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https://www.readbyqxmd.com/read/28434449/electrical-superior-vena-cava-isolation-using-a-novel-pace-and-ablate-technique-under-diaphragmatic-electromyography-monitoring
#1
Shinsuke Miyazaki, Shigeki Kusa, Hitoshi Hachiya, Hiroshi Taniguchi, Takayuki Niida, Sadamitsu Ichijo, Kenzo Hirao, Yoshito Iesaka
BACKGROUND: Diaphragmatic compound motor action potential (CMAP) amplitude monitoring is a standard technique to anticipate phrenic nerve injury during cryoballoon ablation. OBJECTIVE: The purpose of this study was to evaluate the feasibility of a novel superior vena cava isolation (SVCI) technique using simultaneous pacing and ablation through the tip of a single mapping/ablation catheter. METHODS: Fifty-four patients with atrial fibrillation were included...
May 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28432749/motor-nerve-excitability-after-childhood-guillain-barr%C3%A3-syndrome
#2
Judith Drenthen, Joyce Roodbol, Ellen M Maathuis, Coriene E Catsman-Berrevoets, Joleen H Blok, Marie-Claire Y de Wit, Bart C Jacobs
OBJECTIVE: To determine the residual motor nerve dysfunction after pediatric Guillain-Barré syndrome (GBS). METHODS: Observational cross-sectional cohort study in patients who previously developed GBS during childhood (<18 years). Ulnar motor nerve dysfunction was defined by compound motor action potential (CMAP) scan in patients after a follow-up of at least one year compared with age-matched healthy controls, in relation to clinical course and outcome. RESULTS: Thirty-seven persons previously diagnosed with GBS in childhood were included with a mean age at current examination of 20...
April 21, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/28429469/high-body-mass-and-kidney-dysfunction-relate-to-worse-nerve-function-even-in-adults-without-neuropathy
#3
Rens Hanewinckel, M Arfan Ikram, Oscar H Franco, Albert Hofman, Judith Drenthen, Pieter A van Doorn
Polyneuropathy is a prevalent and disabling disorder. Despite extensive evaluation, the cause often remains unknown. Factors that predispose for the development of polyneuropathy need to be identified. We investigated the effect of anthropometric and metabolic factors on peripheral nerve function in 908 participants of the population-based Rotterdam Study without any symptoms or signs of polyneuropathy. Participants underwent nerve conduction studies of the sural and peroneal nerve. Data on age, height, weight, waist circumference, diabetes, lipid levels, hypertension and kidney function were collected...
April 20, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/28423347/experimental-study-of-brachial-plexus-and-vessel-compression-evaluation-of-combined-central-and-peripheral-electrodiagnostic-approach
#4
Chaoqun Yang, Jianguang Xu, Jie Chen, Shulin Li, Yu Cao, Yi Zhu, Lei Xu
INTRODUCTION: We sought to investigate the reliability of a new electrodiagnostic method for identifying Electrodiagnosis of Brachial Plexus & Vessel Compression Syndrome (BPVCS) in rats that involves the application of transcranial electrical stimulation motor evoked potentials (TES-MEPs) combined with peripheral nerve stimulation compound muscle action potentials (PNS-CMAPs). RESULTS: The latencies of the TES-MEP and PNS-CMAP were initially elongated in the 8-week group...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422939/predictive-factors-for-achieving-independent-walking-in-children-with-guillain-barre-syndrome
#5
Mohammad Barzegar, Vahideh Toopchizadeh, Mohammad Hk Maher, Paria Sadeghi, Fatemeh Jahanjoo, Alireza Pishgahi
BACKGROUND: To determine the predictors of achieving independent walking at 2 and 6 months after onset of weakness in children with Guillain-Barre Syndrome (GBS). METHODS: Children with GBS admitted to Tabriz Children's Hospital were studied prospectively. All patients had frequent clinical evaluations until achieving independent walking. Unaided walking at 2 and 6 months, and factors influencing these outcomes were determined using both univariate and multiple analysis...
April 19, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28400096/the-evolution-of-motor-cortical-dysfunction-in-amyotrophic-lateral-sclerosis
#6
Kazumoto Shibuya, Neil G Simon, Nimeshan Geevasinga, Parvathi Menon, James Howells, Susanna B Park, William Huynh, Yu-Ichi Noto, Steve Vucic, Matthew C Kiernan
OBJECTIVE: The present study aimed to investigate alterations in cortical function in amyotrophic lateral sclerosis (ALS) related to disease progression. METHODS: In total, clinical assessments were evaluated in 189 ALS patients, combined with assessment of cortical function utilising threshold tracking transcranial magnetic stimulation. Results were compared with disease stage. Disease stage was defined in three ways: (1) as a proportion of disease duration in deceased patients; (2) from the time of ALS onset; and (3) using the ALS rating scale-revised (ALSFRS-R)...
March 15, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28397268/optimization-of-the-gbmv2-implicit-solvent-force-field-for-accurate-simulation-of-protein-conformational-equilibria
#7
Kuo Hao Lee, Jianhan Chen
Accurate treatment of solvent environment is critical for reliable simulations of protein conformational equilibria. Implicit treatment of solvation, such as using the generalized Born (GB) class of models arguably provides an optimal balance between computational efficiency and physical accuracy. Yet, GB models are frequently plagued by a tendency to generate overly compact structures. The physical origins of this drawback are relatively well understood, and the key to a balanced implicit solvent protein force field is careful optimization of physical parameters to achieve a sufficient level of cancellation of errors...
April 11, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28374700/-decrement-pattern-of-m-response-amplitude-in-the-low-frequency-repetitive-nerve-stimulation-in-the-muscles-of-patients-with-myasthenia-gravis-and-lambert-eaton-myasthenic-syndrome
#8
D A Tumurov, A G Sanadze
AIM: To investigate the pattern of decrement in the muscles of patients with myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS). MATERIAL AND METHODS: Twenty-seven patients with MG and 39 patients with LEMS were studied using low frequency repetitive nerve stimulation (3/ sec). RESULTS AND CONCLUSION: The decrease of safety factor of neuromuscular transmission was equal in both groups. At the same time, a significant difference in the decrease of pattern of the amplitude compound of muscle action potential (CMAP) was found...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28364332/repetitive-nerve-stimulation-as-a-diagnostic-aid-for-distinguishing-cervical-spondylotic-amyotrophy-from-amyotrophic-lateral-sclerosis
#9
Chaojun Zheng, Xiang Jin, Yu Zhu, Feizhou Lu, Jianyuan Jiang, Xinlei Xia
PURPOSE: To identify and compare the features of compound muscle action potential (CMAP) decrements in repetitive nerve stimulation (RNS) in patients with cervical spondylotic amyotrophy (CSA) and in patients with amyotrophic lateral sclerosis (ALS). METHODS: The cohort consisted of 43 CSA (distal-type to proximal-type ratio: 27-16) and 35 ALS patients. Five muscles, including abductor pollicis brevis (APB), abductor digiti minimi (ADM), biceps brachii (BB), middle deltoid (Del), and upper trapezius (Trap), were tested by 3-Hz RNS...
March 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28364294/intermediate-charcot-marie-tooth-disease-an-electrophysiological-reappraisal-and-systematic-review
#10
REVIEW
José Berciano, Antonio García, Elena Gallardo, Kristien Peeters, Ana L Pelayo-Negro, Silvia Álvarez-Paradelo, José Gazulla, Miriam Martínez-Tames, Jon Infante, Albena Jordanova
Charcot-Marie-Tooth disease (CMT) is the most frequent form of inherited neuropathy with great variety of phenotypes, inheritance patterns, and causative genes. According to median motor nerve conduction velocity (MNCV), CMT is divided into demyelinating (CMT1) with MNCV below 38 m/s, axonal (CMT2) with MNCV above 38 m/s, and intermediate CMT with MNCV between 25 and 45 m/s. In each category, transmission may be autosomal dominant, autosomal recessive, or X-linked. The nosology of intermediate CMT is controversial because of concerns about electrophysiological delimitation...
March 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28364031/the-effect-of-acute-maximal-exercise-on-postexercise-hemodynamics-and-central-arterial-stiffness-in-obese-and-normal-weight-individuals
#11
Kanokwan Bunsawat, Sushant M Ranadive, Abbi D Lane-Cordova, Huimin Yan, Rebecca M Kappus, Bo Fernhall, Tracy Baynard
Central arterial stiffness is associated with incident hypertension and negative cardiovascular outcomes. Obese individuals have higher central blood pressure (BP) and central arterial stiffness than their normal-weight counterparts, but it is unclear whether obesity also affects hemodynamics and central arterial stiffness after maximal exercise. We evaluated central hemodynamics and arterial stiffness during recovery from acute maximal aerobic exercise in obese and normal-weight individuals. Forty-six normal-weight and twenty-one obese individuals underwent measurements of central BP and central arterial stiffness at rest and 15 and 30 min following acute maximal exercise...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28360533/effects-of-decompression-on-behavioral-electrophysiologic-and-histomorphologic-recovery-in-a-chronic-sciatic-nerve-compression-model-of-streptozotocin-induced-diabetic-rats
#12
Ping-Hui Wang, Cheng-Chang Yang, Wei-Ren Su, Po-Ting Wu, Shun-Chien Cheng, I-Ming Jou
PURPOSE: To determine susceptibility to decompression surgery in diabetic and nondiabetic peripheral neuropathy using a chronic compression neuropathy model. MATERIALS AND METHODS: Twenty-four streptozotocin-induced diabetic rats were randomly divided into three groups: group I, chronic compression of the left sciatic nerve for 4 weeks with decompression; group II, similar without decompression; and group III, sham exposing the sciatic nerve only. The other 24 nondiabetic rats were assigned to groups IV-VI, which received compression-decompression, compression, and the sham operation, respectively...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28350803/pharmacogenomic-identification-of-small-molecules-for-lineage-specific-manipulation-of-subventricular-zone-germinal-activity
#13
Kasum Azim, Diane Angonin, Guillaume Marcy, Francesca Pieropan, Andrea Rivera, Vanessa Donega, Claudio Cantù, Gareth Williams, Benedikt Berninger, Arthur M Butt, Olivier Raineteau
Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28344816/vibration-upshot-of-operating-mechanical-sewing-machine-an-insight-into-common-peroneal-nerve-conduction-study
#14
Prakash Kumar Yadav, Ram Lochan Yadav, Deepak Sharma, Dev Kumar Shah, Niraj Khatri Sapkota, Dilip Thakur, Nirmala Limbu, Md Nazrul Islam
BACKGROUND: Most of the people associated with tailoring occupation in Nepal are still using mechanical sewing machine as an alternative of new technology for tailoring. Common peroneal nerves of both right and left legs are exposed to strenuous and chronic stress exerted by vibration and paddling of mechanical sewing machine. METHODS: The study included 30 healthy male tailors and 30 healthy male individuals. Anthropometric variables as well as cardio respiratory variables were determined for each subject...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28336967/the-gene-expression-profiles-in-response-to-102-traditional-chinese-medicine-tcm-components-a-general-template-for-research-on-tcms
#15
Chao Lv, Xueting Wu, Xia Wang, Juan Su, Huawu Zeng, Jing Zhao, Shan Lin, Runhui Liu, Honglin Li, Xuan Li, Weidong Zhang
Traditional Chinese medicines (TCMs) have important therapeutic value in long-term clinical practice. However, because TCMs contain diverse ingredients and have complex effects on the human body, the molecular mechanisms of TCMs are poorly understood. In this work, we determined the gene expression profiles of cells in response to TCM components to investigate TCM activities at the molecular and cellular levels. MCF7 cells were separately treated with 102 different molecules from TCMs, and their gene expression profiles were compared with the Connectivity Map (CMAP)...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28332470/adult-onset-demyelinating-neuropathy-associated-with-fbln5-gene-mutation
#16
Si Cheng, He Lv, Wei Zhang, Zhaoxia Wang, Xin Shi, Wei Liang, Yun Yuan
Rare forms of autosomal-dominant Charcot-Marie-Tooth disease (AD-CMT) may be associated with mutations in Fibulin-5 (FBLN5) as AD-CMT is genetically heterogeneous. Here, we report the first pathological study of an Asian family. The proband was a 46-year-old man with slowly progressive distal numbness and weakness for 12 years. He had a history of diabetes mellitus for 12 years. His mother was 81 years old and had mild polyneuropathy. His 16-year-old daughter was asymptomatic. The nerve conduction velocities (NCVs) and compound muscular action potential (CMAP) amplitudes were moderately to severely reduced in the proband, and moderately reduced in his daughter and mother...
March 23, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28325700/the-relationship-between-preoperative-needle-electromyography-findings-and-muscle-power-restoration-after-surgery-in-severe-carpal-tunnel-syndrome-patients
#17
Yuki Hara, Yasumasa Nishiura, Naoyuki Ochiai, Shinji Murai, Masashi Yamazaki
PURPOSE: Needle electromyography provides essential information about the functional aspects of the muscle. But little attention has been given in the literature to needle electromyography examinations in carpal tunnel syndrome. We examined the relationship between preoperative needle electromyography findings and functional recovery of the abductor pollicis brevis (APB) muscle in severe carpal tunnel syndrome patients. METHODS: The subjects of this study were 49 patients, 58 hands, who fit the following 5 criteria: (1) idiopathic carpal tunnel syndrome; (2) pre-op MMT grade of the APB muscle was M0 or M1; (3) APB-CMAP (compound muscle action potential) was not evoked in a median nerve conduction study; (4) needle electromyography of the APB muscle had been done; (5) underwent carpal tunnel release only...
March 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28319875/electrophysiologic-features-of-ulnar-neuropathy-in-childhood-and-adolescence
#18
Ioannis Karakis, Wendy Liew, Heather Szelag Fournier, H Royden Jones, Basil T Darras, Peter B Kang
OBJECTIVE: To analyze patterns of nerve injury in pediatric ulnar neuropathy (PUN). METHODS: Retrospective analysis of 49 children with PUN. RESULTS: Sensory loss in digit V was the prevailing complaint (89%). Predominant localization was at the elbow (55%). Diminished ulnar SNAP was the most common abnormality (71%) with median axon loss estimate (MAXE) of 62%. Dorsal ulnar cutaneous (DUC) sensory nerve action potential (SNAP) was reduced in 55% with MAXE of 43%...
May 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28287078/the-design-of-and-chronic-tissue-response-to-a-composite-nerve-electrode-with-patterned-stiffness
#19
M J Freeberg, M A Stone, R J Triolo, D J Tyler
OBJECTIVE: As neural interfaces demonstrate success in chronic applications, a novel class of reshaping electrodes with patterned regions of stiffness will enable application to a widening range of anatomical locations. Patterning stiff regions and flexible regions of the electrode enables nerve reshaping while accommodating anatomical constraints of various implant locations ranging from peripheral nerves to spinal and autonomic plexi. APPROACH: Introduced is a new composite electrode enabling patterning of regions of various electrode mechanical properties...
March 13, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28256512/transcriptome-based-repurposing-of-apigenin-as-a-potential-anti-fibrotic-agent-targeting-hepatic-stellate-cells
#20
Daniel F Hicks, Nicolas Goossens, Ana Blas-García, Takuma Tsuchida, Benjamin Wooden, Michael C Wallace, Natalia Nieto, Abigale Lade, Benjamin Redhead, Arthur I Cederbaum, Joel T Dudley, Bryan C Fuchs, Youngmin A Lee, Yujin Hoshida, Scott L Friedman
We have used a computational approach to identify anti-fibrotic therapies by querying a transcriptome. A transcriptome signature of activated hepatic stellate cells (HSCs), the primary collagen-secreting cell in liver, and queried against a transcriptomic database that quantifies changes in gene expression in response to 1,309 FDA-approved drugs and bioactives (CMap). The flavonoid apigenin was among 9 top-ranked compounds predicted to have anti-fibrotic activity; indeed, apigenin dose-dependently reduced collagen I in the human HSC line, TWNT-4...
March 3, 2017: Scientific Reports
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