keyword
MENU ▼
Read by QxMD icon Read
search

Connectivity map

keyword
https://www.readbyqxmd.com/read/28325027/identifying-the-effects-of-visceral-interoception-on-human-brain-connectome-a-multivariate-analysis-of-covariance-of-fmri-data
#1
Behnaz Jarrahi, Dante Mantini
Sources of variations in the neural circuitry of the human brain and interrelationship between intrinsic connectivity networks (ICNs) are still a matter of debate and ongoing research. Here, we applied a multivariate analysis of covariance (MANCOVA) based on high-dimensional independent component analysis (ICA) to identify the effects of interoception and related variables on human brain connectome. Fifteen healthy right-handed subjects (all females, age range 21 - 48 years; mean age = 30.3, SD = 8.7 years) underwent a blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) that included continuous intravesical saline infusion and drainage...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28318347/teratogenic-hazard-of-bpei-coated-silver-nanoparticles-to-xenopus-laevis
#2
Anita Colombo, Melissa Saibene, Elisa Moschini, Patrizia Bonfanti, Maddalena Collini, Kaja Kasemets, Paride Mantecca
Silver nanoparticles (AgNPs) are among the most exploited antimicrobial agents and are used in many consumer products. Size and surface reactivity are critical physico-chemical properties responsible for NPs toxicity, and surface coatings, often used to functionalize or stabilize AgNPs, can influence their toxic profile and biocompatibility. In the current study the developmental toxicity of 1) negatively charged citrate-coated AgNPs (Cit-AgNPs), 2) positively charged branched polyethylenimine-coated AgNPs (BPEI-AgNPs), and 3) Ag(+) (from 0...
March 20, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28316236/webmolcs-a-web-based-interface-for-visualizing-molecules-in-3d-chemical-spaces
#3
Mahendra Awale, Daniel Probst, Jean-Louis Reymond
The concept of chemical space provides a convenient framework to analyze large collections of molecules by placing them in property spaces where distances represent similarities. Here we report webMolCS, a new type of web-based interface visualizing up to 5000 user-defined molecules in six different 3D chemical spaces obtained by principal component analysis or similarity mapping of multi-dimensional property spaces describing composition (MQN: 42D Molecular Quantum Numbers, SMIfp: 34D SMILES fingerprint), shapes and pharmacophores (APfp: 20D atom pair fingerprint, Xfp: 55D category extended atom pair fingerprint), and substructures (Sfp: 1024D binary substructure fingerprint, ECfp4: 1024D extended connectivity fingerprint)...
March 19, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28315521/systematic-morphological-profiling-of-human-gene-and-allele-function-via-cell-painting
#4
Mohammad Hossein Rohban, Shantanu Singh, Xiaoyun Wu, Julia B Berthet, Mark-Anthony Bray, Yashaswi Shrestha, Xaralabos Varelas, Jesse S Boehm, Anne E Carpenter
We hypothesized that human genes and disease-associated alleles might be systematically functionally annotated using morphological profiling of cDNA constructs, via a microscopy-based Cell Painting assay. Indeed, 50% of the 220 tested genes yielded detectable morphological profiles, which grouped into biologically meaningful gene clusters consistent with known functional annotation (e.g., the RAS-RAF-MEK-ERK cascade). We used novel subpopulation-based visualization methods to interpret the morphological changes for specific clusters...
March 18, 2017: ELife
https://www.readbyqxmd.com/read/28315038/the-mirror-neuron-system-in-relapsing-remitting-multiple-sclerosis-patients-with-low-disability
#5
Julio Plata-Bello, Yaiza Pérez-Martín, Abril Castañón-Pérez, Cristián Modroño, Helga Fariña, Estefanía Hernández-Martín, Montserrat González-Platas, Francisco Marcano, José Luis González-Mora
To study the visuospatial/visuoperceptive function using a mirror neuron system (MNS) based approach in multiple sclerosis (MS) patients and a healthy control group. Two task-based fMRIs (an execution task and an observation task) and one resting-fMRI were performed in a group of MS patients (n = 24) and a group of healthy controls (n = 15). The execution and observation tasks consisted of the performance or observation of the index-thumb opposition task. Statistical parametric mapping approaches were used to identify differences in the brain activity and functional connectivity (FC) of the MNS between MS patients and healthy controls...
March 17, 2017: Brain Topography
https://www.readbyqxmd.com/read/28304298/exercise-training-and-functional-connectivity-changes-in-mild-cognitive-impairment-and-healthy-elders
#6
Theresa J Chirles, Katherine Reiter, Lauren R Weiss, Alfonso J Alfini, Kristy A Nielson, J Carson Smith
BACKGROUND: Effective interventions are needed to improve brain function in mild cognitive impairment (MCI), an early stage of Alzheimer's disease (AD). The posterior cingulate cortex (PCC)/precuneus is a hub of the default mode network (DMN) and is preferentially vulnerable to disruption of functional connectivity in MCI and AD. OBJECTIVE: We investigated whether 12 weeks of aerobic exercise could enhance functional connectivity of the PCC/precuneus in MCI and healthy elders...
March 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28304284/scanning-gate-microscopy-of-magnetic-focusing-in-graphene-devices-quantum-vs-classical-simulation
#7
Marko D Petrović, Slaviša Milovanović, Francois Peeters
We compare classical versus quantum electron transport in recently investigated magnetic focusing devices [S. Bhandari et al., Nano Lett. 16, 1690 (2016)] exposed to the perturbing potential of a scanning gate microscope (SGM). Using the Landauer-Büttiker formalism for a multi-terminal device, we calculate resistance maps that are obtained as the SGM tip is scanned over the sample. There are three unique regimes in which the scanning tip can operate (focusing, repelling, and mixed regime) which are investigated...
March 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28303031/a-biologically-validated-hcv-e1e2-heterodimer-structural-model
#8
Matteo Castelli, Nicola Clementi, Jennifer Pfaff, Giuseppe A Sautto, Roberta A Diotti, Roberto Burioni, Benjamin J Doranz, Matteo Dal Peraro, Massimo Clementi, Nicasio Mancini
The design of vaccine strategies and the development of drugs targeting the early stages of Hepatitis C virus (HCV) infection are hampered by the lack of structural information about its surface glycoproteins E1 and E2, the two constituents of HCV entry machinery. Despite the recent crystal resolution of limited versions of both proteins in truncated form, a complete picture of the E1E2 complex is still missing. Here we combined deep computational analysis of E1E2 secondary, tertiary and quaternary structure with functional and immunological mutational analysis across E1E2 in order to propose an in silico model for the ectodomain of the E1E2 heterodimer...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298886/mapping-and-analysis-of-the-connectome-of-sympathetic-premotor-neurons-in-the-rostral-ventrolateral-medulla-of-the-rat-using-a-volumetric-brain-atlas
#9
Bowen Dempsey, Sheng Le, Anita Turner, Phil Bokiniec, Radhika Ramadas, Jan G Bjaalie, Clement Menuet, Rachael Neve, Andrew M Allen, Ann K Goodchild, Simon McMullan
Spinally projecting neurons in the rostral ventrolateral medulla (RVLM) play a critical role in the generation of vasomotor sympathetic tone and are thought to receive convergent input from neurons at every level of the neuraxis; the factors that determine their ongoing activity remain unresolved. In this study we use a genetically restricted viral tracing strategy to definitively map their spatially diffuse connectome. We infected bulbospinal RVLM neurons with a recombinant rabies variant that drives reporter expression in monosynaptically connected input neurons and mapped their distribution using an MRI-based volumetric atlas and a novel image alignment and visualization tool that efficiently translates the positions of neurons captured in conventional photomicrographs to Cartesian coordinates...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28298427/systematic-protein-protein-interaction-mapping-for-clinically-relevant-human-gpcrs
#10
Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi-Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar
G-protein-coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR-mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two-hybrid (MYTH) approach and identified interacting partners for 48 selected full-length human ligand-unoccupied GPCRs in their native membrane environment...
March 15, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28297638/buckling-instabilities-and-complex-trajectories-in-a-simple-model-of-uniflagellar-bacteria
#11
Frank T M Nguyen, Michael D Graham
Observations of uniflagellar bacteria show that buckling instabilities of the hook protein connecting the cell body and flagellum play a role in locomotion. To understand this phenomenon, we develop models at varying levels of description with a particular focus on the parameter dependence of the buckling instability. A key dimensionless group called the flexibility number measures the hook flexibility relative to the thrust exerted by the flagellum; this parameter and the geometric parameters of the cell determine the stability of straight swimming...
March 14, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28295837/compromised-hippocampus-striatum-pathway-as-a-potential-imaging-biomarker-of-mild-traumatic-brain-injury-and-posttraumatic-stress-disorder
#12
D Rangaprakash, Gopikrishna Deshpande, Thomas A Daniel, Adam M Goodman, Jennifer L Robinson, Nouha Salibi, Jeffrey S Katz, Thomas S Denney, Michael N Dretsch
OBJECTIVES: Military service members risk acquiring posttraumatic stress disorder (PTSD) and mild-traumatic brain injury (mTBI), with high comorbidity. Owing to overlapping symptomatology in chronic mTBI or postconcussion syndrome (PCS) and PTSD, it is difficult to assess the etiology of a patient's condition without objective measures. Using resting-state functional MRI in a novel framework, we tested the hypothesis that their neural signatures are characterized by functionally hyperconnected brain regions which are less variable over time...
March 15, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28294457/structural-and-functional-brain-network-correlates-of-depressive-symptoms-in-premanifest-huntington-s-disease
#13
Peter McColgan, Adeel Razi, Sarah Gregory, Kiran K Seunarine, Alexandra Durr, Raymund A C Roos, Blair R Leavitt, Rachael I Scahill, Chris A Clark, Doug R Langbehn, Geraint Rees, Sarah J Tabrizi
Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub-network associated with depression was identified in a data-driven fashion and network-based statistics was used to investigate which specific connections correlated with depression scores...
March 15, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28294137/relationship-between-duration-of-untreated-psychosis-and-intrinsic-corticostriatal-connectivity-in-patients-with-early-phase-schizophrenia
#14
Deepak K Sarpal, Delbert G Robinson, Christina Fales, Todd Lencz, Miklos Argyelan, Katherine H Karlsgodt, Juan A Gallego, Majnu John, John M Kane, Philip R Szeszko, Anil K Malhotra
Patients with first-episode psychosis experience psychotic symptoms for a mean of up to two years prior to initiation of treatment, and long duration of untreated psychosis (DUP) is associated with poor clinical outcomes. Meanwhile, evidence compiled from numerous studies suggests that longer DUP is not associated with structural brain abnormalities. To date, few studies have examined the relationship between DUP and functional neuroimaging measures. In the present study, we used seed-based resting-state functional connectivity to examine the impact of DUP on corticostriatal circuitry...
March 15, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28293468/a-method-for-independent-component-graph-analysis-of-resting-state-fmri
#15
Demetrius Ribeiro de Paula, Erik Ziegler, Pubuditha M Abeyasinghe, Tushar K Das, Carlo Cavaliere, Marco Aiello, Lizette Heine, Carol di Perri, Athena Demertzi, Quentin Noirhomme, Vanessa Charland-Verville, Audrey Vanhaudenhuyse, Johan Stender, Francisco Gomez, Jean-Flory L Tshibanda, Steven Laureys, Adrian M Owen, Andrea Soddu
INTRODUCTION: Independent component analysis (ICA) has been extensively used for reducing task-free BOLD fMRI recordings into spatial maps and their associated time-courses. The spatially identified independent components can be considered as intrinsic connectivity networks (ICNs) of non-contiguous regions. To date, the spatial patterns of the networks have been analyzed with techniques developed for volumetric data. OBJECTIVE: Here, we detail a graph building technique that allows these ICNs to be analyzed with graph theory...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28290071/structural-connectivity-in-spatial-attention-network-reconstruction-from-left-hemispatial-neglect
#16
Takaaki Hattori, Kenji Ito, Chika Nakazawa, Yoshiyuki Numasawa, Mayumi Watanabe, Shigeki Aoki, Hidehiro Mizusawa, Sumio Ishiai, Takanori Yokota
Left hemispatial neglect (neglect) is an impaired state of spatial attention. We aimed to reconstruct structural connectivity in the spatial attention network and to identify disconnection patterns underlying neglect. We enrolled 59 right-handed patients who had their first-ever infarction in the right hemisphere and classified them into neglect group (34 patients with neglect) and control group (25 patients without neglect). The neglect group was further subcategorized into 6 subgroups based on infarcted vascular territories...
March 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28290051/construction-of-a-comprehensive-protein-protein-interaction-map-for-vitiligo-disease-to-identify-key-regulatory-elements-a-systemic-approach
#17
Anvita Gupta Malhotra, Mohit Jha, Sudha Singh, Khushhali M Pandey
Vitiligo is an idiopathic disorder characterized by depigmented patches on the skin due to progressive loss of melanocytes. Several genetic, immunological, and pathophysiological investigations have established vitiligo as a polygenetic disorder with multifactorial etiology. However, no definite model explaining the interplay between these causative factors has been established hitherto. Therefore, we studied the disorder at the system level to identify the key proteins involved by exploring their molecular connectivity in terms of topological parameters...
March 13, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28289262/uncertain-links-in-host-parasite-networks-lessons-for-parasite-transmission-in-a-multi-host-system
#18
Josephine G Walker, Michaela Plein, Eric R Morgan, Peter A Vesk
For many parasites, the full set of hosts that are susceptible to infection is not known, and this could lead to a bias in estimates of transmission. We used counts of individual adult parasites from historical parasitology studies in southern Africa to map a bipartite network of the nematode parasites of herbivore hosts that occur in Botswana. Bipartite networks are used in community ecology to represent interactions across trophic levels. We used a Bayesian hierarchical model to predict the full set of host-parasite interactions from existing data on parasitic gastrointestinal nematodes of wild and domestic ungulates given assumptions about the distribution of parasite counts within hosts, while accounting for the relative uncertainty of less sampled species...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28287432/a-biologically-based-computational-approach-to-drug-repurposing-for-anthrax-infection
#19
Jane P F Bai, Theodore Sakellaropoulos, Leonidas G Alexopoulos
Developing drugs to treat the toxic effects of lethal toxin (LT) and edema toxin (ET) produced by B. anthracis is of global interest. We utilized a computational approach to score 474 drugs/compounds for their ability to reverse the toxic effects of anthrax toxins. For each toxin or drug/compound, we constructed an activity network by using its differentially expressed genes, molecular targets, and protein interactions. Gene expression profiles of drugs were obtained from the Connectivity Map and those of anthrax toxins in human alveolar macrophages were obtained from the Gene Expression Omnibus...
March 10, 2017: Toxins
https://www.readbyqxmd.com/read/28287315/near-infrared-spectroscopy-and-geostatistical-analysis-for-modeling-spatial-distribution-of-analytical-constituents-in-bulk-animal-by-product-protein-meals
#20
José A Adame-Siles, Tom Fearn, José E Guerrero-Ginel, Ana Garrido-Varo, Francisco Maroto-Molina, Dolores Pérez-Marín
Control and inspection operations within the context of safety and quality assessment of bulk foods and feeds are not only of particular importance, they are also demanding challenges, given the complexity of food/feed production systems and the variability of product properties. Existing methodologies have a variety of limitations, such as high costs of implementation per sample or shortcomings in early detection of potential threats for human/animal health or quality deviations. Therefore, new proposals are required for the analysis of raw materials in situ in a more efficient and cost-effective manner...
March 2017: Applied Spectroscopy
keyword
keyword
44042
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"