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https://www.readbyqxmd.com/read/28818556/receptor-binding-kinetics-equations-derivation-using-the-laplace-transform-method
#1
Sam R J Hoare
INTRODUCTION: Measuring unlabeled ligand receptor binding kinetics is valuable in optimizing and understanding drug action. Unfortunately, deriving equations for estimating kinetic parameters is challenging because it involves calculus; integration can be a frustrating barrier to the pharmacologist seeking to measure simple rate parameters. Here, a well-known tool for simplifying the derivation, the Laplace transform, is applied to models of receptor-ligand interaction. The method transforms differential equations to a form in which simple algebra can be applied to solve for the variable of interest, for example the concentration of ligand-bound receptor...
August 14, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28818270/the-glass-ceiling-a-biological-phenomenon
#2
Tom W J Schulpen
Many brilliant and ambitious young women lose their drive for top careers after childbirth. New maternal impulses are at odds with their original ambitions and for many mothers stress and frustration will be the result as they have to combine child care with workweeks of 60-80h to reach or remain at the top. Pregnancy hormones modify the female's brain as has been demonstrated already for decades in animals. This brain plasticity due to adult neurogenesis in the so called maternal circuitry of the limbic system is long-lasting and perhaps lifelong...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28818252/origins-of-cancer-disparities-in-young-adults-logic-models-to-guide-research
#3
Robert A Hiatt, Margaret A Handley, Pamela M Ling, Esteban Burchard, Neeta Thakur, Kirsten Bibbins-Domingo
Cancer disparities research is motivated by persistent inequities in cancer outcomes by race, ethnicity, social status, neighborhood location, and other subpopulation characteristics. These inequities have proven to be persistent and difficult to alter. Part of the reason for the frustration with slow progress is a lack of appreciation of the long-term nature of the undertaking. It is highly likely that the disparities observed in adulthood find their origins in young adulthood, if not earlier. A long-term perspective is needed, recognizing that successes may take many years to realize...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28817296/patients-views-on-price-shopping-and-price-transparency
#4
Hannah L Semigran, Rebecca Gourevitch, Anna D Sinaiko, David Cowling, Ateev Mehrotra
OBJECTIVES: Driven by the growth of high deductibles and price transparency initiatives, patients are being encouraged to search for prices before seeking care, yet few do so. To understand why this is the case, we interviewed individuals who were offered access to a widely used price transparency website through their employer. STUDY DESIGN: Qualitative interviews. METHODS: We interviewed individuals enrolled in a preferred provider organization product through their health plan about their experience using the price transparency tool (if they had done so), their past medical experiences, and their opinions on shopping for care...
June 1, 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28817253/cuts-guided-deterministic-buckling-in-arrays-of-soft-parallel-plates-for-multifunctionality
#5
Gaojian Lin, Dengteng Ge, Yichao Tang, Yu Xia, Gaoxiang Wu, Lin Han, Shu Yang, Jie Yin
Harnessing buckling instability in soft materials offers an effective strategy to achieve multifunctionality. Despite great efforts in controlling the wrinkling behaviors of film-based systems and buckling of periodic structures, the benefits of classical plate buckling in soft materials remain largely unexplored. The challenge lies in the intrinsic indeterminate characteristics of buckling, leading to geometric frustration and random orientations. Here, we report the controllable global order in constrained buckling of arrays of parallel plates made of hydrogels and elastomers on rigid substrates...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28816256/budget-cuts-fuel-frustration-among-japan-s-academics
#6
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
August 14, 2017: Nature
https://www.readbyqxmd.com/read/28813602/carbodicarbenes-unexpected-%C3%AF-accepting-ability-during-re-activity-with-small-molecules
#7
Wen-Ching Chen, Wei-Chih Shih, Titel Jurca, Lili Zhao, Diego M Andrada, Chun-Jung Peng, Chun-Chi Chang, Shu-Kai Liu, Yi-Ping Wang, Yuh-Sheng Wen, Glenn P A Yap, Chao-Ping Hsu, Gernot Frenking, Tiow-Gan Ong
An investigation of carbodicarbenes, the less explored member of the carbenic complex/ligand family has yielded unexpected electronic features and concomitant reactivity. Observed 1,2-addition of E-H bonds (E = B, C, Si) across the carbone central carbon and that of the flanking NHC fragment, combined with single-crystal X-ray studies of a model Pd complex strongly suggests a significant level of π-accepting ability at the central carbon of the NHC moiety. This feature is atypical of classic NHCs, which are strong σ-donors, with only nominal π-accepting ability...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28812858/reducing-frustration-and-increasing-fulfillment-mindfulness
#8
Jay Winner
No abstract text is available yet for this article.
July 2017: Family Practice Management
https://www.readbyqxmd.com/read/28812513/how-to-convince-yourself-you-ve-got-what-it-takes
#9
Mandy Day-Calder
After submitting a job application, you must of course wait to hear if you have passed the first hurdle. It can be a frustrating period but there's nothing you can do to alter this outcome.
August 16, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28808359/electronic-health-records-and-improved-patient-care-opportunities-for-applied-psychology
#10
Raj Ratwani
Healthcare is undergoing an unprecedented technology transition from paper medical records to electronic health records (EHRs). While the adoption of EHRs holds tremendous promise for improving efficiency, quality and safety, there have been numerous challenges that have been largely centered on the technology not meeting the cognitive needs of the clinical end-users. Clinicians are experiencing increased stress and frustration, and new safety hazards have been introduced. There is a significant opportunity for applied psychologists to address many of these challenges...
August 2017: Current Directions in Psychological Science
https://www.readbyqxmd.com/read/28807959/referral-processes-and-wait-times-in-primary-care
#11
Ieva Neimanis, Kathryn Gaebel, Robert Dickson, Richard Levy, Cindy Goebel, Angelo Zizzo, Anne Woods, John Corsini
OBJECTIVE: To evaluate the response times to requests for consultations from FPs and the wait times for patient appointments. DESIGN: Mailed invitation to participate in a survey about non-FP specialist consultation requests from April 28 to May 9, 2014. SETTING: Hamilton, Ont. PARTICIPANTS: All active physicians with community practices from the Department of Family Medicine at St Joseph's Healthcare Hamilton and Hamilton Health Sciences...
August 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28806278/ce-original-research-the-experience-of-transitioning-to-a-caregiving-role-for-a-family-member-with-alzheimer-s-disease-or-related-dementia
#12
Kathleen Czekanski
Study findings suggest several areas for further research. ABSTRACT: Background: Alzheimer's disease is a chronic, debilitating disease that currently affects an estimated 5.5 million Americans. The majority are being cared for at home by family caregivers, who are known to have higher levels of burden than any other group of caregivers. PURPOSE: The purpose of this phenomenological study was to explore the lived experiences of people who transition to the role of caregiver for a family member with Alzheimer's disease or a related dementia...
August 10, 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28805718/myoclonic-disorders
#13
REVIEW
Olaf Eberhardt, Helge Topka
Few movement disorders seem to make a straightforward approach to diagnosis and treatment more difficult and frustrating than myoclonus, due to its plethora of causes and its variable classifications. Nevertheless, in recent years, exciting advances have been made in the elucidation of the pathophysiology and genetic basis of many disorders presenting with myoclonus. Here, we provide a review of all of the important types of myoclonus encountered in pediatric and adult neurology, with an emphasis on the recent developments that have led to a deeper understanding of this intriguing phenomenon...
August 14, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28803562/dopamine-receptor-d2-drd2-dopamine-transporter-solute-carrier-family-c6-member-4-slc6a3-and-catechol-o-methyltransferase-comt-genes-as-moderators-of-the-relation-between-maternal-history-of-maltreatment-and-infant-emotion-regulation
#14
Vanessa Villani, Jaclyn Ludmer, Andrea Gonzalez, Robert Levitan, James Kennedy, Mario Masellis, Vincenzo S Basile, Christine Wekerle, Leslie Atkinson
Although infants less than 18 months old are capable of engaging in self-regulatory behavior (e.g., avoidance, withdrawal, and orienting to other aspects of their environment), the use of self-regulatory strategies at this age (as opposed to relying on caregivers) is associated with elevated behavioral and physiological distress. This study investigated infant dopamine-related genotypes (dopamine receptor D2 [DRD2], dopamine transporter solute carrier family C6, member 4 [SLC6A3], and catechol-O-methyltransferase [COMT]) as they interact with maternal self-reported history of maltreatment to predict observed infant independent emotion regulation behavior...
August 14, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28803557/altered-intrinsic-functional-connectivity-of-the-cingulate-cortex-in-children-with-severe-temper-outbursts
#15
Amy Krain Roy, Randi Bennett, Jonathan Posner, Leslie Hulvershorn, F Xavier Castellanos, Rachel G Klein
Severe temper outbursts (STO) in children are associated with impaired school and family functioning and may contribute to negative outcomes. These outbursts can be conceptualized as excessive frustration responses reflecting reduced emotion regulation capacity. The anterior cingulate cortex (ACC) has been implicated in negative affect as well as emotional control, and exhibits disrupted function in children with elevated irritability and outbursts. This study examined the intrinsic functional connectivity (iFC) of a region of the ACC, the anterior midcingulate cortex (aMCC), in 5- to 9-year-old children with STO (n = 20), comparing them to children with attention-deficit/hyperactivity disorder (ADHD) without outbursts (ADHD; n = 18)...
August 14, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28802475/integrative-pain-management
#16
REVIEW
Robert Alan Bonakdar
Chronic pain is one of the most common conditions seen in the clinic, and it is often one of the most frustrating for both clinicians and patients. This condition stems from common comorbidities, including depression, insomnia, fatigue, and physical deconditioning, which often create barriers to recovery. In addition, chronic pain has had divergent approaches for treatment, including an overemphasis on analgesia and curative treatments while underemphasizing the biopsychosocial needs of those in pain. This article attempts to provide an initial framework for approaching those in pain and initiating patient-centered options to support improvements in pain, function, and self-care...
September 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28801082/-how-to-videos-improve-residents-performance-of-essential-perioperative-electronic-medical-records-and-clinical-tasks
#17
Veronica Zoghbi, Robert C Caskey, Kristoffel R Dumon, Jacqueline M Soegaard Ballester, Ari D Brooks, Jon B Morris, Daniel T Dempsey
OBJECTIVE: The ability to use electronic medical records (EMR) is an essential skill for surgical residents. However, frustration and anxiety surrounding EMR tasks may detract from clinical performance. We created a series of brief, 1-3 minutes "how to" videos demonstrating 7 key perioperative EMR tasks: booking OR cases, placing preprocedure orders, ordering negative-pressure wound dressing supplies, updating day-of-surgery history and physical notes, writing brief operative notes, discharging patients from the postanesthesia care unit, and checking vital signs...
August 8, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28800796/difficult-patients-in-the-emergency-department-personality-disorders-and-beyond
#18
REVIEW
Nidal Moukaddam, Araceli Flores, Anu Matorin, Nicholas Hayden, Veronica Theresa Tucci
Physician-patient encounters in clinical settings, especially in the emergency department, can be of varying degrees of difficulty. Medically complicated, challenging cases can be paradoxically rewarding, whereas psychologically driven difficulty is frustrating and counterproductive for patient care. This article presents 3 different complementary perspectives on difficult patients: clinical presentations, manifestations of personality traits and disorders in clinical settings, and how physician feelings may affect care...
September 2017: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28799474/-caught-between-a-rock-and-a-hard-place-between-discourses-of-empowerment-and-solicitude-danish-public-sector-service-professionals-discourses-of-nonattendance
#19
Michaela Hoej, Katrine Schepelern Johansen, Birgitte Ravn Olesen, Sidse Marie Arnfred
Nonattendance constitutes a profound challenge in public sector services targeting young adults with mental health difficulties. Therefore, researchers and practitioners are occupied with trying to resolve this. For clinicians to be aware of their own naturalized and perhaps inappropriate communicative practices, we investigated the established normative organizational logics behind explanations and strategies related to nonattendance. We performed a critical discourse analysis on material collected through participatory research throughout 2015...
September 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28799081/the-psychosocial-impact-of-carrying-a-debated-variant-in-the-gla-gene
#20
Sarah Macklin, Dawn Laney, Emily Lisi, Andrea Atherton, Elizabeth Smith
The clinical significance of the c.427G>A (p.A143T) variant in GLA is a topic of debate within the lysosomal storage disease community. A review of the literature and published case reports found the clinical impact of the variant to range from classic Fabry symptoms to healthy unaffected males with normal alpha- galactosidase enzyme levels, leaving clinicians unsure of how to manage these individuals. As the number of states testing for Fabry disease on their newborn screening panel has increased, more people with this variant are being identified...
August 10, 2017: Journal of Genetic Counseling
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