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Burçin Şanlidag, Ceyhun Balkan, Nerin Bahçeciler
Kawasaki Disease (KD) is a systemic autoimmune vasculitis that affects small and medium sized vessels. Main complication of Kawasaki Disease is coronary artery aneurism, which has higher risk in case of delayed diagnosis and treatment. Although, complete and incomplete KD cases in different types of immune deficiency diseases have been presented up to date, clinical course of KD in patients with hypogammaglobulinemia (HG) has not been reported. Herein, a case diagnosed as incomplete KD in a child with transient HG of infancy has been reported...
April 1, 2018: Archivos Argentinos de Pediatría
Ali Zamani, Huahao Fan, Guangxiang Luo
Hepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy of the liver. A more thorough understanding of HCC pathogenesis will provide novel targets for development of cancer drugs to effectively treat HCC. To further this goal, we carried out a proteomic profiling of HCC cell lines Huh-7.4 and Huh-7.5. These two cell lines were derived from subgenomic HCV RNA-replicating Huh-7 cells upon clearance of HCV RNA by antiviral drug treatment. Initially, the tumorigenicity of each cell line was determined and compared in parallel in the same immunedeficient mice...
November 10, 2017: Oncotarget
Kenichiro Kasahara, Yachiyo Fukunaga, Saori Igura, Rie Andoh, Tsubasa Saito, Isamu Suzuki, Hiroyuki Kanemitsu, Daisuke Suzuki, Ken Goto, Daichi Nakamura, Masahiro Mochizuki, Masahiko Yasuda, Ryo Inoue, Kazutoshi Tamura, Mariko Nagatani
To obtain background data of NOD/Shi-scid IL-2Rγnull (NOG) mice, severely immunedeficient mice, a total of 120 animals were examined at 7, 26 and 52 weeks-old (20 mice/sex/group). The survival rate at 52 weeks-old was 95% (19/20) in both sexes. Clinically, circling behavior in one direction along the cage wall was observed in males after 8 weeks and females after 47 weeks-old, and hunchback position was found in males after 32 weeks-old. Hematologically, lymphocyte count markedly decreased at all ages, while white blood cell count increased in several mice at 52 weeks-old...
2017: Journal of Toxicological Sciences
Shields Callahan, Randie H Kim, Nooshin Brinster, Jo-Ann Latkowski
We report an HIV-negative, 55-year-old manwith recurrent Kaposi's sarcoma (KS) of the lowerextremities, who does not fit into any of thefour previously described variants of KS: classicKS, AIDS-related KS, iatrogenic KS, and AfricanendemicKS. There are reports in the literature ofchildhood-onset KS, which is thought to be dueto an inherited immune deficiency that confers ahigher susceptibility to human Herpesvirus-8 (HHV-8), which is the virus that is known to cause KS. Ourpatient may be affected with an inherited immunedeficiency that has predisposed him to KS, and thismutation also may account for his prostate andbladder cancer...
December 15, 2016: Dermatology Online Journal
Luisa Lorenzi, Silvia Lonardi, Murad H M Essatari, Vilma Pellegrini, Simona Fisogni, Anna Gazzola, Claudio Agostinelli, William Vermi, Giuseppe Rossi, Giovannino Massarelli, Stefano A Pileri, Fabio Facchetti
Germinotropic lymphoproliferative disorders were previously described as localized disorders associated with coinfection by human herpes virus 8 and Epstein-Barr virus and characterized by good clinical outcome. We report the clinical, morphological, phenotypical, and molecular features of three cases of a hitherto unreported variant of Epstein-Barr virus (EBV)-positive, human herpes virus 8 (HHV8)-negative large B cell lymphoma with exclusive intrafollicular localization. All cases occurred in elderly individuals (63, 77, and 65 years old; one male, two females) without obvious immunedeficiency, who presented with high stage disease...
April 2016: Virchows Archiv: An International Journal of Pathology
Jaemin Jo, Sang Taek Heo, Jae Wang Kim, Jinseok Kim, Jung Re Yu
Although, erythema nodosum is a common skin manifestation associated with syphilis, nodular vasculitis is a rare feature. Here, we describe a case of a 22-year-old, human immunedeficiency virus negative, non-immunocompromised man who developed recurrent oral and scrotal ulcers with nodular lesions of the lower extremitie. Behçet's disease was initially suspected, however, his serologic test for syphilis was positive, and he was thus diagnosed with secondary syphilis, with a skin biopsy showing nodular vasculitis...
December 2013: Infection & Chemotherapy
Ka Yu Yeung, Adam Dickinson, Jacqueline F Donoghue, Galina Polekhina, Stefan J White, Dimitris K Grammatopoulos, Matthew McKenzie, Terrance G Johns, Justin C St John
BACKGROUND: Mitochondrial DNA (mtDNA) encodes key proteins of the electron transfer chain (ETC), which produces ATP through oxidative phosphorylation (OXPHOS) and is essential for cells to perform specialised functions. Tumor-initiating cells use aerobic glycolysis, a combination of glycolysis and low levels of OXPHOS, to promote rapid cell proliferation and tumor growth. Glioblastoma multiforme (GBM) is an aggressively malignant brain tumor and mitochondria have been proposed to play a vital role in GBM tumorigenesis...
2014: Acta Neuropathologica Communications
K R Engelhardt, B Grimbacher, T Niehues
Primary (inborn) immunodeficiency is caused by gene defects that impact both the innate and the adaptive immune system. Individuals with an immunedeficiency primarily come to medical attention with recurrent infections. Most diagnoses are first made in childhood and include cellular immunodeficiency, defects of phagocyte function and other primary immunodeficiencies. Antibody deficiencies, particularly common variable immunodeficiency (CVID) and complement defects may, however, not become manifested until adulthood...
September 2013: Zeitschrift Für Rheumatologie
Quan-Yu Cai, Ping Yu, Cynthia Besch-Williford, Charles J Smith, Gary L Sieckman, Timothy J Hoffman, Lixin Ma
BACKGROUND: Development of high affinity and specificity molecular imaging probes that increase accuracy for early detection of lymph node (LN) metastases is important for improving survivorship in prostate cancer. We evaluated the specificity, sensitivity, and accuracy of fluorescence-labeled bombesin (BBN) peptides to detect LN and systematic metastases in orthotopic mouse models bearing gastrin releasing peptide receptor (GRPR)-positive human prostate cancer. METHODS: PC-3 cells were orthotopically implanted in severe combined immunedeficient or thymic nude (nu/nu) male mice...
June 2013: Prostate
C Thammavong, P Paboriboune, B Bouchard, A Harimanana, F-X Babin, P Phimmasone, J-L Berland, Y Buisson
BACKGROUND: Laos has a high prevalence of tuberculosis (TB) and a slowly increasing prevalence of human immunodeficiency virus/acquired immunedeficiency syndrome (HIV/AIDS). Sputum smear microscopy is the only method currently available for routine screening of pulmonary TB, although it only detects one in three cases among persons living with HIV (PLWH). Bleach treatment of sputum samples (bleach method) has been shown to significantly improve the sensitivity of the test; however, its effectiveness in PLWH remains to be determined in Laos...
October 2011: International Journal of Tuberculosis and Lung Disease
I Tsuge, Y Kondo, Y Nakajima, N Nakagawa, K Imai, S Nonoyama, K Oshima, O Ohara, M Hatanaka, E Kitano, H Kitamura, A Urisu
Many immunedeficiency syndromes are associated with autoimmune disorders. We here report on a girl with a systemic lupus erythematosus-like disease who suffered from both hyperimmunoglobulin M syndrome (HIGMS) and C1q deficiency. Despite severe central nervous system-lupus like disease, probably due to C1q deficiency, kidney function was relatively spared. IgM autoantibody might play a protective role against lupus-glomerulonephritis.
July 2010: Clinical and Experimental Rheumatology
Ketao Jin, Lisong Teng, Yanping Shen, Kuifeng He, Zhenzhen Xu, Guangliang Li
Mouse cancer models have consistently been used to qualify new anticancer drugs in the development of human clinical trials. Rodent tumour models currently being used and which include transgenic tumour models, and those generated by planting human tumour cell lines subcutaneously in immunodeficient mice, do not sufficiently represent clinical cancer characteristics, especially with regard to metastasis and drug sensitivity. The increasingly used patient-derived human tumour tissue (PDTT) xenografts models implanted subcutaneously or in subrenal capsule in immunodeficient mice, such as athymic nude mice or severe combined immunedeficient (SCID) mice, may provide a more accurate reflection of human tumour biological characteristics than tumour cell lines...
July 2010: Clinical & Translational Oncology
Yechiel Schlesinger, Efrat Ben-Shalom, David P Raveh, Amos M Yinnon, Hagit Miskin, Bernard Rudensky
Vibrio vulnificus is a Gram-negative bacterium that may cause severe skin and systemic infection after exposure of open wounds to contaminated water, especially in patients with underlying disease such as immune-deficiency, iron overload or end stage liver or renal disease. The V. vulnificus infection has been reported in Israel almost exclusively after exposure to Tilapia fish cultivated in fresh water fish ponds in northern Israel. The authors report the first case of V. vulnificus infection acquired in a nature reserve in southeastern Israel, with no connection to fish handling...
November 2009: Harefuah
Dong-Min Li, Ning Wang
No abstract text is available yet for this article.
July 2009: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Masako Nakahara, Kumiko Saeki, Naoko Nakamura, Satoko Matsuyama, Yoshiko Yogiashi, Kazuki Yasuda, Yasushi Kondo, Akira Yuo
We previously reported that cynomolgus monkey embryonic stem (ES) cells could be maintained under a feeder-free condition without using recombinant cytokines if sizes and numbers of ES colonies were kept within an appropriate range. Here we show that this finding is also true with human ES cells (hESCs). The two lines of hESCs, khES-1 and khES-3, were appropriately maintained in the absence of feeder layers or exogenous cytokines such as fibroblast growth factors, Noggin, transforming growth factor beta, and Activin by closely controlling the size and number of hESC colonies...
March 2009: Cloning and Stem Cells
A D Harries, M Boxshall, S Phiri, J van Gorkom, R Zachariah, S B Squire, S D Makombe, J Kwanjana, M Gondwett
Human immunodeficiency virus (HIV)/acquired immunedeficiency syndrome (AIDS) and tuberculosis (TB) cause an immense burden of disease in sub-Saharan Africa. A large amount of knowledge has been gathered in the last 15 years about the negative impact that HIV has on TB control, both at a programme level and at the level of the individual patient. Equally, interventions that are known to benefit patients have been tested and piloted, and these form important components of international TB-HIV guidelines, a TB-HIV strategic framework and an interim policy on TB-HIV coordination...
December 2006: International Journal of Tuberculosis and Lung Disease
Iradj Amirlak, Bardia Amirlak
Haemolytic uraemic syndrome (HUS) is the most common cause of acute renal failure in children. The syndrome is defined by triad of microangiopathic haemolytic anaemia, thrombocytopenia and acute renal failure (ARF). Incomplete HUS is ARF with either haemolytic anaemia or thrombocytopenia. HUS is classified into two subgroups. Typical HUS usually occurs after a prodrome of diarrhoea (D+HUS), and atypical (sporadic) HUS (aHUS), which is not associated with diarrhoea (D-HUS). The majority of D+HUS worldwide is caused by Shiga toxin-producing Esherichia coli (STEC), type O157:H7, transmitted to humans via different vehicles...
June 2006: Nephrology
Uwe Nicolay, Peter Kiessling, Melvin Berger, Sudhir Gupta, Leman Yel, Chaim M Roifman, Ann Gardulf, Florian Eichmann, Stefan Haag, Cordula Massion, Hans D Ochs
The lifelong IgG replacement therapy for patients with primary immunedeficiencies (PIDD) may be provided by intravenous (IVIG) or by subcutaneous IgG (SCIG) infusions. We investigated the impact of weekly SCIG self-infusions at home on the health-related quality of life, treatment satisfaction, and preferences in patients treated with IVIG at the hospital/doctor's office (Group A) or at home (Group B) before the study started. Forty-four adult North American PIDD patients were included in the study, 28 patients in Group A and 16 in Group B...
January 2006: Journal of Clinical Immunology
Hong Li, Zhe Wang, Wei-guo Cui, Yan Liang, Tian-yi Xin, Jie Li
OBJECTIVE: To study on the compliance antiretroviral(ARV) drugs and interrelated factors of HIV/AIDS patients undertaking highly active antiretroviral therapy(HAART) to improve clinical treatment. METHODS: 3 counties in Henan province were selected including 2 counties from China Cares Program points and one county where HIV/AIDS was serious. All cases studied had already received antiretroviral therapy (ART) for 2-12 months. Several indicators through questionnaire were studied including drug adherence, side effect, symptoms status before and after treatment and ART measures etc...
July 2005: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Bernardino Geraldo Alves Souto
Analyzing social, behavior and morbidity data of serum-positive individuals to the test anti-HIV in a Brazilian town city, they were detected: diffusion of the virus of the human immunedeficiency by via heterosexual, in epidemic profile similar to the HIV/AIDS appearance time in the world economically underdeveloped; change of sexual behavior from people when they notice they were involved with HIV; importance of the access to the attendance in the reduction of the morbidity of infected people with HIV and for the transmissibility of this disease in the community...
May 2004: Revista Cubana de Medicina Tropical
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