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https://www.readbyqxmd.com/read/29334308/neuromuscular-degenerative-effects-of-ankaferd-blood-stopper%C3%A2-in-mouse-sciatic-nerve-model
#1
Ramazan Üstün, Elif Kaval Oğuz, Çağrı Delilbaşı, Ayşe Şeker, Filiz Taşpınar, Mehmet Reşit Öncü, Ahmet Regaip Oğuz
Purpose Ankaferd Blood Stopper® (ABS), a licenced medicinal herbal extract, is commonly used as an effective topical haemostatic agent. This study is designed to investigate whether topical ABS application may cause peripheral nerve degeneration and neuromuscular dysfunction in a mouse sciatic nerve model. Methods Twenty mice were randomly divided into two groups; an ABS treated experimental group and a saline-treated control group. Left sciatic nerves were treated with 0.3 ml of ABS in the experimental group and 0...
January 15, 2018: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29325328/-value-of-split-hand-in-the-differential-diagnosis-of-amyotrophic-lateral-sclerosis-and-cervical-spondylotic-amyotrophy
#2
M Jiang, X Yan, L R Yan, Y B Zhan, H T Hu
Objective: To investigate the value of split hand in the differential diagnosis of amyotrophic lateral sclerosis(ALS) and cervical spondylotic amyotrophy (CSA). Methods: A total of 62 ALS patients, 57 CSA patients and 65 normal controls who visited the Neurology and Spine Department of Beijing Jishuitan Hospital from May 2013 to June 2017 were enrolled into this study.The amplitudes of compound muscle action potentials (CMAP) were recorded from abductor digiti minimi (ADM) and abductor pollicis brevis (APB)...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29315828/a-collagen-coated-pga-conduit-for-interpositional-jump-graft-with-end-to-side-neurorrhaphy-for-treating-facial-nerve-paralysis-in-rat
#3
Yosuke Niimi, Hajime Matsumine, Yuichi Takeuchi, Hironobu Osaki, Satoshi Tsunoda, Mariko Miyata, Masayuki Yamato, Hiroyuki Sakurai
PURPOSE: This study investigated the potential of collagen-coated polyglycolic acid (PGA) tube with interpositional jump graft (IPJG) in rat. MATERIALS AND METHODS: A total of 16 Lewis rats were used in this study. Facial nerve paralysis was created by ligating facial nerve trunk with a ligature clip. The rats were divided into 3 groups. Nerve conduit group (n = 6) were treated by IPJG with collagen-coated PGA tubes between the facial nerve trunks and the hypoglossal nerves...
January 8, 2018: Microsurgery
https://www.readbyqxmd.com/read/29305235/validation-of-isometric-tetanic-force-as-a-measure-of-muscle-recovery-after-nerve-injury-in-the-rabbit-biceps
#4
Kathleen M Kollitz, Guilherme Giusti, Patricia F Friedrich, Allen T Bishop, Alexander Y Shin
PURPOSE: The purpose of this study was to describe and validate a technique for measurement of isometric tetanic force (ITF) in the rabbit biceps muscle. MATERIALS AND METHODS: Eighteen New Zealand White rabbits were randomized to test either the right side or the left side first. Under propofol anesthesia, the brachial plexus and biceps brachii were exposed. The middle trunk (C6, C7) was secured in a bipolar electrode. Compound muscle action potential (CMAP) was measured...
January 3, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29294514/-electrophysiological-and-pathological-features-of-peripheral-nerve-in-rats-exposed-to-1-bromopropane
#5
Q H Du, W J Chen, T Li, D Y Sun
Objective: To study the electrophysiological changes and pathological characteristics of peripheral nerve in rats exposed to 1-bromopropane through chronic inhalation. Methods: 40 male SD rats were randomed divided into 4 groups, and exposed to 1-bromopropane vapor at concentrations of 1 000 mg/m(3), 2 000 mg/m(3), 4 000 mg/m(3) and fresh air respectively, 6 hours per day, 5 days per week for 12 weeks. The changes of nerve conduction velocity (NCV) , electromyography (EMG) and pathology were observed. Results: After 4 weeks of exposure, the body weights of high dose group are lower than that of the control group...
September 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29288990/diaphragm-motor-responses-to-phrenic-nerve-stimulation-in-als-surface-and-needle-recordings
#6
Mamede de Carvalho, Susana Pinto, Michael Swash
OBJECTIVE: In studies of phrenic nerve (PN) conduction in amyotrophic lateral sclerosis (ALS) both motor response amplitude and latency have been reported as abnormal. However, correlation with diaphragm motor unit loss, and with diaphragmatic function has not been fully evaluated. METHODS: We studied 83 patients with ALS, and 21 patients referred with clinically suspected phrenic nerve lesions whose studies were normal. PN responses elicited by percutaneous electrical stimulation in the neck were recorded using superficial electrodes placed at the surface markings of the diaphragm on the chest wall, and a concentric needle electrode inserted into the diaphragmatic costal fibres...
December 13, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29259352/mechanism-of-restoration-of-forelimb-motor-function-after-cervical-spinal-cord-hemisection-in-rats-electrophysiological-verification
#7
Takumi Takeuchi, Masahito Takahashi, Kazuhiko Satomi, Hideaki Ohne, Atsushi Hasegawa, Shunsuke Sato, Shoichi Ichimura
The objective of this study was to electrophysiologically assess the corticospinal tracts of adult rats and the recovery of motor function of their forelimbs after cervical cord hemisection. Of 39 adult rats used, compound muscle action potentials (CMAPs) of the forelimbs of 15 rats were evaluated, before they received left C5 segmental hemisection of the spinal cord, by stimulating the pyramid of the medulla oblongata on one side using an exciting microelectrode. All 15 rats exhibited contralateral electrical activity, but their CMAPs disappeared after hemisection...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/29239825/palpebral-portion-of-the-orbicularis-oculi-muscle-to-repetitive-nerve-stimulation-testing-a-potential-assessment-indicator-in-patients-with-generalized-myasthenia-gravis
#8
Chong Yan, Jie Song, Song Pang, Fangfang Yi, Jianying Xi, Lei Zhou, Ding Ding, Weifeng Wang, Kai Qiao, Chongbo Zhao
Repetitive nerve stimulation (RNS) is a valuable diagnostic method for myasthenia gravis (MG). However, its association with clinical severity was scarcely studied. We reviewed medical records and retrospectively enrolled 121 generalized MG patients. Sensitivity of different muscles to RNS and clinical scoring systems was evaluated. RNS testing revealed facial muscles have the highest positive rate, followed by proximal muscles and distal muscles, with the palpebral portion of the orbicularis oculi muscle most sensitive...
November 24, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29236601/optimal-reference-electrode-positioning-for-electroneurography-at-the-orbicularis-oculi-a-case-report-and-short-review
#9
Nobushige Takahashi, Osamu Takahashi, Ryosuke Ushijima, Rie Umebayashi, Junji Nishikawa
Electroneurography is one of the most useful tests for evaluating facial nerve function. Because many patients with peripheral facial palsy complain of difficulty with eye closure, recording compound muscle action potentials (CMAPs) of the orbicularis oculi (OC) is important. However, electromyographers often encounter OC CMAPs that have an initial positivity. In the present study, facial motor potentials of a healthy subject were recorded using an electrode on the acromion and electrical activities over the facial muscles were evaluated...
2017: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/29202483/pmp22-antisense-oligonucleotides-reverse-charcot-marie-tooth-disease-type-1a-features-in-rodent-models
#10
Hien Tran Zhao, Sagar Damle, Karli Ikeda-Lee, Steven Kuntz, Jian Li, Apoorva Mohan, Aneeza Kim, Gene Hung, Mark A Scheideler, Steven S Scherer, John Svaren, Eric E Swayze, Holly B Kordasiewicz
Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by duplication of peripheral myelin protein 22 (PMP22) and is the most common hereditary peripheral neuropathy. CMT1A is characterized by demyelination and axonal loss, which underlie slowed motor nerve conduction velocity (MNCV) and reduced compound muscle action potentials (CMAP) in patients. There is currently no known treatment for this disease. Here, we show that antisense oligonucleotides (ASOs) effectively suppress PMP22 mRNA in affected nerves in 2 murine CMT1A models...
December 4, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29201547/decremental-responses-in-patients-with-motor-neuron-disease
#11
Mohammed H Alanazy, Janka Hegedus, Chris White, Lawrence Korngut
Objective: Involvement of the neuromuscular junction (NMJ) in amyotrophic lateral sclerosis (ALS) has been reported and is increasingly recognized as an important pathophysiological aspect. The relationship between decrement and clinical measures for possible application as a biomarker has not been comprehensively explored. Methods: We performed routine repetitive nerve stimulation (RNS) of three nerves on patients with ALS. We captured measures of muscle strength, grip strength, fatigability, and calculated slow vital capacity (SVC) rates of change assessing for associations...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29195078/a-next-generation-connectivity-map-l1000-platform-and-the-first-1-000-000-profiles
#12
Aravind Subramanian, Rajiv Narayan, Steven M Corsello, David D Peck, Ted E Natoli, Xiaodong Lu, Joshua Gould, John F Davis, Andrew A Tubelli, Jacob K Asiedu, David L Lahr, Jodi E Hirschman, Zihan Liu, Melanie Donahue, Bina Julian, Mariya Khan, David Wadden, Ian C Smith, Daniel Lam, Arthur Liberzon, Courtney Toder, Mukta Bagul, Marek Orzechowski, Oana M Enache, Federica Piccioni, Sarah A Johnson, Nicholas J Lyons, Alice H Berger, Alykhan F Shamji, Angela N Brooks, Anita Vrcic, Corey Flynn, Jacqueline Rosains, David Y Takeda, Roger Hu, Desiree Davison, Justin Lamb, Kristin Ardlie, Larson Hogstrom, Peyton Greenside, Nathanael S Gray, Paul A Clemons, Serena Silver, Xiaoyun Wu, Wen-Ning Zhao, Willis Read-Button, Xiaohua Wu, Stephen J Haggarty, Lucienne V Ronco, Jesse S Boehm, Stuart L Schreiber, John G Doench, Joshua A Bittker, David E Root, Bang Wong, Todd R Golub
We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures. Here, we report more than a 1,000-fold scale-up of the CMap as part of the NIH LINCS Consortium, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that we term L1000. We show that L1000 is highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts...
November 30, 2017: Cell
https://www.readbyqxmd.com/read/29194609/using-the-connectivity-map-to-discover-compounds-influencing-human-osteoblast-differentiation
#13
A M Brum, J van de Peppel, L Nguyen, A Aliev, M Schreuders-Koedam, T V Gajadien, C S van der Leije, A van Kerkwijk, M Eijken, J P T M van Leeuwen, B C J van der Eerden
Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. Identification of factors influencing osteoblast differentiation and bone formation is very important. Previously, we identified parbendazole to be a novel compound that stimulates osteogenic differentiation of human mesenchymal stromal cells (hMSCs), using gene expression profiling and bioinformatic analyses, including the Connectivity Map (CMap), as an in-silico approach...
December 1, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29192065/peripheral-nerve-function-estimation-by-linear-model-of-multi-cmap-responses-for-surgical-intervention-in-acoustic-neuroma-surgery
#14
Dilok Puanhvuan, Sorayouth Chumnanvej, Yodchanan Wongsawat
Nerve function assessments are crucial for surgical intervention during acoustic neuroma surgery. Cranial nerves such as acoustic and facial nerves, can be possibly damaged during tumor dissection. Proper surgical intervention should prevent neurological deficit and achieve total tumor removal. Conventionally, nerve function is qualitatively evaluated by surgeon and neurologist. Facial nerves can be preserved by monitoring the compound muscle action potential (CMAP) response. The differences in the amplitude and latency of CMAP are used as indicators during surgical interventions...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29190685/evaluation-of-rnai-and-crispr-technologies-by-large-scale-gene-expression-profiling-in-the-connectivity-map
#15
Ian Smith, Peyton G Greenside, Ted Natoli, David L Lahr, David Wadden, Itay Tirosh, Rajiv Narayan, David E Root, Todd R Golub, Aravind Subramanian, John G Doench
The application of RNA interference (RNAi) to mammalian cells has provided the means to perform phenotypic screens to determine the functions of genes. Although RNAi has revolutionized loss-of-function genetic experiments, it has been difficult to systematically assess the prevalence and consequences of off-target effects. The Connectivity Map (CMAP) represents an unprecedented resource to study the gene expression consequences of expressing short hairpin RNAs (shRNAs). Analysis of signatures for over 13,000 shRNAs applied in 9 cell lines revealed that microRNA (miRNA)-like off-target effects of RNAi are far stronger and more pervasive than generally appreciated...
November 30, 2017: PLoS Biology
https://www.readbyqxmd.com/read/29174541/engineered-multivalent-sensors-to-detect-coexisting-histone-modifications-in-living-stem-cells
#16
Aurore M-F Delachat, Nora Guidotti, Andreas L Bachmann, Antonio C A Meireles-Filho, Horst Pick, Carolin C Lechner, Cédric Deluz, Bart Deplancke, David M Suter, Beat Fierz
The regulation of fundamental processes such as gene expression or cell differentiation involves chromatin states, demarcated by combinatorial histone post-translational modification (PTM) patterns. The subnuclear organization and dynamics of chromatin states is not well understood, as tools for their detection and modulation in live cells are lacking. Here, we report the development of genetically encoded chromatin-sensing multivalent probes, cMAPs, selective for bivalent chromatin, a PTM pattern associated with pluripotency in embryonic stem cells (ESCs)...
November 21, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29156785/in-silico-and-in-vitro-identification-of-inhibitory-activities-of-sorafenib-on-histone-deacetylases-in-hepatocellular-carcinoma-cells
#17
Tsang-Pai Liu, Yi-Han Hong, Pei-Ming Yang
Although sorafenib has been approved for treating hepatocellular carcinoma (HCC), clinical results are not satisfactory. Polypharmacology (one drug with multiple molecular targets) is viewed as an attractive strategy for identifying novel mechanisms of a drug and then rationally designing more-effective next-generation therapeutic agents. In this study, a polypharmacological study of sorafenib was performed by mining the next-generation Connectivity Map (CMap) database, CLUE (https://clue.io/). We found that sorafenib may act as a histone deacetylase (HDAC) inhibitor based on similar gene expression profiles...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29150079/mechanism-hypotheses-for-the-electrophysiological-manifestations-of-two-cases-of-endplate-acetylcholinesterase-deficiency-related-congenital-myasthenic-syndrome
#18
Qingyun Ding, Dongchao Shen, Yi Dai, Youfang Hu, Yuzhou Guan, Mingsheng Liu, Liying Cui
OBJECTIVE: To summarize the electrophysiological characteristics of two cases of endplate acetylcholinesterase deficiency (EAD) related congenital myasthenic syndrome (CMS) caused by COLQ mutation and to discuss the possible mechanism of these electrophysiological phenomena. METHODS: Electrophysiological examinations were conducted including nerve conduction studies, routine electromyography (EMG), repetitive nerve stimulation (RNS) and single fiber EMG (SFEMG)...
November 14, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29149772/natural-history-of-infantile-onset-spinal-muscular-atrophy
#19
Stephen J Kolb, Christopher S Coffey, Jon W Yankey, Kristin Krosschell, W David Arnold, Seward B Rutkove, Kathryn J Swoboda, Sandra P Reyna, Ai Sakonju, Basil T Darras, Richard Shell, Nancy Kuntz, Diana Castro, Julie Parsons, Anne M Connolly, Claudia A Chiriboga, Craig McDonald, W Bryan Burnette, Klaus Werner, Mathula Thangarajh, Perry B Shieh, Erika Finanger, Merit E Cudkowicz, Michelle M McGovern, D Elizabeth McNeil, Richard Finkel, Susan T Iannaccone, Edward Kaye, Allison Kingsley, Samantha R Renusch, Vicki L McGovern, Xueqian Wang, Phillip G Zaworski, Thomas W Prior, Arthur H M Burghes, Amy Bartlett, John T Kissel
OBJECTIVE: Infantile-onset spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality, typically resulting in death prior to age 2. Clinical trials in this population require an understanding of disease progression and identification of meaningful biomarkers to hasten therapeutic development and predict outcomes. METHODS: A longitudinal, multi-center, prospective natural history study enrolled 26 SMA infants, and 27 control infants less than six months of age...
November 17, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29128986/longitudinal-neurophysiological-assessment-of-intramuscular-type-a-botulin-toxin-in-healthy-humans
#20
L Lispi, L Leonardi, A Petrucci
The aim of this study is to assess the neurophysiological abnormalities of type A botulin toxin-infiltrated human muscle, and their evolution over time. Seried cMAP measurements, 3 and 20 Hz repetitive nerve stimulation, EMG, SFEMG over 3 months from toxin injection. Our findings consist in lack of decrement with 3 Hz repetitive nerve stimulation and facilitation with 20 Hz repetitive nerve stimulation; progressive increasing of jitter; early appearance of fibrillations; small and short motor unit action potential in the first 3 weeks, followed by increasing of MUAP amplitude and duration, with polyphasic morphology...
November 11, 2017: Neurological Sciences
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