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https://www.readbyqxmd.com/read/28528568/a-treatment-protocol-for-management-of-bacterial-and-fungal-malignant-external-otitis-a-large-cohort-in-tehran-iran
#1
Mehrdad Hasibi, Mohammadtaghi Khorsandi Ashtiani, Masoud Motassadi Zarandi, Nasrin Yazdani, Pedram Borghei, Ali Kuhi, Sasan Dabiri, Reza Hosseini, Sara Sardashti
AIMS: High rates of negative microbiologic test results highlight the potential role of empiric antimicrobial agents in management of malignant otitis externa (MOE). This study investigates the clinical presentation, laboratory findings, and response to empiric treatment in a large group of patients admitted to a tertiary academic hospital in Tehran, Iran. METHODS AND MATERIALS: We recruited 224 patients diagnosed with MOE in a prospective observation from 2009 through 2015...
May 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28526222/hemocytometric-measures-predict-the-efficacy-of-oral-rehydration-for-children-with-postural-tachycardia-syndrome
#2
Wenxin Lu, Hui Yan, Shu Wu, Wenrui Xu, Hongfang Jin, Junbao Du
OBJECTIVE: To explore whether hemocytometric measures could be qualified predictors for the effect of oral rehydration salts (ORS) in children with postural tachycardia syndrome (POTS). STUDY DESIGN: Thirty-five children with POTS and 29 healthy children were enrolled. General information, hemodynamic status, and baseline hemocytometric variables were collected. Children with POTS received ORS therapy and were followed up for 3 months. The independent risk factors of developing POTS were explored...
May 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28524457/cyclization-of-motor-cortex-stimulation-for-neuropathic-pain-a-prospective-randomized-blinded-trial
#3
Zurab Ivanishvili, Anujan Poologaindran, Christopher R Honey
OBJECTIVES: Programming guidelines for motor cortex stimulation (MCS) in neuropathic pain requires further investigation. After optimizing voltage as a percentage of motor threshold, we evaluated the effect of cyclizing time of stimulation on pain relief for chronic neuropathic pain. METHODS: Six patients were enrolled into this trial. In a prospective, randomized, double-blinded manner, patients were programmed to receive stimulation 100, 83.3, 66.7, or 50% of the time in 30-min intervals...
May 19, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28521821/intratumoral-and-peritumoral-radiomics-for-the-pretreatment-prediction-of-pathological-complete-response-to-neoadjuvant-chemotherapy-based-on-breast-dce-mri
#4
Nathaniel M Braman, Maryam Etesami, Prateek Prasanna, Christina Dubchuk, Hannah Gilmore, Pallavi Tiwari, Donna Pletcha, Anant Madabhushi
BACKGROUND: In this study, we evaluated the ability of radiomic textural analysis of intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). METHODS: A total of 117 patients who had received NAC were retrospectively analyzed. Within the intratumoral and peritumoral regions of T1-weighted contrast-enhanced MRI scans, a total of 99 radiomic textural features were computed at multiple phases...
May 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28517367/rationale-and-design-of-a-randomized-trial-to-assess-the-safety-and-efficacy-of-multipoint-pacing-mpp-in-cardiac-resynchronization-therapy-the-mpp-trial
#5
Gery Tomassoni, James Baker, Raffaele Corbisiero, Charles Love, David Martin, Robert Sheppard, Seth J Worley, Kwangdeok Lee, Imran Niazi
BACKGROUND: Although the majority of Class III congestive heart failure (HF) patients treated with cardiac resynchronization therapy (CRT) show a clinical benefit, up to 40% of patients do not respond to CRT. This paper reports the design of the MultiPoint Pacing (MPP) trial, a prospective, randomized, double-blind, controlled study to evaluate the safety and efficacy of CRT using MPP compared to standard biventricular (Bi-V) pacing. METHODS: A maximum of 506 patients with a standard CRT-D indication will be enrolled at up to 50 US centers...
May 18, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28514289/anti-angiogenic-therapy-with-contrast-enhanced-ultrasound-in-colorectal-cancer-patients-with-liver-metastasis
#6
Zhiyong Wu, Xiaowei Yang, Li Chen, Zhikuan Wang, Yan Shi, Hui Mao, Guanghai Dai, Xiaoling Yu
The aim of the study was to evaluate the efficacy of anti-angiogenic therapy with dynamic contrast-enhanced ultrasound (DCE-US) in colorectal cancer (CRC) patients with liver metastasis.A total of 50 CRC patients with liver metastasis who received bevacizumab (BEV)-based chemotherapy (BEV + FOLFOX6 protocol) were recruited into the present study. Before the study (d0), and 3, 7, 14, and 42 days (d3, d7, d14, and d42) after chemotherapy, DCE-US was performed, and tumor perfusion was evaluated quantitatively by retention time (RT), peak enhancement (PE), and wash-in area under the curve (WiAUC) on the basis of a contrast-uptake curve determined with original linear data...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28511180/response-predictors-of-s-1-cisplatin-and-docetaxel-combination-chemotherapy-for-metastatic-gastric-cancer-microarray-analysis-of-whole-human-genes
#7
Shinji Kitamura, Toshihito Tanahashi, Eriko Aoyagi, Tadahiko Nakagawa, Koichi Okamoto, Tetsuo Kimura, Hiroshi Miyamoto, Yasuhiro Mitsui, Kazuhito Rokutan, Naoki Muguruma, Tetsuji Takayama
OBJECTIVES: The aim of this study was to identify biomarkers for predicting the efficacy of docetaxel, cisplatin, and S-1 (DCS) therapy for advanced gastric cancer using microarrays of biopsy specimens before chemotherapy. METHODS: Nineteen samples were taken from 19 patients with unresectable metastatic gastric cancer who received DCS as a first-line therapy. Laser capture microdissection was performed, and total cellular RNA was extracted from each microdissected sample...
May 17, 2017: Oncology
https://www.readbyqxmd.com/read/28506320/costs-associated-with-failure-to-respond-to-treatment-among-patients-with-rheumatoid-arthritis-initiating-tnfi-therapy-a-retrospective-claims-analysis
#8
Michael Grabner, Natalie N Boytsov, Qing Huang, Xiang Zhang, Tingjian Yan, Jeffrey R Curtis
BACKGROUND: Tumor necrosis factor inhibitors (TNFi) are common second-line treatments for rheumatoid arthritis (RA). This study was designed to compare the real-world clinical and economic outcomes between patients with RA who responded to TNFi therapy and those who did not. METHODS: For this retrospective cohort analysis we used medical and pharmacy claims from members of 14 large U.S. commercial health plans represented in the HealthCore Integrated Research Database...
May 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28504996/stroke-volume-variation-and-pulse-pressure-variation-are-not-useful-for-predicting-fluid-responsiveness-in-thoracic-surgery
#9
Dae Myoung Jeong, Hyun Joo Ahn, Hyo Won Park, Mikyung Yang, Jie Ae Kim, Joohyun Park
BACKGROUND: Stroke volume variation (SVV) and pulse pressure variation (PPV) are used as indicators of fluid responsiveness, but little is known about the usefulness of these dynamic preload indicators in thoracic surgery, which involves an open thoracic cavity and one-lung ventilation (OLV). Therefore, we investigated whether SVV and PPV could predict fluid responsiveness, and whether the thresholds of these parameters should be adjusted for thoracic surgery. METHODS: This was a prospective, controlled study conducted in a tertiary care center...
May 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28503107/the-role-of-electroconvulsive-therapy-ect-in-bipolar-disorder-effectiveness-in-522-patients-with-bipolar-depression-mixed-state-mania-and-catatonic-features
#10
Giulio Perugi, Pierpaolo Medda, Cristina Toni, Michela Giorgi Mariani, Chiara Socci, Mauro Mauri
OBJECTIVE: We evaluated the effectiveness of Electroconvulsive Therapy (ECT) in the treatment of Bipolar Disorder (BD) in a large sample of bipolar patients with drug resistant depression, mania, mixed state and catatonic features. METHOD: 522 consecutive patients with DSM-IV-TR BD were evaluated prior to and after the ECT course. Responders and nonresponders were compared in subsamples of depressed and mixed patients. Descriptive analyses were reported for patients with mania and with catatonic features...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28494048/satisfaction-and-patient-related-outcomes-in-128-patients-with-single-implant-crowns-in-situ-for-up-to-14-years
#11
Terry R Walton, Danielle M Layton
PURPOSE: To assess patient satisfaction and patient-related outcomes across the domains of appearance, cleansibility, and costs; the perceived value and worth when single implant crowns (SICs) had been in situ up to 14 years; whether satisfaction differed between patients; and whether certain characteristics might affect the questionnaire response rate. MATERIALS AND METHODS: Patients treated at a private prosthodontic practice between 2001 and 2014 (n = 207) who received a SIC (n = 256) were prospectively included...
May 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28493912/effects-of-intensity-and-amount-of-exercise-on-measures-of-insulin-and-glucose-analysis-of-inter-individual-variability
#12
Louise de Lannoy, John Clarke, Paula J Stotz, Robert Ross
AIM: To determine the separate effects of exercise amount and intensity on the rate of response for glucose and insulin variables, where rate of response was defined as the number of individuals with improvement in glucose and insulin values that was beyond the day-to-day variability of measurement. METHODS: Participants were 171 sedentary, middle-aged abdominally obese adults who completed a 24-week intervention. Participants were randomly assigned to (1) no-exercise control (n = 51), (2) low-amount, low-intensity exercise (LALI, n = 38), (3) high-amount, low-intensity exercise (HALI, n = 52), or (4) high-amount, high-intensity exercise (HAHI, n = 30)...
2017: PloS One
https://www.readbyqxmd.com/read/28490030/cognitive-behavior-therapy-may-sustain-antidepressant-effects-of-intravenous-ketamine-in-treatment-resistant-depression
#13
Samuel T Wilkinson, DaShaun Wright, Madonna K Fasula, Lisa Fenton, Matthew Griepp, Robert B Ostroff, Gerard Sanacora
INTRODUCTION: Ketamine has shown rapid though short-lived antidepressant effects. The possibility of concerning neurobiological changes following repeated exposure to the drug motivates the development of strategies that obviate or minimize the need for longer-term treatment with ketamine. In this open-label trial, we investigated whether cognitive behavioral therapy (CBT) can sustain or extend ketamine's antidepressant effects. METHODS: Patients who were pursuing ketamine infusion therapy for treatment-resistant depression were invited to participate in the study...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28488981/a-survey-of-parents-with-children-on-the-autism-spectrum-experience-with-services-and-treatments
#14
Tracy A Becerra, Maria L Massolo, Vincent M Yau, Ashli A Owen-Smith, Frances L Lynch, Phillip M Crawford, Kathryn A Pearson, Magdalena E Pomichowski, Virginia P Quinn, Cathleen K Yoshida, Lisa A Croen
INTRODUCTION: Autism spectrum disorders (ASD) are lifelong neurodevelopmental disorders, and little is known about how parents address the health and psychosocial consequences of ASD. Few studies have examined use of various treatments and services in a large, diverse sample of children with ASD and their families. OBJECTIVE: This paper presents methods to create an autism research resource across multiple large health delivery systems and describes services and treatments used by children with ASD and their families...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28482762/power-training-in-chronic-stroke-individuals-differences-between-responders-and-nonresponders
#15
Stacey E Aaron, Jennifer L Hunnicutt, Aaron E Embry, Mark G Bowden, Chris M Gregory
BACKGROUND: Lower extremity muscle weakness is a primary contributor to post-stroke dysfunction. Resistance training is an effective treatment for hemiparetic weakness and improves walking performance. Post-stroke subject characteristics that do or do not improve walking speed following resistance training are unknown. OBJECTIVE: The purpose of this paper was to describe baseline characteristics, as well as responses to training, associated with achieving a minimal clinically important difference (MCID) in walking speed (≥0...
May 8, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28472907/ifn-%C3%AE-based-treatment-of-patients-with-chronic-hcv-show-increased-levels-of-cells-with-myeloid-derived-suppressor-cell-phenotype-and-of-ido-and-nos
#16
Mohamed Labib Salem, Abdel-Aziz A Zidan, Mohamed Attia, Randa E El-Naggar, Mohamed Nassef, Abdel Raouf Abou El-Azm, Hasan El-Bate, Mohamed Yussif, Sohaila Galal, Mohamed Abo Senna, Maha El Demellawy
INTRODUCTION: Hepatitis C virus (HCV) infection causes chronic hepatitis, which is often associated with suppressed anti-HCV immune responses. We have recently reported accumulation of myeloid-derived suppressor cells (MDSCs) and suppressed immunity in cancer patients. AIM: The main aim of this study was to determine whether chronic HCV patients harbor high of MDSCs in general and in nonresponders to IFN-based therapy in particular as well as to analyze the immune suppressive molecules...
May 4, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28472801/frontal-assessment-battery-and-cerebrospinal-fluid-tap-test-in-idiopathic-normal-pressure-hydrocephalus
#17
Pan-Woo Ko, Ho-Won Lee, Kyunghun Kang
BACKGROUND AND PURPOSE: Our aim in this study was to assess whether the frontal assessment battery (FAB) could contribute to the differential diagnosis of cerebrospinal fluid tap test (CSFTT) responders and nonresponders with the hypothesis that CSFTT nonresponders had greater frontal lobe dysfunction. We also explored whether a relationship exists between FAB scores and gait disturbance in idiopathic normal-pressure hydrocephalus (INPH) patients. METHODS: INPH subjects were selected in a consecutive order from a prospectively enrolled INPH registry...
May 5, 2017: European Neurology
https://www.readbyqxmd.com/read/28467142/monitoring-neoadjuvant-chemotherapy-for-breast-cancer-by-using-three-dimensional-subharmonic-aided-pressure-estimation-and-imaging-with-us-contrast-agents-preliminary-experience
#18
Kibo Nam, John R Eisenbrey, Maria Stanczak, Anush Sridharan, Adam C Berger, Tiffany Avery, Juan P Palazzo, Flemming Forsberg
Purpose To determine whether three-dimensional subharmonic aided pressure estimation (SHAPE) and subharmonic imaging can help predict the response of breast cancer to neoadjuvant chemotherapy. Materials and Methods In this HIPAA-compliant prospective study, 17 women (age range, 45-70 years) scheduled to undergo neoadjuvant therapy for breast cancer underwent ultrasonography (US) immediately before therapy and at completion of 10%, 60%, and 100% of chemotherapy. All patients provided written informed consent...
May 3, 2017: Radiology
https://www.readbyqxmd.com/read/28463966/no-evidence-of-response-bias-in-a-population-based-childhood-cancer-survivor-questionnaire-survey-results-from-the-swiss-childhood-cancer-survivor-study
#19
Corina S Rueegg, Micòl E Gianinazzi, Gisela Michel, Marcel Zwahlen, Nicolas X von der Weid, Claudia E Kuehni
PURPOSE: This is the first study to quantify potential nonresponse bias in a childhood cancer survivor questionnaire survey. We describe early and late responders and nonresponders, and estimate nonresponse bias in a nationwide questionnaire survey of survivors. METHODS: In the Swiss Childhood Cancer Survivor Study, we compared characteristics of early responders (who answered an initial questionnaire), late responders (who answered after ≥1 reminder) and nonresponders...
2017: PloS One
https://www.readbyqxmd.com/read/28461824/clinical-usefulness-of-serum-procalcitonin-level-in-distinguishing-between-kawasaki-disease-and-other-infections-in-febrile-children
#20
Na Hyun Lee, Hee Joung Choi, Yeo Hyang Kim
PURPOSE: The aims of this study were to compare serum procalcitonin (PCT) levels between febrile children with Kawasaki disease (KD) and those with bacterial or viral infections, and assess the clinical usefulness of PCT level in predicting KD. METHODS: Serum PCT levels were examined in febrile pediatric patients admitted between August 2013 and August 2014. The patients were divided into 3 groups as follows: 49 with KD, 111 with viral infections, and 24 with bacterial infections...
April 2017: Korean Journal of Pediatrics
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