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https://www.readbyqxmd.com/read/29143393/an-algorithm-to-detect-unexpected-increases-in-frequency-of-reports-of-adverse-events-in-eudravigilance
#1
Luis C Pinheiro, Gianmario Candore, Cosimo Zaccaria, Jim Slattery, Peter Arlett
PURPOSE: The European Medicines Agency developed an algorithm to detect unexpected increases in frequency of reports, to enhance the ability to detect adverse events that manifest as increases in frequency, in particular quality defects, medication errors, and cases of abuse or misuse. METHODS: An algorithm based on a negative binomial time-series regression model run on 6 sequential observations prior to the monitored period was developed to forecast monthly counts of reports...
November 16, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29133435/coordinated-plasticity-of-synapses-and-astrocytes-underlies-practice-driven-functional-vicariation-in-peri-infarct-motor-cortex
#2
Soo Young Kim, J Edward Hsu, Lincoln C Husbands, Jeffrey A Kleim, Theresa A Jones
Motor rehabilitative training after stroke can improve motor function and promote topographical reorganization of remaining motor cortical movement representations, but this reorganization follows behavioral improvements. A more detailed understanding of the neural bases of rehabilitation efficacy is needed to inform therapeutic efforts to improve it. Using a rat model of upper extremity impairments after ischemic stroke, we examined effects of motor rehabilitative training at the ultrastructural level in peri-infarct motor cortex...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29119957/-the-psychological-security-in-the-framework-of-the-system-of-factors-responsible-for-the-effectiveness-of-spa-and-health-resort-based-rehabilitation
#3
T M Krasnyanskaya, V G Tylets
AIM: The present work was designed to address the problem of ensuring the psychological security in the framework of organization of the rehabilitative treatment based at the spa and health resort facilities. MATERIAL AND METHODS: We undertook the questionnaire study for which 650 subjects were recruited among those attending spa and health resort facilities of the cities of Essentuki and Kislovodsk. The participants were asked to estimate the level of their personal security and the quality of the provided means for the rehabilitative treatment and general health improvement...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29119473/preference-of-oral-tenofovir-disoproxil-fumarate-emtricitabine-versus-rectal-tenofovir-reduced-glycerin-1-gel-regimens-for-hiv-prevention-among-cisgender-men-and-transgender-women-who-engage-in-receptive-anal-intercourse-with-men
#4
Alex Carballo-Diéguez, Rebecca Giguere, Curtis Dolezal, Cheng-Shiun Leu, Iván C Balán, William Brown, Christine Rael, Barbra A Richardson, Jeanna M Piper, Linda-Gail Bekker, Suwat Chariyalertsak, Anupong Chitwarakorn, Pedro Gonzales, Timothy H Holtz, Albert Liu, Kenneth H Mayer, Carmen D Zorrilla, Javier R Lama, Ian McGowan, Ross D Cranston
Oral pre-exposure prophylaxis (PrEP) can prevent HIV transmission. Yet, some may prefer not to take systemic daily medication. MTN-017 was a 3-period, phase 2 safety and acceptability study of microbicide gel applied rectally either daily or before and after receptive anal intercourse (RAI), compared to daily oral tablet. At baseline, cisgender men and transgender women who reported RAI (N = 187) rated the daily oral regimen higher in overall liking, ease of use, and likelihood of future use than the gel regimens...
November 8, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29112632/prediction-of-60-day-case-fatality-in-critically-ill-patients-receiving-renal-replacement-therapy-external-validation-of-a-prediction-model
#5
Gloria Maria Custodio de Carvalho, Tacyano Tavares Leite, Alexandre Braga Libório
BACKGROUND: A recent prognostic model, predicting 60-day case fatality in critically-ill patients requiring RRT has been developed (Acute Renal Failure Trial Network - ATN study). Because many prognostic models are suggested in literature, but just a few have found its way into clinical practice, we aimed to externally validate this prediction model in an independent cohort. METHODS: 1,053 critically-ill patients requiring RRT from the MIMIC-III database were analyzed...
November 6, 2017: Shock
https://www.readbyqxmd.com/read/29062556/neurology-research-in-saudi-arabia-urgent-call-for-action
#6
Hussein Algahtani, Bader Shirah, Faisal Boker, Albaraa Algamdi, Abdulah Alkahtani
OBJECTIVES: Research activities in Saudi Arabia are promoted at the governmental and institutional levels. However, the output and quality of research conducted in the field of neurology has not yet been measured quantitatively. This study therefore aimed to analyse neurology-related publications from Saudi Arabia. METHODS: This study was conducted in January 2016. A systematic search using the PubMed(®) search engine (National Library of Medicine, Bethesda, Maryland, USA) was conducted to identify all neurology-related articles published from Saudi Arabia between January 1996 and December 2015...
August 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29057209/obesity-anthropometric-indicators-associated-with-cardiometabolic-risk-in-portuguese-children-and-adolescents
#7
Anelise Reis Gaya, Caroline Brand, Arieli Fernandes Dias, Adroaldo Cezar Araujo Gaya, Vanilson Batista Lemes, Jorge Mota
The purpose of this study was to determine the association between cardiometabolic risk with body mass index and skinfold independently or in combination in youth. This cross-sectional study comprised a convenience sample of 450 children and adolescents (255 girls), aged 10 to 18 years old. Indicators of body composition were measured, and hemodynamic assessment completed. The association between body mass index and/or sum of skinfolds and cardiometabolic risk (z score of the sum of triglycerides/high density lipoprotein cholesterol, waist circumference, and mean blood pressure), was calculated using Generalized Linear Models Regression...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29055177/pesticide-management-approach-towards-protecting-the-safety-and-health-of-farmers-in-southeast-asia
#8
REVIEW
Norsyazwani Mohammad, Emilia Zainal Abidin, Vivien How, Sarva Mangala Praveena, Zailina Hashim
BACKGROUND: It is estimated that pesticide production and use have increased continuously in the countries of Southeast Asia in recent years. Within the context of protecting the safety and health of workers in the agricultural sector, there is an existing gap in the implementation of the pesticide management framework because safety and health effects arising from occupational exposures continue to be reported. OBJECTIVE: This study aims to provide narrative similarities, differences and weaknesses of the existing pesticide management system in Southeast Asian countries (Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand and Vietnam) within the context of occupational safety and health...
October 21, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/29054307/early-and-late-surgical-outcomes-of-acute-type-a-aortic-dissection-in-octogenarians
#9
Koji Kawahito, Naoyuki Kimura, Atsushi Yamaguchi, Kei Aizawa, Yoshio Misawa, Hideo Adachi
BACKGROUND: Although surgical outcomes of acute type A aortic dissection (ATAAD) have improved, it is still a high-risk procedure for octogenarians. This study analyzed early and late outcomes of surgical repair of ATAAD among octogenarians. METHODS: From 1990 through 2016, 1,260 consecutive patients with ATAAD were emergently admitted to Jichi Medical University Hospitals. Of them, 1,026 patients who underwent emergency surgery for ATAAD within 48 hours of symptom onset were included in this retrospective study...
October 17, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29052450/measuring-the-implementation-of-youth-empowerment-solutions
#10
Susan Morrel-Samuels, Laney A Rupp, Andria B Eisman, Alison L Miller, Sarah A Stoddard, Susan P Franzen, Peter Hutchison, Marc A Zimmerman
Scholars have increasingly emphasized the importance of using evidence-based programs to promote health and prevent disease. While theoretically and empirically based programs may be effective in carefully controlled conditions, many fail to achieve desired outcomes when implemented in real-world settings. Ensuring high-quality implementation of health promotion programs is critically important as variation in implementation is closely associated with program effectiveness. The purpose of this article is to present methods used to document and assess the implementation of the Youth Empowerment Solutions (YES) program...
October 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/29050889/nine-point-plan-to-improve-care-of-the-injured-patient-a-case-study-from-kenya
#11
Abdulgafoor M Bachani, Isaac Botchey, Fatima Paruk, Daniel Wako, Hassan Saidi, Bethuel Aliwa, Simon Kibias, Adnan A Hyder
BACKGROUND: Injury rates in low- and middle-income countries are among the greatest in the world, with >90% of unintentional injury occurring in low- or middle-income countries. The risk of death from injuries is 6 times more in low- and middle-income countries than in high-income countries. This increased rate of injury is partly due to the lack of availability and access to timely and appropriate medical care for injured individuals. Kenya, like most low- and middle-income countries, has seen a 5-fold increase in injury fatalities throughout the past 4 decades, in large part related to the absence of a coordinated, integrated system of trauma care...
October 16, 2017: Surgery
https://www.readbyqxmd.com/read/29050739/-evaluation-about-patient-s-knowledge-on-their-direct-oral-anticoagulants-treatment
#12
V Pouyet, P Abassade, R Cador
AIM OF THE STUDY: Patient's knowledge about their treatment is poor, generally speaking. New oral anticoagulants are easier to use compared to antivitamin K, and they are going to increase. This simplification can underestimate their high potential risk. We have assessed patient's knowledge about their direct oral anticoagulants. METHODS: It was a quantitative, observational, multicentric, prospective study, on 50 patients on Direct Oral Anticoagulants. They have been included from November 2015 to February 2017, in Île-de-France...
November 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29050436/sound-analysis-to-model-weight-of-broiler-chickens
#13
Ilaria Fontana, Emanuela Tullo, Lenn Carpentier, Dries Berckmans, Andy Butterworth, Erik Vranken, Tomas Norton, Daniel Berckmans, Marcella Guarino
The pattern of body weight gain during the commercial growing of broiler chickens is important to understand growth and feed conversion ratio of each flock.The application of sound analysis techniques has been widely studied to measure and analyze the amplitude and frequency of animal sounds. Previous studies have shown a significant correlation (P ≤ 0.001) between the frequency of vocalization and the age and weight of broilers. Therefore, the aim of this study was to identify and validate a model that describes the growth rate of broiler chickens based on the peak frequency of their vocalizations and to explore the possibility to develop a tool capable of automatically detecting the growth of the chickens based on the frequency of their vocalizations during the production cycle...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29046622/essure%C3%A2-present-controversies-and-5%C3%A2-years-learned-lessons-a-retrospective-study-with-short-and-long-term-follow-up
#14
Sara Câmara, Filipa de Castro Coelho, Cláudia Freitas, Lilia Remesso
BACKGROUND: The risk-benefit of contraception with Essure® is being readdressed due to an increase of reports of adverse effects with this device. Our aim was to proceed to an internal quality evaluation and to identify opportunities for protocol improvement. We proceeded to a one-center, retrospective consecutive case series of women admitted for Essure® placement, from 1 January 2012 until 31 December 2016 (5 years). RESULTS: In a total of 274 women, technical difficulties were mainly unilateral, with no acute or short-term severe complications...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29045329/hybrid-deep-learning-on-single-wide-field-optical-coherence-tomography-scans-accurately-classifies-glaucoma-suspects
#15
Hassan Muhammad, Thomas J Fuchs, Nicole De Cuir, Carlos G De Moraes, Dana M Blumberg, Jeffrey M Liebmann, Robert Ritch, Donald C Hood
PURPOSE: Existing summary statistics based upon optical coherence tomographic (OCT) scans and/or visual fields (VFs) are suboptimal for distinguishing between healthy and glaucomatous eyes in the clinic. This study evaluates the extent to which a hybrid deep learning method (HDLM), combined with a single wide-field OCT protocol, can distinguish eyes previously classified as either healthy suspects or mild glaucoma. METHODS: In total, 102 eyes from 102 patients, with or suspected open-angle glaucoma, had previously been classified by 2 glaucoma experts as either glaucomatous (57 eyes) or healthy/suspects (45 eyes)...
October 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29044493/combining-echo-and-natriuretic-peptides-to-guide-heart-failure-care-in-the-outpatient-setting-a-position-paper
#16
REVIEW
Frank Lloyd Dini, Erberto Carluccio, Fabrizio Montecucco, Gian Marco Rosa, Paolo Fontanive
BACKGROUND: Chronic heart failure (HF) is a relevant and growing public health problem. Although the prognosis has recently improved, it remains a lethal disease, with a mortality that equals or exceeds that of many malignancies. Furthermore, chronic HF is costly, representing a large and growing drain on healthcare resources. METHODS: This narrative review is based on the material searched for and obtained via PubMed up to May 2017. The search terms we used were: "heart failure, echocardiography, natriuretic peptides" in combination with "treatment, biomarkers, guidelines"...
October 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29037018/role-of-fractionated-radiotherapy-in-patients-with-hemangioma-of-the-cavernous-sinus
#17
Sunmin Park, Sang Min Yoon, Sumin Lee, Jin-Hong Park, Si Yeol Song, Sang-Wook Lee, Seung Do Ahn, Jong Hoon Kim, Eun Kyung Choi
PURPOSE: We performed this retrospective study to investigate the outcomes of patients with hemangioma of the cavernous sinus after fractionated radiotherapy. MATERIALS AND METHODS: We analyzed 10 patients with hemangioma of the cavernous sinus who were treated with conventional radiotherapy between January 2000 and December 2016. The median patient age was 54 years (range, 31-65 years), and 8 patients (80.0%) were female. The mean hemangioma volume was 34.1 cm(3) (range, 6...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29033989/effectiveness-of-back-massage-on-sleep-pattern-among-patients-with-congestive-cardiac-failure
#18
Amol Sable, Thangaraj Sivabalan, Akshaya Narayan Shetti
BACKGROUND: Sleep plays an important role in congestive cardiac failure (CCF). Back massage reduces anxiety, discomfort, and physical suffering in CCF patients. Study objective is to assess sleep pattern in CCF patients before and after back massage. MATERIALS AND METHODS: A quasi-experimental study was conducted in Pravara Rural hospital, Loni, India over 4 months in 2016. Thirty CCF patients were included in the study with purposive sampling. Nurse investigator performed 20-min back massage thrice daily, 5 min for each step from the day of admission till discharge...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29032923/is-it-necessary-to-dissect-the-posterior-lymph-nodes-along-the-splenic-vessels-during-total-gastrectomy-with-d2-lymphadenectomy-for-advanced-gastric-cancer
#19
Jian-Xian Lin, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin
BACKGROUND: D2 lymphadenectomy including No.10 lymph nodes (LNs) is the standard procedure for treating advanced gastric cancer (AGC) via total gastrectomy. However, there was no research focusing on the posterior LN dissection along the splenic vessels (No.10p LNs). This study is performed to assess the effect of dissecting No.10p LNs. METHODS: We analyzed 404 consecutive gastric cancer patients who underwent laparoscopic total gastrectomy (LTG) with D2 lymphadenectomy...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29031803/the-burden-and-correlates-of-hypertension-among-chinese-rural-population-in-han-uygur-and-kazak-%C3%A2-a%C3%A2-cross-sectional-study
#20
Yong-Tao Wang, Dilare Adi, Zi-Xiang Yu, Yi-Tong Ma, Yi-Ning Yang, Xiao-Mei Li, Xiang Ma, Fen Liu, Bang-Dang Chen
The present study was conducted to investigate the prevalence, awareness, treatment, control, and associated risk factors of hypertension among rural population in Xinjiang Province in Northwest China. The Cardiovascular Risk Survey study was conducted on a representative sample of the Northwest China adult population. A four-stage stratified cluster random sampling scheme was adopted to recruit representative samples. The data were collected by trained staff. Multivariable logistic regression models were used to identify the associated risk factors...
November 2017: Journal of the American Society of Hypertension: JASH
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