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Fetal mri

Beth Kline-Fath, Monica S Arroyo, Maria A Calvo-Garcia, Paul S Horn, Cameron Thomas
PURPOSE: To evaluate the effects of progressive hydrocephalus on the developing brain in a cohort of fetuses diagnosed with congenital aqueduct stenosis (CAS) by comparing prenatal MRI and postnatal imaging. METHODS: This IRB approved single center retrospective review of prenatally diagnosed children with CAS interrogated changes in the brain between prenatal and postnatal imaging and analyzed statistics utilizing SAS ® software package version 9.3. RESULTS: Thirty fetuses imaged at a mean gestational age of 26 weeks had aqueduct obstruction confirmed by postnatal imaging...
June 21, 2018: Prenatal Diagnosis
Zequn Liu, Jin Han, Fang Fu, H S Liu, Qiu-Ming He, Wei Zhong, Hongying Wang, Xin Yang, Dongzhi Li, Can Liao
OBJECTIVE: The aim of this study was to make an accurate diagnosis of pyriform sinus fistula (PSF) for prenatal diagnosis. STUDY DESIGN: Medical records were reviewed for all 35 pyriform sinus fistula patients presenting between 2011 and 2017. Ultrasonography (US), fetal magnetic resonance imaging (MRI) and karyotyping were offered during gestation, while computer tomography (CT) and barium esophagography were performed after birth. RESULTS: Patients included 21 males (60%) and 14 females (40%) with a sex ratio of 1...
June 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Chressen Catharina Remus, Fabian Kording, Petra Arck, Emilia Solano, Jan Sedlacik, Gerhard Adam, Kurt Hecher, Nils Daniel Forkert
OBJECTIVES: Stress during pregnancy is known to have negative effects on fetal outcome. The purpose of this exploratory study was to examine placental perfusion alterations after stress challenge during pregnancy in a mouse model. MATERIAL AND METHODS: Seven Tesla MRI was performed on pregnant mice at embrionic day (ED) 14.5 and 16.5. Twenty dams were exposed to an established acoustic stress challenge model while twenty non-exposed dams served as controls. Placental perfusion was analyzed in dynamic contrast-enhanced (DCE) MRI using the steepest slope model...
May 2018: Placenta
Emily Olivares, Justin Castellow, Jamil Khan, Susanne Grasso, Victor Fong
Teratomas are rare congenital tumors typically comprising all 3 germ cell layers. Cervical teratomas arise in the neck and represent a minority of all teratomas. These are associated with high morbidity and mortality because of their propensity to cause airway obstruction. Demonstration on prenatal magnetic resonance imaging is uncommon, especially for a tumor of this size. Fetuses diagnosed with large neck masses are managed through cesarean section with the ex utero intrapartum treatment procedure to secure the airway, such as in our case of a large cervical teratoma in the female fetus of a 30-year-old mother who went into preterm labor...
April 2018: Radiology Case Reports
L Ghesquière, V Houfflin-Debarge, P Verpillat, T Fourquet, S Joriot, C Coulon, P Vaast, C Garabedian
INTRODUCTION: Intrauterine transfusion (IUT) has changed fetal anemia prognosis. However, long-term neurodevelopmental outcome is altered in 5% of children. Our objective was to study the contribution of fetal MRI to diagnosis brain lesions in case of fetal anemia. MATERIAL AND METHODS: Retrospective monocentric descriptive study from 2005 to 2016, including all patients followed for fetal anemia requiring IUT. The indications for MRI were: hydrops fetalis and / or hemoglobin <5 g / dL and / or more than 3 IUTs and / or acute severe anemia and / or ultrasound abnormality...
June 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Wonsang You, Feng Xu, Catherine Limperopoulos
Functional MRI studies have started the hemodynamic responses of the placenta and fetal brain using maternal hyperoxia. While most studies have focused on analyzing the changes in magnitude of fMRI signals, few studies have analyzed the latency and duration of responses to hyperoxia. This paper proposes a linear convolution model of fetal circulation where a chain of responses to maternal hyperoxia are produced in the placenta and fetal brain. Specifically, an impulse response to hyperoxia was modeled as the hemodynamic response function (HRF) which consists of multiple gamma functions...
April 2018: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
G Shapira-Zaltsberg, D Grynspan, M V Quintana, P C Dominguez, D Reddy, J H Davila, E Miller
AIM: To investigate if magnetic resonance imaging (MRI) features of the placenta are different in fetuses with and without central nervous system (CNS) abnormalities. MATERIAL AND METHODS: Institutional research ethics board approval was obtained. Fetal MRI of 97 singleton pregnancies were analysed retrospectively (19-25 weeks gestation), 65 with CNS morphological abnormalities and 32 controls. Placental T2 signal intensity, placental and fetal volumes, placental-to-fetal volume ratio, and placental apparent diffusion coefficient (ADC) values were assessed...
June 9, 2018: Clinical Radiology
Mariana L Meyers, Jacquelyn R Garcia, Kiara L Blough, Wei Zhang, Christopher I Cassady, Amy R Mehollin-Ray
OBJECTIVE: The purpose of this study is to establish normal total fetal lung volume reference ranges from 18 to 38 weeks' gestation at 1-week intervals. MATERIALS AND METHODS: A retrospective analysis of 665 patients who underwent fetal MRI at two tertiary fetal centers from 2001 to 2013 was performed. Total fetal lung volume was measured in at least two planes, either manually or using a 3D workstation. The mean, median, SD, minimum, maximum, and lower and upper quartiles for total fetal lung volume were determined per gestational week...
June 12, 2018: AJR. American Journal of Roentgenology
Tally Lerman-Sagie, Daniella Prayer, Sophia Stöcklein, Gustavo Malinger
The embryologic development of the cerebellum extends over a long time period, thus making it vulnerable to a broad spectrum of malformations and disruptions. Knowledge of the main steps of fetal posterior fossa development; the normal imaging patterns at different stages of embryogenesis; the large spectrum of cerebellar malformations; and their clinical presentations enables diagnosis and precise counseling of parents. Sonography is the most important imaging method for the screening of cerebellar malformations since it is noninvasive, widely available, and safe for both mother and child...
2018: Handbook of Clinical Neurology
Jiajun Yan, Sipei Li, Francis Cartieri, Zongyu Wang, T Kevin Hitchens, Jody Leonardo, Saadyah E Averick, Krzysztof Matyjaszewski
Novel water-dispersible hybrid iron oxide nanoparticles grafted with a polymeric analogue of dimethylsulfoxide (DMSO) were prepared. Superparamagnetic iron oxide (SPIO) nanoparticles with immobilized atom transfer radical polymerization (ATRP) initiators were prepare via an in situ method using 12-(2-bromoisobutyramido)dodecanoic acid (BiBADA) as a surface ligand/initiator. The initiator-functionalized particles were employed in a surface-initiated initiator for continuous activator regeneration (ICAR) ATRP to graft poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA, a polyacrylate analogue of DMSO) from the surface...
June 11, 2018: ACS Applied Materials & Interfaces
Tayyib T A Hayat, Mary A Rutherford
We are entering a new era of understanding human development with the ability to perform studies at the earliest time points possible. There is a substantial body of evidence to support the concept that early motor behaviour originates from supraspinal motor centres, reflects neurological integrity, and that altered patterns of behaviour may precede clinical manifestation of disease. Cine Magnetic Resonance Imaging (cineMRI) has established its value as a novel method to visualise motor behaviour in the human fetus, building on the wealth of knowledge gleaned from ultrasound sonography based studies...
June 7, 2018: Neuroscience and Biobehavioral Reviews
Mirra Manevich-Mazor, Alina Weissmann-Brenner, Omer Bar Yosef, Chen Hoffmann, Roei David Mazor, Mariela Mosheva, Reuven Ryszard Achiron, Eldad Katorza
OBJECTIVE:  To evaluate the added value of fetal MRI to ultrasound in detecting and specifying callosal anomalies, and its impact on clinical decision making. METHODS:  Fetuses with a sonographic diagnosis of an anomalous corpus callosum (CC) who underwent a subsequent fetal brain MRI between 2010 and 2015 were retrospectively evaluated and classified according to the severity of the findings. The findings detected on ultrasound were compared to those detected on MRI...
June 7, 2018: Ultraschall in der Medizin
Natalia Mandiá, Alejandro Pérez-Muñuzuri, Olalla López-Suárez, Carolina López-Sanguos, Adolfo Bautista-Casanovas, Mariá-Luz Couce
INTRODUCTION: Hereditary multiple intestinal atresia associated with severe combined immunodeficiency (MIA-SCID) is a very rare disease caused by deleterious mutations in the tetratricopeptide repeat domain-containing protein 7A gene TTC7A. It is characterized by intestinal obstruction, sepsis, and a poor prognosis. Insights into phenotype-genotype correlations could help to guide genetic counseling and increase our knowledge of the natural history of this disease. CASE PRESENTATION: We report the case of a newborn in which his fetal magnetic resonance imaging showed jejunal atresia and microcolon and an abdominal x-ray at birth confirmed intestinal obstruction...
June 2018: Medicine (Baltimore)
Peter F R Gunderman, Lindsey A G Shea, Brian W Gray, Brandon P Brown
OBJECTIVE: To review fetal MRI cases surgically proven to have MI and obstruction, describe the common fetal MRI findings that distinguish cases of complicated MI, and to compare these findings with surgical images and perinatal outcomes. METHOD: We performed a retrospective review of all fetal MRI examinations and the corresponding medical record from our tertiary care children's hospital over an 18 month period. Postnatal management and outcomes were reviewed for these patients, and those patients with surgical or postmortem diagnosis of complicated MI were included in the study...
June 7, 2018: Prenatal Diagnosis
Bo S Rasmussen, Celine L Sørensen, Peter V Vester-Glowinski, Mikkel Herly, Sorel Kurbegovic, Mathias Ørholt, Jesper D Svalgaard, Stig-Frederik T Kølle, Annemarie T Kristensen, Maj-Lis M Talman, Krzysztof T Drzewiecki, Anne Fischer-Nielsen
Background: Cell-enriched fat grafting has shown promising results for improving graft survival, although many questions remain unanswered. A large animal model is crucial for bridging the gap between rodent studies and human trials. We present a step-by-step approach in using the Göttingen minipig as a model for future studies of cell-enriched large volume fat grafting. Methods: Fat grafting was performed as bolus injections and structural fat grafting. Graft retention was assessed by magnetic resonance imaging after 120 days...
April 2018: Plastic and Reconstructive Surgery. Global Open
Aurélie D'Hondt, Marie Cassart, Raymond De Maubeuge, Gustavo Soto Ares, Jacques Rommens, E Fred Avni
Postmortem fetal magnetic resonance imaging (PMFMRI) is increasingly used thanks to its good overall concordance with histology paralleling the rising incidence of parental refusal of autopsy. The technique could become a routine clinical examination but it needs to be standardized and conducted by trained radiologists. Such radiologists should be aware of not only the (congenital and acquired) anomalies that can involve the fetus, but also of the "physiological" postmortem changes. In this article, we intend to focus on the contribution of PMFMRI based on the existing literature and on our own experience, as we presently perform the technique routinely in our clinical practice...
June 4, 2018: Insights Into Imaging
Michal Fishel-Bartal, Hadel Watad, Chen Hoffmann, Reuven Achiron, Eran Barzilay, Eldad Katorza
INTRODUCTION: Despite meticulous investigation of polyhydramnios cases, in many of these cases, congenital anomalies are detected only after birth. The aim of our study was to explore the contribution of fetal brain MRI to the detection of CNS anomalies in cases of polyhydramnios. MATERIALS AND METHODS: This was retrospective cohort study on fetuses referred for the investigation of polyhydramnios at a single tertiary center. All fetuses underwent a detailed sonographic anatomical scan and a fetal brain MRI...
June 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
I Pogledic
Disorders of migration and gyration are a versatile group of pathologies that may cause epilepsy and/or neurodevelopmental delay. With the recent improvement of imaging methods, it is possible to detect these pathologies, not only on postnatal MRI but also in utero using fetal MRI. The use of MRI together with genetic tests and knowledge of the classification of these malformations makes early diagnosis possible. Furthermore, the exact diagnosis of disorders of gyration and migration will help ensure better treatment of symptomatic epilepsies as well as be of great help in counselling the parents if detected in utero...
May 30, 2018: Der Radiologe
T Goto, H Kakita, M Takasu, S Takeshita, H Ueda, D Muto, T Kondo, H Kurahashi, A Okumura, Y Yamada
We present here a late preterm infant with extensive brain lesions resulting from vitamin K deficiency. A female infant was born after 35 weeks of gestation by emergent cesarean section because of non-reassuring fetal status. Her mother had severe eating disorder and recurrent vomiting since early pregnancy. She was immediately intubated and ventilated because she was extremely pale, hypotonic, and non-reactive. Cerebral magnetic resonance imaging immediately after birth showed intraparenchymal hemorrhage in the left frontal lobe and cerebellum, marked cerebral edema, and cerebellar hypoplasia...
May 23, 2018: Journal of Neonatal-perinatal Medicine
W Reith, A Haussmann, U Yilmaz
CLINICAL ISSUE: The most important prenatal screening method for the detailed assessment of the fetus is ultrasound, which is often combined with colour-coded Doppler sonography. In case of sonographically diagnosed fetal pathologies or technical limitations of the ultrasound, supplementary diagnostics may be necessary. STANDARD RADIOLOGICAL METHODS: With fast MRI sequences, fetal MRI screening provides important additional information especially with regard to the most common congenital pathologies-central nervous system (CNS) pathologies (agenesis of the corpus callosum, ventriculomegaly, arachnoid cyst, pathologies of the posterior cranial fossa, dysfunction of the gyrification)...
May 28, 2018: Der Radiologe
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