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https://www.readbyqxmd.com/read/28221763/inactivation-clearance-and-functional-effects-of-lung-instilled-short-and-long-silver-nanowires-in-rats
#1
Kian Fan Chung, Joanna Seiffert, Shu Chen, Ioannis G Theodorou, Angela Erin Goode, Bey Fen Leo, Catriona M McGilvery, Farhana Hussain, Coen Wiegman, Christos Rossios, Jie Zhu, Jicheng Gong, Farid Tariq, Vladimir Yufit, Alexander J Monteith, Teruo Hashimoto, Jeremy N Skepper, Mary P Ryan, Junfeng Jim Zhang, Teresa D Tetley, Alexandra E Porter
There is a potential for silver nanowires (AgNWs) to be inhaled but there is little information on their health effects and their chemical transformation inside the lungs in vivo. We studied the effects of short (S-AgNWs; 1.5µm) and long (L-AgNWs; 10 µm) nanowires instilled into the lungs of Sprague-Dawley rats. S- and L-AgNWs were phagocytosed and degraded by macrophages; there was no frustrated phagocytosis. Interestingly, both AgNWs were internalized in alveolar Type II epithelial cells (ATII), with precipitation of Ag2S on their surface as secondary Ag2S nanoparticles...
February 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28220893/general-planar-transverse-domain-walls-realized-by-optimized-transverse-magnetic-field-pulses-in-magnetic-biaxial-nanowires
#2
Mei Li, Jianbo Wang, Jie Lu
The statics and field-driven dynamics of transverse domain walls (TDWs) in magnetic nanowires (NWs) have attracted continuous interests because of their theoretical significance and application potential in future magnetic logic and memory devices. Recent results demonstrate that uniform transverse magnetic fields (TMFs) can greatly enhance the wall velocity, meantime leave a twisting in the TDW azimuthal distribution. For application in high-density NW devices, it is preferable to erase the twisting so as to minimize magnetization frustrations...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219490/a-multisite-study-of-family-functioning%C3%A2-impairment-in-pediatric-obsessive-compulsive-disorder
#3
S Evelyn Stewart, Yu-Pei Hu, Aldrich Leung, Elaine Chan, Dianne M Hezel, Sarah Yao Lin, Laura Belschner, Casey Walsh, Daniel A Geller, David L Pauls
OBJECTIVE: Familial aspects of pediatric obsessive-compulsive disorder (OCD), including accommodation and treatment, have received notable and warranted attention. However, individual perspectives of its repercussions on family functioning, including emotional and occupational parental burden, have not been closely examined. The present study details this topic using a large multicenter sample. METHOD: Participants included 354 youth affected with OCD and their mothers and fathers ascertained through OCD programs in Boston, Massachusetts (n = 180) and Vancouver, British Columbia (n = 174)...
March 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28218972/views-of-oral-antibiotics-and-advice-seeking-about-acne-a-qualitative-study-of-online-discussion-forums
#4
M Santer, D Chandler, M Lown, N A Francis, I Muller
BACKGROUND: Acne vulgaris is common and can significantly impair quality of life, yet little is known about patients' understanding of acne and its treatments. Oral antibiotics are widely used for acne, despite concerns about antibiotic resistance. People are increasingly turning to online discussion forums for advice and information on these sites may influence health beliefs and treatment adherence. OBJECTIVE: To explore understandings about the use of oral antibiotics for acne and advice shared amongst messages posted on online forums...
February 20, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28217726/caring-for-patients-with-advanced-breast-cancer-the-experiences-of-zambian-nurses
#5
Johanna Elizabeth Maree, Jennipher Kombe Mulonda
OBJECTIVE: The objective of this study was to describe the experiences of Zambian nurses caring for women with advanced breast cancer. METHODS: We used a qualitative descriptive design and purposive sampling. Seventeen in-depth interviews were conducted with registered nurses practicing in the Cancer Diseases Hospital and the University Teaching Hospital, Lusaka, Zambia, and analyzed using thematic analyses. RESULTS: Two themes emerged from the data - caring for women with advanced breast cancer is challenging and the good outweighs the bad...
January 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28217695/gut-microbiome-and-chronic-prostatitis-chronic-pelvic-pain-syndrome
#6
REVIEW
Hans C Arora, Charis Eng, Daniel A Shoskes
Analysis of the human microbiome continues to reveal new and previously unrealized associations between microbial dysbiosis and disease. Novel approaches to bacterial identification using culture-independent methods allow practitioners to discern the presence of alterations in the taxa and diversity of the microbiome and identify correlations with disease processes. While some of these diseases that have been extensively studied are well-defined in their etiology and treatment methods (colorectal cancer), others have provided much more significant challenges in both diagnosis and treatment...
January 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28213630/religious-coping-with-sexual-stigma-in-young-adults-with-same-sex-attractions
#7
Shauna K Lauricella, Russell E Phillips, Eric F Dubow
The present study assessed religious coping with sexual stigma in 260 young adults with same-sex attractions. Although the majority of the sample rarely utilized religious coping, a significant minority of participants frequently turned to religion to deal with sexual stigma. Controlling for demographic and general religious variables, positive religious coping (e.g., connecting with God) was associated with beneficial outcomes, and negative religious coping (e.g., frustrations with one's spiritual community) related to poorer adjustment to sexual stigma...
February 17, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28212440/emergent-inequality-and-self-organized-social-classes-in-a-network-of-power-and-frustration
#8
Benoit Mahault, Avadh Saxena, Cristiano Nisoli
We propose a simple agent-based model on a network to conceptualize the allocation of limited wealth among more abundant expectations at the interplay of power, frustration, and initiative. Concepts imported from the statistical physics of frustrated systems in and out of equilibrium allow us to compare subjective measures of frustration and satisfaction to collective measures of fairness in wealth distribution, such as the Lorenz curve and the Gini index. We find that a completely libertarian, law-of-the-jungle setting, where every agent can acquire wealth from or lose wealth to anybody else invariably leads to a complete polarization of the distribution of wealth vs...
2017: PloS One
https://www.readbyqxmd.com/read/28209972/frustration-of-crystallisation-by-a-liquid-crystal-phase
#9
Christopher D Syme, Joanna Mosses, Mario González-Jiménez, Olga Shebanova, Finlay Walton, Klaas Wynne
Frustration of crystallisation by locally favoured structures is critically important in linking the phenomena of supercooling, glass formation, and liquid-liquid transitions. Here we show that the putative liquid-liquid transition in n-butanol is in fact caused by geometric frustration associated with an isotropic to rippled lamellar liquid-crystal transition. Liquid-crystal phases are generally regarded as being "in between" the liquid and the crystalline state. In contrast, the liquid-crystal phase in supercooled n-butanol is found to inhibit transformation to the crystal...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28208395/collective-dynamics-of-time-delay-coupled-phase-oscillators-in-a-frustrated-geometry
#10
Bhumika Thakur, Devendra Sharma, Abhijit Sen, George L Johnston
We study the effect of time delay on the dynamics of a system of repulsively coupled nonlinear oscillators that are configured as a geometrically frustrated network. In the absence of time delay, frustrated systems are known to possess a high degree of multistability among a large number of coexisting collective states except for the fully synchronized state that is normally obtained for attractively coupled systems. Time delay in the coupling is found to remove this constraint and to lead to such a synchronized ground state over a range of parameter values...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208356/interaction-coalescence-and-collapse-of-localized-patterns-in-a-quasi-one-dimensional-system-of-interacting-particles
#11
Tommy Dessup, Christophe Coste, Michel Saint Jean
We study the path toward equilibrium of pairs of solitary wave envelopes (bubbles) that modulate a regular zigzag pattern in an annular channel. We evidence that bubble pairs are metastable states, which spontaneously evolve toward a stable single bubble. We exhibit the concept of topological frustration of a bubble pair. A configuration is frustrated when the particles between the two bubbles are not organized in a modulated staggered row. For a nonfrustrated (NF) bubble pair configuration, the bubbles interaction is attractive, whereas it is repulsive for a frustrated (F) configuration...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208316/bistable-director-alignments-of-nematic-liquid-crystals-confined-in-frustrated-substrates
#12
Takeaki Araki, Jumpei Nagura
We studied in-plane bistable alignments of nematic liquid crystals confined by two frustrated surfaces by means of Monte Carlo simulations of the Lebwohl-Lasher spin model. The surfaces are prepared with orientational checkerboard patterns, on which the director field is locally anchored to be planar yet orthogonal between the neighboring blocks. We found the director field in the bulk tends to be aligned along the diagonal axes of the checkerboard pattern, as reported experimentally [J.-H. Kim et al., Appl...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28198964/a-qualitative-exploration-of-facilitators-and-inhibitors-influencing-nurses-intention-to-leave-clinical-nursing
#13
Leyla Alilu, Leila Valizadeh, Vahid Zamanzadeh, Hosein Habibzadeh, Mark Gillespie
OBJECTIVE: The aim of this study was to determine the barriers and facilitators shaping the development of an intent to leave the nursing profession, from the perspective of Iran's clinical nurses. METHOD: The study was completed using qualitative content analysis And included 21 Participants who were clinical nurses with a variety of work experience across a range of clinical posts. Semi-structured interviews were used to collect data and data obtained from the interviews were analyzed and interpreted utilizing a content analysis method...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28197341/a-mixed-methods-small-pilot-study-to-describe-the-effects-of-upper-limb-training-using-a-virtual-reality-gaming-system-in-people-with-chronic-stroke
#14
Rachel C Stockley, Deborah A O'Connor, Phil Smith, Sylvia Moss, Lizzie Allsop, Wendy Edge
Introduction. This small pilot study aimed to examine the feasibility of an upper limb rehabilitation system (the YouGrabber) in a community rehabilitation centre, qualitatively explore participant experiences, and describe changes after using it. Methods and Material. Chronic stroke participants attending a community rehabilitation centre in the UK were randomised to either a YouGrabber or a gym group and completed 18 training sessions over 12 weeks. The motor activity log, box and block, and fatigue severity score were administered by a blinded assessor before and after the intervention...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28196883/evidence-for-the-principle-of-minimal-frustration-in-the-evolution-of-protein-folding-landscapes
#15
Franco O Tzul, Daniel Vasilchuk, George I Makhatadze
Theoretical and experimental studies have firmly established that protein folding can be described by a funneled energy landscape. This funneled energy landscape is the result of foldable protein sequences evolving following the principle of minimal frustration, which allows proteins to rapidly fold to their native biologically functional conformations. For a protein family with a given functional fold, the principle of minimal frustration suggests that, independent of sequence, all proteins within this family should fold with similar rates...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28196882/trade-offs-between-enzyme-fitness-and-solubility-illuminated-by-deep-mutational-scanning
#16
Justin R Klesmith, John-Paul Bacik, Emily E Wrenbeck, Ryszard Michalczyk, Timothy A Whitehead
Proteins are marginally stable, and an understanding of the sequence determinants for improved protein solubility is highly desired. For enzymes, it is well known that many mutations that increase protein solubility decrease catalytic activity. These competing effects frustrate efforts to design and engineer stable, active enzymes without laborious high-throughput activity screens. To address the trade-off between enzyme solubility and activity, we performed deep mutational scanning using two different screens/selections that purport to gauge protein solubility for two full-length enzymes...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28195409/dihydrogen-splitting-using-dialkylsilylene-based-frustrated-lewis-pairs
#17
Mitsuo Kira, Zhaowen Dong, Zhifang Li, Xupeng Liu, Chenting Yan, Ningka Wei, Thomas Müller
An Isolable dialkylsilylene reacts with dihydrogen in the presence of a small amount of a conventional Lewis acid (BPh3, BEt3) or a base (PPh3, PEt3, NPh3, NEt3) at low temperatures in a hydrocarbon solvent, giving the corresponding saturated dihydrosilane in high yields. Both 5/Lewis acid and Lewis base/5 pairs work as a frustrated Lewis pair (FLP) to split dihydrogen, being in accord with the amphoteric nature of the silylene.
February 13, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28194969/spin-frustration-in-the-triradical-trianion-of-a-naphthalenediimide-molecular-triangle
#18
Yilei Wu, Matthew D Krzyaniak, J Fraser Stoddart, Michael R Wasielewski
Crystalline supramolecular frameworks consisting of charged molecules, held together by hydrogen bonds and Coulomb interactions, have attracted great interest because of their unusual structural, chemical, electronic and magnetic properties. Herein, we report the preparation, structure and magnetic properties of the triradical trianion of a shape-persistent chiral equilateral molecular triangle having three naphthalene-1,4:5,8-bis(dicarboximide)s ((+)-NDI-(Δ3(-•))). Single-crystal X-ray diffraction of its tris(cobaltocenium) salt ([(+)-NDI--(Δ3(-•))(CoCp2(+))(3)]) reveals accessible one-dimensional tubular cavities, and variable-temperature electron paramagnetic resonance (EPR) spectroscopy shows that a dilute solution of [(+)-NDI--(Δ3(-•))(CoCp2(+))(3)] in an organic glass has a spin-frustrated doublet ground state and a thermally accessible quartet state...
February 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28193105/a-qualitative-analysis-of-information-sharing-in-hospice-interdisciplinary-group-meetings
#19
Karla T Washington, George Demiris, Debra Parker Oliver, Jeffrey A Swarz, Alexandria M Lewis, Uba Backonja
BACKGROUND: In the United States, hospice agencies are required to convene interdisciplinary group (IDG) meetings no less frequently than every 15 days to review patients' care plans. Challenges associated with information sharing during these meetings can impede efficiency and frustrate attendees. OBJECTIVES: We sought to examine information sharing in the context of hospice IDG meetings as a first step toward developing an informatics tool to support interdisciplinary collaboration in this setting...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28190701/parental-perception-and-factors-associated-with-treatment-strategies-for-primary-nocturnal-enuresis
#20
Thomson T Tai, Brent T Tai, Yu-Jun Chang, Kuo-Hsuan Huang
OBJECTIVE: The aim was to investigate the factors influencing parents seeking reasonable managements for their child and their overall outlook toward primary nocturnal enuresis (PNE). STUDY DESIGN: We recruited 93 children with PNE from enuresis clinics and requested their parents to complete questionnaires regarding their child's medical history and behavior, their methods for coping with PNE, and their perception of enuresis. Logistic regression models were applied to investigate factors influencing the parents to adopt a positive approach toward enuresis and to subsequently seek a medical consultation...
January 30, 2017: Journal of Pediatric Urology
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