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https://www.readbyqxmd.com/read/28323442/an-investigation-of-human-body-model-morphing-for-the-assessment-of-abdomen-responses-to-impact-against-a-population-of-test-subjects
#1
Philippe Beillas, Fabien Berthet
OBJECTIVE: Human Body Models have the potential to better describe the human anatomy and variability than dummies. However, datasets available to verify the human response to impact are typically limited in numbers, and they are not size or gender specific. The objective of the study was to investigate the use of model morphing methodologies within that context. METHODS: In the current study, a simple human model scaling methodology was developed to morph two detailed human models (Global Human Body Model Consortium models 50(th) male, M50 and 5(th) female F05) to the dimensions of Post Mortem Human Surrogates (PMHS) used in published literature...
March 21, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28321689/doing-the-right-thing-a-qualitative-investigation-of-retractions-due-to-unintentional-error
#2
Mohammad Hosseini, Medard Hilhorst, Inez de Beaufort, Daniele Fanelli
Retractions solicited by authors following the discovery of an unintentional error-what we henceforth call a "self-retraction"-are a new phenomenon of growing importance, about which very little is known. Here we present results of a small qualitative study aimed at gaining preliminary insights about circumstances, motivations and beliefs that accompanied the experience of a self-retraction. We identified retraction notes that unambiguously reported an honest error and that had been published between the years 2010 and 2015...
March 20, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28319767/potential-for-thermochemical-conversion-of-biomass-residues-from-the-integrated-sugar-ethanol-process-fate-of-ash-and-ash-forming-elements
#3
Meheretu Jaleta Dirbeba, Anders Brink, Nikolai DeMartini, Maria Zevenhoven, Mikko Hupa
In this work, potential for thermochemical conversion of biomass residues from an integrated sugar-ethanol process and the fate of ash and ash-forming elements in the process are presented. Ash, ash-forming elements, and energy flows in the process were determined using mass balances and analyses of eight different biomass samples for ash contents, elemental compositions, and heating values. The results show that the ash content increases from the sugarcane to the final residue, vinasse. The cane straw, which is left in the field, contains one-third of the energy and 25% of the K and Cl while the vinasse contains 2% of the energy and 40% of the K and Cl in the cane...
March 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28317374/flexible-and-thermostable-graphene-sic-nanowires-foam-composites-with-tunable-electromagnetic-wave-absorption-properties
#4
Meikang Han, Xiaowei Yin, Zexin Hou, Changqing Song, Xinliang Li, Litong Zhang, Laifei Cheng
Three-dimensional (3D) flexible foams consisting of reduced graphene oxides (rGO) and in-situ grown SiC nanowires (NWs) were prepared using freeze-drying and carbothermal reduction process. By means of incorporating SiC nanowires into rGO foams, both the thermostability and electromagnetic absorption of the composites were improved. It was demonstrated that rGO/SiC NWs foams were thermostable beyond ~630 °C (90% weight retention in air atmosphere). As expected, rGO/SiC NWs foams in the poly (dimethylsiloxane) matrix achieved effective absorption in the entire X-band (8...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28295667/a-novel-potassium-ion-based-dual-ion-battery
#5
Bifa Ji, Fan Zhang, Xiaohe Song, Yongbing Tang
In this work, combining both advantages of potassium-ion batteries and dual-ion batteries, a novel potassium-ion-based dual-ion battery (named as K-DIB) system is developed based on a potassium-ion electrolyte, using metal foil (Sn, Pb, K, or Na) as anode and expanded graphite as cathode. When using Sn foil as the anode, the K-DIB presents a high reversible capacity of 66 mAh g(-1) at a current density of 50 mA g(-1) over the voltage window of 3.0-5.0 V, and exhibits excellent long-term cycling performance with 93% capacity retention for 300 cycles...
March 15, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28293884/ultrasensitive-firefly-luminescent-intermediate-based-protein-protein-interaction-assay-flimpia-based-on-the-functional-complementation-of-mutant-firefly-luciferases
#6
Yuki Ohmuro-Matsuyama, Hiroshi Ueda
We recently developed a protein-protein interaction assay, FlimPIA (Firefly luminescent intermediate-based Protein-protein Interaction Assay) based on the catalytic mechanism of firefly luciferase (Fluc) that can be divided into two half-reactions: the adenylation step and the oxidative luminescent steps. We engineered two mutant Fluc enzymes named "Donor" and "Acceptor" where the oxidative luminescent activity of the Donor is almost eliminated and the adenylation activity of the Acceptor is suppressed. When the Donor and the Acceptor are each fused to one of two interacting partners, and put together to interact, the Donor and the Acceptor come sufficiently close such that the Acceptor can react with the luciferyl-adenylate intermediate (LH2-AMP) produced by the Donor, and thus emit luminescence...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28291866/long-term-safety-and-efficacy-of-achieving-very-low-levels-of-low-density-lipoprotein-cholesterol-a-prespecified-analysis-of-the-improve-it-trial
#7
Robert P Giugliano, Stephen D Wiviott, Michael A Blazing, Gaetano M De Ferrari, Jeong-Gun Park, Sabina A Murphy, Jennifer A White, Andrew M Tershakovec, Christopher P Cannon, Eugene Braunwald
Importance: In the Improved Reduction of Outcomes: Vytorin Efficacy International Trial, intensive low-density lipoprotein cholesterol (LDL-C)-reducing therapy with ezetimibe/simvastatin compared with simvastatin alone was associated with a significant reduction in cardiovascular events in 18 144 patients after acute coronary syndrome. The safety of very low LDL-C levels over the long-term is unknown. Objective: To assess the safety and clinical efficacy of achieving a very low (<30 mg/dL) level of LDL-C at 1 month using data from the Improved Reduction of Outcomes: Vytorin Efficacy International Trial...
March 14, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28285283/factors-affecting-subsequent-full-text-publication-of-papers-presented-at-the-annual-conference-of-the-indian-academy-of-pediatrics
#8
Sumaira Khalil, Devendra Mishra, Ruchi Mishra, Shalu Gupta
OBJECTIVE: To study the factors associated with the subsequent (over next 9 years) full-text publication of papers presented at the 44th National Conference of Indian Academy of Pediatrics (PEDICON), 2007. METHODS: All papers presented at PEDICON 2007 were searched for subsequent full-text publication over the next 9 years in English-language journals by an internet-based search. The published papers were compared with the conference-abstracts. Results: 74 (16%) of the 450 abstracts presented were subsequently published; 61 (82...
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28284377/treatment-of-renal-fibrosis-turning-challenges-into-opportunities
#9
REVIEW
Barbara M Klinkhammer, Roel Goldschmeding, Jürgen Floege, Peter Boor
Current treatment modalities are not effective in halting the progression of most CKD. Renal fibrosis is a pathological process common to all CKD and thereby represents an excellent treatment target. A large number of molecular pathways involved in renal fibrosis were identified in preclinical studies, some of them being similar among different organs and some with available drugs in various phases of clinical testing. Yet only few clinical trials with antifibrotic drugs are being conducted in CKD patients...
March 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/28275594/enabling-continuous-quality-improvement-in-practice-the-role-and-contribution-of-facilitation
#10
Gillian Harvey, Elizabeth Lynch
Facilitating the implementation of continuous quality improvement (CQI) is a complex undertaking. Numerous contextual factors at a local, organizational, and health system level can influence the trajectory and ultimate success of an improvement program. Some of these contextual factors are amenable to modification, others less so. As part of planning and implementing healthcare improvement, it is important to assess and build an understanding of contextual factors that might present barriers to or enablers of implementation...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28268965/path-based-connectivity-for-clustering-genome-sequences
#11
Oznur Sengel, Olcay Kursun
Clustering is an unsupervised data mining tool and in bioinformatics, clustering genome sequences is used to group related biological sequences when there is no additional supervision. Sequence clusters are often related with gene/protein families, which can shed some light onto determining tertiary structures. To extract such hidden and valuable structures in a data set of genome sequences can benefit from better clustering methods such as the recently popular Spectral Clustering. In this study, we apply spectral clustering and its improved variations to sequence clustering task in our efforts to develop a novel approach for improving it...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28265525/a-study-of-emotional-intelligence-among-postgraduate-medical-students-in-delhi
#12
Rajkrishna Ravikumar, O P Rajoura, Rahul Sharma, Manjeet S Bhatia
CONTEXT: The importance of emotional intelligence (EI) in the successful practice of medicine has been well established. However, efforts to study the same in India, especially in doctors and medical students, are lacking. This study has measured the emotional intelligence of postgraduate medical students in Delhi and aimed to identify some of the factors affecting it. METHODS: A cross-sectional analytical study, using the Schutte's Self-Report Emotional Intelligence Test, to measure the EI of 200 postgraduate medical students of two medical colleges in Delhi...
January 22, 2017: Curēus
https://www.readbyqxmd.com/read/28255135/patients-blood-pressure-control-and-doctors-adherence-to-hypertension-clinical-practice-guideline-in-managing-patients-at-health-clinics-in-kuala-muda-district-kedah
#13
S H Teoh, A R Razlina, D Norwati, M Y Siti Suhaila
BACKGROUND: blood pressure (bP) control among Malaysian is poor and doctor's adherence to clinical practice guideline (cPG) has been a well-known factor that may improve it. this study was designed to evaluate patients' bP control, doctors' adherence to the latest hypertension cPG and their association. Factors associated with bP control and cPG adherence was also examined. METHODS: A cross-sectional study was conducted in Kuala Muda district's health clinics. 331 medical records were selected using stratified random sampling and standard proforma was used for data collection...
February 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28246484/how-to-improve-patient-satisfaction-during-midazolam-sedation-for-gastrointestinal-endoscopy
#14
Eun Hyo Jin, Kyoung Sup Hong, Young Lee, Ji Yeon Seo, Ji Min Choi, Jaeyoung Chun, Sang Gyun Kim, Joo Sung Kim, Hyun Chae Jung
AIM: To determine the procedure-related factors that affect sedation satisfaction and to make a suggestion to improve it. METHODS: We prospectively enrolled a total of 456 patients who underwent outpatient endoscopy procedures with midazolam sedation between March 2014 and August 2014. All patients completed both pre- and post-endoscopy questionnaires about sedation expectations and satisfaction. RESULTS: The study cohort included 167 (36...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28242710/mechanism-and-bottlenecks-in-strand-photodissociation-of-split-green-fluorescent-proteins-gfps
#15
Chi-Yun Lin, Johan Both, Keunbong Do, Steven G Boxer
Split GFPs have been widely applied for monitoring protein-protein interactions by expressing GFPs as two or more constituent parts linked to separate proteins that only fluoresce on complementing with one another. Although this complementation is typically irreversible, it has been shown previously that light accelerates dissociation of a noncovalently attached β-strand from a circularly permuted split GFP, allowing the interaction to be reversible. Reversible complementation is desirable, but photodissociation has too low of an efficiency (quantum yield <1%) to be useful as an optogenetic tool...
February 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28237348/early-postpartum-administration-of-equine-chorionic-gonadotropin-to-dairy-cows-calved-during-the-hot-season-effects-on-fertility-after-first-artificial-insemination
#16
R Patron-Collantes, I Lopez-Helguera, J L Pesantez-Pacheco, F Sebastian, M Fernández, O Fargas, S Astiz
Heat stress reduces fertility of high-producing dairy cows, and early administration of equine chorionic gonadotropin (eCG) may improve it. Here, 401 heat-stressed, high-producing dairy cows on a single commercial farm were given eCG (500 UI, n = 214) or saline (n = 187) on days 11-17 after calving, and the effects on fertility after the first artificial insemination (AI) were assessed. On post-partum day 96.34 ± 9.88, all cows were inseminated after a "double short Cosynch" synchronization protocol...
April 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28227172/path-based-connectivity-for-clustering-genome-sequences
#17
Oznur Sengel, Olcay Kursun, Oznur Sengel, Olcay Kursun, Olcay Kursun, Oznur Sengel
Clustering is an unsupervised data mining tool and in bioinformatics, clustering genome sequences is used to group related biological sequences when there is no additional supervision. Sequence clusters are often related with gene/protein families, which can shed some light onto determining tertiary structures. To extract such hidden and valuable structures in a data set of genome sequences can benefit from better clustering methods such as the recently popular Spectral Clustering. In this study, we apply spectral clustering and its improved variations to sequence clustering task in our efforts to develop a novel approach for improving it...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28213887/rituals-improve-children-s-ability-to-delay-gratification
#18
Veronika Rybanska, Ryan McKay, Jonathan Jong, Harvey Whitehouse
To be accepted into social groups, individuals must internalize and reproduce appropriate group conventions, such as rituals. The copying of such rigid and socially stipulated behavioral sequences places heavy demands on executive function. Given previous research showing that challenging executive functioning improves it, it was hypothesized that engagement in ritualistic behaviors improves children's executive functioning, in turn improving their ability to delay gratification. A 3-month circle time games intervention with 210 schoolchildren (Mage  = 7...
February 18, 2017: Child Development
https://www.readbyqxmd.com/read/28212173/prediction-of-conversion-to-psychosis-in-individuals-with-an-at-risk-mental-state-a-brief-update-on-recent-developments
#19
Anita Riecher-Rössler, Erich Studerus
PURPOSE OF REVIEW: So far, only little more than one-third of individuals classified as being at-risk for psychosis have been shown to actually convert to frank psychosis during follow-up. There have therefore been enormous efforts to improve the accuracy of predicting this transition. We reviewed the most recent studies in the field with the aim to clarify whether accuracy of prediction has been improved by the different research endeavors and what could be done to further improve it, and/or what alternative goals research should pursue...
February 15, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28209583/combining-diffusion-tensor-metrics-and-dsc-perfusion-imaging-can-it-improve-the-diagnostic-accuracy-in-differentiating-tumefactive-demyelination-from-high-grade-glioma
#20
S B Hiremath, A Muraleedharan, S Kumar, C Nagesh, C Kesavadas, M Abraham, T R Kapilamoorthy, B Thomas
BACKGROUND AND PURPOSE: Tumefactive demyelinating lesions with atypical features can mimic high-grade gliomas on conventional imaging sequences. The aim of this study was to assess the role of conventional imaging, DTI metrics (p:q tensor decomposition), and DSC perfusion in differentiating tumefactive demyelinating lesions and high-grade gliomas. MATERIALS AND METHODS: Fourteen patients with tumefactive demyelinating lesions and 21 patients with high-grade gliomas underwent brain MR imaging with conventional, DTI, and DSC perfusion imaging...
February 16, 2017: AJNR. American Journal of Neuroradiology
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