keyword
https://read.qxmd.com/read/38494092/deucrictibant-for-angioedema-due-to-acquired-c1-inhibitor-deficiency-a-randomized-controlled-trial
#21
JOURNAL ARTICLE
Remy S Petersen, Lauré M Fijen, Johannes P Kelder, Danny M Cohn
BACKGROUND: Angioedema due to acquired C1-inhibitor deficiency is a very rare but serious disease, with an estimated prevalence of 1 per 500,000 persons. There are no approved therapies to treat or prevent angioedema swellings in patients with this condition. Deucrictibant is a specific, orally bioavailable, competitive antagonist of the bradykinin B2 receptor currently under investigation for hereditary angioedema. OBJECTIVE: To assess the efficacy and safety of deucrictibant as acute and prophylactic treatment for angioedema due to acquired C1-inhibitor deficiency...
March 15, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38493772/comparison-of-caudal-block-and-sacral-erector-spina-block-for-postoperative-analgesia-following-pediatric-circumcision-a-double-blind-randomized-controlled-trial
#22
JOURNAL ARTICLE
Volkan Özen, Ayça Sultan Şahin, Elif Aybike Ayyildiz, Mehmet Eren Açık, Tayfun Eyileten, Nurten Özen
INTRODUCTION: Caudal block (CB) and erector spina plane block (ESPB) has been shown to provide effective postoperative analgesia following circumcision. Our aim was to compare the analgesic efficacy of sacral ESPB and CB, as well as the time to first analgesic requirement and postoperative complications. METHODS: Patients aged 1-7 years in the ASA I-II group, who were scheduled for circumcision were included in the study. Blocks were performed under general anesthesia before the operation...
March 16, 2024: Urologia Internationalis
https://read.qxmd.com/read/38493679/the-effect-of-a-single-dose-of-nivolumab-prior-to-isolated-limb-perfusion-for-patients-with-in-transit-melanoma-metastases-an-interim-analysis-of-a-phase-ib-ii-randomized-double-blind-placebo-controlled-trial-nivoilp-trial
#23
JOURNAL ARTICLE
Carl-Jacob Holmberg, Lisanne P Zijlker, Dimitrios Katsarelias, Anne E Huibers, Michel W J M Wouters, Yvonne Schrage, Sophie J M Reijers, Johannes V van Thienen, Dirk J Grünhagen, Anna Martner, Jonas A Nilsson, Alexander C J van Akkooi, Lars Ny, Winan J van Houdt, Roger Olofsson Bagge
OBJECTIVE: ILP has shown to achieve high response rates in patients with melanoma ITM. Possibly there is a synergistic mechanism of action of ILP and anti-PD1. The aim of this trial was to investigate the safety and efficacy of adding a single dose of systemic anti-PD1 to isolated limb perfusion (ILP) for patients with melanoma in-transit metastases (ITM). METHODS: In this placebo controlled double-blind phase Ib/II trial, patients with melanoma ITM were randomized 1:1 to either a single systemic dose of nivolumab or placebo one day prior to ILP...
March 12, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38493540/effect-of-corticosteroids-on-ischemia-reperfusion-injury-of-deep-inferior-epigastric-perforator-flap-after-re-exploration-for-anastomosis-thrombosis-a-prospective-randomized-trial
#24
JOURNAL ARTICLE
Simone La Padula, Pasquale M Bufalino, Romain Bosc, Michele Maruccia, Rossella Elia, Francesco D'Andrea, Jean P Meningaud, Barbara Hersant, Rosita Pensato
Patients undergoing breast reconstruction with the deep inferior epigastric perforator (DIEP) flap are at risk of arterial and venous thrombosis, necessitating flap salvage surgery. However, this carries the risk of ischemia-reperfusion injury (IRI) and potential significant partial or complete flap loss. The objective of this study was to evaluate the potential benefit of corticosteroids in reducing IRI related complications in DIEP flaps that are returned to the operation theater for attempted salvage after venous or arterial failure...
February 29, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38492903/upadacitinib-reduces-crohn-s-disease-symptoms-within-the-first-week-of-induction-therapy
#25
JOURNAL ARTICLE
Jean-Frédéric Colombel, Tadakazu Hisamatsu, Raja Atreya, Francesca Bresso, Lena Thin, Remo Panaccione, Rogério Serafim Parra, Sharanya Ford, Valencia P Remple, Ana Paula Lacerda, Samuel I Anyanwu, Madhuja Mallick, Andrew Garrison, Miguel Regueiro
BACKGROUND & AIMS: Upadacitinib (UPA), an oral Janus kinase inhibitor, is approved to treat moderately to severely active Crohn's disease (CD). As symptomatic response is an important initial treatment goal for patients, we evaluated the rapidity of symptomatic improvement in patients with CD receiving UPA 45 mg once daily (UPA45) induction therapy. METHODS: This post hoc analysis included pooled data from 2 phase 3, multicenter, double-blind 12-week induction trials (U-EXCEL and U-EXCEED) and 1 maintenance trial (U-ENDURE)...
March 14, 2024: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/38492684/the-effect-of-niacinamide-supplementation-on-phosphate-concentrations-in-dutch-dialysis-patients-a-randomised-crossover-trial
#26
JOURNAL ARTICLE
Lara Schepers, Inez Jans, Gerda K Pot, Arend-Jan Smilde, Julia M Hofstra, Nicole M de Roos
OBJECTIVE: Hyperphosphatemia is a common complication in patients with kidney failure, despite the use of phosphate binders (PBs). Vitamin B3, either in the form of niacin or niacinamide (NAM), shows potential as "add-on" treatment to reduce serum phosphate concentrations in this population. NAM seems to lack many of the side-effects that are observed with niacin. The aim of this study was to investigate whether NAM is an effective and acceptable treatment in reducing serum phosphate concentrations in patients with kidney failure...
March 14, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38492626/prospective-randomized-double-blind-study-to-evaluate-the-superiority-of-vasopressin-versus-norepinephrine-in-the-management-of-the-patient-at-renal-risk-undergoing-cardiac-surgery-with-cardiopulmonary-bypass-novacc-trial
#27
JOURNAL ARTICLE
Pierre-Grégoire Guinot, Olivier Desebbe, Guillaume Besch, Philippe Guerci, Philippe Gaudard, Diane Lena, Paul Michel Mertes, Osama Abou-Arab, Belaid Bouhemad
BACKGROUND: Cardiac surgery-associated acute kidney injury (CS-AKI) affects up to 30% of patients, increasing morbidity and healthcare costs. This condition results from complex factors like ischemia-reperfusion injury and renal hemodynamic changes, often exacerbated by surgical procedures. Norepinephrine, commonly used in cardiac surgeries, may heighten the risk of CS-AKI. In contrast, vasopressin, a non-catecholaminergic agent, shows potential in preserving renal function by favorably affecting renal hemodynamic...
March 14, 2024: American Heart Journal
https://read.qxmd.com/read/38492129/lack-of-effects-of-eight-week-left-dorsolateral-prefrontal-theta-burst-stimulation-on-white-matter-macro-microstructure-and-connection-in-autism
#28
JOURNAL ARTICLE
Chun-Hung Yeh, Po-Chun Lin, Rung-Yu Tseng, Yi-Ping Chao, Chen-Te Wu, Tai-Li Chou, Rou-Shayn Chen, Susan Shur-Fen Gau, Hsing-Chang Ni, Hsiang-Yuan Lin
Whether brain stimulation could modulate brain structure in autism remains unknown. This study explored the impact of continuous theta burst stimulation (cTBS) over the left dorsolateral prefrontal cortex (DLPFC) on white matter macro/microstructure in intellectually able children and emerging adults with autism. Sixty autistic participants were randomized (30 active) and received active or sham cTBS for eight weeks twice per week, 16 total sessions using a double-blind (participant-, rater-, analyst-blinded) design...
March 16, 2024: Brain Imaging and Behavior
https://read.qxmd.com/read/38491966/teduglutide-improves-liver-chemistries-in-short-bowel-syndrome-associated-intestinal-failure-post-hoc-analysis
#29
JOURNAL ARTICLE
Dejan Micic, Ian Robinson, Tanya Kidd, Brian Terreri, Bram P Raphael
BACKGROUND: Chronic hepatic complications are common in patients with short bowel syndrome-associated intestinal failure (SBS-IF). Teduglutide, a glucagon-like peptide-2 analogue, demonstrated efficacy in reducing parenteral nutrition and/or intravenous fluid dependence among patients with SBS-IF in phase 3 clinical studies. METHODS: This was a post hoc analysis of pooled data from two separate randomized, double-blind, placebo-controlled, multinational phase 3 clinical studies...
March 16, 2024: Nutrition in Clinical Practice
https://read.qxmd.com/read/38491528/onchocerca-volvulus-microfilariae-in-the-anterior-chambers-of-the-eye-and-ocular-adverse-events-after-a-single-dose-of-8%C3%A2-mg-moxidectin-or-150%C3%A2-%C3%A2%C2%B5g-kg-ivermectin-results-of-a-randomized-double-blind-phase-3-trial-in-the-democratic-republic-of-the-congo-ghana
#30
JOURNAL ARTICLE
Eric M Kanza, Amos Nyathirombo, Jemmah P Larbelee, Nicholas O Opoku, Didier K Bakajika, Hayford M Howard, Germain L Mambandu, Maurice M Nigo, Deogratias Ucima Wonyarossi, Françoise Ngave, Kambale Kasonia Kennedy, Kambale Kataliko, Kpehe M Bolay, Simon K Attah, George Olipoh, Sampson Asare, Mupenzi Mumbere, Michel Vaillant, Christine M Halleux, Annette C Kuesel
BACKGROUND: After ivermectin became available, diethylcarbamazine (DEC) use was discontinued because of severe adverse reactions, including ocular reactions, in individuals with high Onchocerca volvulus microfilaridermia (microfilariae/mg skin, SmfD). Assuming long-term ivermectin use led to < 5 SmfD with little or no eye involvement, DEC + ivermectin + albendazole treatment a few months after ivermectin was proposed. In 2018, the US FDA approved moxidectin for treatment of O...
March 15, 2024: Parasites & Vectors
https://read.qxmd.com/read/38491070/long-term-safety-and-efficacy-of-open-label-nabilone-on-sleep-and-pain-in-parkinson%C3%A2-s-disease
#31
JOURNAL ARTICLE
Marina Peball, Beatrice Heim, Federico Carbone, Oliver Schorr, Mario Werkmann, Philipp Ellmerer, Kathrin Marini, Florian Krismer, Hans-Günther Knaus, Werner Poewe, Atbin Djamshidian, Klaus Seppi
The synthetic tetrahydrocannabinol-analog nabilone improved non-motor symptoms (NMS) in Parkinson's disease (PD) patients in a placebo-controlled, double-blind, parallel-group, randomized withdrawal trial with enriched enrollment (NMS-Nab-study). This was a single-center open-label extension study to assess the long-term safety and efficacy of nabilone for NMS in PD. To be eligible for this study, patients had to be treatment responders during the previous NMS-Nab-trial and complete its double-blind phase without experiencing a drug-related serious/severe/moderate adverse event (AE)...
March 15, 2024: NPJ Parkinson's Disease
https://read.qxmd.com/read/38490696/concordance-and-agreement-between-different-activity-scores-in-polymyalgia-rheumatica
#32
JOURNAL ARTICLE
Justine D'Agostino, Aghiles Souki, Anne Lohse, Guillermo Carvajal Alegria, Emanuelle Dernis, Christophe Richez, Marie-Elise Truchetet, Daniel Wendling, Eric Toussirot, Aleth Perdriger, Jacques-Eric Gottenberg, Renaud Felten, Bruno Fautrel, Laurent Chiche, Pascal Hilliquin, Catherine Le Henaff, Benjamin Dervieux, Guillaume Direz, Isabelle Chary-Valckenaere, Divi Cornec, Dewi Guellec, Thierry Marhadour, Emmanuel Nowak, Alain Saraux, Valérie Devauchelle-Pensec
OBJECTIVE: The C reactive protein polymyalgia rheumatica activity score (CRP-PMR-AS) is a composite index that includes CRP levels and was developed specifically for PMR. As treatments such as interleukin-6 antagonists can normalise CRP levels, the erythrocyte sedimentation rate (ESR) of PMR-AS, the clinical (clin)-PMR-AS and the imputed-CRP (imp-CRP)-PMR-AS have been developed to avoid such bias. Our primary objective was to measure the correlation of these activity scores. Our secondary objective was to evaluate the concordance between different cutoffs of the PMR-ASs...
March 15, 2024: RMD Open
https://read.qxmd.com/read/38490687/neurophysiological-outcomes-that-sustained-clinically-significant-improvements-over-3-years-of-physiologic-ecap-controlled-closed-loop-spinal-cord-stimulation-for-the-treatment-of-chronic-pain
#33
JOURNAL ARTICLE
Nagy A Mekhail, Robert M Levy, Timothy R Deer, Leonardo Kapural, Sean Li, Kasra Amirdelfan, Corey W Hunter, Steven M Rosen, Shrif J Costandi, Steven M Falowski, Abram H Burgher, Jason E Pope, Christopher A Gilmore, Farooq A Qureshi, Peter S Staats, James Scowcroft, Tory McJunkin, Christopher K Kim, Michael I Yang, Thomas Stauss, Richard Rauck, Rui V Duarte, Nicole Soliday, Angela Leitner, Erin Hanson, Zhonghua Ouyang, Dave Mugan, Lawrence Poree
INTRODUCTION: A novel, spinal cord stimulation (SCS) system with a physiologic closed-loop (CL) feedback mechanism controlled by evoked compound action potentials (ECAPs) enables the optimization of physiologic neural dose and the accuracy of the stimulation, not possible with any other commercially available SCS systems. The report of objective spinal cord measurements is essential to increase the transparency and reproducibility of SCS therapy. Here, we report a cohort of the EVOKE double-blind randomized controlled trial treated with CL-SCS for 36 months to evaluate the ECAP dose and accuracy that sustained the durability of clinical improvements...
March 15, 2024: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/38490660/multicentre-randomised-double-blind-placebo-controlled-proof-of-concept-study-of-lsalt-peptide-as-prevention-of-acute-respiratory-distress-syndrome-and-acute-kidney-injury-in-patients-infected-with-sars-cov-2-covid-19
#34
JOURNAL ARTICLE
Ranjani Somayaji, David R Luke, Arthur Lau, Rahmet Guner, Ŏ Fehmi Tabak, Mark Hepokoski, Nancy Gardetto, Steven A Conrad, Sunil D Kumar, Kalyan Ghosh, Stephen M Robbins, Donna L Senger, Daisy Sun, Rachel K S Lim, Jonathan Liu, Fatma Eser, Ridvan Karaali, Alain Tremblay, Daniel Muruve
OBJECTIVE: Dipeptidase-1 (DPEP-1) is a recently discovered leucocyte adhesion receptor for neutrophils and monocytes in the lungs and kidneys and serves as a potential therapeutic target to attenuate inflammation in moderate-to-severe COVID-19. We aimed to evaluate the safety and efficacy of the DPEP-1 inhibitor, LSALT peptide, to prevent specific organ dysfunction in patients hospitalised with COVID-19. DESIGN: Phase 2a randomised, placebo-controlled, double-blinded, trial...
March 15, 2024: BMJ Open
https://read.qxmd.com/read/38490359/antimicrobial-prophylaxis-in-companion-animal-surgery-a-scoping-review-for-european-network-for-optimization-of-antimicrobial-therapy-enovat-guidelines
#35
JOURNAL ARTICLE
T M Sørensen, K Scahill, J Espinel Ruperez, M Olejnik, F Swinbourne, D R Verwilghen, M C Nolff, S Baines, C Marques, A Vilen, E L Duarte, M Dias, S Dewulf, A Wichtowska, A Carranza Valencia, L Pelligand, E M Broens, P L Toutain, M Alishani, M L Brennan, J S Weese, L R Jessen, F Allerton
Surgical antimicrobial prophylaxis (SAP) is widely used to reduce the risk of surgical site infections (SSI), but there is uncertainty as to what the proportion of SSI reduction is. Therefore, it is difficult for surgeons to properly weigh the costs, risks and benefits for individual patients when deciding on the use of SAP, making it challenging to promote antimicrobial stewardship in primary practice settings. The objective of this study was to map the veterinary evidence focused on assessing the effect of SAPon SSI development and in order to identify surgical procedures with some research evidence and possible knowledge gaps...
March 13, 2024: Veterinary Journal
https://read.qxmd.com/read/38490102/implantation-of-a-double-allogeneic-human-engineered-tissue-graft-on-damaged-heart-insights-from-the-periscope-phase-i-clinical-trial
#36
JOURNAL ARTICLE
Antoni Bayes-Genis, Paloma Gastelurrutia, Marta Monguió-Tortajada, Maria Luisa Cámara, Cristina Prat-Vidal, German Cediel, Luciano Rodríguez-Gómez, Albert Teis, Elena Revuelta-López, Gemma Ferrer-Curriu, Santiago Roura, Carolina Gálvez-Montón, Felipe Bisbal, Joaquim Vives, Anna Vilarrodona, Christian Muñoz-Guijosa, Sergi Querol
BACKGROUND: In preclinical studies, the use of double allogeneic grafts has shown promising results in promoting tissue revascularization, reducing infarct size, preventing adverse remodelling and fibrosis, and ultimately enhancing cardiac function. Building upon these findings, the safety of PeriCord, an engineered tissue graft consisting of a decellularised pericardial matrix and umbilical cord Wharton's jelly mesenchymal stromal cells, was evaluated in the PERISCOPE Phase I clinical trial (NCT03798353), marking its first application in human subjects...
March 14, 2024: EBioMedicine
https://read.qxmd.com/read/38490083/a-randomised-placebo-controlled-double-blind-crossover-trial-on-the-effect-of-a-20-1-cannabidiol-%C3%AE-9-tetrahydrocannabinol-medical-cannabis-product-on-neurocognition-attention-and-mood
#37
JOURNAL ARTICLE
Brooke Manning, Amie C Hayley, Sarah Catchlove, Con Stough, Luke A Downey
As cannabinoid-based medications gain popularity in the treatment of refractory medical conditions, it is crucial to examine the neurocognitive effects of commonly prescribed products to ensure associated safety profiles. The present study aims to investigate the acute effects of a standard 1 mL sublingual dose of CannEpil®, a medicinal cannabis oil containing 100 mg cannabidiol (CBD) and 5 mg Δ9-tetrahydrocannabinol (THC) on neurocognition, attention, and mood. A randomised, double-blind, placebo-controlled, within-subjects design assessed 31 healthy participants (16 female, 15 male), aged between 21 and 58 years, over a two-week experimental protocol...
March 14, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/38490043/a-randomized-double-blind-clinical-trial-comparison-of-oclacitinib-with-a-traditional-chinese-herbal-medicine-product-dihuang-guiqin-capsule-in-the-treatment-of-canine-atopic-dermatitis
#38
JOURNAL ARTICLE
Jun-Jie Qin, Hao Zhu, Zhe-Wen Song, Xiao-Jiao Hou, Xiu-Min Wang, Lei Wang, Jian-Xi Li
Canine atopic dermatitis (cAD) is a common chronic inflammatory skin disease, which seriously affects the quality of life for both dogs and their owners. Currently, the common therapeutic drugs in the clinic have disadvantages such as obvious adverse effects and high prices. Traditional Chinese herbal medicine (TCHM) has great potential for the treatment of cAD. The aim of this study is to compare the effects of different doses of the TCHM product (Dihuang Guiqin capsule) and oclacitinib in the treatment of cAD through a randomized, double-blind trial...
March 11, 2024: Research in Veterinary Science
https://read.qxmd.com/read/38489966/comparisons-in-analgesic-effects-between-ultrasound-guided-erector-spinae-plane-block-and-surgical-intercostal-nerve-block-after-video-assisted-thoracoscopic-surgery-a-randomized-controlled-trial
#39
JOURNAL ARTICLE
Chun-Sung Sung, Tzu-Jung Wei, Jung-Jyh Hung, Fu-Wei Su, Shih-I Ho, Mong-Wei Lin, Kuang-Cheng Chan, Chun-Yu Wu
STUDY OBJECTIVE: This study aimed to compare the analgesic effects of anesthesiologist-administrated erector spinae plane block (ESPB) and surgeon-administrated intercostal nerve block (ICNB) following video-assisted thoracoscopic surgery (VATS). DESIGN: Randomized, controlled, double-blinded study. SETTING: Operating room, postoperative recovery room and ward in two centers. PATIENTS: One hundred patients, ASA I-III and scheduled for elective VATS...
March 14, 2024: Journal of Clinical Anesthesia
https://read.qxmd.com/read/38489844/framework-nucleic-acids-combined-with-three-dimensional-hybridization-chain-reaction-amplifiers-for-monitoring-multiple-human-tear-cytokines
#40
JOURNAL ARTICLE
Xing Lu, Xujiao Zhou, Bin Song, Hong Zhang, Mingrui Cheng, Xingyu Zhu, Yuqi Wu, Haoliang Shi, Binbin Chu, Jiaxu Hong, Houyu Wang, Yao He
Existing tear sensors are difficult to perform multiplexed assays due to the minute amounts of biomolecules in tearsand the tiny volume of tears. Herein, we leverage DNA tetrahedral frameworks (DTFs) modified on the wireless portable electrodes to effectively capture three dimensional (3D)-hybridization chain reaction (HCR) amplifiers for automatic and sensitive monitoring of multiple cytokines in human tears. The developed sensors allow the sensitive determination of various dry eye syndrome (DES)-associated cytokines in human tears with the limit of detection down to 0...
March 15, 2024: Advanced Materials
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