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https://www.readbyqxmd.com/read/27860480/-the-braf-mutation-and-the-possibilities-of-uveal-melanoma-metastasing-prognostic-markers-identification
#1
K Horkovičová, J Markus, I Krčová, P Babál, D Kobzová, B Smolková
AIM: The aim is to assess the BRAF gene mutations in patients with posterior uveal melanoma. MATERIAL AND METHODS: Retrospective analysis of the group of patients with malignant melanoma of the uvea, who were indicated to enucleation between 1.1 2015 to 1.3.2016. We analyzed stage of uveal melanoma, volume, cell type and BRAF gene mutations. RESULTS: In clinical study of 20 patients after enucleation due to uveal melanoma at the Department of Ophthalmology in Bratislava, patient age was ranged from 22 to 89 years with a median of 62 years...
2016: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/27856029/optical-coherence-tomography-angiography-characteristics-of-iris-melanocytic-tumors
#2
Alison H Skalet, Yan Li, Chen D Lu, Yali Jia, ByungKun Lee, Lennart Husvogt, Andreas Maier, James G Fujimoto, Charles R Thomas, David Huang
PURPOSE: To evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions. DESIGN: Cross-sectional observational clinical study. PARTICIPANTS: Patients with iris lesions and healthy volunteers. METHODS: Eyes were imaged using OCTA systems operating at 1050- and 840-nm wavelengths. Three-dimensional OCTA scans were acquired. Iris melanoma patients treated with radiation therapy were imaged again after I-125 plaque brachytherapy at 6 and 18 months...
November 14, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27833435/taxonomic-review-of-new-world-tachyina-coleoptera-carabidae-descriptions-of-new-genera-subgenera-and-species-with-an-updated-key-to-the-subtribe-in-the-americas
#3
REVIEW
Olivia F Boyd, Terry L Erwin
The classification of the carabid subtribe Tachyina (Trechitae: Bembidiini) is reviewed in light of newly discovered diversity from Central and South America. Described herein are three new genera (Tachyxystagen. n., Stigmatachysgen. n., Nothoderisgen. n.), two new subgenera of Meotachys (Scolistichussubgen. n., Hylotachyssubgen. n.), and two new subgenera of Elaphropus (Ammotachyssubgen. n., Idiotachyssubgen. n.). Two names previously synonymized under Polyderis (Polyderidius Jeannel, 1962) and Elaphropus (Nototachys Alluaud, 1930) are elevated to generic and subgeneric status, respectively...
2016: ZooKeys
https://www.readbyqxmd.com/read/27815703/development-of-an-activity-disease-score-in-patients-with-uveitis-uvedai
#4
Esperanza Pato, Mª Auxiliadora Martin-Martinez, Adela Castelló, Rosalía Méndez-Fernandez, Santiago Muñoz-Fernández, Miguel Cordero-Coma, Lucia Martinez-Costa, Elia Valls, Miguel Reyes, Félix Francisco, Mar Esteban, Alex Fonollosa, Fernando Sanchez-Alonso, Cruz Fernández-Espartero, Teresa Diaz-Valle, José Miguel Carrasco, Emma Beltran-Catalán, Marisa Hernández-Garfella, María Victoria Hernández, Laura Pelegrin, Ricardo Blanco, David Diaz-Valle
To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable...
November 4, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27807580/primary-bile-duct-melanoma-causing-obstructive-jaundice
#5
Naga S Addepally, Jagpal S Klair, Keith Lai, Farshad Aduli, Mohit Girotra
Malignant melanoma is one of the few malignancies that are well known for unusual behavior. Primary malignant melanoma usually originates from squamous epithelium of skin, mucous membranes, retina, and uvea. Although melanoma can metastasize to any part of the body, including biliary tract, primary malignant melanoma of bile ducts is an extremely rare entity. We present a 52-year-old man who presented with 5-month epigastric pain and 15-pound weight loss, with 1-week duration of jaundice, nausea/vomiting, pale stools, and dark urine, blood work suggested cholestatic jaundice...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27792048/primary-gliosarcoma-of-the-optic-nerve-a-unique-adult-optic-pathway-glioma
#6
Patrick J Cimino, Yevgeniy V Sychev, Luis F Gonzalez-Cuyar, Raghu C Mudumbai, C Dirk Keene
A 90-year-old woman presented with 1-year history of right-sided progressive proptosis, neovascular glaucoma, blindness, and worsening ocular pain. No funduscopic examination was possible because of a corneal opacity. Head CT scan without contrast demonstrated a heterogeneous 4.1 cm (anterior-posterior) by 1.7 cm (transverse) cylindrical mass arising in the right optic nerve and extending from the retrobulbar globe to the optic canal. She underwent palliative enucleation with subtotal resection of the orbital optic nerve and tumor...
October 11, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27786310/s100a8-promotes-migration-and-infiltration-of-inflammatory-cells-in-acute-anterior-uveitis
#7
Yuqin Wang, Zuhui Zhang, Laihe Zhang, Xinxin Li, Rui Lu, Peipei Xu, Xuhong Zhang, Mali Dai, Xiaodan Dai, Jia Qu, Fan Lu, Zailong Chi
Uveitis, the pathologic condition of inflammation of the uvea, frequently leads to severe vision loss and blindness. S100A8 is a calcium-binding protein which mainly expresses in granulocytes and monocytes and plays a prominent role in the regulation of inflammatory processes and immune response. Here, we determined the role of S100A8-positive cells in acute anterior uveitis (AAU) and keratitis. In rat models of endotoxin (lipopolisaccharide, LPS) -induced uveitis (EIU) and keratitis, S100A8-positive granulocytes and monocytes increased significantly in the iris-ciliary body and cornea as well as in the blood...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27768224/acquired-ectropion-uveae-and-secondary-glaucoma-due-to-trauma-report-of-3-cases
#8
Vujica Markovic, Dragan Vukovic, Aleksandra Radosavljevic, Ivan Marjanovic
PURPOSE: To investigate the possible association between acquired ectropion uveae and blunt trauma to the eye. We present 3 cases of acquired ectropion uveae that occurred after blunt trauma to the eye. There are no previously published data on possible association of these conditions. METHODS: A retrospective review was conducted of patients with ectropion uveae and eye injury at University Eye Hospital over a 10-year period (2006-2016). We analyzed medical records and clinical findings...
October 21, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27759709/choroidal-sarcoid-granuloma-simulating-prostate-carcinoma-metastasis
#9
Elif B Turkoglu, Sara E Lally, Carol L Shields
PURPOSE: To report a case of choroidal sarcoid granuloma simulating choroidal metastasis in a patient with prostate carcinoma. METHOD: Case report. RESULTS: A 66-year-old man was found to have an asymptomatic choroidal mass in his left eye. He had known history of pulmonary sarcoidosis without systemic involvement and prostate carcinoma without metastasis. On examination, visual acuity was 20/20 in each eye. Anterior segment was normal, without inflammatory sign in either eye...
October 18, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27698552/profile-of-adalimumab-and-its-potential-in-the-treatment-of-uveitis
#10
Stephen J Balevic, C Egla Rabinovich
Uveitis refers to the presence of intraocular inflammation, and as a strict definition compromises the iris and ciliary body anteriorly and the choroid posteriorly (the uvea). Untreated, uveitis can lead to visual loss or blindness. The etiology of uveitis can include both infectious and noninfectious (usually immune-mediated) causes, the latter of which are often mediated predominantly by Th1 CD4(+) T-cells that secrete proinflammatory cytokines. Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine involved in the pathogenesis of uveitis, which at high concentrations can cause excess inflammation and tissue damage...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27646473/latent-tuberculosis-related-scleritis-a-case-report
#11
Houssaine Ait Lhaj, Amine Benjelloun, Youssef Bouia, Youssef Bennouk, Yassine Mouzari, Youssef El Kamouni, Mohamed Kriet
BACKGROUND: Scleritis is a painful inflammatory process centered in the sclera that may involve the cornea and the underlying uvea. The etiology is commonly idiopathic or autoimmune but some cases are associated with systemic infection such as tuberculosis. CASE PRESENTATION: In this report, we describe an unusual case of a female Moroccan patient who had a long history of bilateral recurrent scleritis associated with peripheral keratopathy and anterior uveitis...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27631190/a-comprehensive-proteomics-analysis-of-the-human-iris-tissue-ready-to-embrace-postgenomics-precision-medicine-in-ophthalmology
#12
Krishna R Murthy, Manjunath Dammalli, Sneha M Pinto, Kalpana Babu Murthy, Raja Sekhar Nirujogi, Anil K Madugundu, Gourav Dey, Yashwanth Subbannayya, Uttam Kumar Mishra, Bipin Nair, Harsha Gowda, T S Keshava Prasad
The annual economic burden of visual disorders in the United States was estimated at $139 billion. Ophthalmology is therefore one of the salient application fields of postgenomics biotechnologies such as proteomics in the pursuit of global precision medicine. Interestingly, the protein composition of the human iris tissue still remains largely unexplored. In this context, the uveal tract constitutes the vascular middle coat of the eye and is formed by the choroid, ciliary body, and iris. The iris forms the anterior most part of the uvea...
September 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27587955/eye-globe-abnormalities-on-mr-and-ct-in-adults-an-anatomical-approach
#13
REVIEW
James Thomas Patrick Decourcy Hallinan, Premilla Pillay, Lilian Hui Li Koh, Kong Yong Goh, Wai-Yung Yu
Eye globe abnormalities can be readily detected on dedicated and non-dedicated CT and MR studies. A primary understanding of the globe anatomy is key to characterising both traumatic and non-traumatic globe abnormalities. The globe consists of three primary layers: the sclera (outer), uvea (middle), and retina (inner layer). The various pathological processes involving these layers are highlighted using case examples with fundoscopic correlation where appropriate. In the emergent setting, trauma can result in hemorrhage, retinal/choroidal detachment and globe rupture...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27585567/cystoid-macular-edema-associated-with-iridocorneal-endothelial-syndrome-a-case-report
#14
Keita Suzuki, Tadashi Mizuguchi, Yui Seno, Atsuhiro Tanikawa, Masayuki Horiguchi
BACKGROUND: Iridocorneal endothelial (ICE) syndrome occurs mainly in young and middle-aged women and typically presents as a unilateral disease characterized by abnormalities of the iris and corneal endothelium. While the ICE syndrome is known to be associated with glaucoma and bullous keratopathy, to our knowledge, only two cases of ICE syndrome complicated with cystoid macular edema (CME) have been reported to date. In this paper, we report a case of ICE syndrome complicated with CME treated at our institution...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27562111/choroidal-nevi
#15
David S Williams
Choroidal nevi are common benign melanocytic lesions of the posterior uvea.
2016: Journal of Insurance Medicine
https://www.readbyqxmd.com/read/27560850/exophthalmos-diplopia-and-bilateral-eyelid-edema-symptoms-of-ocular-mastocytosis
#16
Arnaud Payerols, Eric Frouin, Aurélie Schiffmann, Nicolas Menjot de Champfleur, Danielle Canioni, Olivia Chandesris, Valérie Costes, Max Villain, Frédéric Mura
PURPOSE: Mastocytosis is characterized by clonal mast cell proliferation with accumulation within various organs and uncontrolled activation with excessive mast cell mediator release. Ocular manifestations have rarely been published. We describe a 63-year-old man with bilateral exophthalmos that led to the diagnosis of systemic mastocytosis. CASE REPORT: A patient presented with bilateral eyelid edema with exophthalmos associated with binocular diplopia. Ophthalmologic examination showed bilateral axial, symmetrical, and painless exophthalmos with eyelid edema, and limitation in elevation of the right eye...
August 24, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27387571/reply-re-renal-carcinoid-tumor-metastatic-to-the-uvea-medial-rectus-muscle-and-the-contralateral-lacrimal-gland
#17
Hayyam Kiratli, Salih Uzun, Berçin Tarlan, Deniz Ateş, Dilek Ertok Baydar, Figen Söylemezoğlu
No abstract text is available yet for this article.
July 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27387570/re-renal-carcinoid-tumor-metastatic-to-the-uvea-medial-rectus-muscle-and-the-contralateral-lacrimal-gland
#18
Nora Silverman, Roman Shinder
No abstract text is available yet for this article.
July 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27374654/epidemiological-aspects-of-malignant-melanoma-of-the-uvea-in-tunisia
#19
Amel Chebbi, Hedi Bouguila, Nedia Alaya, Houda Lejmi, Ines Malek, Imen Zeghal, Leila Nacef
BACKGROUND: to assess clinical factors that may influence the prognosis of malignant melanoma of the uvea Methods: We conducted a retrospective study from January 1990 to December 2013, involving 80 patients suffering from malignant melanoma of the uvea. We determined the location, the size, the tumor thickness, the clinicopathological aspect, the degree of pigmentation of the uveal melanoma, and associated signs Results: Factors significantly associated with poor prognosis were: a tumor location (p = 0...
August 2015: La Tunisie Médicale
https://www.readbyqxmd.com/read/27344152/immunological-and-pathological-investigations-in-equine-experimental-uveitis
#20
Galina P Simeonova, Svetozar Z Krastev, Radostin S Simeonov
BACKGROUND: The pathogenic mechanism of equine recurrent uveitis (ERU) is still poorly defined and many variations between experimental animal models and spontaneous disease exist. OBJECTIVES: The aim of our study was to investigate if Th17 cell-mediated response plays role in the pathogenesis of the used experimental model in horses and to reveal its pathological findings. METHODS: Experimental uveitis was induced in 6 healthy horses. The concentrations of retinal autoantigen CRALBP and IL-17 were measured using ELISA in aqueous humor and vitreous body of the 12 inflamed eyes as well as in 12 control non-inflamed eyes taken from 6 horses in slaughter house...
June 25, 2016: Veterinary Research Communications
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