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https://www.readbyqxmd.com/read/29779092/neurodynamic-evaluation-and-nerve-conduction-studies-in-patients-with-forward-head-posture
#1
Tugba Ozudogru Celik, Burcu Duyur Cakit, Baris Nacir, Hakan Genc, Mehmet Onat Cakit, Aynur Karagoz
Forward head posture (FHP) is one of the most frequently seen problems. The aim of this study was to evaluate the neurodynamic tests and peripheral nerve conductions of upper extremity in patients with FHP. The study population included 100 patients with upper extremity and neck problems and 34 healthy individuals as a control group. Craniovertebral angle measurement was used to determine forward head posture. Stretch tests for radial, ulnar and median nerves were performed. Nerve conductions of bilateral median, radial, ulnar and medial antebrachial cutaneous (MAC) nerves were examined in all patients included in the study...
May 19, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29773677/the-relative-resistance-of-children-to-sepsis-mortality-from-pathways-to-drug-candidates
#2
Rose B Joachim, Gabriel M Altschuler, John N Hutchinson, Hector R Wong, Winston A Hide, Lester Kobzik
Attempts to develop drugs that address sepsis based on leads developed in animal models have failed. We sought to identify leads based on human data by exploiting a natural experiment: the relative resistance of children to mortality from severe infections and sepsis. Using public datasets, we identified key differences in pathway activity (Pathprint) in blood transcriptome profiles of septic adults and children. To find drugs that could promote beneficial (child) pathways or inhibit harmful (adult) ones, we built an in silico pathway drug network (PDN) using expression correlation between drug, disease, and pathway gene signatures across 58,475 microarrays...
May 17, 2018: Molecular Systems Biology
https://www.readbyqxmd.com/read/29767372/bayesian-network-to-infer-drug-induced-apoptosis-circuits-from-connectivity-map-data
#3
Jiyang Yu, Jose M Silva
The Connectivity Map (CMAP) project profiled human cancer cell lines exposed to a library of anticancer compounds with the goal of connecting cancer with underlying genes and potential treatments. As most targeted anticancer therapeutics aim to induce tumor-selective apoptosis, it is critical to understand the specific cell death pathways triggered by drugs. This can help to better understand the mechanism of how cancer cells respond to chemical stimulations and improve the treatment of human tumors. In this study, using Connectivity MAP microarray-based gene expression data, we applied a Bayesian network modeling approach and identified apoptosis as a major drug-induced cellular pathway...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29757410/chronic-kidney-disease-and-peripheral-nerve-function-in-the-health-aging-and-body-composition-study
#4
Ranjani N Moorthi, Simit Doshi, Linda F Fried, Sharon M Moe, Mark J Sarnak, Suzanne Satterfield, Ann V Schwartz, Michael Shlipak, Brittney S Lange-Maia, Tamara B Harris, Anne B Newman, Elsa S Strotmeyer
Background: Chronic kidney disease (CKD) is associated with poor mobility. Peripheral nerve function alterations play a significant role in low mobility. We tested the hypothesis that early CKD is associated with altered sensory, motor and autonomic nerve function. Methods: Participants in the Health, Aging and Body Composition cohort who had kidney function measures in Year 3 (1999-2000) and nerve function measurements at Year 4 (2000-01) were analyzed (n = 2290)...
May 10, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29724652/a-novel-homozygous-ndrg1-mutation-in-a-chinese-patient-with-charcot-marie-tooth-disease-4d
#5
Bin Chen, Songtao Niu, Na Chen, Hua Pan, Xingao Wang, Zaiqiang Zhang
Charcot-Marie-Tooth disease 4D (CMT4D) is characterized by severe peripheral neuropathy and deafness. It is caused by mutations in the N-myc downstream-regulated gene 1 (NDRG1). We report a Chinese man with a homozygous mutation c.675C > T of NDRG1 that resulted in Q185X, representing the third known CMT4D patient of non-European ancestry. The patient presented with a 15-year-long history of progressive limb weakness accompanied by hearing loss and dysarthria. There was abnormal differentiation and increased interpeak latencies in brainstem auditory evoked potentials...
April 30, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29721245/an-infantile-alantoaxial-dislocation-with-patent-foramen-ovale-managed-with-titanium-cabling-and-allogenic-bone-grafts
#6
Seidu A Richard, Zhi Gang Lan, Xiao Yang, Siqing Huang
Atlantoaxial dislocation is a disorder that is characterized with loss of stability of the atlas and axis (C1-C2) with consequential loss of usual articulation. Although this condition is very common, no one has reported a case as young as our patients. We present a 7-month infant with bilateral paralysis of the lower limbs for four (4) months with no history of trauma. Computer tomographic (CT-scan) imaging revealed alantoaxial dislocation with severe cervical spinal cord compression. The odontoid process is displaced outwardly with no bone destruction...
March 22, 2018: Pediatric Reports
https://www.readbyqxmd.com/read/29720799/phrenic-nerve-conduction-study-in-the-early-stage-of-guillain-barre-syndrome-as-a-predictor-of-respiratory-failure
#7
Barun Kumar Sen, Alak Pandit
Background: Guillain-Barré syndrome (GBS) has unpredictable clinical course with severe complication of respiratory failure. Objective: To identify clinical profiles and electrophysiological study particularly non-invasive Phrenic nerve conduction study in patients of early GBS to predict respiratory failure. Methods: 64 adult (age≥18yrs) patients of early GBS (onset ≤ 14 days) during the study period from January 2014 to October 2015 were evaluated by clinical profiles of age, gender, antecedent infection, time to peak disability, single breath counts, cranial nerve involvement, autonomic dysfunction and non-invasive Phrenic nerve conduction study...
January 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29705801/assessment-of-embryo-induced-transcriptomic-changes-in-hamster-uterus-using-rna-seq
#8
Ming-Yu Huang, Wen-Qian Zhang, Miao Zhao, Can Zhu, Jia-Peng He, Ji-Long Liu
BACKGROUND/AIMS: The mouse is widely used as an animal model for studying human embryo implantation. However, the mouse is unique in that both ovarian progesterone and estrogen are critical to implantation, whereas in the majority of species (e.g. human and hamster) implantation can occur in the presence of progesterone alone. METHODS: In this study, we analyzed embryo-induced transcriptomic changes in the hamster uterus during embryo implantation by using RNA-seq...
April 25, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29690884/capsaicin-enriched-diet-ameliorates-autoimmune-neuritis-in-rats
#9
Jeremias Motte, Björn Ambrosius, Thomas Grüter, Hussein Bachir, Melissa Sgodzai, Xiomara Pedreiturria, Kalliopi Pitarokoili, Ralf Gold
BACKGROUND: Autoimmune neuropathies are common PNS disorders and effective treatment is challenging. Environmental influence and dietary components are known to affect the course of autoimmune diseases. Capsaicin as pungent component of chili-peppers is common in human nutrition. An influence of capsaicin on autoimmune diseases has been postulated. METHODS: We tested capsaicin in the animal model of experimental autoimmune neuritis (EAN) in Lewis rat. Rats were immunized with P2-peptide and were treated with capsaicin in different preventive settings...
April 24, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29666207/split-hand-muscle-echo-intensity-index-as-a-reliable-imaging-marker-for-differential-diagnosis-of-amyotrophic-lateral-sclerosis
#10
Hung Youl Seok, Jinseok Park, Yoo Hwan Kim, Ki-Wook Oh, Seung Hyun Kim, Byung-Jo Kim
OBJECTIVE: The objective of this study was to investigate the usefulness of muscle ultrasound in evaluating dissociated small hand muscle atrophy, termed 'split hand', and its feasibility in the diagnosis of amyotrophic lateral sclerosis (ALS). METHODS: Forty-four patients with ALS, 18 normal subjects and 9 patients with other neuromuscular disorders were included in this study. The hand muscles were divided into three regions, the median-innervated lateral hand muscle group (ML), the ulnar-innervated lateral hand muscle (UL) and the ulnar-innervated medial hand muscle (UM), and the muscle echo intensity (EI) and compound muscle action potential (CMAP) were measured...
April 17, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29650251/exploring-the-molecular-mechanisms-of-traditional-chinese-medicine-components-using-gene-expression-signatures-and-connectivity-map
#11
Minjae Yoo, Jimin Shin, Hyunmin Kim, Jihye Kim, Jaewoo Kang, Aik Choon Tan
BACKGROUND AND OBJECTIVE: Traditional Chinese Medicine (TCM) has been practiced over thousands of years in China and other Asian countries for treating various symptoms and diseases. However, the underlying molecular mechanisms of TCM are poorly understood, partly due to the "multi-component, multi-target" nature of TCM. To uncover the molecular mechanisms of TCM, we perform comprehensive gene expression analysis using connectivity map. METHODS: We interrogated gene expression signatures obtained 102 TCM components using the next generation Connectivity Map (CMap) resource...
April 4, 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29605618/progressive-myoclonus-epilepsy-without-renal-failure-in-a-chinese-family-with-a-novel-mutation-in-scarb2-gene-and-literature-review
#12
Wo-Tu Tian, Xiao-Li Liu, Yang-Qi Xu, Xiao-Jun Huang, Hai-Yan Zhou, Ying Wang, Hui-Dong Tang, Sheng-Di Chen, Xing-Hua Luan, Li Cao
PURPOSE: To describe the clinical and genetic features of a Chinese progressive myoclonus epilepsy (PME) patient related with SCARB2 mutation without renal impairment and review 27 SCARB2-related PME patients from 11 countries. METHODS: The patient was a 27-year-old man with progressive action myoclonus, ataxia, epilepsy, dysarthria and absence of cognitive deterioration. Renal functional test was normal. Electroencephalography (EEG) showed progressively slowed background activity and sporadic generalized spike-and-wave discharges...
March 14, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29605259/gene-expression-profiling-coupled-with-connectivity-map-database-mining-reveals-potential-therapeutic-drugs-for-hirschsprung-disease
#13
Shang-Jie Xiao, Xiao-Chun Zhu, Hua Deng, Wei-Ping Zhou, Wen-Yi Yang, Li-Ke Yuan, Jiang-Yu Zhang, Song Tian, Lu Xu, Liang Zhang, Hui-Min Xia
BACKGROUND: Hirschsprung disease (HD) is a congenital intestinal anomaly resulting from a failure to form enteric ganglia in the lower bowel. Surgery is the main therapeutic strategy, although neural stem cell transplantation has recently shown promise. However, HD remains a challenging disorder to treat. Our aim was to identify drugs that could counteract the dysregulated pathways in HD and could thus be potential novel therapies. METHODS: We used microarray analysis to identify genes differentially expressed in ganglionic and aganglionic bowel samples from eight children with HD...
March 4, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29596905/rapamycin-modulates-glucocorticoid-receptor-function-blocks-atrophogene-redd1-and-protects-skin-from-steroid-atrophy
#14
Ekaterina Lesovaya, Shivani Agarwal, Ben Readhead, Elena Vinokour, Gleb Baida, Pankaj Bhalla, Kirill Kirsanov, Marianna Yakubovskaya, Leonidas C Platanias, Joel T Dudley, Irina Budunova
Glucocorticoids have excellent therapeutic properties; however, they cause significant adverse atrophogenic effects. mTOR complex 1 (mTORC1) inhibitor, REDD1 (regulated in development and DNA damage 1), has been recently identified as a key mediator of glucocorticoid-induced atrophy. We performed computational screening of connectivity map database (CMAP) to identify putative REDD1 inhibitors. The top selected candidates included Rapamycin, which was unexpected because it inhibits pro-proliferative mTOR signaling...
March 26, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29588458/personalised-drug-repositioning-for-clear-cell-renal-cell-carcinoma-using-gene-expression
#15
Karel K M Koudijs, Anton G T Terwisscha van Scheltinga, Stefan Böhringer, Kirsten J M Schimmel, Henk-Jan Guchelaar
Reversal of cancer gene expression is predictive of therapeutic potential and can be used to find new indications for existing drugs (drug repositioning). Gene expression reversal potential is currently calculated, in almost all studies, by pre-aggregating all tumour samples into a single group signature or a limited number of molecular subtype signatures. Here, we investigate whether drug repositioning based on individual tumour sample gene expression signatures outperforms the use of tumour group and subtype signatures...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29574457/characteristics-of-phrenic-nerve-injury-during-pulmonary-vein-isolation-using-a-28-mm-second-generation-cryoballoon-and-short-freeze-strategy
#16
Shinsuke Miyazaki, Takatsugu Kajiyama, Tomonori Watanabe, Masahiro Hada, Kazuya Yamao, Shigeki Kusa, Miyako Igarashi, Hiroaki Nakamura, Hitoshi Hachiya, Hiroshi Tada, Kenzo Hirao, Yoshito Iesaka
BACKGROUND: The reported incidence of phrenic nerve injury (PNI) varies owing to different definitions, balloon generations, balloon size, freezing regimen, and protective maneuvers. We evaluated the incidence, predictors, and outcome of PNI during cryoballoon pulmonary vein isolation in a large population. METHODS AND RESULTS: Five hundred fifty atrial fibrillation patients underwent pulmonary vein isolation using one 28-mm second-generation cryoballoon and single 3-minute freeze strategy under diaphragmatic compound motor action potential (CMAP) monitoring...
March 24, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29558515/new-drug-candidates-for-treatment-of-atypical-meningiomas-an-integrated-approach-using-gene-expression-signatures-for-drug-repurposing
#17
Zsolt Zador, Andrew T King, Nophar Geifman
BACKGROUND: Atypical meningiomas are common central nervous system neoplasms with high recurrence rate and poorer prognosis compared to their grade I counterparts. Surgical excision and radiotherapy remains the mainstay therapy but medical treatments are limited. We explore new drug candidates using computational drug repurposing based on the gene expression signature of atypical meningioma tissue with subsequent analysis of drug-generated expression profiles. We further explore possible mechanisms of action for the identified drug candidates using ingenuity pathway analysis (IPA)...
2018: PloS One
https://www.readbyqxmd.com/read/29554582/on-the-electrode-positioning-for-bipolar-emg-recording-of-forearm-extensor-and-flexor-muscle-activity-after-transcranial-magnetic-stimulation
#18
Moniek A M Munneke, Chantal D Bakker, Eline A Goverde, Jaco W Pasman, Dick F Stegeman
After stroke, motor pathways are often affected, leading to paresis. It remains difficult to reliably predict motor recovery of the upper extremity, for which transcranial magnetic stimulation (TMS) may add to clinical examination. Placement of the surface electromyography (sEMG) electrodes in TMS is essential for information about specific muscle groups and corticospinal pathways. This study primarily aimed to determine the optimal sEMG electrode positions for recording activity of forearm flexor and extensor muscles...
March 1, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29550653/creatine-kinase-level-and-its-relationship-with-quantitative-electromyographic-characteristics-in-amyotrophic-lateral-sclerosis
#19
Hongfei Tai, Liying Cui, Mingsheng Liu, Yuzhou Guan, Xiaoguang Li, Dongchao Shen, Kang Zhang, Shuangwu Liu, Shuang Wu, Qingyun Ding, Youfang Hu
OBJECTIVE: To explore the relationship between serum creatine kinase (CK) level and electromyographic characteristics in patients with amyotrophic lateral sclerosis (ALS). METHODS: Two hundred thirty-eight consecutive ALS patients were enrolled. All patients underwent electrophysiological study with a consistent approach. We calculated a compound muscle action potential (CMAP) sum score, and spontaneous potentials were graded from 0 to 4 depending on their density and distribution...
February 20, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29531920/ultrasonography-predictive-factors-of-response-to-local-steroid-injection-in-patients-with-carpal-tunnel-syndrome
#20
Farnaz Dehghan, Shila Haghighat, Hadiseh Ramezanian, Mehdi Karami, Mohammad Reza Rezaei
Background: The aim of this study is to determine the predictive value of ultrasonography for results of local steroid injection in patients with carpal tunnel syndrome (CTS). Materials and Methods: This prospective cohort study was conducted during a 1-year period in outpatient clinics of rehabilitation and physical medicine including 35 patients with moderate and severe CTS who receive ultrasonography-guided local steroid injection. The Boston self-assessment questionnaire and electrodiagnosis parameters were recorded at baseline, 1 month, and 3 months after therapy...
2018: Advanced Biomedical Research
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