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https://www.readbyqxmd.com/read/28780847/-characteristics-of-repetitive-nerve-stimulation-in-53-cases-of-amyotrophic-lateral-sclerosis
#1
W X Liu, Z H Chen, L Ling, Y T Ren, B Sun, F Yang, F Cui, X S Huang
Objective: To investigate the feature of repetitive nerve stimulation (RNS) in patients with amyotrophic lateral sclerosis (ALS) and correlation between RNS and clinical features and electromyography (EMG) findings of the corresponding muscle. Methods: Needle EMG and RNS were performed in 53 patients with ALS, who were recruited into Department of Neurology of Chinese PLA general hospital during April to December in 2016. Decrement of the compond muscle action potential (CMAP) in response to RNS of different nerves and stimulus frequencies was compared...
August 1, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28766024/usefulness-of-intraoperative-electromyographic-monitoring-of-oculomotor-and-abducens-nerves-during-skull-base-surgery
#2
Zi-Yi Li, Ming-Chu Li, Jian-Tao Liang, Yu-Hai Bao, Ge Chen, Hong-Chuan Guo, Feng Ling
BACKGROUND: Intraoperative neurophysiologic monitoring of the extraocular cranial nerve (EOCN) is not commonly performed because of technical difficulty and risk, reliability of the result and predictability of the postoperative function of the EOCN. METHODS: We performed oculomotor nerve (CN III) and abducens nerve (CN VI) intraoperative monitoring in patients with skull base surgery by recording the spontaneous muscle activity (SMA) and compound muscle action potential (CMAP)...
August 2, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28759703/extracorporeal-shock-wave-treatment-can-selectively-destroy-endplates-in-neuromuscular-junctions
#3
Tomonori Kenmoku, Noriko Nemoto, Nahoko Iwakura, Nobuyasu Ochiai, Kentaro Uchida, Takashi Saisu, Seiji Ohtori, Koichi Nakagawa, Takahisa Sasho, Masashi Takaso
INTRODUCTION: This study assessed the effect of radial extracorporeal shock wave (rESW) exposure on neuromuscular transmission and neuromuscular junction (NMJ) morphology. METHODS: We applied 2,000 rESWs at 0.18 mJ/mm(2) and a frequency of 15 Hz to the right calf of male rats, measured the compound muscle action potential (CMAP) and examined NMJ morphology using electron microscopy. Left calf muscles were used as controls. RESULTS: rESW exposure significantly reduced CMAP amplitude without delayed latency in exposed muscles compared to controls...
July 31, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28747603/autoinflammatory-diseases-in-dermatology-ditra-and-camps
#4
Kazumitsu Sugiura
  Deficiency of interleukin thirty-six receptor antagonist (DITRA) and CARD14 mediated psoriasis (CAMPS) are autoinflammatory diseases in dermatology. The causative genes of DITRA and CMAPS have been identified recently. In this paper, IL36RN and CARD14, the causative gene for DITRA and CAMPS, respectively were explained. In addition, clinical features and therapies for generalized pustular psoriasis not associated with psoriasis vulgaris (GPP without PsV), and pityriasis rubra pilaris type V (PRP type V) were described...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28736099/selective-anterior-interosseous-nerve-conduction-study-coaxial-needle-versus-surface-electrode-recordings
#5
Paul Seror
OBJECTIVES: The aim is to determine which method provides the most selective motor nerve conduction of the anterior interosseous nerve (AIN), when the stimulation cannot be restricted to this nerve. METHODS: The AIN was stimulated at the elbow, along with the whole median nerve. The motor action potential (MAP) of the AIN was recorded with 2 different methods: 1 - a coaxial needle inserted in the pronator quadratus muscle (PQ); 2 - a pair of surface electrodes fixed on the PQ...
July 20, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28710861/differential-protein-modulation-by-ketoprofen-and-ibuprofen-underlines-different-cellular-response-by-gastric-epithelium
#6
L Brandolini, M d'Angelo, A Antonosante, S Villa, L Cristiano, V Castelli, E Benedetti, M Catanesi, A Aramini, A Luini, S Parashuraman, E Mayo, A Giordano, A Cimini, M Allegretti
Ketoprofen L-lysine salt (KLS), is widely used due to its analgesic efficacy and tolerability, and L-lysine was reported to increase the solubility and the gastric tolerance of ketoprofen. In a recent report, L-lysine salification has been shown to exert a gastroprotective effect due to its specific ability to counteract the NSAIDs-induced oxidative stress and up-regulate gastroprotective proteins. In order to derive further insights into the safety and efficacy profile of KLS, in this study we additionally compared the effect of lysine and arginine, another amino acid counterion commonly used for NSAIDs salification, in control and in ethanol challenged human gastric mucosa model...
July 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28709849/effects-of-huperzin-a-on-the-beta-amyloid-accumulation-in-the-brain-and-skeletal-muscle-cells-of-a-rat-model-for-alzheimer-s-disease
#7
Cagatay Han Turkseven, Belgin Buyukakilli, Ebru Balli, Derya Yetkin, Mehmet Emin Erdal, Senay Gorucu Yilmaz, Leyla Sahin
AIMS: Alzheimer's Disease (AD) is characterized by a loss of cognitive function and also the accumulation of β-amyloid peptide (βAP) in the brain parenchyma, which plays an important role in this disease. However, it is often also associated with the non-cognitive symptoms such as loss of muscle function (Inclusion-Body Myositis-IBM). MAIN METHODS: Sprague-Dawley rats (13 weeks-n=68) were randomly assigned into five groups: Group C: Control; Group D: d-galactose; Group O+D: Bilateral oophorectomy+d-galactose; Group O: Bilateral oophorectomy; Group O+D+H: Bilateral oophorectomy+d-galactose+Hup-A...
September 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28685718/clinical-characteristics-electrophysiology-and-skin-biopsy-of-38-peripheral-neuropathy-cases-with-small-fiber-involvement-of-various-etiologies
#8
Bo Sun, Li-Zhi Liu, Yi-Fan Li, Zhao-Hui Chen, Li Ling, Fei Yang, Fang Cui, Xu-Sheng Huang
BACKGROUND: In small fiber neuropathy (SFN), thinly myelinated Aδ and unmyelinated C fibers are primarily affected, resulting in sensory and/or autonomic symptoms. Various etiologies have been shown to be associated with SFN. This study was aimed to analyze a variety of features in peripheral neuropathy (PN) with small fiber involvement, and to compare disease severity among patients with idiopathic PN, PN associated with impaired glucose tolerance (IGT), and metabolic syndrome (MS) PN...
July 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28665027/nerve-conduction-study-of-lower-extremities-in-cutaneous-arteritis-patients-with-neurological-manifestations
#9
Kenji Isahaya, Tamihiro Kawakami, Makoto Shiraishi, Hisanao Akiyama, Yasuhiro Hasegawa
Some patients originally diagnosed with cutaneous arteritis (CA) could develop additional disease manifestations, including peripheral neurological involvement. We evaluated the biological neurological parameters among CA patients who underwent nerve conduction studies for neurological involvement in the lower extremities. We reviewed 164 patients who were originally diagnosed with CA at our dermatology department between 2004 and 2015. Seventeen (10.4%) of the CA patients underwent further nerve conduction studies to determine their peripheral neurological manifestations, primarily in the lower extremities, in our neurology division...
June 30, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28646568/blink-r1-latency-utility-in-diagnosis-and-treatment-assessment-of-poems-and-cidp
#10
Wei Wang, William J Litchy, Michelle L Mauermann, P James B Dyck, Angela Dispenzieri, Jay Mandrekar, Peter J Dyck, Christopher J Klein
INTRODUCTION: In POEMS and CIDP, limb nerve conduction studies (NCS) are limited in identifying demyelination and detecting treatment effects in severely affected patients. Blink R1-latency may improve these assessments. METHODS: POEMS and CIDP patients having undergone NCS and blink reflex were identified. Correlations between R1-latency, limb NCS and neuropathy impairment scores (NIS) were compared. RESULTS: With182 patients (124 POEMS, 58 CIDP) identified, R1-prolongation (>13ms) occurred in 64...
June 23, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28646510/compound-muscle-action-potential-duration-in-critical-illness-neuromyopathy
#11
Christopher L Kramer, Andrea J Boon, C Michel Harper, Brent P Goodman
BACKGROUND: We sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions. METHODS: Fifty-eight patients with CINM seen over a 17-year period were retrospectively studied. Electrodiagnostic findings of the CINM cohort were compared with patients with axonal peripheral neuropathy and myopathy due to other causes...
June 23, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28632137/electrospun-silk-polyaniline-conduits-for-functional-nerve-regeneration-in-rat-sciatic-nerve-injury-model
#12
Suradip Das, Manav Sharma, Dhiren Saharia, Kushal Sarma, Elizabeth Muir, Utpal Bora
The present study describes the fabrication of polyaniline-silk fibroin nanocomposite based nerve conduits and its subsequent implantation in a rat sciatic nerve injury model for peripheral nerve regeneration. This is the first in vivo study of polyaniline based nerve conduit describing the safety and efficacy of the conduits in treating peripheral nerve injuries. The nanocomposite was synthesised by electrospinning a mixture of silk fibroin protein and polyaniline wherein the silk nanofibers were observed to be uniformly coated with polyaniline nanoparticles...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28624492/cortical-function-and-corticomotoneuronal-adaptation-in-monomelic-amyotrophy
#13
José Manuel Matamala, Nimeshan Geevasinga, William Huynh, Thanuja Dharmadasa, James Howells, Neil G Simon, Parvathi Menon, Steve Vucic, Matthew C Kiernan
OBJECTIVE: To evaluate corticomotoneuronal integrity in monomelic amyotrophy using threshold tracking transcranial magnetic stimulation (TT-TMS). METHODS: Cortical excitability studies were prospectively performed in 8 monomelic amyotrophy patients and compared to 21 early-onset amyotrophic lateral sclerosis (ALS) patients and 40 healthy controls. Motor evoked potentials responses were recorded over abductor pollicis brevis. RESULTS: Maximal motor evoked potential (MEP/CMAP ratio) was significantly increased in monomelic amyotrophy compared with controls (monomelic amyotrophy 51...
May 17, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28616933/split-hand-index-and-ulnar-to-median-ratio-in-hirayama-disease-and-amyotrophic-lateral-sclerosis
#14
Jayantee Kalita, Surendra Kumar, Usha K Misra, Zafar Neyaz
OBJECTIVE: We report the relative usefulness of split hand index (SHI) and ulnar to median (UM) ratio in Hirayama disease (HD) and amyotrophic lateral sclerosis (ALS). METHODS: The patients with HD, ALS and matched controls were subjected to evaluation of UM ratio and SHI. Compound muscle action potentials (CMAPs) were recorded from abductor digit minimi (ADM) and first dorsal interosseous (FDI) by stimulating ulnar nerve at the wrist, and abductor pollicis brevis (APB) by stimulating median nerve at the wrist...
June 15, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28615526/identifying-prognostic-signature-in-ovarian-cancer-using-dirgenerank
#15
Jian-Yong Wang, Ling-Ling Chen, Xiong-Hui Zhou
Identifying the prognostic genes in cancer is essential not only for the treatment of cancer patients, but also for drug discovery. However, it's still a big challenge to select the prognostic genes that can distinguish the risk of cancer patients across various data sets because of tumor heterogeneity. In this situation, the selected genes whose expression levels are statistically related to prognostic risks may be passengers. In this paper, based on gene expression data and prognostic data of ovarian cancer patients, we used conditional mutual information to construct gene dependency network in which the nodes (genes) with more out-degrees have more chances to be the modulators of cancer prognosis...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28599476/identification-of-gene-markers-associated-with-metastasis-in-clear-cell-renal-cell-carcinoma
#16
Hailing Yang, Pengfei Huo, Guozhang Hu, Bo Wei, Dalian Kong, Hongjun Li
The present study aimed to screen potential target genes for the early diagnosis and treatment of early metastatic clear cell renal cell carcinoma (ccRCC) using the microarray data of early metastatic and non-metastatic ccRCC samples. The DNA microarray dataset GSE47352 was downloaded from Gene Expression Omnibus and included 4 early metastatic and 5 non-metastatic ccRCC samples. Differentially expressed genes (DEGs) were screened using the limma package. Then, pheatmap package was used to conduct two-way clustering for the DEGs...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28593000/ultrasound-and-emg-ncv-study-electromyography-and-nerve-conduction-velocity-correlation-in-diagnosis-of-nerve-pathologies
#17
REVIEW
Shilpa Domkundwar, Gayatri Autkar, S V Khadilkar, Mayur Virarkar
PURPOSE: Nerve disorders are commonly encountered in clinical practice. Ultrasonography (USG) is a useful modality in the evaluation of most of the peripheral and superficial pathologies amenable to penetration by ultrasound. The primary objective is to study the USG findings of various peripheral nerve pathologies and to correlate them with electrophysiological (EMG-NCV) findings. METHOD: 42 patients referred with suspicion of peripheral nervous system affection were evaluated with USG along with EMG-NCV...
June 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28587109/identification-of-non-electrophilic-nrf2-activators-from-approved-drugs
#18
Qing-Ye Zhang, Xin-Yi Chu, Ling-Han Jiang, Meng-Yuan Liu, Zhi-Ling Mei, Hong-Yu Zhang
Oxidative damage can lead to a wide range of diseases. Nrf2 is an important transcription factor that regulates many of the cytoprotective enzymes involved in the oxidative stress response. Therefore, targeting the regulation of Nrf2 activation is one logical and effective strategy to prevent or lower the risk of oxidative stress-related diseases. Until now, most research has focused on electrophilic indirect Nrf2 activators, but the risk of 'off-target' effects may be associated with these activators. To find novel small non-electrophilic modulators of Nrf2, we started from chemical agents derived from a connectivity map (cMap) and identified 22 non-electrophilic potential Nrf2-activating drugs through a drug repositioning tactic...
May 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28571976/reliability-of-the-diaphragmatic-compound-muscle-action-potential-evoked-by-cervical-magnetic-stimulation-and-recorded-via-chest-wall-surface-emg
#19
Joseph F Welch, Robyn L Mildren, Martin Zaback, Bruno Archiza, Grayson P Allen, A William Sheel
INTRODUCTION: Stimulation of the phrenic nerve via cervical magnetic stimulation (CMS) elicits a compound muscle action potential (CMAP) that allows for assessment of diaphragm activation. The reliability of CMS to evoke the CMAP recorded by chest wall surface EMG has yet to be comprehensively examined. METHODS: CMS was performed on healthy young males (n=10) and females (n=10). Surface EMG electrodes were placed on the right and left hemi-diaphragm between the 6-8th intercostal spaces...
September 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28557394/-age-related-changes-of-peripheral-nerve-system-and-muscles-of-the-limbs-in-healthy-persons
#20
V B Voitenkov, V N Komancev, N V Skripchenko, S G Grigoryev, A V Klimkin, A I Aksenova
Our aim was to present and analyze age-related changes of peripheral nerves and muscles of limbs on a huge population of healthy persons of different ages. Persons aged from 2 months to 87 years were studied by conduction studies (EMG) during the period 2009-2016 years in Scientific Research Institute of Children's Infection. Data of those 1 121confirmed healthy was included in our study. Conduction along n. Medianus, n. Ulnaris, n. Musculocutaneus, n. Axillaris, n. Facialis, n. Tibialis, n. Peroneus et n. Femoralis was registered, with latency and amplitude of compound muscle action potential (CMAP) being analyzed...
2017: Advances in Gerontology, Uspekhi Gerontologii
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