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Lane F Donnelly, Shirley S Cherian, Kimberly B Chua, Sam Thankachan, Laura A Millecker, Alex G Koroll, George S Bisset
BACKGROUND: Because of the increasing complexities of providing imaging for pediatric health care services, a more reliable process to manage the daily delivery of care is necessary. Objective We describe our Daily Readiness Huddle and the effects of the process on problem identification and improvement. MATERIALS AND METHODS: Our Daily Readiness Huddle has four elements: metrics review, clinical volume review, daily readiness assessment, and problem accountability...
October 22, 2016: Pediatric Radiology
Shobhit Srivastava, Anil K Saksena, Sanjay Khattri, Santosh Kumar, Raghubendra Singh Dagur
BACKGROUND AND PURPOSE: Curcuma longa L. (CL), an Indian herb, has been used to treat many disorders because of its wide spectrum of pharmacological activities. It has been shown to exhibit anti-oxidant and anti-inflammatory properties, and is being used as herbal remedy since ancient times. Osteoarthritis of knee (KOA) is a chronic painful disorder in which prolong use of non-steroidal anti-inflammatory drugs (NSAIDs) or steroids may result into many serious side effects; hence, there is a need to develop herbal drugs, having good analgesia without side effects...
October 19, 2016: Inflammopharmacology
Xin Ma, Jing Liu, Zhengxiang Zhang, Tao Bo, Yu Bai, Huwei Liu
RATIONALE: Quadrupole based tandem mass spectrometry (MS/MS) plays critical role in "omics" studies. However, when a particular m/z precursor is selected by the quadrupole, ions other than the precursor are not transmitted through, the sensitivity and dynamic range thus diminish. Therefore, separation techniques such as ion mobility (IM) is coupled with MS/MS to improve it. METHODS: In this workflow, every IM-mass spectrometry (MS) scan was followed by one high collision energy (CE) scan...
October 19, 2016: Rapid Communications in Mass Spectrometry: RCM
Yunzhu Meng, Wansoo Pak, Berkan Guleyupoglu, Bharath Koya, F Scott Gayzik, Costin D Untaroiu
Child pedestrian protection deserves more attention in vehicle safety design since they are the most vulnerable road users who face the highest mortality rate. Pediatric Finite Element (FE) models could be used to simulate and understand the pedestrian injury mechanisms during crashes in order to mitigate them. Thus, the objective of the study was to develop a computationally efficient (simplified) six-year-old (6YO-PS) pedestrian FE model and validate it based on the latest published pediatric data. The 6YO-PS FE model was developed by morphing the existing GHBMC adult pedestrian model...
October 16, 2016: Accident; Analysis and Prevention
Sameer Bakhshi, Sainath Bhethanabhotla, Rakesh Kumar, Krishankant Agarwal, Punit Sharma, Sanjay Thulkar, Arun Malhotra, Deepa Dhawan, Sreenivas Vishnubhatla
BACKGROUND: Data about significance of (18)F-FDG positron emission tomography (PET) at interim assessment and end of treatment in pediatric Hodgkin lymphoma (HL) are limited. METHODS: Patients (≤18 years) with HL were prospectively evaluated with contrast-enhanced computed tomography (CECT) and PET combined with low-dose CT(PET-CT) at baseline, post 2 cycles of chemotherapy and post completion of treatment. Revised international working group criteria (RIW) and Deauville (DA) five point-scale for response assessment by PET-CT were used...
October 6, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Francielle A Mendes, Tânia de F Borges, Luiz C Gonçalves, Terezinha Rc de Oliveira, Célio J do Prado, Flávio D das Neves
The aim of this study is to evaluate the effects of replacing poorly fitting dentures on patient's masticatory function, satisfaction and oral health-related quality of life. Fourteen patients with conventional maxillary complete dentures and mandibular overdentures retained by two implants bar clip system had their dentures replaced. The laboratory tests for the analysis of masticatory performance were conducted using an "Optocal" food simulator test. Questionnaires were used to evaluate patient satisfaction with dentures and impact of oral health on quality of life...
September 2016: Acta Odontológica Latinoamericana: AOL
Brandon Michael Henry, Krzysztof A Tomaszewski, Piravin Kumar Ramakrishnan, Joyeeta Roy, Jens Vikse, Marios Loukas, R Shane Tubbs, Jerzy A Walocha
BACKGROUND: Critical appraisal of anatomical studies is essential before the evidence from them undergoes meta-epidemiological synthesis. However, no instrument for appraising anatomical studies with inherent applicability to different study designs is available. We aim to develop a generic yet comprehensive tool for assessing the quality of anatomical studies using a formal consensus method. MATERIALS AND METHODS: The study steering committee formulated an initial conceptual design and generated items for a preliminary tool on the basis of a literature review and expert opinion...
October 7, 2016: Clinical Anatomy
Sergei Grudinin, Maria Kadukova, Andreas Eisenbarth, Simon Marillet, Frédéric Cazals
The 2015 D3R Grand Challenge provided an opportunity to test our new model for the binding free energy of small molecules, as well as to assess our protocol to predict binding poses for protein-ligand complexes. Our pose predictions were ranked 3-9 for the HSP90 dataset, depending on the assessment metric. For the MAP4K dataset the ranks are very dispersed and equal to 2-35, depending on the assessment metric, which does not provide any insight into the accuracy of the method. The main success of our pose prediction protocol was the re-scoring stage using the recently developed Convex-PL potential...
October 7, 2016: Journal of Computer-aided Molecular Design
Jesse M Pines
In this issue of Academic Emergency Medicine, Patterson et al. report a link between two measures of emergency department (ED) crowding -ED census and physician load - to hospital admission decisions. Disposition appeared to change based on both the degree of ED crowding and how many total patients the physician making the admission decision was carrying at the time. This translated to important swings: an average admission rate of 35% with an empty waiting room and zero patient load which increased to 40% with 12 patients waiting or physician was carrying 16 ED patients...
October 5, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Melissa S D'Andrea, P Marco Fisichella
BACKGROUND: Postoperative pain remains undertreated in critically ill patients. We hypothesized that the adequacy of pain control in our Surgical Intensive Care Unit (SICU) was above the reported average of 71 % in the literature and that the introduction of the critical care pain observation tool (CPOT) could improve it. We used a Lean Six Sigma methodology to improve our processes and quantify our improvement. PATIENTS AND METHODS: We retrospectively review 713 consecutive veterans admitted to our SICU...
October 4, 2016: World Journal of Surgery
Konstantinos N Fountoulakis
The prevailing picture in both the scientific literature and mass media is that the increase in unemployment acts as a generic risk factor on the entire population and increases the rate of suicide, suggesting that the socioeconomic environment is the determining factor and measures to improve it are the most suitable in the struggle to reduce the number of suicides. As a result, 'horizontal' actions targeting the general population are proposed rather than 'vertical' actions that target specific vulnerable groups...
October 2016: British Journal of Psychiatry: the Journal of Mental Science
Aqeel Munahi Almutairi, Tahir Ansari, Waqas Sami, Salah Baz
OBJECTIVES: Epilepsy is very common in the Kingdom of Saudi Arabia, occurring in 6.54 out of every 1000 individuals. The current study was conducted to determine the level of public awareness of and attitudes toward epilepsy in the city of Majmaah, Saudi Arabia. SUBJECTS AND METHODS: This descriptive study was conducted in Majmaah, Saudi Arabia. The study population included respondents derived from preselected public places in the city. Stratified random sampling was used, and the sample size was made up of 706 individuals...
October 2016: Journal of Neurosciences in Rural Practice
Tata Chanturidze, Konrad Obermann
Governance in health is cited as one of the key factors in balancing the concerns of the government and public sector with the interests of civil society/private players, but often remains poorly described and operationalized. Richard Saltman and Antonio Duran look at two aspects in the search for new provider models in a context of health markets signalling liberalisation: (i) the role of the government to balance public and private interests and responsibilities in delivering care through modernised governance arrangements, and (ii) the finding that operational complexities may hinder well-designed provider governance models, unless governance reflects country-specific realities...
May 17, 2016: International Journal of Health Policy and Management
Thomas M Gooding, Mark A Feger, Joseph M Hart, Jay Hertel
CONTEXT:  The intrinsic foot muscles maintain the medial longitudinal arch and aid in force distribution and postural control during gait. Impaired intrinsic foot-muscle function has been linked to various foot conditions. Several rehabilitative exercises have been proposed to improve it; however, literature that identifies which individual muscles are activated during specific intrinsic foot-muscle exercises is lacking. OBJECTIVE:  To describe changes in activation of the intrinsic plantar foot muscles after 4 exercises as measured with T2 time magnetic resonance imaging (MRI)...
October 3, 2016: Journal of Athletic Training
Anniek Boeijinga, Hans Hoeken, José Sanders
BACKGROUND: The working environment, the nature of the work, and the characteristics of truck drivers as a social group typically pose great challenges for the truck drivers' health and health promotion activities aiming to improve it. OBJECTIVE: The purpose was to obtain a better understanding of (a) Dutch truck drivers' perceptions of health and lifestyle themes, and (b) the challenges they experience in their pursuit of a more healthy lifestyle, as a guiding framework for the development of health interventions targeting this occupational group...
October 17, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
Katia Reichhart, Mélissa Evesque, Marion M C Cavana, Pauline Muszynski, Marie-Madeleine Leclercq, Nicolas Winisdoerffer, Maxime Sonntag
OBJECTIVE: Following a specific exercise program is beneficial to cancer patients because it can impact on health status, quality of life, symptoms and recurrence of cancer. Identifying barriers to exercise implementation and follow-up exercise behaviour can help maintaining regular physical activity levels. By searching for these barriers, we investigate how to improve maintenance of physical activity after a local exercise-training program in order to highlight practical solutions to improve it...
September 2016: Annals of Physical and Rehabilitation Medicine
Adina M Piovesana, Stephanie Ross, Owen Lloyd, Koa Whittingham, Jenny Ziviani, Robert S Ware, Roslyn N Boyd
: Purpose state: Determine the efficacy of Move-it-to-improve-it (Mitii™), a multi-modal web-based program, in improving Executive Function (EF) in children with unilateral cerebral palsy (UCP). METHOD: Participants (n = 102) were matched in pairs then randomized to: intervention (Mitii™ for 20 weeks; n = 51; 26 males; mean age = 11 years 8 months (SD = 2 years 4 months); Full Scale IQ = 84.65 (SD = 15.19); 28 left UCP; GMFCS-E&R (I = 20, II = 31) or waitlist control (n = 50; 25 males; mean age = 11 years 10 months (SD = 2 years 5 months); Full Scale IQ = 80...
September 24, 2016: Disability and Rehabilitation
Alexandre Dal-Pan, Stéphanie Dudonné, Philippe Bourassa, Morgane Bourdoulous, Cyntia Tremblay, Yves Desjardins, Frédéric Calon
No effective preventive treatment is available for age-related cognitive decline and Alzheimer's disease (AD). Epidemiological studies indicate that a diet rich in fruit is associated with cognitive improvement. It was thus proposed that high polyphenol concentrations found in berries can prevent cognitive impairment associated with aging and AD. Therefore, the Neurophenols project aimed at investigating the effects of a polyphenolic extract from blueberries and grapes (PEBG) in the triple-transgenic (3xTg-AD) mouse model of AD, which develops AD neuropathological markers, including amyloid-β plaques and neurofibrillary tangles, leading to memory deficits...
September 20, 2016: Journal of Alzheimer's Disease: JAD
José-Ángel García-Pedraza, Pedro Ferreira-Santos, Rubén Aparicio, María-José Montero, Asunción Morán
This study aimed to determine whether the serotonergic modulation, through selective 5-HT2 receptor blockade, restores cardiovascular disturbances in type 1 diabetic rats. Diabetes was induced by alloxan (150 mg/kg, s.c.) and maintained for 4 weeks. 5-HT2 receptor was blocked by sarpogrelate (30 mg/; 14 days; p.o.). Systolic blood pressure (SBP), heart rate (HR), glycaemia and body weight (BW) were monitored periodically. Animals were sacrificed at the end of the study and the heart, right kidney and thoracic aorta were removed; plasma samples were also obtained...
2016: Scientific Reports
A Siltari, R Korpela, H Vapaatalo
Bradykinin exerts its vascular actions via two types of receptors, the non-constitutively expressed bradykinin receptor type 1 (BR1) and the constitutive type 2 receptor (BR2). Bradykinin-induced vasorelaxation is age-dependent, a phenomenon related to the varying amounts of BR1 and BR2 in the vasculature. Isoleucine-proline-proline (Ile-Pro-Pro), a bioactive tripeptide, lowers elevated blood pressure and improves impaired endothelium-dependent vasorelaxation in hypertensive rats. It inhibits angiotensin converting enzyme 1 (ACE1)...
September 11, 2016: Peptides
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