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https://www.readbyqxmd.com/read/28911922/neoadjuvant-sorafenib-gemcitabine-and-cisplatin-administration-preceding-cystectomy-in-patients-with-muscle-invasive-urothelial-bladder-carcinoma-an-open-label-single-arm-single-center-phase-2-study
#1
Andrea Necchi, Salvatore Lo Vullo, Daniele Raggi, Federica Perrone, Patrizia Giannatempo, Giuseppina Calareso, Elena Togliardi, Nicola Nicolai, Luigi Piva, Davide Biasoni, Mario Catanzaro, Tullio Torelli, Silvia Stagni, Maurizio Colecchia, Adele Busico, Marzia Pennati, Nadia Zaffaroni, Luigi Mariani, Roberto Salvioni
BACKGROUND: Outcomes of neoadjuvant chemotherapy in patients with muscle-invasive urothelial bladder carcinoma (MIUBC) should be improved. Sorafenib was combined with gemcitabine and cisplatin chemotherapy (SGC) in an open-label, single-arm, phase 2 trial (NCT01222676). PATIENTS AND METHODS: After transurethral resection of the bladder, T2-T4a N0 patients received four cycles of SGC followed by cystectomy. Sorafenib 400mg q12h daily, continuously, was added to standard GC chemotherapy...
September 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28911006/ghrelin-serum-concentrations-are-associated-with-treatment-response-during-lithium-augmentation-of-antidepressants
#2
Roland Ricken, Sandra Bopp, Peter Schlattmann, Hubertus Himmerich, Tom Bschor, Christoph Richter, Samuel Elstner, Thomas J Stamm, Brigitte Schulz-Ratei, Alexandra Lingesleben, Friedel M Reischies, Philipp Sterzer, Stefan Borgwardt, Michael Bauer, Andreas Heinz, Rainer Hellweg, Undine E Lang, Mazda Adli
Background: Lithium augmentation of antidepressants is an effective strategy in treatment-resistant depression. The proteohormone ghrelin is thought to be involved in the pathophysiology of depression. The purpose of this study was to investigate the association of treatment response with the course of ghrelin levels during lithium augmentation. Method: Ghrelin serum concentrations and severity of depression were measured in 85 acute depressive patients before and after 4 weeks of lithium augmentation...
September 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28910442/unilateral-laryngoscopic-findings-associated-with-response-to-gabapentin-in-patients-with-chronic-cough
#3
John Paul Giliberto, Daniel Dibildox, Albert Merati
Importance: Chronic cough is a debilitating, often multifactorial problem. Vagal neuropathy has been proposed as a cause for a fraction of these cases. There are certain features that support the clinical diagnosis of vagal neuropathy. It is hypothesized that patients with neurogenic cough who have vocal fold motion asymmetry (VFMA) on laryngoscopy will be more likely to respond to gabapentin. Objective: To evaluate the association between the history, physical and videostroboscopic examinations, and clinical response to gabapentin...
September 14, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28906405/repetitive-optimizing-left-ventricular-pacing-configurations-with-quadripolar-leads-improves-response-to-cardiac-resynchronization-therapy-a-single-center-randomized-clinical-trial
#4
Min Gu, Han Jin, Wei Hua, Xiao-Han Fan, Li-Gang Ding, Jing Wang, Hong-Xia Niu, Chi Cai, Shu Zhang
BACKGROUND: This study aimed to investigate whether repetitive optimizing left ventricular pacing configurations (LVPCs) with quadripolar leads (QUAD) can improve response to cardiac resynchronization therapy (CRT). METHODS: Fifty-two eligible patients were enrolled and 1:1 randomized to either the quadripolar LV leads (QUAD) group or the conventional bipolar leads (CONV) group. In the QUAD group, optimization of LVPC was performed for all patients before discharge and for nonresponders at 3 months follow-up...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28902728/crohn-disease-fdg-pet-ct-before-and-after-initial-dose-of-anti-tumor-necrosis-factor-therapy-to-predict-long-term-response
#5
Yan Epelboym, Paul B Shyn, Jeffrey Forris Beecham Chick, Matthew J Hamilton, Stacy D OʼConnor, Stuart G Silverman, Chun K Kim
PURPOSE: Clinical assessments of Crohn disease activity are limited in their capacity to assess treatment response to biologic therapy. The purpose of this study was to determine if changes in FDG activity between baseline PET and repeat PET performed prior to the second dose of induction anti-tumor necrosis factor (TNF) therapy correlate with clinical response. METHODS: In this prospective, institutional review board-approved, Health Insurance Portability and Accountability Act-compliant pilot study of 8 adult patients with active Crohn disease, FDG activity before and 2 weeks after initiation of anti-TNF therapy was assessed using low-dose PET/CT...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28901594/quantitative-evaluation-of-breast-cancer-response-to-neoadjuvant-chemotherapy-by-diffusion-tensor-imaging-initial-results
#6
Edna Furman-Haran, Noam Nissan, Verónica Ricart-Selma, Carmen Martinez-Rubio, Hadassa Degani, Julia Camps-Herrero
BACKGROUND: Diffusion tensor imaging (DTI) yields several parameters that have not been tested in response evaluation to neoadjuvant chemotherapy (NAC). PURPOSE: To evaluate and compare in reference to histopathology findings the ability of DTI and dynamic contrast-enhanced (DCE) MRI to monitor response to NAC. STUDY TYPE: Retrospective. POPULATION: Twenty patients treated with neoadjuvant chemotherapy. FIELD STRENGTH/SEQUENCE: 1...
September 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28898872/macrophage-derived-chemokine-a-putative-marker-of-pharmacological-therapy-response-in-major-depression
#7
Vladimir M Milenkovic, Nina Sarubin, Sven Hilbert, Thomas C Baghai, Friederike Stöffler, Juan M Lima-Ojeda, André Manook, Khalifa Almeqbaali, Christian H Wetzel, Rainer Rupprecht, Caroline Nothdurfter
INTRODUCTION: Inflammatory processes play an important and complex role in the pathophysiology of major depressive disorder (MDD), but, so far, no specific investigation of chemokines exists. METHODS: In this study, we investigated the changes of plasma chemokine levels (eotaxin-1, eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, and TARC) in 47 MDD patients before (PRE) and after 1 and 6 weeks of pharmacological treatment (POST1 and POST6) in relation to the response to antidepressive therapy...
September 13, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28894313/need-for-a-randomized-controlled-trial-of-stress-ulcer-prophylaxis-in-critically-ill-children-a-canadian-survey
#8
Mark Duffett, Karen Choong, Jennifer Foster, Elaine Gilfoyle, Jacques Lacroix, Deborah J Cook
BACKGROUND: Stress ulcer prophylaxis is commonly used in pediatric critical care, to prevent upper gastrointestinal bleeding. The most frequently used agents are histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs). The risk-benefit ratio for stress ulcer prophylaxis is uncertain, because data from randomized clinical trials (RCTs) on the effectiveness and harms of prophylaxis in children are limited. OBJECTIVE: To describe the views of Canadian pediatric intensivists about a future RCT of stress ulcer prophylaxis...
July 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28892430/characterization-of-pulmonary-metastases-in-children-with-hepatoblastoma-treated-on-children-s-oncology-group-protocol-ahep0731-the-treatment-of-children-with-all-stages-of-hepatoblastoma-a-report-from-the-children-s-oncology-group
#9
Allison F O'Neill, Alexander J Towbin, Mark D Krailo, Caihong Xia, Yun Gao, M Beth McCarville, Rebecka L Meyers, Eugene D McGahren, Greg M Tiao, Stephen P Dunn, Max R Langham, Christopher B Weldon, Milton J Finegold, Sarangarajan Ranganathan, Wayne L Furman, Marcio Malogolowkin, Carlos Rodriguez-Galindo, Howard M Katzenstein
Purpose To determine whether the pattern of lung nodules in children with metastatic hepatoblastoma (HB) correlates with outcome. Methods Thirty-two patients with metastatic HB were enrolled on Children's Oncology Group Protocol AHEP0731 and treated with vincristine and irinotecan (VI). Responders to VI received two additional cycles of VI intermixed with six cycles of cisplatin/fluorouracil/vincristine/doxorubicin (C5VD), and nonresponders received six cycles of C5VD alone. Patients were imaged after every two cycles and at the conclusion of therapy...
September 11, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28888827/tumor-dose-response-in-yttrium-90-resin-microsphere-embolization-for-neuroendocrine-liver-metastases-a-tumor-specific-analysis-with-dose-estimation-using-spect-ct
#10
Orapin Chansanti, Younes Jahangiri, Yusuke Matsui, Akira Adachi, Yindee Geeratikun, John A Kaufman, Kenneth J Kolbeck, Jeffrey S Stevens, Khashayar Farsad
PURPOSE: To evaluate dose-response relationship in yttrium-90 ((90)Y) resin microsphere radioembolization for neuroendocrine tumor (NET) liver metastases using a tumor-specific dose estimation based on technetium-99m-labeled macroaggregated albumin ((99m)Tc MAA) single photon emission computed tomography (SPECT)-CT. MATERIALS AND METHODS: Fifty-five tumors (mean size 3.9 cm) in 15 patients (10 women; mean age 57 y) were evaluated. Tumor-specific absorbed dose was estimated using a partition model...
September 6, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28885359/sustained-dysfunctional-information-processing-in-patients-with-internet-gaming-disorder-6-month-follow-up-erp-study
#11
Minkyung Park, Yeon Jin Kim, Dai Jin Kim, Jung-Seok Choi
Internet gaming disorder (IGD), defined as an inability to control Internet-based game play, leads to serious impairment in psychological and social functioning, but few studies have identified the neurophysiological characteristics of patients with IGD. The aim of this study was to determine neurophysiological markers of P300 components associated with changes in symptoms after outpatient management with pharmacotherapy in patients with IGD. The present prospective longitudinal study included 18 patients with IGD and 29 healthy controls...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28883848/interleukin-6-signaling-in-patients-with-chronic-heart-failure-treated-with-cardiac-resynchronization-therapy
#12
Katarzyna Ptaszynska-Kopczynska, Anna Szpakowicz, Marta Marcinkiewicz-Siemion, Anna Lisowska, Ewa Waszkiewicz, Marcin Witkowski, Piotr Jakim, Bogdan Galar, Wlodzimierz J Musial, Karol A Kamiński
INTRODUCTION: Increased expression of interleukin-6 (IL-6) has been described in left ventricular dysfunction in the course of chronic heart failure. Cardiac resynchronization therapy (CRT) is a unique treatment method that may reverse the course of chronic heart failure (CHF) with reduced ejection fraction (HF-REF). We aimed to evaluate the IL-6 system, including soluble IL-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130), in HF-REF patients, with particular emphasis on CRT effects...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28881017/the-body-composition-profile-is-associated-with-response-to-anti-tnf-therapy-in-crohn-s-disease-and-may-offer-an-alternative-dosing-paradigm
#13
N S Ding, G Malietzis, P F C Lung, L Penez, W M Yip, S Gabe, J T Jenkins, A Hart
BACKGROUND: Anti-tumour necrosis factor (TNF)s form a major part of therapy in Crohn's disease and have a primary nonresponse rate of 10%-30% and a secondary loss of response rate of 5% per year. Myopenia is prevalent in Crohn's disease and is measured using body composition analysis tools. AIM: To test the hypothesis that body composition can predict outcomes of anti-TNF primary nonresponse and secondary loss of response. METHODS: Between January 2007 and June 2012, 106 anti-TNF naïve patients underwent anti-TNF therapy for Crohn's disease with body composition parameters analysed using CT scans to estimate body fat-free mass...
September 7, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28879707/analysis-of-hepatitis-c-virus-ns5a-region-in-patients-with-cirrhosis-using-an-ultra-deep-pyrosequencing-method
#14
Fahriye Keskin, Sevgi Ciftci, Filiz Akyuz, Neslihan Abaci, Aris Cakiris, Umit Akyuz, Kadir Demir, Fatih Besisik, Duran Ustek, Sabahattin Kaymakoglu
BACKGROUND: HCV (Hepatitis C Virus) is genetically more diverse than HBV and HIV (Human Immunodeficiency Virus) and exists as quasispecies within infected individuals. This is due to the lack of efficient proofreading of the viral RNA-dependent RNA polymerase. Consequently, quasispecies emerge depending on the mutation rate of the viral polymerase, which may display a high level of genetic variability in a population. In infected individuals, HCV replicates and circulates as quasispecies composed of a complex mixture of different but closely related genomes that undergoes continuous change due to competitive selection and cooperation between arising mutants...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28877643/a-case-series-of-18-patients-receiving-ticagrelor-after-carotid-stenting
#15
Elizabeth M Olafson, Jodi R DeGrote, Alexander Drofa, Evgueni Kouznetsov, Michael Manchak, Nathan D Leedahl, David D Leedahl
PURPOSE: Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor antagonist is often used to prevent thrombotic complications after endovascular stent placement. Most of the published experience surrounding DAPT after carotid stenting is with clopidogrel. Ticagrelor may be a promising alternative, especially in patients who may be considered nonresponders to clopidogrel. However, clinical outcomes utilizing DAPT with ticagrelor in a cohort with carotid stenting is lacking. In this case series, we describe our experience with systematic prescribing of ticagrelor after carotid stent placement in 18 patients...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28877045/advances-in-the-treatment-of-gastric-cancer
#16
David H Ilson
PURPOSE OF REVIEW: To review recent studies in esophagogastric cancer. RECENT FINDINGS: Positive emission tomography (PET) scan in follow-up after curative treatment of esophagogastric cancer did not lead to improved survival. In the preoperative treatment of esophagogastric cancer, the addition of the antivascular endothelial growth factor agent bevacizumab to perioperative chemotherapy with combination epirubicin, cisplatinum, and 5-fluorouracil (5-FU; ECF) failed to improve survival compared with chemotherapy alone...
September 4, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28874763/brain-grey-matter-volume-alterations-associated-with-antidepressant-response-in-major-depressive-disorder
#17
Jia Liu, Xin Xu, Qiang Luo, Ya Luo, Ying Chen, Su Lui, Min Wu, Hongyan Zhu, Graham J Kemp, Qiyong Gong
Not all patients with major depressive disorder respond to adequate pharmacological therapy. Psychoradiological studies have reported that antidepressant responders and nonresponders show different alterations in brain grey matter, but the findings are inconsistent. The present study reports a meta-analysis of voxel-based morphometric studies of patients with major depressive disorder, both antidepressant responders and nonresponders, using the anisotropic effect size version of Seed-based D Mapping to identify brain regions correlated to clinical response...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874460/citric-acid-metabolism-in-resistant-hypertension-underlying-mechanisms-and-metabolic-prediction-of-treatment-response
#18
Marta Martin-Lorenzo, Paula J Martinez, Montserrat Baldan-Martin, Gema Ruiz-Hurtado, Jose Carlos Prado, Julian Segura, Fernando de la Cuesta, Maria G Barderas, Fernando Vivanco, Luis Miguel Ruilope, Gloria Alvarez-Llamas
Resistant hypertension (RH) affects 9% to 12% of hypertensive adults. Prolonged exposure to suboptimal blood pressure control results in end-organ damage and cardiovascular risk. Spironolactone is the most effective drug for treatment, but not all patients respond and side effects are not negligible. Little is known on the mechanisms responsible for RH. We aimed to identify metabolic alterations in urine. In addition, a potential capacity of metabolites to predict response to spironolactone was investigated...
September 5, 2017: Hypertension
https://www.readbyqxmd.com/read/28870474/hmgb1-values-and-response-to-hbv-vaccine-in-children-with-celiac-disease
#19
Sara Manti, Caterina Cuppari, Giuseppe F Parisi, Lucia Tardino, Carmelo Salpietro, Salvatore Leonardi
OBJECTIVES: In addition to its wide clinical variability, celiac disease (CD) can also cause a lower response to the hepatitis B virus (HBV) than healthy individuals. The aim of this study was to examine high mobility group box 1 (HMGB1) as a new potential marker of an inadequate response to HBV vaccine in children with CD at diagnosis before starting a gluten-free diet. METHODS: We recruited 49 children with CD who were tested at admission for immunization against HBV...
October 2017: Nutrition
https://www.readbyqxmd.com/read/28867117/pet-computed-tomography-and-precision-medicine-musculoskeletal-sarcoma
#20
REVIEW
Asha Kandathil, Rathan M Subramaniam
Skeletal and soft tissue sarcomas need early and accurate diagnosis, staging, and treatment for optimal outcome. (18)F-FDG PET/computed tomography (CT) is indicated in staging of patients with high-grade sarcomas and acts as a surrogate marker of histopathologic grade, guiding biopsy to most aggressive portion of the tumor. Pretherapy and posttherapy (18)F-FDG PET/CT metabolic parameters are reliable indicators of survival in patients with sarcoma with an important role in posttreatment response assessment, enabling the treatment plan to be modified in nonresponders...
October 2017: PET Clinics
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