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https://www.readbyqxmd.com/read/29349008/meniscal-allograft-transplantation-made-simple-bridge-and-slot-technique
#1
Daniel J Kaplan, Sergio A Glait, William E Ryan, Michael J Alaia, Kirk A Campbell, Eric J Strauss, Laith M Jazrawi
Over recent years, appreciation for the critical role of the meniscus in joint biomechanics has led to an emphasis on meniscal preservation. Meniscal allograft transplant (MAT) is a promising biological solution for the symptomatic young patient with a meniscus-deficient knee that has not developed advanced osteoarthritis. As surgical techniques are refined and outcomes continue to improve, it is vital to consider the utility of such procedures and offer a straightforward approach to MAT. This article and accompanying video provide a step-by-step tutorial on how to perform a MAT using the bridge and slot technique, its key pearls and pitfalls as well as the relevant advantages and disadvantages of MAT...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29345622/position-paper-on-nasal-obstruction-evaluation-and-treatment
#2
REVIEW
A Valero, A M Navarro, A Del Cuvillo, I Alobid, J R Benito, C Colás, G de Los Santos, R Fernández Liesa, A García-Lliberós, R González-Pérez, A Izquierdo-Domínguez, A Jurado-Ramos, M M Lluch-Bernal, J R Montserrat Gili, J Mullol, A Puiggròs Casas, M C Sánchez-Hernández, F Vega, J M Villacampa, M Armengot-Carceller, M T Dordal
Nasal obstruction (NO) is defined as the subjective perception of discomfort or difficulty in the passage of air through the nostrils. It is a common reason for consultation in primary and specialized care, and it may affect up to 30-40% of the population. It affects the quality of life (it especially disturbs sleep) and lowers work efficiency. The aim of this document is to agree on how to treat NO, establish a methodology for evaluating and diagnosing it, and define an individualized approach to its treatment...
January 18, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29334764/development-of-gene-therapeutics-for-head-and-neck-cancer-in-china-from-bench-to-bedside
#3
Wei Guo, Hao Song
Head and neck cancer represents the seventh most common cancer worldwide. Multidisciplinary sequential treatment was performed in patients with head and neck cancer. However, there is an urgent need for a new treatment approach that can effectively improve the outcomes of head and neck cancer patients with advanced stage. Gene therapy is a rapidly evolving field with head and neck cancer. It has been proved a promising way to improve the efficacy of antitumor treatment. China is at the forefront in clinical trials and practice of gene therapies in the world...
January 15, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29324741/facilitating-healthcare-decisions-by-assessing-the-certainty-in-the-evidence-from-preclinical-animal-studies
#4
Carlijn R Hooijmans, Rob B M de Vries, Merel Ritskes-Hoitinga, Maroeska M Rovers, Mariska M Leeflang, Joanna IntHout, Kimberley E Wever, Lotty Hooft, Hans de Beer, Ton Kuijpers, Malcolm R Macleod, Emily S Sena, Gerben Ter Riet, Rebecca L Morgan, Kristina A Thayer, Andrew A Rooney, Gordon H Guyatt, Holger J Schünemann, Miranda W Langendam
Laboratory animal studies are used in a wide range of human health related research areas, such as basic biomedical research, drug research, experimental surgery and environmental health. The results of these studies can be used to inform decisions regarding clinical research in humans, for example the decision to proceed to clinical trials. If the research question relates to potential harms with no expectation of benefit (e.g., toxicology), studies in experimental animals may provide the only relevant or controlled data and directly inform clinical management decisions...
2018: PloS One
https://www.readbyqxmd.com/read/29279556/lymphangiography-was-useful-in-postoperative-intractable-chylothorax-after-surgery-for-esophageal-cancer-a-case-report
#5
Takeshi Shimakawa, Yoshihiko Naritaka, Miki Miyazawa, Shinichi Asaka, Asako Shimazaki, Kentaro Yamaguchi, Hajime Yokomizo, Kazuhiko Yoshimatsu, Shunichi Shiozawa, Takao Katsube
Postoperative chylothorax after surgery for esophageal cancer is a rare but serious complication. Treatment initially consists of conservative therapy and, if it fails to provide improvement, it is important to perform surgical treatment without delay. We report on a recent case of intractable chylothorax. This report describes a 72-year-old man with Stage III esophageal squamous cell carcinoma. Subtotal esophagectomy, through a right thoracoabdominal approach with two-field lymphadenectomy, and cervical esophagogastric anastomosis via the retrosternal route, were performed...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29278223/understanding-the-system-you-are-in-is-key-to-improving-it
#6
Paul Plsek
Front-line ownership (FLO) is an approach to change that is consistent with what we know about complex adaptive systems (CAS), such as a healthcare organization. Traditional change approaches can fail because they are based in the "organization as a machine" metaphor of traditional, scientific management. Both metaphors have their application. It depends on how closely the work naturally resembles a predictable machine. Often, the drive for detailed standardization is a misguided effort to make a human CAS behave more like a machine, so that our traditional approaches to change will work...
2017: HealthcarePapers
https://www.readbyqxmd.com/read/29276278/critical-appraisal-of-biomedical-literature-with-a-succinct-journal-club-template-the-roots-format
#7
Ashley Johnson, Krisy-Ann Thornby, Mary Ferrill
Journal clubs are a valuable tool to assist pharmacists in the evaluation of biomedical literature and to promote adoption of evidence-based practices. The concise ROOTs (relevance, observe validity, obtain clinically significant results, and translate results to clinical practice) method was developed to help simplify and provide structure to any journal club process. Although there are a variety of recommended practices on how to conduct journal clubs using a variety of questions and checklists, many are cumbersome and difficult to complete and present in less than 30 minutes...
July 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29275557/-forensic-analysis-of-63-cases-of-non-violent-death-occurred-in-custody
#8
S M Yang, Y B Cheng
OBJECTIVES: To collect cases of non-violent death occurred in custody for analyzing the forensic characteristics and related influencing factors. METHODS: Sixty-three cases of non-violent death among detainees in custody that handled by a forensic science center from 2000 to 2015 were collected. The type, onset season, medical history, clinical manifestation, treatment and duration of related fatal diseases were analyzed retrospectively. RESULTS: The deaths due to diseases in custody were common in male, and with a high incidence in middle aged adults...
October 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29240335/caring-communication-the-impact-of-interpersonal-communication-between-physician-and-patient-can-smileys-measure-the-quality-of-communication
#9
Harry Köhler, Päivi Rautava, Ville Vuorinen
The importance of communication in medical practice is widely recognized, but what is good communication in patient encounter? Feedback and surveys based on patient experience or "smileys" provide a narrow and often too insignificant view of communication. In addition to patient experience, communication benefits the information gathering by the physician and the patient, the patient's ability to promote his/her recovery, the physician's coping with workload, and the effectiveness of health care. In order to evaluate communication and improve it, one has to recognize the criteria and objectives of good communication...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29236241/set-organic-pollution-as-an-impact-category-to-achieve-more-comprehensive-evaluation-of-life-cycle-assessment-in-wastewater-related-issues
#10
Xinyue Zhao, Jixian Yang, Fang Ma
For wastewater-related issues (WRI), life cycle assessment (LCA) is often used to evaluate environmental impacts and derive optimization strategies. To promote the application of LCA for WRI, it is critical to incorporate local impact of water pollutants. Organic pollution, a main type of water pollution, has not been given much consideration in current LCA systems. This paper investigates the necessity of setting a regionalized impact category to reflect the local impact of organic pollution. A case study is conducted concerning an upgraded wastewater treatment plant (WWTP) in China, which is assumed to meet different sewage control strategies...
December 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29234929/can-thyromental-distance-be-measured-accurately
#11
Bin Wang, Hui Peng, Weidong Yao, Ling Guo, Xiaoju Jin
Using the thyromental distance (TMD) measured based on the ultrasonographic location of the thyroid cartilage prominence as the criterion, we investigated the accuracy of TMD measurement by surface landmark identification of the thyroid cartilage prominence. Twenty-nine anesthetist resident volunteers were recruited, including 10 first-year residents, 9 second-year residents and 10 third-year residents. Each volunteer measured the other 28 volunteers' TMD. Then, the thyroid cartilage prominence of each volunteer was identified by ultrasonography of the junction of the vocal cord and thyroid cartilage, and the TMD was measured precisely...
December 12, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29218921/machine-learning-and-deep-analytics-for-biocomputing-call-for-better-explainability
#12
Dragutin Petkovic, Lester Kobzik, Christopher Re
The goals of this workshop are to discuss challenges in explainability of current Machine Leaning and Deep Analytics (MLDA) used in biocomputing and to start the discussion on ways to improve it. We define explainability in MLDA as easy to use information explaining why and how the MLDA approach made its decisions. We believe that much greater effort is needed to address the issue of MLDA explainability because of: 1) the ever increasing use and dependence on MLDA in biocomputing including the need for increased adoption by non-MLD experts; 2) the diversity, complexity and scale of biocomputing data and MLDA algorithms; 3) the emerging importance of MLDA-based decisions in patient care, in daily research, as well as in the development of new costly medical procedures and drugs...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29216874/factors-influencing-the-experience-of-sexual-and-reproductive-healthcare-for-female-adolescents-with-perinatally-acquired-hiv-a-qualitative-case-study
#13
Gertrude Mwalabu, Catrin Evans, Sarah Redsell
BACKGROUND: Young people living with perinatally-acquired HIV require age-appropriate support regarding sex and relationships as they progress towards adulthood. HIV affects both genders but evidence suggests that young women are particularly vulnerable to sexual abuse and more prone to engaging in sexual behaviours to meet their daily survival needs. This can result in poor sexual and reproductive health (SRH) outcomes. HIV services in Malawi provide support for young women's HIV-related clinical needs, but it is unclear whether there is sufficient provision for their SRH needs as they become adults...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29213250/why-prediction-matters-in-multitasking-and-how-predictability-can-improve-it
#14
Laura Broeker, Andrea Kiesel, Stefanie Aufschnaiter, Harald E Ewolds, Robert Gaschler, Hilde Haider, Stefan Künzell, Markus Raab, Eva Röttger, Roland Thomaschke, Fang Zhao
No abstract text is available yet for this article.
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29212094/-readiness-to-participate-in-ambulatory-special-medical-care-asv-a-critical-appraisal-results-of-a-survey-amongst-office-based-oncologists-in-germany
#15
Robert Dengler, Thomas Walawgo, Walter Baumann, Manfred Cassens
Background Outpatient specialized care (ASV) is intended to improve interdisciplinary, transsectoral care for patients with rare or complex diseases, especially cancer. Up to now, only very few such specialized care teams have been established. The aim of our study was to evaluate the current state of information and participation as well as reasons for the reluctance of office-based hematologists and oncologists. Methods We conducted a web-based survey amongst office-based hematologists and oncologists in Germany and received responses from 145 institutions comprising more then 350 doctors working there...
December 6, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29203760/developing-a-framework-for-evaluating-the-impact-of-healthcare-improvement-science-education-across-europe-a-qualitative-study
#16
Manuel Lillo-Crespo, M Cristina Sierras-Davó, Rhoda MacRae, Kevin Rooney
Purpose: Frontline healthcare professionals are well positioned to improve the systems in which they work. Educational curricula, however, have not always equipped healthcare professionals with the skills or knowledge to implement and evaluate improvements. It is important to have a robust and standardized framework in order to evaluate the impact of such education in terms of improvement, both within and across European countries. The results of such evaluations will enhance the further development and delivery of Healthcare Improvement Science (HIS) education...
November 29, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/29194566/national-screening-guidelines-and-developments-in-prenatal-diagnoses-and-live-births-of-down-syndrome-in-the-period-1973-2016-in-denmark
#17
Stina Lou, Olav Bjørn Petersen, Finn Stener Jørgensen, Ida Charlotte Bay Lund, Susanne Kjaergaard, Ida Vogel
Denmark was the first country in the world to implement a national, free-for-all offer of prenatal screening for Down syndrome to all pregnant women. It has a high uptake (> 90%) compared to other countries. Thus, Denmark offers an interesting case for investigating the consequences of implementing a comprehensive, national prenatal screening guideline. The aim of this study was to describe the historical developments in invasive procedures, pre-/postnatal diagnoses of Down syndrome and Down syndrome live births in the period 1973-2016 in Denmark MATERIAL AND METHODS: Data on invasive procedures, pre- and postnatal Down syndrome diagnoses were retrieved from the Danish Cytogenetic Central Registry RESULTS: From 1973-1993 screening based on maternal age and high-risk indications resulted in a constant increase in invasive procedures...
December 1, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29184854/oncolytic-virus-delivery-from-nano-pharmacodynamics-to-enhanced-oncolytic-effect
#18
REVIEW
Raquel Yokoda, Bolni M Nagalo, Brent Vernon, Rahmi Oklu, Hassan Albadawi, Thomas T DeLeon, Yumei Zhou, Jan B Egan, Dan G Duda, Mitesh J Borad
With the advancement of a growing number of oncolytic viruses (OVs) to clinical development, drug delivery is becoming an important barrier to overcome for optimal therapeutic benefits. Host immunity, tumor microenvironment and abnormal vascularity contribute to inefficient vector delivery. A number of novel approaches for enhanced OV delivery are under evaluation, including use of nanoparticles, immunomodulatory agents and complex viral-particle ligands along with manipulations of the tumor microenvironment...
2017: Oncolytic Virotherapy
https://www.readbyqxmd.com/read/29169983/novel-proctorship-effectively-teaches-interventionists-coronary-artery-chronic-total-occlusion-lesions
#19
Masanori Yamamoto, Etsuo Tsuchikane, Ai Kagase, Tetsuro Shimura, Tomohiko Teramoto, Masashi Kimura, Hitoshi Matsuo, Yoshiaki Kawase, Yoriyasu Suzuki, Seiji Kano, Maoto Habara, Kenya Nasu, Yoshihisa Kinoshita, Mitsuyasu Terashima, Tetsuo Matsubara, Takahiko Suzuki
BACKGROUND: Interventionists' experience and skills are essential factors for successful chronic total occlusion-percutaneous coronary intervention (CTO-PCI). However, the construction of theoretical strategy independent from interventionists' procedure may also improve it. We sought to assess the feasibility of CTO-PCI using an educational system supported by a single expert proctor. METHODS: A total of 160 patients underwent CTO-PCI between 2009 and 2016 at 92 Japanese centers in the Hands-on proctorship project...
October 26, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29167609/the-application-and-future-of-big-database-studies-in-cardiology-a-single-center-experience
#20
REVIEW
Kuang-Tso Lee, Ai-Ling Hour, Ben-Chang Shia, Pao-Hsien Chu
As medical research techniques and quality have improved, it is apparent that cardiovascular problems could be better resolved by more strict experiment design. In fact, substantial time and resources should be expended to fulfill the requirements of high quality studies. Many worthy ideas and hypotheses were unable to be verified or proven due to ethical or economic limitations. In recent years, new and various applications and uses of databases have received increasing attention. Important information regarding certain issues such as rare cardiovascular diseases, women's heart health, post-marketing analysis of different medications, or a combination of clinical and regional cardiac features could be obtained by the use of rigorous statistical methods...
November 2017: Acta Cardiologica Sinica
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