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JOURNAL ARTICLE
Michael Rade, Nora Grieb, Ronald Weiss, Jaren Sia, Luise Fischer, Patrick Born, Andreas Boldt, Stephan Fricke, Paul Franz, Jonathan Scolnick, Lakshmi Venkatraman, Stacy Xu, Christina Kloetzer, Simone Heyn, Anne Sophie Kubasch, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Jule Ussmann, Birthe Schetschorke, Saskia Hell, Sebastian Schwind, Klaus H Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrich Sack, Ulrike Köhl, Uwe Platzbecker, Kristin Reiche, Vladan Vucinic, Maximilian Merz
Markers that predict response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple myeloma are currently missing. We subjected mononuclear cells isolated from peripheral blood and bone marrow before and after the application of approved B cell maturation antigen-directed CAR T cells to single-cell multiomic analyses to identify markers associated with resistance and early relapse. Differences between responders and nonresponders were identified at the time of leukapheresis...
April 19, 2024: Nature Cancer
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JOURNAL ARTICLE
Justin E Vranic, Adam A Dmytriw, Inka K Berglar, Naif M Alotaibi, Nicole M Cancelliere, Christopher J Stapleton, James D Rabinov, Pablo Harker, Rajiv Gupta, Joshua D Bernstock, Matthew J Koch, Scott B Raymond, Justin R Mascitelli, T Tyler Patterson, Joshua Seinfeld, Andrew White, David Case, Christopher Roark, Chirag D Gandhi, Fawaz Al-Mufti, Jared Cooper, Charles Matouk, Nanthiya Sujijantarat, Diego A Devia, Maria I Ocampo-Navia, Daniel E Villamizar-Torres, Juan C Puentes, Mohamed M Salem, Ammad Baig, Kareem El Namaani, Anna Luisa Kühn, Bryan Pukenas, Brian T Jankowitz, Jan Karl Burkhardt, Adnan Siddiqui, Pascal Jabbour, Jasmeet Singh, Ajit S Puri, Robert W Regenhardt, Vitor Mendes Pereira, Aman B Patel
BACKGROUND AND OBJECTIVES: Dual antiplatelet therapy (DAPT) is necessary to minimize the risk of periprocedural thromboembolic complications associated with aneurysm embolization using pipeline embolization device (PED). We aimed to assess the impact of platelet function testing (PFT) on reducing periprocedural thromboembolic complications associated with PED flow diversion in patients receiving aspirin and clopidogrel. METHODS: Patients with unruptured intracranial aneurysms requiring PED flow diversion were identified from 13 centers for retrospective evaluation...
April 18, 2024: Neurosurgery
#3
JOURNAL ARTICLE
Ravi B Patel, Frank E Silvestry, Jan Komtebedde, Scott D Solomon, Gerd Hasenfuß, Sheldon E Litwin, Barry A Borlaug, Matthew J Price, Rami Kawash, Scott L Hummel, Donald E Cutlip, Martin B Leon, Dirk J van Veldhuisen, Andreas J Rieth, Scott McKenzie, Heiko Bugger, Jeremy A Mazurek, Samir R Kapadia, Marc Vanderheyden, Bonnie Ky, Sanjiv J Shah
IMPORTANCE: Although the results of A Study to Evaluate the Corvia Medical Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients with Heart Failure (REDUCE LAP-HF II) trial were neutral overall, atrial shunt therapy demonstrated potential efficacy in responders (no latent pulmonary vascular disease and no cardiac rhythm management device). Post hoc analyses were conducted to evaluate the effect of shunt vs sham stratified by responder status. OBJECTIVE: To evaluate the effect of atrial shunt vs sham control on cardiac structure/function in the overall study and stratified by responder status...
April 17, 2024: JAMA Cardiology
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JOURNAL ARTICLE
Roshan Acharya, Christopher J Peterson, Mahtab B Foroozesh
BACKGROUND: Since the start of the coronavirus disease (COVID-19) pandemic, the residency and fellowship recruitment process has changed significantly with the use of virtual interview (VI) platforms. Pulmonary and critical care medicine (PCCM) candidates reported in a survey that VIs hindered their ability to evaluate their fit within the program. However, the program directors' (PDs') opinion of this process remains unknown. OBJECTIVE: We aim to provide insight into the PCCM fellowship PDs' perspective regarding the virtual recruitment process since the first class of fellows undergoing this process has now completed 1 year of training...
March 2024: ATS scholar
#5
JOURNAL ARTICLE
Joy Melnikow, Andrew Padovani, Jingwen Zhang, Marykate Miller, Melissa Gosdin, Sabrina Loureiro, Brock Daniels
OBJECTIVE: COVID-19 vaccination is critical for reducing serious illness and hospitalizations, yet many remain hesitant. We conducted a survey of frontline physicians to identify patient concerns and physician strategies to address COVID-19 vaccine-hesitancy. METHODS: A national random sample of physicians in frontline specialties selected from a comprehensive list of practicing physicians in the U.S. were emailed a survey in August 2021. Multiple choice and open-ended questions inquired about patient concerns related to the COVID-19 vaccines and strategies used by physicians to counter vaccine misinformation and encourage vaccine-hesitant patients...
April 15, 2024: Vaccine
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JOURNAL ARTICLE
Clara Podmore, Kevin Selby, Christopher D Jensen, Wei K Zhao, Noel S Weiss, Theodore R Levin, Joanne Schottinger, Chyke A Doubeni, Douglas A Corley
IMPORTANCE: Organized screening outreach can reduce differences in colorectal cancer (CRC) incidence and mortality between demographic subgroups. Outcomes associated with additional outreach, beyond universal outreach, are not well known. OBJECTIVE: To compare CRC screening completion by race and ethnicity, age, and sex after universal automated outreach and additional personalized outreach. DESIGN, SETTING, AND PARTICIPANTS: This observational cohort study included screening-eligible individuals aged 50 to 75 years assessed during 2019 in a community-based organized CRC screening program within the Kaiser Permanente Northern California (KPNC) integrated health care delivery setting...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Giulia Matusali, Alessandra Vergori, Eleonora Cimini, Davide Mariotti, Valentina Mazzotta, Alessandro Cozzi Lepri, Francesca Colavita, Roberta Gagliardini, Stefania Notari, Silvia Meschi, Marisa Fusto, Eleonora Tartaglia, Enrico Girardi, Fabrizio Maggi, Andrea Antinori
We estimated the dynamics of the neutralizing response against XBB sublineages and T cell response in persons with HIV (PWH) with previous AIDS and/or CD4 < 200/mm3 receiving the bivalent original strain/BA.4-5 booster dose in fall 2022. Samples were collected before the shot (Day 0), 15 days, 3, and 6 months after. PWH were stratified by immunization status: hybrid immunity (HI; vaccination plus COVID-19) versus nonhybrid immunity (nHI; vaccination only). Fifteen days after the booster, 16% and 30% of PWH were nonresponders in terms of anti-XBB...
April 2024: Journal of Medical Virology
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JOURNAL ARTICLE
Débora Moroto, Isabel C O Torquato-Vieira, Lia B Fiorin, Cléber P Camacho, Mário Luiz V Castiglioni, Rui M B Maciel, Reinaldo P Furlanetto, Luiza K Matsumura, Carolina C P S Janovsky, Susan C Lindsey, João Roberto M Martins
PURPOSE: This article aims to describe the presentation of Plummer disease and its evolution after radioiodine treatment and determine factors that may influence treatment efficacy. PATIENTS AND METHODS: The sample included retrospective medical records of 165 adult patients with toxic nodular goiter treated with radioiodine between 1997 and 2017, followed up at a single thyroid center. RESULTS: The efficacy of treatment with a single dose of radioiodine was higher than 90%...
April 12, 2024: Clinical Nuclear Medicine
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JOURNAL ARTICLE
Ulla Kring Hansen, Candice D Church, Ana Micaela Carnaz Simões, Marcus Svensson Frej, Amalie Kai Bentzen, Siri A Tvingsholm, Jürgen C Becker, Steven P Fling, Nirasha Ramchurren, Suzanne L Topalian, Paul T Nghiem, Sine Reker Hadrup
Merkel cell carcinoma (MCC) is a highly immunogenic skin cancer primarily induced by Merkel cell polyomavirus, which is driven by the expression of the oncogenic T antigens (T-Ags). Blockade of the programmed cell death protein-1 (PD-1) pathway has shown remarkable response rates, but evidence for therapy-associated T-Ag-specific immune response and therapeutic strategies for the nonresponding fraction are both limited. We tracked T-Ag-reactive CD8+ T cells in peripheral blood of 26 MCC patients under anti-PD1 therapy, using DNA-barcoded pMHC multimers, displaying all peptides from the predicted HLA ligandome of the oncoproteins, covering 33 class I haplotypes...
January 30, 2024: Journal of Clinical Investigation
#10
JOURNAL ARTICLE
Felix Gerhardt, Eva Fiessler, Karen M Olsson, Moritz Z Kayser, Gabor Kovacs, Henning Gall, H Ardeschir Ghofrani, Roza Badr Eslam, Irene M Lang, Nicola Benjamin, Ekkehard Grünig, Michael Halank, Tobias J Lange, Silvia Ulrich, Hanno Leuchte, Matthias Held, Hans Klose, Ralf Ewert, Heinrike Wilkens, Carmen Pizarro, Dirk Skowasch, Max Wissmüller, Martin Hellmich, Horst Olschewski, Marius M Hoeper, Stephan Rosenkranz
BACKGROUND: Among patients with pulmonary arterial hypertension (PAH), acute vasoreactivity testing during right heart catheterization may identify acute vasoresponders, for whom treatment with high-dose calcium channel blockers (CCBs) is recommended. However, long-term outcomes in the current era remain largely unknown. We sought to evaluate the implications of acute vasoreactivity response for long-term response to CCBs and other outcomes. METHODS: Patients diagnosed with PAH between January 1999 and December 2018 at 15 pulmonary hypertension centers were included and analyzed retrospectively...
April 12, 2024: Circulation
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JOURNAL ARTICLE
Q Y Gao, B Li, S Q Qu, L J Pan, M Jiao, J Y Zhao, Z F Xu, Z J Xiao, T J Qin
Objective: To investigate the efficacy and safety of combining venetoclax (VEN) with hypomethylated drugs (HMA) in the treatment of higher-risk (IPSS-R score >3.5) myelodysplastic syndromes (MDS) . Methods: From March 2021 to December 2022, forty-five MDS patients with intermediate and high risk were treated with VEN in combination with HMAs. Clinical data were collected and analyzed retrospectively, including gender, age, MDS subtype, IPSS-R score, treatment regimen, and efficacy, etc. Kaplan-Meier method and Cox regression model were used to analyze univariate and multivariate of survival prognosis...
February 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
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JOURNAL ARTICLE
Farah Ballout, Heng Lu, Nadeem Bhat, Lei Chen, Dunfa Peng, Zheng Chen, Steven Chen, Xiaodian Sun, Silvia Giordano, Simona Corso, Alexander Zaika, Oliver McDonald, Alan S Livingstone, Wael El-Rifai
PURPOSE: TGFβ signaling is implicated in the progression of most cancers, including esophageal adenocarcinoma (EAC). Emerging evidence indicates that TGFβ signaling is a key factor in the development of resistance toward cancer therapy. EXPERIMENTAL DESIGN: In this study, we developed patient-derived organoids and patient-derived xenograft models of EAC and performed bioinformatics analysis combined with functional genetics to investigate the role of SMAD family member 3 (SMAD3) in EAC resistance to oxaliplatin...
April 9, 2024: Clinical Cancer Research
#13
JOURNAL ARTICLE
Elham Majd, Li Xing, Xuekui Zhang
BACKGROUND: The timing of treating cancer patients is an essential factor in the efficacy of treatment. So, patients who will not respond to current therapy should receive a different treatment as early as possible. Machine learning models can be built to classify responders and nonresponders. Such classification models predict the probability of a patient being a responder. Most methods use a probability threshold of 0.5 to convert the probabilities into binary group membership. However, the cutoff of 0...
April 8, 2024: BMC Medical Research Methodology
#14
JOURNAL ARTICLE
Joshua T B Williams, Kate Kurlandsky, Kristin Breslin, M Joshua Durfee, Amy Stein, Laura Hurley, Jo Ann Shoup, Liza M Reifler, Matthew F Daley, Bruno J Lewin, Kristin Goddard, Michelle L Henninger, Jennifer C Nelson, Gabriela Vazquez-Benitez, Kayla E Hanson, Candace C Fuller, Eric S Weintraub, Michael M McNeil, Simon J Hambidge
IMPORTANCE: Pregnant people and infants are at high risk of severe COVID-19 outcomes. Understanding changes in attitudes toward COVID-19 vaccines among pregnant and recently pregnant people is important for public health messaging. OBJECTIVE: To assess attitudinal trends regarding COVID-19 vaccines by (1) vaccination status and (2) race, ethnicity, and language among samples of pregnant and recently pregnant Vaccine Safety Datalink (VSD) members from 2021 to 2023...
April 1, 2024: JAMA Network Open
#15
JOURNAL ARTICLE
Akiko Yamamoto, Masashi Nagao, Yuji Nishizaki, Eri Maeda, Muneaki Ishijima
BACKGROUND AND AIMS: To investigate the factors associated with changes in bone mineral density (BMD) and the incidence of fractures in osteoporotic patients treated with denosumab. METHODS: This retrospective study included 162 osteoporotic patients treated with denosumab for 24 months between 2013 and 2019. Patients were divided according to the changes in BMD as nonresponders (NL group: <3% increase in lumbar spine BMD [LBMD], NH group: <0% increase in femoral neck BMD [FNBMD]) or responders (RL group: ≥3% increase in LBMD, RH group: ≥0% increase in FNBMD)...
April 2024: Health Science Reports
#16
JOURNAL ARTICLE
Minji Kim, Perri Vingan, Lillian A Boe, Audree B Tadros, Jonas A Nelson, Carrie S Stern
BACKGROUND: Missing data can affect the representativeness and accuracy of survey results, and sexual health-related surveys are especially at a higher risk of nonresponse due to their sensitive nature and stigma. The purpose of this study was to evaluate the proportion of patients who do not complete the BREAST-Q Sexual Well-being relative to other BREAST-Q modules and compare responders versus nonresponders of Sexual Well-being. We secondarily examined variables associated with Sexual Well-being at 1-year...
April 7, 2024: Journal of Surgical Oncology
#17
REVIEW
Hans-Christoph Diener
No abstract text is available yet for this article.
April 2024: MMW Fortschritte der Medizin
#18
JOURNAL ARTICLE
Hyun-Young Lee, Hyun-Seob Jeon, Jae-Hyuk Jang, Youngsoo Lee, Yoo Seob Shin, Dong-Ho Nahm, Hae-Sim Park, Young-Min Ye
BACKGROUND: Treating chronic urticaria (CU) that is unresponsive to H1-antihistamines (H1AHs) is challenging, and the real-world effectiveness of omalizumab remains unclear. OBJECTIVE: Our aim was to evaluate the real-world effectiveness of omalizumab, optimal response assessment timing, and predictive factors. METHODS: Initially, 5535 patients with CU who were receiving at least 20 mg of loratadine daily for at least 6 months (January 2007-August 2021) were screened...
May 2024: J Allergy Clin Immunol Glob
#19
REVIEW
Gary W Falk, Robbie Pesek
Proton pump inhibitors (PPIs), swallowed topical corticosteroids (STSs), and dupilumab are highly effective therapies for the treatment of eosinophilic esophagitis. Shared decision-making informs the choice of therapy and factors such as ease of use, safety, cost, and efficacy should be addressed. PPIs are the most common medication utilized early in the disease course; however, for nonresponders, STSs are an excellent alternative. Dupilumab is unlikely to replace PPIs or STSs as first-line therapy, except in highly specific circumstances...
May 2024: Immunology and Allergy Clinics of North America
#20
JOURNAL ARTICLE
Wen-Sheng Liu, Shih-Shin Liang, Mei-Mei Cheng, Ming-Tsan Wu, Szu-Yuan Li, Tien-Tien Cheng, Tsung-Yun Liu, Ching-Yao Tsai, Yen-Ting Lai, Chien-Hung Lin, Hsiang-Tsui Wang, Han-Hsing Tsou
The number of patients with chronic kidney disease (CKD) is increasing. Oral toxin adsorbents may provide some value. Several uremic toxins, including indoxyl sulfate (IS), p-cresol (PCS), acrolein, per- and poly-fluoroalkyl substances (PFAS), and inflammation markers (interleukin 6 [IL-6] and tumor necrosis factor [TNF]-alpha) have been shown to be related to CKD progression. A total of 81 patients taking oral activated charcoal toxin adsorbents (AC-134), which were embedded in capsules that dissolved in the terminal ileum, three times a day for 1 month, were recruited...
April 4, 2024: Environmental Toxicology
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