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https://www.readbyqxmd.com/read/28821719/neural-physiological-and-behavioral-correlates-of-visuomotor-cognitive-load
#1
S M Hadi Hosseini, Jennifer L Bruno, Joseph M Baker, Andrew Gundran, Lene K Harbott, J Christian Gerdes, Allan L Reiss
Visuomotor ability is quite crucial for everyday functioning, particularly in driving and sports. While there is accumulating evidence regarding neural correlates of visuomotor transformation, less is known about the brain regions that accommodate visuomotor mapping under different cognitive demands. We concurrently measured cortical activity and pupillary response, using functional near infrared spectroscopy (fNIRS) and eye-tracking glasses, to examine the neural systems linked to pupil dilation under varying cognitive demands...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821662/visual-receptive-field-heterogeneity-and-functional-connectivity-of-adjacent-neurons-in-primate-fronto-parietal-association-cortices
#2
Pooja Viswanathan, Andreas Nieder
The basic organization principles of the primary visual cortex (V1) are commonly assumed to also hold in the association cortex such that neurons within a cortical column share functional connectivity patterns and represent the same region of the visual field. We mapped the visual receptive fields (RFs) of neurons recorded at the same electrode in the ventral intraparietal area (VIP) and the lateral prefrontal cortex (PFC) of rhesus monkeys. We report that the spatial characteristics of visual receptive fields between adjacent neurons differed considerably, with increasing heterogeneity from VIP to PFC...
August 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28821653/human-occipital-and-parietal-gaba-selectively-influence-visual-perception-of-orientation-and-size
#3
Chen Song, Kristian Sandberg, Lau Møller Andersen, Jakob Udby Blicher, Geraint Rees
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in human brain. GABA level varies substantially across individuals and this variability is associated with inter-individual differences in visual perception. However, it remains unclear whether the association between GABA level and visual perception reflects a general influence of visual inhibition, or whether GABA level of different cortical regions selectively influences perception of different visual features. To address this, we studied how GABA level in parietal and occipital cortices related to inter-individual differences in size, orientation, and brightness perception, in a group of healthy young male participants...
August 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28821520/preclinical-medical-students-understandings-of-academic-and-medical-professionalism-visual-analysis-of-mind-maps
#4
Janusz Janczukowicz, Charlotte E Rees
INTRODUCTION: Several studies have begun to explore medical students' understandings of professionalism generally and medical professionalism specifically. Despite espoused relationships between academic (AP) and medical professionalism (MP), previous research has not yet investigated students' conceptualisations of AP and MP and the relationships between the two. OBJECTIVES: The current study, based on innovative visual analysis of mind maps, therefore aims to contribute to the developing literature on how professionalism is understood...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28818088/assessment-of-the-effect-of-left-atrial-cryoablation-enhanced-by-ganglionated-plexi-ablation-in-the-treatment-of-atrial-fibrillation-in-patients-undergoing-open-heart-surgery
#5
Jiří Bárta, Radim Brát
BACKGROUND: The aim of our study was to investigate, whether enhancement of left atrial cryoablation by ablation of the autonomic nervous system of left atrium leads to influencing the outcomes of surgical treatment of atrial fibrillation in patients with structural heart disease undergoing open-heart surgery. METHODS: The observed patient file consisted of 100 patients, who have undergone a combined open-heart surgery at our department between July 2012 and December 2014...
August 17, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28817798/toward-a-wiring-diagram-understanding-of-appetite-control
#6
REVIEW
Mark L Andermann, Bradford B Lowell
Prior mouse genetic research has set the stage for a deep understanding of appetite regulation. This goal is now being realized through the use of recent technological advances, such as the ability to map connectivity between neurons, manipulate neural activity in real time, and measure neural activity during behavior. Indeed, major progress has been made with regard to meal-related gut control of appetite, arcuate nucleus-based hypothalamic circuits linking energy state to the motivational drive, hunger, and, finally, limbic and cognitive processes that bring about hunger-mediated increases in reward value and perception of food...
August 16, 2017: Neuron
https://www.readbyqxmd.com/read/28815589/tight-temporal-coupling-between-synaptic-rewiring-of-olfactory-glomeruli-and-the-emergence-of-odor-guided-behavior-in-xenopus-tadpoles
#7
Beatrice Terni, Paolo Pacciolla, Helena Masanas, Pau Gorostiza, Artur Llobet
Olfactory sensory neurons (OSNs) are chemoreceptors that establish excitatory synapses within glomeruli of the olfactory bulb. OSNs undergo continuous turnover throughout life, causing the constant replacement of their synaptic contacts. Using Xenopus tadpoles as an experimental system to investigate rewiring of glomerular connectivity, we show that novel OSN synapses can transfer information immediately after formation, mediating an olfactory-guided behavior. Tadpoles recover the ability to detect amino acids four days after bilateral olfactory nerve transection...
August 17, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28813643/multi-connection-pattern-analysis-decoding-the-representational-content-of-neural-communication
#8
Yuanning Li, R Mark Richardson, Avniel Singh Ghuman
The lack of multivariate methods for decoding the representational content of interregional neural communication has left it difficult to know what information is represented in distributed brain circuit interactions. Here we present Multi-Connection Pattern Analysis (MCPA), which works by learning mappings between the activity patterns of the populations as a factor of the information being processed. These maps are used to predict the activity from one neural population based on the activity from the other population...
August 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28812571/identifying-species-threat-hotspots-from-global-supply-chains
#9
Daniel Moran, Keiichiro Kanemoto
Identifying hotspots of species threat has been a successful approach for setting conservation priorities. One important challenge in conservation is that, in many hotspots, export industries continue to drive overexploitation. Conservation measures must consider not just the point of impact, but also the consumer demand that ultimately drives resource use. To understand which species threat hotspots are driven by which consumers, we have developed a new approach to link a set of biodiversity footprint accounts to the hotspots of threatened species on the IUCN Red List of Threatened Species...
January 4, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811635/majorana-charges-winding-numbers-and-chern-numbers-in-quantum-ising-models
#10
G Zhang, C Li, Z Song
Mapping a many-body state on a loop in parameter space is a simple way to characterize a quantum state. The connections of such a geometrical representation to the concepts of Chern number and Majorana zero mode are investigated based on a generalized quantum spin system with short and long-range interactions. We show that the topological invariants, the Chern numbers of corresponding Bloch band, is equivalent to the winding number in the auxiliary plane, which can be utilized to characterize the phase diagram...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810930/sex-differences-in-microrna-mrna-networks-examination-of-novel-epigenetic-programming-mechanisms-in-the-sexually-dimorphic-neonatal-hypothalamus
#11
Christopher P Morgan, Tracy L Bale
BACKGROUND: Sexual differentiation of the male brain, and specifically the stress circuitry in the hypothalamus, is primarily driven by estrogen exposure during the perinatal period. Surprisingly, this single hormone promotes diverse programs of sex-specific development that vary widely between different cell types and across the developing male brain. The complexity of this phenomenon suggests that additional layers of gene regulation, including microRNAs (miRNAs), must act downstream of estrogen to mediate this specificity...
August 15, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28809686/salient-region-detection-using-diffusion-process-on-a-2-layer-sparse-graph
#12
Li Zhou, Zhaohui Yang, Zongtan Zhou, Dewen Hu
Diffusion-based salient region detection has recently received intense research attention. In this paper, we present some effective improvements concerning two important aspects of diffusion-based methods: the construction of the diffusion matrix and the seed vector. First, we construct a 2-layer sparse graph, which is generated by connecting each node to its neighboring nodes and the most similar node that shares common boundaries with its neighboring nodes. Compared with the most frequently used 2-layer neighborhood graph, our graph not only effectively uses local spatial relationships, but also removes dissimilar redundant nodes...
August 11, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28808060/the-human-rna-binding-protein-and-e3-ligase-mex-3c-binds-the-mex-3-recognition-element-mre-motif-with-high-affinity
#13
Lingna Yang, Chongyuan Wang, Fudong Li, Jiahai Zhang, Anam Nayab, Jihui Wu, Yunyu Shi, Qingguo Gong
MEX-3 is a KH domain-containing RNA-binding protein, first identified as a translational repressor in Caenorhabditis elegans, while its four orthologs (MEX-3A-D) in human and mouse were subsequently found to have E3 ubiquitin ligase activity mediated by a RING domain and critical for RNA degradation. Current evidence implicates human MEX-3C in many essential biological processes and suggests a strong connection with immune diseases and carcinogenesis. The highly conserved dual KH domains in MEX-3 proteins enable RNA binding and are essential for the recognition of the 3' UTR and posttranscriptional regulation of MEX-3 target transcripts...
August 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28807953/developing-family-practice-to-respond-to-global-health-challenges-the-besrour-papers-a-series-on-the-state-of-family-medicine-in-the-world
#14
REVIEW
Neil Arya, Bruce Dahlman, Christine Gibson, David Ponka, Cynthia Haq, Katherine Rouleau, Stephanie Hansel
OBJECTIVE: To assess family medicine's role in developing strong, coordinated, community-based, integrated health care systems in low-resource settings globally. COMPOSITION OF THE COMMITTEE: A subgroup of the Besrour Centre of the College of Family Physicians of Canada developed connections with selected international colleagues with expertise in international family medicine practice, health systems and capacity building, and teaching to map family medicine globally and give a bird's eye view of family medicine internationally...
August 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28806613/automatic-blood-vessels-segmentation-based-on-different-retinal-maps-from-octa-scans
#15
Nabila Eladawi, Mohammed Elmogy, Omar Helmy, Ahmed Aboelfetouh, Alaa Riad, Harpal Sandhu, Shlomit Schaal, Ayman El-Baz
The retinal vascular network reflects the health of the retina, which is a useful diagnostic indicator of systemic vascular. Therefore, the segmentation of retinal blood vessels is a powerful method for diagnosing vascular diseases. This paper presents an automatic segmentation system for retinal blood vessels from Optical Coherence Tomography Angiography (OCTA) images. The system segments blood vessels from the superficial and deep retinal maps for normal and diabetic cases. Initially, we reduced the noise and improved the contrast of the OCTA images by using the Generalized Gauss-Markov random field (GGMRF) model...
August 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28805813/analysis-of-genome-wide-association-data-highlights-candidates-for-drug-repositioning-in-psychiatry
#16
Hon-Cheong So, Carlos Kwan-Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim, Pak-Chung Sham
Knowledge of psychiatric disease genetics has advanced rapidly during the past decade with the advent of genome-wide association studies (GWAS). However, less progress has been made in harnessing these data to reveal new therapies. Here we propose a framework for drug repositioning by comparing transcriptomes imputed from GWAS data with drug-induced gene expression profiles from the Connectivity Map database and apply this approach to seven psychiatric disorders. We found a number of repositioning candidates, many supported by preclinical or clinical evidence...
August 14, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28805500/chitin-receptor-mediated-activation-of-map-kinases-and-ros-production-in-rice-and-arabidopsis
#17
Tsutomu Kawasaki, Kenta Yamada, Satomi Yoshimura, Koji Yamaguchi
Rapid induction of plant immune responses is essential to inhibit colonization and invasion by pathogens. Plants can recognize pathogen-associated molecular patterns (PAMPs) including fungal chitin and bacterial flagellin using pattern-recognition receptors (PRRs), which trigger the intracellular activation of mitogen-activated protein kinase (MAPK) cascades and the production of reactive oxygen species (ROS). MAPK activation and ROS production play pivotal roles in the induction of robust immune responses...
August 14, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28804783/functional-corticostriatal-connection-topographies-predict-goal-directed-behaviour-in-humans
#18
Andre F Marquand, Koen V Haak, Christian F Beckmann
Anatomical tracing studies in non-human primates have suggested that corticostriatal connectivity is topographically organized: nearby locations in striatum are connected with nearby locations in cortex. The topographic organization of corticostriatal connectivity is thought to underpin many goal-directed behaviours, but these topographies have not been completely characterised in humans and their relationship to uniquely human behaviours remains to be fully determined. Instead, the dominant approach employs parcellations that cannot model the continuous nature of the topography, nor accommodate overlapping cortical projections in the striatum...
August 2017: Nature Human Behaviour
https://www.readbyqxmd.com/read/28804450/whole-brain-mapping-of-the-inputs-and-outputs-of-the-medial-part-of-the-olfactory-tubercle
#19
Zhijian Zhang, Hongruo Zhang, Pengjie Wen, Xutao Zhu, Li Wang, Qing Liu, Jie Wang, Xiaobin He, Huadong Wang, Fuqiang Xu
The medial part of the olfactory tubercle (OT) is a brain structure located at the interface of the reward and olfactory system. It is closely related to pheromone-rewards, natural reinforcement, addiction and many other behaviors. However, the structure of the anatomic circuitry of the medial part of the OT is still unclear. In the present study, the medial part of the OT was found to be highly connected with a wide range of brain areas with the help of the pseudorabies virus tracing tool. In order to further investigate the detailed connections for specific neurons, another tracing tool - rabies virus was utilized for D1R-cre and D2R-cre mice...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28804262/effects-of-boundary-conditions-on-bistable-behaviour-in-axisymmetrical-shallow-shells
#20
P M Sobota, K A Seffen
Multistable shells are thin-walled structures that have more than one stable state of self-stress. We consider isotropic axisymmetrical shallow shells of arbitrary polynomial shapes using a Föppl-von Kármán analytical model. By employing a Rayleigh-Ritz approach, we identify stable shapes from local minima in the strain energy formulation, and we formally characterize the level of influence of the boundary conditions on the critical geometry for achieving bistable inversion-an effect not directly answered in the literature...
July 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
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