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https://www.readbyqxmd.com/read/28923989/competing-risks-of-cardiovascular-versus-noncardiovascular-death-during-long-term-follow-up-after-acute-coronary-syndromes
#1
Alexander C Fanaroff, Matthew T Roe, Robert M Clare, Yuliya Lokhnygina, Ann Marie Navar, Robert P Giugliano, Stephen D Wiviott, Andrew M Tershakovec, Eugene Braunwald, Michael A Blazing
BACKGROUND: Understanding the relative risk of cardiovascular versus noncardiovascular death is important for designing clinical trials. These risks may differ depending on patient age, sex, and type of acute coronary syndrome (ACS). METHODS AND RESULTS: IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) was a randomized controlled trial of simvastatin plus either ezetimibe or placebo following stabilized ACS. Cause of death was adjudicated by an independent committee...
September 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28922021/pharmacokinetic-drug-evaluation-of-ezetimibe-simvastatin-for-the-treatment-of-hypercholesterolemia
#2
Marilisa Bove, Federica Fogacci, Arrigo Cicero
-Introduction: Cholesterol lowering treatment is mainly based on statins eventually associated to adjunctive drugs of different class such as ezetimibe. In the present review, we analysed the pharmacokinetics, efficacy and safety of ezetimibe+simvastatin drug association. -Areas covered: The bio-equivalence of ezetimibe and simvastatin when co-administrated in separate tablets or combined in a single pill is well documented. Ezetimibe is absorbed in small intestine, reaching peak plasma concentrations in 4-12 hours, with a plasma half-life of 22 hours...
September 18, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28916559/omics-analyses-of-trichoderma-reesei-cbs999-97-and-qm6a-indicate-a-relevance-of-female-fertility-for-cazyme-and-transporter-levels
#3
Doris Tisch, Kyle R Pomraning, James R Collett, Michael Freitag, Scott E Baker, Chia-Ling Chen, Paul Wei-Che Hsu, Yu Chien Chuang, Andre Schuster, Christoph Dattenböck, Eva Stappler, Michael Sulyok, Stefan Böhmdorfer, Josua Oberlerchner, Ting-Fang Wang, Monika Schmoll
The filamentous fungus Trichoderma reesei is predominantly found in the tropics, but also in more temperate regions, such as Europe and is widely known as producer of high amounts of plant cell wall degrading enzymes. We sequenced the genome of the sexually competent isolate CBS999.97, which is phenotypically different from female sterile QM6a, but can cross sexually with QM6a. Transcriptome data for growth on cellulose showed that entire CAZyme families are consistently differentially regulated between these strains...
September 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28915458/physical-water-scarcity-metrics-for-monitoring-progress-towards-sdg-target-6-4-an-evaluation-of-indicator-6-4-2-level-of-water-stress
#4
REVIEW
D Vanham, A Y Hoekstra, Y Wada, F Bouraoui, A de Roo, M M Mekonnen, W J van de Bund, O Batelaan, P Pavelic, W G M Bastiaanssen, M Kummu, J Rockström, J Liu, B Bisselink, P Ronco, A Pistocchi, G Bidoglio
Target 6.4 of the recently adopted Sustainable Development Goals (SDGs) deals with the reduction of water scarcity. To monitor progress towards this target, two indicators are used: Indicator 6.4.1 measuring water use efficiency and 6.4.2 measuring the level of water stress (WS). This paper aims to identify whether the currently proposed indicator 6.4.2 considers the different elements that need to be accounted for in a WS indicator. WS indicators compare water use with water availability. We identify seven essential elements: 1) both gross and net water abstraction (or withdrawal) provide important information to understand WS; 2) WS indicators need to incorporate environmental flow requirements (EFR); 3) temporal and 4) spatial disaggregation is required in a WS assessment; 5) both renewable surface water and groundwater resources, including their interaction, need to be accounted for as renewable water availability; 6) alternative available water resources need to be accounted for as well, like fossil groundwater and desalinated water; 7) WS indicators need to account for water storage in reservoirs, water recycling and managed aquifer recharge...
September 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28890119/do-we-perform-surgical-programming-well-how-can-we-improve-it
#5
J Albareda, D Clavel, C Mahulea, N Blanco, L Ezquerra, J Gómez, J M Silva
The objective is to establish the duration of our interventions, intermediate times and surgical performance. This will create a virtual waiting list to apply a mathematical programme that performs programming with maximum performance. MATERIAL AND METHODS: Retrospective review of 49 surgical sessions obtaining the delay in start time, intermediate time and surgical performance. Retrospective review of 4,045 interventions performed in the last 3 years to obtain the average duration of each type of surgery...
September 7, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28875059/comparison-of-three-internship-training-sites-for-an-undergraduate-health-information-management-program-in-saudi-arabia
#6
Sulaiman Bah, Turki Alanzi
OBJECTIVES: While internship training is well established for medical records and for healthcare quality improvement, it is not quite so for training related to IT/health informatics. A comparison was made on the hospital-based IT/health informatics internship training received by students completing their training at the Imam AbdulRahman Bin Faisal University (IAU) in the Eastern province of Saudi Arabia. METHODS: The three hospitals studied all have the Joint Commission International accreditation and advanced Electronic Health Record (EHR) systems...
July 2017: Healthcare Informatics Research
https://www.readbyqxmd.com/read/28862085/value-based-healthcare-as-a-trigger-for-improvement-initiatives
#7
Kerstin Nilsson, Fredrik Bååthe, Annette Erichsen Andersson, Mette Sandoff
Purpose This study explores four pilot teams' experiences of improvements resulting from the implementation of value-based healthcare (VBHC) at a Swedish University Hospital. The aim of this study is to gain a deeper understanding of VBHC when used as a management strategy to improve patients' health outcomes. Design/methodology/approach An exploratory design was used and qualitative interviews were undertaken with 20 team members three times each, during a period of two years. The content of the interviews was qualitatively analysed...
September 1, 2017: Leadership in Health Services
https://www.readbyqxmd.com/read/28828664/extraction-and-analysis-of-extracellular-vesicle-associated-mirnas-following-antibody-based-extracellular-vesicle-capture-from-plasma-samples
#8
Davide Zocco, Natasa Zarovni
Extracellular vesicle (EV)-associated RNAs (EV-RNA) are under intense investigation due to their potential role in health and disease. Several approaches are currently employed to isolate blood-derived EVs for RNA analysis, most of which are either time-consuming and expensive, such as methods based on EVs physical properties (ultracentrifugation and Optiprep density gradient), or also copurify blood contaminants, mostly protein aggregates and immune complexes, (such as chemical precipitation). In addition, there is a lack of standardized protocols for the extraction of EV-RNA and very little consensus on the technological platforms and normalization tools for assessing the expression levels of different RNA species...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28812179/a-hybrid-co-culture-model-with-endothelial-cells-designed-for-the-hepatic-tissue-engineering
#9
Xiaoning Yang, Xin Wang, Xiaobo Huang, Ruiqiang Hang, Xiangyu Zhang, Bin Tang
The cultured hepatic cells in vitro are prone to losing their characteristic morphologies and biological functions. To avoid this problem, a hybrid co-culture system was proposed to elucidate the effect of cellular communication on the phenotype of hepatic cells. A monolayer of endothelial cells (ECs) was co-cultured on the surface of a three-dimensional (3D) scaffold embedded with HepG2 cells. In this hybrid co-culture system, the growth of encapsulated hepatic cells is barely influenced by the co-cultured ECs...
August 10, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28808461/the-effect-of-calcium-chloride-on-push-out-bond-strength-of-calcium-enriched-mixture-cement-and-mineral-trioxide-aggregate
#10
Mohammad Mehdi Shokouhi, Abbas Abbaszadegan, Amin Ameri, Seyed Masih Sharifian, Mohammadreza Nabavizadeh
INTRODUCTION: This in vitro study investigated the effect of adding 10% calcium chloride (CaCl2) on push out bond strength of calcium-enriched mixture (CEM) cement and mineral trioxide aggregate (MTA) to root canal dentin. METHODS AND MATERIALS: A total of 120 root dentin slices with 2 mm thickness were prepared from sixty single-rooted human teeth. Dentinal discs were enlarged to achieve 1.3 mm diameter. The specimens were randomly allocated into eight groups (n=15)...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28795872/selecting-an-acoustic-correlate-for-automated-measurement-of-american-english-rhotic-production-in-children
#11
Heather Campbell, Daphna Harel, Elaine Hitchcock, Tara McAllister Byun
PURPOSE: A current need in the field of speech-language pathology is the development of reliable and efficient techniques to evaluate accuracy of speech targets over the course of treatment. As acoustic measurement techniques improve, it should become possible to use automated scoring in lieu of ratings from a trained clinician in some contexts. This study asks which acoustic measures correspond most closely with expert ratings of children's productions of American English /ɹ/ in an effort to develop an automated scoring algorithm for use in treatment targeting rhotics...
August 10, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28795435/effect-of-carbon-supports-on-enhancing-mass-kinetic-current-density-of-fe-n-c-electrocatalysts
#12
Xinghua Chen, Fei He, Yanfei Shen, Yiran Yang, Hao Mei, Songqin Liu, Toshiyuki Mori, Yuanjian Zhang
The mass kinetic current density (mass JK ) of most extensively reported M-N/C catalysts (M represents non-precious metal elements such as Fe, Co, and Cu), a potential alternative to noble metal catalysts in fuel cells, is poorer than that of commercial Pt/C. Thus, deep understanding of the intrinsic roles of carbon supports may contribute to the development of M-N/C catalysts from a practical point of view. Herein, the routinely used carbon supports, i.e. carbon black (CB) and carbon nanotubes (CNT) that have different morphology and crystallinity, were investigated to uncover the factors that affected the mass JK of Fe-N/C in electrocatalytic oxygen reduction...
August 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28791034/a-high-throughput-standard-pcr-based-genotyping-method-for-determining-transgene-zygosity-in-segregating-plant-populations
#13
Lige Geng, Dewayne D Deng, Martin J Wubben, Johnie N Jenkins, Jack C McCarty, Ibrokhim Abdurakhmonov
In crop research programs that implement transgene-based strategies for trait improvement it is necessary to distinguish between transgene homozygous and hemizygous individuals in segregating populations. Direct methods for determining transgene zygosity are technically challenging, expensive, and require specialized equipment. In this report, we describe a standard PCR-based protocol coupled with capillary electrophoresis that can identify transgene homozygous and hemizygous individuals in a segregating population without knowledge of transgene insertion site...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28790967/rethinking-neuroprotection-in-severe-traumatic-brain-injury-toward-bedside-neuroprotection
#14
REVIEW
Tommaso Zoerle, Marco Carbonara, Elisa R Zanier, Fabrizio Ortolano, Giulio Bertani, Sandra Magnoni, Nino Stocchetti
Neuroprotection after traumatic brain injury (TBI) is an important goal pursued strenuously in the last 30 years. The acute cerebral injury triggers a cascade of biochemical events that may worsen the integrity, function, and connectivity of the brain cells and decrease the chance of functional recovery. A number of molecules acting against this deleterious cascade have been tested in the experimental setting, often with preliminary encouraging results. Unfortunately, clinical trials using those candidate neuroprotectants molecules have consistently produced disappointing results, highlighting the necessity of improving the research standards...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28782433/relational-schemas-as-mediators-of-innovative-moments-in-symptom-improvement-in-major-depression
#15
João Batista, Joana Silva, Sara Freitas, Daniela Alves, Anabela Machado, Inês Sousa, Pablo Fernández-Navarro, Carina Magalhães, Miguel M Gonçalves
OBJECTIVES: Innovative moments (IMs) are exceptions to the maladaptive framework of meaning that typically motivates clients to seek psychotherapy, and previous studies have shown that IMs are associated with psychotherapy outcomes. While IMs are exceptions that occur at the level of the therapeutic conversation, relational schemas are more stable patterns, and their increased flexibility may facilitate change during psychotherapy. With this in mind, we tested the hypothesis that IMs contribute to outcomes by improving the flexibility of relational schemas...
August 5, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28777707/understanding-barriers-to-healthy-behaviors-in-college-black-men
#16
Krista Mincey, Brian L Turner, Amber Brown, Sheldon Maurice
OBJECTIVE: Due to the short life expectancy of Black men, it is important to understand what impacts health behaviors in this group so that interventions and programs can be developed to improve their health behaviors which may help increase the life expectancy of Black men. The purpose of this study was to understand what perceived barriers exist for Black college men that prevent them from engaging in healthy behaviors. PARTICIPANTS AND METHODS: Thirty-five Black male students at a southern Historically Black College and University (HBCU) participated in five focus groups and four interviews...
August 4, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28743265/the-predictive-value-of-respiratory-function-tests-for-non-invasive-ventilation-in-amyotrophic-lateral-sclerosis
#17
T B M Tilanus, J T Groothuis, J M C TenBroek-Pastoor, T B Feuth, Y F Heijdra, J P L Slenders, J Doorduin, B G Van Engelen, M J Kampelmacher, J Raaphorst
BACKGROUND: Non-invasive ventilation (NIV) improves survival and quality of life in amyotrophic lateral sclerosis (ALS) patients. The timing of referral to a home ventilation service (HVS), which is in part based on respiratory function tests, has shown room for improvement. It is currently unknown which respiratory function test predicts an appropriate timing of the initiation of NIV. METHODS: We analysed, retrospectively, serial data of five respiratory function tests: forced vital capacity (FVC), peak cough flow (PCF), maximum inspiratory and expiratory pressure (MIP and MEP) and sniff nasal inspiratory pressure (SNIP) in patients with ALS...
July 25, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28738234/m1-homeopathic-complex-trigger-effective-responses-against-leishmania-l-amazonensis-in-vivo-and-in-vitro
#18
Katia Fialho Nascimento, Fabiana Rodrigues de Santana, Cleber Rafael Vieira da Costa, Vanessa Kaplum, Helito Volpato, Celso Vaturo Nakamura, Leoni Villano Bonamin, Dorly de Freitas Buchi
Leishmaniasis is a term referring to a range of clinical conditions caused by protozoan parasites of the genus Leishmania, Trypanosomatidae family, Kinetoplastida order that is transmitted by the bite of certain species of mosquitoes Phlebotominae subfamily. These parasites infect hosts wild and domestic mammals, considered as natural reservoirs and can also infect humans. Leishmania are obligate intramacrophage protozoa that have exclusively intracellular life style. This suggests that the amastigotes possess mechanisms to avoid killing by host cells...
July 21, 2017: Cytokine
https://www.readbyqxmd.com/read/28736309/neural-interactions-mediating-conflict-control-and-its-training-induced-plasticity
#19
Min Hu, Xiangpeng Wang, Wenwen Zhang, Xueping Hu, Antao Chen
Cognitive control is of great plasticity. Training programs targeted on improving it have been suggested to yield neural changes in the brain. However, until recently, the relationship between training-induced brain changes and improvements in cognitive control is still an open issue. Besides, although the literature has attributed the operation of cognitive control to interactions between large-scale networks, the neural pathways directly associated with it remain unclear. The current study aimed to examine these issues by focusing on conflict processing...
July 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28733533/similar-outcomes-after-haploidentical-transplantation-with-post-transplant-cyclophosphamide-versus-hla-matched-transplantation-a-meta-analysis-of-case-control-studies
#20
Zhenyang Gu, Li Wang, Lei Yuan, Wenrong Huang, Meng Li, Lixun Guan, Qingyi Wang, Zhe Gao, Shasha Zhao, Lan Luo, Feiyan Wang, Nan Yang, Daihong Liu, Jon C Aster, Chunji Gao
BACKGROUND: Outcomes of haploidentical hematopoietic cell transplantation (haplo-HCT) with post-transplant cyclophosphamide (PT-Cy) have greatly improved. It remains unknown whether haplo-HCT with PT-Cy was associated with poor outcomes when compared with HLA-matched HCT. To address this issue, we performed a meta-analysis to compare outcomes of haplo-HCT with PT-Cy with those of HLA-matched HCT. METHODS: A systematic search for case-control studies were performed in PubMed, Embase and Cochrane Library databases...
June 29, 2017: Oncotarget
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