHSS). Retrospective case-control study was conducted to figure out the outcomes of GnRH antagonist cycles in which women were at risk to develop OHSS. Women who underwent coasting (n = 100) were compared with a control group of women who did not undergo coasting (n = 287). Effect of endometrial estrogen exposure was determined by calculating area under curve of temporal estrogen measurements (AUCEM) through the cycle...
April 14, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29655999/ovarian-hyperstimulation-syndrome-leading-to-ventriculoperitoneal-shunt-malfunction-case-report
#9
Amit Azriel, Benjamin Fleming, Uri P Dior, Samuel Moscovici, Yuval Sufaro, Mohammed Awad, Kate Drummond
Ventriculoperitoneal shunt (VPS) insertion is a common neurosurgical procedure for hydrocephalus. Unfortunately, VPS malfunction is not uncommon, with an estimated cumulative rate of 32% at 5 years. As flow through the shunt is influenced by the pressure gradient between the ventricles and the peritoneal cavity, malfunction may be caused by elevated intra-abdominal pressure. We present a rare patient with ascites following ovarian hyperstimulation syndrome (OHSS) leading to shunt malfunction. OHSS is a potentially life-threatening complication of controlled ovarian stimulation caused by the administration of exogenous gonadotropins...
April 11, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29621956/ovarian-hyperstimulation-reduces-vascular-endothelial-growth-factor-a-during-uterine-receptivity
#10
Kevin Danastas, Camilla M Whittington, Samson N Dowland, Valery Combes, Christopher R Murphy, Laura A Lindsay
The angiogenic factor vascular endothelial growth factor-A (VEGFA) plays a critical role during early pregnancy in many species including the rat, and any alterations in VEGFA levels can severely impact blastocyst implantation rates. The rat ovarian hyperstimulation (OH) model is useful in studying how the induction of superovulation affects VEGFA levels and endometrial receptivity to blastocyst implantation. The present study shows that the major isoform in the rat uterus, Vegf188 , is reduced at the time of receptivity in OH compared to normal pregnancy, whereas there is no change in Vegf164 and Vegf120 messenger RNA (mRNA)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29620984/controlled-ovarian-stimulation-for-in-vitro-fertilization
#11
Ruth Howie, Vanessa Kay
Controlled ovarian stimulation with gonadotrophins is an essential part of in-vitro fertilization treatment. The aim is to produce an optimum number of oocytes to maximize success in the safest possible way. Pituitary downregulation with a gonadotrophin-releasing hormone agonist and stimulation with recombinant follicle-stimulating hormone is used widely. However, there are many different protocols in use with little evidence to determine the optimum regimen. Markers of ovarian reserve and patient characteristics are used in an attempt to individualize treatment...
April 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29605409/effect-of-type-3-intramural-fibroids-on-in-vitro-fertilization-intracytoplasmic-sperm-injection-outcomes-a-retrospective-cohort-study
#12
Lei Yan, Qian Yu, Ya-Nan Zhang, Zizhen Guo, Zhongyuan Li, Jinlei Niu, Jinlong Ma
OBJECTIVE: To evaluate the influence of type 3 intramural fibroids on in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) outcomes. DESIGN: Retrospective cohort study. SETTING: University-based reproductive medicine center. PATIENT(S): All women undergoing IVF-ICSI from January 1, 2009, to December 31, 2016, in our unit. INTERVENTION(S): Each woman was matched with three separate control subjects of the same age (±1 year), number of cycles, type of infertility (primary or secondary), type of protocol used for controlled ovarian hyperstimulation (COH), and no uterine fibroids identified by transvaginal ultrasound...
March 28, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29605403/cycle-day-estrogen-level-and-lead-follicle-size-analysis-of-27-790-in-vitro-fertilization-cycles-to-determine-optimal-start-criteria-for-gonadotropin-releasing-hormone-antagonist
#13
Brianna M Lyttle Schumacher, Jennifer E Mersereau, Anne Z Steiner
OBJECTIVE: To determine the optimal criteria at which to start GnRH antagonists during controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). DESIGN: Retrospective clinical cohort. SETTING: IVF clinics. PATIENT(S): Women undergoing fresh autologous IVF using GnRH antagonist for ovulation suppression during COH. INTERVENTION(S): Measurement of lead follicle size, E2 level, and cycle day of stimulation on day of antagonist initiation...
March 28, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29576001/impact-of-metformin-on-ivf-outcomes-in-overweight-and-obese-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-controlled-trial
#14
Osama S Abdalmageed, Tarek A Farghaly, Ahmed A Abdelaleem, Ahmed E Abdelmagied, Mohammed K Ali, Ahmed M Abbas
OBJECTIVES: To evaluate the impact of metformin on in vitro fertilization (IVF) outcomes in overweight and obese women with polycystic ovary syndrome (PCOS). METHODS: This was a randomized double-blind placebo-controlled study ( ClinicalTrials.gov : NCT 02910817) carried out in a University IVF Center. The study included 102 overweight and obese women (body mass index [BMI] >24 kg/m2 ) with PCOS who underwent their first fresh autologous IVF-embryo transfer cycle and agreed to participate in the study...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29562260/towards-an-optimal-luteal-support-modality-in-agonist-triggered-cycles-a-randomized-clinical-trial
#15
E A Elgindy, H Sibai, M I Mostafa, A Gibreel, E Darwish, H Maghraby
STUDY QUESTION: In ICSI patients with high risk of ovarian hyperstimulation syndrome (OHSS), are antagonist cycles triggered by gonadotropin releasing hormone (GNRH) agonist with a specialized luteal support regimen associated with comparable ongoing pregnancy rate (OPR) and less OHSS than those triggered by hCG? SUMMARY ANSWER: In antagonist ICSI cycles, GnRH agonist triggering with a specialized luteal support regimen is associated with comparable OPR to those triggered by hCG but may be less likely to be associated with OHSS...
March 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29544639/the-ovarian-hyperstimulation-syndrome
#16
Zeev Blumenfeld
The ovarian hyperstimulation syndrome (OHSS) is an iatrogenic syndrome, which may, infrequently, become severe and evenly fatal. Until the last decade, the worldwide popularity of assisted reproductive technology (ART) and ovulation induction/controlled ovarian hyperstimulation employed in ART for either in vivo fertilization or in vitro fertilization, in the last two decades, has been accompanied by an increase in the cases of OHSS. In the last decade, the substitution of the human chorionic gonadotropin trigger with the gonadotropin-releasing hormone agonist trigger has decreased the incidence of this syndrome but did not eliminate it completely...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29538638/natural-conception-rates-in-couples-with-unexplained-or-mild-male-subfertility-scheduled-for-fertility-treatment-a-secondary-analysis-of-a-randomized-controlled-trial
#17
R van Eekelen, R I Tjon-Kon-Fat, P M M Bossuyt, N van Geloven, M J C Eijkemans, A J Bensdorp, F van der Veen, B W Mol, M van Wely
STUDY QUESTION: What is the natural conception rate over the course of 12 months in couples with unexplained or mild male subfertility who are scheduled for fertility treatment and have a predicted unfavourable prognosis for natural conception? SUMMARY ANSWER: The natural conception rate over the course of 12 months in couples who were allocated to treatment was estimated to be 24.5% (95% CI: 20-29%). WHAT IS KNOWN ALREADY: After starting treatment, couples often perceive unsuccessful cycles as evidence of definitive failure even though they are still able to conceive naturally in between and after treatment...
March 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29527850/use-of-aromatase-inhibitors-in-ivf-for-fertility-preservation-of-non-breast-cancer-patients-a-case-series
#18
Avi Ben-Haroush, Irit Ben-Aharon, Yechezkel Lande, Benjamin Fisch
BACKGROUND: Controlled ovarian hyperstimulation (COH) followed by oocyte retrieval is a leading option for fertility preservation before chemotherapy, yet this procedure causes excessive serum levels of estradiol (E2), which are often detrimental for cancer patients. Aromatase inhibitors are often used in breast cancer patients during COH to prevent elevated levels of E2. OBJECTIVES: To describe our experience with COH for oocyte cryopreservation in non-breast cancer patients using aromatase inhibitors...
March 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29526845/polymorphism-fshr-29g-a-as-a-genetic-agent-together-with-esri-xbaig-a-in-women-with-poor-response-to-controlled-ovarian-hyperstimulation
#19
Tannaz Zamaniara, Robabeh Taheripanah, Sayyed Mohammad Hossein Ghaderian, Elnaz Zamaniara, Sara Sadat Afjeh Aghabozorgi
BACKGROUND: One of the major problems in IVF is the poor response of the ovary to gonadotropins. ESRI and FSHR are two effective genes on controlled ovarian hyperstimulation (COH). OBJECTIVES: Evaluating the correlation of alleles and genotypes of polymorphism (-29G/A) located in the FSH receptor gene and polymorphism (XbaI G/A) located in Estrogen receptor genes with the ovary's response would help to anticipate the results of ovulation in IVF cycles. METHODS: In the present study, two hundred (200) blood samples were taken from infertile women aged 20 to 39 who were under IVF therapy...
January 19, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29507026/multiorgan-failure-associated-with-severe-ovarian-hyperstimulation-syndrome-due-to-inadequate-protocol-optimisation-a-rare-but-avoidable-complication
#20
Lorraine Sheena Kasaven, Anastasia Goumenou, Kenneth Adegoke
Ovarian hyperstimulation syndrome (OHSS) is a well-recognised iatrogenic complication following controlled ovarian stimulation (COS). Mild to moderate cases are mostly managed conservatively. Severe cases of OHSS can be potentially fatal. For this reason, UK clinics providing licensed fertility treatment are obliged to follow Human Fertilisation and Embryology Authority guidelines for reporting severe incidents. We present an unusually severe complication of OHSS resulting in significant morbidity. A nulligravida woman aged 25, with a 4-year history of subfertility and multiple risk factors for the development of OHSS, underwent COS...
March 5, 2018: BMJ Case Reports
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