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https://www.readbyqxmd.com/read/28161089/are-electrophysiological-features-related-to-disability-in-patients-with-anti-mag-neuropathy
#1
Aude Gesquière-Dando, Emilien Delmont, Mael Launay, Jose Boucraut, Sharham Attarian
OBJECTIVES: To explore clinical-neurophysiological correlations in anti-myelin-associated glycoprotein (anti-MAG) neuropathy. METHODS: Clinical and electrophysiological data of 42 patients with anti-MAG neuropathy were retrospectively analysed. Disability was evaluated using the Overall Neuropathy Limitation Scale (ONLS), motor impairment through MRC sum score and sensory deficiency through INCAT sensory score. Compound motor action potential (CMAP) sum score was calculated adding the distal CMAP amplitude of the median, ulnar, tibial and fibular nerves of both sides...
February 1, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28153715/neuromuscular-excitability-changes-produced-by-sustained-voluntary-contraction-and-response-to-mexiletine-in-myotonia-congenita
#2
Federica Ginanneschi, Andrea Mignarri, Sabrina Lucchiari, Gianna Ulzi, Giacomo P Comi, Alessandro Rossi, Maria Teresa Dotti
OBJECTIVE: To investigate the cause of transient weakness in myotonia congenita (MC) and the mechanism of action of mexiletine in reducing weakness. METHODS: The changes in neuromuscular excitability produced by 1min of maximal voluntary contractions (MVC) were measured on the amplitude of compound muscle action potentials (CMAP) in two patients with either recessive or dominant MC, compared to control values obtained in 20 healthy subjects. Measurements were performed again in MC patients after mexiletine therapy...
January 30, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28150521/drug-repurposing-and-therapeutic-anti-microrna-predictions-for-inhibition-of-oxidized-low-density-lipoprotein-induced-vascular-smooth-muscle-cell-associated-diseases
#3
Shun-Tsung Chen, Chien-Hung Huang, Victor C Kok, Chi-Ying F Huang, Jin-Shuei Ciou, Jeffrey J P Tsai, Nilubon Kurubanjerdjit, Ka-Lok Ng
Drug repurposing is a new method for disease treatments, which accelerates the identification of new uses for existing drugs with minimal side effects for patients. MicroRNA-based therapeutics are a class of drugs that have been used in gene therapy following the FDA's approval of the first anti-sense therapy. This study examines the effects of oxLDL on vascular smooth muscle cells (VSMCs) and identifies potential drugs and antimiRs for treating VSMC-associated diseases. The Connectivity Map (cMap) database is utilized to identify potential new uses of existing drugs...
December 22, 2016: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28139721/therapeutic-properties-of-scutellaria-baicalensis-in-db-db-mice-evaluated-using-connectivity-map-and-network-pharmacology
#4
Bu-Yeo Kim, Kwang Hoon Song, Chi-Yeon Lim, Su-In Cho
We have reported that an extract of Scutellaria baicalensis (ESB) has effects against obesity and hypertriglyceridemia in type 2 diabetic animal model (db/db mouse). In the present study, we tried to explain the pharmacological effects of ESB by integrating gene expression information from db/db mouse liver with that of ESB-treated HepG2 hepatocellular carcinoma cells. Using Connectivity Map (cmap) analysis, we found an inverse relationship in the pharmaceutical profiles based on gene expression between db/db mouse liver and ESB-treated HepG2 cells...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28139516/effects-of-head-down-tilt-on-nerve-conduction-in-rhesus-monkeys
#5
Bo Sun, Xiao-Yun Zhang, Li-Zhi Liu, Zhao-Hui Chen, Zhong-Quan Dai, Xu-Sheng Huang
BACKGROUND: Few studies have focused on peripheral nerve conduction during exposure to microgravity. The -6° head-down tilt (HDT) comprises an experimental model used to simulate the space flight environment. This study investigated nerve conduction characteristics of rhesus monkeys before and after prolonged exposure to HDT. METHODS: Six rhesus monkeys (3-4 years old) were tilted backward 6° from the horizontal. Nerve conduction studies (NCSs) were performed on the median, ulnar, tibial, and fibular motor nerves...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28132610/upper-limb-recovery-in-spinal-cord-injury
#6
Jens A Petersen, Martina Spiess, Armin Curt, Norbert Weidner, Rüdiger Rupp, Rainer Abel, Martin Schubert
BACKGROUND AND OBJECTIVE: The course of central and peripheral motor recovery after cervical spinal cord injury (SCI) may be investigated by electrophysiological measures. The goal of this study was to compare the 2 over the first year after injury in relation to motor gains. METHODS: Compound motor action potentials (CMAPs), motor-evoked potentials (MEPs), and F-waves were recorded from the abductor digiti minimi and CMAP and F-waves from abductor hallucis muscles in 305 patients at about 15 days, 1 month, 3 months, 6 months, and 12 months following an acute traumatic SCI...
January 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28069634/a-review-of-connectivity-map-and-computational-approaches-in-pharmacogenomics
#7
Aliyu Musa, Laleh Soltan Ghoraie, Shu-Dong Zhang, Galina Galzko, Olli Yli-Harja, Matthias Dehmer, Benjamin Haibe-Kains, Frank Emmert-Streib
Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast to classical pharmacology focusing at one target at a time, the transcriptomics profiles provided by CMap and LINCS open the door for systems biology approaches on the pathway and network level. In this article, we provide a review of recent developments in computational pharmacogenomics with respect to CMap and LINCS and related applications...
January 9, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28068522/motor-evoked-potential-gain-is-a-helpful-test-for-the-detection-of-corticospinal-tract-dysfunction-in-amyotrophic-lateral-sclerosis
#8
Y Duclos, A M Grapperon, E Jouve, R Truillet, C Zemmour, A Verschueren, J Pouget, S Attarian
OBJECTIVE: The detection of upper motor neuron (UMN) dysfunction is necessary for the diagnosis of amyotrophic lateral sclerosis (ALS). However, signs of UMN dysfunction may be difficult to establish. This study aimed to determine whether motor-evoked potential (MEP) gain (MEP area/background electromyographic activity) represents an efficient alternative to assess UMN dysfunction. METHODS: MEP area, MEP/compound muscle action potential (CMAP) area ratio, and MEP gain were tested at different force levels in healthy control subjects and ALS patients...
February 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28058586/key-genes-in-stomach-adenocarcinoma-identified-via-network-analysis-of-rna-seq-data
#9
Li Shen, Lizhi Zhao, Jiquan Tang, Zhiwei Wang, Weisong Bai, Feng Zhang, Shouli Wang, Weihua Li
RNA-seq data of stomach adenocarcinoma (STAD) were analyzed to identify critical genes in STAD. Meanwhile, relevant small molecule drugs, transcription factors (TFs) and microRNAs (miRNAs) were also investigated. Gene expression data of STAD were downloaded from The Cancer Genome Atlas (TCGA). Differential analysis was performed with package edgeR. Relationships with correlation coefficient > 0.6 were retained in the gene co-expression network. Functional enrichment analysis was performed for the genes in the network with DAVID and KOBASS 2...
January 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28052373/best-time-window-for-the-use-of-calcium-modulating-agents-to-improve-functional-recovery-in-injured-peripheral-nerves-an-experiment-in-rats
#10
Yuhui Yan, Feng-Yi Shen, Michael Agresti, Lin-Ling Zhang, Hani S Matloub, John A LoGiudice, Robert Havlik, Jifeng Li, Yu-Dong Gu, Ji-Geng Yan
Peripheral nerve injury can have a devastating effect on daily life. Calcium concentrations in nerve fibers drastically increase after nerve injury, and this activates downstream processes leading to neuron death. Our previous studies showed that calcium-modulating agents decrease calcium accumulation, which aids in regeneration of injured peripheral nerves; however, the optimal therapeutic window for this application has not yet been identified. In this study, we show that calcium clearance after nerve injury is positively correlated with functional recovery in rats suffering from a crushed sciatic nerve injury...
January 4, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28043769/motor-unit-number-index-munix-detects-motor-neuron-loss-in-pre-symptomatic-muscles-in-amyotrophic-lateral-sclerosis
#11
Christoph Neuwirth, Paul E Barkhaus, Christian Burkhardt, José Castro, David Czell, Mamede de Carvalho, Sanjeev Nandedkar, Erik Stålberg, Markus Weber
OBJECTIVE: Motor Unit Number Index (MUNIX) is a quantitative neurophysiological measure that provides an index of the number of lower motor neurons supplying a muscle. It reflects the loss of motor neurons in patients with Amyotrophic Lateral Sclerosis (ALS). However, it is unclear whether MUNIX also detects motor unit loss in strong, non-wasted muscles. METHODS: Three centres measured MUNIX in 49 ALS patients every three months in six different muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis, abductor hallucis) on the less affected side...
December 18, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28024449/effects-of-different-force-fields-on-the-structural-character-of-%C3%AE-synuclein-%C3%AE-hairpin-peptide-35-56-in-aqueous-environment
#12
Sangeeta Kundu
The hallmark of Parkinson's disease (PD) is the intracellular protein aggregation forming Lewy Bodies (LB) and Lewy neuritis which comprise mostly of a protein, alpha synuclein (α-syn). Molecular dynamics (MD) simulation methods can augment experimental techniques to understand misfolding and aggregation pathways with atomistic resolution. The quality of MD simulations for proteins and peptides depends greatly on the accuracy of empirical force fields. The aim of this work is to investigate the effects of different force fields on the structural character of β hairpin fragment of α-syn (residues 35-56) peptide in aqueous solution...
December 26, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28017534/direct-motor-evoked-potentials-and-cortical-mapping-using-the-nim%C3%A2-nerve-monitoring-system-a-technical-note
#13
Suparna Bharadwaj, Faizal Haji, Matthew Hebb, Jason Chui
Motor evoked potentials (MEPs) are commonly used to prevent neurological injury when operating in close proximity to the motor cortex or corticospinal pathway. We report a novel application of the NIM® nerve monitoring system (Medtronic@ NIM response 3.0) for intraoperative direct cortical (dc)-MEPs monitoring. A 69-year-old female patient presented with a 4month history of progressive left hemiparesis resulting from a large right sided posterior frontal meningioma that abutted and compressed the motor cortex...
December 22, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28017171/perineural-dexmedetomidine-effects-on-sciatic-nerve-in-rat
#14
Abdulkadir Yektaş, Murat Çabalar, Mehmet Sar, Ayşin Alagöl, Duygu Sultan Çelik, Vildan Yayla, Deniz Tolga
The present study was designed to test the hypothesis that high dose dexmedetomidine would increase the duration of antinociception to a thermal stimulus in a rat model of sciatic nerve blockade without causing nerve damage. The rats were anesthetized with isoflurane. After electromyography (EMG) recordings, right sciatic nerves were explored and perineural injections were delivered: Group D (n=7), 40μgμgkg(-1) dexmedetomidine administration, Group II (n=6), (0.2mL) saline administration, Group III (n=2), only surgically exploration of the right sciatic nevre...
January 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/27997686/electrophysiological-and-neuromuscular-stability-of-persons-with-chronic-inflammatory-demyelinating-polyneuropathy-cidp
#15
Kevin J Gilmore, Matti D Allen, Timothy J Doherty, Kurt Kimpinski, Charles L Rice
OBJECTIVE: We assessed motor unit (MU) properties and neuromuscular stability in the tibialis anterior (TA) of CIDP patients using decomposition-based quantitative electromyography (DQEMG). METHODS: Dorsiflexion strength was assessed, and surface and concentric needle electromyography (EMG) were sampled from the TA. Estimates of MU numbers were derived using DQEMG and spike-triggered averaging. Neuromuscular transmission stability was assessed from concentric needle-detected motor unit potentials (MUPs)...
December 20, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27988478/monitoring-the-short-term-effect-of-intravenous-immunoglobulins-in-multifocal-motor-neuropathy-using-motor-unit-number-index
#16
Manon Philibert, Aude-Marie Grapperon, Emilien Delmont, Shahram Attarian
OBJECTIVE: To determine whether motor unit number index (MUNIX) is pertinent to monitor the effect of intravenous immunoglobulins (IVIg) in multifocal motor neuropathy (MMN). METHODS: MUNIX was assessed longitudinally in 7 MMN patients and 17 healthy controls in the abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles. A MUNIX sum-score and a compound muscle action potential (CMAP) sum-score were calculated by summing up the scores of APB and ADM...
January 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27940046/electrical-impedance-myography-for-discriminating-traumatic-peripheral-nerve-injury-in-the-upper-extremity
#17
Zhao Li, Dong Tian, Lingfen Chen, Xiaoqing Wang, Lijuan Jiang, Yude Yu
OBJECTIVE: To evaluate the potential of electrical impedance myography (EIM), which is sensitive to the changes in muscle structure and physiology, in discriminating traumatic peripheral nerve injury (TPNI) in the upper extremity. To identify factors that primarily influence muscle atrophy secondary to nerve injury. METHODS: Thirty-nine patients with TPNI underwent EIM measurement and standard electromyography tests for multiple muscles in the upper extremity. The side-to-side differences in EIM parameters were calculated for each subject and compared with the compound motor action potential (CMAP) amplitude, which is a measure of injury severity, and the time since injury...
February 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27935072/physical-exercise-in-myasthenia-gravis-is-safe-and-improves-neuromuscular-parameters-and-physical-performance-based-measures-a-pilot-study
#18
Elisabet Westerberg, Carl Johan Molin, Ida Lindblad, Margareta Emtner, Anna Rostedt Punga
INTRODUCTION: Due to the shortage of exercise-related research in Myasthenia Gravis (MG), there are no consensus guidelines on physical exercise for MG patients. METHODS: In this prospective pilot study, 10 MG patients with mild disease performed supervised aerobic and resistance training twice weekly for 12 weeks. The Myasthenia Gravis Composite (MGC) score, compound motor action potential (CMAP), repetitive nerve stimulation, muscle force, physical performance-based measures, serum levels of interleukin-6, muscle enzymes as well as immuno-microRNAs miR-150-5p and miR-21-5p were assessed before and after the training period...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27935068/single-fiber-emg-with-concentric-electrodes-in-lambert-eaton-myasthenia
#19
Yuzhou Guan, Qingyun Ding, Mingsheng Liu, Jingwen Niu, Liying Cui
INTRODUCTION: We analyzed jitter recordings made with concentric needle electrode single-fiber EMG (CNE-SFEMG) in Lambert-Eaton myasthenia (LEM). METHODS: Fifteen subjects diagnosed with LEM were studied using CNE-SFEMG in the extensor digitorum (ED) and tibialis anterior (TA) muscles. CNE-SFEMG in the ED and TA was also used to evaluate 12 and 10 healthy controls (HCs), respectively. RESULTS: Ten men and 5 women were diagnosed with LEM based on an increase of 100% in compound muscle action potential (CMAP) amplitude during 50 Hz repetitive nerve stimulation...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27930419/repetitive-facial-nerve-stimulation-using-occipitalis-muscle
#20
Turgut Adatepe, Ayşegül Gündüz, Ahmet Yldrm, Nurten Uzun
INTRODUCTION: We aimed to evaluate the reliability and reproducibility of repetitive nerve stimulation (RNS) recorded on occipitalis muscle by comparing recordings on nasalis muscle in healthy subjects. SUBJECTS: and methods: A total of 23 healthy subjects (mean age: 44.7±13.8 years) underwent detailed neurological examination and RNS using nasalis and occipitalis muscles. Amplitude and area percentage changes of CMAPs after RNS with different frequency were compared between right and left-sides and between recordings on nasalis and occipitalis muscles...
December 3, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
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