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https://www.readbyqxmd.com/read/28448925/geostatistics-as-a-tool-to-improve-the-natural-background-level-definition-an-application-in-groundwater
#1
Nico Dalla Libera, Paolo Fabbri, Leonardo Mason, Leonardo Piccinini, Marco Pola
The Natural Background Level (NBL), suggested by UE BRIDGE project, is suited for spatially distributed datasets providing a regional value that could be higher than the Threshold Value (TV) set by every country. In hydro-geochemically dis-homogeneous areas, the use of a unique regional NBL, higher than TV, could arise problems to distinguish between natural occurrences and anthropogenic contaminant sources. Hence, the goal of this study is to improve the NBL definition employing a geostatistical approach, which reconstructs the contaminant spatial structure accounting geochemical and hydrogeological relationships...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441906/setting-priorities-for-eu-healthcare-workforce-it-skills-competence-improvement
#2
Sisi Li, Panagiotis D Bamidis, Stathis Th Konstantinidis, Vicente Traver, Josip Car, Nabil Zary
A major challenge for healthcare quality improvement is the lack of IT skills and knowledge of healthcare workforce, as well as their ambivalent attitudes toward IT. This article identifies and prioritizes actions needed to improve the IT skills of healthcare workforce across the EU. A total of 46 experts, representing different fields of expertise in healthcare and geolocations, systematically listed and scored actions that would improve IT skills among healthcare workforce. The Child Health and Nutrition Research Initiative methodology was used for research priority-setting...
April 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#3
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28437531/applicability-of-the-improve-it-trial-to-current-patients-with-acute-coronary-syndrome-an-ncdr-research-to-practice-project
#4
Thomas M Maddox, Fengming Tang, John R Downs, Frederick A Masoudi, Salim S Virani, Stacie L Daugherty, John S Rumsfeld
No abstract text is available yet for this article.
April 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28409215/high-and-pointed-type-of-femoral-localized-reaction-frequently-extends-to-complete-and-incomplete-atypical-femoral-fracture-in-patients-with-autoimmune-diseases-on-long-term-glucocorticoids-and-bisphosphonates
#5
H Sato, N Kondo, T Nakatsue, Y Wada, J Fujisawa, J J Kazama, T Kuroda, Y Suzuki, M Nakano, N Endo, I Narita
Once a localized reaction (beaking) was detected, discontinuation of bisphosphonates (BPs) and switching to vitamin D supplementation or teriparatide therapy effectively improved its shape. When the localized reaction was high, of the pointed type, and/or accompanied by prodromal pain, the risks of complete and incomplete atypical femoral fracture increased and consideration of prophylactic fixation for such patients was required. INTRODUCTION: Femoral localized reaction (localized periosteal thickening of the lateral cortex, beaking) is reported to precede atypical femoral fractures (AFFs) and to develop in 8-10% of patients with autoimmune diseases taking BPs and glucocorticoids...
April 13, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28408116/-prevalence-of-oral-anticoagulation-and-quality-of-its-management-in-primary-healthcare-a-study-by-the-health-sentinel-network-of-the-region-of-valencia-spain
#6
Ana Boned-Ombuena, Jordi Pérez-Panadés, Aurora López-Maside, Maite Miralles-Espí, Sandra Guardiola Vilarroig, Desamparados Adam Ruiz, Oscar Zurriaga
OBJECTIVE: To estimate the prevalence of patients with oral anticoagulant therapy (OAT) in the Region of Valencia and to evaluate the quality of management of OAT with vitaminK antagonists (VKA) carried out in primary healthcare. DESIGN: Observational cross-sectional study conducted through the Health Sentinel Network of the Region of Valencia, which includes a survey and the retrospective analysis of OAT monitoring. SETTING: Primary healthcare, Region of Valencia, Spain...
April 10, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28398074/what-do-we-know-about-the-health-of-spanish-roma-people-and-what-has-been-done-to-improve-it-a-scoping-review
#7
Ana Fernández-Feito, Raúl Pesquera-Cabezas, Carmen González-Cobo, M Dolores Prieto-Salceda
OBJECTIVES: This study aims to review the published literature on the health of the Roma population in Spain, particularly that which describes health interventions and outcomes. DESIGN: A scoping review of published articles/reports on Roma population health was carried out in Spain for publications between 2002 and 2014. Articles in Spanish or English were identified from Pubmed, Scopus, Science Direct, Web of Science, Scielo, IBECS, MEDES, Dialnet, Index Foundation, a database of theses and Google Scholar...
April 11, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28367530/choroidal-neovascularization-following-photorefractive-keratectomy
#8
Hamidreza Torabi, Seyed-Hashem Daryabari
PURPOSE: To describe a case of choroidal neovascularization (CNV) following photorefractive keratectomy (PRK) to correct myopia. METHODS: We performed PRK in both eyes of a 20-year-old girl to correct myopia. Refractive error was -4.75 -2.25 × 5 in the right eye and -5.00 -1.25 × 180 in the left eye. Metamorphopsia was noticed by the patient in the right eye one month after the surgical procedure. The patient was referred 3 months later when visual loss happened...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28350328/vitamin-d-decreases-serum-vegf-correlating-with-clinical-improvement-in-vitamin-d-deficient-women-with-pcos-a-randomized-placebo-controlled-trial
#9
Mohamad Irani, David B Seifer, Richard V Grazi, Sara Irani, Zev Rosenwaks, Reshef Tal
Vascular endothelial growth factor (VEGF) has been suggested to play a role in the pathophysiology of polycystic ovary syndrome (PCOS) and may contribute to increased risk of ovarian hyperstimulation syndrome (OHSS) in affected individuals. Vitamin D (VitD) supplementation improves multiple clinical parameters in VitD-deficient women with PCOS and decreases VEGF levels in several other pathologic conditions. Unveiling the basic mechanisms underlying the beneficial effects of vitamin D on PCOS may enhance our understanding of the pathophysiology of this syndrome...
March 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28349052/hybrid-methods-in-iron-sulfur-cluster-biogenesis
#10
REVIEW
Filippo Prischi, Annalisa Pastore
Hybrid methods, which combine and integrate several biochemical and biophysical techniques, have rapidly caught up in the last twenty years to provide a way to obtain a fuller description of proteins and molecular complexes with sizes and complexity otherwise not easily affordable. Here, we review the use of a robust hybrid methodology based on a mixture of NMR, SAXS, site directed mutagenesis and molecular docking which we have developed to determine the structure of weakly interacting molecular complexes...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28344680/adolescents-and-young-adults-na%C3%A3-ve-understandings-of-the-economic-crisis
#11
Anna Emilia Berti, Anna Maria Ajello, Carmela Aprea, Ilaria Castelli, Elisabetta Lombardi, Antonella Marchetti, Davide Massaro, Viviana Sappa, Annalisa Valle
Over the last decade, Financial Literacy (FL) and interventions aimed at improving it, that is Financial Education (FE), have been the focus of increased attention from economists, governments, and international organizations such as the world Bank and OECD, but much less by scholars in the fields of Learning and Instruction. We examined open-ended written answers on the causes of the economic crisis that started in 2007-2008, as given by 381 Italian secondary school and university students, and 268 Swiss Italian-speaking secondary school students...
March 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28323442/an-investigation-of-human-body-model-morphing-for-the-assessment-of-abdomen-responses-to-impact-against-a-population-of-test-subjects
#12
Philippe Beillas, Fabien Berthet
OBJECTIVE: Human Body Models have the potential to better describe the human anatomy and variability than dummies. However, datasets available to verify the human response to impact are typically limited in numbers, and they are not size or gender specific. The objective of the study was to investigate the use of model morphing methodologies within that context. METHODS: In the current study, a simple human model scaling methodology was developed to morph two detailed human models (Global Human Body Model Consortium models 50(th) male, M50 and 5(th) female F05) to the dimensions of Post Mortem Human Surrogates (PMHS) used in published literature...
March 21, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28321689/doing-the-right-thing-a-qualitative-investigation-of-retractions-due-to-unintentional-error
#13
Mohammad Hosseini, Medard Hilhorst, Inez de Beaufort, Daniele Fanelli
Retractions solicited by authors following the discovery of an unintentional error-what we henceforth call a "self-retraction"-are a new phenomenon of growing importance, about which very little is known. Here we present results of a small qualitative study aimed at gaining preliminary insights about circumstances, motivations and beliefs that accompanied the experience of a self-retraction. We identified retraction notes that unambiguously reported an honest error and that had been published between the years 2010 and 2015...
March 20, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28319767/potential-for-thermochemical-conversion-of-biomass-residues-from-the-integrated-sugar-ethanol-process-fate-of-ash-and-ash-forming-elements
#14
Meheretu Jaleta Dirbeba, Anders Brink, Nikolai DeMartini, Maria Zevenhoven, Mikko Hupa
In this work, potential for thermochemical conversion of biomass residues from an integrated sugar-ethanol process and the fate of ash and ash-forming elements in the process are presented. Ash, ash-forming elements, and energy flows in the process were determined using mass balances and analyses of eight different biomass samples for ash contents, elemental compositions, and heating values. The results show that the ash content increases from the sugarcane to the final residue, vinasse. The cane straw, which is left in the field, contains one-third of the energy and 25% of the K and Cl while the vinasse contains 2% of the energy and 40% of the K and Cl in the cane...
March 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28317374/flexible-and-thermostable-graphene-sic-nanowire-foam-composites-with-tunable-electromagnetic-wave-absorption-properties
#15
Meikang Han, Xiaowei Yin, Zexin Hou, Changqing Song, Xinliang Li, Litong Zhang, Laifei Cheng
Three-dimensional (3D) flexible foams consisting of reduced graphene oxides (rGO) and in situ grown SiC nanowires (NWs) were prepared using freeze-drying and carbothermal reduction processes. By means of incorporating SiC nanowires into rGO foams, both the thermostability and electromagnetic absorption of the composites were improved. It was demonstrated that rGO/SiC NW foams were thermostable beyond ∼630 °C (90% weight retention in air atmosphere). As expected, rGO/SiC NW foams in the poly(dimethylsiloxane) matrix achieved effective absorption in the entire X-band (8...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28295667/a-novel-potassium-ion-based-dual-ion-battery
#16
Bifa Ji, Fan Zhang, Xiaohe Song, Yongbing Tang
In this work, combining both advantages of potassium-ion batteries and dual-ion batteries, a novel potassium-ion-based dual-ion battery (named as K-DIB) system is developed based on a potassium-ion electrolyte, using metal foil (Sn, Pb, K, or Na) as anode and expanded graphite as cathode. When using Sn foil as the anode, the K-DIB presents a high reversible capacity of 66 mAh g(-1) at a current density of 50 mA g(-1) over the voltage window of 3.0-5.0 V, and exhibits excellent long-term cycling performance with 93% capacity retention for 300 cycles...
March 15, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28293884/ultrasensitive-firefly-luminescent-intermediate-based-protein-protein-interaction-assay-flimpia-based-on-the-functional-complementation-of-mutant-firefly-luciferases
#17
Yuki Ohmuro-Matsuyama, Hiroshi Ueda
We recently developed a protein-protein interaction assay, FlimPIA (Firefly luminescent intermediate-based Protein-protein Interaction Assay) based on the catalytic mechanism of firefly luciferase (Fluc) that can be divided into two half-reactions: the adenylation step and the oxidative luminescent steps. We engineered two mutant Fluc enzymes named "Donor" and "Acceptor" where the oxidative luminescent activity of the Donor is almost eliminated and the adenylation activity of the Acceptor is suppressed. When the Donor and the Acceptor are each fused to one of two interacting partners, and put together to interact, the Donor and the Acceptor come sufficiently close such that the Acceptor can react with the luciferyl-adenylate intermediate (LH2-AMP) produced by the Donor, and thus emit luminescence...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28291866/long-term-safety-and-efficacy-of-achieving-very-low-levels-of-low-density-lipoprotein-cholesterol-a-prespecified-analysis-of-the-improve-it-trial
#18
Robert P Giugliano, Stephen D Wiviott, Michael A Blazing, Gaetano M De Ferrari, Jeong-Gun Park, Sabina A Murphy, Jennifer A White, Andrew M Tershakovec, Christopher P Cannon, Eugene Braunwald
Importance: In the Improved Reduction of Outcomes: Vytorin Efficacy International Trial, intensive low-density lipoprotein cholesterol (LDL-C)-reducing therapy with ezetimibe/simvastatin compared with simvastatin alone was associated with a significant reduction in cardiovascular events in 18 144 patients after acute coronary syndrome. The safety of very low LDL-C levels over the long-term is unknown. Objective: To assess the safety and clinical efficacy of achieving a very low (<30 mg/dL) level of LDL-C at 1 month using data from the Improved Reduction of Outcomes: Vytorin Efficacy International Trial...
March 14, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28285283/factors-affecting-subsequent-full-text-publication-of-papers-presented-at-the-annual-conference-of-the-indian-academy-of-pediatrics
#19
Sumaira Khalil, Devendra Mishra, Ruchi Mishra, Shalu Gupta
OBJECTIVE: To study the factors associated with the subsequent (over next 9 years) full-text publication of papers presented at the 44th National Conference of Indian Academy of Pediatrics (PEDICON), 2007. METHODS: All papers presented at PEDICON 2007 were searched for subsequent full-text publication over the next 9 years in English-language journals by an internet-based search. The published papers were compared with the conference-abstracts. Results: 74 (16%) of the 450 abstracts presented were subsequently published; 61 (82...
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28284377/treatment-of-renal-fibrosis-turning-challenges-into-opportunities
#20
REVIEW
Barbara M Klinkhammer, Roel Goldschmeding, Jürgen Floege, Peter Boor
Current treatment modalities are not effective in halting the progression of most CKD. Renal fibrosis is a pathological process common to all CKD and thereby represents an excellent treatment target. A large number of molecular pathways involved in renal fibrosis were identified in preclinical studies, some of them being similar among different organs and some with available drugs in various phases of clinical testing. Yet only few clinical trials with antifibrotic drugs are being conducted in CKD patients...
March 2017: Advances in Chronic Kidney Disease
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