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https://www.readbyqxmd.com/read/28106574/walking-ability-of-spinal-cord-injury-individuals-how-to-improve-it
#1
Morteza Sadeghi, Gholam Hussein Ghasemi, Mohammad Taghi Karimi
BACKGROUND: Subjects with Spinal Cord Injury (SCI) should use various assistive devices to stand and walk. Unfortunately they suffer from slow walking speed, high energy consumption, and too much force applied on upper limb while walking. The aim of this study was to determine the gap between the gait performance of SCI and normal subjects to conclude how the performance of SCI can be improved. METHOD: Three groups of SCI walked with orthosis, SCI walked without orthosis, and normal subjects were recruited in this study...
January 13, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28099208/the-upside-down-world-of-diabetes-care-medical-economics-and-what-we-might-do-to-improve-it
#2
David M Harlan, Irl B Hirsch
PURPOSE OF REVIEW: Increasingly over the past generation, the American healthcare delivery system has received consistently poor marks with regard to public health outcomes and costs. This review by two seasoned diabetes care providers is intended to shed light on the fundamental flaws we believe to underlie that poor performance, and suggest options for better outcomes and cost efficiencies. RECENT FINDINGS: Despite major advances in diabetes management medications and tools, overall public health with regard to diabetes outcomes remains poor...
January 17, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28092725/strontium-ranelate-a-promising-disease-modifying-osteoarthritis-drug
#3
Weiyu Han, Shicai Fan, Xiaochun Bai, Changhai Ding
The articular cartilage and subchondral bone may have potential crosstalk in the development and progression of osteoarthritis (OA). Strontium ranelate (SrR) has the ability to dissociate the bone remodeling process and to change the balance between bone resorption and bone formation. Its effect on subchondral bone makes it a potential disease- modifying osteoarthritis drug (DMOAD) in the treatment of OA. The aim of the current review is to summarize up-to-date pharmacological and clinical data of SrR for OA treatment...
January 16, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28090731/addition-of-ezetimibe-to-statins-for-patients-at-high-cardiovascular-risk-systematic-review-of-patient-important-outcomes
#4
REVIEW
Yutong Fei, Gordon Henry Guyatt, Paul Elias Alexander, Regina El Dib, Reed A C Siemieniuk, Per Olav Vandvik, Mark E Nunnally, Huda Gomaa, Rebecca L Morgan, Arnav Agarwal, Ying Zhang, Neera Bhatnagar, Frederick A Spencer
Ezetimibe is widely used in combination with statins to reduce low-density lipoprotein. We sought to examine the impact of ezetimibe when added to statins on patient-important outcomes. Medline, EMBASE, CINAHL, and CENTRAL were searched through July, 2016. Randomized controlled trials (RCTs) of ezetimibe combined with statins versus statins alone that followed patients for at least 6 months and reported on at least one of all-cause mortality, cardiovascular deaths, non-fatal myocardial infarctions (MI), and non-fatal strokes were included...
January 16, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28071928/recent-advancements-in-lateral-flow-immunoassays-a-journey-for-toxin-detection-in-food
#5
Pranav Tripathi, Neha Upadhyay, Seema Nara
Biotechnology embraces various physical and chemical phenomenon towards advancement of health diagnostics. Towards such advancement, detection of toxins play an important role. Toxins produce severe health impacts on consumption with high mortality associated in acute cases. The most prominent route of infection and intoxication is through food matrices. Therefore, rapid detection of toxins at low concentrations is the need of modern diagnostics. Lateral flow immunoassays are one of the emergent and popularly used rapid detection technology developed for detecting various kinds of analytes...
January 10, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28061985/multiple-myeloma-epidemiology-and-survival-a-unique-malignancy
#6
REVIEW
Dickran Kazandjian
Multiple myeloma (MM), although a rare disease, is the second most common hematologic malignancy. It is found in the spectrum of plasma cell dyscrasias, which begins with monoclonal gammopathy of unknown significance (MGUS) to overt plasma cell leukemia and extramedullary myeloma. MM is associated with significant morbidity due to its end-organ destruction. It is a disease of the older population and its incidence in the African American population is twice that of the European American population. Improvements in the treatment of MM in the past couple of decades, beginning with the use of autologous stem cell transplantation followed by availability of novel treatments such as immunomodulatory drugs (ImIDs) and proteasome inhibitors (PIs) has transformed the natural history of the disease leading to longer survival times...
December 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/28049820/on-demand-high-capacity-ride-sharing-via-dynamic-trip-vehicle-assignment
#7
Javier Alonso-Mora, Samitha Samaranayake, Alex Wallar, Emilio Frazzoli, Daniela Rus
Ride-sharing services are transforming urban mobility by providing timely and convenient transportation to anybody, anywhere, and anytime. These services present enormous potential for positive societal impacts with respect to pollution, energy consumption, congestion, etc. Current mathematical models, however, do not fully address the potential of ride-sharing. Recently, a large-scale study highlighted some of the benefits of car pooling but was limited to static routes with two riders per vehicle (optimally) or three (with heuristics)...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28034813/is-first-line-vancomycin-still-the-best-option-to-treat-staphylococcus-health-care-associated-meningitis
#8
Roman Mounier, David Lobo, Anne Hulin, Biba Nebbad, Fabrice Cook, Gilles Dhonneur
BACKGROUND: Cerebrospinal fluid (CSF) penetration of vancomycin through the blood-brain barrier is poor but important inflammation improved it. Hence, vancomycin is recommended for the treatment of community meningitis. However, what about mild inflammatory health care-associated meningitis? The aim of this study was to evaluate the impact of vancomycin diffusion on CSF in Staphylococcus epidermidis health care-associated meningitis. CASE DESCRIPTION: This was a retrospective study of all consecutive patients with S...
December 27, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28024491/-children-s-nk-t-cell-lymphoma-associated-hemophagocytic-syndrome-clinical-analysis-of-6-cases
#9
Yong-Zhi Zheng, Hao Zheng, Jian Li, Shao-Hua LE, Xue-Ling Hua, Zai-Sheng Chen, Ling Zheng, Mei Li, Yi-Qiao Chen, Qin-Li Gao, Jing-Hui Yang, Jian-Da Hu
OBJECTIVE: To study the clinical features, treatment and prognosis of patients with NK/T cell lymphoma-associated hemophagocytic syndrome(NK/T-LAHPS). METHODS: Retrospective analysis was used to explore the clinical data of 6 children with NK/T-LAHPS who were admitted in Department of Pediatric Hematology of Fujian Medical University Union Hospital from July 2012 to June 2016. The 6 patients included 4 boys and 2 girls, with a median age of 4 years(range 1.75 to 11)...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28019114/-lipids-and-cerebrovascular-disease-new-therapeutic-options-in-lowering-ldl-cholesterol
#10
Emese Lovadi, Péter Csécsei, Csenge Lovig, Zsófia Karádi, László Szapáry
Stroke is the third most common cause of death worldwide following myocardial infaction and malignancies, furthermore, its functional outcome is the worst of all conditions. Cholesterol, especially LDL-cholesterol plays a key role in the formation of atherosclerotic plaques. It has been verified recently that escalating incidence and mortality of cerebrovascular diseases are proportional to increased levels of LDL-cholesterol. Statin therapy undeniably reduces the risk of stroke, however other methods for decreasing lipid levels have not been proved significantly effective...
December 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/28008376/assessment-of-bone-health-in-breast-cancer-patients-starting-adjuvant-aromatase-inhibitors-a-quality-improvement-clinical-audit
#11
Jamal Zekri, Kamel Farag
INTRODUCTION: Adjuvant Aromatase Inhibitors (AIs) predispose breast cancer patients to accelerated bone loss. Guidelines recommend initial screening and follow up of bone mineral density with dual energy X-ray absorptiometry (DEXA) scan. In this audit we assessed the rate of adherence to these guidelines and introduced awareness measures to improve it. METHODS: All post-menopausal women who started upfront adjuvant AIs (letrozole in all patients) between January 2007 and December 2013 were retrospectively identified...
November 2016: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28008217/anticancer-properties-of-baicalein-a-review
#12
Ying Gao, Shane A Snyder, Jaclyn N Smith, Yi Charlie Chen
The constituents of many traditional Chinese herbal remedies are currently at the forefront of modern cancer research. Baicalein, a bioactive flavone widely used in nutraceuticals and pharmaceuticals, has shown great potential in the treatment and prevention of cancer without causing severe side effects. Baicalein induces cancer cell apoptosis and cause cell cycle arrest. It shows inhibitory effects on angiogenesis, metastasis and inflammation, all of which are necessary for the promotion and progression of cancer...
August 2016: Medicinal Chemistry Research
https://www.readbyqxmd.com/read/28004378/evaluation-of-the-dental-curriculum-at-the-university-of-basel-does-the-master-of-dental-medicine-adequately-prepare-for-the-professional-practice
#13
Nicola U Zitzmann, Nadja Yoon-Büchel, Julia Bühler, Christian A Dettwiler, Roland Weiger
The present study reports the results of a structured survey of graduates intending to evaluate the education at the Dental School of the University of Basel in the years from 2006 to 2014. In addition, dentists and practice owners supervising graduates from Basel in daily clinical routine or hiring them as assistant dentists were questioned. The aims of the current survey were (1) to analyze own subjective experiences, (2) to assess potential differences between the cohorts prior to and after the implementation of the Bologna reform, (3) to compare the rating regarding theoretical knowledge and practical skills, and (4) to disclose potential for improvement...
2016: Swiss Dental Journal
https://www.readbyqxmd.com/read/28003636/data-intensive-drug-development-in-the-information-age-applications-of-systems-biology-pharmacology-toxicology
#14
Naoki Kiyosawa, Sunao Manabe
Pharmaceutical companies continuously face challenges to deliver new drugs with true medical value. R&D productivity of drug development projects depends on 1) the value of the drug concept and 2) data and in-depth knowledge that are used rationally to evaluate the drug concept's validity. A model-based data-intensive drug development approach is a key competitive factor used by innovative pharmaceutical companies to reduce information bias and rationally demonstrate the value of drug concepts. Owing to the accumulation of publicly available biomedical information, our understanding of the pathophysiological mechanisms of diseases has developed considerably; it is the basis for identifying the right drug target and creating a drug concept with true medical value...
2016: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28001145/dna-biosensing-with-3d-printing-technology
#15
Adeline Huiling Loo, Chun Kiang Chua, Martin Pumera
3D printing, an upcoming technology, has vast potential to transform conventional fabrication processes due to the numerous improvements it can offer to the current methods. To date, the employment of 3D printing technology has been examined for applications in the fields of engineering, manufacturing and biological sciences. In this study, we examined the potential of adopting 3D printing technology for a novel application, electrochemical DNA biosensing. Metal 3D printing was utilized to construct helical-shaped stainless steel electrodes which functioned as a transducing platform for the detection of DNA hybridization...
December 21, 2016: Analyst
https://www.readbyqxmd.com/read/27981001/capacity-fade-analysis-of-sulfur-cathodes-in-lithium-sulfur-batteries
#16
Jianhua Yan, Xingbo Liu, Bingyun Li
Rechargeable lithium-sulfur (Li-S) batteries are receiving ever-increasing attention due to their high theoretical energy density and inexpensive raw sulfur materials. However, their rapid capacity fade has been one of the key barriers for their further improvement. It is well accepted that the major degradation mechanisms of S-cathodes include low electrical conductivity of S and sulfides, precipitation of nonconductive Li2S2 and Li2S, and poly-shuttle effects. To determine these degradation factors, a comprehensive study of sulfur cathodes with different amounts of electrolytes is presented here...
December 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27969902/tct-535-coronary-computed-tomography-angiography-ccta-blood-flow-model-how-we-can-improve-it-insights-based-on-comparison-with-intravascular-ultrasound-ivus-tridimensional-model
#17
Cristiano Bezerra, Carlos Bulant, Gonzalo Maso Talou, Jose Mariani, Breno Falcão, Fábio Augusto Pinton, Raul Feijóo, Antonio Filho, Pedro Lemos
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27956756/predicting-energy-performance-of-a-net-zero-energy-building-a-statistical-approach
#18
Joshua Kneifel, David Webb
Performance-based building requirements have become more prevalent because it gives freedom in building design while still maintaining or exceeding the energy performance required by prescriptive-based requirements. In order to determine if building designs reach target energy efficiency improvements, it is necessary to estimate the energy performance of a building using predictive models and different weather conditions. Physics-based whole building energy simulation modeling is the most common approach. However, these physics-based models include underlying assumptions and require significant amounts of information in order to specify the input parameter values...
September 2016: Applied Energy
https://www.readbyqxmd.com/read/27938725/-how-do-authors-of-systematic-reviews-restrict-their-literature-searches-when-only-studies-from-germany-should-be-included
#19
REVIEW
Dawid Pieper, Tim Mathes, Rebecca Palm, Falk Hoffmann
INTRODUCTION: The use of search filters (e. g. for study types) facilitates the process of literature searching. Regional limits might be helpful depending on the research question. Regional search filters are already available for some regions, but not for Germany. Our aim is to give an overview of applied search strategies in systematic reviews (SRs) focusing on Germany. METHODS: We searched Medline (via Pubmed) applying a focused search strategy to identify SRs focusing on Germany in January 2016...
November 2016: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/27927495/the-substantial-clinical-benefit-threshold-for-srs-22r-domains-after-surgical-treatment-of-adult-spinal-deformity
#20
Charles H Crawford, Steven D Glassman, Keith H Bridwell, Leah Y Carreon
STUDY DESIGN: Longitudinal cohort. OBJECTIVES: To determine Substantial Clinical Benefit (SCB) thresholds for the SRS22R domains in patients undergoing adult spinal deformity surgery. SUMMARY OF BACKGROUND DATA: The Scoliosis Research Society 22R (SRS22R) has been shown to be reliable, valid, and responsive to change in adult spinal deformity patients. Although the minimal clinically important difference (MCID) is commonly used to quantify a threshold of improvement, it could be considered a floor value rather than a goal...
September 2016: Spine Deformity
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