Xiaotong Xia, Nianxu Huang, Boxia Li, Yan Li, Lang Zou, Dongdong Yuan, Banghua Huang, Yufei Bei, Yuxin Liu, Jinglan Fu, Tingting Wu, Wenjun Chen, Shaojun Jiang, Meina Lv, Jinhua Zhang
PURPOSE: The purpose of this paper is to study the correlation between demographic and clinical factors and warfarin dose of patients in Chinese Han population taking warfarin and study gene polymorphisms impact of related gene loci (CYP2C9*3, VKORC1-1639G > A) on warfarin doses, to establish a model to predict initial standard dose and maintenance dose based on CYP2C9*3, VKORC1-1639G > A genotype. METHODS: The study collects the data of patients in our hospital and other subcenters which incorporates 2160 patients to establish the initial dose model and 1698 patients for the stable dose model, and sequences 26 multigene sites in 451 patients...
August 28, 2021: European Journal of Clinical Pharmacology