Saurav Kumar Jha, Gabriele De Rubis, Shankar Raj Devkota, Yali Zhang, Radhika Adhikari, Laxmi Akhileshwar Jha, Kunal Bhattacharya, Samir Mehndiratta, Gaurav Gupta, Sachin Kumar Singh, Nisha Panth, Kamal Dua, Philip M Hansbro, Keshav Raj Paudel
Lung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80-85% and SCLC accounts for 10-15% of cases. NSCLC subtypes include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Smoking, second-hand smoke, radon gas, asbestos, and other pollutants, genetic predisposition, and COPD are lung cancer risk factors. On the other hand, stresses such as DNA damage, telomere shortening, and oncogene activation cause a prolonged cell cycle halt, known as senescence...
April 26, 2024: Ageing Research Reviews