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https://www.readbyqxmd.com/read/28961851/comprehensive-genomic-profiles-of-metastatic-and-relapsed-salivary-gland-carcinomas-are-associated-with-tumor-type-and-reveal-new-routes-to-targeted-therapies
#1
J S Ross, L M Gay, K Wang, J-A Vergilio, J Suh, S Ramkissoon, H Somerset, J M Johnson, J Russell, S Ali, A B Schrock, D Fabrizio, G Frampton, V Miller, P J Stephens, J A Elvin, D W Bowles
Background: Relapsed/metastatic salivary gland carcinomas (SGCs) have a wide diversity of histologic subtypes associated with variable clinical aggressiveness and response to local and systemic therapies. We queried whether comprehensive genomic profiling could define the tumor subtypes and uncover clinically relevant genomic alterations, revealing new routes to targeted therapies for patients with relapsed and metastatic disease. Patients and methods: From a series of 85 686 clinical cases, DNA was extracted from 40 µm of formalin-fixed paraffin embedded (FFPE) sections for 623 consecutive SGC...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28952840/quantifying-cricket-fast-bowling-skill
#2
Simon A Feros, Warren B Young, Brendan J O'Brien
OBJECTIVES: To evaluate the current evidence regarding the quantification of cricket fast bowling skill. METHODS: Studies that assessed fast bowling skill (bowling speed and accuracy) were identified from searches in SPORTDiscus (EBSCO) in June 2017. The reference lists of identified papers were also examined for relevant investigations. RESULTS: Sixteen papers matched the inclusion criteria, and discrepancies in assessment procedures were evident...
September 27, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28862782/mycorrhizal-fungi-enhance-plant-nutrient-acquisition-and-modulate-nitrogen-loss-with-variable-water-regimes
#3
Timothy M Bowles, Louise E Jackson, Timothy R Cavagnaro
Climate change will alter both the amount and pattern of precipitation and soil water availability, which will directly affect plant growth and nutrient acquisition, and potentially, ecosystem functions like nutrient cycling and losses as well. Given their role in facilitating plant nutrient acquisition and water stress resistance, arbuscular mycorrhizal (AM) fungi may modulate the effects of changing water availability on plants and ecosystem functions. The well-characterized mycorrhizal tomato (Solanum lycopersicum L...
September 1, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28834373/adhd-medication-dietary-patterns-physical-activity-and-bmi-in-children-a-longitudinal-analysis-of-the-ecls-k-study
#4
April Bowling, Kirsten Davison, Sebastien Haneuse, William Beardslee, Daniel P Miller
OBJECTIVE: This study examined relationships between attention-deficit/hyperactivity disorder (ADHD), stimulant use, and BMI change in a nationally representative cohort of children as well as differences in diet and physical activity that may mediate associations between stimulant use and BMI change. METHODS: By using the Early Childhood Longitudinal Study-Kindergarten Cohort 1998-1999 (N = 8,250), we modeled BMI and z score change by ADHD and stimulant start time, examined the odds of unhealthy diet and physical activity predicted by ADHD and stimulant use, and performed mediation analysis assessing indirect effects of health behaviors...
August 20, 2017: Obesity
https://www.readbyqxmd.com/read/28599031/foreign-language-short-course-special-operations-clinical-research-fundamentals
#5
REVIEW
Kate Rocklein-Kemplin, F Bowling
When we do not know a language, we are at the mercy of an interpreter. The same is true for research: Special Operations Forces (SOF) clinicians not actively involved in research initiatives may rely on scientific interpreters, so it is important to speak some of the language personally. For any clinician, using evidence in practice requires a working knowledge of how that evidence was generated from research, which requires an understanding of research science language. Here we review common basics of research science to reinforce concepts and elements of experimental and nonexperimental research...
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28508987/transmission-of-h6n2-wild-bird-origin-influenza-a-virus-among-multiple-bird-species-in-a-stacked-cage-setting
#6
J Jeffrey Root, Susan A Shriner, Jeremy W Ellis, Kaci K VanDalen, Alan B Franklin
Live bird markets are common in certain regions of the U.S. and in other regions of the world. We experimentally tested the ability of a wild bird influenza A virus to transmit from index animals to naïve animals at varying animal densities in stacked cages in a simulated live bird market. Two and six mallards, five and twelve quail, and six and nine pheasants were used in the low-density and high-density stacks of cages, respectively. Transmission did not occur in the high-density stack of cages likely due to the short duration and relatively low levels of shedding, a dominance of oral shedding, and the lack of transmission to other mallards in the index cage...
May 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28508942/-conservative-and-surgical-ileus-treatment
#7
H Listle, C Gutt
The diagnosis ileus is one of the most common indications for an emergency laparotomy. In 70% of the cases, the small intestine is affected, and in 30% it is the colorectum. While stuck hernias are a major cause in developing countries, the most common causes in western countries are postoperative adhesions that lead to an acute bowl obstruction. The timeframe for treatment of a complete mechanical obstruction is short as acute ischemia can lead to necrosis with bowl perforation within 6 h. The perioperative lethality for an emergency laparotomy due to an ileus ranges from 5-15%...
July 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28437634/convolutional-neural-network-regression-for-short-axis-left-ventricle-segmentation-in-cardiac-cine-mr-sequences
#8
Li Kuo Tan, Yih Miin Liew, Einly Lim, Robert A McLaughlin
Automated left ventricular (LV) segmentation is crucial for efficient quantification of cardiac function and morphology to aid subsequent management of cardiac pathologies. In this paper, we parameterize the complete (all short axis slices and phases) LV segmentation task in terms of the radial distances between the LV centerpoint and the endo- and epicardial contours in polar space. We then utilize convolutional neural network regression to infer these parameters. Utilizing parameter regression, as opposed to conventional pixel classification, allows the network to inherently reflect domain-specific physical constraints...
April 12, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28294240/pegylation-corannulene-enhances-response-of-stress-through-promoting-neurogenesis
#9
Xinyu Li, Dandan Sun, Xu Li, Dashuai Zhu, Zhenzhen Jia, Jiajia Jiao, Kai Wang, Deling Kong, Xin Zhao, Lin Xu, Qiang Zhao, Dongyan Chen, Xizeng Feng
Carbon nanomaterials have been used to treat neurodegenerative diseases and neural disorders due to their diverse molecular structures. Corannulene is a three-dimensional π-bowl carbon nanomaterial that is different from planar PAHs, fullerenes and carbon nanotubes, but little is known about its biological functions. Herein, corannulene was functionalized with mPEG-DESP to prepare PEGylation corannulene nanoparticles (PEGylation CoNps). The synthesized PEGylation CoNps shows enhanced solubility and reduced aggregation when compared corannulene...
March 15, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28282033/pi3k%C3%AE-and-pi3k%C3%AE-isoforms-have-distinct-functions-in-regulating-pro-tumoural-signalling-in-the-multiple-myeloma-microenvironment
#10
R E Piddock, N Loughran, C R Marlein, S D Robinson, D R Edwards, S Yu, G E Pillinger, Z Zhou, L Zaitseva, M J Auger, S A Rushworth, K M Bowles
Phosphoinositide-3-kinase and protein kinase B (PI3K-AKT) is upregulated in multiple myeloma (MM). Using a combination of short hairpin RNA (shRNA) lentivirus-mediated knockdown and pharmacologic isoform-specific inhibition we investigated the role of the PI3K p110γ (PI3Kγ) subunit in regulating MM proliferation and bone marrow microenvironment-induced MM interactions. We compared this with inhibition of the PI3K p110δ (PI3kδ) subunit and with combined PI3kδ/γ dual inhibition. We found that MM cell adhesion and migration were PI3Kγ-specific functions, with PI3kδ inhibition having no effect in MM adhesion or migration assays...
March 10, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28215637/polyglycolic-acid-sheet-attached-with-fibrin-glue-can-facilitate-faster-epithelialization-of-the-mastoid-cavity-after-canal-wall-down-tympanoplasty
#11
Taisuke Kobayashi, Kiyofumi Gyo, Masahiro Komori, Masamitsu Hyodo
OBJECTIVE: This study retrospectively investigated whether polyglycolic acid (PGA) sheet attached to the bone surface using fibrin glue facilitate faster epithelialization of the mastoid bowl after canal wall-down (CWD) tympanoplasty compared to a simple dressing using poly-N-acetyl-glucosamine (Kichin) sheet. MATERIALS AND METHODS: After completion of the CWD tympanoplasty, PGA sheet (n=16, PGA group) with fibrin glue or Kichin sheet (n=38, Kichin group) were placed on the bone surface of the mastoid bowl...
December 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28031787/lac-1-and-lag-1-with-ras-1-affect-aging-and-the-biological-clock-in-neurospora-crassa
#12
John K Brunson, James Griffith, Daneisha Bowles, Mary E Case, Jonathan Arnold
Using an automated cell counting technique developed previously (Case et al., Ecology and Evolution 2014; 4: 3494), we explore the lifespan effects of lac-1, a ceramide synthase gene paralogous to lag-1 in Neurospora crassa in conjunction with the band bd (ras-1) gene. We find that the replicative lifespan of a lac-1(KO)bd double mutants is short, about one race tube cycle, and this double mutant lacks a strong ~21-hr clock cycle as shown by race tube and fluorometer analysis of fluorescent strains including lac-1(KO) ...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27547440/association-of-age-with-health-related-quality-of-life-in-a-cohort-of-patients-with-systemic-lupus-erythematosus-the-georgians-organized-against-lupus-study
#13
Laura Plantinga, S Sam Lim, C Barrett Bowling, Cristina Drenkard
OBJECTIVE: To examine whether older age was associated with lower health-related quality of life (HRQOL) among patients with systemic lupus erythematosus (SLE) and whether differential disease-related damage and activity explained these associations. METHODS: We used cross-sectional data on 684 patients with SLE aged ≥20 years from the Georgians Organized Against Lupus cohort to estimate the associations between age (categorised as 20-39, 40-59 and ≥60 years) and HRQOL (Short Form-12 norm-based domain and physical component summary (PCS) and mental component summary (MCS) scores), using multivariable linear regression...
2016: Lupus Science & Medicine
https://www.readbyqxmd.com/read/27309593/latissimus-dorsi-and-teres-major-tendon-avulsions-in-cricketers-a-case-series-and-literature-review
#14
Krishant S Naidu, Trefor James, Andrew H Rotstein, Simon M Balster, Gregory A Hoy
INTRODUCTION: Acute latissimus dorsi tendon injuries are uncommon, having not previously been described in cricketers. The leg spinner's stock ball bowling technique and the fast bowler's back-of-the-hand slow ball, which is used much more widely in T20 cricket, produce a significant eccentric contraction load on the latissimus dorsi muscle. METHODOLOGY: A retrospective review of a case series of acute latissimus dorsi tendon injuries in 3 elite cricketers (2 fast bowlers and a leg-spin bowler)...
May 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/27299123/an-isolated-displaced-fracture-of-the-coracoid-process-treated-with-open-reduction-and-internal-fixation-a-case-report-and-review-of-literature
#15
Shreedhar Archik, Saurav Narayan Nanda, Sanjay Tripathi, Ashlesh Choudhari, Harshada Rajadhyaksha
INTRODUCTION: Isolated coracoid fractures are rare and few scattered cases are reported in literature. Coracoid fractures can be missed and the treatment for coracoid process fractures is still controversial. The case presented here is of an isolated coracoid process fracture which was treated surgically. CASE REPORT: A 15-years old male presented after 4 days of injury complaining of persistent pain in the right shoulder following a jerk during bowling. Physical examination revealed tenderness in the left shoulder...
January 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/27281196/fission-and-reconfiguration-of-bilobate-comets-as-revealed-by-67p-churyumov-gerasimenko
#16
Masatoshi Hirabayashi, Daniel J Scheeres, Steven R Chesley, Simone Marchi, Jay W McMahon, Jordan Steckloff, Stefano Mottola, Shantanu P Naidu, Timothy Bowling
The solid, central part of a comet--its nucleus--is subject to destructive processes, which cause nuclei to split at a rate of about 0.01 per year per comet. These destructive events are due to a range of possible thermophysical effects; however, the geophysical expressions of these effects are unknown. Separately, over two-thirds of comet nuclei that have been imaged at high resolution show bilobate shapes, including the nucleus of comet 67P/Churyumov-Gerasimenko (67P), visited by the Rosetta spacecraft. Analysis of the Rosetta observations suggests that 67P's components were brought together at low speed after their separate formation...
June 16, 2016: Nature
https://www.readbyqxmd.com/read/27248509/a-review-of-the-internal-and-external-physiological-demands-associated-with-batting-in-cricket
#17
REVIEW
Aaron T Scanlan, Daniel M Berkelmans, William M Vickery, Crystal O Kean
Cricket is a popular international team sport with various game formats ranging from long-duration multiday tests to short-duration Twenty20 game play. The role of batsmen is critical to all game formats, with differing physiological demands imposed during each format. Investigation of the physiological demands imposed during cricket batting has historically been neglected, with much of the research focusing on bowling responses and batting technique. A greater understanding of the physiological demands of the batting role in cricket is required to assist strength and conditioning professionals and coaches with the design of training plans, recovery protocols, and player-management strategies...
November 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27189183/controlling-electronic-effects-and-intermolecular-packing-in-contorted-polyaromatic-hydrocarbons-c-pahs-towards-high-mobility-field-effect-transistors
#18
Kalishankar Bhattacharyya, Titas Kumar Mukhopadhyay, Ayan Datta
We have investigated the electronic and charge transport properties of two regioisomeric contorted polyaromatic hydrocarbons at the molecular level as well as in the crystalline state. Electron and hole transport is studied on the basis of an incoherent charge hopping model through DFT calculations. For trifluro-dibenzoperylene (CF3-DBP, ), which crystallizes as a herringbone network, the computed drift hole and electron mobilities are 0.234 and 0.008 cm(2) V(-1) S(-1), respectively. The greater hole mobility in the DBP crystal (μh/μe = 29) can be rationalized by its lower hole reorganization energy and higher hole transfer integral simultaneously...
June 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27166208/short-term-risk-of-serious-fall-injuries-in-older-adults-initiating-and-intensifying-treatment-with-antihypertensive-medication
#19
Daichi Shimbo, C Barrett Bowling, Emily B Levitan, Luqin Deng, John J Sim, Lei Huang, Kristi Reynolds, Paul Muntner
BACKGROUND: Antihypertensive medication use has been associated with an increased risk of falls in some but not all studies. Few data are available on the short-term risk of falls after antihypertensive medication initiation and intensification. METHODS AND RESULTS: We examined the association between initiating and intensifying antihypertensive medication and serious fall injuries in a case-crossover study of 90 127 Medicare beneficiaries who were ≥65 years old and had a serious fall injury between July 1, 2007, and December 31, 2012, based on emergency department and inpatient claims...
May 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27149993/calming-and-focusing-students-perceptions-of-short-classroom-strategies-for-fostering-presence
#20
Debra VanKuiken, Jennifer Bradley, Barbara Harland, Margaret O'Brien King
PURPOSE: Presence is the essence of professional nursing in the nurse-patient connection. Nursing students have little exposure to strategies fostering presence. This pilot study explored students' perceptions of strategies to encourage presence in the classroom. DESIGN: A three-question survey was distributed to students in the last week of classes. Faculty not teaching that course administered the survey. METHOD: Four faculty used strategies aimed at encouraging presence...
May 5, 2016: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
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