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https://www.readbyqxmd.com/read/29145268/seroconverting-nonresponder-of-high-dose-intramuscular-hbv-vaccine-with-intradermal-hbv-vaccine-a-case-report
#1
Manjusha Das, Vishwas Vanar, Daniel K Martin, Saqib Walayat, Jaymon Patel, Maaz B Badshah, Nikhil R Kalva, Watcoun-Nchinda Pisoh, Sonu Dhillon
INTRODUCTION: Liver disease is a leading cause of death among human immunodeficiency virus (HIV)-infected patients in the United States. Patients with HIV and hepatitis B virus (HBV) coinfection have accelerated liver disease, higher rates of cirrhosis, and liver cancer, and markedly increased liver-related mortality. The CDC and US Advisory Committee on Immunization Practices recommend hepatitis B vaccination for all HIV-infected individuals. Unfortunately, HIV-infected patients have a worse response rate after standard HBV vaccination...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144720/cost-effectiveness-of-gammacore-non-invasive-vagus-nerve-stimulation-for-acute-treatment-of-episodic-cluster-headache
#2
Mkaya Mwamburi, Eric J Liebler, Andrew T Tenaglia
Cluster headache is a debilitating disease characterized by excruciatingly painful attacks that affects 0.15% to 0.4% of the US population. Episodic cluster headache manifests as circadian and circannual seasonal bouts of attacks, each lasting 15 to 180 minutes, with periods of remission. In chronic cluster headache, the attacks occur throughout the year with no periods of remission. While existing treatments are effective for some patients, many patients continue to suffer. There are only 2 FDA-approved medications for episodic cluster headache in the United States, while others, such as high-flow oxygen, are used off-label...
November 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29141246/evaluation-of-temporal-virological-responses-to-interferon-%C3%AE-2b-plus-ribavirin-among-genotype-3a-hepatitis-c-virus-infected-patients
#3
Abida Raza, Muhammad Ovais, Hafsa Aziz, Asim Anwar, Javaid Irfan, Irshad Ahmad, Muhammad Mukhtar
OBJECTIVES: The present study aimed to examine the impact of rapid virological response (RVR) and early virological response (EVR) on sustained virological response (SVR) in chronic hepatitis C genotype 3a individuals. METHODS: The patients were given antiviral therapy with IFN-α-2b, 3 million units 3 times a week and 800-1,200 mg of ribavirin daily adjusted to the patient's body weight (<60 kg 800 mg day-1, and >60 kg 1,200 day-1). The patients received this combination therapy for 24 weeks...
November 16, 2017: Intervirology
https://www.readbyqxmd.com/read/29138699/for-better-or-worse-the-effect-of-prismatic-adaptation-on-auditory-neglect
#4
Isabel Tissieres, Mona Elamly, Stephanie Clarke, Sonia Crottaz-Herbette
Patients with auditory neglect attend less to auditory stimuli on their left and/or make systematic directional errors when indicating sound positions. Rightward prismatic adaptation (R-PA) was repeatedly shown to alleviate symptoms of visuospatial neglect and once to restore partially spatial bias in dichotic listening. It is currently unknown whether R-PA affects only this ear-related symptom or also other aspects of auditory neglect. We have investigated the effect of R-PA on left ear extinction in dichotic listening, space-related inattention assessed by diotic listening, and directional errors in auditory localization in patients with auditory neglect...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29138610/nab-paclitaxel-carboplatin-induction-in-squamous-nsclc-longitudinal-quality-of-life-while-on-chemotherapy
#5
Michael Thomas, David R Spigel, Robert M Jotte, Michael McCleod, Mark A Socinski, Ray D Page, Laurent Gressot, Jeanna Knoble, Oscar Juan, Daniel Morgensztern, Dolores Isla, Edward S Kim, Howard West, Amy Ko, Teng Jin Ong, Nataliya Trunova, Cesare Gridelli
Background: Longitudinal data on the impact of treatment on quality of life (QoL) in advanced non-small cell lung cancer (NSCLC) are limited. In this palliative setting, treatment that does not deteriorate QoL is key. Here we report longitudinal QoL in patients with squamous NSCLC, receiving ≤4 cycles of nab-paclitaxel/carboplatin combination chemotherapy. Methods: Patients received nab-paclitaxel 100 mg/m(2) days 1, 8, 15 + carboplatin area under the curve 6 mg•min/mL day 1 (q3w) for four cycles...
2017: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29131327/cgrp-and-ptx3-as-predictors-of-efficacy-of-onabotulinumtoxin-type-a-in-chronic-migraine-an-observational-study
#6
Clara Domínguez, Alba Vieites-Prado, María Pérez-Mato, Tomás Sobrino, Xiana Rodríguez-Osorio, Ana López, Francisco Campos, Francisco Martínez, José Castillo, Rogelio Leira
OBJECTIVE: The aim of this study is to find a relation between several biomarkers in peripheral blood and outcome after treatment with onabotulinumtoxin A (OnabotA). BACKGROUND: OnabotA is an effective treatment in chronic migraine (CM). Different studies have tried to find predictors of response to treatment, either with clinical characteristics, neuroimaging features, or molecular biomarkers; however, it is still not possible to predict the individual outcome...
November 13, 2017: Headache
https://www.readbyqxmd.com/read/29128420/neoadjuvant-treatment-for-muscle-invasive-bladder-cancer-the-past-the-present-and-the-future
#7
REVIEW
Tom J N Hermans, Charlotte S Voskuilen, Michiel S van der Heijden, Bernd J Schmitz-Dräger, Wassim Kassouf, Roland Seiler, Ashish M Kamat, Petros Grivas, Anne E Kiltie, Peter C Black, Bas W G van Rhijn
BACKGROUND: Approximately half of patients who undergo radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) will succumb to metastatic disease. We summarize the evidence for neoadjuvant radiation (NAR), chemo (NAC), and immunotherapy (checkpoint inhibition) prior to RC for MIBC. MATERIALS AND METHODS: Data were obtained by a search of PubMed, ClinicalTrials.gov, and Cochrane databases for English language articles published from 1925 up to 2017. RESULTS: NAC usage has increased over the last decade, while NAR is rarely administered...
November 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29124774/early-drug-and-anti-infliximab-antibody-levels-for-prediction-of-primary-nonresponse-to-infliximab-therapy
#8
H Bar-Yoseph, N Levhar, L Selinger, U Manor, M Yavzori, O Picard, E Fudim, U Kopylov, R Eliakim, S Ben-Horin, Y Chowers, B Ungar
BACKGROUND: Primary nonresponse, defined as lack of clinical benefit during the induction phase, occurs in up to 30% of IBD patients treated with infliximab. The mechanisms underlying primary nonresponse have not yet been clearly defined. AIM: To evaluate the association of early (week 2 and week 6) induction infliximab and anti-infliximab antibody levels with primary nonresponse. METHODS: A retrospective observational case-control study of inflammatory bowel disease patients treated with infliximab and followed at Sheba Medical Center between 2009 and 2016 was performed...
November 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29115855/an-indirect-comparison-of-ustekinumab-and-vedolizumab-in-the-therapy-of-tnf-failure-crohn-s-disease-patients
#9
Paweł Kawalec, Paweł Moćko
AIM: An indirect comparison of ustekinumab versus vedolizumab in patients with active moderate-to-severe Crohn's disease who were nonresponsive or intolerant to previous TNF-antagonist therapy. METHODS: A systematic review was performed in Medline via PubMed, Embase, Cochrane Library, until 30 April 2017. Inclusion criteria were: randomized controlled trials, patients treated for Crohn's disease, ustekinumab or vedolizumab therapy. Included trials were critically appraised and afterward indirect comparison by Bucher was conducted; the manuscript was prepared in accordance to the PRISMA requirements...
November 8, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29112660/opioid-prescribing-patterns-patient-use-and-postoperative-pain-after-hysterectomy-for-benign-indications
#10
Sawsan As-Sanie, Sara R Till, Erika L Mowers, Courtney S Lim, Bethany D Skinner, Laura Fritsch, Alex Tsodikov, Vanessa K Dalton, Daniel J Clauw, Chad M Brummett
OBJECTIVE: To quantify physician prescribing patterns and patient opioid use in the 2 weeks after hysterectomy at an academic institution and to determine whether patient factors predict postsurgical opioid use and pain recovery. METHODS: We conducted a prospective quality initiative study by recruiting all English-speaking patients undergoing hysterectomy for benign, nonobstetric indications at a university hospital between August 2015 and December 2015, excluding those with major medical morbidities or substance abuse...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29107623/early-symptom-improvement-at-10-sessions-as-a-predictor-of-rtms-treatment-outcome-in-major-depression
#11
Kfir Feffer, Hyewon Helen Lee, Farrokh Mansouri, Peter Giacobbe, Fidel Vila-Rodriguez, Sidney H Kennedy, Zafiris J Daskalakis, Daniel M Blumberger, Jonathan Downar
BACKGROUND: Predicting rTMS nonresponse could be helpful in sparing patients from futile treatment, and in improving use of limited rTMS resources. While several predictive biomarkers have been proposed, few are accurate for individual-level prediction; none have entered routine use. An alternative approach in pharmacotherapy predicts outcome from early response; patients showing minimal (e.g., ≤20%) improvement at 2 weeks can be predicted as nonresponders with negative predictive values (NPV) > 80-90%...
October 19, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29102693/children-with-chronic-pain-response-trajectories-following-intensive-pain-rehabilitation-treatment
#12
Laura E Simons, Christine B Sieberg, Caitlin Conroy, Edin T Randall, Julie Shulman, David Borsook, Charles Berde, Navil F Sethna, Deirdre E Logan
Intensive pain rehabilitation programs for children with chronic pain are effective for many patients. However, characteristics associated with treatment response have not been well documented. Here we report trajectories of pain and functional impairment in patients with chronic pain up to one year after intensive pain rehabilitation and examine baseline factors associated with treatment response. Patients (n=253) with chronic pain and functional disability were assessed at 5 time points (admission, discharge, 1-month, 4-month, and 12-month follow-up)...
November 1, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29099443/association-of-response-to-inhaled-nitric-oxide-and-duration-of-mechanical-ventilation-in-pediatric-acute-respiratory-distress-syndrome
#13
Jasmine C Dowell, Neal J Thomas, Nadir Yehya
OBJECTIVES: Literature regarding appropriate use of inhaled nitric oxide for pediatric acute respiratory distress syndrome is sparse. This study aims to determine if positive response to inhaled nitric oxide is associated with decreased mortality and duration of mechanical ventilation in pediatric acute respiratory distress syndrome. DESIGN: Retrospective cohort study. SETTING: Large pediatric academic medical center. PATIENTS OR SUBJECTS: One hundred sixty-one children with pediatric acute respiratory distress syndrome and inhaled nitric oxide exposure for greater than or equal to 1 hour within 3 days of pediatric acute respiratory distress syndrome onset...
November 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29098172/texas-adolescent-tobacco-and-marketing-surveillance-system-s-design
#14
Adriana Pérez, Melissa B Harrell, Raja I Malkani, Christian D Jackson, Joanne Delk, Prince A Allotey, Krystin J Matthews, Pablo Martinez, Cheryl L Perry
Objectives: To provide a full methodological description of the design of the wave I and II (6-month follow-up) surveys of the Texas Adolescent Tobacco and Marketing Surveillance System (TATAMS), a longitudinal surveillance study of 6(th), 8(th), and 10(th) grade students who attended schools in Bexar, Dallas, Tarrant, Harris, or Travis counties, where the 4 largest cities in Texas (San Antonio, Dallas, Fort Worth, Houston, and Austin, respectively) are located. Methods: TATAMS used a complex probability design, yielding representative estimates of these students in these counties during the 2014-2015 academic year...
April 2017: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/29097058/the-quality-of-discharge-care-planning-in-acute-stroke-care-influencing-factors-and-association-with-postdischarge-outcomes
#15
Nadine E Andrew, Doreen Busingye, Natasha A Lannin, Monique F Kilkenny, Dominique A Cadilhac
BACKGROUND: Comprehensive discharge planning is important for successful transitions from hospital to home after stroke. The aim of this study was to describe the quality of discharge planning received by patients discharged home from acute care, identify factors associated with a positive discharge experience, and assess the influence of discharge quality on outcomes. METHOD: Patients discharged to the community and registered in the Australian Stroke Clinical Registry in 2014 were invited to participate...
October 30, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29095245/prospective-multicenter-randomized-crossover-clinical-trial-comparing-the-safety-and-effectiveness-of-cooled-radiofrequency-ablation-with-corticosteroid-injection-in-the-management-of-knee-pain-from-osteoarthritis
#16
Tim Davis, Eric Loudermilk, Michael DePalma, Corey Hunter, David Lindley, Nilesh Patel, Daniel Choi, Marc Soloman, Anita Gupta, Mehul Desai, Asokumar Buvanendran, Leonardo Kapural
BACKGROUND AND OBJECTIVES: Osteoarthritis (OA) of the knee affects the aging population and has an associated influence on the health care system. Rigorous studies evaluating radiofrequency ablation for OA-related knee pain are lacking. This study compared long-term clinical safety and effectiveness of cooled radiofrequency ablation (CRFA) with intra-articular steroid (IAS) injection in managing OA-related knee pain. METHODS: This is a prospective, multicenter, randomized trial with 151 subjects with chronic (≥6 months) knee pain that was unresponsive to conservative modalities...
November 1, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29092739/erythropoietic-response-to-oral-iron-in-patients-with-nondialysis-dependent-chronic-kidney-disease-in-the-find-ckd-trial%C3%A2
#17
Iain C Macdougall, Andreas H Bock, Fernando Carrera, Kai-Uwe Eckardt, Carlo Gaillard, David Van Wyck, Yvonne Meier, Sylvain Larroque, Amandine Perrin, Simon D Roger
AIMS: To evaluate erythropoietic response rates to oral iron over time in iron-deficient anemic patients with nondialysis-dependent chronic kidney disease (ND-CKD). MATERIALS AND METHODS: FIND-CKD was a 1-year, randomized, multicenter trial of iron therapy in patients with ND-CKD, anemia, and iron deficiency, without erythropoiesis-stimulating agent (ESA) therapy. Patients with active infection or C-reactive protein > 20 mg/L were excluded. In this post-hoc analysis, response was defined as ≥ 1 g/dL increase in hemoglobin (Hb) from baseline, before initiation of alternative anemia therapy (i...
October 26, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29083050/alternating-r-chop-and-r-cytarabine-is-a-safe-and-effective-regimen-for-transplant-ineligible-patients-with-a-newly-diagnosed-mantle-cell-lymphoma
#18
Pavel Klener, Eva Fronkova, David Belada, Kristina Forsterova, Robert Pytlik, Marketa Kalinova, Martin Simkovic, David Salek, Heidi Mocikova, Vit Prochazka, Petra Blahovcova, Andrea Janikova, Jana Markova, Ales Obr, Adela Berkova, Jozef Kubinyi, Martina Vaskova, Ester Mejstrikova, Vit Campr, Radek Jaksa, Roman Kodet, Kyra Michalova, Jan Trka, Marek Trneny
Implementation of cytarabine into induction therapy became standard of care for younger patients with mantle cell lymphoma (MCL). On the basis of its beneficial impact, many centers incorporated cytarabine at lower doses also into first-line treatments of elderly patients. We conducted a multicenter observational study that prospectively analyzed safety and efficacy of alternating 3 + 3 cycles of R-CHOP and R-cytarabine for newly diagnosed transplant-ineligible MCL patients. A total of 73 patients were enrolled with median age 70 years...
October 30, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/29082359/initiative-for-molecular-profiling-and-advanced-cancer-therapy-impact-an-md-anderson-precision-medicine-study
#19
Apostolia-Maria Tsimberidou, David S Hong, Yang Ye, Carrie Cartwright, Jennifer J Wheler, Gerald S Falchook, Aung Naing, Siqing Fu, Sarina Piha-Paul, Filip Janku, Funda Meric-Bernstam, Patrick Hwu, Bryan Kee, Merrill S Kies, Russell Broaddus, John Mendelsohn, Kenneth R Hess, Razelle Kurzrock
PURPOSE: Genomic profiling is increasingly used in the management of cancer. We have previously reported preliminary results of our precision medicine program. Here, we present response and survival outcomes for 637 additional patients who were referred for phase I trials and were treated with matched targeted therapy (MTT) when available. PATIENTS AND METHODS: Patients with advanced cancer who underwent tumor genomic analyses were treated with MTT when available...
2017: JCO Precis Oncol
https://www.readbyqxmd.com/read/29075649/enavatuzumab-a-humanized-anti-tweak-receptor-monoclonal-antibody-exerts-antitumor-activity-through-attracting-and-activating-innate-immune-effector-cells
#20
Shiming Ye, Melvin I Fox, Nicole A Belmar, Mien Sho, Debra T Chao, Donghee Choi, Yuni Fang, Vivian Zhao, Stephen F Keller, Gary C Starling, Patricia A Culp
Enavatuzumab is a humanized IgG1 anti-TWEAK receptor monoclonal antibody that was evaluated in a phase I clinical study for the treatment of solid malignancies. The current study was to determine whether and how myeloid effector cells were involved in postulated mechanisms for its potent antitumor activity in xenograft models. The initial evidence for a role of effector cells was obtained in a subset of tumor xenograft mouse models whose response to enavatuzumab relied on the binding of Fc of the antibody to Fcγ receptor...
2017: Journal of Immunology Research
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