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https://www.readbyqxmd.com/read/27920546/chronotherapy-with-low-dose-modified-release-prednisone-for-the-management-of-rheumatoid-arthritis-a-review
#1
REVIEW
Stefano Paolo Beltrametti, Aurora Ianniello, Clara Ricci
To date, rheumatoid arthritis (RA) remains a debilitating, life-threatening disease. One major concern is morning symptoms (MS), as they considerably impair the patients' quality of life and ability to work. MS change in a circadian fashion, resembling the fluctuations of inflammatory cytokines such as interleukin-6, whose levels are higher in RA patients compared to healthy donors. Conversely, serum levels of the potent anti-inflammatory glucocorticoid cortisol are similar to that of healthy subjects, suggesting an imbalance that sustains a pro-inflammatory state...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27918903/a-confirmatory-factor-analysis-of-the-utrecht-work-engagement-scale-for-students-in-a-chinese-sample
#2
Lina Meng, Yi Jin
BACKGROUND: Educational institutions play an important role in encouraging students' engagement with course work. Educators are finding instruments to measure students' engagement in order to develop strategies to improve it. Little is known about the factor structure of the Utrecht Work Engagement Scale for Students among Chinese nursing students. OBJECTIVES: The aim of this research was to examine the factor structure of the Utrecht Work Engagement Scale for Students via confirmatory factor analysis...
November 26, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27915345/long-term-follow-up-of-patients-with-spasmodic-dysphonia-and-improved-voice-despite-discontinuation-of-treatment
#3
Ahmed Geneid, Per-Åke Lindestad, Svante Granqvist, Riitta Möller, Maria Södersten
OBJECTIVE: To evaluate voice function in patients with adductor spasmodic dysphonia (AdSD) who discontinued botulinum toxin (BTX) treatment because they felt that their voice had improved sufficiently. PATIENTS AND METHODS: Twenty-eight patients quit treatment in 2004, of whom 20 fulfilled the inclusion criteria for the study, with 3 subsequently excluded because of return of symptoms, leaving 17 patients (11 males, 6 females) included in this follow-up study. A questionnaire concerning current voice function and the Voice Handicap Index were completed...
December 3, 2016: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/27914504/on-treatment-analysis-of-the-improved-reduction-of-outcomes-vytorin-efficacy-international-trial-improve-it
#4
Michael A Blazing, Robert P Giugliano, James A de Lemos, Christopher P Cannon, Andrew Tonkin, Christie M Ballantyne, Basil S Lewis, Thomas A Musliner, Andrew M Tershakovec, Yuliya Lokhnygina, Jennifer A White, Craig Reist, Amy McCagg, Eugene Braunwald
BACKGROUND: We aimed to determine the efficacy and safety of adding ezetimibe (Ez) to simvastatin (S) in a post-acute coronary syndrome (ACS) population in a prespecified on-treatment analysis. METHODS: We evaluated 17,706 post-ACS patients from the IMPROVE-IT trial who had low-density lipoprotein cholesterol values between 50 and 125 mg/dL and who received Ez 10 mg/d with S 40 mg/d (Ez/S) or placebo with simvastatin 40 mg/d (P/S). The primary composite end point was cardiovascular death, myocardial infarction, unstable angina, coronary revascularization ≥30 days postrandomization, or stroke...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27900534/heart-failure-management-in-the-elderly-a%C3%A2-public-health-challenge
#5
REVIEW
Natasa Cvetinovic, Goran Loncar, Jerneja Farkas
Heart failure (HF) is a rapidly growing public health problem and the leading cause of morbidity, mortality, and hospitalization in populations > 65 years. The elderly HF patients have an increased prevalence of HF with preserved ejection fraction and comorbidities, may present with atypical symptoms and signs, have a higher risk for adverse drug reactions, and worse prognosis as compared with younger patients. Moreover, there is a lack of evidence-based therapies for this population because they are underrepresented in the clinical trials...
November 29, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27894470/effectiveness-of-a-placebo-intervention-on-visually-induced-nausea-in-women-a-randomized-controlled-pilot-study
#6
Veronika Müller, Kirsten Remus, Verena Hoffmann, Matthias H Tschöp, Karin Meissner
OBJECTIVE: Improvement of nausea by placebo interventions has recently been demonstrated in clinical trials and experimental settings. However, many questions regarding placebo effects on nausea remain unanswered. For example, nausea reduction in women could only be achieved when the placebo intervention was "enhanced" by conditioning, while men responded primarily to verbally suggested improvement. It is unclear whether these findings are generalizable or were due to situational variables...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27889873/information-technology-based-interventions-to-improve-drug-drug-interaction-outcomes-a-systematic-review-on-features-and-effects
#7
Ehsan Nabovati, Hasan Vakili-Arki, Zhila Taherzadeh, Mohammad Reza Saberi, Stephanie Medlock, Ameen Abu-Hanna, Saeid Eslami
The purpose of this systematic review was to identify features and effects of information technology (IT)-based interventions on outcomes related to drug-drug interactions (DDI outcomes). A literature search was conducted in Medline, EMBASE, and the Cochrane Library for published English-language studies. Studies were included if a main outcome was related to DDIs, the intervention involved an IT-based system, and the study design was experimental or observational with controls. Study characteristics, including features and effects of IT-based interventions, were extracted...
January 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/27889859/chronic-high-dose-glucocorticoid-therapy-triggers-the-development-of-chronic-organ-damage-and-worsens-disease-outcome-in-systemic-lupus-erythematosus
#8
Tünde Tarr, Gábor Papp, Nikolett Nagy, Edina Cserép, Margit Zeher
Long-term survival of patients with systemic lupus erythematosus (SLE) improved worldwide; thus, prevention of cumulative organ damage became a major goal in disease management. The aim of our study was to investigate the chronic organ damages and their influence on disease outcome in SLE. We evaluated clinical conditions, laboratory findings and medications of 357 consecutive SLE patients and assessed their impact on Systemic Lupus Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) and disease outcome...
November 26, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27888494/patient-specific-computer-modelling-its-role-in-the-planning-of-transcatheter-aortic-valve-implantation
#9
REVIEW
N El Faquir, B Ren, N M Van Mieghem, J Bosmans, P P de Jaegere
Transcatheter aortic valve implantation is increasingly used to treat patients with severe aortic stenosis who are at increased risk for surgical aortic valve replacement and is projected to be the preferred treatment modality. As patient selection and operator experience have improved, it is hypothesised that device-host interactions will play a more dominant role in outcome. This, in combination with the increasing number of valve types and sizes, confronts the physician with the dilemma to choose the valve that best fits the individual patient...
November 25, 2016: Netherlands Heart Journal
https://www.readbyqxmd.com/read/27887644/copenhagen-comorbidity-in-hiv-infection-cocomo-study-a-study-protocol-for-a-longitudinal-non-interventional-assessment-of-non-aids-comorbidity-in-hiv-infection-in-denmark
#10
Andreas Ronit, Judith Haissman, Ditte Marie Kirkegaard-Klitbo, Thomas Skårup Kristensen, Anne-Mette Lebech, Thomas Benfield, Jan Gerstoft, Henrik Ullum, Lars Køber, Andreas Kjær, Klaus Kofoed, Jørgen Vestbo, Børge Nordestgaard, Jens Lundgren, Susanne Dam Nielsen
BACKGROUND: Modern combination antiretroviral therapy (cART) has improved survival for people living with HIV (PLWHIV). Non-AIDS comorbidities have replaced opportunistic infections as leading causes of mortality and morbidity, and are becoming a key health concern as this population continues to age. The aim of this study is to estimate the prevalence and incidence of non-AIDS comorbidity among PLWHIV in Denmark in the cART era and to determine risk factors contributing to the pathogenesis...
November 26, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27880825/can-simple-transmission-chains-foster-collective-intelligence-in-binary-choice-tasks
#11
Mehdi Moussaïd, Kyanoush Seyed Yahosseini
In many social systems, groups of individuals can find remarkably efficient solutions to complex cognitive problems, sometimes even outperforming a single expert. The success of the group, however, crucially depends on how the judgments of the group members are aggregated to produce the collective answer. A large variety of such aggregation methods have been described in the literature, such as averaging the independent judgments, relying on the majority or setting up a group discussion. In the present work, we introduce a novel approach for aggregating judgments-the transmission chain-which has not yet been consistently evaluated in the context of collective intelligence...
2016: PloS One
https://www.readbyqxmd.com/read/27869198/sub-optimality-in-motor-planning-is-retained-throughout-9-days-practice-of-2250-trials
#12
Keiji Ota, Masahiro Shinya, Kazutoshi Kudo
Optimality in motor planning, as well as accuracy in motor execution, is required to maximize expected gain under risk. In this study, we tested whether humans are able to update their motor planning. Participants performed a coincident timing task with an asymmetric gain function, in which optimal response timing to gain the highest total score depends on response variability. Their behaviours were then compared using a Bayesian optimal decision model. After 9 days of practicing 2250 trials, the total score increased, and temporal variance decreased...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27866412/failing-to-deliver-established-quality-treatment-for-cervical-cancer-what-is-going-on-and-how-can-we-improve-it
#13
Colin Hill, Daniel M Trifiletti, Timothy N Showalter
No abstract text is available yet for this article.
November 21, 2016: Future Oncology
https://www.readbyqxmd.com/read/27855582/clinical-research-nurse-interns-the-future-research-workforce
#14
Karen Roberts, Sophie Gelder, Helen Wild
To ensure that patient care is continuously improved, it is essential that research becomes an integral aspect of clinical care and the NHS Constitution for England ( Department of Health 2012 ) sets out the patients' right to be involved in research as a treatment option.
November 18, 2016: Nurse Researcher
https://www.readbyqxmd.com/read/27847867/multicolor-3d-meta-holography-by-broadband-plasmonic-modulation
#15
Xiong Li, Lianwei Chen, Yang Li, Xiaohu Zhang, Mingbo Pu, Zeyu Zhao, Xiaoliang Ma, Yanqin Wang, Minghui Hong, Xiangang Luo
As nanofabrication technology progresses, the emerging metasurface has offered unique opportunities for holography, such as an increased data capacity and the realization of polarization-sensitive functionality. Multicolor three-dimensional (3D) meta-hologram imaging is one of the most pursued applications for meta-hologram not yet realized. How to reduce the cross-talk among different colors in broad bandwidth designs is a critical question. On the basis of the off-axis illumination method, we develop a novel way to overcome the cross-talk limitation and achieve multicolor meta-holography with a single type of plasmonic pixel...
November 2016: Science Advances
https://www.readbyqxmd.com/read/27844097/the-effects-of-unilateral-versus-bilateral-subthalamic-nucleus-deep-brain-stimulation-on-prosaccades-and-antisaccades-in-parkinson-s-disease
#16
Lisa C Goelz, Fabian J David, John A Sweeney, David E Vaillancourt, Howard Poizner, Leonard Verhagen Metman, Daniel M Corcos
Unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease improves skeletomotor function assessed clinically, and bilateral STN DBS improves motor function to a significantly greater extent. It is unknown whether unilateral STN DBS improves oculomotor function and whether bilateral STN DBS improves it to a greater extent. Further, it has also been shown that bilateral, but not unilateral, STN DBS is associated with some impaired cognitive-motor functions. The current study compared the effect of unilateral and bilateral STN DBS on sensorimotor and cognitive aspects of oculomotor control...
November 14, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27843761/common-methods-of-measuring-informed-choice-in-screening-participation-challenges-and-future-directions
#17
REVIEW
Alex Ghanouni, Cristina Renzi, Susanne F Meisel, Jo Waller
There is general agreement among public health practitioners, academics, and policymakers that people offered health screening tests should be able to make informed choices about whether to accept. Robust measures are necessary in order to gauge the extent to which informed choice is achieved in practice and whether efforts to improve it have succeeded. This review aims to add to the literature on how to improve methods of measuring informed choice. We discuss and critique commonly-used approaches and outline possible alternative methods that might address the issues identified...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27834605/the-impact-of-accreditation-on-healthcare-quality-improvement-a-qualitative-case-study
#18
Sara Melo
Purpose Research on accreditation has mostly focused on assessing its impact using large scale quantitative studies, yet little is known on how quality is improved in practice through an accreditation process. Using a case study of an acute teaching hospital in Portugal, the purpose of this paper is to explore the dynamics through which accreditation can lead to an improvement in the quality of healthcare services provided. Design/methodology/approach Data for the case study was collected through 46 in-depth semi-structured interviews with 49 clinical and non-clinical members of staff...
November 21, 2016: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/27829939/the-knowledge-of-polish-primary-care-physicians-about-bariatric-surgery
#19
Piotr Major, Tomasz Stefura, Monika Jezierska-Kazberuk, Michał Wysocki, Michał Pędziwiatr, Magdalena Pisarska, Piotr Małczak, Artur Kacprzyk, Andrzej Budzyński
INTRODUCTION: The general practitioner (GP) can play a key role in this multi-disciplinary team, coordinating care provided by dietitians and surgeons, maximizing the potential benefits of surgery. Therefore, it seems important to verify changes in GPs' knowledge about surgical treatment of obesity. AIM: To reassess knowledge of obesity surgical treatment among Polish primary care physicians and their willingness to improve it in the future. MATERIAL AND METHODS: To assess the knowledge of Polish primary care physicians about surgical treatment of obesity, a prospective study, which included an anonymous online questionnaire, was conducted in the years 2015-2016...
2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/27828741/resilience-why-it-matters-and-how-doctors-can-improve-it
#20
Jonathan Mills, Judy McKimm
Resilience is the ability to cope with challenges and withstand pressure. It is subjective and affects individuals differently. Understanding how to build one's own resilience and being aware when others in the team are struggling is essential for any aspiring clinical leader.
November 2, 2016: British Journal of Hospital Medicine
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